E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.007 0.071 -9999.0 0.0 -0.291 22.0 22.0 KLHL20 0.048 0.09 0.202 61.0 -0.182 20.0 81.0 CYFIP2 0.031 0.013 -9999.0 0.0 0.0 78.0 78.0 Rac1/GDP 0.007 0.061 0.194 2.0 -0.256 14.0 16.0 ENAH 0.007 0.074 -9999.0 0.0 -0.311 21.0 21.0 AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.0 0.0 0.0 60.0 -0.0 12.0 72.0 RAP1A 0.036 0.005 -9999.0 0.0 0.0 11.0 11.0 CTNNB1 0.036 0.006 -9999.0 0.0 0.0 15.0 15.0 CDC42/GTP -0.026 0.052 0.119 13.0 -0.194 24.0 37.0 ABI1/Sra1/Nap1 -0.014 0.033 -9999.0 0.0 -0.131 31.0 31.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.084 0.036 -9999.0 0.0 -0.128 8.0 8.0 RAPGEF1 -0.006 0.074 0.184 1.0 -0.278 21.0 22.0 CTNND1 0.034 0.009 -9999.0 0.0 0.0 32.0 32.0 regulation of calcium-dependent cell-cell adhesion 0.02 0.076 -9999.0 0.0 -0.291 23.0 23.0 CRK -0.0 0.076 0.195 1.0 -0.29 22.0 23.0 E-cadherin/gamma catenin/alpha catenin 0.061 0.035 -9999.0 0.0 -0.123 8.0 8.0 alphaE/beta7 Integrin 0.049 0.025 -9999.0 0.0 -0.141 7.0 7.0 IQGAP1 0.033 0.011 -9999.0 0.0 0.0 51.0 51.0 NCKAP1 0.036 0.002 -9999.0 0.0 0.0 2.0 2.0 Rap1/GTP/I-afadin 0.043 0.015 -9999.0 0.0 -0.101 1.0 1.0 DLG1 0.007 0.075 -9999.0 0.0 -0.295 23.0 23.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.035 0.044 -9999.0 0.0 -0.177 30.0 30.0 MLLT4 0.034 0.009 -9999.0 0.0 0.0 36.0 36.0 ARF6/GTP/NME1/Tiam1 0.036 0.033 -9999.0 0.0 -0.1 23.0 23.0 PI3K -0.043 0.058 0.059 2.0 -0.227 30.0 32.0 ARF6 0.035 0.008 -9999.0 0.0 0.0 27.0 27.0 mol:Ca2+ 0.0 0.0 0.001 69.0 -0.0 27.0 96.0 E-cadherin/gamma catenin 0.048 0.018 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.033 0.011 -9999.0 0.0 0.0 46.0 46.0 E-cadherin(dimer)/Ca2+ 0.07 0.054 -9999.0 0.0 -0.137 25.0 25.0 AKT1 -0.023 0.052 0.132 7.0 -0.175 25.0 32.0 PIK3R1 0.032 0.012 -9999.0 0.0 0.0 63.0 63.0 CDH1 0.034 0.01 -9999.0 0.0 0.0 38.0 38.0 RhoA/GDP 0.011 0.07 0.19 3.0 -0.237 18.0 21.0 actin cytoskeleton organization 0.04 0.072 0.168 62.0 -0.138 17.0 79.0 CDC42/GDP 0.011 0.068 0.19 3.0 -0.241 15.0 18.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.049 -9999.0 0.0 -0.195 23.0 23.0 ITGB7 0.036 0.005 -9999.0 0.0 0.0 11.0 11.0 RAC1 0.024 0.017 -9999.0 0.0 0.0 173.0 173.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.077 0.057 -9999.0 0.0 -0.147 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.056 0.031 -9999.0 0.0 -0.11 10.0 10.0 mol:GDP -0.006 0.071 0.184 3.0 -0.271 16.0 19.0 CDC42/GTP/IQGAP1 0.035 0.042 -9999.0 0.0 -0.115 33.0 33.0 JUP 0.033 0.011 -9999.0 0.0 0.0 51.0 51.0 p120 catenin/RhoA/GDP 0.026 0.077 0.203 3.0 -0.242 19.0 22.0 RAC1/GTP/IQGAP1 0.023 0.042 -9999.0 0.0 -0.116 30.0 30.0 PIP5K1C/AP1M1 0.02 0.03 -9999.0 0.0 -0.131 18.0 18.0 RHOA 0.035 0.007 -9999.0 0.0 0.0 18.0 18.0 CDC42 0.035 0.008 -9999.0 0.0 0.0 24.0 24.0 CTNNA1 0.035 0.007 -9999.0 0.0 0.0 20.0 20.0 positive regulation of S phase of mitotic cell cycle 0.014 0.045 0.112 8.0 -0.124 28.0 36.0 NME1 -0.0 0.0 -9999.0 0.0 -0.0 31.0 31.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.008 0.072 -9999.0 0.0 -0.302 20.0 20.0 regulation of cell-cell adhesion -0.028 0.04 -9999.0 0.0 -0.168 26.0 26.0 WASF2 -0.008 0.018 -9999.0 0.0 -0.071 31.0 31.0 Rap1/GTP -0.023 0.061 0.149 19.0 -0.22 22.0 41.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.09 0.051 -9999.0 0.0 -0.128 13.0 13.0 CCND1 0.016 0.054 0.128 8.0 -0.151 28.0 36.0 VAV2 0.019 0.101 -9999.0 0.0 -0.521 9.0 9.0 RAP1/GDP -0.011 0.064 0.161 17.0 -0.245 16.0 33.0 adherens junction assembly 0.009 0.071 -9999.0 0.0 -0.293 20.0 20.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.017 -9999.0 0.0 0.0 152.0 152.0 PIP5K1C 0.033 0.011 -9999.0 0.0 0.0 50.0 50.0 regulation of heterotypic cell-cell adhesion 0.068 0.047 0.201 3.0 -0.134 14.0 17.0 E-cadherin/beta catenin 0.006 0.02 -9999.0 0.0 -0.092 7.0 7.0 mol:GTP 0.0 0.0 0.001 63.0 -0.0 31.0 94.0 SRC 0.006 0.073 -9999.0 0.0 -0.289 23.0 23.0 PIK3CA 0.031 0.013 -9999.0 0.0 0.0 80.0 80.0 Rac1/GTP -0.007 0.07 0.184 1.0 -0.283 21.0 22.0 E-cadherin/beta catenin/alpha catenin 0.064 0.036 -9999.0 0.0 -0.132 10.0 10.0 ITGAE 0.035 0.007 -9999.0 0.0 0.0 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.02 0.077 -9999.0 0.0 -0.296 23.0 23.0