Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.014 0.123 0.248 13.0 -9999.0 0.0 13.0 KIRREL 0.009 0.093 -9999.0 0.0 -0.498 2.0 2.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.014 0.123 -9999.0 0.0 -0.248 13.0 13.0 PLCG1 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.032 0.043 -9999.0 0.0 -0.307 1.0 1.0 Nephrin/NEPH1/podocin/CD2AP 0.018 0.126 -9999.0 0.0 -0.267 5.0 5.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.003 0.095 -9999.0 0.0 -0.343 3.0 3.0 FYN -0.028 0.137 0.278 4.0 -0.249 13.0 17.0 mol:Ca2+ 0.028 0.12 -9999.0 0.0 -0.269 5.0 5.0 mol:DAG 0.029 0.121 -9999.0 0.0 -0.27 5.0 5.0 NPHS2 -0.004 0.105 -9999.0 0.0 -0.331 6.0 6.0 mol:IP3 0.029 0.121 -9999.0 0.0 -0.27 5.0 5.0 regulation of endocytosis -0.006 0.122 -9999.0 0.0 -0.259 7.0 7.0 Nephrin/NEPH1/podocin/Cholesterol -0.003 0.118 -9999.0 0.0 -0.243 8.0 8.0 establishment of cell polarity -0.014 0.123 -9999.0 0.0 -0.248 13.0 13.0 Nephrin/NEPH1/podocin/NCK1-2 0.036 0.136 -9999.0 0.0 -0.293 5.0 5.0 Nephrin/NEPH1/beta Arrestin2 -0.005 0.124 -9999.0 0.0 -0.261 7.0 7.0 NPHS1 -0.026 0.137 -9999.0 0.0 -0.327 11.0 11.0 Nephrin/NEPH1/podocin -0.017 0.133 -9999.0 0.0 -0.249 13.0 13.0 TJP1 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.031 0.064 -9999.0 0.0 -0.487 1.0 1.0 NCK2 0.04 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.03 0.122 -9999.0 0.0 -0.271 5.0 5.0 CD2AP 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.021 0.127 -9999.0 0.0 -0.269 6.0 6.0 GRB2 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.033 0.142 0.29 4.0 -0.302 8.0 12.0 cytoskeleton organization -0.007 0.104 0.232 1.0 -0.359 3.0 4.0 Nephrin/NEPH1 0.002 0.087 -9999.0 0.0 -0.216 5.0 5.0 Nephrin/NEPH1/ZO-1 0.018 0.109 -9999.0 0.0 -0.286 3.0 3.0