Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.01 0.057 -9999.0 0.0 -0.205 28.0 28.0 epithelial cell differentiation 0.063 0.051 -9999.0 0.0 -0.135 25.0 25.0 CYFIP2 0.031 0.013 -9999.0 0.0 0.0 78.0 78.0 ENAH -0.041 0.07 0.253 11.0 -0.256 8.0 19.0 EGFR 0.009 0.016 -9999.0 0.0 0.0 381.0 381.0 EPHA2 0.033 0.011 -9999.0 0.0 0.0 54.0 54.0 MYO6 -0.029 0.049 0.184 9.0 -0.212 13.0 22.0 CTNNB1 0.036 0.006 -9999.0 0.0 0.0 15.0 15.0 ABI1/Sra1/Nap1 0.031 0.063 -9999.0 0.0 -0.118 58.0 58.0 AQP5 -0.02 0.051 0.206 2.0 -0.283 9.0 11.0 CTNND1 0.034 0.009 -9999.0 0.0 0.0 32.0 32.0 mol:PI-4-5-P2 -0.031 0.044 0.176 6.0 -0.203 13.0 19.0 regulation of calcium-dependent cell-cell adhesion -0.028 0.044 0.184 8.0 -0.189 8.0 16.0 EGF 0.035 0.008 -9999.0 0.0 0.0 25.0 25.0 NCKAP1 0.036 0.002 -9999.0 0.0 0.0 2.0 2.0 AQP3 -0.035 0.075 -9999.0 0.0 -0.295 32.0 32.0 cortical microtubule organization 0.063 0.051 -9999.0 0.0 -0.135 25.0 25.0 GO:0000145 -0.03 0.04 0.159 6.0 -0.194 13.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.07 0.054 -9999.0 0.0 -0.136 25.0 25.0 MLLT4 0.034 0.009 -9999.0 0.0 0.0 36.0 36.0 ARF6/GDP -0.052 0.039 -9999.0 0.0 -0.156 34.0 34.0 ARF6 0.035 0.008 -9999.0 0.0 0.0 27.0 27.0 Ephrin A1/EPHA2/NCK1/GIT1 0.076 0.052 -9999.0 0.0 -0.124 24.0 24.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.029 0.079 0.159 1.0 -0.275 36.0 37.0 PVRL2 0.034 0.009 -9999.0 0.0 0.0 35.0 35.0 ZYX -0.021 0.046 0.178 6.0 -0.213 15.0 21.0 ARF6/GTP 0.079 0.059 -9999.0 0.0 -0.124 23.0 23.0 CDH1 0.034 0.01 -9999.0 0.0 0.0 38.0 38.0 EGFR/EGFR/EGF/EGF -0.001 0.059 -9999.0 0.0 -0.126 66.0 66.0 RhoA/GDP 0.063 0.056 -9999.0 0.0 -0.139 29.0 29.0 actin cytoskeleton organization -0.024 0.045 0.169 6.0 -0.223 12.0 18.0 IGF-1R heterotetramer 0.032 0.012 -9999.0 0.0 0.0 57.0 57.0 GIT1 0.036 0.003 -9999.0 0.0 0.0 4.0 4.0 IGF1R 0.033 0.012 -9999.0 0.0 0.0 57.0 57.0 IGF1 0.035 0.008 -9999.0 0.0 0.0 23.0 23.0 DIAPH1 -0.125 0.274 -9999.0 0.0 -0.572 59.0 59.0 Wnt receptor signaling pathway -0.063 0.051 0.135 25.0 -9999.0 0.0 25.0 RHOA 0.035 0.007 -9999.0 0.0 0.0 18.0 18.0 RhoA/GTP -0.053 0.041 -9999.0 0.0 -0.158 38.0 38.0 CTNNA1 0.035 0.007 -9999.0 0.0 0.0 20.0 20.0 VCL -0.024 0.046 0.17 6.0 -0.227 12.0 18.0 EFNA1 0.033 0.011 -9999.0 0.0 0.0 50.0 50.0 LPP -0.03 0.045 0.184 4.0 -0.222 13.0 17.0 Ephrin A1/EPHA2 0.046 0.062 -9999.0 0.0 -0.138 40.0 40.0 SEC6/SEC8 -0.044 0.028 -9999.0 0.0 -0.143 25.0 25.0 MGAT3 -0.028 0.044 0.186 8.0 -0.191 8.0 16.0 HGF/MET 0.036 0.05 -9999.0 0.0 -0.143 16.0 16.0 HGF 0.024 0.017 -9999.0 0.0 0.0 177.0 177.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.01 0.057 -9999.0 0.0 -0.206 28.0 28.0 actin cable formation -0.039 0.103 0.325 9.0 -0.299 32.0 41.0 KIAA1543 -0.025 0.036 0.159 7.0 -0.178 8.0 15.0 KIFC3 -0.031 0.042 0.193 5.0 -0.193 8.0 13.0 NCK1 0.035 0.008 -9999.0 0.0 0.0 27.0 27.0 EXOC3 0.036 0.003 -9999.0 0.0 0.0 4.0 4.0 ACTN1 -0.026 0.049 0.188 7.0 -0.209 16.0 23.0 NCK1/GIT1 0.05 0.022 -9999.0 0.0 -0.141 5.0 5.0 mol:GDP 0.063 0.051 -9999.0 0.0 -0.135 25.0 25.0 EXOC4 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.028 0.03 0.053 22.0 -0.129 25.0 47.0 PIP5K1C -0.031 0.045 0.178 6.0 -0.206 13.0 19.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.017 -9999.0 0.0 0.0 152.0 152.0 ROCK1 -0.034 0.085 0.345 11.0 -0.289 5.0 16.0 adherens junction assembly -0.023 0.073 0.232 6.0 -0.33 14.0 20.0 IGF-1R heterotetramer/IGF1 0.048 0.062 -9999.0 0.0 -0.143 37.0 37.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.047 0.023 -9999.0 0.0 -0.141 3.0 3.0 MET 0.023 0.018 -9999.0 0.0 0.0 191.0 191.0 PLEKHA7 -0.028 0.03 0.053 22.0 -0.129 25.0 47.0 mol:GTP 0.073 0.051 -9999.0 0.0 -0.123 24.0 24.0 establishment of epithelial cell apical/basal polarity -0.038 0.039 0.122 13.0 -0.182 10.0 23.0 cortical actin cytoskeleton stabilization 0.01 0.057 -9999.0 0.0 -0.205 28.0 28.0 regulation of cell-cell adhesion -0.024 0.045 0.169 6.0 -0.223 12.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.01 0.057 -9999.0 0.0 -0.206 28.0 28.0