Clinical Features Time to Death AGE PRIMARY.SITE.OF.DISEASE GENDER HISTOLOGICAL.TYPE PATHOLOGY.T PATHOLOGY.N PATHOLOGICSPREAD(M) NEOADJUVANT.THERAPY nMutated (%) nWild-Type logrank test_P logrank test_Q t-test_P t-test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q APC 88 (72%) 34 0.38223 1 0.6112 1 0.0045564 1 0.16027 1 0.02058 1 0.18562 1 0.95625 1 0.73775 1 0.34684 1 SMAD4 15 (12%) 107 0.45799 1 0.91492 1 1 1 0.78496 1 0.0074136 1 1 1 1 1 0.62935 1 0.15839 1 FAM123B 12 (10%) 110 0.38423 1 0.76716 1 0.76229 1 0.75998 1 0.87046 1 0.74364 1 0.61601 1 0.33882 1 1 1 FBXW7 19 (16%) 103 0.45799 1 0.31966 1 0.4553 1 0.44969 1 0.040229 1 0.66038 1 0.76607 1 0.20992 1 0.23478 1 KRAS 55 (45%) 67 0.06669 1 0.75572 1 0.01705 1 0.58605 1 0.048415 1 0.040097 1 0.54386 1 1 1 0.22093 1 TP53 72 (59%) 50 0.99844 1 0.24238 1 0.097404 1 0.095622 1 0.09864 1 0.63126 1 0.9635 1 0.75924 1 0.39902 1 NRAS 9 (7%) 113 0.088015 1 0.016456 1 1 1 0.73135 1 1 1 0.11839 1 0.58875 1 0.57776 1 0.37494 1 BRAF 10 (8%) 112 0.61003 1 0.26605 1 0.020792 1 1 1 0.00042956 0.381 0.45067 1 0.4971 1 0.59564 1 0.40813 1 ARID1A 14 (11%) 108 0.45799 1 0.12288 1 0.15099 1 0.26446 1 0.012386 1 0.23211 1 0.28165 1 0.35615 1 0.5266 1 KRTAP5-5 4 (3%) 118 NA NA 0.66919 1 1 1 1 1 0.42267 1 1 1 0.45342 1 1 1 0.1848 1 ZC3H13 14 (11%) 108 0.48519 1 0.54967 1 0.04252 1 0.26446 1 0.049675 1 0.24122 1 0.92148 1 0.35615 1 0.5266 1 TCF7L2 8 (7%) 114 0.70012 1 0.84011 1 0.13439 1 1 1 0.3604 1 0.52417 1 0.87089 1 0.18036 1 1 1 LRP1B 19 (16%) 103 0.51362 1 0.25976 1 0.4553 1 0.2063 1 0.035918 1 0.60752 1 0.81684 1 0.68877 1 0.58851 1 KIAA1804 10 (8%) 112 0.54345 1 0.25619 1 0.041434 1 0.74245 1 0.02213 1 0.74156 1 0.90055 1 1 1 1 1 KLK2 3 (2%) 119 NA NA 0.14587 1 0.081346 1 1 1 0.069561 1 1 1 0.74232 1 1 1 1 1 SMAD2 6 (5%) 116 0.57494 1 0.99083 1 0.22898 1 0.69922 1 0.52725 1 0.79918 1 0.24507 1 1 1 1 1 DMD 16 (13%) 106 0.39332 1 0.94942 1 0.17488 1 0.28342 1 0.10085 1 0.61814 1 0.092785 1 0.65939 1 0.57797 1 CSMD3 17 (14%) 105 0.35717 1 0.84573 1 0.79717 1 0.79328 1 0.01503 1 0.16613 1 0.92814 1 1 1 1 1 BAI3 11 (9%) 111 0.54345 1 0.48556 1 1 1 1 1 0.25476 1 0.65798 1 0.15208 1 0.59929 1 1 1 WBSCR17 8 (7%) 114 0.82816 1 0.39968 1 0.13608 1 0.46442 1 0.2633 1 0.86447 1 0.87089 1 1 1 1 1 EVC2 11 (9%) 111 0.70012 1 0.99681 1 0.20858 1 1 1 0.34024 1 0.51519 1 0.47191 1 1 1 0.43984 1 LIFR 10 (8%) 112 0.045983 1 0.83323 1 0.74668 1 0.51422 1 0.25753 1 0.74156 1 0.4971 1 1 1 1 1 OPCML 6 (5%) 116 0.57494 1 0.76228 1 0.034452 1 1 1 0.11786 1 0.3922 1 1 1 0.47311 1 1 1 CDC27 6 (5%) 116 0.75606 1 0.3669 1 0.40254 1 0.39993 1 0.40908 1 0.54281 1 0.24507 1 1 1 1 1 TUSC3 5 (4%) 117 0.70012 1 0.66154 1 0.6526 1 1 1 0.51041 1 0.49248 1 0.82237 1 1 1 0.22625 1 ATP10A 9 (7%) 113 0.54345 1 0.78592 1 0.7298 1 1 1 0.33058 1 0.57095 1 0.37139 1 0.59644 1 1 1 FAT4 15 (12%) 107 0.70012 1 0.94461 1 0.42036 1 1 1 0.72366 1 0.20593 1 0.44542 1 0.35793 1 0.5529 1 MAPK10 6 (5%) 116 0.70012 1 0.061774 1 0.69453 1 1 1 0.86725 1 0.072638 1 0.4081 1 0.012798 1 0.26593 1 SYNE1 25 (20%) 97 0.22176 1 0.73498 1 0.074806 1 0.65117 1 0.081208 1 0.023791 1 1 1 0.45626 1 0.099785 1 GPC6 7 (6%) 115 0.75606 1 0.9328 1 0.69785 1 1 1 0.40908 1 0.094261 1 0.84746 1 0.52809 1 1 1 FAT2 13 (11%) 109 0.61003 1 0.29579 1 1 1 0.2344 1 0.051796 1 0.85688 1 1 1 0.35873 1 0.49902 1 CDH9 8 (7%) 114 0.045983 1 0.33807 1 1 1 0.46442 1 1 1 0.6597 1 0.44576 1 0.57776 1 1 1 PIK3R1 5 (4%) 117 0.60843 1 0.36406 1 0.38416 1 0.64983 1 0.69194 1 0.012387 1 0.82237 1 1 1 1 1 C3ORF30 3 (2%) 119 NA NA 0.41101 1 0.58076 1 1 1 0.72391 1 0.66913 1 1 1 1 1 1 1 HCLS1 6 (5%) 116 0.70012 1 0.80964 1 0.085226 1 0.69922 1 0.052412 1 0.54281 1 0.5994 1 1 1 1 1 IL1RAPL2 6 (5%) 116 0.82816 1 0.72324 1 0.22898 1 0.69922 1 0.014735 1 1 1 0.8292 1 1 1 1 1 DPF2 4 (3%) 118 NA NA 0.59957 1 1 1 0.31134 1 0.42267 1 0.7196 1 1 1 1 1 1 1 ELF3 4 (3%) 118 0.82816 1 0.14753 1 0.6305 1 1 1 1 1 0.23479 1 1 1 1 1 0.1848 1 NRXN3 11 (9%) 111 0.65245 1 0.57732 1 0.010206 1 0.75716 1 0.011903 1 0.28495 1 0.59948 1 0.59564 1 0.43984 1 TRIM44 5 (4%) 117 0.70012 1 0.75625 1 0.16704 1 0.16235 1 0.0027892 1 0.0039404 1 0.82237 1 0.41231 1 0.018993 1 SESTD1 7 (6%) 115 0.54345 1 0.15614 1 0.23793 1 0.13487 1 0.39396 1 0.2164 1 0.84746 1 1 1 0.3039 1 CD180 6 (5%) 116 0.70012 1 0.88772 1 0.085226 1 1 1 0.22127 1 0.3922 1 0.8292 1 1 1 1 1 CTNNB1 7 (6%) 115 0.70012 1 0.15784 1 1 1 0.13487 1 0.46701 1 0.29366 1 0.13968 1 1 1 0.3039 1 CDH8 8 (7%) 114 0.75606 1 0.15511 1 0.7286 1 0.72221 1 0.91287 1 0.73862 1 0.87089 1 0.18036 1 1 1 NALCN 12 (10%) 110 0.44834 1 0.70402 1 0.76229 1 1 1 0.87046 1 0.74364 1 1 1 1 1 1 1 PCDH9 10 (8%) 112 0.17972 1 0.31651 1 1 1 0.51422 1 0.64559 1 0.61268 1 1 1 0.59564 1 1 1 ZCWPW2 5 (4%) 117 0.75606 1 0.29287 1 1 1 1 1 1 1 0.033958 1 0.51959 1 0.34515 1 0.22625 1 CDH12 9 (7%) 113 0.75606 1 0.4256 1 1 1 0.49377 1 0.68912 1 0.45067 1 0.10109 1 0.59644 1 1 1 PIK3CA 7 (6%) 115 0.57494 1 0.8278 1 0.017795 1 1 1 0.003958 1 1 1 0.4623 1 1 1 1 1 FZD3 5 (4%) 117 0.65245 1 0.39837 1 0.16704 1 1 1 0.045584 1 0.23479 1 0.82237 1 1 1 0.22625 1 DACH2 8 (7%) 114 0.70012 1 0.90555 1 0.7286 1 0.72221 1 0.76081 1 0.26091 1 0.569 1 1 1 1 1 TXNDC3 6 (5%) 116 0.75606 1 0.24188 1 0.085226 1 0.69922 1 0.17728 1 0.54281 1 1 1 1 1 1 1 BCHE 6 (5%) 116 0.75606 1 0.61398 1 0.40254 1 0.23818 1 0.40908 1 0.23878 1 0.4081 1 0.47311 1 1 1 ERBB2 4 (3%) 118 NA NA 0.2134 1 0.13033 1 0.13521 1 0.50698 1 0.49248 1 0.45342 1 1 1 1 1 ZSWIM3 5 (4%) 117 0.82816 1 0.15721 1 0.16704 1 1 1 0.32652 1 0.31446 1 0.41774 1 0.41231 1 1 1 TASP1 4 (3%) 118 0.82816 1 0.74673 1 0.31784 1 0.31134 1 0.29397 1 0.038574 1 0.45342 1 0.27101 1 0.1848 1 DNAH2 17 (14%) 105 0.35717 1 0.5064 1 0.019441 1 1 1 0.010347 1 0.87949 1 0.80779 1 1 1 0.59389 1 BANK1 6 (5%) 116 0.75606 1 0.076603 1 1 1 0.69922 1 1 1 0.54281 1 0.8292 1 1 1 1 1 CASP14 5 (4%) 117 0.82816 1 0.86688 1 0.38416 1 0.64983 1 0.78688 1 0.45826 1 0.036241 1 0.41231 1 1 1 CPXCR1 5 (4%) 117 0.57494 1 0.89643 1 1 1 0.16235 1 0.17843 1 0.45826 1 0.82237 1 1 1 1 1 P2RY10 4 (3%) 118 0.006924 1 0.74988 1 0.31784 1 1 1 0.29397 1 0.36938 1 0.29102 1 1 1 0.1848 1 SPATA8 3 (2%) 119 NA NA 0.49578 1 0.25537 1 0.074854 1 0.50698 1 1 1 0.74232 1 1 1 1 1 GAS2L2 3 (2%) 119 0.75606 1 0.22369 1 1 1 1 1 1 1 0.13374 1 1 1 1 1 1 1 GAB3 5 (4%) 117 0.82816 1 0.52678 1 0.16704 1 0.012538 1 0.32652 1 0.15766 1 0.51959 1 1 1 1 1 MCF2 7 (6%) 115 0.82816 1 0.46173 1 1 1 0.13487 1 0.091089 1 0.043092 1 0.4623 1 1 1 1 1 NRG1 8 (7%) 114 0.70012 1 0.26694 1 1 1 0.46442 1 1 1 0.52417 1 1 1 1 1 1 1 MAP7 6 (5%) 116 0.82816 1 0.59831 1 1 1 0.39993 1 0.075566 1 0.23878 1 0.8292 1 1 1 1 1 SORCS1 8 (7%) 114 1 1 0.1432 1 0.7286 1 1 1 0.58544 1 0.13517 1 0.87089 1 0.57776 1 1 1 DOCK2 11 (9%) 111 0.51362 1 0.59676 1 0.53164 1 1 1 0.20687 1 0.42869 1 0.72971 1 0.59929 1 1 1 HMCN1 15 (12%) 107 0.36758 1 0.60196 1 1 1 0.092358 1 0.52233 1 0.81342 1 0.71693 1 0.6437 1 0.5529 1 VCAN 10 (8%) 112 0.75606 1 0.9549 1 0.74668 1 0.74245 1 0.82608 1 0.38001 1 0.38812 1 0.59564 1 1 1 IFT80 6 (5%) 116 0.75606 1 0.18605 1 1 1 0.69922 1 0.59208 1 0.23878 1 0.24507 1 1 1 1 1 ZIM3 5 (4%) 117 0.006924 1 0.17064 1 0.066873 1 1 1 0.15443 1 0.077272 1 0.41774 1 1 1 1 1 CCBP2 6 (5%) 116 0.70012 1 0.64061 1 0.22898 1 0.69922 1 0.059484 1 0.10915 1 0.24507 1 1 1 1 1 LUZP2 3 (2%) 119 NA NA 0.86383 1 1 1 1 1 0.3945 1 0.66913 1 1 1 1 1 1 1 CYP19A1 6 (5%) 116 0.70012 1 0.95277 1 1 1 0.69922 1 0.075566 1 0.54281 1 0.5994 1 1 1 1 1 GFRA1 6 (5%) 116 0.70012 1 0.49103 1 0.22898 1 0.39993 1 0.12965 1 0.10915 1 0.8292 1 1 1 1 1 CTSO 5 (4%) 117 0.70012 1 0.08529 1 0.6526 1 0.39236 1 0.82711 1 1 1 0.82237 1 1 1 1 1 KCNB2 7 (6%) 115 0.006924 1 0.78039 1 0.46543 1 0.23666 1 0.26437 1 0.1889 1 0.63102 1 1 1 1 1 MGC42105 5 (4%) 117 NA NA 0.51625 1 0.16704 1 1 1 0.23721 1 0.60205 1 0.51959 1 1 1 1 1 CFHR5 4 (3%) 118 NA NA 0.87691 1 0.6305 1 0.31134 1 0.78688 1 0.7196 1 0.45342 1 1 1 1 1 ADAM18 4 (3%) 118 0.57494 1 0.42918 1 0.6305 1 1 1 0.15583 1 0.66913 1 1 1 1 1 0.1848 1 FAM133A 3 (2%) 119 NA NA 0.29773 1 1 1 1 1 0.3945 1 0.66913 1 0.74232 1 0.27101 1 1 1 RAD21 5 (4%) 117 0.82816 1 0.45119 1 0.6526 1 0.16235 1 0.068992 1 1 1 0.82237 1 1 1 1 1 BMPR2 6 (5%) 116 0.70012 1 0.4431 1 0.085226 1 1 1 0.17728 1 1 1 1 1 1 1 1 1 DPYD 7 (6%) 115 0.54345 1 0.17987 1 0.69453 1 0.041169 1 0.019991 1 0.54281 1 0.84746 1 1 1 0.3039 1 C4BPA 6 (5%) 116 0.54345 1 0.088215 1 0.38416 1 0.39993 1 0.11671 1 0.45826 1 0.24507 1 1 1 0.26593 1 F13A1 5 (4%) 117 NA NA 0.054333 1 0.6526 1 1 1 0.82711 1 0.31446 1 0.10094 1 0.41231 1 1 1 FREM2 10 (8%) 112 0.61003 1 0.3004 1 0.74668 1 0.32199 1 0.63876 1 0.38001 1 0.62338 1 0.59564 1 1 1 CDCP2 5 (4%) 117 0.82816 1 0.39277 1 0.6526 1 0.39236 1 0.82711 1 0.60205 1 0.82237 1 1 1 1 1 RNF219 5 (4%) 117 0.82816 1 0.049067 1 0.38416 1 0.64983 1 0.78688 1 0.15766 1 0.82237 1 1 1 1 1 OR5B12 4 (3%) 118 0.75606 1 0.60356 1 1 1 1 1 0.31561 1 0.088942 1 0.6189 1 1 1 1 1 FLRT2 7 (6%) 115 0.70012 1 0.32955 1 0.23793 1 1 1 0.39396 1 0.54281 1 0.4623 1 1 1 0.3039 1 EPHA5 7 (6%) 115 0.54345 1 0.29644 1 1 1 1 1 0.32747 1 0.47396 1 0.84746 1 1 1 1 1 ODZ1 10 (8%) 112 0.65245 1 0.59997 1 0.74668 1 0.0019834 1 0.11234 1 0.74156 1 0.14296 1 0.25868 1 1 1 SLC45A2 4 (3%) 118 NA NA 0.28941 1 1 1 0.13521 1 1 1 0.11168 1 1 1 0.34515 1 1 1 C14ORF106 6 (5%) 116 0.57494 1 0.21116 1 0.6526 1 0.39993 1 0.51041 1 1 1 0.8292 1 1 1 1 1 KCNT2 7 (6%) 115 0.60843 1 0.11845 1 0.46543 1 0.041169 1 0.21221 1 0.40367 1 0.84746 1 1 1 1 1 MAGEC2 5 (4%) 117 NA NA 0.65402 1 1 1 0.16235 1 0.38153 1 1 1 0.82237 1 1 1 1 1 CWF19L2 5 (4%) 117 0.75606 1 0.72209 1 1 1 0.39236 1 0.022654 1 0.0035259 1 0.82237 1 1 1 1 1