Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	6.0	315.0	51.0	-0.907	0.04	1000.0	-1000.0	-0.11	-1000.0
E-cadherin signaling events	6.0	34.0	5.0	-0.122	0.04	1000.0	-1000.0	0.019	-1000.0
Ephrin A  reverse signaling	5.0	37.0	7.0	-0.095	0.01	1000.0	-1000.0	-0.0	-1000.0
TCGA08_retinoblastoma	5.0	40.0	8.0	-0.051	0.095	1000.0	-1000.0	-0.004	-1000.0
Syndecan-1-mediated signaling events	4.0	143.0	34.0	-0.164	0.04	1000.0	-1000.0	-0.021	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	291.0	68.0	-0.51	0.318	1000.0	-1000.0	-0.076	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	306.0	74.0	-0.122	0.078	1000.0	-1000.0	-0.051	-1000.0
IL23-mediated signaling events	4.0	282.0	60.0	-0.669	0.042	1000.0	-1000.0	-0.093	-1000.0
IL12-mediated signaling events	3.0	291.0	87.0	-0.4	0.076	1000.0	-1000.0	-0.046	-1000.0
PLK2 and PLK4 events	3.0	9.0	3.0	-0.022	-1000.0	1000.0	-1000.0	-0.001	-1000.0
Signaling events mediated by the Hedgehog family	3.0	177.0	52.0	-0.113	0.059	1000.0	-1000.0	-0.026	-1000.0
Thromboxane A2 receptor signaling	3.0	413.0	105.0	-0.254	0.056	1000.0	-1000.0	-0.031	-1000.0
Endothelins	3.0	340.0	96.0	-0.334	0.047	1000.0	-1000.0	-0.044	-1000.0
Syndecan-3-mediated signaling events	3.0	124.0	35.0	-0.123	0.078	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	412.0	125.0	-0.104	0.07	1000.0	-1000.0	-0.025	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	244.0	76.0	-0.14	0.064	1000.0	-1000.0	-0.051	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	280.0	136.0	-0.466	0.105	1000.0	-1000.0	-0.044	-1000.0
Visual signal transduction: Cones	2.0	77.0	38.0	-0.051	0.046	1000.0	-1000.0	-0.0	-1000.0
Osteopontin-mediated events	2.0	84.0	38.0	-0.079	0.04	1000.0	-1000.0	-0.022	-1000.0
Noncanonical Wnt signaling pathway	2.0	61.0	26.0	-0.041	0.04	1000.0	-1000.0	-0.051	-1000.0
HIF-1-alpha transcription factor network	2.0	191.0	76.0	-0.213	0.077	1000.0	-1000.0	-0.024	-1000.0
Arf6 signaling events	2.0	156.0	62.0	-0.066	0.091	1000.0	-1000.0	-0.012	-1000.0
EPO signaling pathway	2.0	127.0	55.0	0.0	0.091	1000.0	-1000.0	-0.018	-1000.0
PLK1 signaling events	2.0	247.0	85.0	-0.168	0.058	1000.0	-1000.0	-0.036	-1000.0
PDGFR-alpha signaling pathway	2.0	91.0	44.0	-0.209	0.051	1000.0	-1000.0	-0.028	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	177.0	82.0	-0.068	0.064	1000.0	-1000.0	-0.04	-1000.0
Ephrin B reverse signaling	2.0	132.0	48.0	-0.108	0.044	1000.0	-1000.0	-0.034	-1000.0
TCGA08_p53	2.0	14.0	7.0	-0.04	0.039	1000.0	-1000.0	-0.003	-1000.0
Nongenotropic Androgen signaling	2.0	134.0	52.0	-0.205	0.103	1000.0	-1000.0	-0.025	-1000.0
Wnt signaling	2.0	14.0	7.0	-0.029	0.039	1000.0	-1000.0	-0.001	-1000.0
IL6-mediated signaling events	2.0	159.0	75.0	-0.164	0.058	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by PRL	2.0	69.0	34.0	-0.185	0.04	1000.0	-1000.0	-0.026	-1000.0
Aurora B signaling	2.0	151.0	67.0	-0.158	0.06	1000.0	-1000.0	-0.041	-1000.0
Caspase cascade in apoptosis	1.0	114.0	74.0	-0.117	0.05	1000.0	-1000.0	-0.032	-1000.0
Coregulation of Androgen receptor activity	1.0	96.0	76.0	-0.078	0.07	1000.0	-1000.0	-0.018	-1000.0
ErbB4 signaling events	1.0	89.0	69.0	-0.103	0.055	1000.0	-1000.0	-0.022	-1000.0
BARD1 signaling events	1.0	59.0	57.0	-0.073	0.084	1000.0	-1000.0	-0.054	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	29.0	28.0	-0.044	0.053	1000.0	-1000.0	-0.007	-1000.0
Syndecan-2-mediated signaling events	1.0	92.0	69.0	-0.052	0.054	1000.0	-1000.0	-0.024	-1000.0
Cellular roles of Anthrax toxin	1.0	68.0	39.0	-0.179	0.042	1000.0	-1000.0	-0.018	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	76.0	61.0	-0.16	0.078	1000.0	-1000.0	-0.049	-1000.0
Aurora A signaling	1.0	83.0	60.0	-0.078	0.096	1000.0	-1000.0	-0.006	-1000.0
p75(NTR)-mediated signaling	1.0	154.0	125.0	-0.164	0.078	1000.0	-1000.0	-0.022	-1000.0
IL4-mediated signaling events	1.0	130.0	91.0	-0.536	0.282	1000.0	-1000.0	-0.109	-1000.0
BMP receptor signaling	1.0	122.0	81.0	-0.058	0.085	1000.0	-1000.0	-0.02	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	149.0	97.0	-0.08	0.067	1000.0	-1000.0	-0.062	-1000.0
amb2 Integrin signaling	1.0	115.0	82.0	-0.081	0.073	1000.0	-1000.0	-0.017	-1000.0
Nectin adhesion pathway	1.0	67.0	63.0	-0.122	0.086	1000.0	-1000.0	-0.048	-1000.0
Glucocorticoid receptor regulatory network	1.0	130.0	114.0	-0.284	0.088	1000.0	-1000.0	-0.046	-1000.0
Ceramide signaling pathway	1.0	77.0	76.0	-0.092	0.077	1000.0	-1000.0	-0.026	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	44.0	37.0	-0.074	0.076	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by HDAC Class III	1.0	71.0	40.0	-0.141	0.114	1000.0	-1000.0	-0.039	-1000.0
TRAIL signaling pathway	1.0	56.0	48.0	-0.0	0.075	1000.0	-1000.0	-0.018	-1000.0
IL1-mediated signaling events	1.0	121.0	62.0	-0.1	0.081	1000.0	-1000.0	-0.025	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	73.0	52.0	-0.254	0.12	1000.0	-1000.0	-0.019	-1000.0
S1P1 pathway	1.0	67.0	36.0	-0.132	0.04	1000.0	-1000.0	-0.034	-1000.0
FAS signaling pathway (CD95)	1.0	60.0	47.0	-0.038	0.055	1000.0	-1000.0	-0.04	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	74.0	44.0	-0.058	0.039	1000.0	-1000.0	-0.018	-1000.0
Integrins in angiogenesis	1.0	115.0	84.0	-0.071	0.096	1000.0	-1000.0	-0.033	-1000.0
TCR signaling in naïve CD8+ T cells	1.0	130.0	93.0	-0.138	0.164	1000.0	-1000.0	-0.025	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	47.0	45.0	-0.024	0.075	1000.0	-1000.0	-0.034	-1000.0
Canonical Wnt signaling pathway	1.0	70.0	51.0	-0.159	0.09	1000.0	-1000.0	-0.042	-1000.0
EPHB forward signaling	1.0	110.0	85.0	-0.053	0.081	1000.0	-1000.0	-0.04	-1000.0
Effects of Botulinum toxin	1.0	49.0	26.0	-0.138	0.068	1000.0	-1000.0	-0.002	-1000.0
Glypican 2 network	1.0	6.0	4.0	0.0	0.02	1000.0	-1000.0	0.0	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	41.0	31.0	-0.09	0.052	1000.0	-1000.0	-0.06	-1000.0
IL27-mediated signaling events	1.0	56.0	51.0	-0.093	0.063	1000.0	-1000.0	-0.054	-1000.0
LPA receptor mediated events	1.0	103.0	102.0	-0.133	0.061	1000.0	-1000.0	-0.089	-1000.0
Class I PI3K signaling events	1.0	114.0	73.0	-0.071	0.052	1000.0	-1000.0	-0.032	-1000.0
BCR signaling pathway	1.0	175.0	99.0	-0.097	0.055	1000.0	-1000.0	-0.057	-1000.0
EGFR-dependent Endothelin signaling events	1.0	28.0	21.0	-0.021	0.073	1000.0	-1000.0	-0.0	-1000.0
Syndecan-4-mediated signaling events	1.0	97.0	67.0	-0.088	0.053	1000.0	-1000.0	-0.03	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	127.0	88.0	-0.144	0.053	1000.0	-1000.0	-0.069	-1000.0
Rapid glucocorticoid signaling	1.0	28.0	20.0	-0.085	0.04	1000.0	-1000.0	-0.0	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	144.0	120.0	-0.139	0.111	1000.0	-1000.0	-0.048	-1000.0
Visual signal transduction: Rods	1.0	89.0	52.0	-0.055	0.056	1000.0	-1000.0	-0.01	-1000.0
E-cadherin signaling in keratinocytes	1.0	64.0	43.0	-0.121	0.044	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	137.0	78.0	-0.08	0.053	1000.0	-1000.0	-0.052	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	26.0	17.0	-0.033	0.034	1000.0	-1000.0	-0.024	-1000.0
LPA4-mediated signaling events	0.0	7.0	12.0	-0.052	0.011	1000.0	-1000.0	-0.018	-1000.0
ErbB2/ErbB3 signaling events	0.0	52.0	65.0	-0.059	0.053	1000.0	-1000.0	-0.084	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	5.0	23.0	-0.003	0.071	1000.0	-1000.0	-0.018	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	8.0	34.0	-0.042	0.083	1000.0	-1000.0	-0.028	-1000.0
Canonical NF-kappaB pathway	0.0	16.0	39.0	-0.024	0.097	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by HDAC Class II	0.0	33.0	75.0	-0.053	0.103	1000.0	-1000.0	-0.01	-1000.0
Circadian rhythm pathway	0.0	17.0	22.0	-0.066	0.065	1000.0	-1000.0	-0.04	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	0.0	33.0	54.0	-0.034	0.069	1000.0	-1000.0	-0.02	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	7.0	17.0	-0.001	0.065	1000.0	-1000.0	-0.013	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	4.0	5.0	0.017	0.04	1000.0	-1000.0	0.024	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	54.0	85.0	-0.323	0.076	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by PTP1B	0.0	65.0	76.0	-0.038	0.06	1000.0	-1000.0	-0.037	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	56.0	65.0	-0.04	0.076	1000.0	-1000.0	-0.027	-1000.0
Arf6 downstream pathway	0.0	13.0	43.0	-0.052	0.076	1000.0	-1000.0	-0.03	-1000.0
Aurora C signaling	0.0	3.0	7.0	0.0	0.058	1000.0	-1000.0	-0.001	-1000.0
FOXA2 and FOXA3 transcription factor networks	0.0	18.0	46.0	-0.075	0.057	1000.0	-1000.0	-0.046	-1000.0
Glypican 1 network	0.0	39.0	48.0	-0.04	0.073	1000.0	-1000.0	-0.021	-1000.0
Insulin-mediated glucose transport	0.0	9.0	32.0	-0.0	0.054	1000.0	-1000.0	-0.017	-1000.0
mTOR signaling pathway	0.0	31.0	53.0	-0.112	0.055	1000.0	-1000.0	-0.032	-1000.0
IFN-gamma pathway	0.0	40.0	68.0	-0.05	0.055	1000.0	-1000.0	-0.04	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	21.0	68.0	-0.036	0.062	1000.0	-1000.0	-0.023	-1000.0
Reelin signaling pathway	0.0	30.0	56.0	-0.04	0.102	1000.0	-1000.0	-0.022	-1000.0
S1P5 pathway	0.0	0.0	17.0	-0.011	0.04	1000.0	-1000.0	-0.007	-1000.0
ceramide signaling pathway	0.0	44.0	49.0	-0.024	0.057	1000.0	-1000.0	-0.028	-1000.0
HIF-2-alpha transcription factor network	0.0	30.0	43.0	-0.105	0.097	1000.0	-1000.0	-0.043	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	40.0	83.0	-0.018	0.082	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by HDAC Class I	0.0	33.0	104.0	-0.048	0.077	1000.0	-1000.0	-0.029	-1000.0
FoxO family signaling	0.0	30.0	64.0	-0.152	0.059	1000.0	-1000.0	-0.046	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	11.0	15.0	-0.044	0.039	1000.0	-1000.0	-0.029	-1000.0
Retinoic acid receptors-mediated signaling	0.0	35.0	58.0	-0.05	0.079	1000.0	-1000.0	-0.033	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	27.0	36.0	-0.074	0.075	1000.0	-1000.0	-0.031	-1000.0
Atypical NF-kappaB pathway	0.0	12.0	31.0	-0.006	0.055	1000.0	-1000.0	-0.008	-1000.0
IL2 signaling events mediated by PI3K	0.0	24.0	58.0	-0.013	0.068	1000.0	-1000.0	-0.035	-1000.0
Regulation of p38-alpha and p38-beta	0.0	43.0	54.0	-0.03	0.092	1000.0	-1000.0	-0.029	-1000.0
TCGA08_rtk_signaling	0.0	24.0	26.0	-0.032	0.048	1000.0	-1000.0	-0.005	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.0	0.092	1000.0	-1000.0	-0.019	-1000.0
IL2 signaling events mediated by STAT5	0.0	19.0	22.0	-0.068	0.041	1000.0	-1000.0	-0.029	-1000.0
Arf6 trafficking events	0.0	29.0	71.0	-0.048	0.052	1000.0	-1000.0	-0.03	-1000.0
Regulation of Telomerase	0.0	87.0	102.0	-0.133	0.098	1000.0	-1000.0	-0.053	-1000.0
IGF1 pathway	0.0	20.0	57.0	-0.033	0.097	1000.0	-1000.0	-0.027	-1000.0
Insulin Pathway	0.0	45.0	74.0	-0.034	0.084	1000.0	-1000.0	-0.022	-1000.0
Plasma membrane estrogen receptor signaling	0.0	73.0	86.0	-0.033	0.066	1000.0	-1000.0	-0.046	-1000.0
VEGFR1 specific signals	0.0	10.0	56.0	-0.014	0.085	1000.0	-1000.0	-0.032	-1000.0
S1P3 pathway	0.0	15.0	42.0	-0.039	0.053	1000.0	-1000.0	-0.03	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	16.0	33.0	-0.047	0.093	1000.0	-1000.0	-0.027	-1000.0
PDGFR-beta signaling pathway	0.0	88.0	97.0	-0.076	0.111	1000.0	-1000.0	-0.029	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.037	0.037	1000.0	-1000.0	-0.024	-1000.0
S1P4 pathway	0.0	3.0	25.0	-0.0	0.053	1000.0	-1000.0	-0.01	-1000.0
p38 MAPK signaling pathway	0.0	36.0	44.0	-0.03	0.072	1000.0	-1000.0	-0.015	-1000.0
Arf1 pathway	0.0	4.0	54.0	-0.002	0.049	1000.0	-1000.0	-0.011	-1000.0
Alternative NF-kappaB pathway	0.0	6.0	13.0	-0.0	0.059	1000.0	-1000.0	-0.0	-1000.0
Regulation of Androgen receptor activity	0.0	54.0	70.0	-0.168	0.068	1000.0	-1000.0	-0.056	-1000.0
Total	142	11014	7203	-13.8045440118	-990.882939177	131000	-131000	-3.92771792314	-131000