Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.069 0.129 -9999.0 0.0 -0.23 9.0 9.0 epithelial cell differentiation -0.042 0.134 -9999.0 0.0 -0.209 9.0 9.0 CYFIP2 0.033 0.035 -9999.0 0.0 -0.144 1.0 1.0 ENAH -0.057 0.066 -9999.0 0.0 -0.272 1.0 1.0 EGFR -0.002 0.11 -9999.0 0.0 -0.295 3.0 3.0 EPHA2 0.03 0.018 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.069 0.13 0.185 1.0 -0.22 9.0 10.0 CTNNB1 0.008 0.107 -9999.0 0.0 -0.37 2.0 2.0 ABI1/Sra1/Nap1 0.063 0.04 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.052 0.101 -9999.0 0.0 -0.343 1.0 1.0 CTNND1 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.051 0.101 0.184 1.0 -0.181 9.0 10.0 regulation of calcium-dependent cell-cell adhesion -0.062 0.109 -9999.0 0.0 -0.197 9.0 9.0 EGF 0.025 0.048 -9999.0 0.0 -0.144 2.0 2.0 NCKAP1 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.05 0.101 -9999.0 0.0 -0.343 1.0 1.0 cortical microtubule organization -0.042 0.134 -9999.0 0.0 -0.209 9.0 9.0 GO:0000145 -0.062 0.087 0.166 1.0 -0.218 1.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.019 0.143 -9999.0 0.0 -0.211 9.0 9.0 MLLT4 0.022 0.078 -9999.0 0.0 -0.37 1.0 1.0 ARF6/GDP -0.08 0.084 -9999.0 0.0 -0.283 2.0 2.0 ARF6 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.074 0.049 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.074 0.11 -9999.0 0.0 -0.302 3.0 3.0 PVRL2 0.01 0.077 -9999.0 0.0 -0.37 1.0 1.0 ZYX -0.049 0.113 -9999.0 0.0 -0.205 8.0 8.0 ARF6/GTP 0.078 0.055 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.122 0.176 -9999.0 0.0 -0.273 14.0 14.0 EGFR/EGFR/EGF/EGF -0.06 0.128 -9999.0 0.0 -0.204 11.0 11.0 RhoA/GDP -0.017 0.135 -9999.0 0.0 -0.2 9.0 9.0 actin cytoskeleton organization -0.072 0.125 0.17 1.0 -0.219 9.0 10.0 IGF-1R heterotetramer 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.04 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.025 0.078 -9999.0 0.0 -0.37 1.0 1.0 DIAPH1 0.055 0.108 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.042 0.134 0.209 9.0 -9999.0 0.0 9.0 RHOA 0.037 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.08 0.085 -9999.0 0.0 -0.283 2.0 2.0 CTNNA1 0.04 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.074 0.128 0.172 1.0 -0.223 9.0 10.0 EFNA1 0.033 0.035 -9999.0 0.0 -0.144 1.0 1.0 LPP -0.066 0.089 0.174 1.0 -0.223 1.0 2.0 Ephrin A1/EPHA2 -0.032 0.128 -9999.0 0.0 -0.218 6.0 6.0 SEC6/SEC8 -0.062 0.117 -9999.0 0.0 -0.301 3.0 3.0 MGAT3 -0.063 0.11 -9999.0 0.0 -0.2 9.0 9.0 HGF/MET -0.049 0.125 -9999.0 0.0 -0.204 9.0 9.0 HGF 0.015 0.058 -9999.0 0.0 -0.144 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.07 0.13 -9999.0 0.0 -0.232 9.0 9.0 actin cable formation -0.045 0.064 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.081 0.097 -9999.0 0.0 -0.294 2.0 2.0 KIFC3 -0.063 0.113 0.185 1.0 -0.202 9.0 10.0 NCK1 0.04 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.04 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.063 0.113 0.185 1.0 -0.202 9.0 10.0 NCK1/GIT1 0.06 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.042 0.134 -9999.0 0.0 -0.209 9.0 9.0 EXOC4 0.034 0.014 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.082 0.091 -9999.0 0.0 -0.2 9.0 9.0 PIP5K1C -0.052 0.103 0.185 1.0 -0.184 9.0 10.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.036 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.072 0.078 -9999.0 0.0 -0.315 1.0 1.0 adherens junction assembly -0.037 0.128 0.298 1.0 -0.37 1.0 2.0 IGF-1R heterotetramer/IGF1 -0.021 0.142 -9999.0 0.0 -0.214 8.0 8.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.012 0.082 -9999.0 0.0 -0.26 2.0 2.0 MET 0.029 0.036 -9999.0 0.0 -0.144 1.0 1.0 PLEKHA7 -0.067 0.104 -9999.0 0.0 -0.202 9.0 9.0 mol:GTP 0.071 0.047 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.052 0.129 0.256 1.0 -0.29 3.0 4.0 cortical actin cytoskeleton stabilization -0.069 0.129 -9999.0 0.0 -0.23 9.0 9.0 regulation of cell-cell adhesion -0.072 0.125 0.17 1.0 -0.219 9.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.07 0.13 -9999.0 0.0 -0.232 9.0 9.0