E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.04 0.146 -9999.0 0.0 -0.336 97.0 97.0 KLHL20 -0.015 0.1 0.2 13.0 -0.229 51.0 64.0 CYFIP2 0.038 0.011 -9999.0 0.0 0.0 45.0 45.0 Rac1/GDP -0.012 0.107 0.268 5.0 -0.251 48.0 53.0 ENAH -0.038 0.144 -9999.0 0.0 -0.334 95.0 95.0 AP1M1 0.036 0.015 -9999.0 0.0 0.0 78.0 78.0 RAP1B 0.038 0.013 -9999.0 0.0 0.0 57.0 57.0 RAP1A 0.039 0.01 -9999.0 0.0 0.0 35.0 35.0 CTNNB1 0.039 0.01 -9999.0 0.0 0.0 32.0 32.0 CDC42/GTP 0.002 0.08 0.158 4.0 -0.197 34.0 38.0 ABI1/Sra1/Nap1 -0.032 0.053 -9999.0 0.0 -0.156 60.0 60.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.068 0.068 -9999.0 0.0 -0.111 44.0 44.0 RAPGEF1 -0.037 0.13 0.28 3.0 -0.304 87.0 90.0 CTNND1 0.041 0.007 -9999.0 0.0 0.0 17.0 17.0 regulation of calcium-dependent cell-cell adhesion -0.03 0.155 -9999.0 0.0 -0.336 101.0 101.0 CRK -0.034 0.137 0.25 1.0 -0.324 86.0 87.0 E-cadherin/gamma catenin/alpha catenin 0.05 0.065 -9999.0 0.0 -0.136 42.0 42.0 alphaE/beta7 Integrin 0.05 0.038 -9999.0 0.0 -0.134 17.0 17.0 IQGAP1 0.037 0.014 -9999.0 0.0 0.0 67.0 67.0 NCKAP1 0.039 0.01 -9999.0 0.0 0.0 33.0 33.0 Rap1/GTP/I-afadin 0.042 0.065 -9999.0 0.0 -0.112 64.0 64.0 DLG1 -0.044 0.15 -9999.0 0.0 -0.339 102.0 102.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.034 0.048 -9999.0 0.0 -0.147 55.0 55.0 MLLT4 0.033 0.017 -9999.0 0.0 0.0 110.0 110.0 ARF6/GTP/NME1/Tiam1 0.046 0.062 -9999.0 0.0 -0.109 57.0 57.0 PI3K -0.04 0.063 -9999.0 0.0 -0.191 53.0 53.0 ARF6 0.04 0.007 -9999.0 0.0 0.0 18.0 18.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.038 0.052 -9999.0 0.0 -0.149 30.0 30.0 TIAM1 0.037 0.014 -9999.0 0.0 0.0 70.0 70.0 E-cadherin(dimer)/Ca2+ 0.063 0.072 -9999.0 0.0 -0.127 51.0 51.0 AKT1 -0.008 0.062 0.157 15.0 -0.152 21.0 36.0 PIK3R1 0.034 0.016 -9999.0 0.0 0.0 106.0 106.0 CDH1 0.035 0.016 -9999.0 0.0 0.0 96.0 96.0 RhoA/GDP -0.013 0.107 0.247 2.0 -0.252 49.0 51.0 actin cytoskeleton organization -0.009 0.076 0.166 13.0 -0.168 49.0 62.0 CDC42/GDP -0.012 0.107 0.28 4.0 -0.253 48.0 52.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.002 0.073 -9999.0 0.0 -0.193 55.0 55.0 ITGB7 0.039 0.011 -9999.0 0.0 0.0 39.0 39.0 RAC1 0.039 0.01 -9999.0 0.0 0.0 35.0 35.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.068 0.078 -9999.0 0.0 -0.136 51.0 51.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.046 0.056 -9999.0 0.0 -0.108 48.0 48.0 mol:GDP -0.031 0.111 0.278 4.0 -0.286 49.0 53.0 CDC42/GTP/IQGAP1 0.04 0.046 -9999.0 0.0 -0.114 40.0 40.0 JUP 0.037 0.014 -9999.0 0.0 0.0 67.0 67.0 p120 catenin/RhoA/GDP -0.001 0.115 0.285 1.0 -0.265 45.0 46.0 RAC1/GTP/IQGAP1 0.038 0.046 -9999.0 0.0 -0.113 40.0 40.0 PIP5K1C/AP1M1 0.048 0.027 -9999.0 0.0 -0.136 1.0 1.0 RHOA 0.041 0.007 -9999.0 0.0 0.0 14.0 14.0 CDC42 0.04 0.008 -9999.0 0.0 0.0 22.0 22.0 CTNNA1 0.039 0.01 -9999.0 0.0 0.0 36.0 36.0 positive regulation of S phase of mitotic cell cycle -0.015 0.059 0.125 4.0 -0.121 96.0 100.0 NME1 0.035 0.015 -9999.0 0.0 0.0 87.0 87.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.039 0.147 -9999.0 0.0 -0.343 93.0 93.0 regulation of cell-cell adhesion -0.009 0.065 -9999.0 0.0 -0.152 54.0 54.0 WASF2 -0.006 0.042 0.098 12.0 -0.091 47.0 59.0 Rap1/GTP 0.001 0.087 0.19 20.0 -0.231 28.0 48.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.072 0.082 -9999.0 0.0 -0.122 49.0 49.0 CCND1 -0.019 0.071 0.143 4.0 -0.148 96.0 100.0 VAV2 -0.047 0.211 -9999.0 0.0 -0.625 44.0 44.0 RAP1/GDP -0.0 0.098 0.223 11.0 -0.255 30.0 41.0 adherens junction assembly -0.039 0.143 -9999.0 0.0 -0.333 94.0 94.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.04 0.009 -9999.0 0.0 0.0 28.0 28.0 PIP5K1C 0.037 0.013 -9999.0 0.0 0.0 63.0 63.0 regulation of heterotypic cell-cell adhesion 0.046 0.076 0.219 6.0 -0.126 58.0 64.0 E-cadherin/beta catenin 0.007 0.04 0.146 1.0 -0.227 12.0 13.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.038 0.142 -9999.0 0.0 -0.332 94.0 94.0 PIK3CA 0.03 0.019 -9999.0 0.0 0.0 150.0 150.0 Rac1/GTP -0.054 0.13 -9999.0 0.0 -0.354 61.0 61.0 E-cadherin/beta catenin/alpha catenin 0.052 0.065 -9999.0 0.0 -0.13 48.0 48.0 ITGAE 0.039 0.01 -9999.0 0.0 0.0 34.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.031 0.158 -9999.0 0.0 -0.343 101.0 101.0