Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.086 0.162 -9999.0 0.0 -0.537 4.0 4.0 IHH -0.129 0.18 -9999.0 0.0 -0.367 18.0 18.0 SHH Np/Cholesterol/GAS1 -0.042 0.087 -9999.0 0.0 -0.182 14.0 14.0 LRPAP1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.042 0.086 0.181 14.0 -9999.0 0.0 14.0 SMO/beta Arrestin2 -0.098 0.184 -9999.0 0.0 -0.339 16.0 16.0 SMO -0.118 0.181 -9999.0 0.0 -0.341 18.0 18.0 AKT1 -0.05 0.144 -9999.0 0.0 -0.533 3.0 3.0 ARRB2 0.028 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.019 0.031 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.116 0.178 -9999.0 0.0 -0.336 18.0 18.0 STIL -0.061 0.145 0.177 4.0 -0.273 12.0 16.0 DHH N/PTCH2 0.043 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.068 0.12 -9999.0 0.0 -0.227 18.0 18.0 PIK3CA 0.02 0.052 -9999.0 0.0 -0.35 1.0 1.0 DHH 0.03 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.122 0.196 -9999.0 0.0 -0.466 9.0 9.0 determination of left/right symmetry -0.116 0.178 -9999.0 0.0 -0.336 18.0 18.0 PIK3R1 0.0 0.09 -9999.0 0.0 -0.35 3.0 3.0 skeletal system development -0.121 0.195 -9999.0 0.0 -0.463 9.0 9.0 IHH N/Hhip -0.1 0.142 -9999.0 0.0 -0.264 20.0 20.0 DHH N/Hhip 0.0 0.093 -9999.0 0.0 -0.246 6.0 6.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.116 0.178 -9999.0 0.0 -0.336 18.0 18.0 pancreas development -0.024 0.12 -9999.0 0.0 -0.349 6.0 6.0 HHAT -0.026 0.127 -9999.0 0.0 -0.35 7.0 7.0 PI3K 0.014 0.087 -9999.0 0.0 -0.312 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.048 0.14 -9999.0 0.0 -0.35 9.0 9.0 somite specification -0.116 0.178 -9999.0 0.0 -0.336 18.0 18.0 SHH Np/Cholesterol/PTCH1 -0.082 0.127 -9999.0 0.0 -0.25 17.0 17.0 SHH Np/Cholesterol/PTCH2 -0.006 0.069 -9999.0 0.0 -0.181 7.0 7.0 SHH Np/Cholesterol/Megalin -0.009 0.071 -9999.0 0.0 -0.184 7.0 7.0 SHH -0.032 0.069 -9999.0 0.0 -0.246 5.0 5.0 catabolic process -0.092 0.126 -9999.0 0.0 -0.252 19.0 19.0 SMO/Vitamin D3 -0.087 0.172 0.194 2.0 -0.316 16.0 18.0 SHH Np/Cholesterol/Hhip -0.032 0.09 -9999.0 0.0 -0.196 11.0 11.0 LRP2 0.022 0.026 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.084 0.173 0.172 2.0 -0.321 15.0 17.0 SHH Np/Cholesterol/BOC -0.006 0.066 -9999.0 0.0 -0.184 6.0 6.0 SHH Np/Cholesterol/CDO -0.009 0.071 -9999.0 0.0 -0.184 7.0 7.0 mesenchymal cell differentiation 0.032 0.089 0.195 11.0 -9999.0 0.0 11.0 mol:Vitamin D3 -0.068 0.142 0.191 3.0 -0.251 17.0 20.0 IHH N/PTCH2 -0.064 0.113 -9999.0 0.0 -0.226 16.0 16.0 CDON 0.024 0.023 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.083 0.133 -9999.0 0.0 -0.254 19.0 19.0 Megalin/LRPAP1 0.036 0.026 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.029 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.012 0.065 -9999.0 0.0 -0.177 7.0 7.0 PTCH1 -0.092 0.126 -9999.0 0.0 -0.253 19.0 19.0 HHIP -0.024 0.12 -9999.0 0.0 -0.35 6.0 6.0