E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.07 0.164 -9999.0 0.0 -0.408 66.0 66.0 KLHL20 -0.025 0.09 0.251 1.0 -0.247 17.0 18.0 CYFIP2 -0.006 0.13 -9999.0 0.0 -0.42 45.0 45.0 Rac1/GDP -0.035 0.117 0.269 4.0 -0.264 60.0 64.0 ENAH -0.065 0.162 -9999.0 0.0 -0.411 63.0 63.0 AP1M1 0.035 0.021 -9999.0 0.0 -0.42 1.0 1.0 RAP1B 0.033 0.03 -9999.0 0.0 -0.42 2.0 2.0 RAP1A 0.031 0.045 -9999.0 0.0 -0.42 5.0 5.0 CTNNB1 0.025 0.067 -9999.0 0.0 -0.42 11.0 11.0 CDC42/GTP -0.013 0.083 -9999.0 0.0 -0.227 13.0 13.0 ABI1/Sra1/Nap1 -0.046 0.054 -9999.0 0.0 -0.16 37.0 37.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.03 0.104 -9999.0 0.0 -0.233 58.0 58.0 RAPGEF1 -0.073 0.154 -9999.0 0.0 -0.364 79.0 79.0 CTNND1 0.034 0.022 -9999.0 0.0 -0.42 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.074 0.183 -9999.0 0.0 -0.351 144.0 144.0 CRK -0.069 0.162 -9999.0 0.0 -0.386 81.0 81.0 E-cadherin/gamma catenin/alpha catenin 0.018 0.098 -9999.0 0.0 -0.26 49.0 49.0 alphaE/beta7 Integrin 0.044 0.039 -9999.0 0.0 -0.3 5.0 5.0 IQGAP1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.035 0.021 -9999.0 0.0 -0.42 1.0 1.0 Rap1/GTP/I-afadin 0.047 0.064 -9999.0 0.0 -0.229 22.0 22.0 DLG1 -0.082 0.177 -9999.0 0.0 -0.399 88.0 88.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.031 0.056 -9999.0 0.0 -0.152 63.0 63.0 MLLT4 0.02 0.078 -9999.0 0.0 -0.42 15.0 15.0 ARF6/GTP/NME1/Tiam1 0.056 0.045 -9999.0 0.0 -0.235 9.0 9.0 PI3K -0.036 0.074 -9999.0 0.0 -0.193 62.0 62.0 ARF6 0.033 0.029 -9999.0 0.0 -0.42 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.004 0.104 -9999.0 0.0 -0.305 48.0 48.0 TIAM1 0.028 0.057 -9999.0 0.0 -0.42 8.0 8.0 E-cadherin(dimer)/Ca2+ 0.03 0.097 -9999.0 0.0 -0.219 57.0 57.0 AKT1 -0.024 0.053 0.173 3.0 -0.169 5.0 8.0 PIK3R1 0.019 0.08 -9999.0 0.0 -0.42 16.0 16.0 CDH1 -0.012 0.129 -9999.0 0.0 -0.42 45.0 45.0 RhoA/GDP -0.036 0.121 0.268 4.0 -0.27 63.0 67.0 actin cytoskeleton organization -0.017 0.068 0.175 2.0 -0.178 17.0 19.0 CDC42/GDP -0.033 0.116 0.268 4.0 -0.263 60.0 64.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.01 0.077 -9999.0 0.0 -0.216 56.0 56.0 ITGB7 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.033 0.104 -9999.0 0.0 -0.233 57.0 57.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.018 0.087 -9999.0 0.0 -0.215 56.0 56.0 mol:GDP -0.054 0.122 0.268 4.0 -0.298 64.0 68.0 CDC42/GTP/IQGAP1 0.045 0.014 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.028 0.042 -9999.0 0.0 -0.42 4.0 4.0 p120 catenin/RhoA/GDP -0.031 0.127 0.281 3.0 -0.278 62.0 65.0 RAC1/GTP/IQGAP1 0.046 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.049 0.033 -9999.0 0.0 -0.3 4.0 4.0 RHOA 0.026 0.061 -9999.0 0.0 -0.42 9.0 9.0 CDC42 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.035 0.021 -9999.0 0.0 -0.42 1.0 1.0 positive regulation of S phase of mitotic cell cycle -0.03 0.077 0.146 1.0 -0.185 80.0 81.0 NME1 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.08 0.175 -9999.0 0.0 -0.405 83.0 83.0 regulation of cell-cell adhesion -0.018 0.069 -9999.0 0.0 -0.174 57.0 57.0 WASF2 -0.016 0.042 0.115 2.0 -0.113 8.0 10.0 Rap1/GTP -0.015 0.091 0.248 1.0 -0.251 13.0 14.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.036 0.104 -9999.0 0.0 -0.227 53.0 53.0 CCND1 -0.038 0.094 0.166 1.0 -0.229 80.0 81.0 VAV2 -0.068 0.183 -9999.0 0.0 -0.533 14.0 14.0 RAP1/GDP -0.02 0.101 0.264 1.0 -0.257 18.0 19.0 adherens junction assembly -0.078 0.171 -9999.0 0.0 -0.39 85.0 85.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.033 0.036 -9999.0 0.0 -0.42 3.0 3.0 regulation of heterotypic cell-cell adhesion 0.028 0.106 -9999.0 0.0 -0.219 62.0 62.0 E-cadherin/beta catenin -0.024 0.102 -9999.0 0.0 -0.286 63.0 63.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.081 0.175 -9999.0 0.0 -0.401 87.0 87.0 PIK3CA 0.033 0.022 -9999.0 0.0 -0.42 1.0 1.0 Rac1/GTP -0.076 0.128 -9999.0 0.0 -0.381 31.0 31.0 E-cadherin/beta catenin/alpha catenin 0.02 0.102 -9999.0 0.0 -0.254 56.0 56.0 ITGAE 0.028 0.046 -9999.0 0.0 -0.42 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.076 0.187 -9999.0 0.0 -0.358 144.0 144.0