Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.034 0.032 -9999.0 0.0 -9999.0 0.0 0.0 IHH 0.051 0.012 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 0.014 0.027 -9999.0 0.0 -0.11 15.0 15.0 LRPAP1 0.035 0.007 -9999.0 0.0 0.0 18.0 18.0 dorsoventral neural tube patterning -0.014 0.026 0.109 15.0 -9999.0 0.0 15.0 SMO/beta Arrestin2 0.09 0.065 0.262 14.0 -9999.0 0.0 14.0 SMO 0.025 0.031 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.009 0.128 -9999.0 0.0 -0.485 23.0 23.0 ARRB2 0.035 0.008 -9999.0 0.0 0.0 26.0 26.0 BOC -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.036 0.006 -9999.0 0.0 0.0 13.0 13.0 heart looping 0.026 0.033 0.234 2.0 -9999.0 0.0 2.0 STIL 0.053 0.094 0.187 154.0 -9999.0 0.0 154.0 DHH N/PTCH2 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.016 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.031 0.013 -9999.0 0.0 0.0 80.0 80.0 DHH 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.038 0.048 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry 0.026 0.033 0.234 2.0 -9999.0 0.0 2.0 PIK3R1 0.032 0.012 -9999.0 0.0 0.0 63.0 63.0 skeletal system development 0.038 0.047 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.026 0.033 0.234 2.0 -9999.0 0.0 2.0 pancreas development 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.035 0.007 -9999.0 0.0 0.0 20.0 20.0 PI3K 0.019 0.075 -9999.0 0.0 -0.155 73.0 73.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.03 0.014 -9999.0 0.0 0.0 87.0 87.0 somite specification 0.026 0.033 0.234 2.0 -9999.0 0.0 2.0 SHH Np/Cholesterol/PTCH1 0.017 0.023 0.165 1.0 -9999.0 0.0 1.0 SHH Np/Cholesterol/PTCH2 0.02 0.016 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin 0.02 0.016 -9999.0 0.0 -9999.0 0.0 0.0 SHH -0.014 0.012 0.092 1.0 -9999.0 0.0 1.0 catabolic process 0.02 0.025 0.138 22.0 -9999.0 0.0 22.0 SMO/Vitamin D3 0.023 0.04 0.189 19.0 -9999.0 0.0 19.0 SHH Np/Cholesterol/Hhip -0.01 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LRP2 0.036 0.006 -9999.0 0.0 0.0 13.0 13.0 receptor-mediated endocytosis 0.022 0.038 0.268 2.0 -9999.0 0.0 2.0 SHH Np/Cholesterol/BOC -0.01 0.008 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/CDO 0.02 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation 0.01 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:Vitamin D3 0.079 0.089 0.197 173.0 -9999.0 0.0 173.0 IHH N/PTCH2 0.061 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.036 0.005 -9999.0 0.0 0.0 8.0 8.0 IHH N/PTCH1 0.046 0.028 -9999.0 0.0 -9999.0 0.0 0.0 Megalin/LRPAP1 0.048 0.029 -9999.0 0.0 -0.141 10.0 10.0 PTCH2 0.036 0.005 -9999.0 0.0 0.0 8.0 8.0 SHH Np/Cholesterol 0.011 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.02 0.025 0.138 22.0 -9999.0 0.0 22.0 HHIP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0