Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	9.0	478.0	52.0	-0.129	0.043	1000.0	-1000.0	-0.024	-1000.0
HIF-1-alpha transcription factor network	8.0	664.0	76.0	-0.265	0.034	1000.0	-1000.0	-0.028	-1000.0
Ephrin B reverse signaling	8.0	401.0	48.0	-0.225	0.03	1000.0	-1000.0	-0.028	-1000.0
PLK2 and PLK4 events	6.0	20.0	3.0	-0.06	0.023	1000.0	-1000.0	-0.021	-1000.0
Noncanonical Wnt signaling pathway	6.0	159.0	26.0	-0.081	0.031	1000.0	-1000.0	-0.045	-1000.0
TCGA08_retinoblastoma	6.0	48.0	8.0	-0.038	0.022	1000.0	-1000.0	-0.005	-1000.0
IGF1 pathway	6.0	353.0	57.0	-0.065	0.052	1000.0	-1000.0	-0.029	-1000.0
FOXM1 transcription factor network	6.0	346.0	51.0	-0.432	0.031	1000.0	-1000.0	-0.084	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	6.0	525.0	78.0	-0.235	0.089	1000.0	-1000.0	-0.045	-1000.0
Osteopontin-mediated events	5.0	196.0	38.0	-0.104	0.031	1000.0	-1000.0	-0.019	-1000.0
IL4-mediated signaling events	5.0	492.0	91.0	-0.579	0.388	1000.0	-1000.0	-0.077	-1000.0
Glypican 1 network	5.0	263.0	48.0	-0.061	0.033	1000.0	-1000.0	-0.019	-1000.0
Nectin adhesion pathway	5.0	343.0	63.0	-0.086	0.065	1000.0	-1000.0	-0.029	-1000.0
Endothelins	5.0	529.0	96.0	-0.17	0.038	1000.0	-1000.0	-0.029	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	5.0	363.0	68.0	-0.205	0.122	1000.0	-1000.0	-0.05	-1000.0
Plasma membrane estrogen receptor signaling	5.0	499.0	86.0	-0.16	0.151	1000.0	-1000.0	-0.035	-1000.0
IL12-mediated signaling events	4.0	416.0	87.0	-0.264	0.05	1000.0	-1000.0	-0.034	-1000.0
TCGA08_p53	4.0	29.0	7.0	-0.038	0.021	1000.0	-1000.0	-0.003	-1000.0
Wnt signaling	4.0	33.0	7.0	-0.076	0.026	1000.0	-1000.0	-0.008	-1000.0
IL23-mediated signaling events	4.0	299.0	60.0	-0.328	0.031	1000.0	-1000.0	-0.063	-1000.0
Caspase cascade in apoptosis	3.0	254.0	74.0	-0.043	0.041	1000.0	-1000.0	-0.028	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	428.0	136.0	-0.427	0.071	1000.0	-1000.0	-0.034	-1000.0
Syndecan-1-mediated signaling events	3.0	123.0	34.0	-0.088	0.039	1000.0	-1000.0	-0.019	-1000.0
Thromboxane A2 receptor signaling	3.0	343.0	105.0	-0.094	0.049	1000.0	-1000.0	-0.031	-1000.0
BMP receptor signaling	3.0	254.0	81.0	-0.101	0.051	1000.0	-1000.0	-0.02	-1000.0
FAS signaling pathway (CD95)	3.0	156.0	47.0	-0.085	0.037	1000.0	-1000.0	-0.024	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	173.0	44.0	-0.068	0.031	1000.0	-1000.0	-0.015	-1000.0
EPHB forward signaling	3.0	328.0	85.0	-0.082	0.056	1000.0	-1000.0	-0.048	-1000.0
Glypican 2 network	3.0	15.0	4.0	-0.008	-0.0	1000.0	-1000.0	-0.0	-1000.0
Nongenotropic Androgen signaling	3.0	175.0	52.0	-0.102	0.049	1000.0	-1000.0	-0.021	-1000.0
LPA receptor mediated events	3.0	318.0	102.0	-0.099	0.03	1000.0	-1000.0	-0.051	-1000.0
Syndecan-4-mediated signaling events	3.0	212.0	67.0	-0.063	0.04	1000.0	-1000.0	-0.027	-1000.0
VEGFR1 specific signals	3.0	199.0	56.0	-0.058	0.031	1000.0	-1000.0	-0.03	-1000.0
Coregulation of Androgen receptor activity	2.0	207.0	76.0	-0.125	0.052	1000.0	-1000.0	-0.018	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	2.0	70.0	34.0	-0.023	0.078	1000.0	-1000.0	-0.022	-1000.0
Visual signal transduction: Cones	2.0	83.0	38.0	-0.015	0.046	1000.0	-1000.0	-0.003	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	38.0	17.0	-0.038	0.05	1000.0	-1000.0	-0.015	-1000.0
Syndecan-2-mediated signaling events	2.0	139.0	69.0	-0.037	0.044	1000.0	-1000.0	-0.027	-1000.0
Cellular roles of Anthrax toxin	2.0	113.0	39.0	-0.054	0.03	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by PTP1B	2.0	183.0	76.0	-0.077	0.042	1000.0	-1000.0	-0.023	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	190.0	65.0	-0.329	0.071	1000.0	-1000.0	-0.035	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	144.0	61.0	-0.089	0.06	1000.0	-1000.0	-0.034	-1000.0
FOXA2 and FOXA3 transcription factor networks	2.0	125.0	46.0	-0.168	0.036	1000.0	-1000.0	-0.055	-1000.0
Fc-epsilon receptor I signaling in mast cells	2.0	245.0	97.0	-0.059	0.045	1000.0	-1000.0	-0.044	-1000.0
PDGFR-alpha signaling pathway	2.0	115.0	44.0	-0.14	0.039	1000.0	-1000.0	-0.027	-1000.0
mTOR signaling pathway	2.0	128.0	53.0	-0.023	0.037	1000.0	-1000.0	-0.029	-1000.0
IFN-gamma pathway	2.0	150.0	68.0	-0.053	0.042	1000.0	-1000.0	-0.042	-1000.0
Ceramide signaling pathway	2.0	155.0	76.0	-0.047	0.07	1000.0	-1000.0	-0.024	-1000.0
Reelin signaling pathway	2.0	162.0	56.0	-0.045	0.052	1000.0	-1000.0	-0.023	-1000.0
TRAIL signaling pathway	2.0	105.0	48.0	-0.036	0.037	1000.0	-1000.0	-0.025	-1000.0
IL1-mediated signaling events	2.0	148.0	62.0	-0.053	0.066	1000.0	-1000.0	-0.026	-1000.0
ceramide signaling pathway	2.0	121.0	49.0	-0.037	0.044	1000.0	-1000.0	-0.026	-1000.0
HIF-2-alpha transcription factor network	2.0	115.0	43.0	-0.054	0.055	1000.0	-1000.0	-0.032	-1000.0
S1P1 pathway	2.0	99.0	36.0	-0.111	0.028	1000.0	-1000.0	-0.027	-1000.0
Retinoic acid receptors-mediated signaling	2.0	148.0	58.0	-0.102	0.059	1000.0	-1000.0	-0.025	-1000.0
Syndecan-3-mediated signaling events	2.0	72.0	35.0	-0.059	0.059	1000.0	-1000.0	-0.023	-1000.0
IL2 signaling events mediated by PI3K	2.0	134.0	58.0	-0.101	0.031	1000.0	-1000.0	-0.026	-1000.0
Integrins in angiogenesis	2.0	207.0	84.0	-0.087	0.061	1000.0	-1000.0	-0.03	-1000.0
TCR signaling in naïve CD8+ T cells	2.0	219.0	93.0	-0.034	0.041	1000.0	-1000.0	-0.033	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	95.0	45.0	-0.038	0.047	1000.0	-1000.0	-0.035	-1000.0
Canonical Wnt signaling pathway	2.0	135.0	51.0	-0.089	0.072	1000.0	-1000.0	-0.026	-1000.0
IL27-mediated signaling events	2.0	140.0	51.0	-0.106	0.055	1000.0	-1000.0	-0.039	-1000.0
IL6-mediated signaling events	2.0	213.0	75.0	-0.078	0.063	1000.0	-1000.0	-0.045	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	177.0	74.0	-0.061	0.055	1000.0	-1000.0	-0.053	-1000.0
Class I PI3K signaling events	2.0	148.0	73.0	-0.029	0.042	1000.0	-1000.0	-0.019	-1000.0
Visual signal transduction: Rods	2.0	108.0	52.0	-0.078	0.066	1000.0	-1000.0	-0.016	-1000.0
E-cadherin signaling in keratinocytes	2.0	102.0	43.0	-0.032	0.046	1000.0	-1000.0	-0.019	-1000.0
S1P4 pathway	2.0	52.0	25.0	-0.027	0.04	1000.0	-1000.0	-0.012	-1000.0
Regulation of Androgen receptor activity	2.0	207.0	70.0	-0.146	0.034	1000.0	-1000.0	-0.029	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	36.0	17.0	-0.016	0.048	1000.0	-1000.0	-0.016	-1000.0
Aurora B signaling	2.0	163.0	67.0	-0.06	0.043	1000.0	-1000.0	-0.028	-1000.0
LPA4-mediated signaling events	1.0	23.0	12.0	-0.028	0.008	1000.0	-1000.0	-0.021	-1000.0
ErbB2/ErbB3 signaling events	1.0	66.0	65.0	-0.044	0.068	1000.0	-1000.0	-0.052	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	34.0	28.0	-0.024	0.04	1000.0	-1000.0	-0.022	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	1.0	75.0	54.0	-0.036	0.043	1000.0	-1000.0	-0.026	-1000.0
Ephrin A  reverse signaling	1.0	8.0	7.0	-0.002	0.035	1000.0	-1000.0	0.0	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	7.0	5.0	0.012	0.03	1000.0	-1000.0	0.018	-1000.0
Arf6 signaling events	1.0	93.0	62.0	-0.008	0.047	1000.0	-1000.0	-0.007	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	126.0	85.0	-0.13	0.058	1000.0	-1000.0	-0.041	-1000.0
Aurora A signaling	1.0	68.0	60.0	-0.043	0.063	1000.0	-1000.0	-0.023	-1000.0
p75(NTR)-mediated signaling	1.0	246.0	125.0	-0.088	0.066	1000.0	-1000.0	-0.042	-1000.0
EPO signaling pathway	1.0	86.0	55.0	-0.074	0.04	1000.0	-1000.0	-0.021	-1000.0
PLK1 signaling events	1.0	136.0	85.0	-0.032	0.032	1000.0	-1000.0	-0.024	-1000.0
amb2 Integrin signaling	1.0	152.0	82.0	-0.027	0.067	1000.0	-1000.0	-0.024	-1000.0
Glucocorticoid receptor regulatory network	1.0	194.0	114.0	-0.138	0.079	1000.0	-1000.0	-0.047	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	57.0	37.0	-0.026	0.051	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by HDAC Class III	1.0	70.0	40.0	-0.055	0.056	1000.0	-1000.0	-0.033	-1000.0
S1P5 pathway	1.0	30.0	17.0	-0.024	0.029	1000.0	-1000.0	-0.004	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	73.0	52.0	-0.056	0.07	1000.0	-1000.0	-0.033	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	98.0	83.0	-0.034	0.058	1000.0	-1000.0	-0.016	-1000.0
FoxO family signaling	1.0	74.0	64.0	-0.042	0.039	1000.0	-1000.0	-0.031	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	28.0	15.0	-0.027	0.028	1000.0	-1000.0	-0.027	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	47.0	36.0	-0.049	0.054	1000.0	-1000.0	-0.025	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	50.0	31.0	-0.038	0.04	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	195.0	125.0	-0.026	0.051	1000.0	-1000.0	-0.022	-1000.0
TCGA08_rtk_signaling	1.0	34.0	26.0	-0.037	0.044	1000.0	-1000.0	-0.001	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	140.0	76.0	-0.039	0.06	1000.0	-1000.0	-0.045	-1000.0
IL2 signaling events mediated by STAT5	1.0	41.0	22.0	-0.072	0.039	1000.0	-1000.0	-0.03	-1000.0
Regulation of Telomerase	1.0	120.0	102.0	-0.065	0.061	1000.0	-1000.0	-0.044	-1000.0
BCR signaling pathway	1.0	194.0	99.0	-0.036	0.057	1000.0	-1000.0	-0.034	-1000.0
EGFR-dependent Endothelin signaling events	1.0	30.0	21.0	-0.003	0.041	1000.0	-1000.0	-0.014	-1000.0
Insulin Pathway	1.0	123.0	74.0	-0.046	0.064	1000.0	-1000.0	-0.036	-1000.0
S1P3 pathway	1.0	66.0	42.0	-0.029	0.04	1000.0	-1000.0	-0.024	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	175.0	120.0	-0.027	0.083	1000.0	-1000.0	-0.032	-1000.0
PDGFR-beta signaling pathway	1.0	156.0	97.0	-0.046	0.062	1000.0	-1000.0	-0.042	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	0.016	0.046	1000.0	-1000.0	0.015	-1000.0
p38 MAPK signaling pathway	1.0	57.0	44.0	-0.052	0.052	1000.0	-1000.0	-0.009	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	18.0	23.0	-0.004	0.04	1000.0	-1000.0	-0.019	-1000.0
Canonical NF-kappaB pathway	0.0	19.0	39.0	-0.01	0.066	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by HDAC Class II	0.0	59.0	75.0	-0.065	0.071	1000.0	-1000.0	-0.024	-1000.0
ErbB4 signaling events	0.0	33.0	69.0	-0.038	0.055	1000.0	-1000.0	-0.035	-1000.0
BARD1 signaling events	0.0	51.0	57.0	-0.058	0.07	1000.0	-1000.0	-0.027	-1000.0
Circadian rhythm pathway	0.0	6.0	22.0	-0.01	0.06	1000.0	-1000.0	-0.018	-1000.0
Arf6 downstream pathway	0.0	29.0	43.0	-0.041	0.054	1000.0	-1000.0	-0.026	-1000.0
Aurora C signaling	0.0	5.0	7.0	-0.0	0.04	1000.0	-1000.0	-0.011	-1000.0
Insulin-mediated glucose transport	0.0	23.0	32.0	-0.025	0.037	1000.0	-1000.0	-0.025	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	49.0	68.0	-0.043	0.057	1000.0	-1000.0	-0.026	-1000.0
Signaling events regulated by Ret tyrosine kinase	0.0	81.0	82.0	-0.022	0.05	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by HDAC Class I	0.0	68.0	104.0	-0.035	0.07	1000.0	-1000.0	-0.023	-1000.0
Atypical NF-kappaB pathway	0.0	24.0	31.0	-0.012	0.031	1000.0	-1000.0	-0.026	-1000.0
Regulation of p38-alpha and p38-beta	0.0	49.0	54.0	-0.024	0.07	1000.0	-1000.0	-0.016	-1000.0
Effects of Botulinum toxin	0.0	6.0	26.0	-0.004	0.046	1000.0	-1000.0	-0.001	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	13.0	27.0	-0.017	0.069	1000.0	-1000.0	-0.029	-1000.0
Arf6 trafficking events	0.0	27.0	71.0	-0.05	0.053	1000.0	-1000.0	-0.024	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	84.0	88.0	-0.044	0.049	1000.0	-1000.0	-0.058	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	28.0	33.0	-0.044	0.066	1000.0	-1000.0	-0.027	-1000.0
Rapid glucocorticoid signaling	0.0	8.0	20.0	-0.003	0.038	1000.0	-1000.0	-0.001	-1000.0
Signaling events mediated by PRL	0.0	24.0	34.0	-0.03	0.044	1000.0	-1000.0	-0.036	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.03	0.03	1000.0	-1000.0	-0.019	-1000.0
Arf1 pathway	0.0	10.0	54.0	-0.001	0.053	1000.0	-1000.0	-0.017	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	0.0	0.069	1000.0	-1000.0	0.0	-1000.0
Total	263	18520	7203	-9.75846604845	6.80513886087	131000	-131000	-3.48813838101	-131000