Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.04 0.194 -9999.0 0.0 -0.585 53.0 53.0 IHH 0.017 0.088 -9999.0 0.0 -0.319 19.0 19.0 SHH Np/Cholesterol/GAS1 -0.027 0.106 -9999.0 0.0 -0.235 101.0 101.0 LRPAP1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.027 0.105 0.233 101.0 -9999.0 0.0 101.0 SMO/beta Arrestin2 -0.022 0.17 -9999.0 0.0 -0.416 56.0 56.0 SMO -0.038 0.164 -9999.0 0.0 -0.364 88.0 88.0 AKT1 -0.015 0.157 -9999.0 0.0 -0.532 30.0 30.0 ARRB2 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.014 0.093 -9999.0 0.0 -0.42 22.0 22.0 ADRBK1 0.034 0.01 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.034 0.164 -9999.0 0.0 -0.359 88.0 88.0 STIL -0.006 0.135 0.195 77.0 -0.23 98.0 175.0 DHH N/PTCH2 0.052 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.001 0.12 -9999.0 0.0 -0.291 69.0 69.0 PIK3CA 0.033 0.022 -9999.0 0.0 -0.42 1.0 1.0 DHH 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.064 0.25 -9999.0 0.0 -0.727 56.0 56.0 determination of left/right symmetry -0.034 0.164 -9999.0 0.0 -0.359 88.0 88.0 PIK3R1 0.019 0.08 -9999.0 0.0 -0.42 16.0 16.0 skeletal system development -0.063 0.248 -9999.0 0.0 -0.719 56.0 56.0 IHH N/Hhip 0.035 0.065 -9999.0 0.0 -0.286 12.0 12.0 DHH N/Hhip 0.049 0.029 -9999.0 0.0 -0.3 3.0 3.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.034 0.164 -9999.0 0.0 -0.359 88.0 88.0 pancreas development 0.032 0.036 -9999.0 0.0 -0.419 3.0 3.0 HHAT -0.017 0.134 -9999.0 0.0 -0.42 50.0 50.0 PI3K 0.036 0.065 -9999.0 0.0 -0.3 17.0 17.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.03 0.158 -9999.0 0.0 -0.42 71.0 71.0 somite specification -0.034 0.164 -9999.0 0.0 -0.359 88.0 88.0 SHH Np/Cholesterol/PTCH1 -0.031 0.108 -9999.0 0.0 -0.234 102.0 102.0 SHH Np/Cholesterol/PTCH2 0.003 0.074 -9999.0 0.0 -0.23 44.0 44.0 SHH Np/Cholesterol/Megalin -0.055 0.138 -9999.0 0.0 -0.274 133.0 133.0 SHH -0.016 0.09 -9999.0 0.0 -0.3 46.0 46.0 catabolic process -0.025 0.124 -9999.0 0.0 -0.324 70.0 70.0 SMO/Vitamin D3 -0.019 0.153 0.199 42.0 -0.331 63.0 105.0 SHH Np/Cholesterol/Hhip 0.002 0.075 -9999.0 0.0 -0.23 45.0 45.0 LRP2 -0.096 0.205 -9999.0 0.0 -0.42 144.0 144.0 receptor-mediated endocytosis -0.071 0.175 -9999.0 0.0 -0.36 98.0 98.0 SHH Np/Cholesterol/BOC -0.007 0.085 -9999.0 0.0 -0.229 63.0 63.0 SHH Np/Cholesterol/CDO -0.007 0.083 -9999.0 0.0 -0.235 56.0 56.0 mesenchymal cell differentiation -0.001 0.074 0.229 45.0 -9999.0 0.0 45.0 mol:Vitamin D3 -0.007 0.133 0.201 62.0 -0.235 102.0 164.0 IHH N/PTCH2 0.037 0.06 -9999.0 0.0 -0.271 10.0 10.0 CDON 0.021 0.067 -9999.0 0.0 -0.42 11.0 11.0 IHH N/PTCH1 -0.005 0.132 -9999.0 0.0 -0.326 70.0 70.0 Megalin/LRPAP1 -0.049 0.158 -9999.0 0.0 -0.299 144.0 144.0 PTCH2 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.007 0.07 -9999.0 0.0 -0.227 46.0 46.0 PTCH1 -0.025 0.124 -9999.0 0.0 -0.325 70.0 70.0 HHIP 0.032 0.036 -9999.0 0.0 -0.42 3.0 3.0