Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.016 0.088 -9999.0 0.0 -0.245 8.0 8.0 epithelial cell differentiation 0.002 0.106 -9999.0 0.0 -0.247 8.0 8.0 CYFIP2 0.025 0.064 -9999.0 0.0 -0.487 1.0 1.0 ENAH 0.008 0.147 0.3 3.0 -0.33 5.0 8.0 EGFR -0.026 0.157 -9999.0 0.0 -0.397 10.0 10.0 EPHA2 0.018 0.097 -9999.0 0.0 -0.427 3.0 3.0 MYO6 0.028 0.131 0.223 1.0 -0.263 8.0 9.0 CTNNB1 0.027 0.019 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.05 0.062 -9999.0 0.0 -0.296 1.0 1.0 AQP5 0.015 0.111 -9999.0 0.0 -0.26 2.0 2.0 CTNND1 0.01 0.123 -9999.0 0.0 -0.487 4.0 4.0 mol:PI-4-5-P2 0.029 0.123 0.222 1.0 -0.236 7.0 8.0 regulation of calcium-dependent cell-cell adhesion -0.032 0.172 -9999.0 0.0 -0.31 14.0 14.0 EGF -0.13 0.206 -9999.0 0.0 -0.363 29.0 29.0 NCKAP1 0.029 0.059 -9999.0 0.0 -0.307 2.0 2.0 AQP3 -0.026 0.182 -9999.0 0.0 -0.519 6.0 6.0 cortical microtubule organization 0.002 0.106 -9999.0 0.0 -0.247 8.0 8.0 GO:0000145 0.017 0.116 0.192 9.0 -0.225 7.0 16.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.006 0.11 -9999.0 0.0 -0.249 8.0 8.0 MLLT4 0.03 0.064 -9999.0 0.0 -0.487 1.0 1.0 ARF6/GDP -0.056 0.13 -9999.0 0.0 -0.436 5.0 5.0 ARF6 0.036 0.014 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.032 0.152 -9999.0 0.0 -0.376 7.0 7.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.009 0.119 0.206 6.0 -0.306 2.0 8.0 PVRL2 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.021 0.117 -9999.0 0.0 -0.239 6.0 6.0 ARF6/GTP 0.038 0.147 -9999.0 0.0 -0.347 7.0 7.0 CDH1 -0.024 0.157 -9999.0 0.0 -0.397 10.0 10.0 EGFR/EGFR/EGF/EGF -0.094 0.145 -9999.0 0.0 -0.301 15.0 15.0 RhoA/GDP 0.006 0.103 -9999.0 0.0 -0.237 7.0 7.0 actin cytoskeleton organization 0.021 0.123 0.209 1.0 -0.27 6.0 7.0 IGF-1R heterotetramer 0.033 0.063 -9999.0 0.0 -0.486 1.0 1.0 GIT1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.033 0.063 -9999.0 0.0 -0.487 1.0 1.0 IGF1 -0.024 0.148 -9999.0 0.0 -0.356 11.0 11.0 DIAPH1 0.019 0.172 -9999.0 0.0 -0.642 3.0 3.0 Wnt receptor signaling pathway -0.002 0.106 0.247 8.0 -9999.0 0.0 8.0 RHOA 0.027 0.019 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.057 0.13 -9999.0 0.0 -0.434 5.0 5.0 CTNNA1 0.033 0.016 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.021 0.125 0.211 1.0 -0.276 6.0 7.0 EFNA1 -0.025 0.168 -9999.0 0.0 -0.487 8.0 8.0 LPP -0.007 0.137 0.2 6.0 -0.269 10.0 16.0 Ephrin A1/EPHA2 -0.037 0.148 -9999.0 0.0 -0.325 11.0 11.0 SEC6/SEC8 -0.02 0.084 -9999.0 0.0 -0.415 1.0 1.0 MGAT3 -0.033 0.174 -9999.0 0.0 -0.315 14.0 14.0 HGF/MET -0.013 0.102 -9999.0 0.0 -0.248 2.0 2.0 HGF 0.015 0.094 -9999.0 0.0 -0.352 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.016 0.089 -9999.0 0.0 -0.247 8.0 8.0 actin cable formation 0.049 0.167 0.272 14.0 -0.355 3.0 17.0 KIAA1543 0.016 0.12 -9999.0 0.0 -0.234 1.0 1.0 KIFC3 0.024 0.122 0.223 1.0 -0.237 8.0 9.0 NCK1 0.031 0.064 -9999.0 0.0 -0.487 1.0 1.0 EXOC3 0.033 0.063 -9999.0 0.0 -0.487 1.0 1.0 ACTN1 0.0 0.144 -9999.0 0.0 -0.285 9.0 9.0 NCK1/GIT1 0.048 0.059 -9999.0 0.0 -0.413 1.0 1.0 mol:GDP 0.002 0.106 -9999.0 0.0 -0.247 8.0 8.0 EXOC4 0.037 0.012 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.032 0.079 -9999.0 0.0 -0.237 8.0 8.0 PIP5K1C 0.029 0.124 0.223 1.0 -0.239 7.0 8.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.023 0.171 0.318 4.0 -0.379 5.0 9.0 adherens junction assembly 0.04 0.128 0.324 2.0 -9999.0 0.0 2.0 IGF-1R heterotetramer/IGF1 -0.023 0.13 -9999.0 0.0 -0.302 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.049 0.051 -9999.0 0.0 -0.35 1.0 1.0 MET 0.024 0.075 -9999.0 0.0 -0.397 2.0 2.0 PLEKHA7 0.026 0.122 -9999.0 0.0 -0.237 8.0 8.0 mol:GTP 0.03 0.15 -9999.0 0.0 -0.373 7.0 7.0 establishment of epithelial cell apical/basal polarity -0.026 0.08 -9999.0 0.0 -0.4 1.0 1.0 cortical actin cytoskeleton stabilization -0.016 0.088 -9999.0 0.0 -0.245 8.0 8.0 regulation of cell-cell adhesion 0.021 0.123 0.209 1.0 -0.27 6.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.016 0.089 -9999.0 0.0 -0.247 8.0 8.0