Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.004 0.088 -9999.0 0.0 -0.285 11.0 11.0 epithelial cell differentiation 0.04 0.092 -9999.0 0.0 -0.265 11.0 11.0 CYFIP2 0.028 0.048 -9999.0 0.0 -0.506 1.0 1.0 ENAH -0.001 0.116 0.264 5.0 -0.329 5.0 10.0 EGFR -0.03 0.169 -9999.0 0.0 -0.506 17.0 17.0 EPHA2 -0.012 0.146 -9999.0 0.0 -0.506 12.0 12.0 MYO6 -0.007 0.09 -9999.0 0.0 -0.281 13.0 13.0 CTNNB1 0.031 0.019 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.055 0.055 -9999.0 0.0 -0.315 2.0 2.0 AQP5 -0.084 0.188 -9999.0 0.0 -0.503 23.0 23.0 CTNND1 0.02 0.096 -9999.0 0.0 -0.506 5.0 5.0 mol:PI-4-5-P2 -0.006 0.076 -9999.0 0.0 -0.254 12.0 12.0 regulation of calcium-dependent cell-cell adhesion -0.018 0.097 -9999.0 0.0 -0.29 14.0 14.0 EGF -0.032 0.152 -9999.0 0.0 -0.506 13.0 13.0 NCKAP1 0.03 0.049 -9999.0 0.0 -0.506 1.0 1.0 AQP3 -0.113 0.202 -9999.0 0.0 -0.501 30.0 30.0 cortical microtubule organization 0.04 0.092 -9999.0 0.0 -0.265 11.0 11.0 GO:0000145 -0.027 0.067 -9999.0 0.0 -0.244 11.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.046 0.095 -9999.0 0.0 -0.268 11.0 11.0 MLLT4 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.052 0.103 -9999.0 0.0 -0.422 7.0 7.0 ARF6 0.028 0.063 -9999.0 0.0 -0.506 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.023 0.12 -9999.0 0.0 -0.366 10.0 10.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.013 0.063 -9999.0 0.0 -0.39 1.0 1.0 PVRL2 0.031 0.046 -9999.0 0.0 -0.506 1.0 1.0 ZYX -0.008 0.081 -9999.0 0.0 -0.257 13.0 13.0 ARF6/GTP 0.024 0.127 -9999.0 0.0 -0.368 10.0 10.0 CDH1 0.013 0.106 -9999.0 0.0 -0.506 6.0 6.0 EGFR/EGFR/EGF/EGF -0.038 0.156 -9999.0 0.0 -0.323 30.0 30.0 RhoA/GDP 0.042 0.09 -9999.0 0.0 -0.252 11.0 11.0 actin cytoskeleton organization -0.032 0.094 -9999.0 0.0 -0.327 10.0 10.0 IGF-1R heterotetramer -0.004 0.14 -9999.0 0.0 -0.505 11.0 11.0 GIT1 0.028 0.063 -9999.0 0.0 -0.506 2.0 2.0 IGF1R -0.004 0.14 -9999.0 0.0 -0.506 11.0 11.0 IGF1 -0.047 0.182 -9999.0 0.0 -0.506 20.0 20.0 DIAPH1 0.012 0.195 -9999.0 0.0 -0.709 5.0 5.0 Wnt receptor signaling pathway -0.04 0.092 0.265 11.0 -9999.0 0.0 11.0 RHOA 0.033 0.013 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.05 0.095 -9999.0 0.0 -0.41 6.0 6.0 CTNNA1 0.035 0.009 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.033 0.097 -9999.0 0.0 -0.336 10.0 10.0 EFNA1 0.022 0.077 -9999.0 0.0 -0.506 3.0 3.0 LPP -0.021 0.059 -9999.0 0.0 -0.267 3.0 3.0 Ephrin A1/EPHA2 0.001 0.131 -9999.0 0.0 -0.302 21.0 21.0 SEC6/SEC8 -0.005 0.071 -9999.0 0.0 -0.301 1.0 1.0 MGAT3 -0.019 0.098 -9999.0 0.0 -0.295 14.0 14.0 HGF/MET 0.027 0.092 -9999.0 0.0 -0.253 12.0 12.0 HGF 0.033 0.022 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.004 0.089 -9999.0 0.0 -0.287 11.0 11.0 actin cable formation 0.047 0.129 0.28 9.0 -0.36 3.0 12.0 KIAA1543 -0.032 0.076 -9999.0 0.0 -0.29 1.0 1.0 KIFC3 -0.003 0.076 -9999.0 0.0 -0.259 10.0 10.0 NCK1 0.025 0.046 -9999.0 0.0 -0.506 1.0 1.0 EXOC3 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.003 0.076 -9999.0 0.0 -0.262 10.0 10.0 NCK1/GIT1 0.031 0.062 -9999.0 0.0 -0.368 3.0 3.0 mol:GDP 0.04 0.092 -9999.0 0.0 -0.265 11.0 11.0 EXOC4 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.028 0.063 -9999.0 0.0 -0.254 11.0 11.0 PIP5K1C -0.006 0.077 -9999.0 0.0 -0.257 12.0 12.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.0 0.133 0.295 5.0 -0.386 5.0 10.0 adherens junction assembly -0.027 0.117 -9999.0 0.0 -0.661 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.034 0.148 -9999.0 0.0 -0.285 34.0 34.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.047 0.039 -9999.0 0.0 -0.368 1.0 1.0 MET 0.024 0.076 -9999.0 0.0 -0.506 3.0 3.0 PLEKHA7 -0.002 0.077 -9999.0 0.0 -0.259 10.0 10.0 mol:GTP 0.021 0.119 -9999.0 0.0 -0.363 10.0 10.0 establishment of epithelial cell apical/basal polarity -0.03 0.065 -9999.0 0.0 -0.291 1.0 1.0 cortical actin cytoskeleton stabilization -0.004 0.088 -9999.0 0.0 -0.285 11.0 11.0 regulation of cell-cell adhesion -0.032 0.094 -9999.0 0.0 -0.327 10.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.004 0.089 -9999.0 0.0 -0.287 11.0 11.0