Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.029 0.078 -9999.0 0.0 -0.186 3.0 3.0 epithelial cell differentiation -0.012 0.092 -9999.0 0.0 -0.176 3.0 3.0 CYFIP2 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.053 0.079 -9999.0 0.0 -0.234 1.0 1.0 EGFR -0.04 0.127 -9999.0 0.0 -0.295 3.0 3.0 EPHA2 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.04 0.083 0.172 1.0 -9999.0 0.0 1.0 CTNNB1 -0.044 0.147 -9999.0 0.0 -0.35 3.0 3.0 ABI1/Sra1/Nap1 0.037 0.041 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.059 0.115 -9999.0 0.0 -0.396 1.0 1.0 CTNND1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.041 0.081 0.171 1.0 -9999.0 0.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.041 0.081 0.171 1.0 -9999.0 0.0 1.0 EGF -0.06 0.136 -9999.0 0.0 -0.251 5.0 5.0 NCKAP1 0.013 0.051 -9999.0 0.0 -0.185 1.0 1.0 AQP3 -0.054 0.116 -9999.0 0.0 -0.401 1.0 1.0 cortical microtubule organization -0.012 0.092 -9999.0 0.0 -0.176 3.0 3.0 GO:0000145 -0.039 0.077 0.158 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.009 0.095 -9999.0 0.0 -0.177 3.0 3.0 MLLT4 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.062 0.076 -9999.0 0.0 -0.296 1.0 1.0 ARF6 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.044 0.064 -9999.0 0.0 -0.189 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.029 0.08 0.166 1.0 -9999.0 0.0 1.0 PVRL2 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.037 0.084 0.172 1.0 -9999.0 0.0 1.0 ARF6/GTP 0.05 0.064 -9999.0 0.0 -0.178 1.0 1.0 CDH1 -0.025 0.109 -9999.0 0.0 -0.24 3.0 3.0 EGFR/EGFR/EGF/EGF -0.094 0.126 -9999.0 0.0 -0.313 3.0 3.0 RhoA/GDP -0.019 0.105 -9999.0 0.0 -0.188 4.0 4.0 actin cytoskeleton organization -0.041 0.08 0.16 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.013 0.051 -9999.0 0.0 -0.185 1.0 1.0 DIAPH1 0.015 0.131 -9999.0 0.0 -0.489 1.0 1.0 Wnt receptor signaling pathway 0.012 0.092 0.176 3.0 -9999.0 0.0 3.0 RHOA 0.003 0.091 -9999.0 0.0 -0.35 1.0 1.0 RhoA/GTP -0.072 0.086 -9999.0 0.0 -0.262 2.0 2.0 CTNNA1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.042 0.082 0.161 1.0 -9999.0 0.0 1.0 EFNA1 0.001 0.091 -9999.0 0.0 -0.35 1.0 1.0 LPP -0.041 0.078 0.163 1.0 -9999.0 0.0 1.0 Ephrin A1/EPHA2 -0.022 0.108 -9999.0 0.0 -0.317 1.0 1.0 SEC6/SEC8 -0.05 0.062 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.041 0.082 0.172 1.0 -9999.0 0.0 1.0 HGF/MET -0.016 0.071 -9999.0 0.0 -9999.0 0.0 0.0 HGF 0.02 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.029 0.078 -9999.0 0.0 -0.187 3.0 3.0 actin cable formation -0.008 0.111 0.255 1.0 -9999.0 0.0 1.0 KIAA1543 -0.055 0.09 0.163 1.0 -9999.0 0.0 1.0 KIFC3 -0.061 0.069 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.04 0.081 0.172 1.0 -9999.0 0.0 1.0 NCK1/GIT1 0.037 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.012 0.092 -9999.0 0.0 -0.176 3.0 3.0 EXOC4 0.02 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.049 0.062 -9999.0 0.0 -0.168 3.0 3.0 PIP5K1C -0.041 0.082 0.172 1.0 -9999.0 0.0 1.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.048 0.105 -9999.0 0.0 -0.268 1.0 1.0 adherens junction assembly -0.069 0.145 0.261 1.0 -0.462 1.0 2.0 IGF-1R heterotetramer/IGF1 -0.017 0.096 -9999.0 0.0 -0.191 3.0 3.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.018 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.035 0.082 0.172 1.0 -9999.0 0.0 1.0 mol:GTP 0.042 0.063 -9999.0 0.0 -0.189 1.0 1.0 establishment of epithelial cell apical/basal polarity -0.014 0.102 0.137 4.0 -9999.0 0.0 4.0 cortical actin cytoskeleton stabilization -0.029 0.078 -9999.0 0.0 -0.186 3.0 3.0 regulation of cell-cell adhesion -0.041 0.08 0.16 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.029 0.078 -9999.0 0.0 -0.187 3.0 3.0