Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.039 0.051 0.305 7.0 -9999.0 0.0 7.0 KIRREL 0.025 0.057 -9999.0 0.0 -0.426 7.0 7.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.04 0.051 -9999.0 0.0 -0.306 7.0 7.0 PLCG1 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.029 0.054 -9999.0 0.0 -0.42 7.0 7.0 Nephrin/NEPH1/podocin/CD2AP 0.065 0.059 -9999.0 0.0 -0.236 7.0 7.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.022 0.045 -9999.0 0.0 -0.21 13.0 13.0 FYN 0.057 0.101 0.28 66.0 -0.207 13.0 79.0 mol:Ca2+ 0.059 0.057 -9999.0 0.0 -0.234 7.0 7.0 mol:DAG 0.06 0.058 -9999.0 0.0 -0.235 7.0 7.0 NPHS2 0.03 0.03 -9999.0 0.0 -0.428 1.0 1.0 mol:IP3 0.06 0.058 -9999.0 0.0 -0.235 7.0 7.0 regulation of endocytosis 0.046 0.057 -9999.0 0.0 -0.199 12.0 12.0 Nephrin/NEPH1/podocin/Cholesterol 0.049 0.049 -9999.0 0.0 -0.232 7.0 7.0 establishment of cell polarity 0.039 0.051 -9999.0 0.0 -0.305 7.0 7.0 Nephrin/NEPH1/podocin/NCK1-2 0.076 0.065 -9999.0 0.0 -0.22 8.0 8.0 Nephrin/NEPH1/beta Arrestin2 0.051 0.06 -9999.0 0.0 -0.201 12.0 12.0 NPHS1 0.041 0.03 -9999.0 0.0 -0.384 1.0 1.0 Nephrin/NEPH1/podocin 0.048 0.057 -9999.0 0.0 -0.207 13.0 13.0 TJP1 0.032 0.036 -9999.0 0.0 -0.42 3.0 3.0 NCK1 0.034 0.021 -9999.0 0.0 -0.42 1.0 1.0 NCK2 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.061 0.059 -9999.0 0.0 -0.236 7.0 7.0 CD2AP 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.061 0.059 -9999.0 0.0 -0.236 7.0 7.0 GRB2 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.057 0.104 0.284 67.0 -0.221 11.0 78.0 cytoskeleton organization 0.023 0.069 0.234 31.0 -0.25 7.0 38.0 Nephrin/NEPH1 0.035 0.037 -9999.0 0.0 -0.209 7.0 7.0 Nephrin/NEPH1/ZO-1 0.051 0.056 -9999.0 0.0 -0.251 10.0 10.0