rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AKT1(12), AKT2(1), AKT3(3), APAF1(1), ATM(12), BAD(1), BID(4), CAPN1(3), CAPN2(2), CASP6(2), CASP8(3), CSF2RB(2), DFFB(2), FAS(1), FASLG(1), IKBKB(3), IL1A(1), IL1R1(1), IL1RAP(2), IL3RA(1), IRAK1(1), IRAK2(3), IRAK3(1), IRAK4(2), NFKB1(1), NFKB2(3), NFKBIA(1), NTRK1(3), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PPP3CA(3), PPP3CB(3), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RELA(1), RIPK1(3), TNFRSF10D(1), TNFRSF1A(1), TP53(189)	64465557	493	361	245	28	43	129	50	162	108	1	<1.00e-15	<1.00e-15	<8.56e-15
2	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(4), E2F1(2), MDM2(2), MYC(1), PIK3CA(194), PIK3R1(14), POLR1A(2), POLR1B(2), POLR1C(2), POLR1D(2), RB1(10), TP53(189)	14816568	424	336	186	11	35	97	37	151	104	0	<1.00e-15	<1.00e-15	<8.56e-15
3	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(4), ATM(12), BUB1(1), CCNA2(2), CCNB1(2), CCNB3(6), CCND3(3), CCNE1(1), CDAN1(1), CDC25A(1), CDC25B(3), CDC25C(1), CDC7(1), CDH1(33), CDK2(1), CHEK2(2), DTX4(1), E2F1(2), E2F3(1), E2F4(2), E2F5(1), EP300(3), ESPL1(7), HDAC1(2), HDAC2(3), HDAC3(2), HDAC4(1), HDAC5(2), HDAC6(3), HDAC8(3), MAD2L1(2), MAD2L2(1), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), MDM2(2), ORC1L(1), ORC2L(1), ORC3L(1), PLK1(2), PRKDC(8), PTPRA(1), PTTG2(1), RB1(10), RBL1(1), SMAD4(1), TBC1D8(1), TFDP1(1), TP53(189), WEE1(1)	85526844	339	272	260	32	44	45	50	62	137	1	1.14e-10	<1.00e-15	<8.56e-15
4	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT1(12), AKT2(1), AKT3(3), CASP8(3), CD14(1), CD40(1), CD86(2), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), IFNAR1(1), IFNAR2(1), IFNB1(1), IKBKB(3), IKBKE(1), IL12A(1), IL12B(1), IL6(2), IRAK1(1), IRAK4(2), IRF3(2), JUN(1), LBP(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K4(21), MAP2K7(1), MAP3K7(1), MAP3K8(2), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(1), NFKB2(3), NFKBIA(1), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), RELA(1), RIPK1(3), SPP1(2), STAT1(1), TBK1(1), TICAM1(2), TIRAP(2), TLR1(1), TLR2(1), TLR3(1), TLR4(8), TLR5(1), TLR7(5), TLR8(3), TLR9(1), TRAF3(1), TRAF6(2)	67859415	341	267	166	40	20	108	32	126	54	1	1.50e-13	<1.00e-15	<8.56e-15
5	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(12), ATF2(2), DLD(1), DUSP10(1), DUSP4(1), GAB1(1), GCK(2), IL1R1(1), JUN(1), MAP2K4(21), MAP2K5(2), MAP2K7(1), MAP3K1(47), MAP3K10(4), MAP3K11(1), MAP3K12(2), MAP3K13(5), MAP3K4(4), MAP3K5(2), MAP3K7(1), MAP3K9(3), MAPK10(1), MAPK8(2), MYEF2(2), NFATC3(3), NR2C2(1), PAPPA(4), SHC1(1), TP53(189), TRAF6(2), ZAK(1)	38087868	321	266	233	21	42	46	38	51	129	15	6.13e-13	<1.00e-15	<8.56e-15
6	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(12), AKT2(1), AKT3(3), BTK(3), FCER1A(2), GAB2(2), GRB2(1), INPP5D(3), KRAS(4), LAT(1), LCP2(1), LYN(4), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K4(21), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), PDK1(1), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLCG1(5), PLCG2(2), PRKCE(1), RAF1(1), SOS1(4), SOS2(2), SYK(2), VAV1(2), VAV2(1), VAV3(1)	55090620	321	257	144	30	20	103	38	120	40	0	<1.00e-15	<1.00e-15	<8.56e-15
7	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(1), BAK1(1), BID(4), CASP2(3), CASP6(2), CASP8(3), FAS(1), FASLG(1), JUN(1), MAP2K4(21), MAP3K1(47), MAPK10(1), MDM2(2), MYC(1), NFKB1(1), NFKBIA(1), PARP1(1), PRF1(2), RELA(1), RIPK1(3), TNFRSF1A(1), TP53(189), TRAF1(1)	27872325	289	249	212	14	39	34	33	47	121	15	5.44e-15	<1.00e-15	<8.56e-15
8	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(3), ELK1(2), FCER1A(2), GRB2(1), JUN(1), LYN(4), MAP2K1(1), MAP2K4(21), MAP2K7(1), MAP3K1(47), MAPK1(1), MAPK3(1), MAPK8(2), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), PAK2(1), PIK3CA(194), PIK3R1(14), PLA2G4A(7), PLCG1(5), PPP3CA(3), PPP3CB(3), RAF1(1), SHC1(1), SOS1(4), SYK(2), VAV1(2)	32114394	333	249	167	20	14	89	32	120	63	15	<1.00e-15	<1.00e-15	<8.56e-15
9	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT1(12), AKT2(1), AKT3(3), ARHGEF11(2), BTK(3), GDI1(4), INPPL1(2), ITPR1(8), ITPR2(3), ITPR3(4), LIMK1(3), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PDK1(1), PIK3CA(194), PIK3CG(2), PIK3R1(14), PITX2(2), PPP1R13B(2), PTEN(17), RHO(2), ROCK1(1), ROCK2(2), RPS4X(1), SAG(1), WASF1(3), WASL(1)	53971164	302	248	128	33	14	97	30	121	39	1	7.40e-13	<1.00e-15	<8.56e-15
10	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(12), AKT2(1), AKT3(3), BAD(1), CDK2(1), CDKN1B(5), CREB1(1), CREB3(1), EBP(1), ERBB4(6), F2RL2(1), GAB1(1), GRB2(1), GSK3A(1), IGF1(1), INPPL1(2), IRS1(1), IRS4(4), MET(5), MYC(1), NOLC1(2), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PARD3(3), PDK1(1), PIK3CA(194), PPP1R13B(2), PREX1(8), PTEN(17), PTK2(3), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SLC2A4(1), SOS1(4), SOS2(2), TSC1(3), TSC2(2), YWHAB(1)	57138393	306	247	132	28	18	98	38	117	34	1	2.78e-15	<1.00e-15	<8.56e-15
11	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	47	AKT1(12), AKT2(1), AKT3(3), CAP1(2), CBL(1), F2RL2(1), GRB2(1), GSK3A(1), INPPL1(2), IRS1(1), IRS4(4), MAPK1(1), MAPK3(1), PARD3(3), PDK1(1), PIK3CA(194), PIK3R1(14), PPYR1(1), PTEN(17), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SLC2A4(1), SORBS1(4), SOS1(4), SOS2(2), YWHAB(1)	43099563	280	244	106	26	14	90	28	113	34	1	2.09e-13	<1.00e-15	<8.56e-15
12	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(12), BCR(1), CRKL(1), GRB2(1), JAK2(5), JUN(1), MAP2K1(1), MAP2K4(21), MAP3K1(47), MAPK3(1), MAPK8(2), MYC(1), PIK3CA(194), PIK3R1(14), RAF1(1), SOS1(4), STAT1(1), STAT5A(3), STAT5B(4)	20923890	315	242	140	12	12	89	17	117	65	15	<1.00e-15	<1.00e-15	<8.56e-15
13	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(12), AKT2(1), AKT3(3), BAD(1), BCR(1), BLNK(1), BTK(3), CD19(2), CD22(2), CR2(2), DAG1(1), GRB2(1), GSK3A(1), INPP5D(3), ITPR1(8), ITPR2(3), ITPR3(4), LYN(4), MAP4K1(3), MAPK1(1), MAPK3(1), NFATC1(1), NFATC2(1), NR0B2(2), PDK1(1), PIK3CA(194), PIK3R1(14), PLCG2(2), PPP1R13B(2), PPP3CA(3), PPP3CB(3), PTPRC(1), RAF1(1), SHC1(1), SOS1(4), SOS2(2), SYK(2), VAV1(2)	55433352	294	242	121	29	15	105	32	117	25	0	2.89e-15	<1.00e-15	<8.56e-15
14	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3E(1), CD3G(1), ELK1(2), GRB2(1), JUN(1), LAT(1), MAP2K1(1), MAP2K4(21), MAP3K1(47), MAPK3(1), MAPK8(2), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NFKB1(1), NFKBIA(1), PIK3CA(194), PIK3R1(14), PLCG1(5), PPP3CA(3), PPP3CB(3), PTPN7(2), RAF1(1), RASA1(2), RELA(1), SHC1(1), SOS1(4), VAV1(2), ZAP70(1)	35946807	323	242	158	21	15	85	26	119	63	15	<1.00e-15	<1.00e-15	<8.56e-15
15	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(12), AKT2(1), AKT3(3), BAD(1), BCR(1), BLNK(1), BTK(3), CD19(2), DAG1(1), EPHB2(2), GRB2(1), ITPKA(1), ITPKB(8), LYN(4), MAP2K1(1), MAP2K2(1), MAPK1(1), NFAT5(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PI3(1), PIK3CA(194), PIK3R1(14), PLCG2(2), PPP1R13B(2), RAF1(1), SERPINA4(3), SHC1(1), SOS1(4), SOS2(2), SYK(2), VAV1(2)	39742716	281	240	108	15	18	96	25	115	26	1	<1.00e-15	<1.00e-15	<8.56e-15
16	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGF(2), EGFR(5), ELK1(2), GRB2(1), JAK1(2), JUN(1), MAP2K1(1), MAP2K4(21), MAP3K1(47), MAPK3(1), MAPK8(2), PIK3CA(194), PIK3R1(14), PLCG1(5), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1), STAT1(1), STAT3(1), STAT5A(3)	28561845	313	237	148	15	14	79	23	118	64	15	<1.00e-15	<1.00e-15	<8.56e-15
17	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(2), CD36(1), CITED2(1), CPT1B(2), CREBBP(2), EHHADH(2), EP300(3), FABP1(1), HSD17B4(4), JUN(1), LPL(1), MAPK1(1), MAPK3(1), MRPL11(1), MYC(1), NCOA1(1), NCOR1(17), NCOR2(3), NFKBIA(1), NR0B2(2), NRIP1(1), PIK3CA(194), PIK3R1(14), PPARA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTGS2(1), RB1(10), RELA(1), SP1(2), STAT5A(3), STAT5B(4)	47935836	282	236	118	21	11	81	25	115	49	1	2.11e-15	<1.00e-15	<8.56e-15
18	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(1), ATM(12), ATR(2), BAI1(7), BID(4), CASP8(3), CCNB1(2), CCNB3(6), CCND1(1), CCND3(3), CCNE1(1), CCNG2(2), CDK2(1), CDK6(1), CHEK2(2), DDB2(1), FAS(1), GTSE1(7), IGF1(1), IGFBP3(1), LRDD(1), MDM2(2), PERP(2), PTEN(17), RCHY1(1), RRM2(1), SERPINE1(2), SESN2(2), SIAH1(3), STEAP3(1), THBS1(4), TP53(189), TP53I3(1), TP73(1), TSC2(2)	49849761	288	234	212	15	45	34	39	60	108	2	4.00e-15	<1.00e-15	<8.56e-15
19	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(12), AKT2(1), AKT3(3), BRAF(3), EIF4B(1), FIGF(2), HIF1A(1), IGF1(1), MAPK1(1), MAPK3(1), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PRKAA1(1), PRKAA2(3), RHEB(1), RICTOR(3), RPS6(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(3), RPS6KB2(4), TSC1(3), TSC2(2), ULK1(2), ULK2(1)	41043171	271	234	98	23	11	96	24	117	23	0	5.11e-15	<1.00e-15	<8.56e-15
20	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(12), CCNB1(2), CCND1(1), CCND3(3), CCNE1(1), CCNG2(2), CDC25A(1), CDK2(1), CDK7(2), CDKN1B(5), CREB3(1), CREB3L1(2), CREB3L3(3), E2F1(2), E2F3(1), E2F4(2), E2F5(1), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), MDM2(2), MNAT1(1), MYC(1), MYT1(2), NACA(3), ORC1L(1), ORC2L(1), ORC3L(1), POLE(5), POLE2(1), RB1(10), RBL1(1), RPA1(1), TFDP1(1), TFDP2(2), TNXB(5), TP53(189), WEE1(1)	55818672	278	232	202	20	43	38	42	50	104	1	2.21e-12	<1.00e-15	<8.56e-15
21	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	ACTA1(1), AGT(3), AKT1(12), CALR(1), CAMK1(2), CAMK1G(1), CREBBP(2), EDN1(2), F2(3), HAND2(2), IGF1(1), LIF(3), MAP2K1(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MEF2C(2), MYH2(2), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NPPA(1), PIK3CA(194), PIK3R1(14), PPP3CA(3), PPP3CB(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RAF1(1)	38119302	271	232	98	24	7	90	33	119	22	0	4.46e-14	<1.00e-15	<8.56e-15
22	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(12), ASAH1(1), BRAF(3), CREB1(1), CREB3(1), CREBBP(2), CRKL(1), DAG1(1), EGR1(1), EGR2(1), EGR3(3), ELK1(2), GNAQ(1), JUN(1), MAP1B(1), MAP2K4(21), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4), NTRK1(3), OPN1LW(1), PIK3C2G(2), PIK3CA(194), PIK3R1(14), PTPN11(1), RPS6KA3(2), SHC1(1), TERF2IP(2)	39579462	286	232	112	18	15	90	25	116	40	0	<1.00e-15	<1.00e-15	<8.56e-15
23	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(12), CREB1(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP3K1(47), MAPK1(1), MAPK14(1), MAPK3(1), NFKB1(1), PIK3CA(194), PIK3R1(14), RB1(10), RELA(1), SP1(2)	15156765	288	231	114	12	6	86	14	116	51	15	<1.00e-15	<1.00e-15	<8.56e-15
24	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), CRKL(1), ELK1(2), GAB1(1), GRB2(1), HGF(3), ITGA1(4), ITGB1(2), JUN(1), MAP2K1(1), MAP2K2(1), MAP4K1(3), MAPK1(1), MAPK3(1), MAPK8(2), MET(5), PAK1(2), PIK3CA(194), PIK3R1(14), PTEN(17), PTK2(3), PTK2B(3), PTPN11(1), PXN(1), RAF1(1), RASA1(2), SOS1(4), STAT3(1)	34979451	273	230	109	16	14	84	24	114	36	1	<1.00e-15	<1.00e-15	<8.56e-15
25	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(12), CDKN1B(5), GRB2(1), ILK(2), ITGB1(2), MAPK1(1), MAPK3(1), PDK2(1), PIK3CA(194), PIK3R1(14), PTEN(17), PTK2(3), SHC1(1), SOS1(4)	14667003	258	226	83	10	7	89	15	111	35	1	<1.00e-15	<1.00e-15	<8.56e-15
26	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(12), EIF4A2(5), EIF4G1(1), EIF4G2(1), EIF4G3(2), GHR(2), IRS1(1), MAPK1(1), MAPK14(1), MAPK3(1), PABPC1(3), PDK2(1), PIK3CA(194), PIK3R1(14), PTEN(17)	21334560	256	225	82	14	7	89	17	109	33	1	<1.00e-15	<1.00e-15	<8.56e-15
27	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CDK5(1), CHN1(2), LIMK1(3), MAP3K1(47), MYLK(6), NCF2(2), PAK1(2), PDGFRA(3), PIK3CA(194), PIK3R1(14), PLD1(1), TRIO(2), VAV1(2), WASF1(3)	26788359	282	225	118	23	7	80	21	117	42	15	9.34e-13	<1.00e-15	<8.56e-15
28	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT1(12), AKT2(1), AKT3(3), BAD(1), BTK(3), GRB2(1), GSK3A(1), IARS(6), INPP5D(3), PDK1(1), PIK3CA(194), PPP1R13B(2), PTEN(17), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SOS1(4), SOS2(2), TEC(1), YWHAB(1)	27296880	259	225	86	13	13	89	22	111	23	1	<1.00e-15	<1.00e-15	<8.56e-15
29	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(12), ATR(2), BRCA1(8), BRCA2(11), CHEK2(2), FANCA(7), FANCC(1), FANCD2(3), FANCE(1), FANCF(1), FANCG(1), MRE11A(1), RAD17(2), RAD50(2), RAD51(1), RAD9A(2), TP53(189)	33653646	246	222	171	10	36	32	34	48	96	0	3.15e-13	<1.00e-15	<8.56e-15
30	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(12), BAD(1), CBL(1), CRKL(1), E2F1(2), GRB2(1), IL2RB(1), IL2RG(1), IRS1(1), JAK1(2), JAK3(2), MAPK1(1), MAPK3(1), MYC(1), PIK3CA(194), PIK3R1(14), RAF1(1), SHC1(1), SOS1(4), STAT5A(3), STAT5B(4), SYK(2)	27280149	251	220	78	19	10	88	15	114	24	0	1.11e-15	<1.00e-15	<8.56e-15
31	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(12), AKT2(1), AKT3(3), BAD(1), GRB2(1), GSK3A(1), IL4R(1), IRS1(1), JAK1(2), JAK3(2), MAP4K1(3), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(194), PIK3R1(14), PPP1R13B(2), RAF1(1), SHC1(1), SOS1(4), SOS2(2), STAT6(1)	26857818	250	220	77	15	9	90	17	111	23	0	<1.00e-15	<1.00e-15	<8.56e-15
32	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(12), CCND1(1), CCNE1(1), CDK2(1), CDK6(1), CDKN1B(5), E2F1(2), MAPK1(1), MAPK3(1), NFKB1(1), NFKBIA(1), PAK1(2), PIK3CA(194), PIK3R1(14), RAF1(1), RB1(10), RELA(1), TFDP1(1)	15552225	250	219	76	8	8	86	13	111	32	0	<1.00e-15	<1.00e-15	<8.56e-15
33	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(3), AKT1(12), CAMK2A(1), CAMK2D(3), CAMK2G(1), CREB1(1), GNAS(5), GRB2(1), MAPK1(1), MAPK14(1), MAPK3(1), PIK3CA(194), PIK3R1(14), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1), RPS6KA5(1), SOS1(4)	21999744	247	218	74	18	10	90	14	113	20	0	9.33e-15	<1.00e-15	<8.56e-15
34	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(12), APC(3), AXIN1(1), CCND1(1), CD14(1), DVL1(2), FZD1(1), GJA1(2), GNAI1(1), IRAK1(1), LBP(1), NFKB1(1), PIK3CA(194), PIK3R1(14), PPP2CA(1), RELA(1), TIRAP(2), TLR4(8)	22933638	247	218	73	19	8	88	13	117	21	0	4.44e-15	<1.00e-15	<8.56e-15
35	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(12), APAF1(1), ATM(12), BAD(1), BID(4), CASP6(2), EIF2S1(1), PTK2(3), PXN(1), STAT1(1), TLN1(9), TP53(189)	21194628	236	217	151	7	33	44	28	44	87	0	<1.00e-15	<1.00e-15	<8.56e-15
36	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP4A(2), INPP4B(4), INPPL1(2), ITPKA(1), ITPKB(8), OCRL(4), PIK3C2A(2), PIK3C2B(4), PIK3C2G(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCG1(5), PLCG2(2)	34320858	251	217	89	17	14	80	25	114	18	0	<1.00e-15	<1.00e-15	<8.56e-15
37	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(12), AKT2(1), AKT3(3), GRB2(1), IARS(6), IL13RA1(1), IL2RG(1), IL4R(1), INPP5D(3), JAK1(2), JAK2(5), JAK3(2), NR0B2(2), PI3(1), PIK3CA(194), PPP1R13B(2), SERPINA4(3), SHC1(1), SOS1(4), SOS2(2), STAT6(1), TYK2(4)	28088814	252	217	79	15	13	87	21	114	17	0	<1.00e-15	<1.00e-15	<8.56e-15
38	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(3), GSN(1), ITGA1(4), ITGB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), MYLK(6), PIK3CA(194), PIK3R1(14), PTK2(3), PXN(1), RAF1(1), ROCK1(1), SHC1(1), TLN1(9)	29134248	243	216	80	16	7	80	20	114	22	0	2.55e-15	<1.00e-15	<8.56e-15
39	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(12), AKT2(1), AKT3(3), BPNT1(1), GRB2(1), ILK(2), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(194), PTEN(17), PTK2B(3), RBL2(1), SHC1(1), SOS1(4)	15395562	243	215	70	9	8	87	15	109	23	1	<1.00e-15	<1.00e-15	<8.56e-15
40	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(21), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PIK3CA(194), PIK3R1(14), TRAF3(1), TRAF6(2)	25717068	252	215	88	15	11	78	16	111	35	1	<1.00e-15	<1.00e-15	<8.56e-15
41	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(3), AKT1(12), BAD(1), CSF2RB(2), IGF1(1), IGF1R(2), IL3RA(1), KIT(5), KITLG(2), PIK3CA(194), PIK3R1(14), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	16610841	240	214	67	11	6	89	17	110	18	0	<1.00e-15	<1.00e-15	<8.56e-15
42	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(3), AKT1(12), ASAH1(1), GNAI1(1), GNB1(1), ITGAV(5), ITGB3(2), MAPK1(1), MAPK3(1), PDGFRA(3), PIK3CA(194), PIK3R1(14), PLCB1(4), PTK2(3), SMPD2(2)	20801703	247	214	74	13	9	91	16	111	20	0	<1.00e-15	<1.00e-15	<8.56e-15
43	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GHR(2), GRB2(1), INSR(2), IRS1(1), JAK2(5), MAP2K1(1), MAPK1(1), MAPK3(1), PIK3CA(194), PIK3R1(14), PLCG1(5), RAF1(1), RPS6KA1(1), SHC1(1), SLC2A4(1), SOS1(4), SRF(1), STAT5A(3), STAT5B(4)	25079769	243	214	80	15	10	79	17	110	27	0	<1.00e-15	<1.00e-15	<8.56e-15
44	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(12), CREB1(1), GRB2(1), MAPK1(1), MAPK3(1), MEF2A(1), MEF2C(2), NTRK1(3), PIK3CA(194), PIK3R1(14), PLCG1(5), RPS6KA1(1), SHC1(1)	15181101	237	213	64	10	9	85	15	107	21	0	<1.00e-15	<1.00e-15	<8.56e-15
45	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), GRB2(1), JAK2(5), JUN(1), MAP2K1(1), MAPK3(1), PIK3CA(194), PIK3R1(14), PLCG1(5), RAF1(1), RASA1(2), SHC1(1), SOS1(4), STAT1(1), STAT3(1), STAT5A(3), STAT5B(4)	22823112	240	213	77	10	10	76	16	109	29	0	<1.00e-15	<1.00e-15	<8.56e-15
46	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(12), BAD(1), GRB2(1), IGF1R(2), IRS1(1), MAP2K1(1), MAPK1(1), MAPK3(1), PIK3CA(194), PIK3R1(14), RAF1(1), SHC1(1), SOS1(4)	14305512	234	212	61	11	5	89	12	109	19	0	<1.00e-15	<1.00e-15	<8.56e-15
47	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S1(1), EIF2S2(1), EIF2S3(1), ELAVL1(2), FLT1(2), FLT4(1), HIF1A(1), KDR(2), NOS3(2), PIK3CA(194), PIK3R1(14), PLCG1(5), PTK2(3), PXN(1), SHC1(1)	26510523	237	212	74	16	9	79	19	110	20	0	4.00e-15	<1.00e-15	<8.56e-15
48	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(4), ATM(12), ATR(2), CCND1(1), CCNE1(1), CDC25A(1), CDK2(1), CDK6(1), CDKN1B(5), E2F1(2), HDAC1(2), RB1(10), TFDP1(1), TGFB3(1), TP53(189)	22504716	233	211	157	9	34	27	29	46	97	0	6.36e-14	<1.00e-15	<8.56e-15
49	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(3), AKT1(12), ATM(12), CPB2(1), FHL2(1), HIF1A(1), IGFBP3(1), MAPK8(2), MDM2(2), NQO1(1), TP53(189)	15096432	225	210	140	14	33	39	30	42	81	0	8.63e-11	<1.00e-15	<8.56e-15
50	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(3), ARHGEF1(5), F2(3), F2R(2), GNAI1(1), GNAQ(1), GNB1(1), MAP3K7(1), PIK3CA(194), PIK3R1(14), PLCB1(4), PTK2B(3), ROCK1(1)	19500234	233	209	70	10	6	78	21	108	20	0	2.22e-15	<1.00e-15	<8.56e-15
51	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(2), HLA-A(6), ITGB1(2), KLRC1(3), KLRC2(1), KLRC3(1), LAT(1), MAP2K1(1), MAPK3(1), PAK1(2), PIK3CA(194), PIK3R1(14), PTK2B(3), SYK(2), VAV1(2)	14429727	235	208	71	13	8	77	19	109	22	0	<1.00e-15	<1.00e-15	<8.56e-15
52	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(12), BAD(1), CHRNB1(2), CHRNG(1), MUSK(3), PIK3CA(194), PIK3R1(14), PTK2(3), PTK2B(3)	12912276	233	207	59	9	5	88	14	109	17	0	<1.00e-15	<1.00e-15	<8.56e-15
53	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	AKT1(12), GNAS(5), GNB1(1), NFKB1(1), NOS3(2), NPPA(1), PIK3CA(194), PIK3R1(14), RELA(1)	13617006	231	207	58	7	5	86	12	109	19	0	<1.00e-15	<1.00e-15	<8.56e-15
54	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(12), CAT(1), GHR(2), IGF1(1), IGF1R(2), PIK3CA(194), PIK3R1(14), SHC1(1), SOD1(1)	9963564	228	207	55	7	4	85	15	107	17	0	<1.00e-15	<1.00e-15	<8.56e-15
55	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(4), ATM(12), BRCA1(8), CHEK2(2), JUN(1), MAPK8(2), MDM2(2), MRE11A(1), NFKB1(1), NFKBIA(1), RAD50(2), RAD51(1), RELA(1), TP53(189), TP73(1)	22260849	228	206	153	7	34	29	29	46	90	0	1.24e-14	<1.00e-15	<8.56e-15
56	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(1), ATM(12), CCND1(1), CCNE1(1), CDK2(1), E2F1(2), MDM2(2), RB1(10), TP53(189)	13917657	219	205	144	6	34	27	25	44	89	0	4.66e-15	<1.00e-15	<8.56e-15
57	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(12), CDC25A(1), CDC25B(3), CDC25C(1), CDK2(1), MYT1(2), RB1(10), TP53(189), WEE1(1)	13623597	220	205	145	6	32	27	28	44	89	0	2.33e-14	<1.00e-15	<8.56e-15
58	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), ELK1(2), GRB2(1), IGF1(1), IGF1R(2), IRS1(1), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PIK3CA(194), PIK3R1(14), PTPN11(1), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1)	18760521	231	204	68	10	7	77	17	108	22	0	<1.00e-15	<1.00e-15	<8.56e-15
59	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), ELK1(2), GRB2(1), JUN(1), KLK2(2), MAP2K1(1), MAPK3(1), MAPK8(2), NGFR(1), PIK3CA(194), PIK3R1(14), PLCG1(5), RAF1(1), SHC1(1), SOS1(4)	14332890	231	204	68	8	8	77	14	109	23	0	<1.00e-15	<1.00e-15	<8.56e-15
60	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), ELK1(2), GRB2(1), INSR(2), IRS1(1), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PIK3CA(194), PIK3R1(14), PTPN11(1), RAF1(1), RASA1(2), SHC1(1), SLC2A4(1), SOS1(4), SRF(1)	19372977	231	203	68	11	7	77	16	109	22	0	<1.00e-15	<1.00e-15	<8.56e-15
61	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(12), AKT2(1), AKT3(3), ELK1(2), GRB2(1), MAP2K1(1), MAP2K2(1), NGFR(1), NTRK1(3), PIK3CA(194), SHC1(1), SOS1(4)	12494508	224	202	52	9	8	84	13	107	12	0	<1.00e-15	<1.00e-15	<8.56e-15
62	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(2), EP300(3), IL2RG(1), IL7R(1), JAK1(2), JAK3(2), PIK3CA(194), PIK3R1(14), PTK2B(3), STAT5A(3), STAT5B(4)	21495279	229	201	65	11	7	74	15	109	24	0	1.33e-15	<1.00e-15	<8.56e-15
63	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD3E(1), CD3G(1), CD86(2), CTLA4(1), GRB2(1), HLA-DRB1(4), ICOS(1), IL2(1), ITK(4), PIK3CA(194), PIK3R1(14), PTPN11(1)	9251736	225	200	62	10	5	76	16	110	18	0	<1.00e-15	<1.00e-15	<8.56e-15
64	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(2), PAX3(2), RARA(1), RB1(10), SIRT1(1), SP100(4), TNFRSF1A(1), TP53(189)	13908024	210	199	135	7	31	26	26	42	85	0	1.55e-14	<1.00e-15	<8.56e-15
65	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(2), IKBKB(3), JAK2(5), NFKB1(1), NFKBIA(1), RB1(10), RELA(1), TNFRSF1A(1), TP53(189), USH1C(1), WT1(1)	13418262	215	198	140	6	32	26	26	43	88	0	<1.00e-15	<1.00e-15	<8.56e-15
66	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1A(1), ARPC1B(1), ARPC2(2), PAK1(2), PDGFRA(3), PIK3CA(194), PIK3R1(14), WASL(1)	10289565	218	196	55	12	5	75	14	106	18	0	1.30e-14	<1.00e-15	<8.56e-15
67	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), CCND1(1), CDK2(1), CDKN1B(5), E2F1(2), MDM2(2), PRB1(1), TP53(189)	6197568	202	195	126	4	33	24	24	40	81	0	<1.00e-15	<1.00e-15	<8.56e-15
68	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(2), MAX(2), MYC(1), SP1(2), SP3(3), TP53(189), WT1(1)	5154162	200	191	125	6	30	25	24	43	78	0	6.77e-15	<1.00e-15	<8.56e-15
69	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	DNAJC3(2), EIF2S1(1), EIF2S2(1), NFKB1(1), NFKBIA(1), RELA(1), TP53(189)	7773831	196	188	121	3	31	25	25	39	76	0	<1.00e-15	<1.00e-15	<8.56e-15
70	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP6(2), CASP8(3), DFFB(2), JUN(1), LMNB1(1), MAP2K4(21), MAP3K1(47), MAP3K7(1), MAPK8(2), PAK1(2), PAK2(1), PRKDC(8), PTPN13(4), RB1(10), SPTAN1(2)	32747130	108	93	106	9	6	13	11	12	51	15	0.0055	<1.00e-15	<8.56e-15
71	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAD(1), CASP8(3), MAP2K1(1), MAP2K4(21), MAP3K1(47), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(1), NSMAF(3), RAF1(1), RELA(1), RIPK1(3), TNFRSF1A(1)	15271347	87	77	84	7	6	8	6	10	42	15	0.0084	<1.00e-15	<8.56e-15
72	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(3), IKBKB(3), JUN(1), LTA(1), MAP2K3(1), MAP2K4(21), MAP3K1(47), MAPK14(1), MAPK8(2), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(3), TANK(1), TNFRSF1A(1)	18122715	88	77	86	6	6	7	11	7	42	15	0.0042	<1.00e-15	<8.56e-15
73	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(12), PIK3CA(194), PIK3R1(14), PLCB1(4), PLCG1(5), VAV1(2)	9887514	231	212	58	7	7	85	12	107	20	0	1.89e-15	1.33e-15	1.12e-14
74	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	AKT1(12), AKT2(1), AKT3(3), BLNK(1), BTK(3), CARD11(3), CD19(2), CD22(2), CD79A(1), CD79B(1), CR2(2), IFITM1(1), IKBKB(3), INPP5D(3), JUN(1), KRAS(4), LYN(4), MALT1(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLCG2(2), PPP3CA(3), PPP3CB(3), SYK(2), VAV1(2), VAV2(1), VAV3(1)	56823546	295	244	121	35	12	99	38	117	28	1	1.27e-11	1.44e-15	1.19e-14
75	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	AKT1(12), DAG1(1), DGKA(3), ITGA9(2), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), MAP2K1(1), MAPK1(1), MAPK3(1), NR1I3(1), PAK1(2), PDE3A(7), PDE3B(1), PI3(1), PIK3C2G(2), PIK3CA(194), PIK3R1(14), RIPK3(1), RPS4X(1), SGCB(1)	38066574	270	231	97	27	9	100	19	117	25	0	5.96e-14	1.44e-15	1.19e-14
76	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(12), BAD(1), GHR(2), NFKB1(1), NFKBIA(1), PIK3CA(194), PIK3R1(14), PPP2CA(1), RELA(1)	10832055	227	206	54	6	4	87	11	107	18	0	<1.00e-15	1.55e-15	1.26e-14
77	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(12), EGFR(5), IGF1R(2), MYC(1), POLR2A(2), PPP2CA(1), RB1(10), TEP1(9), TP53(189)	21449142	231	209	146	10	31	39	29	48	84	0	1.55e-15	1.67e-15	1.33e-14
78	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(1), INPP4A(2), INPP4B(4), INPP5B(4), INPPL1(2), IPMK(1), ITGB1BP3(1), ITPK1(1), ITPKA(1), ITPKB(8), MINPP1(1), OCRL(4), PI4KA(4), PI4KB(1), PIK3C3(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIP4K2A(1), PIP4K2C(5), PIP5K1A(1), PIP5K1C(4), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCD3(3), PLCE1(7), PLCG1(5), PLCG2(2), PLCZ1(3), PTEN(17), SYNJ2(1)	56986800	300	253	137	32	19	82	40	121	37	1	2.80e-12	1.78e-15	1.40e-14
79	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	ALG2(2), BAK1(1), BFAR(1), BTK(3), CAD(7), CASP8(3), EGFR(5), EPHB2(2), IL1A(1), MAP2K4(21), MAP2K7(1), MAP3K1(47), MAP3K5(2), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4), MET(5), NFAT5(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), NR0B2(2), PTPN13(4), RIPK1(3), ROCK1(1), TP53(189), TUFM(2)	55873428	322	258	245	22	42	41	43	53	127	16	4.17e-13	1.89e-15	1.47e-14
80	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), ELK1(2), GRB2(1), JAK1(2), JUN(1), MAP2K1(1), MAP2K4(21), MAP3K1(47), MAPK3(1), MAPK8(2), PDGFRA(3), PIK3CA(194), PIK3R1(14), PLCG1(5), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1), STAT1(1), STAT3(1), STAT5A(3)	26694057	309	234	144	13	14	79	22	115	64	15	<1.00e-15	2.00e-15	1.54e-14
81	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT1(12), AKT2(1), AKT3(3), BCR(1), BTK(3), CD19(2), GAB1(1), ITPR1(8), ITPR2(3), ITPR3(4), LYN(4), NR0B2(2), PDK1(1), PIK3CA(194), PITX2(2), PLCG2(2), PPP1R13B(2), PREX1(8), PTEN(17), PTPRC(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SAG(1), SYK(2), TEC(1), VAV1(2)	41993796	282	235	109	18	18	93	29	115	26	1	<1.00e-15	2.11e-15	1.60e-14
82	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(12), CABIN1(5), CAMK1(2), CAMK1G(1), HDAC5(2), IGF1(1), IGF1R(2), INSR(2), MAPK14(1), MEF2A(1), MEF2C(2), NFATC1(1), NFATC2(1), PIK3CA(194), PIK3R1(14), PPP3CA(3), PPP3CB(3)	26131794	247	216	74	20	4	92	17	113	21	0	3.44e-15	2.22e-15	1.67e-14
83	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(12), ATR(2), BRCA1(8), CCNB1(2), CDC25A(1), CDC25B(3), CDC25C(1), CHEK2(2), EP300(3), MDM2(2), MYT1(2), PRKDC(8), RPS6KA1(1), TP53(189), WEE1(1)	33087327	237	211	161	12	37	31	34	47	88	0	6.80e-13	2.33e-15	1.73e-14
84	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(12), EIF4A2(5), EIF4B(1), EIF4G1(1), EIF4G2(1), EIF4G3(2), PDK2(1), PIK3CA(194), PIK3R1(14), PPP2CA(1), PTEN(17), RPS6(2), TSC1(3), TSC2(2)	21380697	256	224	82	11	7	89	17	111	31	1	<1.00e-15	2.66e-15	1.95e-14
85	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	GNAI1(1), GNAQ(1), GNB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), NFKB1(1), PIK3C2G(2), PIK3CA(194), PIK3R1(14), PLCG1(5), PTK2(3), PTK2B(3), PXN(1), RAF1(1), RELA(1)	21474999	231	206	68	9	5	80	16	110	20	0	<1.00e-15	2.78e-15	1.99e-14
86	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(12), ATR(2), CDC25C(1), CHEK2(2), TP53(189)	12093471	206	197	131	6	32	26	25	43	80	0	7.65e-12	2.78e-15	1.99e-14
87	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(12), EIF2B5(1), EIF2S1(1), EIF2S2(1), EIF2S3(1), IGF1(1), IGF1R(2), INPPL1(2), PDK2(1), PIK3CA(194), PIK3R1(14), PPP2CA(1), PTEN(17), RPS6(2)	14995539	250	223	76	13	6	87	18	109	29	1	<1.00e-15	3.00e-15	2.10e-14
88	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(12), BAD(1), ELK1(2), MAP2K1(1), MAPK3(1), NFKB1(1), PIK3CA(194), PIK3R1(14), RAF1(1), RELA(1), RHOA(2)	15063984	230	209	57	11	6	86	12	108	18	0	<1.00e-15	3.00e-15	2.10e-14
89	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(4), ABL2(2), AKT1(12), AKT2(1), AKT3(3), ARAF(1), BAD(1), BRAF(3), BTC(2), CAMK2A(1), CAMK2D(3), CAMK2G(1), CBL(1), CBLB(9), CBLC(3), CDKN1B(5), CRKL(1), EGF(2), EGFR(5), ELK1(2), ERBB2(8), ERBB3(9), ERBB4(6), GAB1(1), GRB2(1), JUN(1), KRAS(4), MAP2K1(1), MAP2K2(1), MAP2K4(21), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MYC(1), NCK1(1), NCK2(1), NRG1(1), NRG3(2), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLCG1(5), PLCG2(2), PRKCG(2), PTK2(3), RAF1(1), RPS6KB2(4), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(2), STAT5A(3), STAT5B(4), TGFA(1)	77961897	385	276	207	46	27	110	54	138	56	0	4.80e-13	3.33e-15	2.28e-14
90	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(56), MAP2K3(1), MAPK14(1), NFATC1(1), NFATC2(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	8406567	63	61	41	9	0	1	5	5	51	1	0.98	3.33e-15	2.28e-14
91	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(12), APC(3), AR(4), ASAH1(1), BRAF(3), CCL13(1), DAG1(1), EGFR(5), GNAI1(1), GNAQ(1), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), KCNJ3(1), MAPK1(1), MAPK10(1), MAPK14(1), PHKA2(4), PIK3CA(194), PIK3R1(14), PITX2(2), PTX3(1), RAF1(1)	41237352	276	238	103	26	10	94	23	122	27	0	2.70e-14	3.44e-15	2.33e-14
92	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(12), GRB2(1), KLK2(2), NTRK1(3), PIK3CA(194), PIK3R1(14), PLCG1(5), SHC1(1), SOS1(4)	11900811	236	213	63	8	6	87	14	109	20	0	<1.00e-15	3.77e-15	2.53e-14
93	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(1), BAD(1), BAK1(1), BCL2L11(2), BID(4), CASP1(1), CASP2(3), CASP6(2), CASP8(3), DFFB(2), FAS(1), FASLG(1), IKBKB(3), IRF1(1), IRF3(2), IRF6(2), JUN(1), LTA(1), MAP2K4(21), MAP3K1(47), MAPK10(1), MDM2(2), MYC(1), NFKB1(1), NFKBIA(1), NFKBIE(1), PLEKHG5(3), PRF1(2), RELA(1), RIPK1(3), TNFRSF1A(1), TNFRSF21(2), TP53(189), TP73(1), TRAF1(1), TRAF3(1)	42863301	311	261	234	17	42	42	38	51	123	15	2.89e-15	4.22e-15	2.79e-14
94	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	IKBKAP(3), IKBKB(3), MAP3K1(47), NFKB1(1), NFKBIA(1), RELA(1), TNFAIP3(1), TRAF3(1), TRAF6(2)	14219322	60	51	59	7	1	5	6	6	27	15	0.25	5.07e-14	3.32e-13
95	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), IKBKB(3), IL2(1), JUN(1), MAP3K1(47), MAP3K5(2), MAPK14(1), MAPK8(2), NFKB1(1), NFKBIA(1), RELA(1)	15187692	62	52	61	7	2	3	8	6	28	15	0.27	9.47e-14	6.14e-13
96	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(2), EGFR(5), MAP2K1(1), MAP3K1(47), MAPK14(1), NCOR2(3), RARA(1), THRA(1), THRB(1)	13511043	62	53	61	9	1	3	8	8	27	15	0.49	1.67e-13	1.07e-12
97	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(12), AKT2(1), AKT3(3), BAD(1), KDR(2), KRAS(4), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPKAPK3(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NOS3(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLCG1(5), PLCG2(2), PPP3CA(3), PPP3CB(3), PRKCG(2), PTGS2(1), PTK2(3), PXN(1), RAF1(1), SH2D2A(2), SHC2(1), SPHK2(2)	55078959	300	246	124	41	13	102	36	122	27	0	2.42e-10	7.77e-13	4.93e-12
98	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	IKBKAP(3), IKBKB(3), LTA(1), MAP3K1(47), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(3), TANK(1), TNFAIP3(1), TRAF1(1), TRAF3(1)	17274504	64	55	63	8	1	6	9	5	28	15	0.19	2.33e-11	1.46e-10
99	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(1), BAG4(1), CASP2(3), CASP8(3), DFFB(2), JUN(1), LMNB1(1), MADD(8), MAP2K4(21), MAP3K1(47), MAP3K7(1), MAPK8(2), PAK1(2), PAK2(1), PRKDC(8), RB1(10), RIPK1(3), SPTAN1(2), TNFRSF1A(1)	29899311	118	99	116	11	7	15	14	14	53	15	0.0045	3.91e-11	2.43e-10
100	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(4), ANAPC1(2), ANAPC4(1), ANAPC5(5), ANAPC7(2), ATM(12), ATR(2), BUB1(1), CCNA2(2), CCNB1(2), CCNB3(6), CCND1(1), CCND3(3), CCNE1(1), CDC23(1), CDC25A(1), CDC25B(3), CDC25C(1), CDC27(1), CDC7(1), CDK2(1), CDK6(1), CDK7(2), CDKN1B(5), CHEK2(2), CREBBP(2), CUL1(1), E2F1(2), E2F3(1), EP300(3), ESPL1(7), HDAC1(2), HDAC2(3), MAD2L1(2), MAD2L2(1), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), MDM2(2), ORC1L(1), ORC2L(1), ORC3L(1), PLK1(2), PRKDC(8), PTTG2(1), RB1(10), RBL1(1), RBL2(1), SMAD2(3), SMAD3(2), SMAD4(1), SMC1A(4), SMC1B(2), TFDP1(1), TGFB3(1), TP53(189), WEE1(1), YWHAB(1)	104866866	328	249	251	31	49	42	56	65	115	1	2.26e-10	8.76e-09	5.40e-08
101	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CD14(1), ELK1(2), IKBKB(3), IRAK1(1), JUN(1), MAP2K3(1), MAP2K4(21), MAP3K1(47), MAP3K7(1), MAPK14(1), MAPK8(2), NFKB1(1), NFKBIA(1), PPARA(1), RELA(1), TIRAP(2), TLR10(1), TLR2(1), TLR3(1), TLR4(8), TLR7(5), TLR9(1), TRAF6(2)	28110108	106	88	103	12	11	10	11	11	48	15	0.015	5.80e-08	3.54e-07
102	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	CRKL(1), GNAQ(1), GRB2(1), JUN(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K4(21), MAP3K1(47), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), PAK1(2), PLCG1(5), PTK2B(3), RAF1(1), SHC1(1), SOS1(4)	21717852	96	84	94	13	8	9	12	9	43	15	0.079	7.07e-08	4.27e-07
103	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(4), AKT1(12), AKT2(1), AKT3(3), ARHGEF6(1), ARHGEF7(2), BRAF(3), CAV1(1), CSE1L(2), EPHB2(2), GRB2(1), GRB7(3), GRLF1(5), ILK(2), ITGA1(4), ITGA10(2), ITGA11(5), ITGA2(3), ITGA4(1), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGA9(2), ITGB3BP(1), MAP2K4(21), MAP2K7(1), MAP3K11(1), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4), MYLK(6), MYLK2(1), P4HB(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PIK3CA(194), PIK3CB(4), PKLR(1), PLCG1(5), PLCG2(2), PTEN(17), PTK2(3), RAF1(1), RHO(2), ROCK1(1), ROCK2(2), SHC1(1), SOS1(4), SOS2(2), TERF2IP(2), TLN1(9), TLN2(5), WAS(2)	93436551	377	280	203	52	34	107	43	133	59	1	2.05e-11	1.76e-07	1.05e-06
104	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(12), AKT2(1), AKT3(3), ARHGEF11(2), LPA(7), MAP2K4(21), MAP3K1(47), MAP3K5(2), MAPK8(2), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PDK1(1), PHKA2(4), PI3(1), PIK3CB(4), PLD1(1), PLD3(2), PTK2(3), RDX(1), ROCK1(1), ROCK2(2), SERPINA4(3), SRF(1)	37415079	127	105	115	13	15	22	17	9	48	16	0.00068	3.75e-07	2.22e-06
105	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(12), AKT2(1), AKT3(3), CBL(1), CBLB(9), CBLC(3), CCND1(1), CCND3(3), CNTFR(1), CREBBP(2), CSF2RA(2), CSF2RB(2), CSF3R(2), EP300(3), EPOR(2), GH2(2), GHR(2), GRB2(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNK(1), IL10RA(1), IL10RB(3), IL11RA(2), IL12A(1), IL12B(1), IL12RB1(3), IL13RA1(1), IL13RA2(3), IL15(1), IL2(1), IL21(1), IL21R(1), IL22(1), IL22RA1(1), IL22RA2(1), IL23R(3), IL28A(1), IL28B(3), IL28RA(1), IL2RB(1), IL2RG(1), IL3RA(1), IL4R(1), IL5RA(1), IL6(2), IL6R(1), IL6ST(3), IL7R(1), IRF9(3), JAK1(2), JAK2(5), JAK3(2), LEPR(3), LIF(3), LIFR(4), MYC(1), OSMR(4), PIAS2(3), PIAS4(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PRLR(1), PTPN11(1), SOCS4(1), SOCS5(1), SOS1(4), SOS2(2), SPRED1(3), SPRED2(1), SPRY3(1), STAM(2), STAM2(1), STAT1(1), STAT2(2), STAT3(1), STAT4(5), STAT5A(3), STAT5B(4), STAT6(1), TPO(6), TSLP(1), TYK2(4)	110778486	401	285	226	51	31	119	58	138	54	1	6.49e-14	6.06e-07	3.56e-06
106	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	AKT1(12), AKT2(1), AKT3(3), CARD11(3), CBL(1), CBLB(9), CBLC(3), CD3E(1), CD3G(1), CD4(2), CD40LG(1), CD8A(1), CTLA4(1), GRAP2(1), GRB2(1), ICOS(1), IKBKB(3), IL2(1), ITK(4), JUN(1), KRAS(4), LAT(1), LCP2(1), MALT1(1), MAP3K8(2), NCK1(1), NCK2(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PDCD1(1), PDK1(1), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLCG1(5), PPP3CA(3), PPP3CB(3), PRKCQ(3), PTPRC(1), RHOA(2), SOS1(4), SOS2(2), TEC(1), VAV1(2), VAV2(1), VAV3(1), ZAP70(1)	76554972	333	260	159	46	17	108	49	128	30	1	2.41e-10	9.27e-07	5.39e-06
107	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(3), ATF2(2), EGFR(5), ELK1(2), GNAQ(1), GRB2(1), JUN(1), MAP2K1(1), MAP2K2(1), MAP2K4(21), MAP3K1(47), MAPK1(1), MAPK3(1), MAPK8(2), MEF2A(1), MEF2C(2), PAK1(2), PTK2(3), PTK2B(3), RAF1(1), SHC1(1), SOS1(4)	26257023	106	89	104	15	9	10	17	12	43	15	0.070	2.55e-06	0.000015
108	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(3), CDH1(33), CREBBP(2), EP300(3), MAP2K1(1), MAP3K7(1), MAPK3(1), SKIL(2), TGFB3(1), TGFBR1(2), TGFBR2(3)	19726863	52	49	48	9	2	9	4	4	33	0	0.34	5.41e-06	0.000031
109	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CDK2(1), CDKN1B(5), CUL1(1), E2F1(2), NEDD8(1), RB1(10), TFDP1(1)	6656403	22	21	21	1	3	0	2	3	14	0	0.10	0.000066	0.00038
110	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(2), BCR(1), BLNK(1), ELK1(2), GRB2(1), JUN(1), LYN(4), MAP2K1(1), MAP3K1(47), MAPK1(1), MAPK3(1), MAPK8IP3(4), PAPPA(4), RPS6KA1(1), RPS6KA3(2), SHC1(1), SOS1(4), SYK(2), VAV1(2), VAV2(1), VAV3(1)	24506352	84	72	83	10	10	8	14	10	27	15	0.027	0.000099	0.00055
111	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(1), ACVR1B(5), AKT1(12), BMPR2(2), BUB1(1), CDKL1(2), CDKL2(1), CDS1(2), CDS2(1), CLK1(1), CLK4(1), COL4A3BP(1), CSNK2A1(1), CSNK2A2(1), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), IMPA1(1), INPP4A(2), INPP4B(4), INPPL1(2), ITPKA(1), ITPKB(8), MAP3K10(4), MOS(2), NEK1(1), NEK3(2), OCRL(4), PIK3C2A(2), PIK3C2B(4), PIK3C2G(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIM2(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCG1(5), PLCG2(2), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(3), PRKCZ(1), PRKD1(2), PRKG1(1), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), TGFBR1(2)	87942192	332	263	158	46	29	96	48	128	31	0	8.10e-11	0.00012	0.00067
112	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CDS1(2), CDS2(1), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), DGKI(6), IMPA1(1), INPP4A(2), INPP4B(4), INPP5B(4), INPP5D(3), INPPL1(2), ITGB1BP3(1), ITPK1(1), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), OCRL(4), PI4KA(4), PI4KB(1), PIK3C2A(2), PIK3C2B(4), PIK3C2G(2), PIK3C3(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PIP4K2A(1), PIP4K2C(5), PIP5K1A(1), PIP5K1C(4), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCD3(3), PLCE1(7), PLCG1(5), PLCG2(2), PLCZ1(3), PRKCG(2), PTEN(17), SYNJ2(1)	97330818	364	290	199	57	28	97	52	132	54	1	1.87e-08	0.00072	0.0040
113	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(2), CREB1(1), ELK1(2), GRB2(1), MAP2K4(21), MAP3K1(47), MAP3K5(2), MAP3K7(1), MAP3K9(3), MAPK14(1), MAX(2), MEF2A(1), MEF2C(2), MYC(1), PLA2G4A(7), RIPK1(3), RPS6KA5(1), SHC1(1), STAT1(1), TGFB3(1), TGFBR1(2)	28236858	103	85	100	14	6	12	18	8	44	15	0.094	0.0011	0.0058
114	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYB(1), NFYC(1), RB1(10), SP1(2), SP3(3)	5101941	17	16	17	2	0	1	0	5	11	0	0.39	0.0019	0.010
115	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDK2(1), CUL1(1), E2F1(2), FBXW7(2), RB1(10), TFDP1(1)	6552975	18	17	18	1	4	0	1	4	9	0	0.098	0.0035	0.019
116	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IKBKB(3), IL1A(1), IL1R1(1), IRAK1(1), MAP3K1(47), MAP3K7(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(3), TLR4(8), TNFAIP3(1), TNFRSF1A(1), TRAF6(2)	18057312	72	58	70	11	4	6	9	9	29	15	0.31	0.0060	0.032
117	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), LPO(5), MPO(2), PRDX1(1), PRDX5(1), TPO(6), TYR(4)	7428057	20	20	20	2	6	2	5	3	4	0	0.067	0.014	0.073
118	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNB1(2), CCND1(1), CCND3(3), CCNE1(1), CDC25A(1), CDK2(1), CDK6(1), CDK7(2), CDKN1B(5), E2F1(2), RB1(10), RBL1(1), TFDP1(1)	11870391	31	29	30	4	3	1	5	6	15	1	0.29	0.014	0.075
119	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	7	CCL11(1), CCR3(1), HLA-DRB1(4)	1828749	6	6	6	1	0	1	1	2	2	0	0.43	0.015	0.077
120	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(3), CREM(2), FHL5(1), FSHR(4), GNAS(5), XPO1(3)	6833346	18	18	18	2	4	4	3	5	2	0	0.13	0.015	0.077
121	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNE1(1), CDK2(1), CUL1(1), E2F1(2), RB1(10), TFDP1(1)	6725862	16	15	16	1	3	0	1	3	9	0	0.15	0.018	0.094
122	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(8)	4432701	12	12	12	0	2	1	3	4	2	0	0.040	0.024	0.12
123	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(4), B3GALT1(1), B3GALT2(1), B3GALT5(1), FUT2(2), FUT3(4), ST3GAL3(1), ST3GAL4(1)	5407662	15	15	14	2	4	5	2	2	2	0	0.050	0.028	0.14
124	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNA1(1), IFNB1(1), IKBKB(3), IL1A(1), IL1R1(1), IL1RAP(2), IL1RN(2), IL6(2), IRAK1(1), IRAK2(3), IRAK3(1), JUN(1), MAP2K3(1), MAP3K1(47), MAP3K7(1), MAPK14(1), MAPK8(2), NFKB1(1), NFKBIA(1), RELA(1), TGFB3(1), TRAF6(2)	22780524	77	63	76	12	6	8	9	9	30	15	0.25	0.034	0.17
125	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(4), FUT2(2), FUT3(4), FUT5(1), ST3GAL3(1)	3810105	12	12	11	2	4	3	1	2	2	0	0.096	0.039	0.19
126	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(3), CD79A(1), CD79B(1), ELK1(2), GRB2(1), JUN(1), LYN(4), MAP2K1(1), MAP3K1(47), MAPK14(1), MAPK3(1), MAPK8(2), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), PLCG1(5), PPP3CA(3), PPP3CB(3), RAF1(1), SHC1(1), SOS1(4), SYK(2), VAV1(2)	28636881	96	83	95	16	8	12	16	13	32	15	0.13	0.050	0.24
127	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(3), ASAH1(1), CERK(1), CREB1(1), CREB3(1), DAG1(1), EPHB2(2), GNAQ(1), ITPKA(1), ITPKB(8), JUN(1), MAP2K4(21), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4)	21423792	54	52	53	8	9	6	9	10	20	0	0.059	0.057	0.28
128	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	EGR2(1), EGR3(3), GNAQ(1), MAP3K1(47), MYC(1), NFATC1(1), NFATC2(1), NFKB1(1), NFKBIA(1), PLCG1(5), PPP3CA(3), PPP3CB(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RELA(1), VIP(1)	20556822	73	64	72	14	3	5	8	11	31	15	0.57	0.066	0.32
129	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(4), ALDOB(2), TPI1(2)	2928939	8	8	8	0	0	4	3	0	1	0	0.051	0.071	0.34
130	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), LPO(5), MPO(2), TPO(6)	6402396	14	14	14	0	6	1	2	2	3	0	0.012	0.074	0.35
131	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	ACTG1(1), APAF1(1), ARHGDIB(1), BAG4(1), BID(4), CASP2(3), CASP6(2), CASP8(3), DFFB(2), GSN(1), LMNB1(1), MAP2K7(1), MAP3K1(47), MAP3K5(2), MAPK8(2), MDM2(2), NFKB1(1), NFKBIA(1), NUMA1(3), PAK2(1), PRKDC(8), PSEN1(1), PSEN2(3), PTK2(3), RASA1(2), RB1(10), RELA(1), RIPK1(3), SPTAN1(2), TNFRSF1A(1), TRAF1(1)	53316627	115	95	114	12	10	16	15	15	44	15	0.0041	0.076	0.36
132	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA2(2), CCND1(1), CCNE1(1), CDK2(1), CDKN1B(5), E2F1(2), E2F4(2), PRB1(1)	6746142	15	15	14	2	4	1	0	2	8	0	0.32	0.080	0.37
133	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(2), CBS(2), CTH(3), MUT(1)	3739125	8	8	8	0	1	1	1	1	4	0	0.14	0.11	0.49
134	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(2), ALOX5(1), CBR1(1), CBR3(1), CYP4F2(1), EPX(1), GGT1(2), LPO(5), MPO(2), PLA2G2E(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PRDX1(1), PRDX5(1), PTGDS(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(1), TPO(6)	21581976	43	41	41	3	9	5	14	7	8	0	0.00095	0.12	0.55
135	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(1), KHK(1), LCT(6), PGM1(2), PYGL(1), PYGM(4), TPI1(2), TREH(1)	10340265	18	18	18	1	3	1	3	5	6	0	0.043	0.12	0.56
136	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(1), EPX(1), LPO(5), MPO(2), PRDX1(1), PRDX5(1), TPO(6)	9083412	17	17	17	1	7	1	2	3	4	0	0.036	0.14	0.64
137	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(2), ESR2(2), ITPKA(1), PDE1A(2), PDE1B(2), PLCB1(4), PLCB2(2), VIP(1)	8374626	16	16	16	2	2	6	3	3	2	0	0.11	0.15	0.67
138	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNAQ(1), GNB1(1), HTR2C(1), PLCB1(4), TUB(2)	5413746	11	11	11	1	3	1	5	1	1	0	0.20	0.16	0.70
139	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(1), CD3E(1), CD3G(1), CD4(2), CD8A(1), IL6(2), KITLG(2)	4752618	12	12	12	3	0	3	4	2	3	0	0.47	0.17	0.75
140	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(1)	4319640	9	9	9	1	1	3	2	2	1	0	0.18	0.19	0.83
141	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1), CD3G(1)	894855	2	2	2	0	0	1	0	1	0	0	0.51	0.20	0.87
142	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IL12A(1), IL12B(1), IL2(1)	2357043	4	4	4	1	0	0	0	3	1	0	0.82	0.21	0.90
143	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CDO1(1), GAD1(2), GAD2(3), GGT1(2)	4423575	9	9	9	0	2	2	3	1	1	0	0.045	0.23	1.00
144	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(1), BID(4), BRAF(3), CD244(1), FAS(1), FASLG(1), GRB2(1), HLA-A(6), HLA-C(3), HLA-E(2), HLA-G(2), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), IFNAR1(1), IFNAR2(1), IFNB1(1), ITGAL(1), ITGB2(3), KIR2DL1(2), KIR2DL3(2), KIR2DL4(1), KIR3DL2(4), KLRC1(3), KLRC2(1), KLRC3(1), KLRK1(2), KRAS(4), LAT(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MICA(1), NCR1(1), NCR2(2), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), PAK1(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLCG1(5), PLCG2(2), PPP3CA(3), PPP3CB(3), PRF1(2), PRKCG(2), PTK2B(3), PTPN11(1), RAF1(1), SH3BP2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(2), SYK(2), TNFRSF10D(1), ULBP1(1), ULBP3(2), VAV1(2), VAV2(1), VAV3(1), ZAP70(1)	85272837	346	261	181	58	20	105	55	126	40	0	9.95e-08	0.26	1.00
145	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(1), EPX(1), LPO(5), MPO(2), TPO(6)	8813181	15	15	15	1	7	1	2	2	3	0	0.049	0.27	1.00
146	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), CD38(2), ENPP1(4), ENPP3(2), NMNAT1(1), NMNAT2(1), NNT(4), NT5E(3)	11018631	20	20	20	3	0	1	13	4	2	0	0.33	0.27	1.00
147	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	549588	1	1	1	1	0	0	0	0	1	0	0.92	0.29	1.00
148	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(3)	1313637	3	3	3	1	2	0	0	0	1	0	0.79	0.29	1.00
149	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(2)	1214772	2	2	2	0	0	0	1	0	1	0	0.55	0.32	1.00
150	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), HSD17B1(1), HSD17B2(1), HSD17B4(4), HSD3B2(3)	6183372	10	10	10	1	2	1	5	1	1	0	0.29	0.32	1.00
151	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(1), CYP11B2(3), CYP17A1(1), HSD11B1(2), HSD3B2(3)	5225142	11	11	11	2	1	0	7	3	0	0	0.40	0.35	1.00
152	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(1), PCYT1A(1), PDHA1(2), PDHA2(2), SLC18A3(2)	5192187	10	10	10	1	2	4	4	0	0	0	0.085	0.35	1.00
153	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1), RAB1A(1), RAB3A(1), RAB6A(1)	3309189	5	5	5	0	0	0	2	0	3	0	0.39	0.36	1.00
154	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(3), CPS1(5), GLS(1)	5934435	11	11	11	2	1	2	4	3	1	0	0.36	0.37	1.00
155	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(1)	1678677	3	3	3	1	1	0	0	2	0	0	0.75	0.38	1.00
156	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(12), CDC25A(1), CDC25B(3), CDC25C(1), MYT1(2), WEE1(1)	10634325	20	19	20	3	3	4	5	3	5	0	0.16	0.40	1.00
157	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3	CD4(2), HLA-DRB1(4)	1323270	6	6	6	3	0	1	2	2	1	0	0.73	0.41	1.00
158	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(4), FBL(2), LDHC(1), MAPK14(1), NCL(2)	6997107	10	10	10	1	3	3	2	1	1	0	0.14	0.42	1.00
159	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(3), HLCS(1)	2421432	4	4	4	0	1	0	3	0	0	0	0.32	0.46	1.00
160	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22(1), IL22RA1(1), IL22RA2(1), JAK1(2), JAK2(5), JAK3(2), STAT1(1), STAT3(1), STAT5A(3), STAT5B(4), TYK2(4)	14153919	26	25	25	4	7	0	7	4	8	0	0.14	0.46	1.00
161	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(3), IL4R(1), JAK1(2), JAK2(5), TYK2(4)	8002995	16	15	15	3	1	1	6	5	3	0	0.43	0.46	1.00
162	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(3), IL4R(1), JAK1(2), JAK2(5), TYK2(4)	8002995	16	15	15	3	1	1	6	5	3	0	0.43	0.46	1.00
163	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD3E(1), CD3G(1), CD4(2)	2491905	5	5	5	2	0	2	1	1	1	0	0.71	0.48	1.00
164	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	JAK1(2), JAK2(5), STAT1(1)	6277167	8	8	8	1	0	0	2	2	4	0	0.65	0.48	1.00
165	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(3), PNPO(2)	3656484	5	5	5	1	0	0	3	1	1	0	0.62	0.49	1.00
166	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(3), GALNS(1), GLB1(1), GUSB(1), HEXB(1), IDS(3), IDUA(2), LCT(6), NAGLU(1)	11059191	19	17	19	2	4	4	4	6	1	0	0.059	0.50	1.00
167	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1)	1160523	1	1	1	0	0	0	0	0	1	0	0.88	0.51	1.00
168	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(3), CFTR(6), GNAS(5), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), SLC9A3R1(2)	9502194	19	19	19	4	3	2	4	6	4	0	0.48	0.52	1.00
169	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	16	PSMA1(1), PSMA3(2), PSMA5(1), PSMA6(1), PSMB6(2), PSMB8(1)	6059664	8	8	8	0	1	1	3	2	1	0	0.11	0.53	1.00
170	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), DAB1(3), LRP8(1), RELN(13), VLDLR(3)	10644465	21	20	20	4	4	3	8	3	3	0	0.24	0.54	1.00
171	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CCL11(1), CCR3(1), CD4(2), HLA-DRB1(4), IL5RA(1), IL6(2)	3598179	11	11	11	4	1	2	2	2	4	0	0.62	0.54	1.00
172	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(1), BAK1(1), BID(4), CASP6(2), CASP8(3), DFFB(2)	10306803	13	13	13	1	2	6	0	1	4	0	0.084	0.54	1.00
173	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1)	4275531	5	5	5	1	2	1	2	0	0	0	0.52	0.55	1.00
174	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(1), UBE2D2(2), UBE2E1(1), UBE2E3(1), UBE2J1(3), UBE2J2(1), UBE3A(1)	8021754	11	11	11	1	0	4	4	0	3	0	0.27	0.56	1.00
175	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(3), COASY(3), DPYD(1), DPYS(1), ENPP1(4), ENPP3(2), PANK2(1), PANK4(3), UPB1(3)	10425441	21	20	21	4	2	3	5	6	5	0	0.32	0.56	1.00
176	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(1), ARFGAP3(1), ARFGEF2(3), COPA(2), GBF1(4), GPLD1(3), KDELR3(1)	12398178	16	16	16	1	2	2	8	2	2	0	0.053	0.57	1.00
177	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), ACO2(3), CS(1), HAO1(3), HAO2(1), MDH2(2), MTHFD1(4), MTHFD1L(3)	10289565	18	16	18	3	2	8	5	2	1	0	0.10	0.57	1.00
178	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(3)	2888379	3	3	3	0	0	1	0	1	1	0	0.42	0.58	1.00
179	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(5), PTK2B(3)	5095350	9	9	9	2	1	3	3	0	2	0	0.33	0.58	1.00
180	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), NR1I3(1), PTGS1(1), PTGS2(1)	4016454	4	4	4	0	2	0	1	0	1	0	0.31	0.58	1.00
181	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), ENO1(1), GPI(2), HK1(1), PGK1(2), PKLR(1), TPI1(2)	7071129	11	11	11	3	1	3	2	2	3	0	0.39	0.59	1.00
182	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), TGDS(2), UXS1(2)	3062280	5	4	5	0	1	2	1	1	0	0	0.19	0.60	1.00
183	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), ACO2(3), CS(1), HAO1(3), HAO2(1), MDH2(2), MTHFD1(4), MTHFD1L(3)	9797268	18	16	18	3	2	8	5	2	1	0	0.11	0.61	1.00
184	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(2), ALDH1A2(1), BCMO1(4), RDH5(2)	2952768	9	9	9	6	1	1	4	0	3	0	0.95	0.61	1.00
185	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CDC25A(1), CDC25B(3), CDC25C(1), CDK7(2), MNAT1(1), XPO1(3)	6544356	13	13	13	3	2	2	7	1	1	0	0.56	0.62	1.00
186	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(4), ABAT(3), ADSL(2), AGXT(1), AGXT2(1), ASL(3), ASPA(2), CAD(7), CRAT(3), DARS(1), GAD1(2), GAD2(3), GOT2(1), GPT2(2), NARS(1), PC(3)	20201922	39	35	39	4	5	10	16	3	5	0	0.0036	0.62	1.00
187	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(1), FOSB(1), GRIA2(1)	2738307	3	3	3	1	0	1	1	1	0	0	0.69	0.63	1.00
188	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(3), SNCAIP(3)	4820049	8	8	8	2	1	2	4	1	0	0	0.61	0.64	1.00
189	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(2), FADS2(4), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2)	8089692	24	23	22	5	2	5	9	6	2	0	0.26	0.64	1.00
190	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(1), CYP11B1(2), CYP11B2(3), CYP17A1(1), CYP21A2(2), HSD11B1(2), HSD3B2(3)	7330206	15	15	15	3	2	1	10	2	0	0	0.34	0.64	1.00
191	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(1), CYP11B1(2), CYP11B2(3), CYP17A1(1), CYP21A2(2), HSD11B1(2), HSD3B2(3)	7330206	15	15	15	3	2	1	10	2	0	0	0.34	0.64	1.00
192	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA3(2), PSMA5(1), PSMA6(1), PSMB6(2), RPN1(2), UBE2A(1), UBE3A(1)	10095384	11	11	11	1	0	2	5	2	2	0	0.26	0.65	1.00
193	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ITGA4(1), ITGAL(1), ITGAM(1), ITGB1(2), ITGB2(3), SELE(1), SELL(4), SELP(5)	12628863	18	17	18	2	1	2	7	5	3	0	0.13	0.65	1.00
194	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), CD38(2), ENPP1(4), ENPP3(2), NADK(1), NMNAT1(1), NMNAT2(1), NNT(4), NT5C1B(4), NT5C3(1), NT5E(3)	16372044	26	26	26	4	1	1	16	6	2	0	0.25	0.66	1.00
195	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(2), EGFR(5), ERBB3(9), NRG1(1)	7743918	17	17	17	4	2	2	7	5	1	0	0.48	0.66	1.00
196	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BAD(1), BAK1(1), BCL2L11(2), BID(4), CES1(2)	8892780	11	11	11	1	3	4	1	1	2	0	0.18	0.66	1.00
197	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(1), NFKBIA(1), PLCB1(4), RELA(1)	6248268	8	8	8	1	2	2	2	0	2	0	0.30	0.66	1.00
198	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	IL10RA(1), IL10RB(3), IL1A(1), IL6(2), JAK1(2), STAT1(1), STAT3(1), STAT5A(3)	9038289	14	13	14	2	5	1	2	1	5	0	0.15	0.66	1.00
199	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(1), CD3G(1), CD8A(1), ITGAL(1), ITGB2(3), PTPRC(1)	8056230	10	10	10	1	0	2	3	3	2	0	0.20	0.67	1.00
200	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(3), ARHGDIB(1), CASP1(1), CASP8(3), JUN(1), PRF1(2)	9735414	12	12	12	2	2	2	1	3	4	0	0.33	0.67	1.00
201	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT2(1), TYR(4)	3565224	6	6	6	2	0	2	4	0	0	0	0.72	0.68	1.00
202	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX5(1), DPEP1(3), GGT1(2), PLA2G6(2), PTGDS(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(1)	12007281	15	15	14	1	4	1	6	1	3	0	0.045	0.68	1.00
203	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(1), CASP8(3), RIPK1(3), TNFRSF1A(1)	5615025	8	8	8	2	1	2	1	1	3	0	0.50	0.70	1.00
204	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ITGAL(1), ITGAM(1), ITGB2(3), SELE(1), SELL(4)	8400483	10	10	10	1	0	0	4	3	3	0	0.25	0.70	1.00
205	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(4), ALDOB(2), GOT2(1), GPT2(2), MDH2(2), ME2(2), ME3(2), PGK1(2), PKLR(1), TKT(1), TPI1(2)	13671255	21	21	21	3	5	8	7	0	1	0	0.027	0.70	1.00
206	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(3), GALNS(1), GLB1(1), GUSB(1), HEXB(1), HGSNAT(3), HPSE(4), HPSE2(1), HYAL1(1), HYAL2(1), IDS(3), IDUA(2), LCT(6), NAGLU(1)	15862509	29	26	29	4	5	5	8	9	2	0	0.078	0.71	1.00
207	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(2), CHAT(1), DBH(4), DDC(1), GAD1(2), GAD2(3), MAOA(2), PAH(1), SLC18A3(2)	10907598	18	18	18	3	4	4	6	2	2	0	0.17	0.71	1.00
208	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(1), NDUFB4(1), NDUFS2(2), NDUFV1(1), NDUFV2(1)	5507034	7	7	7	1	3	1	1	1	1	0	0.39	0.71	1.00
209	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(1), COQ6(2), NDUFA13(1)	3218436	4	4	4	0	0	1	2	1	0	0	0.36	0.71	1.00
210	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	1298427	1	1	1	1	1	0	0	0	0	0	0.93	0.72	1.00
211	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), MST1(3), MST1R(1)	4712565	6	5	6	0	2	1	2	0	1	0	0.19	0.72	1.00
212	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(4), G6PD(1), GCLC(2), GCLM(1), GGT1(2), GPX5(2), GSS(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTO2(1), GSTT1(1), GSTZ1(1), IDH1(1), PGD(2)	14330862	22	22	22	3	6	3	4	6	3	0	0.073	0.72	1.00
213	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(3), GOT2(1), LDHC(1)	5029947	5	5	5	0	0	1	1	0	3	0	0.27	0.72	1.00
214	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(4), CYP2A6(1), CYP2A7(1), XDH(3)	6165120	10	10	10	2	2	2	3	3	0	0	0.27	0.72	1.00
215	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(2), CD3E(1), CD3G(1), CD4(2), CXCR3(2), IL12A(1), IL12B(1), IL12RB1(3), JAK2(5), STAT4(5), TYK2(4)	11491155	28	24	27	7	1	5	5	9	8	0	0.41	0.72	1.00
216	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(2), ACPP(2), ACPT(2), ENPP1(4), ENPP3(2), TYR(4)	7538076	16	16	16	4	2	2	9	1	2	0	0.58	0.74	1.00
217	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(2), IFNAR1(1), IFNAR2(1), IFNB1(1), MAPK8(2), NFKB1(1), RELA(1), TNFRSF11A(2), TRAF6(2)	8162193	13	13	13	3	2	6	1	2	2	0	0.22	0.74	1.00
218	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA3(2), P2RY1(2), P2RY2(1), P2RY6(1)	4208607	7	7	7	2	2	2	1	2	0	0	0.39	0.75	1.00
219	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(4), CS(1), PC(3), PDHA1(2)	7122336	10	10	10	2	2	3	2	1	2	0	0.26	0.75	1.00
220	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), TGDS(2), UXS1(2)	3856749	5	4	5	0	1	2	1	1	0	0	0.20	0.76	1.00
221	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(1), NFKB1(1), NOX1(1), RELA(1), SOD1(1), XDH(3)	7397130	8	8	8	0	1	1	2	3	1	0	0.12	0.76	1.00
222	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), CHPT1(1), LCMT1(1), LCMT2(5), METTL2B(2), PCYT1A(1), PCYT1B(3), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), WBSCR22(2)	10546107	27	23	27	6	5	7	9	1	5	0	0.18	0.76	1.00
223	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), LPL(1), PPARG(1)	4101630	4	4	4	1	0	1	3	0	0	0	0.70	0.77	1.00
224	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS2(3), DHRS7(1), PON1(1), PON2(1), PON3(1), RDH11(2), RDH12(1), RDH14(1)	6806982	11	10	11	3	1	3	1	3	3	0	0.40	0.77	1.00
225	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(1), HK3(2), IMPA1(1), PGM1(2), PGM3(1), TGDS(2)	7859514	11	11	11	2	3	1	1	5	1	0	0.27	0.78	1.00
226	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ITGA4(1), ITGAL(1), ITGB1(2), ITGB2(3), SELE(1), SELL(4)	9516390	12	12	12	2	0	0	5	5	2	0	0.42	0.80	1.00
227	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(4), ALDOB(2), GCK(2), GMDS(2), HK1(1), HK3(2), KHK(1), PFKFB1(1), PFKFB3(1), PFKFB4(1), PFKM(4), PFKP(4), SORD(1), TPI1(2)	18792462	30	29	30	4	9	5	6	5	5	0	0.013	0.80	1.00
228	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), ACO2(3), IDH1(1), MDH2(2), SDHB(1), SUCLA2(1)	6888102	9	9	9	2	1	2	2	4	0	0	0.45	0.81	1.00
229	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), GSTZ1(1), HGD(1)	1722279	3	3	3	2	1	0	0	2	0	0	0.89	0.81	1.00
230	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(1), CASP8(3), JUN(1), MAP2K4(21), MAP3K7(1), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), NR2C2(1), RIPK1(3), TNFAIP3(1), TNFRSF1A(1)	19919523	39	37	38	9	5	7	6	2	18	1	0.44	0.82	1.00
231	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(1), AOC3(2), DDC(1), EPX(1), GOT2(1), HPD(1), LPO(5), MAOA(2), MAOB(1), MPO(2), PRDX1(1), PRDX5(1), TPO(6)	16810599	34	33	34	6	7	4	11	5	7	0	0.078	0.82	1.00
232	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(3), F2(3), F2R(2), FGA(3), FGG(1), PLAT(2), PLAU(2), PLG(4), SERPINE1(2)	10355475	23	23	23	5	1	4	13	4	1	0	0.37	0.82	1.00
233	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CD8A(1), CSF1(2), IL2(1), IL6(2)	4738422	8	8	8	3	0	2	3	1	2	0	0.65	0.82	1.00
234	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(3), AGT(3), BDKRB2(1), KNG1(3), NOS3(2)	7725159	12	12	12	3	0	3	4	3	2	0	0.44	0.83	1.00
235	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP68(2), SRP72(2), SRPR(7)	5730114	11	9	11	3	1	3	2	3	2	0	0.59	0.84	1.00
236	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(1), IFNAR2(1), IFNB1(1), JAK1(2), STAT1(1), STAT2(2), TYK2(4)	8247369	13	13	12	3	2	4	2	4	1	0	0.30	0.84	1.00
237	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), ENO3(2), FARS2(1), GOT2(1), PAH(1)	6288828	6	6	6	0	0	1	4	1	0	0	0.21	0.84	1.00
238	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(1), FARSB(3), GOT2(1), PAH(1)	6656910	7	7	7	1	1	1	5	0	0	0	0.37	0.84	1.00
239	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(1)	1990989	1	1	1	0	0	0	1	0	0	0	0.81	0.85	1.00
240	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(2), JAK2(5), JAK3(2), MAPK1(1), MAPK3(1), STAT3(1), TYK2(4)	8997222	16	15	15	4	4	1	3	4	4	0	0.48	0.86	1.00
241	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(3), CDK7(2), NEK1(1), WEE1(1)	5850780	8	8	8	2	1	2	4	1	0	0	0.63	0.86	1.00
242	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(12), BMPR1B(2), CDKN1B(5), DMC1(2), EGR1(1), ESR2(2), FSHR(4), GJA4(1), LHCGR(4), MLH1(1), MSH5(1), NCOR1(17), NRIP1(1), PGR(2), PRLR(1), ZP2(2)	25863591	58	53	57	10	3	11	7	8	28	1	0.10	0.87	1.00
243	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(1), APOBEC1(1), APOBEC2(1), APOBEC3A(1), APOBEC3B(1), APOBEC3G(1), APOBEC4(1)	5596266	7	7	7	2	4	1	0	1	1	0	0.65	0.87	1.00
244	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(1), IDI1(2), SQLE(1)	2524860	5	5	5	3	1	1	2	0	1	0	0.91	0.87	1.00
245	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(2), ACP6(1), ACPP(2), ACPT(2), ENPP1(4), ENPP3(2), MTMR2(1), MTMR6(1), TYR(4)	11605737	19	19	19	4	2	4	9	2	2	0	0.39	0.88	1.00
246	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(1), HADH(1), HADHB(1), HSD17B10(1), HSD17B4(4), PPT2(1)	6248775	10	10	10	3	0	3	4	2	1	0	0.65	0.88	1.00
247	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN2(8), ACTN3(1), ACTN4(4), ARHGAP5(3), CD99(2), CLDN11(1), CLDN15(1), CLDN17(1), CLDN19(1), CLDN5(1), CLDN6(2), CTNNA1(2), CTNNA2(4), CTNNA3(4), CTNND1(1), CYBB(1), ESAM(2), EZR(2), F11R(1), GNAI1(1), GNAI2(1), GRLF1(5), ITGA4(1), ITGAL(1), ITGAM(1), ITGB1(2), ITGB2(3), ITK(4), MAPK14(1), MLLT4(9), MMP9(1), MSN(1), MYL7(1), NCF1(1), NCF2(2), NOX1(1), NOX3(1), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PLCG1(5), PLCG2(2), PRKCG(2), PTK2(3), PTK2B(3), PTPN11(1), PXN(1), RAPGEF3(2), RAPGEF4(3), RASSF5(2), RHOA(2), ROCK1(1), ROCK2(2), SIPA1(1), TXK(1), VAV1(2), VAV2(1), VAV3(1), VCAM1(2), VCL(3)	95524884	334	263	171	57	25	90	48	125	46	0	7.72e-07	0.89	1.00
248	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1), BMPR1B(2), BMPR2(2)	4678089	5	5	4	3	0	2	0	0	3	0	0.77	0.89	1.00
249	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA3(2), PSMA5(1), PSMA6(1), PSMB6(2), PSMD1(5), PSMD11(1), PSMD2(1), PSMD6(2)	12322635	16	16	16	3	2	3	5	3	3	0	0.38	0.89	1.00
250	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(3), F2R(2), F5(11), F7(1), FGA(3), FGG(1), PROC(1), PROS1(1), SERPINC1(3), TFPI(1)	12507183	27	26	27	6	3	6	10	5	3	0	0.30	0.89	1.00
251	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(4), AARS2(3), ABAT(3), ADSL(2), AGXT(1), AGXT2(1), ASL(3), ASPA(2), ASS1(1), CAD(7), CRAT(3), DARS(1), DARS2(1), DLAT(1), DLD(1), GAD1(2), GAD2(3), GOT2(1), GPT2(2), NARS(1), NARS2(2), PC(3), PDHA1(2), PDHA2(2), PDHB(1)	29281785	53	47	53	6	9	14	21	4	5	0	0.0014	0.90	1.00
252	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(1), HK3(2), IMPA1(1), PGM1(2), PGM3(1), TGDS(2)	8939931	11	11	11	2	3	1	1	5	1	0	0.26	0.90	1.00
253	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3E(1), CD3G(1), CXCR3(2), ETV5(1), IL12A(1), IL12B(1), IL12RB1(3), IL18R1(1), JAK2(5), JUN(1), MAPK14(1), MAPK8(2), STAT4(5), TYK2(4)	14431755	30	27	29	8	2	4	5	9	10	0	0.49	0.91	1.00
254	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(5), GNB1(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	7183176	10	10	10	3	2	2	2	3	1	0	0.66	0.91	1.00
255	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(2), B4GALT3(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1)	5965869	7	7	7	2	0	3	1	1	2	0	0.61	0.91	1.00
256	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(2), RANGAP1(2)	6500247	5	5	5	0	0	1	2	0	2	0	0.50	0.92	1.00
257	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(4), B3GNT1(1), FUT2(2), ST8SIA1(1)	4617756	8	8	7	4	1	2	1	2	2	0	0.66	0.92	1.00
258	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7	CD4(2), HLA-DRB1(4), IL2(1)	2540070	7	7	7	4	0	1	2	3	1	0	0.83	0.92	1.00
259	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), FPGS(1), GCH1(1)	4874805	10	9	9	4	4	1	4	0	1	0	0.61	0.92	1.00
260	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(4), ACO1(1), ACO2(3), ACSS1(1), IDH1(1), MDH2(2), SUCLA2(1)	10182081	13	13	13	3	3	3	2	4	1	0	0.28	0.92	1.00
261	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH11(2), RDH12(1), RDH14(1)	3622515	4	4	4	2	0	1	0	2	1	0	0.79	0.92	1.00
262	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(2)	3333525	2	2	2	1	1	0	0	0	1	0	0.79	0.92	1.00
263	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(4), CD2(2), CD33(1), CD5(2), IFNA1(1), IFNB1(1), IL12A(1), IL12B(1), ITGAX(4), TLR2(1), TLR4(8), TLR7(5), TLR9(1)	14287767	32	29	31	8	6	8	3	7	8	0	0.24	0.93	1.00
264	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD3E(1), CD3G(1), CD4(2), ITGAL(1), ITGB2(3), PTPRC(1)	8599734	11	11	11	3	0	3	3	3	2	0	0.43	0.93	1.00
265	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(1), JUN(1), KEAP1(1), MAPK1(1), MAPK14(1), MAPK8(2)	6891651	7	7	7	2	2	1	1	0	2	1	0.55	0.93	1.00
266	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR2(1), MTMR6(1), NFS1(1), TPK1(1)	4912323	4	4	4	1	0	3	1	0	0	0	0.53	0.93	1.00
267	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3E(1), CD3G(1), IL2(1), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2), TOB1(1)	8187543	12	11	12	3	1	4	3	3	1	0	0.39	0.93	1.00
268	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), GLB1(1), HEXB(1), LCT(6), ST3GAL1(1), ST3GAL5(2), ST6GALNAC4(1), ST8SIA1(1)	12360660	15	15	15	3	2	2	4	5	2	0	0.35	0.94	1.00
269	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS2(2), CDO1(1), CTH(3), GOT2(1), LDHC(1)	9442368	8	7	8	1	0	2	2	0	4	0	0.39	0.94	1.00
270	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), CASP8(3), DFFB(2), PRF1(2), SCAP(3), SREBF2(4)	13882674	15	14	15	2	1	8	2	1	3	0	0.073	0.94	1.00
271	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), EPOR(2), GRIN1(1), HIF1A(1), JAK2(5), NFKB1(1), NFKBIA(1), RELA(1)	10032516	14	14	14	3	1	4	2	2	5	0	0.42	0.94	1.00
272	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(3), GNAS(5), GNB1(1), PRKACA(1), PRKAR1A(1)	4554381	11	11	11	4	3	2	1	4	1	0	0.77	0.94	1.00
273	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(2), CAMK1G(1), HDAC9(3), MEF2A(1), MEF2C(2)	6323811	9	9	9	3	1	2	2	1	3	0	0.62	0.94	1.00
274	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1)	2774811	1	1	1	1	1	0	0	0	0	0	0.86	0.94	1.00
275	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(2), IL6(2), LDLR(1), LPL(1)	3987048	7	7	7	5	0	3	2	0	2	0	0.94	0.95	1.00
276	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(1), IDI1(2), SQLE(1)	3343158	5	5	5	4	1	1	2	0	1	0	0.97	0.95	1.00
277	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAPK14(1), MAPK8(2), NFKB1(1), RELA(1), TNFSF13B(1), TRAF3(1), TRAF6(2)	11171238	9	9	9	1	1	3	1	1	3	0	0.18	0.95	1.00
278	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(2), ACP6(1), ACPP(2), ACPT(2), ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), CYP3A4(3), CYP3A43(1), CYP3A7(4), DHRS2(3), DHRS7(1), PON1(1), PON2(1), PON3(1)	13847691	30	24	29	7	7	5	10	4	4	0	0.22	0.95	1.00
279	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT2(2), GBGT1(1), GLA(2), HEXB(1), ST3GAL1(1), ST3GAL4(1), ST8SIA1(1)	7505628	10	10	9	4	1	2	1	2	4	0	0.62	0.95	1.00
280	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), ELK1(2), EPOR(2), GRB2(1), JAK2(5), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), PLCG1(5), RAF1(1), SHC1(1), SOS1(4), STAT5A(3), STAT5B(4)	16707678	34	32	34	7	8	6	6	3	11	0	0.11	0.95	1.00
281	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(3), CS(1), OGDH(2), SDHA(1), SUCLA2(1)	7334769	8	7	8	2	1	2	4	1	0	0	0.46	0.95	1.00
282	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(1)	3762954	2	2	2	4	0	0	0	0	2	0	1.00	0.95	1.00
283	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(4), ESR1(2), GREB1(2), MTA3(2)	8166756	10	10	10	3	0	5	3	1	1	0	0.36	0.96	1.00
284	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(3), ALDH5A1(1), CAD(7), CPS1(5), EPRS(2), GAD1(2), GAD2(3), GCLC(2), GCLM(1), GFPT1(1), GLS(1), GMPS(1), GOT2(1), GPT2(2), GSS(1), PPAT(1), QARS(2)	25419459	36	33	36	4	3	7	13	10	3	0	0.021	0.96	1.00
285	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), JUN(1), MAPK14(1), THBS1(4)	5482698	7	6	7	3	0	0	1	4	2	0	0.91	0.96	1.00
286	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(2), CAPN1(3), CDK5(1), MAPT(1), PPP2CA(1)	7232862	8	8	8	2	2	2	2	1	1	0	0.57	0.96	1.00
287	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(1), B3GALT5(1), FUT2(2), GBGT1(1), GLA(2), HEXB(1), ST3GAL1(1), ST8SIA1(1)	7963956	11	11	10	5	1	1	3	2	4	0	0.78	0.96	1.00
288	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(2), AASS(3)	3628599	5	5	5	3	1	1	2	0	1	0	0.93	0.96	1.00
289	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(2), CAMK1G(1), ELK1(2), FPR1(1), GNB1(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP3K1(47), MAPK1(1), MAPK14(1), MAPK3(1), NCF1(1), NCF2(2), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NFKB1(1), NFKBIA(1), PAK1(2), PIK3C2G(2), PLCB1(4), PPP3CA(3), PPP3CB(3), RAF1(1), RELA(1)	29322852	90	77	89	20	7	11	15	14	28	15	0.54	0.96	1.00
290	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	JAK1(2), JAK2(5), PTPRU(5), REG1A(1), STAT1(1)	8791380	14	14	14	4	2	2	2	3	5	0	0.73	0.96	1.00
291	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(1), AASDHPPT(2), AASS(3)	5308290	6	6	6	3	1	1	2	0	2	0	0.93	0.96	1.00
292	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(2), SULT1A2(1), SULT1E1(2), SUOX(3)	4635501	9	9	9	3	2	5	0	1	1	0	0.61	0.97	1.00
293	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(3), BCAT2(2), COASY(3), DPYD(1), DPYS(1), ENPP1(4), ENPP3(2), ILVBL(2), PANK2(1), PANK4(3), UPB1(3), VNN1(3)	13100880	28	27	28	7	5	4	6	8	5	0	0.39	0.97	1.00
294	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(1), AOC2(1), AOC3(2), CES1(2), ESD(1)	4369833	7	7	7	3	2	1	3	0	1	0	0.68	0.97	1.00
295	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(4), ALDOB(2), G6PD(1), GPI(2), H6PD(2), PFKM(4), PFKP(4), PGD(2), PGLS(2), PGM1(2), PGM3(1), PRPS2(1), TKT(1)	14936220	28	27	28	7	11	4	3	6	4	0	0.18	0.97	1.00
296	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), CHST1(1), CHST2(3), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1)	8765523	14	14	14	4	2	5	2	2	3	0	0.46	0.97	1.00
297	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLUD2(1)	3398421	2	2	2	2	0	0	0	1	1	0	0.93	0.97	1.00
298	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(1), CREBBP(2), DFFB(2), GZMA(1), HMGB2(1), PRF1(2), SET(1)	8268156	10	9	10	3	1	2	2	2	3	0	0.67	0.97	1.00
299	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), ACO2(3), CS(1), DLD(1), IDH1(1), IDH3A(1), IDH3G(1), MDH2(2), PC(3), PCK1(1), SDHA(1), SDHB(1), SUCLA2(1)	15959346	18	17	18	3	4	3	5	5	1	0	0.16	0.97	1.00
300	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(2)	4405830	2	2	2	1	1	0	0	0	1	0	0.81	0.98	1.00
301	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3E(1), CD3G(1), HLA-A(6), ITGAL(1), ITGB2(3), PRF1(2)	6501768	16	14	15	6	3	3	2	4	4	0	0.64	0.98	1.00
302	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(2), GALNT3(2), GALNT4(1), GALNT7(2), GALNT9(1), ST3GAL1(1), ST3GAL4(1), WBSCR17(4)	11218896	14	14	14	8	1	2	3	2	6	0	0.91	0.98	1.00
303	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	EGF(2), EGFR(5), ETS1(2), ETS2(4), HOXA7(1), IKBKB(3), JUN(1), MAP2K1(1), MAP2K3(1), MAP2K4(21), MAP2K7(1), MAP3K1(47), MAP3K5(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(1), NFKBIA(1), PPP2CA(1), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(3), RAF1(1), RELA(1), RIPK1(3), SP1(2), TNFRSF1A(1)	37109358	114	95	112	26	10	14	13	19	43	15	0.48	0.98	1.00
304	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(4), GAD1(2)	4551339	6	6	6	3	2	1	1	1	1	0	0.86	0.98	1.00
305	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(1), FAS(1), FASLG(1), IL1A(1), MAPKAPK3(1)	8276775	6	6	6	1	1	2	3	0	0	0	0.42	0.98	1.00
306	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(1), EGR1(1), KLK2(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1)	6272604	10	10	10	4	2	3	1	3	1	0	0.57	0.98	1.00
307	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(2), CMAS(1), CTBS(1), CYB5R1(2), GFPT1(1), GFPT2(3), GNE(3), GNPNAT1(1), HEXB(1), HK1(1), HK3(2), MTMR2(1), MTMR6(1), NAGK(1), NANS(1), PGM3(1), RENBP(1), UAP1(1)	22232457	26	25	26	3	3	5	6	9	3	0	0.043	0.98	1.00
308	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(1), BRAF(3), CREB1(1), CREB3(1), MAPK1(1), RAF1(1), SNX13(3), TERF2IP(2)	8786817	14	14	14	4	2	2	4	5	1	0	0.57	0.98	1.00
309	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(3), C5(3), C6(4), C7(5), IL1A(1), IL6(2), ITGA4(1), ITGAL(1), ITGB1(2), ITGB2(3), SELP(5), SELPLG(1), VCAM1(2)	18880173	33	30	33	8	6	7	7	7	6	0	0.17	0.98	1.00
310	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(1), CDC25B(3), CDC25C(1), GRB2(1), PTPRA(1)	7097493	9	9	9	3	3	0	4	1	1	0	0.66	0.98	1.00
311	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(1), GNAQ(1), GNAS(5), GNB1(1), LIMK1(3), MAP2K1(1), MAPK1(1), MAPK3(1), NOX1(1), PIK3C2G(2), PLCB1(4), PTK2(3), RAF1(1), ROCK2(2)	19387680	28	27	28	5	5	9	5	6	3	0	0.14	0.99	1.00
312	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(3), IGF1(1), IL1A(1), IL6(2), KITLG(2), TGFB3(1)	6551454	10	8	10	4	2	2	2	2	2	0	0.68	0.99	1.00
313	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1)	10151661	10	10	10	3	2	3	5	0	0	0	0.54	0.99	1.00
314	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(1), ELK1(2), GRB2(1), IL6(2), IL6R(1), IL6ST(3), JAK1(2), JAK2(5), JAK3(2), JUN(1), MAP2K1(1), MAPK3(1), PTPN11(1), RAF1(1), SHC1(1), SOS1(4), SRF(1), STAT3(1)	18178485	31	29	31	6	5	4	9	5	8	0	0.22	0.99	1.00
315	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	DFFB(2), HMGB2(1), TOP2A(1)	8107437	4	4	4	0	0	2	1	1	0	0	0.32	0.99	1.00
316	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(1), IL12A(1), IL12B(1), IL15(1), IL1A(1), IL2(1), IL6(2), LTA(1)	7216638	10	9	10	5	2	2	1	2	3	0	0.84	0.99	1.00
317	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(6), NRG3(2), PSEN1(1)	6965673	9	9	9	3	0	4	4	1	0	0	0.59	0.99	1.00
318	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(1), DHRS2(3), DHRS7(1), LCMT1(1), LCMT2(5), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), WBSCR22(2)	11206728	26	23	26	7	6	7	7	1	5	0	0.26	0.99	1.00
319	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(12), GRB2(1), IL2RG(1), IL4R(1), IRS1(1), JAK1(2), JAK3(2), SHC1(1), STAT6(1)	11131185	22	21	12	6	2	12	2	4	2	0	0.21	0.99	1.00
320	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(2), GFPT1(1), GNE(3), HEXB(1), HK1(1), HK3(2), PGM3(1), RENBP(1), UAP1(1)	13241319	14	14	14	3	3	1	3	5	2	0	0.40	0.99	1.00
321	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(3), ACACB(8), FASN(3), MCAT(1), OLAH(1)	12471186	16	16	16	4	6	0	7	2	1	0	0.40	0.99	1.00
322	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	127	ACACA(3), ACACB(8), AKT1(12), AKT2(1), AKT3(3), ARAF(1), BAD(1), BRAF(3), CBL(1), CBLB(9), CBLC(3), CRKL(1), ELK1(2), EXOC7(2), FASN(3), G6PC2(2), GCK(2), GRB2(1), GYS1(5), GYS2(1), IKBKB(3), INPP5D(3), INSR(2), IRS1(1), IRS4(4), KRAS(4), LIPE(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MKNK2(1), PCK1(1), PCK2(1), PDE3A(7), PDE3B(1), PFKM(4), PFKP(4), PHKA1(1), PHKA2(4), PHKB(2), PHKG2(1), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PKLR(1), PPARGC1A(2), PPP1R3A(7), PPP1R3B(1), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACA(1), PRKAG2(1), PRKAG3(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCI(1), PRKCZ(1), PRKX(1), PTPRF(5), PYGB(3), PYGL(1), PYGM(4), RAF1(1), RAPGEF1(3), RHEB(1), RPS6(2), RPS6KB2(4), SH2B2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SLC2A4(1), SOCS4(1), SORBS1(4), SOS1(4), SOS2(2), TRIP10(4), TSC1(3), TSC2(2)	122263557	409	287	235	70	46	116	63	141	43	0	7.70e-09	0.99	1.00
323	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ARG1(2), GLS(1)	4389606	3	3	3	3	1	0	1	0	1	0	0.96	0.99	1.00
324	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(2), GRB2(1), IL3RA(1), JAK2(5), MAP2K1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(4), STAT5A(3), STAT5B(4)	13669734	24	24	24	6	6	3	4	3	8	0	0.26	0.99	1.00
325	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(3), ALDH1B1(1), ALDH9A1(1)	6444984	5	5	5	2	0	2	3	0	0	0	0.72	0.99	1.00
326	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(2), IL6R(1), JAK1(2), JAK2(5), JAK3(2), PTPRU(5), REG1A(1), STAT3(1)	11702574	19	19	19	8	4	2	3	3	7	0	0.85	0.99	1.00
327	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCR5(1), GNAQ(1), JUN(1), MAPK14(1), MAPK8(2), PLCG1(5), PTK2B(3)	10322013	14	14	14	5	2	2	5	0	5	0	0.67	0.99	1.00
328	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(3), ADC(1), ALDH5A1(1), CAD(7), CPS1(5), EARS2(3), EPRS(2), GAD1(2), GAD2(3), GCLC(2), GCLM(1), GFPT1(1), GFPT2(3), GLS(1), GLUD2(1), GMPS(1), GNPNAT1(1), GOT2(1), GPT2(2), GSS(1), NAGK(1), PPAT(1), QARS(2)	30338880	46	42	46	6	4	9	15	15	3	0	0.015	1.00	1.00
329	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS2(3), HMBS(1), PPOX(1)	5985642	5	5	5	2	2	0	3	0	0	0	0.85	1.00	1.00
330	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	21	ARSA(1), ARSB(3), ARSE(2), ASAH1(1), GAL3ST1(1), GLA(2), GLB1(1), LCT(6), NEU2(1), PPAP2A(1), PPAP2C(2), SMPD2(2), SPTLC1(1), SPTLC2(2)	17037228	26	22	26	5	7	4	8	5	2	0	0.16	1.00	1.00
331	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT1(2), B4GALT3(1), DPAGT1(2), MAN1A1(1), MAN1B1(1), MGAT3(1), MGAT4B(1), MGAT5(2), RPN1(2)	14519973	14	14	14	3	2	3	4	2	3	0	0.37	1.00	1.00
332	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), GPD2(1), NDUFA1(1), SDHA(1), SDHB(1), UQCRC1(2)	4929561	7	7	7	5	2	0	2	2	1	0	0.96	1.00	1.00
333	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(2), JUN(1), MAPK3(1), OPRK1(2), POLR2A(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	9807915	12	12	12	4	4	0	5	2	1	0	0.67	1.00	1.00
334	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(4), CREB1(1), EDN1(2), EP300(3), HIF1A(1), JUN(1), NOS3(2), P4HB(1)	13061334	17	16	16	5	1	4	3	3	6	0	0.67	1.00	1.00
335	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), ARHGDIB(1), CASP1(1), CASP2(3), CASP6(2), CASP8(3), DFFB(2), LMNB1(1), PRF1(2)	14685762	16	16	16	4	1	6	3	3	3	0	0.37	1.00	1.00
336	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(2), JAK2(5), JAK3(2), PTPRU(5), REG1A(1), SOAT1(1)	10616580	16	16	16	5	3	3	2	3	5	0	0.64	1.00	1.00
337	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(2), EP300(3), HDAC3(2), IKBKB(3), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(3), TNFRSF1A(1), TRAF6(2)	16605771	19	19	18	4	2	6	4	2	5	0	0.20	1.00	1.00
338	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(2), CSF1(2), HLA-DRB1(4), IFNA1(1), IFNB1(1), IL12A(1), IL12B(1), IL15(1), IL1A(1), IL2(1), IL6(2), LTA(1), TGFB3(1)	9655308	19	18	19	7	2	5	4	4	4	0	0.58	1.00	1.00
339	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS2(3), HMBS(1)	6471855	4	4	4	2	2	0	2	0	0	0	0.87	1.00	1.00
340	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(1), ARG1(2), ARG2(1), ASL(3), CKMT2(2), CPS1(5), GATM(4), OTC(1)	13674297	21	21	21	5	2	4	8	6	1	0	0.37	1.00	1.00
341	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(3), IARS(6), LARS(1), LARS2(2), PDHA1(2), PDHA2(2), PDHB(1)	7646574	17	15	17	6	3	5	4	3	2	0	0.62	1.00	1.00
342	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), GRB2(1), PTK2B(3), SHC1(1), SOS1(4)	6669078	10	10	10	4	2	3	3	1	1	0	0.69	1.00	1.00
343	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNB1(1), JAK1(2), PTPRU(5), REG1A(1), STAT1(1), STAT2(2), TYK2(4)	9504729	17	17	16	5	4	4	2	5	2	0	0.45	1.00	1.00
344	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(2), CTH(3), GGT1(2), MAT1A(1), MAT2B(1), PAPSS1(2), SEPHS1(1)	9499152	13	13	13	7	4	3	2	0	4	0	0.75	1.00	1.00
345	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	11	GLB1(1), HEXB(1), LCT(6), MANBA(1), NEU2(1)	11416626	10	10	10	3	1	1	3	3	2	0	0.70	1.00	1.00
346	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD86(2), HLA-DRB1(4), IL12A(1), IL12B(1), IL12RB1(3), IL18R1(1), IL2(1), IL4R(1)	9285198	14	14	14	7	0	1	5	5	3	0	0.90	1.00	1.00
347	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAA2(1), ACAT1(1), ECHS1(1), EHHADH(2), HADHB(1)	6467292	7	7	7	6	0	1	2	3	1	0	0.97	1.00	1.00
348	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(3), GNAS(5), PLCE1(7), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RAP2B(1)	10785918	19	19	19	6	4	3	3	6	3	0	0.65	1.00	1.00
349	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ACTG2(2), ADCY3(2), ADCY9(5), ARF1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), ERO1L(3), GNAS(5), PDIA4(2), PLCG1(5), PLCG2(2), SEC61A1(2), TRIM23(2)	28196298	42	40	42	9	8	6	15	5	8	0	0.15	1.00	1.00
350	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(4), ALDOB(2), GOT2(1), GPT2(2), MDH2(2), ME3(2), PGK1(2), PKLR(1), TKT(1), TKTL1(1), TKTL2(1), TPI1(2)	15269319	21	21	21	5	5	8	6	1	1	0	0.12	1.00	1.00
351	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(1), ACY1(2), ADC(1), AGMAT(1), ALDH18A1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(2), ARG1(2), ARG2(1), ASL(3), ASS1(1), CPS1(5), GATM(4), MAOA(2), MAOB(1), OTC(1), SAT1(2), SAT2(1)	22414977	38	36	38	9	4	8	14	9	3	0	0.22	1.00	1.00
352	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ARG1(2), ARG2(1), ASL(3), ASS1(1), CKMT2(2), CPS1(5), DAO(1), EPRS(2), GATM(4), GLUD2(1), GOT2(1), NOS1(3), NOS3(2), OTC(1), P4HA2(1), P4HA3(1), PARS2(1), PYCR2(1), PYCRL(3), RARS(2), RARS2(2)	27808950	40	39	39	8	7	7	17	7	2	0	0.12	1.00	1.00
353	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(3), C5(3), C6(4), C7(5), C9(1)	9793719	16	16	16	5	3	5	3	2	3	0	0.48	1.00	1.00
354	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), FURIN(1), NOTCH1(2), PSEN1(1)	7103577	5	5	5	2	0	2	1	2	0	0	0.71	1.00	1.00
355	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(4), B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), FUT2(2), FUT3(4), FUT5(1), ST3GAL6(1), ST8SIA1(1)	11992071	21	21	20	7	4	5	3	6	3	0	0.38	1.00	1.00
356	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ARPC1A(1), ARPC1B(1), ARPC2(2), WASF1(3), WASL(1)	6290856	9	9	9	7	1	2	5	0	1	0	0.99	1.00	1.00
357	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	9	CD3E(1), CD3G(1), CD4(2), HLA-DRB1(4), PTPRC(1), ZAP70(1)	6334458	10	10	10	6	1	3	2	3	1	0	0.82	1.00	1.00
358	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CRY1(1), CSNK1E(2), PER1(3)	6447519	7	7	7	4	1	1	2	2	1	0	0.91	1.00	1.00
359	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	BPNT1(1), CHST11(1), PAPSS1(2), SULT1A1(1), SULT1A2(1), SULT1E1(2), SUOX(3)	6452082	11	11	11	7	3	5	0	2	1	0	0.89	1.00	1.00
360	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2D(3), CAMK2G(1), CAMKK1(3), CAMKK2(2), CREB1(1)	8972379	14	14	14	8	3	2	1	5	3	0	0.93	1.00	1.00
361	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	JUN(1), MAP2K1(1), MAPK1(1), MAPK3(1), MYC(1), NFKB1(1), NFKBIA(1), PLCB1(4), RAF1(1), RELA(1)	11439948	13	12	13	4	3	5	1	1	3	0	0.42	1.00	1.00
362	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(2), EP300(3), ESR1(2), MAPK1(1), MAPK3(1), PELP1(2)	11543883	11	11	10	5	1	4	2	0	4	0	0.77	1.00	1.00
363	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(5), PRKAR2A(1), PRKAR2B(1)	7605000	7	7	7	3	1	4	1	1	0	0	0.62	1.00	1.00
364	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(4), G6PD(1), GCLC(2), GCLM(1), GGT1(2), GPX5(2), GSS(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTK1(1), GSTO2(1), GSTT1(1), GSTZ1(1), IDH1(1), OPLAH(4), TXNDC12(1)	17365257	26	25	25	6	7	4	6	6	3	0	0.19	1.00	1.00
365	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(3), DHRS7(1), ESCO1(3), MYST3(2), MYST4(6), PNPLA3(2)	12345957	17	16	17	5	3	4	3	4	2	1	0.50	1.00	1.00
366	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(3), CPT1A(3), LEPR(3), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1)	11043981	15	15	15	7	6	1	4	1	3	0	0.90	1.00	1.00
367	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(2), ACTG1(1), ARHGEF2(2), CD14(1), CDH1(33), CTTN(1), EZR(2), HCLS1(1), ITGB1(2), KRT18(1), NCK1(1), NCK2(1), NCL(2), RHOA(2), ROCK1(1), ROCK2(2), TLR4(8), TLR5(1), TUBA1B(2), TUBA1C(2), TUBA3C(2), TUBA3D(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1), WAS(2), WASL(1)	39342693	87	77	83	20	7	10	20	8	42	0	0.29	1.00	1.00
368	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(2), ACTG1(1), ARHGEF2(2), CD14(1), CDH1(33), CTTN(1), EZR(2), HCLS1(1), ITGB1(2), KRT18(1), NCK1(1), NCK2(1), NCL(2), RHOA(2), ROCK1(1), ROCK2(2), TLR4(8), TLR5(1), TUBA1B(2), TUBA1C(2), TUBA3C(2), TUBA3D(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1), WAS(2), WASL(1)	39342693	87	77	83	20	7	10	20	8	42	0	0.29	1.00	1.00
369	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), F2R(2), GNAI1(1), GNB1(1), ITGA1(4), ITGB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), PLA2G4A(7), PLCB1(4), PTGS1(1), PTK2(3), RAF1(1), SYK(2), TBXAS1(1)	18573438	35	29	34	9	3	9	17	4	2	0	0.35	1.00	1.00
370	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(3), CSF1(2), IL6R(1), SELL(4), SPN(2), TNFRSF1A(1), TNFRSF8(1)	10020348	14	14	13	5	1	2	7	1	3	0	0.71	1.00	1.00
371	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	29	AGPAT3(2), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(5), ENPP6(1), PAFAH1B1(2), PAFAH1B3(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLD1(1), PPAP2A(1), PPAP2C(2)	17659824	34	31	32	9	3	9	9	10	3	0	0.27	1.00	1.00
372	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(3), CS(1), DLAT(1), DLD(1), IDH3A(1), IDH3G(1), MDH2(2), OGDH(2), PC(3), PDHA1(2), PDHA2(2), PDHB(1), PDHX(1), PDK1(1), PDK2(1), PDK4(2), PDP2(1), SDHA(1), SDHB(1), SUCLA2(1)	22026108	29	28	29	6	7	7	8	6	1	0	0.12	1.00	1.00
373	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(4), ACO1(1), ACO2(3), CLYBL(2), CS(1), DLD(1), IDH1(1), IDH3A(1), IDH3G(1), MDH2(2), OGDH(2), OGDHL(2), PC(3), PCK1(1), PCK2(1), SDHA(1), SDHB(1), SUCLA2(1)	23066979	29	27	29	6	6	5	8	8	2	0	0.13	1.00	1.00
374	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(1), CCR2(4), CCR3(1), CCR5(1), CCR7(2), CD4(2), CXCR3(2), IL12A(1), IL12B(1), IL12RB1(3), IL18R1(1), IL2(1), IL4R(1), TGFB3(1)	15566421	22	21	22	9	1	6	3	6	6	0	0.68	1.00	1.00
375	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), ELK1(2), GRB2(1), IL2(1), IL2RB(1), IL2RG(1), JAK1(2), JAK3(2), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(2), RAF1(1), SHC1(1), SOS1(4), STAT5A(3), STAT5B(4), SYK(2)	17964531	31	29	31	8	8	3	7	5	8	0	0.25	1.00	1.00
376	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1)	9978774	10	9	10	8	2	1	2	2	3	0	0.97	1.00	1.00
377	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(1), CALCR(1), CALCRL(2), CD97(5), CRHR1(3), CRHR2(1), ELTD1(4), EMR1(2), EMR2(6), GHRHR(1), GIPR(1), GPR64(6), LPHN1(2), LPHN2(6), LPHN3(6), VIPR1(1)	21354333	48	45	48	12	5	5	21	7	9	1	0.27	1.00	1.00
378	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREB1(1), CREBBP(2), EP300(3), NCOA3(6), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RARA(1)	15839187	17	15	16	6	2	2	5	2	6	0	0.80	1.00	1.00
379	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2B5(1), EIF2S1(1), EIF2S2(1), EIF2S3(1), EIF5(2)	8613930	7	7	7	3	1	2	3	0	1	0	0.88	1.00	1.00
380	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(3), GNAS(5), GNB1(1), PPP2CA(1), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	11333478	19	18	19	8	6	3	3	5	2	0	0.85	1.00	1.00
381	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), CA2(1), CA4(1), CA6(2), CA9(3), CPS1(5), CTH(3), GLS(1), HAL(2)	14374464	20	20	20	6	1	3	7	4	5	0	0.54	1.00	1.00
382	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	GNAQ(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), PLCG1(5), PPP3CA(3), PPP3CB(3), SP1(2), SP3(3)	14982357	26	24	26	9	1	5	8	7	5	0	0.74	1.00	1.00
383	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	FDFT1(1), FDPS(1), HMGCR(1), HMGCS1(1), IDI1(2), LSS(2), NSDHL(1), PMVK(1), SC4MOL(1), SQLE(1)	10188672	12	12	12	9	2	1	4	3	2	0	0.98	1.00	1.00
384	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD9(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), DHRS2(3), DHRS7(1), ESCO1(3), MYST3(2), MYST4(6), PNPLA3(2)	18805644	23	22	23	6	5	5	6	4	2	1	0.38	1.00	1.00
385	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A4(2), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), FDXR(3)	12375363	11	11	10	4	3	1	4	1	2	0	0.72	1.00	1.00
386	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QB(1), C2(1), C3(3), C5(3), C6(4), C7(5), C9(1), MASP1(1), MASP2(1), MBL2(1)	15956811	21	21	21	6	5	6	3	3	4	0	0.31	1.00	1.00
387	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	FDFT1(1), FDPS(1), HMGCR(1), IDI1(2), LSS(2), NQO1(1), NQO2(1), PMVK(1), SQLE(1), VKORC1(1)	8503404	12	12	12	7	3	2	4	2	1	0	0.91	1.00	1.00
388	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(1), EHHADH(2), HADH(1), HSD17B10(1), HSD17B4(4), NTAN1(1), SIRT1(1), SIRT7(1), VNN2(3)	9111297	15	15	15	6	0	4	7	3	1	0	0.81	1.00	1.00
389	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAA2(1), ACAD9(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), AKR1C4(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(1), LIPA(1), RDH11(2), RDH12(1), RDH14(1), SLC27A5(2), SOAT1(1), SRD5A1(1), SRD5A2(3)	24276174	30	29	30	8	3	9	9	5	4	0	0.31	1.00	1.00
390	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1C4(1), ARSB(3), ARSE(2), CYP11B1(2), CYP11B2(3), HSD11B1(2), HSD17B2(1), HSD3B2(3), SRD5A1(1), SRD5A2(3), SULT1E1(2), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2B15(3), UGT2B4(2)	20441226	33	29	33	9	5	6	14	6	2	0	0.34	1.00	1.00
391	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(2), EP300(3), LPL(1), NCOA1(1), NCOA2(1), PPARG(1)	14134146	9	9	8	5	0	2	3	0	4	0	0.89	1.00	1.00
392	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BAD(1), BRAF(3), CREB1(1), CREB3(1), DUSP4(1), DUSP6(1), DUSP9(1), EEF2K(3), GRB2(1), MAP2K1(1), MAP2K2(1), MAP3K8(2), MAPK1(1), MAPK3(1), MKNK2(1), MOS(2), NFKB1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), SHC1(1), SOS1(4), SOS2(2), TRAF3(1)	22739964	36	33	36	9	8	6	11	5	6	0	0.24	1.00	1.00
393	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG5(1), ATG7(2), GABARAP(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), PIK3C3(2), PIK3R4(3), PRKAA1(1), PRKAA2(3), ULK1(2), ULK2(1)	16487640	27	26	27	8	2	8	9	4	4	0	0.56	1.00	1.00
394	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), ARHGEF1(5), GNAQ(1), GNB1(1), MYLK(6), PLCB1(4), ROCK1(1)	15895464	21	21	21	6	3	4	7	3	4	0	0.43	1.00	1.00
395	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABARAP(1), GABRA1(2), GABRA3(3), GABRA5(1), GABRA6(3), GPHN(1), NSF(1), UBQLN1(1)	9217767	15	15	15	6	2	3	4	5	1	0	0.72	1.00	1.00
396	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(3), CAP1(2), CCNB1(2), CDC25C(1), GNAI1(1), GNAS(5), GNB1(1), MAPK1(1), MAPK3(1), MYT1(2), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RPS6KA1(1)	15401139	24	23	24	8	6	4	8	4	2	0	0.57	1.00	1.00
397	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QB(1), C2(1), C3(3), C5(3), C6(4), C7(5), C9(1)	12920388	18	18	18	6	4	6	3	2	3	0	0.46	1.00	1.00
398	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	9	CR1(8), CR2(2), HLA-DRB1(4), ITGAL(1), ITGB2(3), PTPRC(1)	11269596	19	19	19	7	0	4	7	6	2	0	0.65	1.00	1.00
399	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(3), EGF(2), EGFR(5), HGS(3), TF(1), TFRC(1)	9799296	15	15	15	7	4	2	5	3	1	0	0.81	1.00	1.00
400	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(1), MBTPS1(1), MBTPS2(2), SCAP(3), SREBF2(4)	9118902	12	12	12	8	0	4	6	1	1	0	0.92	1.00	1.00
401	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), CA2(1), CA4(1), CA6(2), CA9(3), CPS1(5), CTH(3), GLS(1), GLUD2(1), HAL(2)	16039959	21	21	21	7	1	3	7	5	5	0	0.61	1.00	1.00
402	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(1), CBS(2), CTH(3), DNMT1(1), DNMT3A(3), DNMT3B(1), MAT1A(1), MAT2B(1), MTR(5)	13484679	19	18	19	8	4	2	6	3	4	0	0.74	1.00	1.00
403	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD2(1), POLE(5), POLG(1), POLL(1), POLQ(6)	12791103	15	15	15	6	1	2	6	3	3	0	0.80	1.00	1.00
404	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QB(1), C2(1), C3(3), C5(3), C6(4), C7(5), C9(1), MASP1(1)	15421419	19	19	19	6	4	6	3	2	4	0	0.41	1.00	1.00
405	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CRY1(1), CSNK1E(2), NPAS2(1), NR1D1(2), PER1(3), PER2(3), PER3(2)	12820002	15	15	15	7	4	1	3	4	3	0	0.85	1.00	1.00
406	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(2), ACOX3(2), ELOVL5(3), ELOVL6(2), FADS2(4), FASN(3), SCD(1)	11350716	18	18	18	7	2	3	9	2	2	0	0.75	1.00	1.00
407	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(1), AOC3(2), DDC(1), EPX(1), ESCO1(3), GOT2(1), HPD(1), LPO(5), MAOA(2), MAOB(1), MPO(2), MYST3(2), MYST4(6), PNPLA3(2), TPO(6)	25729236	45	41	45	10	9	7	14	7	7	1	0.13	1.00	1.00
408	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(9), MAP2(7), PPP2CA(1), PRKAR2A(1), PRKAR2B(1), PRKCE(1)	13840593	20	20	20	7	1	3	10	4	2	0	0.85	1.00	1.00
409	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A4(2), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1)	11743641	8	8	8	4	1	1	3	1	2	0	0.89	1.00	1.00
410	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A4(2), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1)	11743641	8	8	8	4	1	1	3	1	2	0	0.89	1.00	1.00
411	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A4(2), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1)	11743641	8	8	8	4	1	1	3	1	2	0	0.89	1.00	1.00
412	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	ARSB(3), GALNS(1), GLB1(1), GUSB(1), HEXB(1), HGSNAT(3), HPSE(4), HPSE2(1), HYAL1(1), HYAL2(1), IDS(3), IDUA(2), LCT(6), MAN2B1(2), MAN2B2(3), MANBA(1), NAGLU(1), NEU2(1)	25434162	36	33	36	9	5	5	10	13	3	0	0.37	1.00	1.00
413	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), IMPDH1(2), POLB(1), POLG(1), PRPS2(1), RRM1(1)	9760764	8	8	8	4	1	1	5	0	1	0	0.87	1.00	1.00
414	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ACAA2(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), AKR1C4(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(1), SRD5A1(1), SRD5A2(3)	17706468	24	22	24	8	2	7	10	3	2	0	0.59	1.00	1.00
415	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	GRIN1(1), GRIN2A(10), GRIN2B(8), GRIN2C(5), GRIN2D(4), NOS1(3), PPP3CA(3), PPP3CB(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	19841952	40	38	39	11	9	4	18	5	4	0	0.30	1.00	1.00
416	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(2), ACPP(2), ACPT(2), ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), CYP1A2(1), CYP2A13(4), CYP2A6(1), CYP2A7(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2D6(2), CYP2F1(1), CYP3A4(3), CYP3A7(4), CYP4B1(3), CYP4F8(3), PON1(1)	22431708	48	39	47	11	10	8	15	8	7	0	0.13	1.00	1.00
417	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA3(1), ANXA4(1), ANXA6(2), CYP11A1(1), EDN1(2), EDNRA(1), EDNRB(1), HSD11B1(2), PLA2G4A(7), PTGDR(1), PTGDS(1), PTGFR(1), PTGIS(1), PTGS1(1), PTGS2(1), S100A6(1), TBXAS1(1)	15539043	26	24	25	8	3	5	12	5	1	0	0.58	1.00	1.00
418	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B1(3), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), DLAT(1), DLD(1), ENO1(1), ENO3(2), GCK(2), GPI(2), HK1(1), HK3(2), LDHC(1), PDHA1(2), PDHA2(2), PDHB(1), PFKM(4), PFKP(4), PGK1(2), PGM1(2), PGM3(1), PKLR(1), TPI1(2)	37323312	59	55	59	12	14	15	17	9	4	0	0.019	1.00	1.00
419	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B1(3), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), DLAT(1), DLD(1), ENO1(1), ENO3(2), GCK(2), GPI(2), HK1(1), HK3(2), LDHC(1), PDHA1(2), PDHA2(2), PDHB(1), PFKM(4), PFKP(4), PGK1(2), PGM1(2), PGM3(1), PKLR(1), TPI1(2)	37323312	59	55	59	12	14	15	17	9	4	0	0.019	1.00	1.00
420	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(2), AP2A1(4), AP2M1(3), BIN1(1), DNM1(2), EPS15(2), PPP3CA(3), PPP3CB(3), SYNJ2(1)	17506203	21	21	21	9	2	2	8	4	5	0	0.86	1.00	1.00
421	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), DRD2(1), GRM1(3), PLCB1(4), PPP2CA(1), PPP3CA(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1)	12191322	16	15	16	6	3	3	6	3	1	0	0.68	1.00	1.00
422	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(4), EXT2(2), EXTL3(3), GLCE(2), HS2ST1(2), HS3ST2(1), HS3ST5(3), HS6ST1(1), HS6ST2(3), HS6ST3(1), NDST3(1)	15655146	23	22	23	9	3	2	6	8	4	0	0.84	1.00	1.00
423	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(5), GABBR1(1), GPRC5A(1), GRM1(3), GRM2(1), GRM3(7), GRM4(1), GRM5(1), GRM8(1)	14653821	21	19	21	7	6	4	7	2	2	0	0.31	1.00	1.00
424	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(1), UCHL3(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2B15(3), UGT2B4(2)	13449189	14	14	14	7	1	1	5	5	2	0	0.87	1.00	1.00
425	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(12), CREB1(1), CREB3(1), DUSP10(1), EEF2K(3), ELK1(2), IL1R1(1), MAP2K3(1), MAP2K4(21), MAP3K10(4), MAP3K4(4), MAP3K5(2), MAP3K7(1), MAPK1(1), MAPK14(1), MKNK2(1), MYEF2(2), NFKB1(1), NR2C2(1), SRF(1), TRAF6(2)	25634427	64	59	52	17	7	19	14	6	18	0	0.32	1.00	1.00
426	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(1), BHMT(1), CBS(2), CTH(3), DNMT1(1), DNMT3A(3), DNMT3B(1), MAT1A(1), MAT2B(1), MTAP(1), MTR(5)	16007511	21	20	21	9	4	4	6	3	4	0	0.74	1.00	1.00
427	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(4), BCHE(2), CES1(2), CYP3A4(3), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2)	17328246	19	19	19	7	4	2	6	5	2	0	0.66	1.00	1.00
428	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ARPC1A(1), ARPC1B(1), ARPC2(2), NCK1(1), NCKAP1(3), NTRK1(3), PIR(1), WASF1(3), WASF3(1), WASL(1)	11829324	18	18	18	7	3	3	8	3	1	0	0.81	1.00	1.00
429	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(1), CYP1A2(1), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP3A4(3), CYP3A43(1), CYP3A7(4), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), RDH11(2), RDH12(1), RDH14(1)	18373680	38	35	36	10	4	9	9	8	8	0	0.24	1.00	1.00
430	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	GLB1(1), HEXB(1), LCT(6), MAN2B1(2), MAN2B2(3), MANBA(1), NEU2(1)	14313624	15	15	15	6	1	1	4	7	2	0	0.83	1.00	1.00
431	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	56	ASH1L(5), ASH2L(3), CARM1(1), CTCFL(2), DOT1L(4), EED(2), EHMT1(3), EZH1(1), EZH2(1), FBXO11(1), HCFC1(7), KDM6A(5), MEN1(2), MLL(6), MLL2(8), MLL3(38), MLL4(5), MLL5(4), OGT(2), PAXIP1(3), PRDM2(2), PRDM6(1), PRDM7(1), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), RBBP5(1), SATB1(2), SETD1B(1), SETD2(5), SETD7(1), SETD8(1), SETDB1(7), SETMAR(2), SMYD3(4), SUV420H1(2), SUZ12(3), WHSC1(7), WHSC1L1(1)	94554993	152	129	151	28	16	26	38	21	51	0	0.053	1.00	1.00
432	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(1), EPHB1(4), ITGA1(4), ITGB1(2), L1CAM(2), LYN(4), SELP(5)	12020970	23	23	23	9	6	6	8	3	0	0	0.65	1.00	1.00
433	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(3), AXIN1(1), BTRC(1), CAMK2A(1), CAMK2D(3), CAMK2G(1), CCND1(1), CCND3(3), CER1(1), CHD8(2), CREBBP(2), CSNK1A1L(3), CSNK1E(2), CSNK2A1(1), CSNK2A2(1), CTBP2(1), CUL1(1), DAAM1(1), DAAM2(3), DKK2(1), DKK4(1), DVL1(2), DVL3(1), EP300(3), FZD1(1), FZD3(3), FZD6(2), FZD7(1), FZD8(1), FZD9(1), JUN(1), LRP6(2), MAP3K7(1), MAPK10(1), MAPK8(2), MYC(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NKD1(1), NKD2(2), NLK(1), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PORCN(1), PPP2CA(1), PPP2CB(2), PPP3CA(3), PPP3CB(3), PRICKLE1(2), PRICKLE2(2), PRKACA(1), PRKCG(2), PRKX(1), PSEN1(1), RHOA(2), ROCK1(1), ROCK2(2), RUVBL1(1), SFRP1(3), SFRP4(1), SIAH1(3), SMAD2(3), SMAD3(2), SMAD4(1), TBL1X(4), TBL1XR1(8), TCF7(3), TCF7L2(2), TP53(189), VANGL1(2), VANGL2(3), WIF1(2), WNT10B(1), WNT11(2), WNT2(1), WNT2B(1), WNT3A(2), WNT5B(2), WNT6(1), WNT7A(6), WNT8B(1), WNT9A(1)	120101202	355	262	278	64	60	49	68	72	103	3	0.000024	1.00	1.00
434	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	MRPL13(1), MRPS7(2), RPL13A(2), RPL18(1), RPL18A(1), RPL19(1), RPL26(1), RPL29(1), RPL35(2), RPL3L(1), RPL41(1), RPL7(1), RPS10(1), RPS16(1), RPS2(1), RPS21(2), RPS27(1), RPS5(3), RPS6(2), RPSA(1)	17267406	27	26	27	7	2	5	12	6	2	0	0.44	1.00	1.00
435	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(2), EP300(3), IKBKB(3), MAP2K3(1), MAP3K7(1), MAPK14(1), NFKB1(1), NFKBIA(1), RELA(1), TGFBR1(2), TGFBR2(3), TLR2(1)	22611693	20	18	19	7	2	5	6	1	6	0	0.56	1.00	1.00
436	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(6), DYRK1B(1), GLI2(3), GLI3(4), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), SMO(2), SUFU(2)	11980410	21	18	21	9	5	5	8	2	1	0	0.67	1.00	1.00
437	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(2), HDAC3(2), NCOA1(1), NCOA2(1), NCOA3(6), NCOR2(3), POLR2A(2), RARA(1), TBP(1)	19566144	19	19	19	7	2	2	7	4	4	0	0.82	1.00	1.00
438	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(4), ALDOB(2), DLAT(1), DLD(1), ENO1(1), ENO3(2), GCK(2), GOT2(1), GPI(2), HK1(1), HK3(2), LDHC(1), MDH2(2), PC(3), PCK1(1), PDHA1(2), PDHA2(2), PDHB(1), PDHX(1), PFKM(4), PFKP(4), PGK1(2), PKLR(1), TPI1(2)	32638632	45	43	45	10	12	12	10	6	5	0	0.038	1.00	1.00
439	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(2), ALG6(1), CCKBR(1), CCR2(4), CCR3(1), CCR5(1), CELSR1(4), CELSR2(3), CELSR3(4), CHRM2(2), CHRM3(1), CXCR3(2), DRD4(1), EDNRA(1), EMR2(6), EMR3(2), F2R(2), FSHR(4), GHRHR(1), GPR116(2), GPR132(1), GPR133(2), GPR143(3), GPR17(1), GPR56(2), GPR77(2), GPR84(2), GRM1(3), GRPR(1), HRH4(1), LGR6(2), LPHN2(6), LPHN3(6), LTB4R2(1), OR8G2(1), P2RY11(1), P2RY13(2), PTGFR(1), SMO(2), SSTR2(1), TAAR5(3), TSHR(4)	50133174	93	80	93	21	18	22	21	21	11	0	0.0078	1.00	1.00
440	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(3), ACACB(8), ACAT1(1), ACSS1(1), ACYP1(1), AKR1B1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLAT(1), DLD(1), HAGHL(1), LDHC(1), MDH2(2), ME2(2), ME3(2), PC(3), PCK1(1), PCK2(1), PDHA1(2), PDHA2(2), PDHB(1), PKLR(1)	35460594	42	39	42	9	8	11	14	6	3	0	0.082	1.00	1.00
441	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2E2(1), GTF2F2(1), GTF2H1(1), GTF2H3(1), GTF2I(1), TAF1(8), TAF1L(7), TAF4B(2), TAF5L(2), TAF6(1), TAF7(1), TBPL2(2)	27078870	28	27	27	7	5	6	7	6	4	0	0.34	1.00	1.00
442	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(1), BID(4), CASP6(2), CASP8(3), DFFB(2), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(3), SPTAN1(2)	25418445	20	19	20	5	3	8	1	2	6	0	0.24	1.00	1.00
443	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), EGF(2), EGFR(5), GRB2(1), MET(5), PDGFRA(3), SH3KBP1(1)	14905800	18	16	18	8	4	3	4	4	3	0	0.88	1.00	1.00
444	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	68	B2M(2), CALR(1), CANX(1), CD4(2), CD74(1), CD8A(1), CIITA(3), CREB1(1), CTSB(1), CTSS(1), HLA-A(6), HLA-C(3), HLA-DMB(2), HLA-DQB1(2), HLA-DRB1(4), HLA-DRB5(1), HLA-E(2), HLA-F(2), HLA-G(2), HSP90AA1(2), HSP90AB1(2), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), KIR2DL1(2), KIR2DL3(2), KIR2DL4(1), KIR2DS4(1), KIR3DL2(4), KIR3DL3(1), KLRC1(3), KLRC2(1), KLRC3(1), LTA(1), NFYB(1), NFYC(1), RFXANK(1), TAP1(2)	29449095	74	60	73	21	8	17	24	9	16	0	0.36	1.00	1.00
445	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM10(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), EGFR(5), F11R(1), GIT1(1), IGSF5(3), IKBKB(3), JUN(1), LYN(4), MAP2K4(21), MAPK10(1), MAPK14(1), MAPK8(2), MET(5), NFKB1(1), NFKB2(3), NFKBIA(1), NOD1(3), PAK1(2), PLCG1(5), PLCG2(2), PTPN11(1), PTPRZ1(5), RELA(1), TCIRG1(1), TJP1(4)	54548130	90	82	89	20	11	15	27	7	29	1	0.19	1.00	1.00
446	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	BRAF(3), CPEB1(2), EGFR(5), ERBB2(8), ERBB4(6), ETS1(2), ETS2(4), ETV6(2), ETV7(1), FMN2(8), GRB2(1), KRAS(4), MAP2K1(1), MAPK1(1), MAPK3(1), NOTCH1(2), NOTCH2(7), NOTCH3(3), PIWIL1(8), PIWIL2(4), PIWIL3(2), PIWIL4(2), RAF1(1), SOS1(4), SOS2(2), SPIRE1(1)	37167663	85	75	82	22	12	21	24	19	9	0	0.13	1.00	1.00
447	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(4), DARS(1), EPRS(2), FARS2(1), GARS(1), IARS(6), LARS(1), LARS2(2), NARS(1), QARS(2), RARS(2), SARS(2), TARS(4), WARS2(1)	24255894	30	29	30	9	3	7	11	5	4	0	0.55	1.00	1.00
448	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(12), AKT2(1), AKT3(3), ASAH1(1), BRAF(3), DAG1(1), DRD2(1), EGFR(5), EPHB2(2), GRB2(1), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), KCNJ3(1), MAPK1(1), PI3(1), PIK3CB(4), PITX2(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), RAF1(1), RGS20(2), SHC1(1), SOS1(4), SOS2(2), STAT3(1), TERF2IP(2)	44704725	89	81	79	22	12	28	19	17	13	0	0.041	1.00	1.00
449	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(2), GAA(2), GALK2(1), GALT(1), GANAB(1), GCK(2), GLA(2), GLB1(1), HK1(1), HK3(2), LCT(6), MGAM(9), PFKM(4), PFKP(4), PGM1(2), PGM3(1)	25033632	43	39	43	12	12	5	8	13	5	0	0.23	1.00	1.00
450	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	CP(2), EPRS(2), GUSB(1), HMBS(1), PPOX(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2B15(3), UGT2B4(2)	20820969	17	16	17	9	2	2	7	4	2	0	0.93	1.00	1.00
451	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(12), AP2A1(4), AP2M1(3), ARF1(1), BAD(1), BTK(3), EEA1(3), GSK3A(1), LYN(4), PFKM(4), PFKP(4), PLCG1(5), PRKCE(1), PRKCZ(1), VAV2(1)	19715709	48	45	38	15	12	17	7	5	7	0	0.18	1.00	1.00
452	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN2(8), ACTN3(1), CAPN1(3), ITGA1(4), ITGB1(2), ITGB3(2), PTK2(3), PXN(1), SPTAN1(2), TLN1(9)	22364784	36	36	36	10	9	5	9	8	5	0	0.48	1.00	1.00
453	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(4), ALDOB(2), G6PD(1), GPI(2), H6PD(2), PFKM(4), PFKP(4), PGD(2), PGLS(2), PGM1(2), PGM3(1), PRPS2(1), TKT(1), TKTL1(1), TKTL2(1)	18335655	30	29	30	10	11	4	4	7	4	0	0.42	1.00	1.00
454	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(3), PGAP1(3), PIGA(1), PIGB(1), PIGG(1), PIGQ(3), PIGW(2)	19066749	15	14	15	8	2	3	5	4	1	0	0.88	1.00	1.00
455	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12(2), ALOX12B(1), ALOX5(1), CBR1(1), CBR3(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP4F2(1), DHRS4(1), GGT1(2), GPX5(2), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PTGDS(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(1)	30137601	44	42	42	11	6	9	16	6	7	0	0.13	1.00	1.00
456	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(4), B3GALT4(2), CDR1(1), DGKI(6), IL6ST(3), RPL13A(2), RPL17(1), RPL18(1), RPL18A(1), RPL19(1), RPL26(1), RPL29(1), RPL35(2), RPL36(1), RPL3L(1), RPL4(1), RPL41(1), RPL5(2), RPL7(1), RPLP2(1), RPS10(1), RPS14(1), RPS16(1), RPS2(1), RPS21(2), RPS27(1), RPS4X(1), RPS5(3), RPS6(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(3), RPS6KB2(4), RPSA(1), SLC36A2(1), TBC1D10C(2), UBC(7)	40286727	70	65	70	15	11	8	31	12	8	0	0.23	1.00	1.00
457	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), AGK(2), AGPAT3(2), AGPAT6(1), AKR1B1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CEL(1), DAK(3), DGAT1(1), DGAT2(1), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), DGKI(6), GK2(2), GLA(2), GLB1(1), GPAM(1), LCT(6), LIPA(1), LIPC(1), LIPG(1), LPL(1), PNLIP(2), PNLIPRP1(4), PNLIPRP2(1), PNPLA3(2), PPAP2A(1), PPAP2C(2)	45173700	71	63	70	19	15	14	21	10	10	1	0.19	1.00	1.00
458	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(1), BAD(1), CASP1(1), CASP2(3), CASP6(2), CASP8(3), CD40(1), CD40LG(1), DFFB(2), FAS(1), FASLG(1), IKBKE(1), LTA(1), NFKB1(1), NFKBIA(1), NGFR(1), NTRK1(3), PTPN13(4), RIPK1(3), SFRS2IP(2), TNFRSF1A(1), TRAF1(1), TRAF3(1), TRAF6(2)	32781606	39	37	39	10	4	17	7	4	7	0	0.12	1.00	1.00
459	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), DDX20(2), E2F1(2), E2F4(2), ETS1(2), ETS2(4), ETV3(2), HDAC2(3), HDAC5(2), JUN(1), NCOR2(3), RBL1(1), RBL2(1), SIN3A(3), SIN3B(2)	21072441	32	31	32	10	5	9	5	7	6	0	0.61	1.00	1.00
460	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(1), AOC3(2), AOX1(3), DBH(4), DCT(2), DDC(1), FAH(1), GOT2(1), GSTZ1(1), HGD(1), HPD(1), MAOA(2), MAOB(1), TPO(6), TYR(4)	24130665	45	43	45	15	9	6	18	6	6	0	0.58	1.00	1.00
461	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(1), ALDH1A3(3), ALDH1B1(1), ALDH3B1(3), ALDH3B2(2), ALDH9A1(1), AMDHD1(2), AOC2(1), AOC3(2), ASPA(2), CARM1(1), CNDP1(2), DDC(1), FTCD(1), HAL(2), LCMT1(1), LCMT2(5), MAOA(2), MAOB(1), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), PRPS2(1), WBSCR22(2)	30204525	50	42	50	15	7	11	20	4	8	0	0.30	1.00	1.00
462	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	34	ARSA(1), ARSE(2), ASAH1(1), B4GALT6(1), CERK(1), DEGS1(2), ENPP7(1), GAL3ST1(1), GLA(2), GLB1(1), LCT(6), NEU2(1), PPAP2A(1), PPAP2C(2), SGMS1(1), SGPP1(1), SGPP2(1), SMPD2(2), SMPD3(1), SPHK2(2), SPTLC1(1), SPTLC2(2), UGT8(1)	25688169	35	33	35	11	7	6	11	7	4	0	0.47	1.00	1.00
463	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(3), ACAT1(1), ACYP1(1), AKR1B1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLAT(1), DLD(1), HAGHL(1), LDHC(1), MDH2(2), ME2(2), ME3(2), PC(3), PCK1(1), PDHA1(2), PDHA2(2), PDHB(1), PKLR(1)	28015299	35	31	35	10	6	12	11	3	3	0	0.28	1.00	1.00
464	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(12), AKT2(1), AKT3(3), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PDK1(1), PHKA2(4), PIK3CB(4), PITX2(2), PLD1(1), PLD3(2)	34735584	63	55	53	17	8	23	11	10	10	1	0.093	1.00	1.00
465	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	48	ACHE(2), AGPAT3(2), AGPS(1), CDS1(2), CDS2(1), CHAT(1), CHKB(1), CLC(1), CPT1B(2), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), ETNK1(3), GNPAT(2), GPD1(2), GPD2(1), LCAT(1), LGALS13(1), PAFAH1B1(2), PCYT1A(1), PCYT1B(3), PLA2G2E(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLCB2(2), PLCG1(5), PLCG2(2), PPAP2A(1), PPAP2C(2)	38331228	68	62	65	18	11	12	21	16	8	0	0.23	1.00	1.00
466	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), ASCC3(2), ATP13A2(1), DDX23(1), DDX4(1), DDX41(2), DDX50(3), DDX51(1), DDX55(3), DDX56(1), DHX58(2), ENTPD7(3), EP400(2), ERCC3(2), FPGS(1), GCH1(1), IFIH1(1), MOV10L1(3), NUDT5(1), NUDT8(1), RAD54B(4), RAD54L(2), SETX(8), SKIV2L2(1), SMARCA2(4), SMARCA5(2)	48342957	61	52	60	14	12	11	19	10	9	0	0.14	1.00	1.00
467	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), B4GALT1(2), G6PC2(2), GAA(2), GALK2(1), GALT(1), GANC(1), GCK(2), GLA(2), GLB1(1), HK1(1), HK3(2), LCT(6), MGAM(9), PFKM(4), PFKP(4), PGM1(2), PGM3(1), RDH11(2), RDH12(1), RDH14(1)	29738085	49	46	49	15	12	6	8	17	6	0	0.30	1.00	1.00
468	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(5), ELK1(2), GNAS(5), GNB1(1), GRB2(1), IGF1R(2), ITGB1(2), KLK2(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MKNK2(1), MYC(1), NGFR(1), PDGFRA(3), PPP2CA(1), PTPRR(2), RAF1(1), RPS6KA1(1), RPS6KA5(1), SHC1(1), SOS1(4), STAT3(1)	25173057	42	41	42	12	10	12	9	8	3	0	0.26	1.00	1.00
469	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(8), CARM1(1), CCND1(1), CREBBP(2), EP300(3), ERCC3(2), ESR1(2), GRIP1(1), HDAC1(2), HDAC2(3), HDAC3(2), HDAC4(1), HDAC5(2), HDAC6(3), MEF2C(2), NCOR2(3), NRIP1(1), PELP1(2), POLR2A(2), TBP(1)	36497916	44	41	43	12	3	12	11	4	14	0	0.36	1.00	1.00
470	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACYP1(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH3B1(3), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), DLAT(1), DLD(1), ENO1(1), ENO3(2), G6PC2(2), GCK(2), GPI(2), HK1(1), HK3(2), LDHC(1), PDHA1(2), PDHA2(2), PDHB(1), PFKM(4), PFKP(4), PGAM4(1), PGK1(2), PGM1(2), PGM3(1), PKLR(1), TPI1(2)	44603832	60	55	60	16	15	14	16	11	4	0	0.091	1.00	1.00
471	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), ALDOA(4), ALDOB(2), FUK(2), GMDS(2), HK1(1), HK3(2), KHK(1), MTMR2(1), MTMR6(1), PFKFB1(1), PFKFB3(1), PFKFB4(1), PFKM(4), PFKP(4), RDH11(2), RDH12(1), RDH14(1), SORD(1), TPI1(2), TSTA3(1)	29216382	37	35	37	11	10	8	6	6	7	0	0.24	1.00	1.00
472	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(2), BRAF(3), CREB1(1), ELK1(2), GRB2(1), IKBKB(3), JUN(1), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K4(21), MAP2K5(2), MAP2K7(1), MAP3K1(47), MAP3K10(4), MAP3K11(1), MAP3K12(2), MAP3K13(5), MAP3K4(4), MAP3K5(2), MAP3K6(1), MAP3K7(1), MAP3K8(2), MAP3K9(3), MAP4K1(3), MAP4K4(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK4(4), MAPK6(1), MAPK8(2), MAPKAPK3(1), MAX(2), MEF2A(1), MEF2C(2), MKNK2(1), MYC(1), NFKB1(1), NFKBIA(1), PAK1(2), PAK2(1), RAF1(1), RELA(1), RIPK1(3), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), RPS6KA5(1), RPS6KB2(4), SHC1(1), SP1(2), STAT1(1), TGFB3(1), TGFBR1(2)	74643075	163	134	160	31	22	19	31	15	61	15	0.14	1.00	1.00
473	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(4), AARS2(3), CARS2(2), DARS(1), DARS2(1), EARS2(3), EPRS(2), FARS2(1), FARSA(1), FARSB(3), GARS(1), IARS(6), IARS2(2), LARS(1), LARS2(2), NARS(1), NARS2(2), PARS2(1), QARS(2), RARS(2), RARS2(2), SARS(2), SARS2(2), TARS(4), TARS2(5), WARS2(1)	39107952	57	53	57	14	11	12	22	7	5	0	0.23	1.00	1.00
474	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(5), COL4A2(4), COL4A3(2), COL4A4(2), COL4A5(4), COL4A6(4), F12(1), F2(3), F2R(2), F5(11), F8(1), F9(1), FGA(3), FGG(1), KLKB1(1), PROC(1), PROS1(1), SERPINC1(3)	34709727	50	46	50	15	8	12	17	9	4	0	0.42	1.00	1.00
475	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(2), ACTG1(1), ACTN2(8), ACTN3(1), ACTN4(4), AKT1(12), AKT2(1), AKT3(3), ARHGAP5(3), BAD(1), BRAF(3), CAPN2(2), CAV1(1), CCND1(1), CCND3(3), COL11A1(2), COL11A2(1), COL1A1(7), COL1A2(5), COL2A1(4), COL3A1(1), COL4A1(5), COL4A2(4), COL4A4(2), COL4A6(4), COL5A1(2), COL5A2(5), COL5A3(4), COL6A1(1), COL6A2(3), COL6A3(7), COL6A6(6), COMP(3), CRKL(1), EGF(2), EGFR(5), ELK1(2), ERBB2(8), FARP2(5), FIGF(2), FLNA(5), FLNB(8), FLNC(9), FLT1(2), FN1(3), GRB2(1), GRLF1(5), HGF(3), IGF1(1), IGF1R(2), ILK(2), ITGA1(4), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(2), ITGA4(1), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGA9(2), ITGAV(5), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(1), ITGB8(2), JUN(1), KDR(2), LAMA1(7), LAMA2(9), LAMA3(8), LAMA4(4), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(4), LAMB4(7), LAMC1(3), LAMC2(1), LAMC3(1), MAP2K1(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MET(5), MYL7(1), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PARVA(1), PDGFB(1), PDGFRA(3), PDGFRB(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PIP5K1C(4), PPP1R12A(2), PRKCG(2), PTEN(17), PTK2(3), PXN(1), RAF1(1), RAPGEF1(3), RELN(13), RHOA(2), ROCK1(1), ROCK2(2), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(2), SPP1(2), THBS1(4), THBS2(1), THBS3(2), THBS4(1), TLN1(9), TLN2(5), TNC(5), TNN(5), TNR(2), TNXB(5), VAV1(2), VAV2(1), VAV3(1), VCL(3), VWF(8)	283867779	657	366	480	171	91	160	126	179	99	2	0.0015	1.00	1.00
476	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	246	ACVR1B(5), ACVR1C(1), AKT1(12), AKT2(1), AKT3(3), ARRB1(1), ARRB2(1), ATF2(2), ATF4(1), BDNF(1), BRAF(3), CACNA1A(6), CACNA1B(8), CACNA1C(6), CACNA1D(5), CACNA1E(13), CACNA1F(8), CACNA1G(5), CACNA1H(4), CACNA1I(2), CACNA1S(2), CACNA2D1(4), CACNA2D2(4), CACNA2D3(5), CACNA2D4(1), CACNB1(1), CACNB2(2), CACNG1(1), CACNG2(1), CACNG3(3), CACNG4(2), CACNG5(1), CACNG6(1), CACNG8(1), CD14(1), CDC25B(3), CRKL(1), DUSP10(1), DUSP16(3), DUSP4(1), DUSP6(1), DUSP7(1), DUSP9(1), EGF(2), EGFR(5), ELK1(2), FAS(1), FASLG(1), FGF10(1), FGF11(1), FGF13(2), FGF18(2), FGF21(1), FGF23(2), FGF3(1), FGF5(1), FGF6(1), FGF7(2), FGF9(1), FGFR2(4), FGFR3(1), FGFR4(3), FLNA(5), FLNB(8), FLNC(9), GRB2(1), IKBKB(3), IL1A(1), IL1R1(1), IL1R2(4), JUN(1), KRAS(4), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K4(21), MAP2K5(2), MAP2K7(1), MAP3K1(47), MAP3K10(4), MAP3K12(2), MAP3K13(5), MAP3K4(4), MAP3K5(2), MAP3K6(1), MAP3K7(1), MAP3K8(2), MAP4K1(3), MAP4K4(1), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(4), MAPKAPK3(1), MAPT(1), MAX(2), MEF2C(2), MKNK2(1), MOS(2), MYC(1), NF1(15), NFATC2(1), NFATC4(4), NFKB1(1), NFKB2(3), NLK(1), NR4A1(1), NTRK1(3), NTRK2(3), PAK1(2), PAK2(1), PDGFB(1), PDGFRA(3), PDGFRB(2), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PPM1B(1), PPP3CA(3), PPP3CB(3), PRKACA(1), PRKCG(2), PRKX(1), PTPN5(3), PTPN7(2), PTPRR(2), RAF1(1), RAPGEF2(1), RASA1(2), RASA2(2), RASGRF1(4), RASGRP2(2), RASGRP4(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA4(1), RPS6KA5(1), RPS6KA6(3), SOS1(4), SOS2(2), SRF(1), STK3(1), STK4(2), TAOK1(2), TAOK2(1), TAOK3(3), TGFB3(1), TGFBR1(2), TGFBR2(3), TNFRSF1A(1), TP53(189), TRAF6(2), ZAK(1)	225555681	636	347	543	133	114	93	129	107	176	17	0.000019	1.00	1.00
477	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ACTN2(8), ACTN3(1), ACTN4(4), APC(3), ARAF(1), ARHGEF1(5), ARHGEF12(2), ARHGEF4(3), ARHGEF6(1), ARHGEF7(2), ARPC1A(1), ARPC1B(1), ARPC2(2), BAIAP2(2), BDKRB1(2), BDKRB2(1), BRAF(3), C3orf10(1), CD14(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CRKL(1), CYFIP1(1), CYFIP2(5), DIAPH2(1), DIAPH3(1), EGF(2), EGFR(5), EZR(2), F2(3), F2R(2), FGD3(3), FGF10(1), FGF11(1), FGF13(2), FGF18(2), FGF21(1), FGF23(2), FGF3(1), FGF5(1), FGF6(1), FGF7(2), FGF9(1), FGFR2(4), FGFR3(1), FGFR4(3), FN1(3), GIT1(1), GRLF1(5), GSN(1), IQGAP1(1), IQGAP2(2), IQGAP3(4), ITGA1(4), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(2), ITGA4(1), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGA9(2), ITGAD(1), ITGAE(1), ITGAL(1), ITGAM(1), ITGAV(5), ITGAX(4), ITGB1(2), ITGB2(3), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(1), ITGB8(2), KRAS(4), LIMK1(3), LIMK2(1), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MOS(2), MSN(1), MYH10(7), MYH14(8), MYH9(5), MYL7(1), MYLK(6), MYLK2(1), NCKAP1(3), NCKAP1L(4), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PDGFB(1), PDGFRA(3), PDGFRB(2), PIK3CA(194), PIK3CB(4), PIK3CG(2), PIK3R1(14), PIK3R3(1), PIP4K2A(1), PIP4K2C(5), PIP5K1A(1), PIP5K1C(4), PPP1R12A(2), PTK2(3), PXN(1), RAF1(1), RDX(1), RHOA(2), ROCK1(1), ROCK2(2), SCIN(2), SOS1(4), SOS2(2), SSH1(1), SSH2(1), SSH3(2), TIAM1(1), TIAM2(5), VAV1(2), VAV2(1), VAV3(1), VCL(3), WAS(2), WASF1(3), WASL(1)	215264088	509	320	343	122	63	120	98	164	64	0	0.00052	1.00	1.00
478	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(3), ADCY3(2), ADCY4(2), ADCY7(4), ADCY8(4), ADCY9(5), ADRA1A(2), ADRA1B(1), ATP2A1(2), ATP2A2(1), ATP2A3(1), ATP2B1(4), ATP2B2(2), ATP2B3(6), ATP2B4(1), AVPR1B(1), BDKRB1(2), BDKRB2(1), CACNA1A(6), CACNA1B(8), CACNA1C(6), CACNA1D(5), CACNA1E(13), CACNA1F(8), CACNA1G(5), CACNA1H(4), CACNA1I(2), CACNA1S(2), CAMK2A(1), CAMK2D(3), CAMK2G(1), CCKBR(1), CD38(2), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CYSLTR1(2), CYSLTR2(1), EDNRA(1), EDNRB(1), EGFR(5), ERBB2(8), ERBB3(9), ERBB4(6), F2R(2), GNAQ(1), GNAS(5), GRIN1(1), GRIN2A(10), GRIN2C(5), GRIN2D(4), GRM1(3), GRM5(1), GRPR(1), HRH1(1), HRH2(2), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(4), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), LHCGR(4), LTB4R2(1), MYLK(6), MYLK2(1), NOS1(3), NOS3(2), P2RX2(2), P2RX3(1), P2RX4(2), P2RX5(1), P2RX7(1), PDE1A(2), PDE1B(2), PDE1C(1), PDGFRA(3), PDGFRB(2), PHKA1(1), PHKA2(4), PHKB(2), PHKG2(1), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLCD1(1), PLCD3(3), PLCE1(7), PLCG1(5), PLCG2(2), PLCZ1(3), PPID(1), PPP3CA(3), PPP3CB(3), PRKACA(1), PRKCG(2), PRKX(1), PTGER3(3), PTGFR(1), PTK2B(3), RYR1(11), RYR2(24), RYR3(13), SLC25A4(1), SLC8A1(1), SLC8A3(1), SPHK2(2), TACR2(1), TNNC2(1), TRPC1(3), VDAC2(2)	211650192	374	233	371	167	104	53	109	72	35	1	0.98	1.00	1.00
479	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(2), ACTG1(1), COL11A1(2), COL11A2(1), COL17A1(5), COL1A1(7), COL1A2(5), COL2A1(4), COL3A1(1), COL4A1(5), COL4A2(4), COL4A4(2), COL4A6(4), COL5A1(2), COL5A2(5), COL5A3(4), COL6A1(1), COL6A2(3), COL6A3(7), COL6A6(6), COMP(3), DSC2(4), DSC3(1), DSG1(2), DSG3(4), DSG4(2), FN1(3), GJA1(2), GJA10(1), GJA4(1), GJA5(1), GJA8(1), GJA9(1), GJB2(1), GJB3(2), GJB4(1), GJB5(1), GJC1(1), INA(1), ITGA6(3), ITGB4(4), KRT1(4), KRT14(2), KRT15(1), KRT17(5), KRT18(1), KRT19(2), KRT2(2), KRT25(2), KRT28(3), KRT3(1), KRT33A(1), KRT34(1), KRT35(1), KRT36(2), KRT37(1), KRT38(3), KRT39(1), KRT4(2), KRT6A(1), KRT6C(1), KRT71(1), KRT72(2), KRT73(1), KRT79(1), KRT81(2), KRT82(2), KRT83(1), KRT84(1), KRT85(1), KRT86(1), KRT9(2), LAMA1(7), LAMA2(9), LAMA3(8), LAMA4(4), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(4), LAMB4(7), LAMC1(3), LAMC2(1), LAMC3(1), LMNB1(1), NES(3), RELN(13), SPP1(2), THBS1(4), THBS2(1), THBS3(2), THBS4(1), TNC(5), TNN(5), TNR(2), TNXB(5), VIM(1), VWF(8)	188549244	278	203	275	117	61	55	77	38	47	0	0.94	1.00	1.00
480	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	237	ADCYAP1R1(1), ADORA1(1), ADORA3(2), ADRA1A(2), ADRA1B(1), ADRA2B(1), AVPR1B(1), BDKRB1(2), BDKRB2(1), BRS3(2), C3AR1(1), CALCR(1), CALCRL(2), CCKBR(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CNR1(1), CNR2(1), CRHR1(3), CRHR2(1), CTSG(1), CYSLTR1(2), CYSLTR2(1), DRD2(1), DRD3(1), DRD4(1), EDNRA(1), EDNRB(1), F2(3), F2R(2), F2RL2(1), FPR1(1), FSHR(4), GABBR1(1), GABBR2(1), GABRA1(2), GABRA3(3), GABRA5(1), GABRA6(3), GABRB1(1), GABRB2(2), GABRB3(1), GABRE(1), GABRG1(2), GABRG2(2), GABRG3(2), GABRQ(3), GABRR1(1), GALR1(2), GALR2(1), GH2(2), GHR(2), GHRHR(1), GHSR(1), GIPR(1), GLRA2(1), GLRA3(1), GPR156(2), GPR35(1), GPR50(2), GPR63(1), GPR83(3), GRIA1(6), GRIA2(1), GRIA3(6), GRIA4(3), GRID1(7), GRID2(3), GRIK1(5), GRIK2(8), GRIK3(4), GRIK4(1), GRIK5(3), GRIN1(1), GRIN2A(10), GRIN2B(8), GRIN2C(5), GRIN2D(4), GRIN3A(4), GRIN3B(2), GRM1(3), GRM2(1), GRM3(7), GRM4(1), GRM5(1), GRM6(1), GRM8(1), GRPR(1), GZMA(1), HCRTR1(2), HCRTR2(1), HRH1(1), HRH2(2), HRH3(2), HRH4(1), HTR1A(1), HTR1B(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(4), LEPR(3), LHB(2), LHCGR(4), LTB4R2(1), MAS1(2), MC2R(1), MC3R(2), MC4R(1), MCHR2(1), NMUR1(1), NMUR2(2), NPBWR2(1), NPFFR2(3), NPY1R(3), NPY2R(1), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(5), P2RX2(2), P2RX3(1), P2RX4(2), P2RX5(1), P2RX7(1), P2RY1(2), P2RY10(1), P2RY11(1), P2RY13(2), P2RY2(1), P2RY4(2), P2RY6(1), P2RY8(1), PARD3(3), PPYR1(1), PRLR(1), PTGDR(1), PTGER3(3), PTGFR(1), PTH2R(2), RXFP1(3), SSTR2(1), SSTR3(2), SSTR5(1), TAAR1(1), TAAR2(1), TAAR5(3), TAAR6(1), TACR2(1), THRA(1), THRB(1), TSHR(4), TSPO(1), UTS2R(1), VIPR1(1)	165953775	314	199	312	110	81	42	107	54	29	1	0.27	1.00	1.00
481	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(2), ACTG1(1), ACTN2(8), ACTN3(1), ACTN4(4), AKT1(12), AKT2(1), AKT3(3), AMOTL1(2), ASH1L(5), CASK(4), CGN(1), CLDN11(1), CLDN15(1), CLDN17(1), CLDN19(1), CLDN5(1), CLDN6(2), CRB3(1), CSNK2A1(1), CSNK2A2(1), CTNNA1(2), CTNNA2(4), CTNNA3(4), CTTN(1), EPB41(1), EPB41L1(4), EPB41L2(2), EPB41L3(3), EXOC3(2), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), HCLS1(1), IGSF5(3), INADL(5), KRAS(4), LLGL1(1), LLGL2(5), MAGI1(3), MAGI2(7), MAGI3(4), MLLT4(9), MPDZ(6), MYH1(5), MYH10(7), MYH11(7), MYH13(4), MYH14(8), MYH15(5), MYH2(2), MYH3(1), MYH4(6), MYH6(7), MYH7(9), MYH7B(7), MYH8(5), MYH9(5), MYL7(1), PARD3(3), PARD6B(1), PPP2CA(1), PPP2CB(2), PPP2R3A(3), PPP2R4(3), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(1), PTEN(17), RAB13(1), RHOA(2), SPTAN1(2), SYMPK(5), TJP1(4), TJP3(2), VAPA(1), YES1(2), ZAK(1)	149729268	268	193	255	92	50	45	83	35	53	2	0.84	1.00	1.00
482	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), ADRA1A(2), ADRA1B(1), ANXA6(2), ARRB1(1), ARRB2(1), ATP1A4(9), ATP1B1(1), ATP1B3(1), ATP2A2(1), ATP2A3(1), ATP2B1(4), ATP2B2(2), ATP2B3(6), CACNA1A(6), CACNA1B(8), CACNA1C(6), CACNA1D(5), CACNA1E(13), CACNA1S(2), CACNB1(1), CALR(1), CAMK1(2), CAMK2A(1), CAMK2D(3), CAMK2G(1), CASQ1(2), CASQ2(2), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), GJA1(2), GJA4(1), GJA5(1), GJB2(1), GJB3(2), GJB4(1), GJB5(1), GNAI2(1), GNAO1(1), GNAQ(1), GNB1(1), GNB3(3), GRK4(3), GRK6(1), ITPR1(8), ITPR2(3), ITPR3(4), KCNB1(2), KCNJ3(1), MIB1(4), NME7(3), PKIG(1), PLCB3(1), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(3), PRKCZ(1), PRKD1(2), RGS1(1), RGS11(1), RGS14(1), RGS17(2), RGS20(2), RGS3(3), RGS4(4), RGS5(1), RGS7(5), RGS9(4), RYR1(11), RYR2(24), RYR3(13), SLC8A1(1), SLC8A3(1), USP5(4), YWHAB(1)	148069857	258	181	258	116	74	35	73	47	28	1	0.95	1.00	1.00
483	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	84	CD36(1), COL11A1(2), COL11A2(1), COL1A1(7), COL1A2(5), COL2A1(4), COL3A1(1), COL4A1(5), COL4A2(4), COL4A4(2), COL4A6(4), COL5A1(2), COL5A2(5), COL5A3(4), COL6A1(1), COL6A2(3), COL6A3(7), COL6A6(6), DAG1(1), FN1(3), FNDC1(6), FNDC3A(1), GP6(1), HSPG2(9), ITGA1(4), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(2), ITGA4(1), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGA9(2), ITGAV(5), ITGB1(2), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(1), ITGB8(2), LAMA1(7), LAMA2(9), LAMA3(8), LAMA4(4), LAMA5(7), LAMB1(6), LAMB2(5), LAMB3(4), LAMB4(7), LAMC1(3), LAMC2(1), LAMC3(1), RELN(13), SDC4(1), SPP1(2), SV2A(1), SV2B(1), THBS1(4), THBS2(1), THBS3(2), THBS4(1), TNC(5), TNN(5), TNR(2), TNXB(5), VWF(8)	171055209	246	179	245	111	53	52	65	39	37	0	0.99	1.00	1.00
484	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(4), ABLIM1(1), ABLIM3(2), ARHGEF12(2), CDK5(1), DCC(7), DPYSL2(2), DPYSL5(2), EFNA3(1), EFNB1(1), EFNB2(1), EPHA1(2), EPHA2(2), EPHA3(2), EPHA4(1), EPHA5(6), EPHA6(2), EPHA7(3), EPHA8(1), EPHB1(4), EPHB2(2), EPHB3(2), EPHB4(2), EPHB6(2), FES(2), GNAI1(1), GNAI2(1), ITGB1(2), KRAS(4), L1CAM(2), LIMK1(3), LIMK2(1), LRRC4C(1), MAPK1(1), MAPK3(1), MET(5), NCK1(1), NCK2(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NGEF(2), NRP1(5), NTNG1(2), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PLXNA1(5), PLXNA2(6), PLXNA3(3), PLXNB1(1), PLXNB2(3), PLXNB3(1), PLXNC1(2), PPP3CA(3), PPP3CB(3), PTK2(3), RASA1(2), RGS3(3), RHOA(2), RND1(1), ROBO1(4), ROBO2(4), ROBO3(1), ROCK1(1), ROCK2(2), SEMA3A(2), SEMA3B(1), SEMA3C(2), SEMA3D(2), SEMA3E(1), SEMA3F(1), SEMA4A(2), SEMA4B(1), SEMA4D(1), SEMA4F(5), SEMA4G(3), SEMA5A(8), SEMA5B(3), SEMA6A(1), SEMA6C(1), SEMA6D(2), SEMA7A(1), SLIT1(1), SLIT2(3), SLIT3(2), SRGAP1(8), SRGAP3(1), UNC5B(1), UNC5C(5), UNC5D(9)	150736677	226	172	225	77	47	38	73	30	38	0	0.56	1.00	1.00
485	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), ATF4(1), CACNA1C(6), CACNA1D(5), CACNA1F(8), CACNA1S(2), CAMK2A(1), CAMK2D(3), CAMK2G(1), EGFR(5), ELK1(2), GNAQ(1), GNAS(5), GNRH2(1), GRB2(1), ITPR1(8), ITPR2(3), ITPR3(4), JUN(1), KRAS(4), LHB(2), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAP2K4(21), MAP2K7(1), MAP3K1(47), MAP3K4(4), MAPK1(1), MAPK10(1), MAPK14(1), MAPK3(1), MAPK8(2), MMP14(3), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PLD1(1), PRKACA(1), PRKX(1), PTK2B(3), RAF1(1), SOS1(4), SOS2(2)	99865818	217	167	210	69	37	27	46	32	60	15	0.78	1.00	1.00
486	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ACTA1(1), ACTA2(1), ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), ARRB1(1), ARRB2(1), ATF2(2), ATF3(1), ATF4(1), ATF5(2), ATP2A2(1), ATP2A3(1), CALCA(1), CAMK2A(1), CAMK2D(3), CAMK2G(1), CNN1(1), CNN2(1), CORIN(2), CREB3(1), CRHR1(3), ETS2(4), GABPA(1), GJA1(2), GNAQ(1), GNB1(1), GNB3(3), GRK4(3), GRK6(1), IGFBP3(1), IL6(2), ITPR1(8), ITPR2(3), ITPR3(4), JUN(1), MIB1(4), MYLK2(1), NFKB1(1), NOS1(3), NOS3(2), PDE4B(2), PDE4D(6), PKIG(1), PLCB3(1), PLCD1(1), PLCG1(5), PLCG2(2), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCE(1), PRKCH(1), PRKCQ(3), PRKCZ(1), PRKD1(2), RAMP3(1), RGS1(1), RGS11(1), RGS14(1), RGS17(2), RGS20(2), RGS3(3), RGS4(4), RGS5(1), RGS7(5), RGS9(4), RLN1(1), RYR1(11), RYR2(24), RYR3(13), SLC8A1(1), SP1(2), TNXB(5), USP5(4), YWHAB(1)	132315339	215	163	215	91	60	28	64	36	27	0	0.91	1.00	1.00
487	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	125	ALCAM(2), CADM1(1), CD2(2), CD22(2), CD226(2), CD274(1), CD276(1), CD34(1), CD4(2), CD40(1), CD40LG(1), CD86(2), CD8A(1), CD99(2), CDH1(33), CDH15(2), CDH2(1), CDH4(3), CLDN11(1), CLDN15(1), CLDN17(1), CLDN19(1), CLDN5(1), CLDN6(2), CNTN1(5), CNTN2(4), CNTNAP1(3), CNTNAP2(3), CTLA4(1), ESAM(2), F11R(1), GLG1(2), HLA-A(6), HLA-C(3), HLA-DMB(2), HLA-DQB1(2), HLA-DRB1(4), HLA-DRB5(1), HLA-E(2), HLA-F(2), HLA-G(2), ICOS(1), ICOSLG(1), ITGA4(1), ITGA6(3), ITGA8(2), ITGA9(2), ITGAL(1), ITGAM(1), ITGAV(5), ITGB1(2), ITGB2(3), ITGB8(2), L1CAM(2), MADCAM1(1), MAG(1), MPZL1(1), NCAM1(4), NCAM2(2), NEO1(4), NFASC(6), NLGN1(1), NLGN2(2), NLGN3(4), NRCAM(2), NRXN1(4), NRXN2(5), NRXN3(7), PDCD1(1), PTPRC(1), PTPRF(5), PTPRM(3), PVRL1(1), PVRL2(3), PVRL3(3), SDC4(1), SELE(1), SELL(4), SELP(5), SELPLG(1), SIGLEC1(1), SPN(2), VCAM1(2), VCAN(10)	108551742	226	162	221	62	36	38	59	32	61	0	0.098	1.00	1.00
488	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1(1), ACVR1B(5), ACVR2A(3), AMHR2(2), BMP2(3), BMPR1B(2), BMPR2(2), CCL11(1), CCL13(1), CCL21(1), CCL23(1), CCL7(1), CCR1(1), CCR2(4), CCR3(1), CCR5(1), CCR7(2), CD40(1), CD40LG(1), CNTFR(1), CSF1(2), CSF2RA(2), CSF2RB(2), CSF3R(2), CX3CL1(1), CX3CR1(2), CXCL6(1), CXCR3(2), EDA(2), EDA2R(1), EDAR(1), EGF(2), EGFR(5), EPOR(2), FAS(1), FASLG(1), FLT1(2), FLT3(3), FLT3LG(1), FLT4(1), GDF5(1), GH2(2), GHR(2), HGF(3), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA2(2), IFNA4(1), IFNA7(1), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNK(1), IL10RA(1), IL10RB(3), IL11RA(2), IL12A(1), IL12B(1), IL12RB1(3), IL13RA1(1), IL15(1), IL17B(2), IL17RA(2), IL17RB(3), IL18R1(1), IL18RAP(3), IL1A(1), IL1R1(1), IL1R2(4), IL1RAP(2), IL2(1), IL21(1), IL21R(1), IL22(1), IL22RA1(1), IL22RA2(1), IL23R(3), IL25(1), IL28A(1), IL28B(3), IL28RA(1), IL2RB(1), IL2RG(1), IL3RA(1), IL4R(1), IL5RA(1), IL6(2), IL6R(1), IL6ST(3), IL7R(1), INHBA(1), INHBC(1), INHBE(1), KDR(2), KIT(5), KITLG(2), LEPR(3), LIF(3), LIFR(4), LTA(1), MET(5), NGFR(1), OSMR(4), PDGFB(1), PDGFRA(3), PDGFRB(2), PF4(1), PLEKHO2(1), PRLR(1), TGFB3(1), TGFBR1(2), TGFBR2(3), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(2), TNFRSF19(1), TNFRSF1A(1), TNFRSF21(2), TNFRSF8(1), TNFSF13B(1), TNFSF14(1), TNFSF18(1), TNFSF4(1), TPO(6), TSLP(1), XCR1(2)	134607993	223	160	221	70	37	46	66	34	40	0	0.20	1.00	1.00
489	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTA2(1), ACTN2(8), ACTN3(1), ACTN4(4), DMD(15), MYBPC1(2), MYBPC2(3), MYBPC3(1), MYH3(1), MYH6(7), MYH7(9), MYH8(5), MYL1(1), MYOM1(3), NEB(19), TMOD1(1), TNNC2(1), TNNI3(1), TNNT1(1), TNNT3(2), TPM1(3), TPM2(1), TPM3(2), TTN(102), VIM(1)	108532983	196	144	196	34	32	22	68	44	29	1	0.0041	1.00	1.00
490	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTB(2), ACTG1(1), ACTN2(8), ACTN3(1), ACTN4(4), ACVR1B(5), ACVR1C(1), BAIAP2(2), CDH1(33), CREBBP(2), CSNK2A1(1), CSNK2A2(1), CTNNA1(2), CTNNA2(4), CTNNA3(4), CTNND1(1), EGFR(5), EP300(3), ERBB2(8), FARP2(5), IGF1R(2), INSR(2), IQGAP1(1), LMO7(1), MAP3K7(1), MAPK1(1), MAPK3(1), MET(5), MLLT4(9), NLK(1), PARD3(3), PTPRB(5), PTPRF(5), PTPRJ(1), PTPRM(3), PVRL1(1), PVRL2(3), PVRL3(3), RHOA(2), SMAD2(3), SMAD3(2), SMAD4(1), SNAI1(2), SNAI2(1), SORBS1(4), SSX2IP(1), TCF7(3), TCF7L2(2), TGFBR1(2), TGFBR2(3), TJP1(4), VCL(3), WAS(2), WASF1(3), WASF3(1), WASL(1), YES1(2)	92210625	183	139	177	54	31	25	48	13	66	0	0.67	1.00	1.00
491	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADA(2), ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), ADK(1), ADSL(2), AK2(1), AK3L1(1), AK5(2), AK7(2), AMPD1(6), ATIC(3), DGUOK(1), ENPP1(4), ENPP3(2), ENTPD1(2), ENTPD2(2), ENTPD4(2), ENTPD6(1), FHIT(1), GMPR2(1), GMPS(1), GUCY1A2(3), GUCY2C(5), GUCY2D(1), GUCY2F(2), IMPDH1(2), IMPDH2(1), NME6(1), NME7(3), NPR1(2), NPR2(2), NT5C1B(4), NT5C3(1), NT5E(3), NUDT5(1), PAICS(1), PAPSS1(2), PDE10A(1), PDE11A(3), PDE1A(2), PDE1C(1), PDE2A(3), PDE3B(1), PDE4A(1), PDE4B(2), PDE4C(4), PDE4D(6), PDE5A(1), PDE6G(1), PDE8A(1), PDE9A(3), PFAS(1), PKLR(1), POLA1(4), POLD2(1), POLD4(1), POLE(5), POLE2(1), POLE3(1), POLR1A(2), POLR1B(2), POLR1C(2), POLR1D(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), POLR3A(1), POLR3B(3), POLR3GL(2), PPAT(1), PRPS2(1), PRUNE(3), RRM1(1), RRM2(1), XDH(3)	125975304	174	133	173	66	35	26	59	30	24	0	0.84	1.00	1.00
492	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(2), BAD(1), CABIN1(5), CD3E(1), CD3G(1), CD69(2), CNR1(1), CREBBP(2), CSNK2A1(1), CTLA4(1), EGR2(1), EGR3(3), EP300(3), FCER1A(2), GATA3(56), GRLF1(5), GSK3A(1), ICOS(1), IFNA1(1), IFNB1(1), IL2(1), IL6(2), ITK(4), KPNA5(1), MAP2K7(1), MAPK14(1), MAPK8(2), MEF2A(1), NCK2(1), NFAT5(3), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NFKB2(3), NFKBIE(1), NUP214(5), OPRD1(2), P2RX7(1), PAK1(2), PPP3CB(3), PTPRC(1), RELA(1), RPL13A(2), SP1(2), SP3(3), TRPV6(2), VAV1(2), VAV2(1), VAV3(1), XPO5(2)	69120831	151	131	128	43	12	20	25	16	76	2	0.96	1.00	1.00
493	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	159	ADORA1(1), ADORA3(2), ADRA1A(2), ADRA1B(1), AVPR1B(1), BDKRB1(2), BDKRB2(1), BRS3(2), C3AR1(1), CCKBR(1), CCR1(1), CCR10(1), CCR2(4), CCR3(1), CCR5(1), CCR7(2), CCRL1(1), CHML(2), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(1), CX3CR1(2), CXCR3(2), DRD2(1), DRD3(1), DRD4(1), EDNRA(1), EDNRB(1), F2R(2), F2RL2(1), FPR1(1), FSHR(4), GALR1(2), GALR2(1), GALT(1), GHSR(1), GNB2L1(1), GPR17(1), GPR174(2), GPR35(1), GPR37(2), GPR50(2), GPR6(2), GPR63(1), GPR77(2), GPR83(3), GPR85(1), GRPR(1), HCRTR1(2), HCRTR2(1), HRH1(1), HRH2(2), HRH3(2), HTR1A(1), HTR1B(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(4), LHCGR(4), MAS1(2), MC3R(2), MC4R(1), NMUR1(1), NMUR2(2), NPY1R(3), NPY2R(1), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(5), OR1F1(1), OR1Q1(2), OR7A5(2), P2RY1(2), P2RY10(1), P2RY11(1), P2RY13(2), P2RY2(1), P2RY6(1), PPYR1(1), PTGDR(1), PTGFR(1), RHO(2), SSTR2(1), SSTR3(2)	88127754	150	122	150	54	40	16	38	36	20	0	0.42	1.00	1.00
494	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(1), BRAF(3), C7orf16(1), CACNA1A(6), CRHR1(3), GNAI1(1), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(5), GRIA1(6), GRIA2(1), GRIA3(6), GRID2(3), GRM1(3), GRM5(1), GUCY1A2(3), GUCY2C(5), GUCY2D(1), GUCY2F(2), IGF1(1), IGF1R(2), ITPR1(8), ITPR2(3), ITPR3(4), KRAS(4), LYN(4), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NOS1(3), NOS3(2), NPR1(2), NPR2(2), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PPP2CA(1), PPP2CB(2), PRKCG(2), PRKG1(1), PRKG2(6), RAF1(1), RYR1(11)	85565376	146	121	142	43	31	37	42	19	17	0	0.074	1.00	1.00
495	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), DRD2(1), EGF(2), EGFR(5), GJA1(2), GNAI1(1), GNAI2(1), GNAQ(1), GNAS(5), GRB2(1), GRM1(3), GRM5(1), GUCY1A2(3), GUCY2C(5), GUCY2D(1), GUCY2F(2), HTR2A(3), HTR2B(1), HTR2C(1), ITPR1(8), ITPR2(3), ITPR3(4), KRAS(4), MAP2K1(1), MAP2K2(1), MAP2K5(2), MAPK1(1), MAPK3(1), NPR1(2), NPR2(2), PDGFB(1), PDGFRA(3), PDGFRB(2), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PRKACA(1), PRKCG(2), PRKG1(1), PRKG2(6), PRKX(1), RAF1(1), SOS1(4), SOS2(2), TJP1(4), TUBA1B(2), TUBA1C(2), TUBA3C(2), TUBA3D(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1)	100963980	151	118	149	57	33	28	46	23	21	0	0.72	1.00	1.00
496	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(12), AKT3(3), CAPN1(3), CAPN10(1), CAPN11(1), CAPN2(2), CAPN3(1), CAPN6(2), CAV1(1), GRB2(1), ILK(2), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(2), ITGA4(1), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(2), ITGA9(2), ITGAD(1), ITGAE(1), ITGAL(1), ITGAM(1), ITGAV(5), ITGAX(4), ITGB1(2), ITGB2(3), ITGB3(2), ITGB4(4), ITGB5(2), ITGB6(1), ITGB8(2), MAP2K1(1), MAP2K2(1), MAP2K3(1), MAPK10(1), MAPK4(4), MAPK6(1), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PTK2(3), PXN(1), RAPGEF1(3), RHO(2), ROCK1(1), ROCK2(2), SDCCAG8(5), SHC1(1), SHC3(1), SORBS1(4), SOS1(4), TLN1(9), TNS1(4), VAV2(1), VAV3(1), VCL(3)	104524641	145	116	135	54	25	37	31	27	25	0	0.65	1.00	1.00
497	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), AKAP1(2), AKAP11(5), AKAP12(3), AKAP3(2), AKAP4(6), AKAP6(6), AKAP8(1), AKAP9(9), ARHGEF1(5), GNAI2(1), GNAO1(1), GNAQ(1), GNB1(1), GNB3(3), ITPR1(8), KCNJ3(1), KRAS(4), PALM2(1), PDE1A(2), PDE1B(2), PDE1C(1), PDE4A(1), PDE4B(2), PDE4C(4), PDE4D(6), PDE8A(1), PLCB3(1), PPP3CA(3), PRKACA(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(1), PRKD1(2), PRKD3(2), RHOA(2), USP5(4)	89828232	132	113	131	50	27	19	48	24	14	0	0.80	1.00	1.00
498	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(4), ADCY8(4), ADK(1), ADSL(2), AK2(1), AK5(2), AMPD1(6), ATIC(3), ATP1B1(1), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(2), DGUOK(1), ENPP1(4), ENPP3(2), ENTPD1(2), ENTPD2(2), FHIT(1), GMPS(1), GUCY1A2(3), GUCY2C(5), GUCY2D(1), GUCY2F(2), IMPDH1(2), IMPDH2(1), NPR1(2), NPR2(2), NT5E(3), PAICS(1), PAPSS1(2), PDE1A(2), PDE4A(1), PDE4B(2), PDE4C(4), PDE4D(6), PDE5A(1), PDE6B(2), PDE6C(4), PDE6G(1), PDE8A(1), PDE9A(3), PFAS(1), PKLR(1), POLB(1), POLD2(1), POLE(5), POLG(1), POLL(1), POLQ(6), POLR1B(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), PPAT(1), PRPS2(1), PRUNE(3), RRM1(1), RRM2(1)	97752642	143	113	142	54	25	21	51	23	23	0	0.87	1.00	1.00
499	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(3), AMY2A(1), ASCC3(2), ATP13A2(1), DDX23(1), DDX4(1), DDX41(2), DDX50(3), DDX51(1), DDX55(3), DDX56(1), DHX58(2), ENPP1(4), ENPP3(2), ENTPD7(3), EP400(2), ERCC3(2), G6PC2(2), GAA(2), GANC(1), GBE1(3), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(1), HK1(1), HK3(2), IFIH1(1), MGAM(9), MOV10L1(3), NUDT5(1), NUDT8(1), PGM1(2), PGM3(1), PYGB(3), PYGL(1), PYGM(4), RAD54B(4), RAD54L(2), SETX(8), SI(6), SKIV2L2(1), SMARCA2(4), SMARCA5(2), TREH(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B11(1), UGT2B15(3), UGT2B28(2), UGT2B4(2), UXS1(2)	96218460	128	111	128	32	22	19	37	30	20	0	0.12	1.00	1.00
500	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(3), ADCY3(2), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(4), ADCY8(4), ADCY9(5), CAMK2A(1), CAMK2D(3), CAMK2G(1), CREB1(1), CREB3(1), CREB3L1(2), CREB3L2(2), CREB3L3(3), CREBBP(2), DCT(2), DVL1(2), DVL3(1), EDN1(2), EDNRB(1), EP300(3), FZD1(1), FZD3(3), FZD6(2), FZD7(1), FZD8(1), FZD9(1), GNAI1(1), GNAI2(1), GNAO1(1), GNAQ(1), GNAS(5), KIT(5), KITLG(2), KRAS(4), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PRKACA(1), PRKCG(2), PRKX(1), RAF1(1), TCF7(3), TCF7L2(2), TYR(4), TYRP1(2), WNT10B(1), WNT11(2), WNT2(1), WNT2B(1), WNT3A(2), WNT5B(2), WNT6(1), WNT7A(6), WNT8B(1), WNT9A(1)	81496701	133	111	131	59	33	23	42	20	15	0	0.94	1.00	1.00
501	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(5), ABCA10(3), ABCA12(5), ABCA13(14), ABCA3(4), ABCA4(6), ABCA5(4), ABCA6(3), ABCA7(5), ABCA8(5), ABCA9(4), ABCB1(3), ABCB10(2), ABCB11(6), ABCB4(1), ABCB5(2), ABCB6(1), ABCB7(2), ABCB8(2), ABCB9(1), ABCC1(3), ABCC10(3), ABCC11(2), ABCC12(5), ABCC2(4), ABCC3(1), ABCC4(4), ABCC5(2), ABCC6(2), ABCC8(7), ABCC9(5), ABCD1(2), ABCD2(2), ABCD3(2), ABCG1(2), ABCG5(2), CFTR(6), TAP1(2)	90399621	134	110	134	39	24	18	54	22	16	0	0.22	1.00	1.00
502	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(3), BDKRB1(2), BDKRB2(1), C1QB(1), C2(1), C3(3), C3AR1(1), C4BPA(1), C4BPB(2), C5(3), C6(4), C7(5), C9(1), CD46(1), CD55(2), CFB(1), CFH(8), CPB2(1), CR1(8), CR2(2), F12(1), F13A1(3), F2(3), F2R(2), F5(11), F7(1), F8(1), F9(1), FGA(3), FGG(1), KLKB1(1), KNG1(3), MASP1(1), MASP2(1), MBL2(1), PLAT(2), PLAU(2), PLG(4), PROC(1), PROS1(1), SERPINA1(4), SERPINA5(3), SERPINC1(3), SERPIND1(1), SERPINE1(2), TFPI(1), VWF(8)	68212794	117	102	116	34	13	24	41	22	17	0	0.30	1.00	1.00
503	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(3), ADCY8(4), ARAF(1), ATF4(1), BRAF(3), CACNA1C(6), CAMK2A(1), CAMK2D(3), CAMK2G(1), CREBBP(2), EP300(3), GNAQ(1), GRIA1(6), GRIA2(1), GRIN1(1), GRIN2A(10), GRIN2B(8), GRIN2C(5), GRIN2D(4), GRM1(3), GRM5(1), ITPR1(8), ITPR2(3), ITPR3(4), KRAS(4), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), PLCB1(4), PLCB2(2), PLCB3(1), PLCB4(6), PPP1R12A(2), PPP1R1A(2), PPP3CA(3), PPP3CB(3), PRKACA(1), PRKCG(2), PRKX(1), RAF1(1), RAPGEF3(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(2), RPS6KA6(3)	78694512	129	102	126	48	29	26	38	18	18	0	0.59	1.00	1.00
504	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(4), CD14(1), CD19(2), CD1A(1), CD1B(3), CD1C(2), CD1D(3), CD1E(3), CD2(2), CD22(2), CD33(1), CD34(1), CD36(1), CD37(1), CD38(2), CD3E(1), CD3G(1), CD4(2), CD5(2), CD55(2), CD8A(1), CD9(2), CR1(8), CR2(2), CSF1(2), CSF2RA(2), CSF3R(2), DNTT(3), EPOR(2), FCGR1A(1), FLT3(3), FLT3LG(1), HLA-DRB1(4), HLA-DRB5(1), IL11RA(2), IL1A(1), IL1R1(1), IL1R2(4), IL3RA(1), IL4R(1), IL5RA(1), IL6(2), IL6R(1), IL7R(1), ITGA1(4), ITGA2(3), ITGA2B(2), ITGA4(1), ITGA5(1), ITGA6(3), ITGAM(1), ITGB3(2), KIT(5), KITLG(2), TFRC(1), TPO(6)	62238813	117	97	117	33	21	23	33	20	20	0	0.11	1.00	1.00
505	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	86	ACVR1(1), ACVR1B(5), ACVR1C(1), ACVR2A(3), AMHR2(2), BMP2(3), BMP4(2), BMP5(1), BMP6(2), BMP8B(1), BMPR1B(2), BMPR2(2), CHRD(3), COMP(3), CREBBP(2), CUL1(1), E2F4(2), E2F5(1), EP300(3), FST(1), GDF5(1), GDF6(2), ID2(1), INHBA(1), INHBC(1), INHBE(1), LEFTY1(1), LEFTY2(1), LTBP1(5), MAPK1(1), MAPK3(1), MYC(1), NODAL(1), PITX2(2), PPP2CA(1), PPP2CB(2), RBL1(1), RBL2(1), RHOA(2), ROCK1(1), ROCK2(2), RPS6KB2(4), SMAD2(3), SMAD3(2), SMAD4(1), SMAD9(2), SMURF2(1), SP1(2), TFDP1(1), TGFB3(1), TGFBR1(2), TGFBR2(3), THBS1(4), THBS2(1), THBS3(2), THBS4(1), ZFYVE16(3), ZFYVE9(3)	73937838	107	94	105	34	21	15	25	19	27	0	0.58	1.00	1.00
506	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	ALG1(1), ALG10(1), ALG10B(4), ALG11(1), ALG12(1), ALG13(3), ALG2(2), ALG6(1), ALG8(1), ALG9(1), B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), C1GALT1(1), C1GALT1C1(1), CHPF(1), CHST1(1), CHST11(1), CHST2(3), CHST3(1), DPAGT1(2), EXT1(4), EXT2(2), EXTL3(3), FUT11(1), GALNT10(2), GALNT11(4), GALNT13(3), GALNT3(2), GALNT4(1), GALNT5(3), GALNT7(2), GALNT9(1), GALNTL1(1), GALNTL5(3), GANAB(1), GCNT4(1), HS2ST1(2), HS3ST2(1), HS3ST5(3), HS6ST1(1), HS6ST2(3), HS6ST3(1), MAN1A1(1), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT3(1), MGAT4B(1), MGAT5(2), MGAT5B(4), NDST3(1), OGT(2), RPN1(2), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(3), UST(2), WBSCR17(4), XYLT1(1), XYLT2(1)	81492645	112	92	112	52	18	21	29	21	23	0	0.98	1.00	1.00
507	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	90	CD2BP2(1), CLK3(1), CLK4(1), COL2A1(4), CPSF1(3), CPSF3(1), CPSF4(3), CSTF2(1), CSTF2T(2), CSTF3(3), DDX20(2), DHX15(2), DHX38(2), DHX8(1), DICER1(2), FUS(1), GIPC1(1), LOC440563(2), NCBP1(1), NUDT21(1), NXF1(2), PABPN1(1), PAPOLA(1), POLR2A(2), PRPF3(2), PRPF4(2), PRPF4B(3), PRPF8(6), PSKH1(2), PTBP1(2), RBM17(1), RBM5(2), RNGTT(1), SF3B1(10), SF3B2(2), SF3B4(2), SF4(4), SFRS14(1), SFRS16(4), SFRS2(1), SFRS4(2), SFRS5(1), SFRS9(1), SNRPB(1), SNRPN(2), SNURF(1), SPOP(1), SRPK1(2), SRRM1(2), SUPT5H(5), TXNL4A(1), XRN2(3)	79639560	108	92	104	22	16	23	29	23	16	1	0.056	1.00	1.00
508	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	68	ACACB(8), ACSL3(1), ACSL4(2), ACSL5(1), ACSL6(2), AKT1(12), AKT2(1), AKT3(3), CAMKK1(3), CAMKK2(2), CD36(1), CPT1A(3), CPT1B(2), CPT1C(2), CPT2(3), G6PC2(2), IKBKB(3), IRS1(1), IRS4(4), JAK1(2), JAK2(5), JAK3(2), LEPR(3), MAPK10(1), MAPK8(2), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), NPY(1), PCK1(1), PCK2(1), PPARA(1), PPARGC1A(2), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1), PRKAG3(2), PRKCQ(3), PTPN11(1), RELA(1), SLC2A4(1), STAT3(1), TNFRSF1A(1), TYK2(4)	61637511	103	88	92	28	19	23	25	19	16	1	0.16	1.00	1.00
509	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(2), AGPAT3(2), AGPAT6(1), CDS1(2), CDS2(1), CHAT(1), CHKB(1), CHPT1(1), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), DGKI(6), ESCO1(3), ETNK1(3), ETNK2(1), GNPAT(2), GPAM(1), GPD1(2), GPD1L(1), GPD2(1), LCAT(1), MYST3(2), MYST4(6), PCYT1A(1), PCYT1B(3), PHOSPHO1(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(3), PLA2G4A(7), PLA2G6(2), PLD1(1), PNPLA3(2), PPAP2A(1), PPAP2C(2), PTDSS1(1), PTDSS2(1)	50287302	83	74	80	26	14	16	22	20	10	1	0.40	1.00	1.00
510	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ABP1(1), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(1), AOC3(2), AOX1(3), CARM1(1), DBH(4), DCT(2), DDC(1), ECH1(1), ESCO1(3), FAH(1), GOT2(1), GSTZ1(1), HGD(1), HPD(1), LCMT1(1), LCMT2(5), MAOA(2), MAOB(1), METTL2B(2), MYST3(2), MYST4(6), PNPLA3(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), TPO(6), TYR(4), TYRP1(2), WBSCR22(2)	44866458	83	72	83	25	16	15	29	9	13	1	0.42	1.00	1.00
511	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	CAD(7), CTPS2(2), DPYD(1), DPYS(1), ENTPD1(2), ENTPD4(2), ENTPD6(1), NME6(1), NME7(3), NT5C1B(4), NT5C3(1), NT5E(3), POLA1(4), POLD2(1), POLD4(1), POLE(5), POLE2(1), POLE3(1), POLR1A(2), POLR1B(2), POLR1C(2), POLR1D(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), POLR3A(1), POLR3B(3), POLR3GL(2), RRM1(1), RRM2(1), TK2(1), UCK2(2), UMPS(2), UPB1(3), UPP1(2), UPRT(1)	62948106	76	67	76	32	12	12	24	16	12	0	0.87	1.00	1.00
512	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	ATP8A1(2), AVPR1B(1), BDKRB1(2), BDKRB2(1), BRS3(2), C3AR1(1), CCKBR(1), CCR1(1), CCR10(1), CCR2(4), CCR3(1), CCR5(1), CCR7(2), CX3CR1(2), CXCR3(2), EDNRA(1), EDNRB(1), FPR1(1), FSHR(4), GALR1(2), GALR2(1), GALT(1), GHSR(1), GNB2L1(1), GPR77(2), GRPR(1), LHCGR(4), MC2R(1), MC3R(2), MC4R(1), NPY1R(3), NPY2R(1), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(3), OPRM1(5), PPYR1(1), SSTR2(1), SSTR3(2), TACR2(1), TSHR(4)	38606529	74	67	74	26	15	10	20	20	9	0	0.36	1.00	1.00
513	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(3), BMP4(2), BMP5(1), BMP6(2), BMP8B(1), BTRC(1), CSNK1A1L(3), CSNK1E(2), CSNK1G3(1), DHH(1), GLI1(2), GLI2(3), GLI3(4), LRP2(18), PRKACA(1), PRKX(1), PTCH1(6), SMO(2), SUFU(2), WNT10B(1), WNT11(2), WNT2(1), WNT2B(1), WNT3A(2), WNT5B(2), WNT6(1), WNT7A(6), WNT8B(1), WNT9A(1), ZIC2(1)	44272254	75	65	75	27	26	9	16	16	8	0	0.56	1.00	1.00
514	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACAA1(1), ACOX1(2), ACOX3(2), ACSL3(1), ACSL4(2), ACSL5(1), ACSL6(2), APOA5(1), AQP7(3), CD36(1), CPT1A(3), CPT1B(2), CPT1C(2), CPT2(3), CYP27A1(1), CYP8B1(1), EHHADH(2), FABP1(1), FABP2(1), FABP4(1), FABP6(1), FADS2(4), GK2(2), HMGCS2(1), ILK(2), LPL(1), PCK1(1), PCK2(1), PLTP(1), PPARA(1), PPARG(1), SCD(1), SLC27A2(1), SLC27A4(4), SLC27A5(2), SORBS1(4), UBC(7), UCP1(1)	48979749	69	64	69	28	10	14	18	13	14	0	0.83	1.00	1.00
515	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(2), ADCY6(1), ADCY8(4), CACNA1A(6), CACNA1B(8), GNAS(5), GNAT3(1), GNB1(1), GNB3(3), GRM4(1), ITPR3(4), KCNB1(2), PDE1A(2), PLCB2(2), PRKACA(1), PRKX(1), SCNN1B(1), TAS1R1(1), TAS1R2(2), TAS1R3(1), TAS2R1(1), TAS2R10(1), TAS2R13(1), TAS2R14(1), TAS2R16(3), TAS2R3(1), TAS2R40(1), TAS2R43(4), TAS2R46(1), TAS2R5(1), TAS2R8(1), TAS2R9(2), TRPM5(3)	44161728	70	64	70	34	17	13	13	16	11	0	0.93	1.00	1.00
516	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(12), BDKRB2(1), CAV1(1), CHRM1(2), CHRNA1(1), FLT1(2), FLT4(1), KDR(2), NOS3(2), PDE2A(3), PDE3A(7), PDE3B(1), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PRKG1(1), PRKG2(6), RYR2(24)	32463210	70	64	60	33	8	21	26	11	4	0	0.87	1.00	1.00
517	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(3), AMY2A(1), ENPP1(4), ENPP3(2), GAA(2), GANAB(1), GBE1(3), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(1), HK1(1), HK3(2), MGAM(9), PGM1(2), PGM3(1), PYGB(3), PYGL(1), PYGM(4), RNPC3(1), SI(6), UCHL3(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2B15(3), UGT2B4(2), UXS1(2)	44375175	70	64	70	21	12	9	20	17	12	0	0.45	1.00	1.00
518	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	59	APC(3), AXIN1(1), CCND1(1), CCND3(3), CSNK1E(2), DVL1(2), DVL3(1), FBXW2(2), FZD1(1), FZD3(3), FZD6(2), FZD7(1), FZD8(1), FZD9(1), JUN(1), LDLR(1), MAPK10(1), MYC(1), PAFAH1B1(2), PLAU(2), PPP2R5C(1), PPP2R5E(1), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(1), PRKD1(2), RHOA(2), SFRP4(1), TCF7(3), WNT10B(1), WNT11(2), WNT2(1), WNT2B(1), WNT5B(2), WNT6(1), WNT7A(6)	44264142	65	60	65	25	15	11	16	16	6	1	0.65	1.00	1.00
519	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), AKR1C1(2), AKR1C2(2), AKR1C3(1), AKR1C4(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), CYP1A2(1), CYP1B1(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2F1(1), CYP2S1(4), CYP3A4(3), CYP3A43(1), CYP3A7(4), DHDH(1), EPHX1(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTK1(1), GSTO2(1), GSTT1(1), GSTZ1(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B11(1), UGT2B15(3), UGT2B28(2), UGT2B4(2)	44794971	69	59	69	23	9	15	28	9	8	0	0.44	1.00	1.00
520	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(1), ACTG2(2), AKT1(12), FLNA(5), FLNC(9), FSCN3(1), GDI1(4), LIMK1(3), MYH2(2), MYLK(6), MYLK2(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), RHO(2), ROCK1(1), ROCK2(2), RPS4X(1), WASF1(3), WASL(1)	36197772	63	59	53	22	8	22	17	9	7	0	0.46	1.00	1.00
521	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	CREBBP(2), CTBP2(1), DLL1(1), DLL4(1), DTX1(4), DTX2(2), DTX4(1), DVL1(2), DVL3(1), EP300(3), HDAC1(2), HDAC2(3), JAG1(1), JAG2(1), MAML1(1), MAML2(3), MAML3(2), NCOR2(3), NCSTN(2), NOTCH1(2), NOTCH2(7), NOTCH3(3), NUMB(1), NUMBL(4), PSEN1(1), PSEN2(3), PTCRA(1), RBPJL(4), SNW1(2)	50645244	64	56	63	26	13	14	17	8	12	0	0.71	1.00	1.00
522	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(1), CTLA4(1), DAG1(1), EPHB2(2), FBXW7(2), GRAP2(1), GRB2(1), ITK(4), ITPKA(1), ITPKB(8), LAT(1), LCP2(1), MAPK1(1), NCK1(1), NFAT5(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIE(1), PAK1(2), PAK2(1), PAK3(2), PAK6(1), PAK7(1), PLCG1(5), PTPRC(1), RAF1(1), RASGRP2(2), RASGRP4(1), SOS1(4), SOS2(2), VAV1(2), ZAP70(1)	42438942	61	56	61	17	13	13	13	13	8	1	0.31	1.00	1.00
523	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ABP1(1), ACAT1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), AOX1(3), CARM1(1), CAT(1), CYP1A2(1), CYP1B1(1), DDC(1), ECHS1(1), EHHADH(2), GCDH(1), HADH(1), HSD17B10(1), HSD17B4(4), INMT(2), KMO(1), KYNU(1), LCMT1(1), LCMT2(5), LNX1(2), MAOA(2), MAOB(1), METTL2B(2), OGDH(2), OGDHL(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), TPH2(1), WARS2(1), WBSCR22(2)	46074132	64	55	64	26	8	18	24	6	8	0	0.76	1.00	1.00
524	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP4A(5), ATP4B(1), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(1), ATP6V0E1(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), COX10(3), COX15(1), COX4I2(1), COX5A(1), COX6C(1), COX7B2(1), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA2(1), NDUFA3(1), NDUFA9(1), NDUFB3(1), NDUFB4(1), NDUFB9(1), NDUFS2(2), NDUFS3(1), NDUFS7(1), NDUFV1(1), NDUFV2(1), PPA1(2), SDHA(1), SDHB(1), TCIRG1(1), UQCRC1(2), UQCRC2(1)	43449393	58	53	58	16	9	7	21	11	10	0	0.38	1.00	1.00
525	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(1), ARSE(2), CARM1(1), CYP11B1(2), CYP11B2(3), HSD11B1(2), HSD17B1(1), HSD17B2(1), HSD3B2(3), LCMT1(1), LCMT2(5), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), SRD5A1(1), SRD5A2(3), SULT1E1(2), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B11(1), UGT2B15(3), UGT2B28(2), UGT2B4(2), WBSCR22(2)	37863267	59	52	59	21	11	11	24	7	6	0	0.62	1.00	1.00
526	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(3), AR(4), ESR1(2), ESR2(2), HNF4A(3), NR1D1(2), NR1D2(1), NR1H2(3), NR1I3(1), NR2C2(1), NR2E1(2), NR4A1(1), NR4A2(1), NR5A2(4), PGR(2), PPARA(1), PPARG(1), RARA(1), RARB(4), RARG(3), ROR1(7), RORC(3), THRA(1), THRB(1)	30889989	54	52	54	20	10	13	10	7	14	0	0.62	1.00	1.00
527	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(12), APC(3), ASAH1(1), DAG1(1), EPHB2(2), GNAI1(1), GNAQ(1), ITPR1(8), ITPR2(3), ITPR3(4), KCNJ3(1), MAPK1(1), PITX2(2), PTX3(1), RHO(2), RYR1(11)	35328267	54	52	44	20	7	25	7	8	7	0	0.28	1.00	1.00
528	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(1), AGXT(1), AGXT2(1), ALAS2(3), AMT(2), AOC2(1), AOC3(2), BHMT(1), CBS(2), CHKB(1), CTH(3), DAO(1), DLD(1), DMGDH(4), GARS(1), GATM(4), GCAT(2), MAOA(2), MAOB(1), PIPOX(2), RDH11(2), RDH12(1), RDH14(1), SARDH(2), SARS(2), SARS2(2), TARS(4), TARS2(5)	33053865	55	51	55	21	8	12	12	13	10	0	0.68	1.00	1.00
529	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(1), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), AOX1(3), CAT(1), CYP1A2(1), CYP2A13(4), CYP2A6(1), CYP2A7(1), CYP2B6(2), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2D6(2), CYP2F1(1), CYP3A4(3), CYP3A7(4), CYP4B1(3), CYP4F8(3), DDC(1), ECHS1(1), EHHADH(2), GCDH(1), KMO(1), KYNU(1), MAOA(2), MAOB(1), WARS2(1)	41909634	61	51	61	25	7	14	20	12	8	0	0.79	1.00	1.00
530	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), CAMK2A(1), CAMK2D(3), CAMK2G(1), CDK5(1), F2(3), GNAI1(1), GNB1(1), GRB2(1), JAK2(5), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPT(1), MYLK(6), PLCG1(5), PTK2B(3), RAF1(1), SHC1(1), SOS1(4), STAT1(1), STAT3(1), STAT5A(3)	32132139	53	50	53	22	8	10	15	9	11	0	0.81	1.00	1.00
531	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN2(8), ACTN3(1), BCR(1), CAPN1(3), CAV1(1), CRKL(1), GRB2(1), ITGA1(4), ITGB1(2), JUN(1), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(2), PTK2(3), PXN(1), RAF1(1), ROCK1(1), SHC1(1), SOS1(4), TLN1(9), VCL(3)	36335169	53	50	53	17	11	9	13	9	11	0	0.52	1.00	1.00
532	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3L1(1), CAD(7), CTPS2(2), DPYD(1), DPYS(1), ENTPD1(2), NT5E(3), POLB(1), POLD2(1), POLE(5), POLG(1), POLL(1), POLQ(6), POLR1B(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), RRM1(1), RRM2(1), TK2(1), UCK2(2), UMPS(2), UPB1(3), UPP1(2)	43647123	54	50	54	23	5	10	17	10	12	0	0.84	1.00	1.00
533	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), AGPAT3(2), AKR1B1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CEL(1), DGAT1(1), DGKA(3), DGKB(1), DGKD(1), DGKE(2), DGKG(6), DGKH(1), GLA(2), GLB1(1), LCT(6), LIPC(1), LIPG(1), LPL(1), PNLIP(2), PNLIPRP1(4), PNLIPRP2(1), PPAP2A(1), PPAP2C(2)	37096176	55	49	54	19	12	10	17	8	8	0	0.59	1.00	1.00
534	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(1), AGXT(1), AGXT2(1), ALAS2(3), AMT(2), AOC2(1), AOC3(2), BHMT(1), CBS(2), CHKB(1), CPT1B(2), CTH(3), DAO(1), DLD(1), DMGDH(4), GARS(1), GATM(4), GCAT(2), MAOA(2), MAOB(1), PLCB2(2), PLCG1(5), PLCG2(2), SARDH(2), SARS(2), TARS(4)	32456619	53	48	53	20	8	10	13	11	11	0	0.71	1.00	1.00
535	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACAA2(1), ACADSB(3), ACADVL(2), ACAT1(1), ACOX1(2), ACOX3(2), ACSL3(1), ACSL4(2), ACSL5(1), ACSL6(2), ADH1A(1), ADH6(1), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CPT1A(3), CPT1B(2), CPT1C(2), CPT2(3), ECHS1(1), EHHADH(2), GCDH(1), HADH(1), HADHB(1), HSD17B10(1), HSD17B4(4), PECI(1)	37314693	50	48	50	18	7	14	17	8	4	0	0.56	1.00	1.00
536	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	AKT1(12), AKT2(1), AKT3(3), ANKRD6(4), APC(3), AXIN1(1), CER1(1), DKK2(1), DKK3(1), DKK4(1), DVL1(2), GSK3A(1), LRP1(9), MVP(1), NKD1(1), NKD2(2), PSEN1(1), PTPRA(1), SFRP1(3), WIF1(2)	31142475	51	48	41	17	11	18	8	7	7	0	0.30	1.00	1.00
537	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	46	AASDHPPT(2), AASS(3), ACAT1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DOT1L(4), ECHS1(1), EHHADH(2), EHMT1(3), GCDH(1), HADH(1), HSD17B10(1), HSD17B4(4), OGDH(2), OGDHL(2), PIPOX(2), PLOD1(1), PLOD2(1), PLOD3(2), RDH11(2), RDH12(1), RDH14(1), SETD7(1), SETDB1(7)	42221439	50	47	49	22	6	13	18	8	5	0	0.83	1.00	1.00
538	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F12(1), F2(3), F5(11), F7(1), F8(1), F9(1), FGA(3), FGG(1), LPA(7), PLAT(2), PLAU(2), PLG(4), SERPINE1(2), VWF(8)	26821821	47	45	46	17	6	7	19	9	6	0	0.64	1.00	1.00
539	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), AADAC(3), ABAT(3), ACAT1(1), ACSM1(1), ALDH1A3(3), ALDH1B1(1), ALDH5A1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), HADH(1), HMGCS1(1), HMGCS2(1), HSD17B10(1), HSD17B4(4), ILVBL(2), L2HGDH(1), OXCT1(1), OXCT2(1), PDHA1(2), PDHA2(2), PDHB(1), PLA1A(2), RDH11(2), RDH12(1), RDH14(1)	31082649	47	45	47	18	3	14	12	14	4	0	0.72	1.00	1.00
540	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2D(3), CAMK2G(1), DAG1(1), ITPKA(1), ITPKB(8), ITPR1(8), ITPR2(3), ITPR3(4), NFAT5(3), PDE6A(1), PDE6B(2), PDE6C(4), PDE6G(1), SLC6A13(2), TF(1)	27843933	44	44	44	16	4	12	8	11	9	0	0.58	1.00	1.00
541	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(3), CAPN2(2), CXCR3(2), EGF(2), EGFR(5), ITGA1(4), ITGB1(2), MAPK1(1), MAPK3(1), MYLK(6), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTK2(3), PXN(1), TLN1(9)	25719096	45	43	45	17	6	11	14	11	3	0	0.69	1.00	1.00
542	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(1), AGMAT(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(2), ARG1(2), ARG2(1), ASL(3), CKMT2(2), CPS1(5), DAO(1), GATM(4), GOT2(1), MAOA(2), MAOB(1), NOS1(3), NOS3(2), OTC(1), P4HA2(1), P4HA3(1), P4HB(1), RARS(2)	33901569	47	42	47	15	7	10	19	8	3	0	0.45	1.00	1.00
543	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(3), ACAA1(1), ACAA2(1), ACAT1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOX1(3), BCAT1(3), BCAT2(2), BCKDHA(1), DLD(1), ECHS1(1), EHHADH(2), HADH(1), HADHB(1), HIBCH(2), HMGCS1(1), HMGCS2(1), HSD17B10(1), HSD17B4(4), IVD(1), MCCC1(2), MUT(1), OXCT1(1), OXCT2(1), PCCA(1), PCCB(1)	32908863	43	42	43	15	4	10	14	11	4	0	0.66	1.00	1.00
544	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(3), CREB1(1), ELK1(2), GNAI1(1), GNAQ(1), GNAS(5), GNB1(1), JUN(1), MAP2K1(1), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), PLCG1(5), PPP3CA(3), PPP3CB(3), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), RAF1(1), RPS6KA3(2)	25572573	43	41	43	14	8	9	12	9	5	0	0.53	1.00	1.00
545	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), ABO(4), B3GALNT1(1), B3GALT1(1), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), B4GALT6(1), FUT2(2), FUT3(4), FUT5(1), GBGT1(1), PIGA(1), PIGB(1), PIGG(1), PIGQ(3), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST3GAL5(2), ST3GAL6(1), ST6GALNAC4(1), ST8SIA1(1)	37372491	42	40	41	18	6	12	9	9	6	0	0.68	1.00	1.00
546	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	EEF1B2(1), EEF1D(1), EEF2(2), EEF2K(3), EIF1AX(2), EIF2AK1(1), EIF2AK3(1), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S1(1), EIF2S2(1), EIF2S3(1), EIF4A2(5), EIF4G1(1), EIF4G3(2), EIF5(2), EIF5B(2), ETF1(2), GSPT2(2), KIAA0664(1), PABPC1(3), PABPC3(3), SLC35A4(2)	34177377	43	40	43	14	8	7	13	5	10	0	0.59	1.00	1.00
547	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC7(1), CDK2(1), DIAPH2(1), MCM10(2), MCM2(1), MCM3(1), MCM4(2), MCM6(2), MCM7(2), NACA(3), ORC1L(1), ORC2L(1), ORC3L(1), POLD2(1), POLD4(1), POLE(5), POLE2(1), RFC1(2), RFC4(3), RPA1(1), UBC(7)	38659257	40	39	40	15	5	7	13	8	7	0	0.85	1.00	1.00
548	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP5(3), ARHGAP6(1), ARHGEF1(5), ARHGEF11(2), ARPC1A(1), ARPC1B(1), ARPC2(2), BAIAP2(2), GSN(1), LIMK1(3), MYLK(6), OPHN1(2), PIP5K1A(1), ROCK1(1), TLN1(9), VCL(3)	35765301	43	38	43	22	7	6	13	6	11	0	0.97	1.00	1.00
549	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(1), ALG10B(4), ALG11(1), ALG12(1), ALG13(3), ALG2(2), ALG5(1), ALG6(1), ALG8(1), ALG9(1), B4GALT1(2), B4GALT3(1), DPAGT1(2), GANAB(1), MAN1A1(1), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT3(1), MGAT4B(1), MGAT5(2), MGAT5B(4), RPN1(2)	31817292	39	36	39	15	3	10	12	7	7	0	0.76	1.00	1.00
550	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(3), ATF2(2), AXIN1(1), BMP10(1), BMP2(3), BMP4(2), BMP5(1), BMPR2(2), CHRD(3), DVL1(2), FZD1(1), MAP3K7(1), MEF2C(2), NPPA(1), RFC1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2)	27194973	36	34	35	19	6	7	8	9	6	0	0.95	1.00	1.00
551	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(1), AZIN1(1), CBX3(2), CLDN5(1), CRY1(1), EIF4G2(1), ETV6(2), HSPA8(3), IDI1(2), MYF6(1), NCKAP1(3), NR1D2(1), PER1(3), PER2(3), PPP2CB(2), TOB1(1), TUBB3(1), UCP3(1), VAPA(1), ZFR(5)	27775488	36	34	36	12	3	8	11	8	6	0	0.63	1.00	1.00
552	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(2), ANAPC4(1), ANAPC5(5), ANAPC7(2), BTRC(1), CDC23(1), CDC27(1), CUL1(1), CUL3(1), FBXW7(2), ITCH(1), SMURF2(1), UBA1(4), UBE2D2(2), UBE2E1(1), UBE2E3(1), WWP1(1), WWP2(6)	31442619	34	34	34	13	8	11	4	6	5	0	0.72	1.00	1.00
553	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(3), ABP1(1), ACADSB(3), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), CNDP1(2), DPYD(1), DPYS(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), MLYCD(2), UPB1(3)	21822801	35	33	35	15	3	10	10	8	4	0	0.78	1.00	1.00
554	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(3), ACACA(3), ACACB(8), ACAT1(1), ACSS1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), HIBCH(2), LDHC(1), MLYCD(2), MUT(1), PCCA(1), PCCB(1), SUCLA2(1)	30260802	33	32	33	12	3	7	12	9	2	0	0.69	1.00	1.00
555	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(4), POLB(1), POLD2(1), POLD4(1), POLE(5), POLE2(1), POLE3(1), POLG(1), POLH(2), POLI(3), POLL(1), POLQ(6), REV1(2), REV3L(5)	31857345	34	32	34	12	2	5	12	8	7	0	0.80	1.00	1.00
556	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(8), BAIAP2(2), CASP1(1), CASP8(3), INSR(2), ITCH(1), MAGI1(3), MAGI2(7), RERE(2), WWP1(1), WWP2(6)	17922450	36	32	34	13	8	11	2	7	8	0	0.72	1.00	1.00
557	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP4B(1), ATP6V0A4(2), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(1), ATP6V1G2(1), ATP6V1H(1), ATP7A(6), ATP7B(1), COX10(3), COX5A(1), COX6C(1), NDUFA1(1), NDUFA10(1), NDUFB4(1), NDUFS2(2), NDUFV1(1), NDUFV2(1), SDHA(1), SDHB(1), UQCRC1(2)	29686878	35	32	35	13	8	6	8	6	7	0	0.70	1.00	1.00
558	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(1), CBS(2), CTH(3), GGT1(2), LCMT1(1), LCMT2(5), MAT1A(1), MAT2B(1), METTL2B(2), PAPSS1(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(1), SEPHS1(1), SEPHS2(1), WBSCR22(2)	18848232	36	31	36	13	10	9	9	0	8	0	0.42	1.00	1.00
559	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS2(3), COX10(3), COX15(1), CP(2), EARS2(3), EPRS(2), GUSB(1), HMBS(1), PPOX(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B11(1), UGT2B15(3), UGT2B28(2), UGT2B4(2)	32345586	33	31	33	15	6	3	14	6	4	0	0.93	1.00	1.00
560	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), ADRBK2(1), ARRB2(1), CAMK2A(1), CAMK2D(3), CAMK2G(1), CLCA1(1), CLCA2(1), CNGA3(3), CNGA4(2), CNGB1(2), GUCA1A(2), GUCA1C(1), PDE1C(1), PRKACA(1), PRKG1(1), PRKG2(6), PRKX(1)	23608962	31	31	31	19	6	8	7	7	3	0	0.96	1.00	1.00
561	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACAA2(1), ACADSB(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOX1(3), BCAT1(3), BCKDHA(1), ECHS1(1), EHHADH(2), HADHB(1), IVD(1), MCCC1(2), MUT(1), OXCT1(1), PCCA(1), PCCB(1)	27494610	32	31	32	14	2	7	12	8	3	0	0.86	1.00	1.00
562	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	C1GALT1(1), C1GALT1C1(1), GALNT10(2), GALNT11(4), GALNT13(3), GALNT3(2), GALNT4(1), GALNT5(3), GALNT7(2), GALNT9(1), GALNTL1(1), GALNTL5(3), GCNT4(1), OGT(2), ST3GAL1(1), ST6GALNAC1(3), WBSCR17(4)	24775569	35	30	35	14	6	4	10	4	11	0	0.79	1.00	1.00
563	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH5A1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), L2HGDH(1), OXCT1(1), PDHA1(2), PDHA2(2), PDHB(1), SDHB(1)	19613295	30	29	30	13	2	9	10	9	0	0	0.78	1.00	1.00
564	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(3), ABP1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(2), CNDP1(2), DPYD(1), DPYS(1), ECHS1(1), EHHADH(2), GAD1(2), GAD2(3), HIBCH(2), MLYCD(2), UPB1(3)	20191275	31	29	31	13	3	7	9	8	4	0	0.78	1.00	1.00
565	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CYP2C19(1), CYP2C9(2), DHRS2(3), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(3), MYST3(2), MYST4(6), PNPLA3(2)	23359011	30	29	30	13	3	7	10	7	2	1	0.83	1.00	1.00
566	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	30	AASDH(1), AASDHPPT(2), AASS(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DOT1L(4), ECHS1(1), EHHADH(2), EHMT1(3), GCDH(1), PLOD1(1), PLOD2(1), PLOD3(2)	26160186	30	29	30	17	3	7	11	5	4	0	0.96	1.00	1.00
567	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(2), ADRA1B(1), CHRM1(2), CHRM2(2), CHRM3(1), CHRM5(2), DRD2(1), DRD3(1), DRD4(1), HRH1(1), HRH2(2), HTR1A(1), HTR1B(1), HTR1E(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR5A(4)	19319742	30	29	30	13	12	0	9	3	6	0	0.75	1.00	1.00
568	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CDK7(2), ERCC3(2), GTF2E2(1), GTF2F2(1), GTF2H1(1), ILK(2), MNAT1(1), POLR1A(2), POLR1B(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), POLR3B(3), POLR3E(2), TAF6(1), TAF7(1), TBP(1)	26354874	30	28	30	14	6	7	7	4	6	0	0.74	1.00	1.00
569	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(3), ACACA(3), ACADSB(3), ACAT1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), ECHS1(1), EHHADH(2), LDHC(1), MLYCD(2), MUT(1), PCCA(1), PCCB(1), SUCLA2(1)	25275471	28	27	28	14	1	10	8	7	2	0	0.91	1.00	1.00
570	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(3), ABP1(1), AOC2(1), AOC3(2), CES1(2), CES7(1), ESCO1(3), LIPA(1), MYST3(2), MYST4(6), PLA1A(2), PNPLA3(2)	19039371	26	25	26	11	4	8	5	4	4	1	0.77	1.00	1.00
571	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGF(2), EGFR(5), GRB2(1), MAP2K1(1), MAPK1(1), MAPK3(1), PTPRB(5), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SPRY3(1)	19124547	26	25	26	13	4	5	6	6	5	0	0.95	1.00	1.00
572	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(3), EPHB2(2), F2(3), F2RL2(1), JUN(1), MAP2K5(2), MAPK1(1), MAPK8(2), MYEF2(2), PLD1(1), PLD3(2), PTK2(3), RAF1(1), RASAL1(2), TEC(1), VAV1(2)	21122127	29	25	29	10	5	7	9	3	5	0	0.55	1.00	1.00
573	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(3), CD3E(1), CD3G(1), CD4(2), CREBBP(2), GNAS(5), GNB1(1), HLA-DRB1(4), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTPRC(1), ZAP70(1)	16692468	24	24	24	10	4	5	5	7	3	0	0.74	1.00	1.00
574	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(1), AGT(3), EDN1(2), EDNRA(1), EDNRB(1), EGF(2), EGFR(5), JUN(1), MYC(1), NFKB1(1), PLCG1(5), RELA(1)	15534987	24	24	24	10	3	4	6	7	4	0	0.82	1.00	1.00
575	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(3), CD3E(1), CD3G(1), CD4(2), CREBBP(2), GNAS(5), GNB1(1), HLA-DRB1(4), PRKAR1A(1), PRKAR2A(1), PRKAR2B(1), PTPRC(1), ZAP70(1)	16692468	24	24	24	10	4	5	5	7	3	0	0.74	1.00	1.00
576	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B1(3), ALDH3B2(2), ALDH9A1(1), AOC2(1), AOC3(2), ASPA(2), CNDP1(2), DDC(1), HAL(2), MAOA(2), MAOB(1), PRPS2(1)	18594732	28	24	28	10	2	6	13	3	4	0	0.59	1.00	1.00
577	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(1), ACOT11(2), ACYP1(1), DHRS2(3), DHRS7(1), ECHS1(1), EHHADH(2), ESCO1(3), GCDH(1), ITGB1BP3(1), MYST3(2), MYST4(6), PNPLA3(2)	19635603	26	24	26	12	5	5	6	7	2	1	0.83	1.00	1.00
578	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(5), CETP(1), DGAT1(1), HMGCR(1), LCAT(1), LDLR(1), LIPC(1), LPL(1), LRP1(9), SCARB1(2), SOAT1(1)	20771790	24	24	24	11	5	6	8	1	4	0	0.83	1.00	1.00
579	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(5), COL4A2(4), COL4A3(2), COL4A4(2), COL4A5(4), COL4A6(4), P4HB(1), SLC23A1(2), SLC2A3(2)	20107620	26	24	26	12	6	5	7	6	2	0	0.75	1.00	1.00
580	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGT(3), COL4A1(5), COL4A2(4), COL4A3(2), COL4A4(2), COL4A5(4), COL4A6(4)	20047794	25	23	25	12	5	5	6	6	3	0	0.81	1.00	1.00
581	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1L(1), GOSR1(1), SNAP23(2), SNAP25(1), STX10(1), STX11(1), STX12(1), STX16(1), STX17(1), STX19(2), STX3(1), STX6(1), STX7(1), TSNARE1(4), USE1(1), VAMP1(1), VAMP3(1), VAMP7(1)	12881856	23	23	23	11	4	3	7	2	7	0	0.90	1.00	1.00
582	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(3), BCAT2(2), IARS(6), IARS2(2), ILVBL(2), LARS(1), LARS2(2), PDHA1(2), PDHA2(2), PDHB(1)	11908923	23	21	23	10	6	5	6	4	2	0	0.79	1.00	1.00
583	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(2), POLR1B(2), POLR1C(2), POLR1D(2), POLR2A(2), POLR2B(3), POLR2F(2), POLR2H(1), POLR3A(1), POLR3B(3), POLR3GL(2)	17691258	22	21	22	12	4	4	6	4	4	0	0.89	1.00	1.00
584	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CAPN2(2), EP300(3), HDAC1(2), HDAC2(3), NFATC1(1), NFATC2(1), PPP3CA(3), PPP3CB(3)	17986332	23	21	22	13	1	8	4	4	6	0	0.92	1.00	1.00
585	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(3), AXIN1(1), CREBBP(2), DVL1(2), EP300(3), FZD1(1), HDAC1(2), LDB1(1), PITX2(2), TRRAP(5)	24986988	22	21	21	11	2	3	5	7	5	0	0.92	1.00	1.00
586	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN2(8), ACTN3(1), CTNNA1(2), CTNNA2(4), PTK2(3), PXN(1), VCL(3)	14958528	22	20	22	12	6	4	6	2	4	0	0.92	1.00	1.00
587	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(2), AMT(2), ATIC(3), FTCD(1), MTHFD1(4), MTHFD1L(3), MTHFS(1), MTR(5)	14530620	21	20	21	10	1	6	6	3	5	0	0.88	1.00	1.00
588	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK1G(1), CAMK2A(1), CAMK2D(3), CAMK2G(1), HDAC5(2), MEF2A(1), MEF2C(2), PPARA(1), PPP3CA(3), PPP3CB(3), SLC2A4(1)	16291938	21	20	21	11	1	6	4	6	4	0	0.90	1.00	1.00
589	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(2), AMT(2), ATIC(3), MTHFD1(4), MTHFD1L(3), MTHFS(1), MTR(5)	13721448	20	19	20	10	1	6	6	2	5	0	0.90	1.00	1.00
590	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(3), AXIN1(1), BTRC(1), CCND1(1), CREBBP(2), CSNK2A1(1), DVL1(2), FZD1(1), HDAC1(2), MAP3K7(1), MYC(1), NLK(1), PPP2CA(1), WIF1(2)	22554402	20	19	20	12	2	6	5	4	3	0	0.96	1.00	1.00
591	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(1), UGT1A10(1), UGT1A3(1), UGT1A4(1), UGT1A6(2), UGT2A1(1), UGT2B10(2), UGT2B11(1), UGT2B15(3), UGT2B28(2), UGT2B4(2)	20869134	19	18	19	10	3	1	8	5	2	0	0.91	1.00	1.00
592	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(3), ACE2(1), AGT(3), ANPEP(4), CTSA(1), CTSG(1), ENPEP(2), MAS1(2), THOP1(1)	16157076	18	18	18	11	2	3	5	4	4	0	0.97	1.00	1.00
593	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(1), B3GAT2(1), B3GAT3(1), CHPF(1), CHST11(1), CHST3(1), DSE(7), UST(2), XYLT1(1), XYLT2(1)	9360741	17	17	17	10	6	5	4	1	1	0	0.87	1.00	1.00
594	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), DHCR24(1), EBP(1), FDFT1(1), FDPS(1), HMGCR(1), IDI1(2), LSS(2), NQO1(1), NSDHL(1), PMVK(1), SC4MOL(1), SQLE(1), VKORC1(1)	14746095	16	16	16	11	4	2	6	2	2	0	0.98	1.00	1.00
595	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADVL(2), ACSL3(1), ACSL4(2), CPT1A(3), CPT2(3), EHHADH(2), SLC25A20(1)	12761697	14	14	14	8	2	6	5	1	0	0	0.88	1.00	1.00
596	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(3), ABCB11(6), ABCB4(1), ABCC1(3), ABCC3(1)	11177322	14	14	14	12	2	2	6	2	2	0	0.99	1.00	1.00
597	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(3), AXIN1(1), BTRC(1), DLL1(1), DVL1(2), FZD1(1), NOTCH1(2), PSEN1(1)	16001934	12	12	12	10	1	3	2	5	1	0	0.99	1.00	1.00
598	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(2), GABRA3(3), GABRA5(1), GABRA6(3), PRKCE(1), SOD1(1)	6005415	11	11	11	5	2	2	4	3	0	0	0.75	1.00	1.00
599	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), ECHS1(1), EHHADH(2)	9291789	11	11	11	9	0	3	6	2	0	0	0.98	1.00	1.00
600	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1)	6035328	8	8	8	5	0	3	5	0	0	0	0.91	1.00	1.00
601	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1)	6035328	8	8	8	5	0	3	5	0	0	0	0.91	1.00	1.00
602	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(1), GPR109B(1), GPR161(2), GPR34(1), GPR75(1)	7546695	8	8	8	9	0	1	2	5	0	0	1.00	1.00	1.00
603	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), ACYP1(1), ECHS1(1), EHHADH(2), GCDH(1), SDHB(1)	6033300	7	7	7	6	1	1	2	3	0	0	0.96	1.00	1.00
604	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(1), ATF3(1), CYR61(1), IFRD1(1), IL1A(1), IL1R1(1), NR4A3(1)	8218470	7	7	7	5	2	1	3	1	0	0	0.92	1.00	1.00
605	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(1), NR0B2(2), NR1H4(1)	4032171	5	5	5	4	1	0	3	1	0	0	0.96	1.00	1.00
606	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), HMGCS1(1), HMGCS2(1), OXCT1(1), OXCT2(1)	5437575	5	5	5	4	0	1	2	2	0	0	0.96	1.00	1.00
607	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(1), CNR2(1), DNMT1(1), PTGDR(1), PTGFR(1)	8131266	5	5	5	6	1	0	1	3	0	0	1.00	1.00	1.00
608	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(1), SNAP25(1)	2471625	4	4	4	3	0	0	4	0	0	0	0.92	1.00	1.00
609	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(1), XYLT1(1), XYLT2(1)	4663386	4	4	4	5	3	0	0	1	0	0	0.98	1.00	1.00
610	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(1), XYLT1(1), XYLT2(1)	4663386	4	4	4	5	3	0	0	1	0	0	0.98	1.00	1.00
611	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(3), MMP9(1)	5851794	4	4	3	5	1	3	0	0	0	0	0.95	1.00	1.00
612	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(1), EHHADH(2)	3768531	3	3	3	4	0	0	1	2	0	0	0.98	1.00	1.00
613	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(2)	1529619	3	3	3	2	0	1	2	0	0	0	0.93	1.00	1.00
614	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACAT1(1), ECHS1(1)	4084392	2	2	2	4	0	1	0	1	0	0	0.99	1.00	1.00
615	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), OXCT1(1)	2570490	2	2	2	2	0	1	1	0	0	0	0.96	1.00	1.00
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		384306	0	0	0	0	0	0	0	0	0	0	1.00	1.00	1.00