Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.054 0.018 -9999.0 0.0 -9999.0 0.0 0.0 KIRREL 0.038 0.01 -9999.0 0.0 -0.041 1.0 1.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.054 0.018 -9999.0 0.0 -9999.0 0.0 0.0 PLCG1 0.035 0.007 -9999.0 0.0 0.0 19.0 19.0 ARRB2 0.035 0.008 -9999.0 0.0 0.0 26.0 26.0 WASL 0.024 0.017 -9999.0 0.0 0.0 172.0 172.0 Nephrin/NEPH1/podocin/CD2AP 0.084 0.05 0.2 1.0 -0.122 17.0 18.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.015 0.036 -9999.0 0.0 -0.226 5.0 5.0 FYN -0.008 0.046 0.181 24.0 -9999.0 0.0 24.0 mol:Ca2+ 0.086 0.037 0.193 1.0 -0.125 3.0 4.0 mol:DAG 0.087 0.037 0.197 1.0 -0.125 3.0 4.0 NPHS2 0.039 0.008 -9999.0 0.0 -0.041 1.0 1.0 mol:IP3 0.087 0.037 0.197 1.0 -0.125 3.0 4.0 regulation of endocytosis 0.052 0.05 -9999.0 0.0 -0.133 4.0 4.0 Nephrin/NEPH1/podocin/Cholesterol 0.07 0.028 0.155 8.0 -9999.0 0.0 8.0 establishment of cell polarity 0.054 0.018 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2 0.096 0.058 -9999.0 0.0 -0.136 16.0 16.0 Nephrin/NEPH1/beta Arrestin2 0.055 0.051 -9999.0 0.0 -0.134 4.0 4.0 NPHS1 0.039 0.01 0.077 7.0 -9999.0 0.0 7.0 Nephrin/NEPH1/podocin 0.053 0.044 0.209 1.0 -0.104 1.0 2.0 TJP1 0.034 0.01 -9999.0 0.0 0.0 38.0 38.0 NCK1 0.035 0.008 -9999.0 0.0 0.0 27.0 27.0 NCK2 0.035 0.007 -9999.0 0.0 0.0 17.0 17.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.089 0.038 0.2 1.0 -0.125 3.0 4.0 CD2AP 0.034 0.01 -9999.0 0.0 0.0 41.0 41.0 Nephrin/NEPH1/podocin/GRB2 0.087 0.043 0.2 1.0 -0.125 7.0 8.0 GRB2 0.035 0.007 -9999.0 0.0 0.0 17.0 17.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.014 0.049 0.178 25.0 -9999.0 0.0 25.0 cytoskeleton organization -0.009 0.036 0.168 9.0 -0.216 3.0 12.0 Nephrin/NEPH1 0.046 0.016 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/ZO-1 0.064 0.038 -9999.0 0.0 -0.138 9.0 9.0