Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.14 0.195 -9999.0 0.0 -0.496 12.0 12.0 IHH -0.084 0.141 -9999.0 0.0 -0.308 17.0 17.0 SHH Np/Cholesterol/GAS1 0.025 0.049 -9999.0 0.0 -9999.0 0.0 0.0 LRPAP1 0.04 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.024 0.048 -9999.0 0.0 -9999.0 0.0 0.0 SMO/beta Arrestin2 -0.067 0.158 -9999.0 0.0 -0.412 6.0 6.0 SMO -0.083 0.154 -9999.0 0.0 -0.372 11.0 11.0 AKT1 -0.056 0.204 -9999.0 0.0 -0.666 6.0 6.0 ARRB2 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.023 0.089 -9999.0 0.0 -0.487 2.0 2.0 ADRBK1 0.04 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.082 0.152 -9999.0 0.0 -0.367 11.0 11.0 STIL -0.046 0.116 -9999.0 0.0 -0.355 1.0 1.0 DHH N/PTCH2 0.043 0.07 -9999.0 0.0 -0.35 2.0 2.0 DHH N/PTCH1 -0.082 0.123 -9999.0 0.0 -0.278 13.0 13.0 PIK3CA 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.025 0.089 -9999.0 0.0 -0.487 2.0 2.0 PTHLH -0.231 0.358 -9999.0 0.0 -0.951 12.0 12.0 determination of left/right symmetry -0.082 0.152 -9999.0 0.0 -0.367 11.0 11.0 PIK3R1 0.002 0.129 -9999.0 0.0 -0.451 5.0 5.0 skeletal system development -0.229 0.353 -9999.0 0.0 -0.937 12.0 12.0 IHH N/Hhip -0.063 0.141 -9999.0 0.0 -0.294 14.0 14.0 DHH N/Hhip 0.002 0.139 -9999.0 0.0 -0.288 11.0 11.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.082 0.152 -9999.0 0.0 -0.367 11.0 11.0 pancreas development -0.021 0.141 -9999.0 0.0 -0.339 11.0 11.0 HHAT 0.032 0.043 -9999.0 0.0 -0.307 1.0 1.0 PI3K 0.028 0.1 -9999.0 0.0 -0.321 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.025 0.071 -9999.0 0.0 -0.307 3.0 3.0 somite specification -0.082 0.152 -9999.0 0.0 -0.367 11.0 11.0 SHH Np/Cholesterol/PTCH1 -0.066 0.1 -9999.0 0.0 -0.256 9.0 9.0 SHH Np/Cholesterol/PTCH2 0.033 0.029 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin -0.011 0.112 -9999.0 0.0 -0.284 9.0 9.0 SHH 0.019 0.029 -9999.0 0.0 -0.208 1.0 1.0 catabolic process -0.099 0.122 -9999.0 0.0 -0.286 16.0 16.0 SMO/Vitamin D3 -0.07 0.134 -9999.0 0.0 -0.311 11.0 11.0 SHH Np/Cholesterol/Hhip 0.003 0.081 -9999.0 0.0 -0.268 2.0 2.0 LRP2 -0.053 0.199 -9999.0 0.0 -0.487 12.0 12.0 receptor-mediated endocytosis -0.092 0.175 -9999.0 0.0 -0.409 12.0 12.0 SHH Np/Cholesterol/BOC 0.025 0.058 -9999.0 0.0 -0.268 2.0 2.0 SHH Np/Cholesterol/CDO 0.01 0.088 -9999.0 0.0 -0.303 4.0 4.0 mesenchymal cell differentiation -0.003 0.08 0.266 2.0 -9999.0 0.0 2.0 mol:Vitamin D3 -0.05 0.122 -9999.0 0.0 -0.257 9.0 9.0 IHH N/PTCH2 -0.02 0.092 -9999.0 0.0 -0.196 5.0 5.0 CDON -0.018 0.163 -9999.0 0.0 -0.465 8.0 8.0 IHH N/PTCH1 -0.092 0.131 -9999.0 0.0 -0.287 16.0 16.0 Megalin/LRPAP1 -0.011 0.15 -9999.0 0.0 -0.35 11.0 11.0 PTCH2 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.02 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.099 0.122 -9999.0 0.0 -0.286 16.0 16.0 HHIP -0.021 0.142 -9999.0 0.0 -0.34 11.0 11.0