rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(104), AXIN1(1), AXIN2(5), BTRC(3), CACYBP(1), CAMK2D(2), CCND2(1), CCND3(1), CHD8(2), CREBBP(8), CSNK2A2(1), CTNNB1(8), CUL1(5), DAAM1(1), DAAM2(4), DKK1(2), DKK2(3), DKK4(3), DVL2(2), DVL3(2), EP300(8), FBXW11(4), FZD1(1), FZD10(2), FZD2(1), FZD3(7), FZD4(1), FZD6(4), FZD7(1), GSK3B(2), LEF1(1), LRP5(3), LRP6(8), MAP3K7(2), MAPK10(6), MAPK8(6), MAPK9(2), MMP7(2), NFATC1(1), NFATC2(3), NFATC3(1), NFATC4(2), NKD1(1), PLCB1(1), PLCB3(3), PLCB4(2), PPARD(1), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(1), PPP2R2B(2), PPP2R2C(2), PPP3CA(2), PPP3CB(2), PPP3CC(3), PRICKLE1(5), PRICKLE2(3), PRKACA(1), PRKACG(1), PRKCA(3), PRKCG(5), RBX1(1), RHOA(1), ROCK1(8), ROCK2(4), RUVBL1(4), SENP2(2), SFRP1(2), SFRP2(2), SFRP4(1), SIAH1(1), SMAD2(6), SMAD3(3), SMAD4(15), TBL1X(1), TBL1Y(1), TCF7(5), TCF7L1(1), TCF7L2(8), TP53(73), VANGL1(1), VANGL2(1), WIF1(1), WNT10B(1), WNT11(1), WNT16(1), WNT2(1), WNT2B(2), WNT3(1), WNT4(1), WNT6(1), WNT8A(1), WNT9B(2)	28815720	423	119	360	61	118	101	63	5	109	27	<1.00e-15	<1.28e-14
2	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	201	ABI2(1), ACTN1(2), ACTN2(5), ACTN3(1), ACTN4(3), APC(104), ARAF(1), ARHGEF1(2), ARHGEF12(2), ARHGEF4(2), ARHGEF6(3), ARHGEF7(3), ARPC1B(1), ARPC2(1), ARPC5L(2), BAIAP2(1), BDKRB2(1), BRAF(10), CDC42(1), CHRM1(1), CHRM2(3), CHRM4(1), CHRM5(2), CSK(2), CYFIP1(3), CYFIP2(1), DIAPH2(6), DIAPH3(2), DOCK1(2), EGFR(5), F2(2), FGD1(3), FGD3(1), FGF11(1), FGF12(1), FGF13(1), FGF14(2), FGF19(1), FGF20(1), FGF3(1), FGF5(2), FGFR1(1), FGFR2(5), FN1(6), GIT1(1), GRLF1(5), IQGAP1(8), IQGAP2(8), IQGAP3(4), ITGA1(1), ITGA10(4), ITGA11(2), ITGA2(2), ITGA2B(3), ITGA4(5), ITGA5(2), ITGA6(2), ITGA8(3), ITGA9(3), ITGAD(2), ITGAE(3), ITGAL(4), ITGAM(3), ITGAV(4), ITGAX(2), ITGB2(2), ITGB3(2), ITGB4(1), ITGB5(4), ITGB6(2), ITGB7(2), ITGB8(1), KRAS(55), LIMK1(2), LIMK2(1), MAP2K1(2), MAP2K2(1), MAPK3(1), MOS(1), MRAS(1), MSN(3), MYH10(6), MYH14(3), MYH9(6), MYL9(2), MYLK(5), MYLK2(2), NCKAP1(3), NCKAP1L(6), NRAS(9), PAK1(1), PAK2(3), PAK3(3), PAK7(3), PDGFRA(4), PDGFRB(2), PIK3CA(7), PIK3CB(1), PIK3CD(2), PIK3CG(5), PIK3R1(6), PIK3R3(4), PIP4K2C(1), PIP5K1B(1), PIP5K1C(3), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP1R12B(4), PTK2(1), RAF1(4), RDX(1), RHOA(1), ROCK1(8), ROCK2(4), RRAS2(1), SCIN(1), SLC9A1(2), SOS1(3), SOS2(6), SSH1(2), SSH2(1), SSH3(1), TIAM1(6), TIAM2(5), VAV1(7), VAV2(3), VAV3(3), VCL(2), WASF1(2), WASF2(1), WASL(2)	51109242	516	116	433	111	120	186	79	4	99	28	<1.00e-15	<1.28e-14
3	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	246	ACVR1B(3), ACVR1C(1), AKT1(1), AKT2(2), AKT3(1), ATF2(1), ATF4(1), BRAF(10), CACNA1A(9), CACNA1B(4), CACNA1C(2), CACNA1D(3), CACNA1E(6), CACNA1F(5), CACNA1I(2), CACNA1S(7), CACNA2D1(6), CACNA2D3(3), CACNB2(2), CACNB3(1), CACNB4(2), CACNG1(1), CACNG2(1), CACNG3(3), CACNG6(1), CACNG7(3), CACNG8(1), CASP3(1), CDC25B(2), CDC42(1), CHUK(4), DAXX(1), DUSP1(2), DUSP10(3), DUSP16(4), DUSP3(1), DUSP5(2), DUSP6(3), DUSP7(2), ECSIT(1), EGFR(5), ELK4(1), FAS(2), FGF11(1), FGF12(1), FGF13(1), FGF14(2), FGF19(1), FGF20(1), FGF3(1), FGF5(2), FGFR1(1), FGFR2(5), FLNA(1), FLNB(6), FLNC(2), FOS(1), GRB2(2), IKBKB(2), IL1B(1), IL1R1(1), IL1R2(5), KRAS(55), MAP2K1(2), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K5(2), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K12(2), MAP3K13(1), MAP3K14(1), MAP3K2(1), MAP3K3(2), MAP3K4(8), MAP3K5(3), MAP3K6(2), MAP3K7(2), MAP3K8(1), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(3), MAPK10(6), MAPK13(1), MAPK3(1), MAPK8(6), MAPK8IP3(1), MAPK9(2), MAPT(1), MEF2C(2), MKNK1(1), MKNK2(1), MOS(1), MRAS(1), NF1(5), NFATC2(3), NFATC4(2), NFKB1(4), NFKB2(2), NR4A1(2), NRAS(9), NTRK1(3), NTRK2(1), PAK1(1), PAK2(3), PDGFRA(4), PDGFRB(2), PLA2G4A(4), PLA2G6(2), PPM1B(2), PPP3CA(2), PPP3CB(2), PPP3CC(3), PPP5C(1), PRKACA(1), PRKACG(1), PRKCA(3), PRKCG(5), PTPN7(2), PTPRR(4), RAF1(4), RAP1A(1), RAP1B(1), RAPGEF2(5), RASA1(5), RASA2(2), RASGRF1(6), RASGRF2(4), RASGRP1(3), RASGRP2(2), RASGRP3(3), RASGRP4(1), RPS6KA2(4), RPS6KA3(2), RPS6KA5(4), RPS6KA6(3), RRAS2(1), SOS1(3), SOS2(6), STMN1(1), TAOK1(2), TAOK2(1), TGFB1(1), TGFB2(4), TGFBR1(5), TGFBR2(2), TP53(73), TRAF6(1), ZAK(2)	53006312	502	115	413	125	163	169	102	6	57	5	<1.00e-15	<1.28e-14
4	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(1), APC(104), AR(3), ASAH1(1), BRAF(10), DAG1(3), EGFR(5), GNA11(1), GNA15(1), GNAI1(1), GNAQ(1), ITPR1(8), ITPR2(6), ITPR3(7), KCNJ5(1), KCNJ9(2), MAPK10(6), PHKA2(3), PIK3CA(7), PIK3CD(2), PIK3R1(6), PTX3(2), RAF1(4), SRC(3)	9838080	188	101	156	21	34	30	29	0	66	29	<1.00e-15	<1.28e-14
5	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(3), APC(104), ATF2(1), AXIN1(1), BMP10(1), BMP2(1), BMP4(2), BMP5(3), BMP7(2), BMPR1A(1), BMPR2(8), CTNNB1(8), FZD1(1), GSK3B(2), MAP3K7(2), MEF2C(2), NPPB(1), RFC1(4), TGFB1(1), TGFB2(4), TGFBR1(5), TGFBR2(2), TGFBR3(3)	6473550	162	100	136	8	22	30	15	0	69	26	<1.00e-15	<1.28e-14
6	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(104), AXIN1(1), CCND2(1), CCND3(1), CTNNB1(8), DVL2(2), DVL3(2), FBXW2(1), FZD1(1), FZD10(2), FZD2(1), FZD3(7), FZD6(4), FZD7(1), GSK3B(2), LDLR(1), MAPK10(6), MAPK9(2), PLAU(1), PPP2R5C(1), PPP2R5E(2), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCI(1), PRKCQ(2), PRKD1(5), RHOA(1), SFRP4(1), TCF7(5), WNT10B(1), WNT11(1), WNT16(1), WNT2(1), WNT2B(2), WNT3(1), WNT4(1), WNT6(1)	10472464	186	100	161	22	28	41	19	0	72	26	<1.00e-15	<1.28e-14
7	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(2), ABLIM1(4), ABLIM3(2), ARHGEF12(2), CDC42(1), CXCR4(1), DCC(5), DPYSL2(4), DPYSL5(1), EFNA5(3), EFNB2(1), EFNB3(1), EPHA1(4), EPHA2(2), EPHA3(7), EPHA4(3), EPHA5(9), EPHA7(4), EPHA8(3), EPHB1(3), EPHB2(3), EPHB3(1), EPHB4(4), FYN(1), GNAI1(1), GSK3B(2), KRAS(55), L1CAM(2), LIMK1(2), LIMK2(1), LRRC4C(3), MAPK3(1), MET(1), NCK1(1), NFATC1(1), NFATC2(3), NFATC3(1), NFATC4(2), NRAS(9), NRP1(1), NTN1(2), NTN4(2), NTNG1(3), PAK1(1), PAK2(3), PAK3(3), PAK7(3), PLXNA2(5), PLXNA3(1), PLXNB1(2), PLXNB3(1), PLXNC1(3), PPP3CA(2), PPP3CB(2), PPP3CC(3), PTK2(1), RASA1(5), RGS3(3), RHOA(1), ROBO1(9), ROBO2(3), ROBO3(3), ROCK1(8), ROCK2(4), SEMA3A(4), SEMA3C(1), SEMA3D(5), SEMA3E(6), SEMA3G(1), SEMA4A(2), SEMA4B(1), SEMA4D(4), SEMA4F(5), SEMA4G(4), SEMA5A(5), SEMA5B(5), SEMA6B(2), SEMA6C(2), SEMA6D(5), SEMA7A(2), SLIT1(3), SLIT2(4), SLIT3(4), SRGAP1(2), SRGAP3(1), UNC5A(1), UNC5B(1), UNC5C(4)	35300578	304	99	253	73	100	122	49	3	30	0	<1.00e-15	<1.28e-14
8	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(104), AXIN1(1), CREBBP(8), CTNNB1(8), EP300(8), FZD1(1), GSK3B(2), HDAC1(2), LDB1(2), LEF1(1), TRRAP(9)	5920936	146	98	121	6	19	22	15	1	63	26	<1.00e-15	<1.28e-14
9	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), AKT2(2), AKT3(1), APC(104), AXIN1(1), AXIN2(5), CTNNB1(8), DACT1(1), DKK1(2), DKK2(3), DKK3(1), DKK4(3), FSTL1(2), GSK3B(2), LRP1(7), MVP(3), NKD1(1), PIN1(1), PTPRA(1), SENP2(2), SFRP1(2), TSHB(1), WIF1(1)	7337384	155	98	130	8	20	25	24	0	60	26	<1.00e-15	<1.28e-14
10	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(1), APC(104), AXIN1(1), CTNNB1(8), FZD1(1), GJA1(4), GNAI1(1), GSK3B(2), LEF1(1), MYD88(1), NFKB1(4), PDPK1(1), PIK3CA(7), PIK3R1(6), PPP2CA(1), TLR4(4), TOLLIP(1)	5399076	148	96	123	9	19	21	20	0	60	28	<1.00e-15	<1.28e-14
11	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(1), APC(104), ASAH1(1), CAV3(1), DAG1(3), DLG4(1), EPHB2(3), GNAI1(1), GNAQ(1), ITPR1(8), ITPR2(6), ITPR3(7), KCNJ5(1), KCNJ9(2), PTX3(2), RHO(2), RYR1(11)	8542008	156	96	131	18	27	27	12	0	63	27	<1.00e-15	<1.28e-14
12	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(104), AXIN1(1), BTRC(3), CREBBP(8), CSNK1D(2), CTNNB1(8), FZD1(1), GSK3B(2), HDAC1(2), MAP3K7(2), PPARD(1), PPP2CA(1), WIF1(1)	5268794	136	96	111	6	14	17	16	0	63	26	<1.00e-15	<1.28e-14
13	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(2), AKT1(1), AKT2(2), AKT3(1), APAF1(2), ATM(15), BID(1), BIRC2(2), BIRC3(5), CAPN2(2), CASP10(1), CASP3(1), CASP6(2), CASP7(1), CASP8(5), CASP9(1), CFLAR(1), CHUK(4), CSF2RB(1), DFFA(2), DFFB(1), FAS(2), IKBKB(2), IL1B(1), IL1R1(1), IL1RAP(1), IL3(1), IRAK3(2), IRAK4(2), MAP3K14(1), MYD88(1), NFKB1(4), NFKB2(2), NTRK1(3), PIK3CA(7), PIK3CB(1), PIK3CD(2), PIK3CG(5), PIK3R1(6), PIK3R3(4), PPP3CA(2), PPP3CB(2), PPP3CC(3), PRKACA(1), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), TNFRSF10B(4), TNFRSF10D(1), TP53(73)	15199916	194	95	163	33	68	56	31	2	34	3	<1.00e-15	<1.28e-14
14	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(104), CDH1(2), CREBBP(8), EP300(8), MAP2K1(2), MAP3K7(2), MAPK3(1), SKIL(1), TGFB1(1), TGFB2(4), TGFBR1(5), TGFBR2(2)	4733652	140	95	115	8	12	19	13	1	69	26	<1.00e-15	<1.28e-14
15	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(2), ABL2(3), AKT1(1), AKT2(2), AKT3(1), ARAF(1), BRAF(10), CAMK2D(2), CBL(4), CBLB(3), CDKN1A(1), CDKN1B(2), EGFR(5), ERBB2(4), ERBB3(6), ERBB4(7), EREG(1), GAB1(1), GRB2(2), GSK3B(2), KRAS(55), MAP2K1(2), MAP2K2(1), MAP2K4(2), MAPK10(6), MAPK3(1), MAPK8(6), MAPK9(2), NCK1(1), NRAS(9), NRG1(9), NRG2(3), NRG3(5), PAK1(1), PAK2(3), PAK3(3), PAK7(3), PIK3CA(7), PIK3CB(1), PIK3CD(2), PIK3CG(5), PIK3R1(6), PIK3R3(4), PLCG1(1), PLCG2(4), PRKCA(3), PRKCG(5), PTK2(1), RAF1(4), RPS6KB2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SOS1(3), SOS2(6), SRC(3), STAT5B(1)	18690782	233	94	171	44	48	105	50	3	25	2	<1.00e-15	<1.28e-14
16	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(15), CCNA1(3), CCND2(1), CCND3(1), CCNE1(1), CCNE2(1), CCNH(1), CDC25A(1), CDK4(1), CDKN1A(1), CDKN1B(2), CREB3(2), CREB3L3(2), E2F3(2), GBA2(1), MCM3(2), MCM4(1), MCM5(5), MCM6(1), MCM7(2), MNAT1(1), MYT1(9), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(1), POLA2(2), POLE(10), POLE2(1), RB1(3), RBL1(4), TFDP1(1), TNXB(4), TP53(73)	13516190	159	93	127	26	57	45	22	3	31	1	<1.00e-15	<1.28e-14
17	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(2), ATM(15), ATR(7), BID(1), CASP3(1), CASP8(5), CASP9(1), CCNB2(1), CCNB3(6), CCND2(1), CCND3(1), CCNE1(1), CCNE2(1), CCNG1(1), CDK4(1), CDKN1A(1), CHEK2(1), DDB2(1), EI24(1), FAS(2), GTSE1(2), IGF1(1), IGFBP3(3), MDM4(1), PTEN(4), RFWD2(2), SERPINB5(2), SERPINE1(3), SESN1(1), SESN2(2), SESN3(2), SIAH1(1), THBS1(3), TNFRSF10B(4), TP53(73), TP53I3(2), TSC2(1), ZMAT3(2)	11551488	160	93	129	24	57	52	22	2	26	1	<1.00e-15	<1.28e-14
18	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(3), APC(104), AXIN1(1), BTRC(3), CTNNB1(8), DLL1(3), FZD1(1), GSK3B(2)	3440306	125	93	100	2	10	15	11	0	63	26	<1.00e-15	<1.28e-14
19	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	129	ACTN1(2), ACTN2(5), ACTN3(1), ACTN4(3), AKT1(1), AKT2(2), AKT3(1), AMOTL1(3), ASH1L(11), CASK(2), CDC42(1), CDK4(1), CGN(2), CLDN10(3), CLDN16(2), CLDN17(3), CLDN2(1), CLDN8(2), CSDA(1), CSNK2A2(1), CTNNA1(5), CTNNA2(2), CTNNA3(1), CTNNB1(8), CTTN(1), EPB41L1(5), EPB41L2(3), EPB41L3(6), EXOC4(4), GNAI1(1), HCLS1(6), IGSF5(6), INADL(2), KRAS(55), LLGL2(2), MAGI1(6), MAGI2(7), MAGI3(3), MLLT4(3), MPDZ(4), MRAS(1), MYH1(8), MYH10(6), MYH11(12), MYH13(5), MYH14(3), MYH15(4), MYH2(5), MYH3(7), MYH4(4), MYH6(5), MYH7(5), MYH7B(2), MYH8(7), MYH9(6), MYL9(2), NRAS(9), PARD3(4), PARD6A(2), PARD6G(1), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(1), PPP2R2B(2), PPP2R2C(2), PPP2R3A(4), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCI(1), PRKCQ(2), PTEN(4), RHOA(1), RRAS2(1), SPTAN1(7), SRC(3), TJAP1(1), TJP1(2), TJP2(2), ZAK(2)	35435936	326	92	273	78	107	142	42	0	34	1	<1.00e-15	<1.28e-14
20	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(5), ACACB(5), AKT1(1), AKT2(2), AKT3(1), ARAF(1), BRAF(10), CBL(4), CBLB(3), EXOC7(2), FBP2(1), G6PC(1), G6PC2(1), GCK(1), GRB2(2), GSK3B(2), GYS1(2), GYS2(4), IKBKB(2), INPP5D(2), INSR(1), IRS1(4), IRS4(8), KRAS(55), LIPE(1), MAP2K1(2), MAP2K2(1), MAPK10(6), MAPK3(1), MAPK8(6), MAPK9(2), MKNK1(1), MKNK2(1), NRAS(9), PCK1(3), PCK2(2), PDE3A(1), PDE3B(1), PDPK1(1), PFKM(3), PFKP(2), PHKA1(5), PHKA2(3), PHKB(2), PHKG2(2), PIK3CA(7), PIK3CB(1), PIK3CD(2), PIK3CG(5), PIK3R1(6), PIK3R3(4), PPP1CB(1), PPP1CC(1), PPP1R3A(6), PPP1R3C(2), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKACA(1), PRKACG(1), PRKAG2(2), PRKAG3(3), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), PRKCI(1), PTPN1(4), PTPRF(5), PYGB(1), PYGM(3), RAF1(4), RAPGEF1(2), RPS6KB2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SLC2A4(2), SOCS2(1), SOCS4(1), SORBS1(7), SOS1(3), SOS2(6), TSC1(2), TSC2(1)	28459248	277	92	219	65	69	117	59	2	28	2	<1.00e-15	<1.28e-14
21	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(104), ASAH1(1), CASP3(1), CERK(1), CREB3(2), CREB5(2), DAG1(3), EPHB2(3), FOS(1), GNAQ(1), MAP2K4(2), MAPK10(6), MAPK8(6), MAPK8IP3(1), MAPK9(2)	4935958	136	92	111	5	13	15	14	2	66	26	<1.00e-15	<1.28e-14
22	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	125	ARAF(1), BID(1), BRAF(10), CASP3(1), FAS(2), FCGR3A(1), FYN(1), GRB2(2), GZMB(2), HLA-A(2), HLA-B(1), HLA-G(1), IFNA10(3), IFNA2(2), IFNA5(1), IFNAR2(1), IFNGR1(1), IFNGR2(1), ITGAL(4), ITGB2(2), KIR2DL1(2), KIR2DL4(1), KIR3DL1(1), KIR3DL2(1), KLRC3(1), KRAS(55), LAT(1), LCK(2), LCP2(1), MAP2K1(2), MAP2K2(1), MAPK3(1), MICB(2), NFATC1(1), NFATC2(3), NFATC3(1), NFATC4(2), NRAS(9), PAK1(1), PIK3CA(7), PIK3CB(1), PIK3CD(2), PIK3CG(5), PIK3R1(6), PIK3R3(4), PLCG1(1), PLCG2(4), PPP3CA(2), PPP3CB(2), PPP3CC(3), PRKCA(3), PRKCG(5), PTK2B(1), PTPN11(4), RAF1(4), SH2D1A(1), SH3BP2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SOS1(3), SOS2(6), SYK(3), TNFRSF10B(4), TNFRSF10D(1), TYROBP(1), VAV1(7), VAV2(3), VAV3(3), ZAP70(1)	20348864	220	91	162	46	47	105	42	0	24	2	<1.00e-15	<1.28e-14
23	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(5), ADCY2(8), ADCY3(2), ADCY4(2), ADCY5(6), ADCY7(2), ADCY8(3), ADCY9(2), CAMK2D(2), CREB3(2), CREB3L2(1), CREB3L3(2), CREBBP(8), CTNNB1(8), DCT(7), DVL2(2), DVL3(2), EDNRB(5), EP300(8), FZD1(1), FZD10(2), FZD2(1), FZD3(7), FZD4(1), FZD6(4), FZD7(1), GNAI1(1), GNAO1(2), GNAQ(1), GNAS(2), GSK3B(2), KIT(2), KITLG(1), KRAS(55), LEF1(1), MAP2K1(2), MAP2K2(1), MAPK3(1), MITF(3), NRAS(9), PLCB1(1), PLCB3(3), PLCB4(2), PRKACA(1), PRKACG(1), PRKCA(3), PRKCG(5), RAF1(4), TCF7(5), TCF7L1(1), TCF7L2(8), TYR(1), TYRP1(1), WNT10B(1), WNT11(1), WNT16(1), WNT2(1), WNT2B(2), WNT3(1), WNT4(1), WNT6(1), WNT8A(1), WNT9B(2)	19539296	225	90	174	64	60	115	29	3	18	0	<1.00e-15	<1.28e-14
24	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(15), ATR(7), BRCA1(2), CDC25A(1), CDC25B(2), CDC25C(1), CDKN1A(1), CHEK2(1), EP300(8), MYT1(9), PRKDC(5), TP53(73), YWHAH(1)	7939148	126	89	95	11	49	35	16	4	21	1	<1.00e-15	<1.28e-14
25	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(5), ADCY8(3), ARAF(1), ATF4(1), BRAF(10), CACNA1C(2), CAMK2D(2), CAMK4(1), CREBBP(8), EP300(8), GNAQ(1), GRIA1(6), GRIA2(6), GRIN1(1), GRIN2A(9), GRIN2B(3), GRIN2C(2), GRIN2D(2), GRM1(5), GRM5(4), ITPR1(8), ITPR2(6), ITPR3(7), KRAS(55), MAP2K1(2), MAP2K2(1), MAPK3(1), NRAS(9), PLCB1(1), PLCB3(3), PLCB4(2), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP3CA(2), PPP3CB(2), PPP3CC(3), PRKACA(1), PRKACG(1), PRKCA(3), PRKCG(5), RAF1(4), RAP1A(1), RAP1B(1), RAPGEF3(3), RPS6KA2(4), RPS6KA3(2), RPS6KA6(3)	18740816	213	89	155	49	54	97	43	2	15	2	<1.00e-15	<1.28e-14
26	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(5), ADCY2(8), ADCY3(2), ADCY4(2), ADCY5(6), ADCY7(2), ADCY8(3), ADCY9(2), ATF4(1), CACNA1C(2), CACNA1D(3), CACNA1F(5), CACNA1S(7), CAMK2D(2), CDC42(1), CGA(1), EGFR(5), FSHB(2), GNA11(1), GNAQ(1), GNAS(2), GRB2(2), ITPR1(8), ITPR2(6), ITPR3(7), KRAS(55), MAP2K1(2), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K2(1), MAP3K3(2), MAP3K4(8), MAPK10(6), MAPK13(1), MAPK3(1), MAPK8(6), MAPK9(2), MMP14(1), MMP2(3), NRAS(9), PLA2G4A(4), PLA2G6(2), PLCB1(1), PLCB3(3), PLCB4(2), PLD1(6), PLD2(1), PRKACA(1), PRKACG(1), PRKCA(3), PTK2B(1), RAF1(4), SOS1(3), SOS2(6), SRC(3)	23758600	234	89	183	60	61	111	35	3	23	1	<1.00e-15	<1.28e-14
27	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(1), ATF2(1), CDC42(1), DLD(1), DUSP10(3), GAB1(1), GCK(1), IL1R1(1), MAP2K4(2), MAP2K5(2), MAP3K1(2), MAP3K10(1), MAP3K11(1), MAP3K12(2), MAP3K13(1), MAP3K2(1), MAP3K3(2), MAP3K4(8), MAP3K5(3), MAP3K7(2), MAP3K9(4), MAPK10(6), MAPK8(6), MAPK9(2), MYEF2(2), NFATC3(1), NR2C2(1), PAPPA(10), SHC1(1), TP53(73), TRAF6(1), ZAK(2)	9079386	146	89	115	20	58	31	23	3	31	0	<1.00e-15	<1.28e-14
28	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(2), ATM(15), ATR(7), CCNA1(3), CCNE1(1), CDC25A(1), CDK4(1), CDKN1A(1), CDKN1B(2), DHFR(1), GSK3B(2), HDAC1(2), RB1(3), TFDP1(1), TGFB1(1), TGFB2(4), TP53(73)	5482958	120	87	89	11	45	31	16	2	25	1	<1.00e-15	<1.28e-14
29	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	AKT1(1), AKT2(2), AKT3(1), BCL10(1), CARD11(5), CBL(4), CBLB(3), CD28(1), CD40LG(4), CDC42(1), CDK4(1), CHUK(4), CTLA4(1), FOS(1), FYN(1), GRAP2(4), GRB2(2), IKBKB(2), IL10(1), IL2(2), IL4(1), ITK(4), KRAS(55), LAT(1), LCK(2), LCP2(1), MALT1(2), MAP3K14(1), MAP3K8(1), NCK1(1), NFATC1(1), NFATC2(3), NFATC3(1), NFATC4(2), NFKB1(4), NFKB2(2), NRAS(9), PAK1(1), PAK2(3), PAK3(3), PAK7(3), PDK1(2), PIK3CA(7), PIK3CB(1), PIK3CD(2), PIK3CG(5), PIK3R1(6), PIK3R3(4), PLCG1(1), PPP3CA(2), PPP3CB(2), PPP3CC(3), PRKCQ(2), PTPRC(9), RASGRP1(3), RHOA(1), SOS1(3), SOS2(6), TEC(2), VAV1(7), VAV2(3), VAV3(3), ZAP70(1)	18422536	218	87	166	37	53	114	33	0	16	2	<1.00e-15	<1.28e-14
30	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(15), CDC25A(1), CDC25B(2), CDC25C(1), CDK4(1), MYT1(9), RB1(3), TP53(73), YWHAH(1)	3273608	106	87	75	5	43	26	12	3	21	1	<1.00e-15	<1.28e-14
31	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	67	APAF1(2), BCL2L11(2), BID(1), BIRC2(2), BIRC3(5), BNIP3L(2), CASP10(1), CASP2(1), CASP3(1), CASP4(2), CASP6(2), CASP7(1), CASP8(5), CASP9(1), CHUK(4), DFFA(2), DFFB(1), FAS(2), GZMB(2), HELLS(2), IKBKB(2), IRF3(2), IRF4(2), MAP2K4(2), MAP3K1(2), MAPK10(6), NFKB1(4), TNFRSF10B(4), TNFRSF21(2), TP53(73), TRAF1(1), TRAF3(2)	10272486	143	86	112	27	54	34	21	2	32	0	<1.00e-15	<1.28e-14
32	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(15), ATR(7), BRCA1(2), BRCA2(13), CHEK2(1), FANCA(5), FANCC(1), FANCD2(5), FANCF(1), FANCG(3), MRE11A(5), RAD17(2), RAD50(7), TP53(73), TREX1(1)	8102966	141	86	110	8	49	45	22	2	22	1	<1.00e-15	<1.28e-14
33	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(1), BTK(2), CAD(4), CASP10(1), CASP3(1), CASP8(5), CASP8AP2(6), DAXX(1), DEDD(1), DFFA(2), EGFR(5), EPHB2(3), FAF1(3), IL8(1), MAP2K4(2), MAP3K1(2), MAP3K5(3), MAPK10(6), MAPK8(6), MAPK8IP3(1), MAPK9(2), MET(1), NFKB1(4), NFKB2(2), PTPN13(9), RALBP1(2), ROCK1(8), TP53(73), TPX2(3)	13191296	160	86	129	28	55	46	27	3	29	0	<1.00e-15	<1.28e-14
34	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(2), PIK3CA(7), PIK3R1(6), POLR1A(3), POLR1B(5), POLR1C(2), POLR1D(2), RB1(3), TP53(73)	3609120	103	85	72	5	43	19	17	2	20	2	<1.00e-15	<1.28e-14
35	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(1), AKT2(2), AKT3(1), CASP9(1), CDC42(1), KDR(3), KRAS(55), MAP2K1(2), MAP2K2(1), MAPK13(1), MAPK3(1), NFATC1(1), NFATC2(3), NFATC3(1), NFATC4(2), NRAS(9), PIK3CA(7), PIK3CB(1), PIK3CD(2), PIK3CG(5), PIK3R1(6), PIK3R3(4), PLA2G4A(4), PLA2G6(2), PLCG1(1), PLCG2(4), PPP3CA(2), PPP3CB(2), PPP3CC(3), PRKCA(3), PRKCG(5), PTGS2(1), PTK2(1), RAF1(4), SH2D2A(1), SHC2(1), SPHK1(1), SRC(3)	12876546	148	85	97	29	36	77	19	0	14	2	<1.00e-15	<1.28e-14
36	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(6), AKT1(1), ATM(15), CDKN1A(1), CPB2(1), CSNK1D(2), FHL2(1), HIF1A(3), IGFBP3(3), MAPK8(6), TP53(73)	3627338	112	85	81	5	42	29	16	3	21	1	<1.00e-15	<1.28e-14
37	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(2), ATM(15), BRCA1(2), CDKN1A(1), CHEK2(1), MAPK8(6), MRE11A(5), NFKB1(4), RAD50(7), TP53(73)	5363590	116	84	85	8	45	32	16	3	19	1	<1.00e-15	<1.28e-14
38	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	AKT1(1), AKT2(2), AKT3(1), BCL10(1), BLNK(1), BTK(2), CARD11(5), CD19(1), CD22(4), CD72(1), CD79A(1), CD79B(1), CHUK(4), CR2(3), FOS(1), GSK3B(2), IKBKB(2), INPP5D(2), KRAS(55), LILRB3(1), MALT1(2), NFATC1(1), NFATC2(3), NFATC3(1), NFATC4(2), NFKB1(4), NFKB2(2), NRAS(9), PIK3CA(7), PIK3CB(1), PIK3CD(2), PIK3CG(5), PIK3R1(6), PIK3R3(4), PLCG2(4), PPP3CA(2), PPP3CB(2), PPP3CC(3), RASGRP3(3), SYK(3), VAV1(7), VAV2(3), VAV3(3)	13520184	170	84	119	25	39	95	21	0	13	2	<1.00e-15	<1.28e-14
39	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	42	APAF1(2), BID(1), BIRC2(2), BIRC3(5), CASP2(1), CASP3(1), CASP6(2), CASP7(1), CASP8(5), CASP9(1), FAS(2), GZMB(2), MAP2K4(2), MAP3K1(2), MAP3K14(1), MAPK10(6), NFKB1(4), TP53(73), TRAF1(1)	6784292	114	83	83	18	44	24	17	2	27	0	<1.00e-15	<1.28e-14
40	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(1), APAF1(2), ATM(15), BID(1), CASP3(1), CASP6(2), CASP7(1), CASP9(1), PRKCA(3), PTK2(1), STAT1(1), TLN1(3), TP53(73)	5072148	105	83	74	8	36	29	14	2	23	1	<1.00e-15	<1.28e-14
41	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(1), AKT2(2), AKT3(1), BTK(2), FCER1A(3), FYN(1), GAB2(1), GRB2(2), IL3(1), IL4(1), INPP5D(2), KRAS(55), LAT(1), LCP2(1), MAP2K1(2), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAPK10(6), MAPK13(1), MAPK3(1), MAPK8(6), MAPK9(2), MS4A2(2), NRAS(9), PDK1(2), PIK3CA(7), PIK3CB(1), PIK3CD(2), PIK3CG(5), PIK3R1(6), PIK3R3(4), PLA2G4A(4), PLA2G6(2), PLCG1(1), PLCG2(4), PRKCA(3), PRKCE(2), RAF1(4), SOS1(3), SOS2(6), SYK(3), VAV1(7), VAV2(3), VAV3(3)	13053926	183	83	132	27	36	97	29	2	17	2	<1.00e-15	<1.28e-14
42	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(15), ATR(7), CDC25C(1), CHEK2(1), TP53(73), YWHAH(1)	2922928	98	83	67	6	39	27	10	2	19	1	<1.00e-15	<1.28e-14
43	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(1), EGFR(5), IGF1R(2), POLR2A(1), PPP2CA(1), PRKCA(3), RB1(3), TEP1(3), TERF1(1), TNKS(1), TP53(73), XRCC5(4)	5126034	98	82	67	7	43	19	14	2	20	0	<1.00e-15	<1.28e-14
44	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(8), DAXX(1), PAX3(3), PML(1), RB1(3), SIRT1(2), SP100(1), TP53(73)	3411914	92	81	61	7	43	14	11	2	22	0	<1.00e-15	<1.28e-14
45	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(10), CPEB1(3), EGFR(5), ERBB2(4), ERBB4(7), ETS1(1), ETS2(1), ETV6(2), FMN2(3), GRB2(2), KRAS(55), MAP2K1(2), MAPK3(1), NOTCH2(6), NOTCH3(5), NOTCH4(6), PIWIL1(3), PIWIL2(5), PIWIL3(3), PIWIL4(3), RAF1(4), SOS1(3), SOS2(6), SPIRE1(1)	8912974	141	79	86	23	22	82	27	2	8	0	<1.00e-15	<1.28e-14
46	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(2), IFNGR1(1), IFNGR2(1), IKBKB(2), JAK2(4), LIN7A(2), NFKB1(4), RB1(3), TP53(73), USH1C(5), WT1(4)	3278802	101	79	70	8	44	22	10	2	22	1	<1.00e-15	<1.28e-14
47	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(2), SP1(1), SP3(2), TP53(73), WT1(4)	1259246	82	77	51	2	40	14	8	2	18	0	<1.00e-15	<1.28e-14
48	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(4), MAP3K14(1), NFKB1(4), TP53(73)	1870534	82	76	51	4	39	13	10	2	18	0	<1.00e-15	<1.28e-14
49	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(2), ATM(15), BUB1(2), BUB1B(3), BUB3(1), CCNA1(3), CCNA2(1), CCNB2(1), CCNB3(6), CCND2(1), CCND3(1), CCNE1(1), CCNE2(1), CCNH(1), CDAN1(3), CDC14A(3), CDC14B(2), CDC20(1), CDC25A(1), CDC25B(2), CDC25C(1), CDC6(1), CDC7(2), CDH1(2), CDK4(1), CDKN1A(1), CHEK2(1), E2F3(2), EP300(8), ESPL1(4), GSK3B(2), HDAC1(2), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(2), MAD1L1(1), MCM3(2), MCM4(1), MCM5(5), MCM6(1), MCM7(2), MPEG1(2), MPL(1), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(1), PLK1(4), PRKDC(5), PTPRA(1), RB1(3), RBL1(4), SMAD4(15), TFDP1(1), TGFB1(1), TP53(73)	20557562	212	99	175	36	73	57	41	6	33	2	1.11e-15	1.37e-14
50	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(1), BRAF(10), C7orf16(2), CACNA1A(9), CRHR1(1), GNA11(1), GNAI1(1), GNAO1(2), GNAQ(1), GNAS(2), GRIA1(6), GRIA2(6), GRIA3(4), GRID2(5), GRM1(5), GRM5(4), GUCY1A2(6), GUCY1A3(5), GUCY1B3(2), GUCY2C(3), GUCY2D(6), GUCY2F(6), IGF1(1), IGF1R(2), ITPR1(8), ITPR2(6), ITPR3(7), KRAS(55), MAP2K1(2), MAP2K2(1), MAPK3(1), NOS1(6), NPR1(2), NPR2(2), NRAS(9), PLA2G4A(4), PLA2G6(2), PLCB1(1), PLCB3(3), PLCB4(2), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(1), PPP2R2B(2), PPP2R2C(2), PRKCA(3), PRKCG(5), PRKG1(8), PRKG2(3), RAF1(4), RYR1(11)	20433892	245	88	186	65	65	113	51	1	14	1	1.11e-15	1.37e-14
51	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDK4(1), CDKN1A(1), CDKN1B(2), PRB1(1), TP53(73)	1455812	78	76	47	3	35	13	7	2	21	0	1.22e-15	1.48e-14
52	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(5), ADCY2(8), ADCY3(2), ADCY4(2), ADCY5(6), ADCY7(2), ADCY8(3), ADCY9(2), ADRB1(1), CSNK1D(2), DRD2(4), EGFR(5), GJA1(4), GJD2(1), GNA11(1), GNAI1(1), GNAQ(1), GNAS(2), GRB2(2), GRM1(5), GRM5(4), GUCY1A2(6), GUCY1A3(5), GUCY1B3(2), GUCY2C(3), GUCY2D(6), GUCY2F(6), HTR2A(1), HTR2B(1), HTR2C(2), ITPR1(8), ITPR2(6), ITPR3(7), KRAS(55), MAP2K1(2), MAP2K2(1), MAP2K5(2), MAP3K2(1), MAPK3(1), NPR1(2), NPR2(2), NRAS(9), PDGFC(1), PDGFRA(4), PDGFRB(2), PLCB1(1), PLCB3(3), PLCB4(2), PRKACA(1), PRKACG(1), PRKCA(3), PRKCG(5), PRKG1(8), PRKG2(3), RAF1(4), SOS1(3), SOS2(6), SRC(3), TJP1(2), TUBA1B(2), TUBA1C(2), TUBA3C(3), TUBA3D(1), TUBA3E(1), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB1(1), TUBB2A(2), TUBB3(1), TUBB4(1), TUBB8(1)	24115612	263	92	212	73	76	130	39	1	15	2	1.33e-15	1.58e-14
53	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(2), ANAPC1(1), ANAPC4(3), ANAPC5(1), ANAPC7(2), ATM(15), ATR(7), BUB1(2), BUB1B(3), BUB3(1), CCNA1(3), CCNA2(1), CCNB2(1), CCNB3(6), CCND2(1), CCND3(1), CCNE1(1), CCNE2(1), CCNH(1), CDC14A(3), CDC14B(2), CDC16(1), CDC20(1), CDC25A(1), CDC25B(2), CDC25C(1), CDC27(8), CDC6(1), CDC7(2), CDK4(1), CDKN1A(1), CDKN1B(2), CHEK2(1), CREBBP(8), CUL1(5), DBF4(4), E2F3(2), EP300(8), ESPL1(4), GSK3B(2), HDAC1(2), MAD1L1(1), MCM3(2), MCM4(1), MCM5(5), MCM6(1), MCM7(2), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(1), PLK1(4), PRKDC(5), RB1(3), RBL1(4), RBL2(3), RBX1(1), SMAD2(6), SMAD3(3), SMAD4(15), SMC1A(4), SMC1B(2), TFDP1(1), TGFB1(1), TGFB2(4), TP53(73), YWHAH(1)	25081470	262	98	222	55	85	76	53	6	40	2	1.44e-15	1.68e-14
54	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(5), ADCY2(8), ADCY3(2), ADCY4(2), ADCY5(6), ADCY7(2), ADCY8(3), ADCY9(2), AKAP10(2), AKAP11(5), AKAP12(4), AKAP3(5), AKAP4(2), AKAP6(8), AKAP7(1), AKAP9(10), ARHGEF1(2), GNA11(1), GNA14(3), GNA15(1), GNAL(2), GNAO1(2), GNAQ(1), GNB3(2), GNG3(1), GNG4(1), GNGT1(1), IL18BP(2), ITPR1(8), KRAS(55), NRAS(9), PDE1A(2), PDE1B(2), PDE1C(5), PDE4A(1), PDE4B(3), PDE4D(1), PDE7B(1), PDE8B(2), PLCB3(3), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCI(1), PRKCQ(2), PRKD1(5), PRKD3(5), RHOA(1), SLC9A1(2), USP5(2)	21564068	220	86	168	63	55	113	27	0	24	1	1.67e-15	1.87e-14
55	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(2), ATM(15), CCNE1(1), CDK4(1), CDKN1A(1), PCNA(1), RB1(3), TIMP3(1), TP53(73)	3356028	98	83	67	8	38	24	11	2	22	1	1.67e-15	1.87e-14
56	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTN1(2), ACTN2(5), ACTN3(1), ACTN4(3), ACVR1B(3), ACVR1C(1), BAIAP2(1), CDC42(1), CDH1(2), CREBBP(8), CSNK2A2(1), CTNNA1(5), CTNNA2(2), CTNNA3(1), CTNNB1(8), CTNND1(1), EGFR(5), EP300(8), ERBB2(4), FARP2(2), FER(2), FGFR1(1), FYN(1), IGF1R(2), INSR(1), IQGAP1(8), LEF1(1), LMO7(6), MAP3K7(2), MAPK3(1), MET(1), MLLT4(3), PARD3(4), PTPN1(4), PTPRF(5), PTPRJ(2), PTPRM(14), PVRL1(4), PVRL2(1), PVRL3(1), PVRL4(1), RHOA(1), SMAD2(6), SMAD3(3), SMAD4(15), SNAI2(1), SORBS1(7), SRC(3), SSX2IP(2), TCF7(5), TCF7L1(1), TCF7L2(8), TGFBR1(5), TGFBR2(2), TJP1(2), VCL(2), WASF1(2), WASF2(1), WASF3(4), WASL(2)	21942326	201	64	194	43	71	72	34	3	19	2	1.15e-12	1.27e-11
57	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	128	CADM3(4), CD22(4), CD226(2), CD274(2), CD28(1), CD40(1), CD40LG(4), CD58(1), CD6(1), CD80(1), CDH1(2), CDH15(1), CDH2(8), CDH3(3), CDH4(5), CDH5(1), CLDN10(3), CLDN16(2), CLDN17(3), CLDN2(1), CLDN8(2), CNTN1(7), CNTN2(4), CNTNAP1(3), CNTNAP2(5), CTLA4(1), ESAM(1), GLG1(1), HLA-A(2), HLA-B(1), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(2), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(3), HLA-DRB1(1), HLA-DRB5(1), HLA-F(1), HLA-G(1), ITGA4(5), ITGA6(2), ITGA8(3), ITGA9(3), ITGAL(4), ITGAM(3), ITGAV(4), ITGB2(2), ITGB7(2), ITGB8(1), L1CAM(2), MAG(2), NCAM1(4), NCAM2(7), NEGR1(3), NEO1(3), NFASC(6), NLGN1(4), NLGN2(2), NLGN3(1), NRCAM(1), NRXN1(4), NRXN2(2), NRXN3(11), PDCD1LG2(1), PECAM1(1), PTPRC(9), PTPRF(5), PTPRM(14), PVRL1(4), PVRL2(1), PVRL3(1), SDC1(1), SDC2(3), SDC3(1), SDC4(1), SELE(2), SELL(3), SELP(2), SELPLG(1), SIGLEC1(2), SPN(1), VCAM1(2), VCAN(18)	26162722	245	65	245	82	74	94	42	4	31	0	1.65e-11	1.79e-10
58	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(3), ACVR1B(3), ACVR1C(1), ACVR2A(2), ACVR2B(2), ACVRL1(2), BMP2(1), BMP4(2), BMP5(3), BMP6(1), BMP7(2), BMPR1A(1), BMPR1B(1), BMPR2(8), CREBBP(8), CUL1(5), DCN(2), EP300(8), FST(2), GDF5(2), GDF6(1), INHBA(3), INHBC(1), INHBE(1), LTBP1(3), MAPK3(1), NODAL(1), PPP2CA(1), PPP2CB(2), PPP2R1A(1), PPP2R1B(1), PPP2R2B(2), PPP2R2C(2), RBL1(4), RBL2(3), RBX1(1), RHOA(1), ROCK1(8), ROCK2(4), RPS6KB2(1), SMAD1(1), SMAD2(6), SMAD3(3), SMAD4(15), SMAD5(1), SMAD9(1), SMURF1(2), SMURF2(2), SP1(1), TFDP1(1), TGFB1(1), TGFB2(4), TGFBR1(5), TGFBR2(2), THBS1(3), THBS2(8), THBS3(2), THBS4(1), ZFYVE16(4), ZFYVE9(4)	17919392	168	58	161	37	54	56	31	1	24	2	2.92e-11	3.10e-10
59	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(1), CAD(4), CDA(1), CTPS(1), DCK(1), DCTD(2), DHODH(1), DPYD(9), DPYS(1), DTYMK(1), ENTPD1(1), ENTPD5(2), ENTPD6(2), NME6(3), NME7(2), NT5C1A(1), NT5C1B(5), NT5C2(2), NT5E(1), PNPT1(6), POLA1(3), POLA2(2), POLD1(2), POLD2(1), POLD3(1), POLE(10), POLE2(1), POLR1A(3), POLR1B(5), POLR1C(2), POLR1D(2), POLR2A(1), POLR2B(3), POLR2D(1), POLR2K(1), POLR3A(6), POLR3B(9), POLR3GL(1), POLR3K(1), PRIM2(3), RFC5(1), RRM1(2), TK2(1), TXNRD1(1), TXNRD2(1), TYMS(2), UCK2(1), UMPS(1), UPB1(2), UPP2(1), UPRT(2)	15048518	120	49	118	26	39	38	23	0	20	0	3.28e-11	3.42e-10
60	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CUL1(5), FBXW7(23), RB1(3), TFDP1(1)	1562708	33	21	27	6	15	4	5	1	8	0	1.18e-10	1.21e-09
61	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(5), ADCY2(8), ADCY3(2), ADCY4(2), ADCY5(6), ADCY7(2), ADCY8(3), ADCY9(2), ADSL(2), ADSS(1), AK2(1), AK5(2), AK7(1), ALLC(2), AMPD1(6), AMPD2(3), AMPD3(1), ATIC(1), DCK(1), ENPP3(2), ENTPD1(1), ENTPD5(2), ENTPD6(2), GART(1), GMPR(1), GUCY1A2(6), GUCY1A3(5), GUCY1B3(2), GUCY2C(3), GUCY2D(6), GUCY2F(6), IMPDH1(2), IMPDH2(3), NME6(3), NME7(2), NPR1(2), NPR2(2), NT5C1A(1), NT5C1B(5), NT5C2(2), NT5E(1), NUDT9(1), PAICS(1), PAPSS1(1), PAPSS2(2), PDE10A(7), PDE11A(2), PDE1A(2), PDE1C(5), PDE3B(1), PDE4A(1), PDE4B(3), PDE4D(1), PDE5A(3), PDE7B(1), PDE8B(2), PDE9A(2), PNPT1(6), POLA1(3), POLA2(2), POLD1(2), POLD2(1), POLD3(1), POLE(10), POLE2(1), POLR1A(3), POLR1B(5), POLR1C(2), POLR1D(2), POLR2A(1), POLR2B(3), POLR2D(1), POLR2K(1), POLR3A(6), POLR3B(9), POLR3GL(1), POLR3K(1), PPAT(5), PRIM2(3), PRPS1(1), PRPS2(1), PRUNE(1), RFC5(1), RRM1(2), XDH(1)	30197542	223	64	221	75	79	69	42	1	32	0	2.23e-09	2.25e-08
62	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(3), ALG1(1), ALG10B(3), ALG11(1), ALG12(1), ALG14(1), ALG2(1), ALG6(1), ALG8(3), ALG9(1), B3GNT2(1), B3GNT7(2), B4GALT1(2), B4GALT3(3), CHPF(1), CHST1(1), CHST11(1), CHST12(1), CHST13(1), CHST4(3), CHSY1(1), DAD1(2), DDOST(1), DPAGT1(1), EXT1(5), EXTL1(1), EXTL2(5), EXTL3(5), FUT11(1), FUT8(2), GALNT11(1), GALNT12(1), GALNT13(1), GALNT14(4), GALNT2(2), GALNT5(5), GALNT6(1), GALNT7(1), GALNT8(1), GALNTL1(2), GALNTL2(3), GALNTL4(1), GALNTL5(3), GANAB(1), GCNT1(2), GCNT3(2), GCNT4(3), HS2ST1(1), HS3ST1(1), HS3ST2(3), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN1C1(3), MAN2A1(7), MGAT1(1), MGAT4A(1), MGAT5(2), NDST1(2), NDST2(1), NDST3(6), NDST4(1), OGT(2), RPN2(1), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1), ST6GALNAC1(2), STT3B(4), WBSCR17(8), XYLT1(2), XYLT2(1)	19757600	149	53	149	47	44	46	39	2	18	0	7.47e-08	7.43e-07
63	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	145	AKT1(1), AKT2(2), AKT3(1), CBL(4), CBLB(3), CCND2(1), CCND3(1), CREBBP(8), CSF2RB(1), CSF3R(5), EP300(8), GH1(1), GH2(2), GHR(1), GRB2(2), IFNA10(3), IFNA2(2), IFNA5(1), IFNAR2(1), IFNGR1(1), IFNGR2(1), IFNK(1), IL10(1), IL10RA(1), IL10RB(3), IL12A(1), IL12B(1), IL12RB2(2), IL13RA1(2), IL13RA2(2), IL15(1), IL19(1), IL2(2), IL20(1), IL20RA(3), IL21R(4), IL22RA1(1), IL23R(1), IL28RA(1), IL2RB(1), IL3(1), IL4(1), IL5RA(2), IL6(2), IL6R(1), IL6ST(1), IL7(1), IL7R(2), IL9(2), IRF9(1), JAK1(1), JAK2(4), JAK3(4), LEPR(5), LIFR(13), MPL(1), OSMR(2), PIAS1(1), PIAS2(2), PIAS3(2), PIK3CA(7), PIK3CB(1), PIK3CD(2), PIK3CG(5), PIK3R1(6), PIK3R3(4), PRL(1), PRLR(2), PTPN11(4), SOCS2(1), SOCS4(1), SOCS5(2), SOS1(3), SOS2(6), SPRED1(2), SPRED2(2), SPRY1(3), SPRY4(1), STAM(1), STAM2(1), STAT1(1), STAT2(4), STAT3(1), STAT4(3), STAT5B(1), STAT6(1), TPO(4)	25823332	199	59	198	57	49	82	43	2	20	3	1.95e-07	1.90e-06
64	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(5), ARHGEF1(2), F2(2), GNAI1(1), GNAQ(1), GNGT1(1), MAP3K7(2), PIK3CA(7), PIK3R1(6), PLCB1(1), PPP1R12B(4), PRKCA(3), PTK2B(1), ROCK1(8)	4697232	44	27	44	13	10	13	10	1	8	2	2.80e-07	2.70e-06
65	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	FOS(1), FYN(1), GRB2(2), LAT(1), LCK(2), MAP2K1(2), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(6), NFATC1(1), NFATC2(3), NFATC3(1), NFATC4(2), NFKB1(4), PIK3CA(7), PIK3R1(6), PLCG1(1), PPP3CA(2), PPP3CB(2), PPP3CC(3), PRKCA(3), PTPN7(2), RAF1(4), RASA1(5), SHC1(1), SOS1(3), VAV1(7), ZAP70(1)	8604958	78	37	78	12	27	23	15	1	10	2	4.33e-07	4.11e-06
66	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(1), PIK3CA(7), PIK3R1(6), PLCB1(1), PLCG1(1), PRKCA(3), VAV1(7)	2374212	26	21	26	6	5	9	7	1	2	2	9.44e-07	8.81e-06
67	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD80(1), CTLA4(1), GRB2(2), HLA-DRA(3), HLA-DRB1(1), IL2(2), ITK(4), LCK(2), PIK3CA(7), PIK3R1(6), PTPN11(4)	2273696	34	20	34	6	9	15	6	0	2	2	1.02e-06	9.42e-06
68	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(2), FCER1A(3), FOS(1), GRB2(2), MAP2K1(2), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(6), NFATC1(1), NFATC2(3), NFATC3(1), NFATC4(2), PAK2(3), PIK3CA(7), PIK3R1(6), PLA2G4A(4), PLCG1(1), PPP3CA(2), PPP3CB(2), PPP3CC(3), RAF1(4), SHC1(1), SOS1(3), SYK(3), VAV1(7)	7652036	74	35	74	12	21	21	15	1	14	2	1.54e-06	0.000014
69	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(4), HLA-A(2), KLRC3(1), LAT(1), MAP2K1(2), MAPK3(1), PAK1(1), PIK3CA(7), PIK3R1(6), PTK2B(1), SYK(3), VAV1(7)	3426036	36	21	36	4	7	10	10	0	6	3	1.60e-06	0.000014
70	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(3), ACVR1B(3), ACVRL1(2), AKT1(1), BMPR1A(1), BMPR2(8), BUB1(2), CDKL1(2), CDKL2(2), CDS1(2), CDS2(2), CLK1(2), CLK4(2), CSNK2A2(1), DGKA(1), DGKB(2), DGKD(8), DGKE(2), DGKG(2), DGKH(7), DGKZ(1), IMPA1(1), INPP4A(1), INPP4B(2), INPPL1(3), MAP3K10(1), MOS(1), NEK1(2), OCRL(6), PIK3C2A(3), PIK3C2B(6), PIK3C2G(2), PIK3CA(7), PIK3CB(1), PIK3CG(5), PLCB1(1), PLCB3(3), PLCB4(2), PLCD1(4), PLCG1(1), PLCG2(4), PRKACA(1), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCQ(2), PRKD1(5), PRKG1(8), RAF1(4), RPS6KA2(4), RPS6KA3(2), TGFBR1(5), VRK1(2)	20808728	163	58	162	48	50	58	35	2	18	0	2.71e-06	0.000024
71	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	246	ACVR1(3), ACVR1B(3), ACVR2A(2), ACVR2B(2), BMP2(1), BMP7(2), BMPR1A(1), BMPR1B(1), BMPR2(8), CCL18(1), CCL22(1), CCL27(2), CCL8(1), CCR1(1), CCR3(2), CCR4(1), CCR5(1), CCR7(2), CCR8(2), CCR9(3), CD40(1), CD40LG(4), CD70(1), CSF1(1), CSF2RB(1), CSF3R(5), CX3CL1(1), CX3CR1(1), CXCL10(1), CXCL11(2), CXCL14(2), CXCL16(1), CXCL5(1), CXCL9(2), CXCR4(1), EDA(1), EDA2R(1), EDAR(2), EGFR(5), FAS(2), FLT1(4), FLT3(2), FLT4(1), GDF5(2), GH1(1), GH2(2), GHR(1), HGF(3), IFNA10(3), IFNA2(2), IFNA5(1), IFNAR2(1), IFNGR1(1), IFNGR2(1), IFNK(1), IL10(1), IL10RA(1), IL10RB(3), IL12A(1), IL12B(1), IL12RB2(2), IL13RA1(2), IL15(1), IL17A(2), IL17RA(2), IL18R1(4), IL18RAP(2), IL19(1), IL1B(1), IL1R1(1), IL1R2(5), IL1RAP(1), IL2(2), IL20(1), IL20RA(3), IL21R(4), IL22RA1(1), IL23R(1), IL28RA(1), IL2RB(1), IL3(1), IL4(1), IL5RA(2), IL6(2), IL6R(1), IL6ST(1), IL7(1), IL7R(2), IL8(1), IL9(2), INHBA(3), INHBC(1), INHBE(1), KDR(3), KIT(2), KITLG(1), LEPR(5), LIFR(13), LTBR(1), MET(1), MPL(1), NGFR(1), OSMR(2), PDGFC(1), PDGFRA(4), PDGFRB(2), PRL(1), PRLR(2), RELT(1), TGFB1(1), TGFB2(4), TGFBR1(5), TGFBR2(2), TNFRSF10B(4), TNFRSF10D(1), TNFRSF11A(1), TNFRSF17(2), TNFRSF21(2), TNFRSF8(1), TNFRSF9(2), TNFSF13B(1), TPO(4), VEGFC(3), XCL2(1), XCR1(1)	31469572	242	56	240	92	60	96	49	1	35	1	6.97e-06	0.000060
72	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(2), ACTN2(5), ACTN3(1), ACTN4(3), ARHGAP5(4), CDC42(1), CDH5(1), CLDN10(3), CLDN16(2), CLDN17(3), CLDN2(1), CLDN8(2), CTNNA1(5), CTNNA2(2), CTNNA3(1), CTNNB1(8), CTNND1(1), CXCR4(1), CYBB(1), ESAM(1), GNAI1(1), GRLF1(5), ITGA4(5), ITGAL(4), ITGAM(3), ITGB2(2), ITK(4), MAPK13(1), MLLT4(3), MMP2(3), MMP9(6), MSN(3), MYL9(2), NCF2(1), NCF4(1), NOX3(4), PECAM1(1), PIK3CA(7), PIK3CB(1), PIK3CD(2), PIK3CG(5), PIK3R1(6), PIK3R3(4), PLCG1(1), PLCG2(4), PRKCA(3), PRKCG(5), PTK2(1), PTK2B(1), PTPN11(4), RAP1A(1), RAP1B(1), RAPGEF3(3), RASSF5(1), RHOA(1), RHOH(1), ROCK1(8), ROCK2(4), TXK(2), VAV1(7), VAV2(3), VAV3(3), VCAM1(2), VCL(2)	22695944	180	60	180	50	69	66	29	0	14	2	7.65e-06	0.000065
73	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA1(4), ADORA2A(2), ADORA2B(1), ADRA1A(1), ADRA1B(2), ADRA2A(1), ADRB1(1), AGTR1(3), AGTR2(1), AVPR1A(1), BDKRB2(1), BRS3(2), C3AR1(3), CCBP2(6), CCKAR(1), CCKBR(4), CCR1(1), CCR3(2), CCR4(1), CCR5(1), CCR7(2), CCR8(2), CCR9(3), CCRL1(3), CHML(2), CHRM1(1), CHRM2(3), CHRM4(1), CHRM5(2), CNR1(3), CX3CR1(1), CXCR4(1), DRD2(4), DRD3(2), DRD5(4), EDNRA(1), EDNRB(5), F2RL1(1), F2RL2(1), FSHR(2), GALR1(1), GALT(1), GHSR(2), GPR17(1), GPR174(2), GPR37(3), GPR6(2), GPR63(2), GPR77(1), GPR87(2), GRPR(1), HRH2(1), HTR1A(2), HTR1B(2), HTR1D(1), HTR1E(4), HTR2A(1), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(4), HTR7(1), LTB4R(1), MAS1(1), MC4R(2), MC5R(2), MLNR(1), NMUR1(1), NMUR2(5), NPY1R(2), NPY2R(1), NPY5R(1), NTSR2(2), OPN1SW(2), OPRK1(1), OPRM1(2), OR12D3(3), OR1C1(2), OR2H1(1), OR5V1(1), OR7A5(2), OR7C1(2), OR8B8(3), OXTR(1), P2RY1(4), P2RY10(4), P2RY12(2), P2RY14(3), P2RY2(1), P2RY6(1), PPYR1(3), PTGDR(1), PTGFR(3), RGR(1), RHO(2), RRH(2), SSTR1(2), SSTR2(1), SSTR4(2), SUCNR1(2), TRHR(3)	21067086	197	61	197	66	70	71	39	2	15	0	8.23e-06	0.000069
74	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(1), ASAH1(1), ATF1(1), BRAF(10), CREB3(2), CREB5(2), CREBBP(8), DAG1(3), EGR1(1), EGR2(3), FRS2(2), GNAQ(1), MAP1B(16), MAP2K4(2), MAPK10(6), MAPK3(1), MAPK8(6), MAPK8IP3(1), MAPK9(2), NTRK1(3), OPN1LW(1), PIK3C2G(2), PIK3CA(7), PIK3CD(2), PIK3R1(6), PTPN11(4), RPS6KA3(2), SHC1(1), SRC(3), TERF2IP(2)	9235650	102	40	95	25	26	33	25	2	14	2	8.71e-06	0.000072
75	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(1), GRB2(2), KLK2(3), NTRK1(3), PIK3CA(7), PIK3R1(6), PLCG1(1), PRKCA(3), SHC1(1), SOS1(3)	2851922	30	23	28	5	4	13	9	0	2	2	8.77e-06	0.000072
76	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(1), ANAPC4(3), ANAPC5(1), ANAPC7(2), BTRC(3), CDC16(1), CDC20(1), CDC27(8), CUL1(5), CUL2(3), FBXW11(4), FBXW7(23), ITCH(1), RBX1(1), SMURF1(2), SMURF2(2), UBA1(2), UBE2C(1), UBE2D3(1), UBE2E2(1), VHL(1), WWP1(3)	7396724	70	31	61	26	25	16	16	1	12	0	0.000012	0.000099
77	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	100	AKT1(1), AKT2(2), AKT3(1), CASP8(5), CD40(1), CD80(1), CHUK(4), CXCL10(1), CXCL11(2), CXCL9(2), FOS(1), IFNA10(3), IFNA2(2), IFNA5(1), IFNAR2(1), IKBKB(2), IKBKE(1), IL12A(1), IL12B(1), IL1B(1), IL6(2), IL8(1), IRAK4(2), IRF3(2), MAP2K1(2), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K7(2), MAP3K8(1), MAPK10(6), MAPK13(1), MAPK3(1), MAPK8(6), MAPK9(2), MYD88(1), NFKB1(4), NFKB2(2), PIK3CA(7), PIK3CB(1), PIK3CD(2), PIK3CG(5), PIK3R1(6), PIK3R3(4), STAT1(1), TBK1(2), TICAM1(1), TLR1(3), TLR2(4), TLR3(2), TLR4(4), TLR5(2), TLR6(1), TLR7(5), TLR8(3), TLR9(4), TOLLIP(1), TRAF3(2), TRAF6(1)	16199984	138	47	138	32	38	48	32	2	15	3	0.000029	0.00023
78	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(5), CREM(2), FHL5(3), FSHB(2), FSHR(2), GNAS(2), XPO1(1)	1676768	17	16	17	7	7	2	4	1	3	0	0.000031	0.00024
79	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(3), ERBB4(7), NRG2(3), NRG3(5), PRKCA(3)	1646150	21	16	21	4	5	8	2	1	5	0	0.000034	0.00026
80	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(5), AKT1(1), ASAH1(1), GNAI1(1), GNGT1(1), ITGAV(4), ITGB3(2), MAPK3(1), PDGFRA(4), PIK3CA(7), PIK3R1(6), PLCB1(1), PRKCA(3), PTK2(1), SPHK1(1), SRC(3)	4979766	42	26	42	16	10	15	8	1	6	2	0.000045	0.00035
81	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(8), EP300(8), FYN(1), IL7(1), IL7R(2), JAK1(1), JAK3(4), LCK(2), NMI(1), PIK3CA(7), PIK3R1(6), PTK2B(1), STAT5B(1)	5142756	43	26	43	9	9	19	7	1	5	2	0.000059	0.00045
82	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(1), MAP2K1(2), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP3K1(2), MAPK3(1), NFKB1(4), PIK3CA(7), PIK3R1(6), RB1(3), SP1(1)	3608338	33	21	33	6	10	8	9	1	3	2	0.000065	0.00049
83	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(1), CAT(1), GH1(1), GHR(1), IGF1(1), IGF1R(2), PIK3CA(7), PIK3R1(6), SHC1(1)	2380920	21	18	21	9	7	4	6	0	2	2	0.000098	0.00073
84	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	FOS(1), GRB2(2), JAK2(4), MAP2K1(2), MAPK3(1), MPL(1), PIK3CA(7), PIK3R1(6), PLCG1(1), PRKCA(3), RAF1(4), RASA1(5), SHC1(1), SOS1(3), STAT1(1), STAT3(1), STAT5B(1), THPO(1)	5487612	45	26	45	7	11	15	11	0	5	3	0.00010	0.00074
85	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(4), CALR(1), CANX(1), CIITA(1), CTSB(3), CTSL1(2), HLA-A(2), HLA-B(1), HLA-DMB(1), HLA-DOA(1), HLA-DPB1(2), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(3), HLA-DRB1(1), HLA-DRB5(1), HLA-F(1), HLA-G(1), HSP90AA1(1), HSP90AB1(2), HSPA5(1), IFNA10(3), IFNA2(2), IFNA5(1), KIR2DL1(2), KIR2DL4(1), KIR3DL1(1), KIR3DL2(1), KIR3DL3(3), KLRC3(1), LGMN(3), NFYA(3), NFYC(1), PDIA3(1), RFX5(1), RFXAP(1), TAP1(3), TAP2(2), TAPBP(3)	7700344	66	27	66	18	11	26	12	1	14	2	0.00010	0.00074
86	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	DUSP1(2), GORASP1(3), MAP2K4(2), MAPK10(6), MAPK13(1), MAPK3(1), MAPK8(6), MAPK8IP3(1), MAPK9(2), NFKB1(4), NFKB2(2), PIK3CA(7), PIK3CD(2), PIK3R1(6), TRAF3(2), TRAF5(3), TRAF6(1)	5765684	51	30	51	12	15	10	13	1	10	2	0.00012	0.00084
87	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	FOS(1), GRB2(2), JAK1(1), MAP2K1(2), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(6), PDGFRA(4), PIK3CA(7), PIK3R1(6), PLCG1(1), PRKCA(3), RAF1(4), RASA1(5), SHC1(1), SOS1(3), STAT1(1), STAT3(1)	6365722	53	27	53	9	14	18	13	1	5	2	0.00012	0.00084
88	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(15), CDC25A(1), CDC25B(2), CDC25C(1), MYT1(9), YWHAH(1)	2551134	29	17	29	3	7	14	4	1	2	1	0.00015	0.0011
89	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	FOS(1), GRB2(2), IGF1(1), IGF1R(2), IRS1(4), MAP2K1(2), MAPK3(1), MAPK8(6), PIK3CA(7), PIK3R1(6), PTPN11(4), RAF1(4), RASA1(5), SHC1(1), SOS1(3)	4435784	49	25	49	6	14	16	11	1	5	2	0.00016	0.0011
90	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	FOS(1), GRB2(2), INSR(1), IRS1(4), MAP2K1(2), MAPK3(1), MAPK8(6), PIK3CA(7), PIK3R1(6), PTPN11(4), RAF1(4), RASA1(5), SHC1(1), SLC2A4(2), SOS1(3)	4572536	49	24	49	5	12	16	12	1	6	2	0.00016	0.0011
91	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(1), CASP9(1), CHUK(4), GH1(1), GHR(1), NFKB1(4), PDPK1(1), PIK3CA(7), PIK3R1(6), PPP2CA(1), YWHAH(1)	2583942	28	18	28	5	10	5	10	0	1	2	0.00017	0.0011
92	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGFR(5), FOS(1), GRB2(2), JAK1(1), MAP2K1(2), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(6), PIK3CA(7), PIK3R1(6), PLCG1(1), PRKCA(3), RAF1(4), RASA1(5), SHC1(1), SOS1(3), STAT1(1), STAT3(1)	6836584	54	29	54	8	16	17	13	1	5	2	0.00018	0.0012
93	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(1), CHRNG(2), MUSK(2), PIK3CA(7), PIK3R1(6), PTK2(1), PTK2B(1), SRC(3), YWHAH(1)	3041204	24	19	24	6	6	7	5	0	4	2	0.00018	0.0012
94	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(3), BDKRB2(1), C1QB(1), C1QC(1), C1R(1), C1S(4), C2(4), C3(2), C3AR1(3), C4BPA(6), C5(5), C5AR1(2), C6(6), C7(3), C8A(4), C8B(3), C9(2), CD46(1), CD55(2), CFB(2), CFH(6), CPB2(1), CR1(3), CR2(3), F11(1), F13A1(5), F13B(2), F2(2), F3(1), F5(10), F7(1), F8(5), FGA(6), FGB(1), FGG(2), KLKB1(5), KNG1(1), MASP1(5), MASP2(2), PLAT(3), PLAU(1), PLAUR(2), PLG(4), PROS1(3), SERPINA1(3), SERPINA5(2), SERPINC1(1), SERPIND1(1), SERPINE1(3), SERPING1(2), TFPI(3), VWF(7)	16342862	153	48	153	41	42	63	29	0	19	0	0.00018	0.0012
95	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(1), CDKN1B(2), GRB2(2), MAPK3(1), PDK2(1), PDPK1(1), PIK3CA(7), PIK3R1(6), PTEN(4), PTK2(1), SHC1(1), SOS1(3)	3458652	30	19	30	5	4	8	9	0	7	2	0.00022	0.0014
96	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	CXCR4(1), GNAI1(1), GNAQ(1), GNGT1(1), MAP2K1(2), MAPK3(1), NFKB1(4), PIK3C2G(2), PIK3CA(7), PIK3R1(6), PLCG1(1), PRKCA(3), PTK2(1), PTK2B(1), RAF1(4)	5092292	36	23	36	9	12	10	7	0	5	2	0.00029	0.0019
97	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(1), AKT2(2), AKT3(1), BRAF(10), EIF4B(1), FIGF(2), HIF1A(3), IGF1(1), MAPK3(1), PDPK1(1), PGF(1), PIK3CA(7), PIK3CB(1), PIK3CD(2), PIK3CG(5), PIK3R1(6), PIK3R3(4), PRKAA1(1), PRKAA2(4), RICTOR(5), RPS6KA2(4), RPS6KA3(2), RPS6KA6(3), RPS6KB2(1), TSC1(2), TSC2(1), ULK1(1), VEGFC(3)	9419748	76	31	69	18	22	21	21	0	10	2	0.00034	0.0022
98	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BRAF(10), CREB3(2), CREB5(2), RAF1(4), SNX13(3), SRC(3), TERF2IP(2)	2139330	27	17	20	4	7	6	12	1	1	0	0.00039	0.0024
99	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(1), CASP9(1), CDC42(1), CHUK(4), MAP2K1(2), MAPK3(1), NFKB1(4), PIK3CA(7), PIK3R1(6), RAF1(4), RALA(1), RALBP1(2), RALGDS(1), RHOA(1)	3499844	36	21	36	5	14	5	12	0	3	2	0.00040	0.0025
100	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTA2(1), ACTN2(5), ACTN3(1), ACTN4(3), DMD(23), FAM48A(3), MYBPC1(2), MYBPC3(1), MYH3(7), MYH6(5), MYH7(5), MYH8(7), MYL4(1), MYL9(2), MYOM1(4), NEB(16), TMOD1(1), TNNT2(2), TPM2(3), TPM3(1), TPM4(1), TTN(105), VIM(3)	25760968	203	51	202	48	66	75	42	1	17	2	0.00044	0.0027
101	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), DOCK1(2), FOS(1), GAB1(1), GRB2(2), HGF(3), ITGA1(1), MAP2K1(2), MAP2K2(1), MAP4K1(1), MAPK3(1), MAPK8(6), MET(1), PAK1(1), PIK3CA(7), PIK3R1(6), PTEN(4), PTK2(1), PTK2B(1), PTPN11(4), RAF1(4), RAP1A(1), RAP1B(1), RASA1(5), SOS1(3), SRC(3), STAT3(1)	8316696	65	29	65	16	19	20	16	1	7	2	0.00047	0.0029
102	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(1), GRB2(2), IGF1R(2), IRS1(4), MAP2K1(2), MAPK3(1), PIK3CA(7), PIK3R1(6), RAF1(4), SHC1(1), SOS1(3), YWHAH(1)	3380276	34	21	34	5	9	10	9	0	4	2	0.00055	0.0034
103	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGFR(5), ERBB3(6), NRG1(9)	1871604	20	15	18	4	7	3	7	1	2	0	0.00058	0.0035
104	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ARHGEF2(2), ARPC5L(2), CDC42(1), CDH1(2), CTNNB1(8), CTTN(1), FYN(1), HCLS1(6), NCK1(1), NCL(1), PRKCA(3), RHOA(1), ROCK1(8), ROCK2(4), TLR4(4), TLR5(2), TUBA1B(2), TUBA1C(2), TUBA3C(3), TUBA3D(1), TUBA3E(1), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB1(1), TUBB2A(2), TUBB3(1), TUBB4(1), TUBB8(1), WASL(2)	9254386	71	31	71	18	23	25	14	0	9	0	0.00064	0.0038
105	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ARHGEF2(2), ARPC5L(2), CDC42(1), CDH1(2), CTNNB1(8), CTTN(1), FYN(1), HCLS1(6), NCK1(1), NCL(1), PRKCA(3), RHOA(1), ROCK1(8), ROCK2(4), TLR4(4), TLR5(2), TUBA1B(2), TUBA1C(2), TUBA3C(3), TUBA3D(1), TUBA3E(1), TUBA4A(2), TUBA8(2), TUBAL3(1), TUBB1(1), TUBB2A(2), TUBB3(1), TUBB4(1), TUBB8(1), WASL(2)	9254386	71	31	71	18	23	25	14	0	9	0	0.00064	0.0038
106	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(4), CD28(1), CSK(2), CTLA4(1), DAG1(3), DTYMK(1), EPHB2(3), FBXW7(23), GRAP2(4), GRB2(2), ITK(4), LAT(1), LCK(2), LCP2(1), NCK1(1), NFKB1(4), NFKB2(2), PAK1(1), PAK2(3), PAK3(3), PAK7(3), PLCG1(1), PTPRC(9), RAF1(4), RASGRP1(3), RASGRP2(2), RASGRP3(3), RASGRP4(1), SOS1(3), SOS2(6), VAV1(7), ZAP70(1)	10083654	109	36	102	22	42	37	16	1	13	0	0.00076	0.0044
107	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(5), F2(2), FGA(6), FGB(1), FGG(2), PLAT(3), PLAU(1), PLG(4), SERPINB2(1), SERPINE1(3)	2470992	29	18	29	2	11	9	5	0	4	0	0.00079	0.0045
108	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	FOS(1), GRB2(2), KLK2(3), MAP2K1(2), MAPK3(1), MAPK8(6), NGFR(1), PIK3CA(7), PIK3R1(6), PLCG1(1), RAF1(4), SHC1(1), SOS1(3)	3434930	38	21	36	6	9	13	10	1	3	2	0.00081	0.0046
109	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(1), AKT2(2), AKT3(1), GRB2(2), MAPK3(1), PDK1(2), PIK3CA(7), PIK3CD(2), PTEN(4), PTK2B(1), RBL2(3), SHC1(1), SOS1(3)	3703292	30	19	30	8	6	10	9	0	5	0	0.00088	0.0050
110	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(5), AKT1(1), CAMK2D(2), GNAS(2), GRB2(2), MAPK3(1), PIK3CA(7), PIK3R1(6), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), PRKCA(3), RPS6KA5(4), SOS1(3)	5263416	43	26	43	10	13	13	12	0	3	2	0.00090	0.0051
111	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	CPT1B(1), CREBBP(8), DUSP1(2), EP300(8), FABP1(1), HSD17B4(1), LPL(2), MAPK3(1), ME1(3), NCOA1(3), NCOR1(7), NR1H3(2), NR2F1(2), NRIP1(2), PIK3CA(7), PIK3R1(6), PPARA(1), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), PRKCA(3), PTGS2(1), RB1(3), SP1(1), STAT5B(1)	11276570	73	35	73	23	24	20	16	1	10	2	0.00098	0.0054
112	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(4), FYN(1), LRP8(4), RELN(13), VLDLR(4)	2538344	26	14	25	9	8	10	4	1	3	0	0.0013	0.0069
113	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(15), BMPR1B(1), CCND2(1), CDK4(1), CDKN1B(2), DAZL(1), DMC1(2), EGR1(1), FSHR(2), GJA4(1), INHA(1), MLH1(3), MSH5(2), NCOR1(7), NRIP1(2), PRLR(2), VDR(1), ZP2(1)	6214344	46	23	46	13	11	15	10	1	8	1	0.0013	0.0071
114	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(2), C5(5), C6(6), C7(3), C8A(4), C9(2)	2359956	22	14	22	4	6	9	3	0	4	0	0.0018	0.0096
115	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CDKN1B(2), CUL1(5), NEDD8(1), RB1(3), RBX1(1), TFDP1(1)	1587438	14	12	14	6	6	0	3	0	5	0	0.0020	0.011
116	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CDS1(2), CDS2(2), DGKA(1), DGKB(2), DGKD(8), DGKE(2), DGKG(2), DGKH(7), DGKI(7), DGKZ(1), IMPA1(1), IMPA2(1), INPP4A(1), INPP4B(2), INPP5D(2), INPPL1(3), ITGB1BP3(1), ITPR1(8), ITPR2(6), ITPR3(7), OCRL(6), PI4KA(9), PI4KB(1), PIK3C2A(3), PIK3C2B(6), PIK3C2G(2), PIK3C3(5), PIK3CA(7), PIK3CB(1), PIK3CD(2), PIK3CG(5), PIK3R1(6), PIK3R3(4), PIP4K2C(1), PIP5K1B(1), PIP5K1C(3), PLCB1(1), PLCB3(3), PLCB4(2), PLCD1(4), PLCE1(2), PLCG1(1), PLCG2(4), PLCZ1(1), PRKCA(3), PRKCG(5), PTEN(4), SYNJ1(4), SYNJ2(1)	23066968	163	53	163	41	62	53	26	1	18	3	0.0021	0.011
117	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM17(3), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(4), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), CASP3(1), CDC42(1), CHUK(4), CSK(2), EGFR(5), GIT1(1), IGSF5(6), IKBKB(2), IL8(1), MAP2K4(2), MAP3K14(1), MAPK10(6), MAPK13(1), MAPK8(6), MAPK9(2), MET(1), NFKB1(4), NFKB2(2), NOD1(2), PAK1(1), PLCG1(1), PLCG2(4), PTPN11(4), PTPRZ1(8), SRC(3), TJP1(2)	12931576	96	40	96	26	30	32	21	1	11	1	0.0021	0.011
118	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(1), AGT(2), AKT1(1), CALR(1), CAMK1(2), CAMK1G(3), CAMK4(1), CREBBP(8), ELSPBP1(1), F2(2), GSK3B(2), HAND1(1), HAND2(2), IGF1(1), MAP2K1(2), MAPK3(1), MAPK8(6), MEF2C(2), MYH2(5), NFATC1(1), NFATC2(3), NFATC3(1), NFATC4(2), PIK3CA(7), PIK3R1(6), PPP3CA(2), PPP3CB(2), PPP3CC(3), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), RAF1(4)	9090078	82	34	82	18	31	23	14	1	11	2	0.0021	0.011
119	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(1), ACTR3(1), ARPC1B(1), ARPC2(1), CDC42(1), PAK1(1), PDGFRA(4), PIK3CA(7), PIK3R1(6), WASL(2)	2466190	25	13	25	6	7	5	8	0	3	2	0.0028	0.014
120	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CHN1(1), LIMK1(2), MAP3K1(2), MYLK(5), NCF2(1), PAK1(1), PDGFRA(4), PIK3CA(7), PIK3R1(6), PLD1(6), PPP1R12B(4), RALBP1(2), TRIO(3), VAV1(7), WASF1(2)	6408512	53	29	53	11	14	20	12	0	5	2	0.0029	0.015
121	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(5), EXTL1(1), EXTL2(5), EXTL3(5), GLCE(4), HS2ST1(1), HS3ST1(1), HS3ST2(3), HS6ST3(1), NDST1(2), NDST2(1), NDST3(6), NDST4(1)	3771612	36	25	36	11	12	12	8	1	3	0	0.0029	0.015
122	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN2(5), ACTN3(1), CSK(2), CTNNA1(5), CTNNA2(2), CTNNB1(8), PECAM1(1), PTK2(1), SRC(3), VCL(2)	3590446	32	24	32	8	15	12	4	0	1	0	0.0030	0.015
123	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(1), CCNE1(1), CDK4(1), CDKN1A(1), CDKN1B(2), MAPK3(1), NFKB1(4), PAK1(1), PIK3CA(7), PIK3R1(6), RAF1(4), RB1(3), TFDP1(1)	3719568	33	19	33	7	13	5	8	0	5	2	0.0031	0.016
124	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	234	ADCYAP1R1(1), ADORA1(4), ADORA2A(2), ADORA2B(1), ADRA1A(1), ADRA1B(2), ADRA2A(1), ADRA2B(1), ADRB1(1), AGTR1(3), AGTR2(1), AVPR1A(1), BDKRB2(1), BRS3(2), C3AR1(3), C5AR1(2), CALCR(4), CALCRL(4), CCKAR(1), CCKBR(4), CGA(1), CHRM1(1), CHRM2(3), CHRM4(1), CHRM5(2), CNR1(3), CRHR1(1), CRHR2(2), CTSG(2), CYSLTR1(2), CYSLTR2(3), DRD2(4), DRD3(2), DRD5(4), EDNRA(1), EDNRB(5), F2(2), F2RL1(1), F2RL2(1), FSHB(2), FSHR(2), GABBR1(4), GABBR2(4), GABRA1(2), GABRA2(3), GABRA3(3), GABRA4(2), GABRA5(1), GABRA6(1), GABRB1(2), GABRB2(3), GABRB3(5), GABRG1(2), GABRG2(4), GABRP(2), GABRQ(2), GABRR2(1), GALR1(1), GH1(1), GH2(2), GHR(1), GHRHR(1), GHSR(2), GLP1R(5), GLP2R(4), GLRA1(1), GLRA2(1), GLRA3(3), GLRB(2), GPR156(3), GPR63(2), GRIA1(6), GRIA2(6), GRIA3(4), GRIA4(9), GRID1(7), GRID2(5), GRIK1(1), GRIK2(4), GRIK3(7), GRIK4(2), GRIK5(1), GRIN1(1), GRIN2A(9), GRIN2B(3), GRIN2C(2), GRIN2D(2), GRIN3A(4), GRM1(5), GRM2(3), GRM3(3), GRM4(2), GRM5(4), GRM6(2), GRM7(5), GRM8(2), GRPR(1), GZMA(2), HRH2(1), HRH4(1), HTR1A(2), HTR1B(2), HTR1D(1), HTR1E(4), HTR2A(1), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(4), HTR7(1), LEPR(5), LTB4R(1), MAS1(1), MC2R(3), MC4R(2), MC5R(2), MCHR2(2), MLNR(1), NMUR1(1), NMUR2(5), NPFFR2(2), NPY1R(2), NPY2R(1), NPY5R(1), NR3C1(1), NTSR2(2), OPRK1(1), OPRM1(2), OXTR(1), P2RX1(1), P2RX2(1), P2RX3(1), P2RX4(1), P2RX7(1), P2RY1(4), P2RY10(4), P2RY14(3), P2RY2(1), P2RY6(1), PARD3(4), PPYR1(3), PRL(1), PRLR(2), PRSS3(2), PTGDR(1), PTGER3(1), PTGFR(3), PTH2R(4), RXFP1(1), RXFP2(4), SSTR1(2), SSTR2(1), SSTR4(2), TAAR1(1), TAAR5(2), TAAR6(3), TAAR8(1), TAAR9(2), TACR1(1), TACR3(3), THRB(1), TRHR(3), TRPV1(1), TSHB(1), TSHR(4), VIPR1(3), VIPR2(1)	39395746	390	80	389	151	141	135	77	3	33	1	0.0035	0.017
125	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT1(1), AGPAT4(4), AGPAT6(1), CDS1(2), CDS2(2), CHAT(1), CHKA(2), CHPT1(1), DGKA(1), DGKB(2), DGKD(8), DGKE(2), DGKG(2), DGKH(7), DGKI(7), DGKZ(1), ESCO1(6), ESCO2(1), ETNK1(1), ETNK2(2), GNPAT(1), GPAM(1), GPD1L(1), GPD2(1), LCAT(1), MYST3(10), MYST4(7), PCYT1A(2), PCYT1B(1), PEMT(1), PISD(2), PLA2G4A(4), PLA2G6(2), PLD1(6), PLD2(1), PTDSS1(4), SH3GLB1(1)	11931604	102	39	102	30	39	27	24	1	11	0	0.0035	0.017
126	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(3), AGTR2(1), ATP8A1(7), AVPR1A(1), BDKRB2(1), BRS3(2), C3AR1(3), CCKAR(1), CCKBR(4), CCR1(1), CCR3(2), CCR4(1), CCR5(1), CCR7(2), CCR8(2), CX3CR1(1), CXCR4(1), EDNRA(1), EDNRB(5), FSHR(2), GALR1(1), GALT(1), GHSR(2), GPR77(1), GRPR(1), MC2R(3), MC4R(2), MC5R(2), NPY1R(2), NPY2R(1), NPY5R(1), NTSR2(2), OPRK1(1), OPRM1(2), OXTR(1), PPYR1(3), SSTR1(2), SSTR2(1), SSTR4(2), TACR1(1), TACR3(3), TRHR(3), TSHR(4)	9151936	84	36	84	32	27	27	23	1	6	0	0.0035	0.017
127	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(1), ACTR3(1), AKT1(1), AKT2(2), AKT3(1), ANGPTL2(4), ARHGEF11(6), BTK(2), CDC42(1), INPPL1(3), ITPR1(8), ITPR2(6), ITPR3(7), LIMK1(2), MYLK(5), MYLK2(2), PAK1(1), PAK2(3), PAK3(3), PAK7(3), PDK1(2), PIK3CA(7), PIK3CD(2), PIK3CG(5), PIK3R1(6), PPP1R13B(1), PTEN(4), RACGAP1(1), RHO(2), ROCK1(8), ROCK2(4), RPS4X(1), WASF1(2), WASL(2)	12935730	109	39	109	22	41	34	15	0	16	3	0.0037	0.018
128	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	AKT1(1), ANXA1(1), GNAS(2), GNGT1(1), NFKB1(4), NR3C1(1), PIK3CA(7), PIK3R1(6)	3160772	23	18	23	7	8	5	6	0	2	2	0.0037	0.018
129	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(1), EIF2B5(3), GSK3B(2), IGF1(1), IGF1R(2), INPPL1(3), PDK2(1), PDPK1(1), PIK3CA(7), PIK3R1(6), PPP2CA(1), PTEN(4)	3601846	32	21	32	6	10	8	9	0	3	2	0.0038	0.018
130	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	GALNT11(1), GALNT12(1), GALNT13(1), GALNT14(4), GALNT2(2), GALNT5(5), GALNT6(1), GALNT7(1), GALNT8(1), GALNTL1(2), GALNTL2(3), GALNTL4(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(3), OGT(2), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(8)	5901578	46	26	46	14	9	19	12	0	6	0	0.0038	0.018
131	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTN1(2), ACTN2(5), ACTN3(1), ACTN4(3), AKT1(1), AKT2(2), AKT3(1), ARHGAP5(4), BIRC2(2), BIRC3(5), BRAF(10), CAPN2(2), CAV1(1), CAV3(1), CCND2(1), CCND3(1), CDC42(1), CHAD(2), COL11A1(8), COL11A2(3), COL1A1(2), COL1A2(6), COL2A1(2), COL3A1(7), COL4A1(5), COL4A2(1), COL4A4(2), COL4A6(5), COL5A1(7), COL5A2(4), COL5A3(6), COL6A2(1), COL6A3(20), COL6A6(5), CTNNB1(8), DOCK1(2), EGFR(5), ERBB2(4), FARP2(2), FIGF(2), FLNA(1), FLNB(6), FLNC(2), FLT1(4), FN1(6), FYN(1), GRB2(2), GRLF1(5), GSK3B(2), HGF(3), IBSP(1), IGF1(1), IGF1R(2), ITGA1(1), ITGA10(4), ITGA11(2), ITGA2(2), ITGA2B(3), ITGA4(5), ITGA5(2), ITGA6(2), ITGA8(3), ITGA9(3), ITGAV(4), ITGB3(2), ITGB4(1), ITGB5(4), ITGB6(2), ITGB7(2), ITGB8(1), KDR(3), LAMA1(7), LAMA2(10), LAMA3(8), LAMA4(6), LAMB1(2), LAMB2(3), LAMB3(1), LAMB4(6), LAMC1(6), LAMC2(4), LAMC3(4), MAP2K1(2), MAPK10(6), MAPK3(1), MAPK8(6), MAPK9(2), MET(1), MYL9(2), MYLK(5), MYLK2(2), PAK1(1), PAK2(3), PAK3(3), PAK7(3), PARVB(2), PDGFC(1), PDGFRA(4), PDGFRB(2), PDPK1(1), PGF(1), PIK3CA(7), PIK3CB(1), PIK3CD(2), PIK3CG(5), PIK3R1(6), PIK3R3(4), PIP5K1C(3), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PRKCA(3), PRKCG(5), PTEN(4), PTK2(1), RAF1(4), RAP1A(1), RAP1B(1), RAPGEF1(2), RELN(13), RHOA(1), ROCK1(8), ROCK2(4), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SOS1(3), SOS2(6), SRC(3), THBS1(3), THBS2(8), THBS3(2), THBS4(1), TLN1(3), TLN2(4), TNC(7), TNN(4), TNR(4), TNXB(4), VAV1(7), VAV2(3), VAV3(3), VCL(2), VEGFC(3), VTN(3), VWF(7), ZYX(1)	66875228	502	87	493	197	174	170	95	5	55	3	0.0038	0.018
132	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(5), GNAS(2), GNGT1(1), PRKACA(1), PRKAR1A(4)	1133258	13	11	13	3	4	5	2	0	2	0	0.0044	0.020
133	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	CABIN1(5), CAMK4(1), CD69(1), CDKN1A(1), CNR1(3), CREBBP(8), CTLA4(1), EGR2(3), EP300(8), FCER1A(3), FCGR3A(1), FOS(1), GATA3(1), GRLF1(5), GSK3B(2), IL10(1), IL1B(1), IL2(2), IL3(1), IL4(1), IL6(2), IL8(1), ITK(4), KPNA5(1), MAPK8(6), MAPK9(2), MEF2A(1), MYF5(2), NFATC1(1), NFATC2(3), NFATC3(1), NFATC4(2), NFKB2(2), NPPB(1), NUP214(3), P2RX7(1), PAK1(1), PIN1(1), PPP3CB(2), PPP3CC(3), PTPRC(9), SLA(1), SP1(1), SP3(2), TGFB1(1), TRPV6(4), VAV1(7), VAV2(3), VAV3(3), XPO5(1)	16324112	122	39	122	34	43	40	19	2	18	0	0.0045	0.021
134	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(5), AKT1(1), CSF2RB(1), IGF1(1), IGF1R(2), IL3(1), KIT(2), KITLG(1), PIK3CA(7), PIK3R1(6), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), YWHAH(1)	3825342	35	22	35	16	13	11	7	0	2	2	0.0050	0.023
135	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(2), BMPR1A(1), BMPR1B(1), BMPR2(8)	1130000	12	9	12	2	2	4	3	0	3	0	0.0056	0.025
136	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(1), AKT2(2), AKT3(1), GRB2(2), GSK3B(2), IRS1(4), JAK1(1), JAK3(4), MAP4K1(1), MAPK3(1), PDK1(2), PIK3CA(7), PIK3CD(2), PIK3R1(6), PPP1R13B(1), RAF1(4), SHC1(1), SOS1(3), SOS2(6), STAT6(1)	6407790	52	26	52	9	13	20	11	0	6	2	0.0060	0.027
137	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(1), EIF4A2(1), EIF4G1(3), EIF4G3(7), GHR(1), IRS1(4), MAPK3(1), MKNK1(1), PDK2(1), PDPK1(1), PIK3CA(7), PIK3R1(6), PRKCA(3), PTEN(4)	5081078	41	24	41	8	9	12	11	1	6	2	0.0065	0.029
138	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(1), BCR(2), FOS(1), GRB2(2), JAK2(4), MAP2K1(2), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(6), PIK3CA(7), PIK3R1(6), RAF1(4), SOS1(3), STAT1(1), STAT5B(1)	4994214	45	23	45	6	11	13	13	1	4	3	0.0067	0.030
139	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(4), FYN(1), ITGA1(1), MAP2K1(2), MAPK3(1), MYLK(5), PIK3CA(7), PIK3R1(6), PTK2(1), RAF1(4), ROCK1(8), SHC1(1), SRC(3), TLN1(3)	6956728	47	26	47	11	14	16	10	0	5	2	0.0068	0.030
140	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(3), NR1I3(2), PTGS1(4), PTGS2(1)	964354	12	10	12	5	4	4	3	0	1	0	0.0078	0.034
141	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(8), ABCA10(4), ABCA12(20), ABCA13(17), ABCA3(1), ABCA4(5), ABCA5(3), ABCA6(7), ABCA7(1), ABCA8(7), ABCA9(7), ABCB1(6), ABCB10(1), ABCB11(3), ABCB4(6), ABCB5(5), ABCB6(2), ABCB7(1), ABCB8(1), ABCC1(3), ABCC10(1), ABCC11(3), ABCC12(5), ABCC2(5), ABCC3(2), ABCC4(3), ABCC5(2), ABCC6(2), ABCC8(3), ABCC9(6), ABCD1(1), ABCD2(3), ABCD4(1), ABCG1(2), ABCG2(5), ABCG5(1), ABCG8(2), CFTR(5), TAP1(3), TAP2(2)	21243252	165	40	165	50	43	66	33	2	20	1	0.0080	0.035
142	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(1), GHR(1), GRB2(2), INSR(1), IRS1(4), JAK2(4), MAP2K1(2), MAPK3(1), PIK3CA(7), PIK3R1(6), PLCG1(1), PRKCA(3), RAF1(4), SHC1(1), SLC2A4(2), SOS1(3), STAT5B(1)	5963568	44	24	44	12	11	13	11	0	6	3	0.0081	0.035
143	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), ATF1(1), CDC42(1), CREB3(2), CREB5(2), DUSP1(2), DUSP10(3), EEF2K(1), IL1R1(1), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K10(1), MAP3K4(8), MAP3K5(3), MAP3K7(2), MAPK13(1), MKNK1(1), MKNK2(1), MYEF2(2), NFKB1(4), NR2C2(1), TRAF6(1)	6061708	46	26	46	11	16	10	12	2	6	0	0.0082	0.035
144	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(1), GRB2(2), MAPK3(1), MEF2A(1), MEF2C(2), NTRK1(3), PIK3CA(7), PIK3R1(6), PLCG1(1), SHC1(1)	3588620	25	18	25	6	4	8	7	0	4	2	0.0086	0.036
145	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QB(1), C1R(1), C1S(4), C2(4), C3(2), C5(5), C6(6), C7(3), C8A(4), C8B(3), C9(2), MASP1(5)	3779342	40	19	40	8	14	15	5	0	6	0	0.0086	0.036
146	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(2), ADH1C(1), ADH4(2), ADH6(2), ADH7(1), ADHFE1(3)	1028826	12	10	12	5	3	4	4	0	1	0	0.0087	0.037
147	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), CARS(3), DARS(3), EPRS(4), FARS2(3), IARS(3), LARS(1), LARS2(1), MARS(4), MARS2(1), NARS(2), QARS(3), RARS(3), SARS(1), TARS(4), WARS(1), WARS2(2), YARS(1)	5850140	42	24	42	8	9	15	11	2	5	0	0.010	0.042
148	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(2), IL6R(1), JAK1(1), JAK2(4), JAK3(4), PIAS3(2), PTPRU(6), REG1A(2), SRC(3), STAT3(1)	2809828	26	18	26	7	14	8	1	0	2	1	0.011	0.044
149	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(1), AKT2(2), AKT3(1), BCR(2), BLNK(1), BTK(2), CD19(1), CD22(4), CR2(3), CSK(2), DAG1(3), GRB2(2), GSK3B(2), INPP5D(2), ITPR1(8), ITPR2(6), ITPR3(7), MAP4K1(1), MAPK3(1), NFATC1(1), NFATC2(3), PDK1(2), PIK3CA(7), PIK3CD(2), PIK3R1(6), PLCG2(4), PPP1R13B(1), PPP3CA(2), PPP3CB(2), PPP3CC(3), PTPRC(9), RAF1(4), SHC1(1), SOS1(3), SOS2(6), SYK(3), VAV1(7)	13357390	117	38	117	17	39	41	18	0	16	3	0.011	0.045
150	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11A1(3), CYP11B1(4), CYP21A2(1), HSD3B1(1), HSD3B2(1)	1612278	12	11	12	4	4	5	1	0	2	0	0.011	0.045
151	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(1), CYP11A1(3), CYP11B1(4), CYP21A2(1), HSD3B1(1), HSD3B2(1)	1612278	12	11	12	4	4	5	1	0	2	0	0.011	0.045
152	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	GNAQ(1), GRB2(2), MAP2K1(2), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(6), PAK1(1), PLCG1(1), PRKCA(3), PTK2B(1), RAF1(4), SHC1(1), SOS1(3), SRC(3)	5147972	38	21	38	12	9	13	9	2	5	0	0.011	0.046
153	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(5), CAP1(1), CDC25C(1), GNAI1(1), GNAS(2), GNGT1(1), MAPK3(1), MYT1(9), PIN1(1), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), SRC(3)	3678224	33	22	33	11	11	14	5	0	3	0	0.012	0.046
154	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP4A(1), INPP4B(2), INPPL1(3), OCRL(6), PIK3C2A(3), PIK3C2B(6), PIK3C2G(2), PIK3CA(7), PIK3CB(1), PIK3CG(5), PLCB1(1), PLCB3(3), PLCB4(2), PLCD1(4), PLCG1(1), PLCG2(4)	8239100	52	31	52	19	15	21	11	1	4	0	0.012	0.046
155	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(2), ACTN1(2), ACTR2(1), ACTR3(1), AKT1(1), AKT2(2), AKT3(1), ANGPTL2(4), ARHGEF6(3), ARHGEF7(3), BRAF(10), CAV1(1), CDC42(1), DOCK1(2), EPHB2(3), FYN(1), GRB2(2), GRLF1(5), ITGA1(1), ITGA10(4), ITGA11(2), ITGA2(2), ITGA4(5), ITGA5(2), ITGA6(2), ITGA8(3), ITGA9(3), ITGB3BP(3), MAP2K4(2), MAP3K11(1), MAPK10(6), MAPK8(6), MAPK8IP3(1), MAPK9(2), MRAS(1), MYLK(5), MYLK2(2), PAK1(1), PAK2(3), PAK3(3), PAK7(3), PIK3CA(7), PIK3CB(1), PLCG1(1), PLCG2(4), PTEN(4), PTK2(1), RAF1(4), RALA(1), RHO(2), ROCK1(8), ROCK2(4), SHC1(1), SOS1(3), SOS2(6), SRC(3), TERF2IP(2), TLN1(3), TLN2(4), ZYX(1)	22280652	168	47	161	64	48	51	43	3	23	0	0.012	0.046
156	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMA7(1), PSMB3(1), PSMB5(2), PSMB6(1), PSMB8(3)	1509738	12	10	12	4	3	5	1	1	2	0	0.012	0.046
157	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(2), BCL10(1), BCL2L11(2), BID(1), CASP8AP2(6), CASP9(1), CES1(2)	2093652	15	12	15	5	2	7	2	0	4	0	0.013	0.049
158	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(2), ARHGAP5(4), ARHGDIB(1), CASP10(1), CASP3(1), CASP8(5), CASP9(1), GZMB(2)	2347710	17	13	17	6	1	5	7	0	4	0	0.013	0.050
159	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA3(1), ANXA4(1), ANXA6(1), CYP11A1(3), EDNRA(1), EDNRB(5), PLA2G4A(4), PRL(1), PTGDR(1), PTGFR(3), PTGIS(2), PTGS1(4), PTGS2(1), TBXAS1(3)	3739524	32	21	32	8	12	9	8	0	3	0	0.013	0.051
160	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(1), BRAF(10), CHUK(4), DAXX(1), FOS(1), GRB2(2), IKBKB(2), MAP2K1(2), MAP2K2(1), MAP2K3(4), MAP2K4(2), MAP2K5(2), MAP2K6(1), MAP3K1(2), MAP3K10(1), MAP3K11(1), MAP3K12(2), MAP3K13(1), MAP3K14(1), MAP3K2(1), MAP3K3(2), MAP3K4(8), MAP3K5(3), MAP3K6(2), MAP3K7(2), MAP3K8(1), MAP3K9(4), MAP4K1(1), MAP4K2(1), MAP4K3(1), MAP4K4(3), MAPK10(6), MAPK13(1), MAPK3(1), MAPK6(1), MAPK8(6), MAPK9(2), MEF2A(1), MEF2C(2), MKNK1(1), MKNK2(1), NFKB1(4), PAK1(1), PAK2(3), RAF1(4), RPS6KA2(4), RPS6KA3(2), RPS6KA5(4), RPS6KB2(1), SHC1(1), SP1(1), STAT1(1), TGFB1(1), TGFB2(4), TGFBR1(5)	17599482	128	42	121	32	30	36	40	2	20	0	0.014	0.054
161	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CAPN2(2), EP300(8), HDAC1(2), NFATC1(1), NFATC2(3), PPP3CA(2), PPP3CB(2), PPP3CC(3), PRKCA(3)	4237302	31	22	31	6	12	8	5	1	5	0	0.014	0.054
162	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ACTR3(1), ARHGAP5(4), ARHGAP6(2), ARHGEF1(2), ARHGEF11(6), ARHGEF5(1), ARPC1B(1), ARPC2(1), BAIAP2(1), LIMK1(2), MYLK(5), OPHN1(6), PIP5K1B(1), PPP1R12B(4), ROCK1(8), SRC(3), TLN1(3), VCL(2)	8496328	54	26	54	14	16	16	11	1	10	0	0.015	0.056
163	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BRAF(10), CREB3(2), CREB5(2), DUSP6(3), EEF2K(1), GRB2(2), MAP2K1(2), MAP2K2(1), MAP3K8(1), MAPK3(1), MKNK1(1), MKNK2(1), MOS(1), NFKB1(4), RAP1A(1), RPS6KA2(4), RPS6KA3(2), SHC1(1), SOS1(3), SOS2(6), TRAF3(2)	5432566	52	24	45	6	12	16	17	1	6	0	0.015	0.056
164	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(11), ASH2L(1), CARM1(1), CTCFL(2), EHMT2(3), EZH1(2), EZH2(1), FBXO11(2), HSF4(1), MEN1(2), MLL(10), MLL2(3), MLL3(8), MLL4(3), MLL5(7), NSD1(4), OGT(2), PAXIP1(1), PPP1CB(1), PPP1CC(1), PRDM2(8), PRDM7(1), PRDM9(6), PRMT1(1), PRMT7(2), PRMT8(2), SATB1(1), SETD1A(3), SETD2(11), SETD7(2), SETDB1(4), SETDB2(3), SETMAR(1), SMYD3(2), STK38(1), SUV39H1(1), SUV39H2(1), SUV420H1(5), SUZ12(1), WHSC1(4), WHSC1L1(1)	21920454	127	37	127	26	38	37	23	2	26	1	0.015	0.057
165	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(4), ARHGEF1(2), GNAQ(1), GNGT1(1), MYLK(5), PLCB1(1), PPP1R12B(4), PRKCA(3), ROCK1(8)	3811716	29	17	29	8	8	10	5	1	5	0	0.016	0.059
166	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QB(1), C1R(1), C1S(4), C2(4), C3(2), C5(5), C6(6), C7(3), C8A(4), C9(2), MASP1(5), MASP2(2)	3894290	39	19	39	9	13	14	6	0	6	0	0.016	0.061
167	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), HBXIP(1), PTK2B(1), SHC1(1), SOS1(3), SRC(3)	1600118	11	9	11	4	1	5	3	0	2	0	0.017	0.062
168	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	86	CD44(2), CHAD(2), COL11A1(8), COL11A2(3), COL1A1(2), COL1A2(6), COL2A1(2), COL3A1(7), COL4A1(5), COL4A2(1), COL4A4(2), COL4A6(5), COL5A1(7), COL5A2(4), COL5A3(6), COL6A2(1), COL6A3(20), COL6A6(5), DAG1(3), FN1(6), FNDC1(8), FNDC3A(4), GP5(2), GP6(1), HMMR(4), HSPG2(1), IBSP(1), ITGA1(1), ITGA10(4), ITGA11(2), ITGA2(2), ITGA2B(3), ITGA4(5), ITGA5(2), ITGA6(2), ITGA8(3), ITGA9(3), ITGAV(4), ITGB3(2), ITGB4(1), ITGB5(4), ITGB6(2), ITGB7(2), ITGB8(1), LAMA1(7), LAMA2(10), LAMA3(8), LAMA4(6), LAMB1(2), LAMB2(3), LAMB3(1), LAMB4(6), LAMC1(6), LAMC2(4), LAMC3(4), RELN(13), SDC1(1), SDC2(3), SDC3(1), SDC4(1), SV2A(1), SV2B(4), THBS1(3), THBS2(8), THBS3(2), THBS4(1), TNC(7), TNN(4), TNR(4), TNXB(4), VTN(3), VWF(7)	40496776	285	66	285	130	100	99	47	5	33	1	0.017	0.062
169	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(1), CDC25B(2), CDC25C(1), CSK(2), GRB2(2), PRKCA(3), PTPRA(1), SRC(3)	1701282	15	13	15	3	5	8	1	1	0	0	0.018	0.064
170	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(1), CABIN1(5), CAMK1(2), CAMK1G(3), HDAC5(1), IGF1(1), IGF1R(2), INSR(1), MAP2K6(1), MEF2A(1), MEF2C(2), NFATC1(1), NFATC2(3), PIK3CA(7), PIK3R1(6), PPP3CA(2), PPP3CB(2), PPP3CC(3), YWHAH(1)	6186826	45	26	45	16	15	12	7	0	9	2	0.018	0.064
171	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(4), DAG1(3), DGKA(1), ETFA(1), ITGA9(3), ITPR1(8), ITPR2(6), ITPR3(7), MAP2K1(2), MAPK3(1), NR1I3(2), PAK1(1), PDE3A(1), PDE3B(1), PI3(1), PIK3C2G(2), PIK3CA(7), PIK3CD(2), PIK3R1(6), RIPK3(1), RPS4X(1), SGCB(4)	9058946	68	31	68	14	22	20	14	0	8	4	0.019	0.069
172	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(3), EIF2B2(1), EIF2B5(3), FLT1(4), FLT4(1), HIF1A(3), KDR(3), PIK3CA(7), PIK3R1(6), PLCG1(1), PRKCA(3), PTK2(1), SHC1(1), VHL(1)	6026028	38	24	38	14	10	11	10	0	5	2	0.019	0.069
173	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(2), FMOD(1), KERA(4), LUM(2)	666536	10	8	10	1	4	2	3	0	1	0	0.019	0.069
174	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(2), BMP5(3), BMP6(1), BMP7(2), BTRC(3), CSNK1D(2), CSNK1G3(1), FBXW11(4), GLI1(2), GLI2(2), GLI3(6), GSK3B(2), HHIP(2), IHH(1), LRP2(25), PRKACA(1), PRKACG(1), PTCH1(4), PTCH2(3), RAB23(1), SMO(1), STK36(2), SUFU(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(1), WNT2B(2), WNT3(1), WNT4(1), WNT6(1), WNT8A(1), WNT9B(2)	10616388	86	37	85	30	38	27	11	0	10	0	0.020	0.069
175	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(1), HGD(2)	368276	5	4	5	1	1	2	1	0	1	0	0.021	0.074
176	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT4(4), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(7), ENPP6(1), PAFAH1B3(2), PAFAH2(1), PLA2G4A(4), PLA2G6(2), PLD1(6), PLD2(1)	4249468	32	19	32	13	15	12	2	0	3	0	0.022	0.078
177	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), GNAI1(1), GNGT1(1), ITGA1(1), MAP2K1(2), MAPK3(1), PLA2G4A(4), PLCB1(1), PRKCA(3), PTGS1(4), PTK2(1), RAF1(4), SRC(3), SYK(3), TBXAS1(3)	4439922	34	21	34	11	11	12	4	1	6	0	0.023	0.078
178	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(4), ADORA2A(2), ADORA2B(1), LTB4R(1), P2RY1(4), P2RY2(1), P2RY6(1)	976514	14	9	14	0	6	6	1	0	1	0	0.023	0.079
179	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(1), CALCR(4), CALCRL(4), CD97(2), CRHR1(1), CRHR2(2), ELTD1(2), EMR1(4), EMR2(5), GHRHR(1), GLP1R(5), GLP2R(4), GPR64(3), LPHN1(2), LPHN2(5), LPHN3(7), VIPR1(3), VIPR2(1)	5078806	56	25	56	17	24	18	10	0	4	0	0.023	0.079
180	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(5), FOS(1), GNAI1(1), GNAQ(1), GNAS(2), GNGT1(1), MAP2K1(2), MAPK3(1), NFATC1(1), NFATC2(3), NFATC3(1), NFATC4(2), PLCG1(1), PPP3CA(2), PPP3CB(2), PPP3CC(3), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), PRKCA(3), RAF1(4), RPS6KA3(2)	6131546	45	26	45	12	19	13	6	0	7	0	0.026	0.090
181	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(3), CBS(2), CTH(1), DNMT1(11), DNMT3A(6), DNMT3B(5), MARS(4), MARS2(1), MAT1A(2), MAT2B(1), MTR(1)	3186640	37	19	36	8	16	12	3	2	4	0	0.026	0.090
182	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(1), CBL(4), CFLAR(1), FOS(1), GRB2(2), IL2RB(1), IRS1(4), JAK1(1), JAK3(4), MAPK3(1), NMI(1), PIK3CA(7), PIK3R1(6), RAF1(4), SHC1(1), SOS1(3), STAT5B(1), SYK(3)	6442176	46	23	46	10	10	18	8	0	8	2	0.029	0.098
183	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1B(2), ADH1C(1), ADH4(2), ADH6(2), ADH7(1), ADHFE1(3), AGK(2), AGPAT1(1), AGPAT4(4), AGPAT6(1), AKR1B1(1), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH7A1(2), DAK(2), DGAT2(3), DGKA(1), DGKB(2), DGKD(8), DGKE(2), DGKG(2), DGKH(7), DGKI(7), DGKZ(1), GK(1), GK2(5), GLA(1), GPAM(1), LCT(11), LIPC(1), LIPF(2), LPL(2), MGLL(1), PNLIP(3), PNLIPRP1(1), PNLIPRP2(1)	10636222	97	37	97	22	38	33	19	0	7	0	0.031	0.10
184	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QB(1), C1R(1), C1S(4), C2(4), C3(2), C5(5), C6(6), C7(3), C8A(4), C9(2)	3177600	32	15	32	6	10	12	5	0	5	0	0.031	0.11
185	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), IL2(2), IL4(1), TGFB1(1), TGFB2(4), TGFBR1(5), TGFBR2(2), TGFBR3(3), TOB1(2)	1961202	21	10	21	4	5	8	3	0	5	0	0.033	0.11
186	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(5), ACADL(2), ACADM(4), ALDH1A1(1), ALDH1A2(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH6A1(2), ECHS1(1), HADHA(1), LDHA(2), LDHB(2), LDHC(1), MCEE(1), MUT(2), PCCA(7), PCCB(3), SDS(1), SUCLA2(3), SUCLG1(1)	6060462	52	23	52	13	18	17	6	0	11	0	0.033	0.11
187	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(2), CD79A(1), CD79B(1), FOS(1), GRB2(2), MAP2K1(2), MAP3K1(2), MAPK3(1), MAPK8(6), NFATC1(1), NFATC2(3), NFATC3(1), NFATC4(2), PLCG1(1), PPP3CA(2), PPP3CB(2), PPP3CC(3), PRKCA(3), RAF1(4), SHC1(1), SOS1(3), SYK(3), VAV1(7)	6854016	55	25	55	10	17	19	9	1	9	0	0.036	0.12
188	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(1), AKT2(2), AKT3(1), BCR(2), BLNK(1), BTK(2), CD19(1), CSK(2), DAG1(3), EPHB2(3), GRB2(2), MAP2K1(2), MAP2K2(1), NFKB1(4), NFKB2(2), PI3(1), PIK3CA(7), PIK3CD(2), PIK3R1(6), PLCG2(4), PPP1R13B(1), RAF1(4), SERPINA4(5), SHC1(1), SOS1(3), SOS2(6), SYK(3), VAV1(7)	9331908	79	31	79	16	29	24	15	1	8	2	0.036	0.12
189	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(1), ADH1B(2), ADH1C(1), ADH4(2), ADH6(2), ADH7(1), ADHFE1(3), ALDH1A3(4), ALDH3B1(1), ALDH3B2(1), AOC2(1), AOC3(1), AOX1(3), DBH(2), DCT(7), FAH(2), GOT1(2), GSTZ1(1), HGD(2), HPD(2), MAOA(3), MAOB(1), TAT(3), TPO(4), TYR(1)	5699128	53	27	53	24	14	25	8	0	6	0	0.036	0.12
190	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(4), CREBBP(8), DUSP1(2), EP300(8), IKBKB(2), IL1B(1), IL8(1), MAP2K3(4), MAP2K6(1), MAP3K14(1), MAP3K7(2), MYD88(1), NFKB1(4), NR3C1(1), TGFBR1(5), TGFBR2(2), TLR2(4)	5396954	51	21	51	16	14	15	13	2	7	0	0.037	0.12
191	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(1), AKT2(2), AKT3(1), GRB2(2), IARS(3), IL13RA1(2), IL4(1), INPP5D(2), JAK1(1), JAK2(4), JAK3(4), PI3(1), PIK3CA(7), PPP1R13B(1), SERPINA4(5), SHC1(1), SOS1(3), SOS2(6), SRC(3), STAT6(1)	6748788	51	26	51	12	10	22	12	1	5	1	0.039	0.13
192	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(1), HADH(1), HADHA(1), HADHB(1), HSD17B10(1), HSD17B4(1), MECR(1), PPT2(1)	1526816	9	8	9	5	2	2	2	0	3	0	0.040	0.13
193	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(8), EP300(8), ESR1(3), MAPK3(1), SRC(3)	2797134	23	16	23	5	7	9	2	2	3	0	0.041	0.13
194	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(3), NFYC(1), RB1(3), SP1(1), SP3(2)	1223664	10	8	10	2	3	5	1	0	1	0	0.042	0.13
195	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(4), GABRA1(2), GABRA2(3), GABRA3(3), GABRA4(2), GABRA5(1), GABRA6(1), GPHN(5), SRC(3)	2209072	24	14	24	9	6	14	3	0	1	0	0.043	0.14
196	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(17), B3GALT4(1), CDR1(2), DGKI(7), FAU(1), IL6ST(1), PIGK(3), RPL10(1), RPL11(1), RPL19(1), RPL28(1), RPL5(1), RPL6(2), RPL9(2), RPS16(1), RPS18(1), RPS2(1), RPS3(1), RPS4X(1), RPS6KA2(4), RPS6KA3(2), RPS6KA6(3), RPS6KB2(1), RPS9(1), SLC36A2(1), TSPAN9(1), UBB(1)	9436574	60	29	60	16	22	16	13	2	7	0	0.044	0.14
197	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(1), AKT2(2), AKT3(1), CDKN1A(1), GRB2(2), MAP2K1(2), MAP2K2(1), NGFR(1), NTRK1(3), PIK3CA(7), PIK3CD(2), SHC1(1), SOS1(3)	2945316	27	16	27	6	5	11	10	0	1	0	0.046	0.14
198	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ACTA1(1), ACTA2(1), ADCY1(5), ADCY2(8), ADCY3(2), ADCY4(2), ADCY5(6), ADCY7(2), ADCY8(3), ADCY9(2), ATF1(1), ATF2(1), ATF4(1), ATP2A2(3), ATP2A3(1), CACNB3(1), CALCA(1), CAMK2D(2), CNN1(1), CNN2(1), CORIN(4), CREB3(2), CRHR1(1), DGKZ(1), ETS2(1), FOS(1), GABPB2(1), GBA2(1), GJA1(4), GNAQ(1), GNB3(2), GNB4(1), GNG3(1), GNG4(1), GNGT1(1), GRK4(1), GRK5(1), GSTO1(1), GUCY1A3(5), IGFBP3(3), IGFBP4(1), IL1B(1), IL6(2), ITPR1(8), ITPR2(6), ITPR3(7), MIB1(3), MYL4(1), MYLK2(2), NFKB1(4), NOS1(6), OXTR(1), PDE4B(3), PDE4D(1), PLCB3(3), PLCD1(4), PLCG1(1), PLCG2(4), PRKACA(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), PRKCA(3), PRKCE(2), PRKCH(1), PRKCQ(2), PRKD1(5), RAMP3(1), RGS1(1), RGS17(2), RGS2(3), RGS20(1), RGS3(3), RGS4(2), RGS5(1), RGS7(4), RGS9(3), RLN1(1), RYR1(11), RYR2(11), RYR3(11), SLC8A1(4), SP1(1), TNXB(4), USP5(2), YWHAH(1)	31604422	224	63	224	88	79	94	26	1	23	1	0.048	0.15
199	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(4)	132248	4	3	4	0	3	1	0	0	0	0	0.050	0.16
200	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), AKT3(1), CAPN10(1), CAPN11(1), CAPN2(2), CAPN3(4), CAPN5(1), CAPN6(3), CAPN7(2), CAPN9(1), CAV1(1), CAV3(1), CDC42(1), CSK(2), DOCK1(2), FYN(1), GIT2(1), GRB2(2), ITGA10(4), ITGA11(2), ITGA2(2), ITGA2B(3), ITGA4(5), ITGA5(2), ITGA6(2), ITGA8(3), ITGA9(3), ITGAD(2), ITGAE(3), ITGAL(4), ITGAM(3), ITGAV(4), ITGAX(2), ITGB2(2), ITGB3(2), ITGB4(1), ITGB5(4), ITGB6(2), ITGB7(2), ITGB8(1), MAP2K1(2), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAPK10(6), MAPK6(1), MYLK2(2), PAK1(1), PAK2(3), PAK3(3), PDPK1(1), PTK2(1), RAP1B(1), RAPGEF1(2), RHO(2), ROCK1(8), ROCK2(4), SEPP1(1), SHC1(1), SHC3(1), SORBS1(7), SOS1(3), SRC(3), TLN1(3), TNS1(4), VAV2(3), VAV3(3), VCL(2), ZYX(1)	24804036	161	47	161	59	46	62	29	5	19	0	0.052	0.16
201	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP2(1), ACPP(2), ALPPL2(1), CYP19A1(6), CYP1A1(2), CYP1A2(2), CYP2A13(3), CYP2A6(3), CYP2C18(2), CYP2C8(2), CYP2C9(5), CYP2E1(3), CYP2F1(1), CYP2J2(3), CYP3A7(3), CYP4B1(3), PON1(1)	5330408	43	24	43	8	16	7	15	0	4	1	0.054	0.17
202	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(1), JAK2(4), JAK3(4), PIAS1(1), PIAS3(2), PTPRU(6), REG1A(2)	2548460	20	13	20	3	9	6	2	0	2	1	0.055	0.17
203	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(5), CFTR(5), GNAS(2), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), SLC9A3R1(1)	2299392	20	13	20	5	6	8	3	0	3	0	0.055	0.17
204	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(2), BID(1), BIRC2(2), BIRC3(5), CASP3(1), CASP6(2), CASP7(1), CASP8(5), CASP9(1), DFFA(2), DFFB(1)	2480842	23	13	23	4	4	9	4	0	6	0	0.059	0.18
205	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(1), BHMT(3), CBS(2), CTH(1), DNMT1(11), DNMT3A(6), DNMT3B(5), MARS(4), MARS2(1), MAT1A(2), MAT2B(1), MTAP(1), MTFMT(1), MTR(1), TAT(3)	3800838	43	20	42	8	16	18	3	2	4	0	0.060	0.18
206	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(1), EIF4A2(1), EIF4B(1), EIF4G1(3), EIF4G3(7), MKNK1(1), PDK2(1), PDPK1(1), PIK3CA(7), PIK3R1(6), PPP2CA(1), PTEN(4), TSC1(2), TSC2(1)	4950094	37	21	37	8	8	10	11	1	5	2	0.060	0.18
207	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(2), BCL2A1(3), BOK(1), CASP10(1), CASP2(1), CASP3(1), CASP4(2), CASP6(2), CASP7(1), CASP8(5), CASP9(1), CD40(1), CD40LG(4), CRADD(1), DAXX(1), DFFA(2), DFFB(1), FAS(2), IKBKE(1), NFKB1(4), NGFR(1), NR3C1(1), NTRK1(3), PTPN13(9), SFRS2IP(3), TFG(1), TRAF1(1), TRAF3(2), TRAF6(1)	7996996	59	26	59	24	13	22	12	0	12	0	0.060	0.18
208	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(3), CTH(1), GOT1(2), LDHA(2), LDHB(2), LDHC(1)	1206468	11	7	11	2	4	4	1	0	2	0	0.061	0.18
209	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(1), AKT2(2), AKT3(1), CAP1(1), CBL(4), CDC42(1), F2RL2(1), GRB2(2), GSK3B(2), INPPL1(3), IRS1(4), IRS4(8), LNPEP(4), MAPK3(1), PARD3(4), PARD6A(2), PDK1(2), PIK3CA(7), PIK3CD(2), PIK3R1(6), PPYR1(3), PTEN(4), PTPN1(4), RAF1(4), RPS6KA2(4), RPS6KA3(2), SERPINB6(1), SHC1(1), SLC2A4(2), SORBS1(7), SOS1(3), SOS2(6), YWHAH(1)	10403392	100	32	100	20	34	29	22	1	12	2	0.062	0.18
210	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(5), GNAS(2), GNGT1(1), PPP2CA(1), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKACG(1), PRKAG2(2), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1)	2738406	24	16	24	6	12	6	4	0	2	0	0.066	0.19
211	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ACMSD(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), AOC2(1), AOC3(1), AOX1(3), CAT(1), CYP19A1(6), CYP1A1(2), CYP1A2(2), CYP2A13(3), CYP2A6(3), CYP2C18(2), CYP2C8(2), CYP2C9(5), CYP2E1(3), CYP2F1(1), CYP2J2(3), CYP3A7(3), CYP4B1(3), ECHS1(1), GCDH(3), HADHA(1), KMO(2), KYNU(2), MAOA(3), MAOB(1), SDS(1), TDO2(2), TPH1(2), WARS(1), WARS2(2)	9962500	79	34	79	24	27	25	19	0	8	0	0.066	0.19
212	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(5), CPT1A(3), LEPR(5), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKAG2(2)	2663918	21	12	21	11	9	6	4	0	2	0	0.073	0.21
213	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(1), CHKA(2), PCYT1A(2), PDHA1(1), PDHA2(4), PEMT(1), SLC18A3(1)	1282068	14	11	14	8	3	4	6	0	1	0	0.078	0.23
214	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(2), F3(1), F5(10), F7(1), FGA(6), FGB(1), FGG(2), PROS1(3), SERPINC1(1), TFPI(3)	2937700	30	13	30	8	6	13	8	0	3	0	0.080	0.23
215	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(1), ACAD9(4), ADH1A(1), ADH1B(2), ADH1C(1), ADH4(2), ADH6(2), ADH7(1), ADHFE1(3), DHRS1(1), DHRS2(1), DHRS3(1), ESCO1(6), ESCO2(1), MYST3(10), MYST4(7), SH3GLB1(1)	4454936	45	20	45	16	14	13	14	1	3	0	0.082	0.23
216	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(2), DLG4(1), EPHB2(3), F2(2), F2RL1(1), F2RL2(1), MAP2K5(2), MAPK8(6), MYEF2(2), PLD1(6), PLD2(1), PLD3(1), PTK2(1), RAF1(4), RASAL1(2), SRC(3), TEC(2), VAV1(7)	5090624	47	22	47	11	16	19	7	1	4	0	0.082	0.23
217	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), GAD1(2), HDC(5), TPH1(2)	1044528	11	8	11	8	3	5	2	0	1	0	0.083	0.23
218	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CREBBP(8), CSK(2), GNAS(2), GNGT1(1), HLA-DRA(3), HLA-DRB1(1), LCK(2), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), PTPRC(9), ZAP70(1)	4078142	41	19	41	8	15	15	6	0	5	0	0.083	0.23
219	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CREBBP(8), CSK(2), GNAS(2), GNGT1(1), HLA-DRA(3), HLA-DRB1(1), LCK(2), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), PTPRC(9), ZAP70(1)	4078142	41	19	41	8	15	15	6	0	5	0	0.083	0.23
220	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), AARS2(1), CARS(3), DARS(3), DARS2(1), EPRS(4), FARS2(3), FARSB(2), HARS2(3), IARS(3), IARS2(1), LARS(1), LARS2(1), MARS(4), MARS2(1), MTFMT(1), NARS(2), NARS2(3), QARS(3), RARS(3), RARS2(2), SARS(1), TARS(4), TARS2(2), VARS2(2), WARS(1), WARS2(2), YARS(1), YARS2(2)	9549860	62	28	61	16	17	22	15	2	6	0	0.083	0.23
221	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(1), AKT2(2), AKT3(1), CDC42(1), CDKN1B(2), CREB3(2), CREB5(2), EBP(1), ERBB4(7), F2RL2(1), GAB1(1), GRB2(2), GSK3B(2), IGF1(1), INPPL1(3), IRS1(4), IRS4(8), MET(1), NOLC1(2), PAK1(1), PAK2(3), PAK3(3), PAK7(3), PARD3(4), PARD6A(2), PDK1(2), PIK3CA(7), PIK3CD(2), PPP1R13B(1), PREX1(4), PTEN(4), PTK2(1), PTPN1(4), RPS6KA2(4), RPS6KA3(2), SHC1(1), SLC2A4(2), SOS1(3), SOS2(6), TSC1(2), TSC2(1), YWHAH(1)	13570206	107	35	107	40	31	38	21	1	16	0	0.084	0.23
222	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(1), IL4(1), MAF(1), MAP2K3(4), NFATC1(1), NFATC2(3), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1)	2004754	18	13	18	6	10	4	2	1	1	0	0.086	0.24
223	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(2), ARHGDIB(1), BIRC2(2), BIRC3(5), CASP10(1), CASP2(1), CASP3(1), CASP4(2), CASP6(2), CASP7(1), CASP8(5), CASP9(1), DFFA(2), DFFB(1), GZMB(2), LMNB1(3)	3503922	32	16	31	9	6	12	6	0	8	0	0.087	0.24
224	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ADH1A(1), ADH1B(2), ADH1C(1), ADH4(2), ADH6(2), ADH7(1), ADHFE1(3), ALDH1A3(4), ALDH3B1(1), ALDH3B2(1), AOC2(1), AOC3(1), AOX1(3), CARM1(1), DBH(2), DCT(7), ESCO1(6), ESCO2(1), FAH(2), GOT1(2), GSTZ1(1), HGD(2), HPD(2), LCMT1(2), MAOA(3), MAOB(1), METTL2B(1), METTL6(3), MYST3(10), MYST4(7), PRMT3(1), PRMT7(2), PRMT8(2), SH3GLB1(1), TAT(3), TPO(4), TYR(1), TYRP1(1), WBSCR22(1)	10738052	92	35	92	34	28	35	17	3	9	0	0.087	0.24
225	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ADC(1), ALDH4A1(1), ALDH5A1(2), CAD(4), CPS1(7), EPRS(4), GAD1(2), GAD2(2), GFPT1(3), GFPT2(1), GLUD2(3), GLUL(2), GOT1(2), GPT2(1), GSS(1), NADSYN1(1), NAGK(1), PPAT(5), QARS(3)	7196566	47	27	47	15	15	18	8	3	3	0	0.088	0.24
226	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(3), CTH(1), GOT1(2), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHB(2), LDHC(1), SDS(1), SULT1B1(1), SULT1C2(1), SULT1C4(2)	2269768	19	9	18	4	7	5	3	1	3	0	0.091	0.25
227	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(3), CCNE1(1), CUL1(5), RB1(3), TFDP1(1)	1604310	13	9	13	6	4	1	4	0	4	0	0.094	0.26
228	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(3), DNMT1(11), PTGDR(1), PTGFR(3)	1957196	18	14	17	2	8	4	4	2	0	0	0.098	0.26
229	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(2), ENO3(2), FARS2(3), GOT1(2), PAH(1), TAT(3), YARS(1)	1514374	14	9	14	5	4	7	1	0	2	0	0.100	0.27
230	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10B(3), ALG11(1), ALG12(1), ALG14(1), ALG2(1), ALG5(1), ALG6(1), ALG8(3), ALG9(1), B4GALT1(2), B4GALT3(3), DAD1(2), DDOST(1), DHDDS(1), DPAGT1(1), FUT8(2), GANAB(1), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN1C1(3), MAN2A1(7), MGAT1(1), MGAT4A(1), MGAT5(2), RPN2(1), STT3B(4)	7639432	50	24	50	15	17	15	12	0	6	0	0.10	0.28
231	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(1), CASP8(5), CFLAR(1)	689576	7	6	7	0	0	4	2	0	1	0	0.11	0.28
232	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C9(5)	368196	5	3	5	0	1	1	2	0	1	0	0.11	0.29
233	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	FOSB(1), GRIA2(6), PPP1R1B(1)	646316	8	7	8	3	3	0	4	0	1	0	0.11	0.29
234	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(2), ADH1C(1), ADH4(2), ADH6(2), ADH7(1), ADHFE1(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH7A1(2)	2452602	23	14	23	7	6	9	6	0	2	0	0.11	0.30
235	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(3), FARSB(2), GOT1(2), PAH(1), TAT(3), YARS(1), YARS2(2)	1587016	14	9	14	5	3	8	1	0	2	0	0.11	0.30
236	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(5), AR(3), ESR1(3), ESRRA(1), HNF4A(4), NPM1(1), NR0B1(1), NR1D2(3), NR1H3(2), NR1I2(1), NR1I3(2), NR2C2(1), NR2E1(1), NR2F1(2), NR2F2(1), NR2F6(1), NR3C1(1), NR4A1(2), NR4A2(5), PPARA(1), PPARD(1), PPARG(1), RARB(4), RARG(3), ROR1(4), RORA(1), RXRB(1), RXRG(2), THRB(1), VDR(1)	7445558	60	27	60	20	21	19	14	1	5	0	0.11	0.30
237	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(2), CHAT(1), DBH(2), GAD1(2), GAD2(2), HDC(5), MAOA(3), PAH(1), SLC18A3(1), TPH1(2)	2574880	21	16	21	17	6	9	4	0	2	0	0.11	0.30
238	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(1), HADH(1), HADHA(1), HSD17B10(1), HSD17B4(1), NTAN1(1), SIRT1(2), SIRT2(2), SIRT5(2), VNN2(2)	2146370	14	11	14	5	3	3	4	0	4	0	0.12	0.30
239	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(1), JAK1(1), JAK2(4), PTPRU(6), REG1A(2), STAT1(1)	2109774	15	10	15	3	9	2	2	0	1	1	0.12	0.30
240	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1B(2), ADH1C(1), ADH4(2), ADH6(2), ADH7(1), ADHFE1(3), AGPAT1(1), AGPAT4(4), AKR1B1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), DGKA(1), DGKB(2), DGKD(8), DGKE(2), DGKG(2), DGKH(7), DGKZ(1), GK(1), GLA(1), LCT(11), LIPC(1), LIPF(2), LPL(2), PNLIP(3), PNLIPRP1(1), PNLIPRP2(1)	8698548	77	30	77	19	30	24	16	0	7	0	0.12	0.31
241	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(2), HLA-DRA(3), HLA-DRB1(1), IL3(1)	474628	7	5	7	2	3	4	0	0	0	0	0.12	0.31
242	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(1), ARSD(1), CARM1(1), CYP11B1(4), CYP19A1(6), HSD17B2(1), HSD17B3(1), HSD3B1(1), HSD3B2(1), LCMT1(2), METTL2B(1), METTL6(3), PRMT3(1), PRMT7(2), PRMT8(2), SRD5A1(1), SRD5A2(1), STS(1), SULT1E1(1), SULT2A1(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(4), UGT2B28(1), UGT2B4(2), UGT2B7(2), WBSCR22(1)	8733978	52	27	52	14	12	20	10	2	8	0	0.12	0.31
243	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(5), ADCY2(8), ADCY3(2), ADCY4(2), ADCY7(2), ADCY8(3), ADCY9(2), ADORA2A(2), ADORA2B(1), ADRA1A(1), ADRA1B(2), ADRB1(1), AGTR1(3), ATP2A2(3), ATP2A3(1), ATP2B1(2), ATP2B2(7), ATP2B3(2), ATP2B4(3), AVPR1A(1), BDKRB2(1), CACNA1A(9), CACNA1B(4), CACNA1C(2), CACNA1D(3), CACNA1E(6), CACNA1F(5), CACNA1I(2), CACNA1S(7), CAMK2D(2), CAMK4(1), CCKAR(1), CCKBR(4), CD38(2), CHRM1(1), CHRM2(3), CHRM5(2), CHRNA7(1), CYSLTR1(2), CYSLTR2(3), EDNRA(1), EDNRB(5), EGFR(5), ERBB2(4), ERBB3(6), ERBB4(7), GNA11(1), GNA14(3), GNA15(1), GNAL(2), GNAQ(1), GNAS(2), GRIN1(1), GRIN2A(9), GRIN2C(2), GRIN2D(2), GRM1(5), GRM5(4), GRPR(1), HRH2(1), HTR2A(1), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(4), HTR7(1), ITPR1(8), ITPR2(6), ITPR3(7), MYLK(5), MYLK2(2), NOS1(6), OXTR(1), P2RX1(1), P2RX2(1), P2RX3(1), P2RX4(1), P2RX7(1), PDE1A(2), PDE1B(2), PDE1C(5), PDGFRA(4), PDGFRB(2), PHKA1(5), PHKA2(3), PHKB(2), PHKG2(2), PLCB1(1), PLCB3(3), PLCB4(2), PLCD1(4), PLCE1(2), PLCG1(1), PLCG2(4), PLCZ1(1), PLN(1), PPID(1), PPP3CA(2), PPP3CB(2), PPP3CC(3), PRKACA(1), PRKACG(1), PRKCA(3), PRKCG(5), PTGER3(1), PTGFR(3), PTK2B(1), RYR1(11), RYR2(11), RYR3(11), SLC8A1(4), SLC8A2(2), SLC8A3(6), SPHK1(1), TACR1(1), TACR3(3), TRHR(3), TRPC1(2)	50007948	351	85	347	141	139	122	60	3	25	2	0.12	0.32
244	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(2), AGTR1(3), ATF2(1), EGFR(5), GNAQ(1), GRB2(2), MAP2K1(2), MAP2K2(1), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(6), MEF2A(1), MEF2C(2), PAK1(1), PRKCA(3), PTK2(1), PTK2B(1), RAF1(4), SHC1(1), SOS1(3), SRC(3)	6244214	48	21	48	9	13	17	9	1	8	0	0.13	0.32
245	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(2), GNAQ(1), GNAS(2), GNGT1(1), LIMK1(2), MAP2K1(2), MAPK3(1), PIK3C2G(2), PLCB1(1), PPP1R12B(4), PRKCA(3), PTK2(1), RAF1(4), ROCK2(4)	4649560	30	17	30	7	9	10	3	1	7	0	0.13	0.32
246	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACAA2(1), ACADL(2), ACADM(4), ALDH1A1(1), ALDH1A2(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH6A1(2), AOX1(3), ECHS1(1), HADHA(1), HADHB(1), HMGCL(1), MCCC1(4), MCCC2(2), MCEE(1), MUT(2), PCCA(7), PCCB(3), SDS(1)	6617364	50	24	50	15	20	16	5	0	9	0	0.13	0.32
247	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ACADL(2), ACADM(4), ALDH1A1(1), ALDH1A2(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), AOC2(1), AOC3(1), CNDP1(1), DPYD(9), DPYS(1), ECHS1(1), GAD1(2), GAD2(2), HADHA(1), SDS(1), UPB1(2)	5272030	42	23	42	18	17	14	4	0	7	0	0.13	0.32
248	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(1), ADCY4(2), ADCY8(3), CACNA1A(9), CACNA1B(4), GNAS(2), GNAT3(1), GNB3(2), GNG3(1), GRM4(2), ITPR3(7), KCNB1(4), PDE1A(2), PRKACA(1), PRKACG(1), SCNN1A(2), SCNN1B(2), SCNN1G(3), TAS1R1(2), TAS1R2(4), TAS2R1(1), TAS2R10(3), TAS2R13(1), TAS2R14(1), TAS2R16(2), TAS2R38(1), TAS2R39(1), TAS2R4(1), TAS2R46(1), TAS2R5(2), TAS2R50(2), TAS2R60(1), TAS2R7(1), TAS2R8(1), TAS2R9(2)	10311762	76	33	75	31	33	24	15	0	4	0	0.13	0.32
249	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRA(1), BLVRB(2), CP(3), CPOX(1), EPRS(4), FECH(1), GUSB(1), HCCS(3), HMOX2(2), PPOX(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(2), UROD(1)	4743490	27	18	27	7	6	14	4	0	3	0	0.13	0.32
250	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(1), PRKCA(3), PTK2B(1)	1227184	6	6	6	3	2	2	1	0	1	0	0.13	0.32
251	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	FOS(1), GRB2(2), IL6(2), IL6R(1), IL6ST(1), JAK1(1), JAK2(4), JAK3(4), MAP2K1(2), MAPK3(1), PTPN11(4), RAF1(4), SHC1(1), SOS1(3), STAT3(1)	4310410	32	17	32	4	10	12	5	0	4	1	0.13	0.32
252	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(5), ADCY2(8), ADCY3(2), ADCY4(2), ADCY5(6), ADCY7(2), ADCY8(3), ADCY9(2), ADRA1A(1), ADRA1B(2), ADRB1(1), ANXA6(1), ATP1A4(3), ATP1B1(1), ATP1B2(2), ATP2A2(3), ATP2A3(1), ATP2B1(2), ATP2B2(7), ATP2B3(2), CACNA1A(9), CACNA1B(4), CACNA1C(2), CACNA1D(3), CACNA1E(6), CACNA1S(7), CACNB3(1), CALR(1), CAMK1(2), CAMK2D(2), CAMK4(1), CASQ1(1), CASQ2(3), CHRM1(1), CHRM2(3), CHRM4(1), CHRM5(2), GJA1(4), GJA4(1), GJA5(2), GJB3(2), GNA11(1), GNAO1(2), GNAQ(1), GNB3(2), GNB4(1), GNG3(1), GNG4(1), GNGT1(1), GRK4(1), GRK5(1), ITPR1(8), ITPR2(6), ITPR3(7), KCNB1(4), KCNJ5(1), MIB1(3), MYCBP(1), NME7(2), PLCB3(3), PLN(1), PRKACA(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCQ(2), PRKD1(5), RGS1(1), RGS17(2), RGS2(3), RGS20(1), RGS3(3), RGS4(2), RGS5(1), RGS7(4), RGS9(3), RYR1(11), RYR2(11), RYR3(11), SLC8A1(4), SLC8A3(6), USP5(2), YWHAH(1)	35372852	253	66	253	110	100	101	31	0	20	1	0.13	0.32
253	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(1), DYRK1B(3), GLI2(2), GLI3(6), GSK3B(2), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), SMO(1), SUFU(2)	2866026	24	15	24	8	6	11	4	0	3	0	0.13	0.32
254	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(4), AMY2A(2), AMY2B(1), ASCC3(8), DDX18(1), DDX19A(1), DDX23(1), DDX4(1), DDX50(1), DDX52(1), DDX55(2), DDX56(2), DHX58(1), ENPP3(2), EP400(7), ERCC2(2), ERCC3(3), G6PC(1), G6PC2(1), GANC(1), GBE1(1), GCK(1), GPI(1), GUSB(1), GYS1(2), GYS2(4), HK1(2), HK3(1), IFIH1(2), MGAM(4), MOV10L1(7), PGM1(3), PGM3(2), PYGB(1), PYGM(3), RAD54B(3), RAD54L(1), SETX(10), SI(4), SKIV2L2(2), SMARCA2(2), SMARCA5(4), UGDH(1), UGP2(3), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(4), UGT2B28(1), UGT2B4(2), UGT2B7(2), UXS1(1)	22440112	126	38	126	36	31	41	33	0	21	0	0.13	0.33
255	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(4), DAXX(1), EGFR(5), ETS1(1), ETS2(1), FOS(1), IKBKB(2), MAP2K1(2), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K5(3), MAPK13(1), MAPK3(1), MAPK8(6), NFKB1(4), PPP2CA(1), PRKCA(3), PRKCE(2), PRKCG(5), PRKCH(1), PRKCQ(2), RAF1(4), SP1(1)	8899820	61	29	61	19	23	19	14	2	3	0	0.14	0.33
256	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(1), MMP2(3), MMP9(6), RECK(3), TIMP1(1), TIMP2(1), TIMP3(1)	1382340	16	10	16	4	9	3	3	0	1	0	0.14	0.33
257	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	AKT1(1), AKT2(2), AKT3(1), ARHGEF11(6), CDC42(1), DLG4(1), LPA(1), MAP2K4(2), MAP3K1(2), MAP3K5(3), MAPK8(6), NFKB1(4), NFKB2(2), PDK1(2), PHKA2(3), PI3(1), PIK3CB(1), PLD1(6), PLD2(1), PLD3(1), PTK2(1), RDX(1), ROCK1(8), ROCK2(4), SERPINA4(5)	8819000	66	24	66	19	22	21	11	2	10	0	0.14	0.33
258	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(5), ACACB(5), ACADM(4), ACSS1(1), ACSS2(1), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH6A1(2), ALDH7A1(2), ECHS1(1), HADHA(1), HIBCH(1), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHB(2), LDHC(1), MCEE(1), MUT(2), PCCA(7), PCCB(3), SUCLA2(3), SUCLG1(1)	7258738	58	24	58	16	15	23	7	0	13	0	0.14	0.33
259	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(1), DPYD(9), DPYS(1), ENPP3(2), PANK3(2), PPCS(1), UPB1(2)	2455336	18	11	18	7	4	9	3	0	2	0	0.14	0.33
260	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(3), FOS(1), MAP2K1(2), MAPK3(1), NFKB1(4), PLCB1(1), PRKCA(3), RAF1(4)	2762048	19	10	19	7	10	4	2	1	2	0	0.14	0.34
261	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT1(1), AKT2(2), AKT3(1), BTK(2), DAPP1(1), GRB2(2), GSK3B(2), IARS(3), INPP5D(2), PDK1(2), PIK3CA(7), PPP1R13B(1), PTEN(4), RPS6KA2(4), RPS6KA3(2), SHC1(1), SOS1(3), SOS2(6), TEC(2), YWHAH(1)	6578656	49	23	49	14	11	20	13	0	5	0	0.14	0.34
262	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(5), ADCY2(8), ADCY3(2), ADCY4(2), ADCY5(6), ADCY7(2), ADCY8(3), ADSL(2), ADSS(1), AK2(1), AK5(2), ALLC(2), AMPD1(6), AMPD2(3), AMPD3(1), ATIC(1), ATP1B1(1), ATP5A1(3), ATP5B(3), ATP5C1(2), DCK(1), ENPP3(2), ENTPD1(1), GART(1), GUCY1A2(6), GUCY1A3(5), GUCY1B3(2), GUCY2C(3), GUCY2D(6), GUCY2F(6), IMPDH1(2), IMPDH2(3), NPR1(2), NPR2(2), NT5E(1), PAICS(1), PAPSS1(1), PAPSS2(2), PDE1A(2), PDE4A(1), PDE4B(3), PDE4D(1), PDE5A(3), PDE6B(4), PDE6C(3), PDE7B(1), PDE9A(2), POLB(3), POLD1(2), POLD2(1), POLE(10), POLG(2), POLL(1), POLQ(5), POLR1B(5), POLR2A(1), POLR2B(3), POLR2D(1), POLR2K(1), PPAT(5), PRPS1(1), PRPS2(1), PRUNE(1), RRM1(2)	23530700	169	49	168	60	61	53	35	1	19	0	0.14	0.34
263	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(3), DLL1(3), FURIN(1)	1353676	7	5	7	1	2	1	0	0	4	0	0.14	0.34
264	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(1), ERCC3(3), GTF2E1(2), GTF2F2(1), GTF2H1(3), MNAT1(1), POLR1A(3), POLR1B(5), POLR2A(1), POLR2B(3), POLR2K(1), POLR3B(9), POLR3E(4), POLR3K(1), TAF5(3), TAF6(2), TAF7(1), TAF9(1)	6401828	45	22	45	10	16	15	8	0	6	0	0.14	0.34
265	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	20	B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(2), B4GALT3(3), FUT1(3), FUT3(2), FUT9(2), GCNT2(4), ST3GAL6(4)	2616528	23	15	23	5	12	4	4	1	2	0	0.15	0.34
266	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(1), GTF2E1(2), GTF2F1(3), GTF2F2(1), GTF2H1(3), GTF2IRD1(2), TAF1(6), TAF1L(9), TAF2(5), TAF4(1), TAF4B(2), TAF5(3), TAF5L(2), TAF6(2), TAF7(1), TAF7L(1), TAF9(1), TAF9B(1)	6539876	46	22	46	11	11	18	9	0	8	0	0.15	0.34
267	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1), B3GNT7(2), B4GALT1(2), B4GALT3(3), CHST1(1), CHST4(3), FUT8(2), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1)	2072768	19	12	19	4	7	2	7	1	2	0	0.15	0.35
268	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT2(2), GALNT6(1), GALNT7(1), GALNT8(1), GCNT1(2), ST3GAL2(1), ST3GAL4(1), WBSCR17(8)	2629398	17	11	17	7	6	5	5	0	1	0	0.15	0.35
269	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(2), BIRC2(2), BIRC3(5), CASP10(1), CASP3(1), CASP7(1), CASP8(5), CASP9(1), DFFA(2), DFFB(1), GZMB(2), SCAP(1)	3234720	24	13	24	7	4	10	4	0	6	0	0.15	0.35
270	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CDKN1A(1), GNAQ(1), NFATC1(1), NFATC2(3), NFATC3(1), NFATC4(2), PLCG1(1), PPP3CA(2), PPP3CB(2), PPP3CC(3), PRKCA(3), SP1(1), SP3(2)	3616518	23	16	23	6	10	6	2	0	5	0	0.16	0.36
271	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA1(1), ACAA2(1), ACADM(4), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH6A1(2), ALDH7A1(2), AOX1(3), DLD(1), ECHS1(1), HADH(1), HADHA(1), HADHB(1), HIBCH(1), HMGCL(1), HMGCS2(1), HSD17B10(1), HSD17B4(1), MCCC1(4), MCCC2(2), MCEE(1), MUT(2), PCCA(7), PCCB(3)	7934256	52	25	52	16	19	17	6	0	10	0	0.16	0.36
272	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(4), GZMB(2), HLA-A(2), ITGAL(4), ITGB2(2)	1511848	14	8	14	6	3	4	4	0	2	1	0.16	0.37
273	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(3), IDH1(1), IDH2(1), SUCLA2(3)	1640084	8	7	8	6	1	5	0	0	2	0	0.16	0.37
274	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(3), CREBBP(8), DFFA(2), DFFB(1), GZMA(2), GZMB(2)	1965004	18	10	18	5	7	5	2	0	4	0	0.17	0.37
275	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH3B1(1), ALDH3B2(1), ALDH7A1(2), AOC2(1), AOC3(1), ASPA(2), CARM1(1), CNDP1(1), HAL(1), HARS2(3), HDC(5), LCMT1(2), MAOA(3), MAOB(1), METTL2B(1), METTL6(3), PRMT3(1), PRMT7(2), PRMT8(2), PRPS1(1), PRPS2(1), UROC1(3), WBSCR22(1)	7197958	49	27	48	23	18	18	7	2	4	0	0.17	0.39
276	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(2), GNGT1(1), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), PRKCA(3)	1716020	13	10	13	1	4	6	2	0	1	0	0.17	0.39
277	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(8), EP300(8), LPL(2), NCOA1(3), NCOA2(3), PPARG(1)	3374258	25	15	25	6	8	7	6	1	3	0	0.18	0.39
278	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), PLCD1(4), PRKCA(3), TGM2(2)	916306	11	8	11	2	4	7	0	0	0	0	0.18	0.39
279	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(4), ECHS1(1), HADHA(1)	982518	8	5	8	4	2	2	0	0	4	0	0.18	0.39
280	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT1(1), AGPAT4(4), AGPS(1), CDS1(2), CDS2(2), CHAT(1), CHKA(2), CLC(1), CPT1B(1), DGKA(1), DGKB(2), DGKD(8), DGKE(2), DGKG(2), DGKH(7), DGKZ(1), ETNK1(1), GNPAT(1), GPD2(1), LCAT(1), PAFAH2(1), PCYT1A(2), PCYT1B(1), PEMT(1), PISD(2), PLA2G4A(4), PLA2G6(2), PLCG1(1), PLCG2(4)	9012318	62	28	62	25	27	11	15	0	9	0	0.18	0.40
281	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK2(4), JAK3(4), MAPK3(1), STAT3(1)	2151290	11	9	11	2	1	5	1	0	3	1	0.18	0.40
282	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ACADM(4), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH7A1(2), AOC2(1), AOC3(1), CNDP1(1), DPYD(9), DPYS(1), ECHS1(1), GAD1(2), GAD2(2), HADHA(1), HIBCH(1), UPB1(2)	4890732	38	21	38	17	12	15	4	0	7	0	0.19	0.41
283	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(1), ACMSD(1), AFMID(1), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH7A1(2), AOC2(1), AOC3(1), AOX1(3), CARM1(1), CAT(1), CYP1A1(2), CYP1A2(2), CYP1B1(1), ECHS1(1), GCDH(3), HADH(1), HADHA(1), HSD17B10(1), HSD17B4(1), INMT(2), KMO(2), KYNU(2), LCMT1(2), LNX1(5), MAOA(3), MAOB(1), METTL2B(1), METTL6(3), NFX1(6), OGDH(2), OGDHL(5), PRMT3(1), PRMT7(2), PRMT8(2), TDO2(2), TPH1(2), TPH2(4), WARS(1), WARS2(2), WBSCR22(1)	10946110	85	33	85	25	26	31	16	2	10	0	0.19	0.41
284	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(1), ADRA1B(2), ADRA2A(1), ADRB1(1), CHRM1(1), CHRM2(3), CHRM4(1), CHRM5(2), DRD2(4), DRD3(2), DRD5(4), HRH2(1), HTR1A(2), HTR1B(2), HTR1D(1), HTR1E(4), HTR2A(1), HTR2B(1), HTR2C(2), HTR4(1), HTR5A(4), HTR7(1)	4496280	42	21	42	20	19	14	4	1	4	0	0.19	0.41
285	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	COASY(1), DPYD(9), DPYS(1), ENPP3(2), PANK3(2), PPCS(1), UPB1(2), VNN1(3)	3091356	21	13	21	10	6	10	3	0	2	0	0.19	0.41
286	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(10), MAP2(10), PPP2CA(1), PRKACG(1), PRKAR2B(1), PRKCE(2)	3344110	25	15	24	10	5	12	6	0	2	0	0.19	0.41
287	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(4), CD19(1), CD1A(2), CD1B(1), CD1C(1), CD1D(1), CD1E(1), CD22(4), CD33(1), CD38(2), CD44(2), CD5(3), CD55(2), CR1(3), CR2(3), CSF1(1), CSF3R(5), DNTT(3), FCER2(1), FLT3(2), GP5(2), HLA-DRA(3), HLA-DRB1(1), HLA-DRB5(1), IL1B(1), IL1R1(1), IL1R2(5), IL3(1), IL4(1), IL5RA(2), IL6(2), IL6R(1), IL7(1), IL7R(2), ITGA1(1), ITGA2(2), ITGA2B(3), ITGA4(5), ITGA5(2), ITGA6(2), ITGAM(3), ITGB3(2), KIT(2), KITLG(1), MME(7), MS4A1(1), TFRC(1), THPO(1), TPO(4)	14797516	104	35	104	46	31	49	15	3	6	0	0.19	0.41
288	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(1), HLCS(2), SPCS1(1), SPCS3(1)	569752	5	4	5	1	2	1	1	0	1	0	0.19	0.41
289	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	JAK1(1), PTPRU(6), REG1A(2), STAT1(1), STAT2(4)	2294188	14	11	14	4	11	1	1	0	1	0	0.19	0.41
290	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS1(1), DHRS2(1), DHRS3(1), ESCO1(6), ESCO2(1), MYST3(10), MYST4(7), SH3GLB1(1)	2905312	28	13	28	8	10	7	8	1	2	0	0.20	0.42
291	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(1), IMPA2(1), INPP4A(1), INPP4B(2), INPPL1(3), ITGB1BP3(1), MINPP1(1), OCRL(6), PI4KA(9), PI4KB(1), PIK3C3(5), PIK3CA(7), PIK3CB(1), PIK3CD(2), PIK3CG(5), PIP4K2C(1), PIP5K1B(1), PIP5K1C(3), PLCB1(1), PLCB3(3), PLCB4(2), PLCD1(4), PLCE1(2), PLCG1(1), PLCG2(4), PLCZ1(1), PTEN(4), SYNJ1(4), SYNJ2(1)	13523264	78	32	78	25	21	30	14	1	12	0	0.20	0.42
292	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(2), ACTN2(5), ACTN3(1), BCR(2), CAV1(1), CSK(2), FYN(1), GRB2(2), ITGA1(1), MAP2K1(2), MAP2K2(1), MAPK3(1), MAPK8(6), PPP1R12B(4), PTK2(1), RAF1(4), RAP1A(1), ROCK1(8), SHC1(1), SOS1(3), SRC(3), TLN1(3), VCL(2), ZYX(1)	8550694	59	27	59	14	20	21	11	1	6	0	0.20	0.42
293	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), ADRBK2(2), CAMK2D(2), CLCA1(4), CLCA2(5), CLCA4(1), CNGA3(2), CNGA4(2), GNAL(2), GUCA1A(1), GUCA1B(1), GUCA1C(1), PDC(1), PDE1C(5), PRKACA(1), PRKACG(1), PRKG1(8), PRKG2(3)	5665708	44	21	44	17	10	21	9	0	4	0	0.20	0.42
294	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(3), GPR161(2), GPR171(1), GPR18(2), GPR34(2), GPR39(1), GPR45(4), GPR65(1), GPR75(1)	1808444	19	11	19	6	8	4	4	0	3	0	0.20	0.42
295	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12B(1), ALOX15B(1), ALOX5(1), CYP2C18(2), CYP2C8(2), CYP2C9(5), CYP2E1(3), CYP2J2(3), CYP4A11(2), CYP4A22(1), CYP4F2(2), CYP4F3(1), GPX3(2), GPX5(2), GPX6(1), PLA2G4A(4), PLA2G6(2), PTGIS(2), PTGS1(4), PTGS2(1), TBXAS1(3)	7150870	47	25	47	13	19	13	11	0	4	0	0.20	0.43
296	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(2), BLNK(1), FOS(1), GRB2(2), MAP2K1(2), MAP3K1(2), MAPK3(1), MAPK8IP3(1), PAPPA(10), RPS6KA3(2), SHC1(1), SOS1(3), SYK(3), VAV1(7), VAV2(3), VAV3(3)	5691888	45	21	45	6	12	21	6	0	6	0	0.20	0.43
297	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(4), EGFR(5), GRB2(2), MAP2K1(2), MAPK3(1), RAF1(4), RASA1(5), SHC1(1), SOS1(3), SPRY1(3), SPRY4(1), SRC(3)	4490396	34	15	34	11	12	12	7	0	3	0	0.21	0.43
298	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(3), CCND2(1), CCND3(1), CCNE1(1), CCNH(1), CDC25A(1), CDK4(1), CDKN1A(1), CDKN1B(2), RB1(3), RBL1(4), TFDP1(1)	2908222	20	13	20	5	6	4	4	0	6	0	0.21	0.43
299	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(3), POLA2(2), POLB(3), POLD1(2), POLD2(1), POLD3(1), POLE(10), POLE2(1), POLG(2), POLH(3), POLI(3), POLK(1), POLL(1), POLM(1), POLQ(5), PRIM2(3), REV1(3), REV3L(9), RFC5(1)	7685812	55	21	53	13	15	19	8	0	12	1	0.21	0.43
300	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(4), CDA(1), CTPS(1), DCK(1), DCTD(2), DHODH(1), DPYD(9), DPYS(1), DTYMK(1), ENTPD1(1), NT5E(1), POLB(3), POLD1(2), POLD2(1), POLE(10), POLG(2), POLL(1), POLQ(5), POLR1B(5), POLR2A(1), POLR2B(3), POLR2D(1), POLR2K(1), RRM1(2), TK2(1), TXNRD1(1), TYMS(2), UCK2(1), UMPS(1), UPB1(2)	10487466	68	33	67	18	23	23	14	0	8	0	0.21	0.43
301	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE2(3), AGT(2), AGTR1(3), AGTR2(1), ANPEP(4), CPA3(2), CTSG(2), ENPEP(5), LNPEP(4), MAS1(1), MME(7), NLN(2), REN(2)	3819944	38	18	38	9	10	16	9	0	3	0	0.22	0.44
302	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS1(1), ALAS2(3), BLVRA(1), BLVRB(2), COX15(2), CP(3), CPOX(1), EPRS(4), FECH(1), FTMT(2), GUSB(1), HCCS(3), HMOX2(2), MMAB(1), PPOX(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(4), UGT2B28(1), UGT2B4(2), UGT2B7(2), UROD(1)	7312754	47	21	47	11	12	24	7	0	4	0	0.22	0.44
303	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(3), AZIN1(1), BTG1(1), CBX3(2), CLOCK(3), CRY1(3), DNAJA1(1), ETV6(2), GFRA1(6), GSTM3(1), HSPA8(3), MYF6(1), NCKAP1(3), NCOA4(1), NR1D2(3), PER2(1), PPP1R3C(2), PPP2CB(2), PSMA4(1), TOB1(2), TUBB3(1), UGP2(3), ZFR(5)	6630052	51	19	50	10	7	18	15	1	9	1	0.22	0.45
304	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	SUCLA2(3)	392246	3	3	3	1	0	2	0	0	1	0	0.23	0.46
305	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL10(1), IL12A(1), IL12B(1), IL15(1), IL16(5), IL2(2), IL3(1), IL4(1), IL6(2), IL8(1), IL9(2)	1749872	18	8	18	6	5	10	2	0	1	0	0.23	0.47
306	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMA7(1), PSMB3(1), PSMB5(2), PSMB6(1), PSMD1(5), PSMD12(2), PSMD13(1), PSMD2(1), PSMD6(2)	2944258	20	10	20	11	8	6	2	1	3	0	0.23	0.47
307	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(2), CAMK1G(3), GNA15(1), GNGT1(1), MAP2K1(2), MAP2K2(1), MAP2K3(4), MAP2K6(1), MAP3K1(2), MAPK3(1), NCF2(1), NFATC1(1), NFATC2(3), NFATC3(1), NFATC4(2), NFKB1(4), PAK1(1), PIK3C2G(2), PLCB1(1), PPP3CA(2), PPP3CB(2), PPP3CC(3), RAF1(4)	6974960	45	20	45	18	16	14	7	2	6	0	0.24	0.48
308	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(2), C5(5), C6(6), C7(3), IL6(2), IL8(1), ITGA4(5), ITGAL(4), ITGB2(2), SELP(2), SELPLG(1), VCAM1(2)	4531846	35	16	35	14	13	12	4	0	6	0	0.24	0.48
309	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMA7(1), PSMB3(1), PSMB5(2), PSMB6(1), PSMD14(1), RPN2(1), UBE3A(5)	2404936	16	9	16	6	5	6	3	0	2	0	0.24	0.48
310	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(3), LARS(1), LARS2(1), PDHA1(1), PDHA2(4)	1835808	10	8	10	4	3	2	4	0	1	0	0.24	0.48
311	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT1(2), B4GALT3(3), FUT8(2), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1)	1401722	12	9	12	3	4	2	5	0	1	0	0.24	0.48
312	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD80(1), HLA-DRA(3), HLA-DRB1(1), IL10(1), IL2(2), IL4(1)	663756	10	5	10	1	3	7	0	0	0	0	0.25	0.49
313	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1), CHRNA1(4)	595886	5	5	5	2	2	2	1	0	0	0	0.25	0.49
314	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CSNK1D(2), DRD2(4), GRM1(5), PLCB1(1), PPP1R1B(1), PPP2CA(1), PPP3CA(2), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1)	2894496	23	14	23	10	11	4	4	1	3	0	0.25	0.50
315	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(4), AGT(2), AGTR2(1), EDNRA(1), EDNRB(5), EGFR(5), FOS(1), NFKB1(4), PLCG1(1), PRKCA(3)	3732178	27	17	27	9	10	9	7	0	1	0	0.26	0.51
316	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(3), FUT3(2), ST3GAL3(3)	826864	8	6	8	1	5	1	2	0	0	0	0.26	0.51
317	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(5), CASP8(5)	1441642	11	8	11	3	2	6	1	0	2	0	0.26	0.51
318	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), CHPT1(1), LCMT1(2), METTL2B(1), METTL6(3), PCYT1A(2), PCYT1B(1), PRMT3(1), PRMT7(2), PRMT8(2), WBSCR22(1)	2564604	17	12	17	6	6	4	3	2	2	0	0.26	0.51
319	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(5), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(2), ADIPOQ(2), ADIPOR1(1), ADIPOR2(2), AKT1(1), AKT2(2), AKT3(1), CAMKK1(1), CHUK(4), CPT1A(3), CPT1B(1), CPT2(2), G6PC(1), G6PC2(1), IKBKB(2), IRS1(4), IRS4(8), JAK1(1), JAK2(4), JAK3(4), LEPR(5), MAPK10(6), MAPK8(6), MAPK9(2), NFKB1(4), NFKB2(2), NPY(2), PCK1(3), PCK2(2), PPARA(1), PRKAA1(1), PRKAA2(4), PRKAB1(1), PRKAG2(2), PRKAG3(3), PRKCQ(2), PTPN11(4), RXRB(1), RXRG(2), SLC2A1(1), SLC2A4(2), STAT3(1)	14733292	112	36	112	36	31	42	21	3	14	1	0.27	0.51
320	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACYP1(2), ECHS1(1), GCDH(3), HADHA(1), SDS(1)	1434008	8	6	8	2	3	1	1	0	3	0	0.27	0.52
321	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(5), COL4A2(1), COL4A3(1), COL4A4(2), COL4A5(5), COL4A6(5), SLC23A1(2), SLC23A2(4), SLC2A1(1)	4773232	26	17	26	9	9	7	5	1	4	0	0.27	0.53
322	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	CASP8(5), MAP2K1(2), MAP2K4(2), MAP3K1(2), MAPK3(1), MAPK8(6), NFKB1(4), NSMAF(2), RAF1(4)	3736804	28	16	28	9	10	10	4	1	3	0	0.28	0.53
323	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CBS(2), CTH(1), MUT(2)	875660	6	5	6	0	1	3	0	0	2	0	0.28	0.54
324	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), PARK2(3), SNCAIP(2), UBE2E2(1)	1150370	9	7	9	3	4	4	1	0	0	0	0.28	0.54
325	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN1(1), GRIN2A(9), GRIN2B(3), GRIN2C(2), GRIN2D(2), NOS1(6), PPP3CA(2), PPP3CB(2), PPP3CC(3), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), PRKCA(3)	4631792	41	18	41	11	18	12	6	0	4	1	0.28	0.54
326	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	CHAD(2), COL11A1(8), COL11A2(3), COL17A1(4), COL1A1(2), COL1A2(6), COL2A1(2), COL3A1(7), COL4A1(5), COL4A2(1), COL4A4(2), COL4A6(5), COL5A1(7), COL5A2(4), COL5A3(6), COL6A2(1), COL6A3(20), COL6A6(5), DSC1(2), DSC2(1), DSC3(3), DSG1(3), DSG4(6), FN1(6), GJA1(4), GJA10(5), GJA4(1), GJA5(2), GJA8(1), GJA9(3), GJB3(2), GJB7(1), GJC3(1), GJD2(1), IBSP(1), INA(1), ITGA6(2), ITGB4(1), KRT1(1), KRT12(1), KRT13(2), KRT14(2), KRT15(1), KRT20(1), KRT23(1), KRT24(2), KRT25(1), KRT27(1), KRT28(1), KRT3(1), KRT32(1), KRT33B(2), KRT35(2), KRT36(1), KRT37(5), KRT38(2), KRT5(1), KRT6A(2), KRT6B(1), KRT7(3), KRT72(2), KRT73(2), KRT74(2), KRT75(3), KRT76(1), KRT78(2), KRT79(2), KRT81(1), KRT82(2), KRT84(6), KRT85(3), KRT9(2), LAMA1(7), LAMA2(10), LAMA3(8), LAMA4(6), LAMB1(2), LAMB2(3), LAMB3(1), LAMB4(6), LAMC1(6), LAMC2(4), LAMC3(4), LMNB1(3), NES(3), PRPH(1), RELN(13), THBS1(3), THBS2(8), THBS3(2), THBS4(1), TNC(7), TNN(4), TNR(4), TNXB(4), VIM(3), VTN(3), VWF(7)	44308510	323	73	322	136	126	111	49	4	32	1	0.28	0.54
327	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1), IL8(1)	308914	2	2	2	0	0	1	0	0	1	0	0.29	0.54
328	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(1), CYP1A2(2), CYP2C18(2), CYP2C8(2), CYP2C9(5), CYP2E1(3), CYP2J2(3), CYP3A43(2), CYP3A7(3), PLA2G4A(4), PLA2G6(2), RDH11(1), RDH12(2)	4384546	32	15	32	9	13	8	7	0	4	0	0.29	0.54
329	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(1), ADH1B(2), ADH1C(1), ADH4(2), ADH6(2), ADH7(1), ADHFE1(3), AKR1C2(2), AKR1C3(2), AKR1C4(1), ALDH1A3(4), ALDH3B1(1), ALDH3B2(1), CYP1A1(2), CYP1A2(2), CYP1B1(1), CYP2C18(2), CYP2C8(2), CYP2C9(5), CYP2E1(3), CYP2F1(1), CYP2S1(1), CYP3A43(2), CYP3A7(3), EPHX1(2), GSTA3(1), GSTA5(1), GSTM3(1), GSTM4(1), GSTO2(1), GSTZ1(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(4), UGT2B28(1), UGT2B4(2), UGT2B7(2)	10098512	72	27	72	18	18	25	20	0	9	0	0.29	0.54
330	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(4), EGFR(5), TF(6), TFRC(1)	2328032	16	10	16	4	6	6	3	0	1	0	0.29	0.54
331	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(5), POLR1C(2), POLR1D(2), POLR2A(1), POLR2B(3), POLR2D(1), POLR2K(1), POLR3A(6), POLR3B(9), POLR3GL(1), POLR3K(1)	4245294	35	17	35	3	13	11	8	0	3	0	0.29	0.55
332	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GABBR1(4), GPRC5B(1), GPRC5C(1), GRM1(5), GRM2(3), GRM3(3), GRM4(2), GRM5(4), GRM7(5), GRM8(2)	3572280	32	16	32	20	12	12	5	0	3	0	0.30	0.56
333	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREBBP(8), EP300(8), NCOA3(5), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1)	3743808	29	16	29	5	8	11	4	2	4	0	0.30	0.56
334	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), BLVRB(2), IL10(1), IL10RA(1), IL10RB(3), IL6(2), JAK1(1), STAT1(1), STAT3(1)	2188676	13	7	12	4	5	3	2	0	3	0	0.30	0.56
335	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH7A1(2), UGDH(1)	1543620	12	8	12	2	3	5	2	0	2	0	0.30	0.56
336	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ACAA2(1), ADH1A(1), ADH1B(2), ADH1C(1), ADH4(2), ADH6(2), ADH7(1), ADHFE1(3), AKR1C4(1), AKR1D1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), CYP27A1(1), CYP7A1(1), HADHB(1), SRD5A1(1), SRD5A2(1)	4276944	34	20	34	14	11	13	8	0	2	0	0.31	0.56
337	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(1), ALDH5A1(2), CAD(4), CPS1(7), EPRS(4), GAD1(2), GAD2(2), GFPT1(3), GLUL(2), GOT1(2), GPT2(1), GSS(1), NADSYN1(1), PPAT(5), QARS(3)	6038578	41	21	41	12	13	16	7	2	3	0	0.31	0.56
338	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(7), ATP4A(6), ATP4B(1), ATP5A1(3), ATP5B(3), ATP5C1(2), ATP5L(2), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(4), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), COX15(2), COX4I1(1), COX4I2(1), LHPP(1), NDUFA12(1), NDUFA4(1), NDUFA9(2), NDUFB6(1), NDUFB9(1), NDUFC2(1), NDUFS1(2), NDUFS2(3), NDUFS4(1), NDUFS5(2), NDUFS6(1), NDUFV3(1), PPA2(2), SDHA(1), UQCRC2(1)	10280784	70	30	70	26	25	21	17	0	7	0	0.31	0.57
339	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(3), ASPH(1), COPS5(1), EP300(8), HIF1A(3), LDHA(2), VHL(1)	2983604	19	13	19	3	5	6	5	1	2	0	0.32	0.58
340	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOB(2), ALDOC(2)	684946	6	5	6	0	3	2	1	0	0	0	0.32	0.58
341	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(3), DLD(1), DLST(1), IDH1(1), IDH2(1), IDH3A(3), PC(4), PCK1(3), SDHA(1), SUCLA2(3), SUCLG1(1)	3802792	22	14	22	12	5	11	2	0	4	0	0.32	0.58
342	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(5), COL4A2(1), COL4A3(1), COL4A4(2), COL4A5(5), COL4A6(5), F11(1), F2(2), F5(10), F8(5), FGA(6), FGB(1), FGG(2), KLKB1(5), PROS1(3), SERPINC1(1), SERPING1(2)	8221012	57	23	57	16	15	23	12	1	6	0	0.33	0.59
343	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT1(2), B4GALT3(3), DDOST(1), DPAGT1(1), FUT8(2), MAN1A1(2), MAN1B1(1), MGAT1(1), MGAT4A(1), MGAT5(2), RPN2(1)	3469172	18	14	18	9	7	4	3	0	4	0	0.33	0.60
344	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(5), ACYP1(2), AKR1B1(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), DLAT(1), DLD(1), GRHPR(1), LDHA(2), LDHB(2), LDHC(1), LDHD(1), ME1(3), ME3(3), PC(4), PCK1(3), PDHA1(1), PDHA2(4)	6696796	48	23	48	22	18	16	8	1	5	0	0.34	0.61
345	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAA2(1), ECHS1(1), HADHA(1), HADHB(1), SDS(1)	1538662	6	6	6	5	1	2	1	0	2	0	0.34	0.61
346	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(1), KLK2(3), MAP2K1(2), MAP2K2(1), MAPK3(1), NGFR(1), RAF1(4)	1464282	13	8	11	3	5	5	2	0	1	0	0.34	0.61
347	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A2(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH3B1(1), ALDH3B2(1), AOC2(1), AOC3(1), ASPA(2), CNDP1(1), HAL(1), HDC(5), MAOA(3), MAOB(1), PRPS1(1), PRPS2(1)	4480094	32	21	32	20	11	13	6	0	2	0	0.34	0.61
348	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(1), FOS(1), GRB2(2), IL3(1), JAK2(4), MAP2K1(2), MAPK3(1), RAF1(4), SHC1(1), SOS1(3), STAT5B(1)	3102182	21	11	21	4	6	7	4	0	3	1	0.35	0.61
349	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	ATF1(1), CASP2(1), CHUK(4), CRADD(1), IKBKB(2), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP4K2(1), MAPK8(6), NFKB1(4), TANK(3)	4429734	33	16	33	14	12	10	8	2	1	0	0.35	0.62
350	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CSF1(1), IL2(2), IL3(1), IL4(1), IL6(2), IL7(1), IL8(1), IL9(2)	1138680	11	6	11	4	5	5	1	0	0	0	0.35	0.62
351	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT1(3), FUT9(2), GCNT2(4)	1074248	9	6	9	3	6	2	0	0	1	0	0.35	0.62
352	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(1), BDKRB2(1), CAV1(1), CHRM1(1), CHRNA1(4), FLT1(4), FLT4(1), KDR(3), PDE3A(1), PDE3B(1), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), PRKG1(8), PRKG2(3), RYR2(11)	7409102	48	24	48	19	11	22	12	0	3	0	0.35	0.62
353	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(2), FOS(1), MAPK3(1), OPRK1(1), POLR2A(1), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1)	2327288	13	10	13	3	7	3	1	0	2	0	0.36	0.62
354	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(1), AKT2(2), AKT3(1), ASAH1(1), BRAF(10), DAG1(3), DRD2(4), EGFR(5), EPHB2(3), GRB2(2), ITPR1(8), ITPR2(6), ITPR3(7), KCNJ5(1), KCNJ9(2), PI3(1), PIK3CB(1), PLCB1(1), PLCB3(3), PLCB4(2), RAF1(4), RGS20(1), SHC1(1), SOS1(3), SOS2(6), SRC(3), STAT3(1), TERF2IP(2)	10787942	85	30	78	19	33	24	21	1	5	1	0.36	0.62
355	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(3), GRHPR(1), HAO2(1), MTHFD1(4), MTHFD1L(3)	2357424	12	10	12	6	3	7	0	1	1	0	0.36	0.62
356	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCR5(1), CXCR4(1), FOS(1), GNAQ(1), MAPK8(6), PLCG1(1), PRKCA(3), PTK2B(1)	2467340	15	9	15	5	3	6	3	1	2	0	0.36	0.62
357	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(1), DHRS1(1), DHRS2(1), DHRS3(1), LCMT1(2), METTL2B(1), METTL6(3), PRMT3(1), PRMT7(2), PRMT8(2), WBSCR22(1)	2604928	16	10	16	5	7	3	1	2	3	0	0.36	0.62
358	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(4), CKM(1), LDHA(2), LDHB(2), LDHC(1), NCL(1)	1609008	11	8	11	7	3	7	1	0	0	0	0.37	0.63
359	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(2), HLA-DRA(3), HLA-DRB1(1), IL1B(1), IL4(1), IL5RA(2), IL6(2)	911416	12	6	12	3	6	6	0	0	0	0	0.37	0.63
360	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(3), HSD3B1(1), HSD3B2(1)	1255480	5	5	5	3	2	2	0	0	1	0	0.37	0.63
361	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), ESR1(3), GREB1(5), HSPB2(1), MTA1(1), MTA3(1), TUBA8(2)	1868688	14	8	14	2	5	3	2	1	3	0	0.37	0.63
362	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(2), AGTR2(1), CAMK2D(2), F2(2), FYN(1), GNA11(1), GNAI1(1), GNGT1(1), GRB2(2), JAK2(4), MAP2K1(2), MAP2K2(1), MAPK3(1), MAPK8(6), MAPT(1), MYLK(5), PLCG1(1), PRKCA(3), PTK2B(1), RAF1(4), SHC1(1), SOS1(3), STAT1(1), STAT3(1)	7668714	48	19	48	15	12	18	12	1	4	1	0.37	0.63
363	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLUD2(3)	792136	3	3	3	1	0	2	1	0	0	0	0.38	0.64
364	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(2), IGF1(1), IL3(1), IL6(2), IL9(2), KITLG(1), TGFB1(1), TGFB2(4)	1545104	14	7	14	7	4	6	2	0	2	0	0.38	0.64
365	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS1(1), DHRS2(1), DHRS3(1), PON1(1), PON2(1), RDH11(1), RDH12(2)	1536472	8	7	8	5	4	3	0	0	1	0	0.38	0.64
366	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(1), ACO1(3), CLYBL(1), DLD(1), DLST(1), IDH1(1), IDH2(1), IDH3A(3), OGDH(2), OGDHL(5), PC(4), PCK1(3), PCK2(2), SDHA(1), SUCLA2(3), SUCLG1(1)	5495846	33	19	33	14	9	11	8	0	5	0	0.38	0.64
367	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACOT11(2), ACYP1(2), DHRS1(1), DHRS2(1), DHRS3(1), ECHS1(1), ESCO1(6), ESCO2(1), GCDH(3), HADHA(1), ITGB1BP3(1), MYST3(10), MYST4(7), SH3GLB1(1)	4623200	38	17	38	12	13	10	9	1	5	0	0.38	0.64
368	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(3), AFMID(1), GRHPR(1), HAO2(1), MTHFD1(4), MTHFD1L(3)	2474084	13	11	13	6	4	7	0	1	1	0	0.38	0.64
369	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), TAT(3)	480180	5	3	5	1	1	3	0	0	1	0	0.38	0.64
370	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1)	1463172	13	9	13	3	6	4	2	0	1	0	0.38	0.64
371	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1)	1463172	13	9	13	3	6	4	2	0	1	0	0.38	0.64
372	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(2), CPS1(7), GOT1(2)	1404110	11	6	11	3	3	4	1	0	3	0	0.39	0.64
373	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(3), BCMO1(1)	709252	5	5	5	1	3	1	1	0	0	0	0.39	0.64
374	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	IDH2(1), OGDH(2), SDHA(1), SUCLA2(3)	1735670	7	7	7	5	0	4	2	0	1	0	0.39	0.64
375	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT5(2), FUT1(3), FUT3(2), ST3GAL3(3), ST3GAL4(1)	1293926	11	7	11	2	6	1	4	0	0	0	0.39	0.64
376	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(5), GNAS(2), PLCE1(2), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), RAP2B(1)	2600718	17	11	17	4	6	7	3	0	1	0	0.39	0.64
377	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR2(1), ACTR3(1), ARPC1B(1), ARPC2(1), NCK1(1), NCKAP1(3), NTRK1(3), PIR(1), PSMA7(1), WASF1(2), WASF2(1), WASF3(4), WASL(2)	2842158	23	11	23	3	7	9	3	0	4	0	0.39	0.64
378	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ECHS1(1), HADHA(1), SDS(1)	2231758	16	11	16	5	7	4	2	0	3	0	0.40	0.65
379	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(2), CDKN1A(1), NEK1(2)	1394752	6	6	6	0	2	2	0	2	0	0	0.40	0.65
380	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	IL12A(1), IL12B(1), IL2(2)	562486	4	3	4	1	0	4	0	0	0	0	0.40	0.65
381	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(4), G6PD(3), GPX3(2), GPX5(2), GSS(1), GSTA3(1), GSTM3(1), GSTM4(1), GSTO2(1), GSTZ1(1), IDH1(1), IDH2(1)	3275946	19	13	19	3	3	11	4	0	1	0	0.40	0.65
382	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(4), PLCB1(1), PRKCA(3)	1504870	9	5	9	6	5	2	0	1	1	0	0.41	0.66
383	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), HLA-DRA(3), HLA-DRB1(1)	370956	5	3	5	0	2	3	0	0	0	0	0.41	0.66
384	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(1), AASS(2)	871590	4	4	4	2	0	1	2	0	1	0	0.41	0.66
385	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(1), ME1(3), PC(4), PDHA1(1), SLC25A11(1)	1682666	10	8	10	4	8	2	0	0	0	0	0.41	0.66
386	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(4), ACADVL(1), ACSL3(1), ACSL4(1), CPT1A(3), CPT2(2), HADHA(1), SCP2(1), SLC25A20(1)	3066288	17	11	17	8	5	5	4	0	3	0	0.42	0.66
387	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CSF1(1), HLA-DRA(3), HLA-DRB1(1), IL10(1), IL12A(1), IL12B(1), IL15(1), IL2(2), IL3(1), IL4(1), IL6(2), IL7(1), IL8(1), TGFB1(1), TGFB2(4)	2343830	22	9	22	6	6	12	2	0	2	0	0.42	0.66
388	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(2), CASP3(1), CASP9(1), DAXX(1), FAS(2), HSPB2(1)	2005770	9	7	9	3	1	1	5	0	2	0	0.42	0.66
389	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	FOS(1), GRB2(2), IL2(2), IL2RB(1), JAK1(1), JAK3(4), LCK(2), MAP2K1(2), MAPK3(1), MAPK8(6), RAF1(4), SHC1(1), SOS1(3), STAT5B(1), SYK(3)	4273464	34	15	34	5	7	14	6	1	6	0	0.42	0.67
390	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(1), CASP3(1), CASP8(5), CRADD(1), DFFA(2), DFFB(1), LMNB1(3), MADD(6), MAP2K4(2), MAP3K1(2), MAP3K7(2), MAPK8(6), PAK1(1), PAK2(3), PRKDC(5), RB1(3), SPTAN1(7)	7246438	53	24	52	19	17	13	12	1	10	0	0.43	0.68
391	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(2)	325350	4	3	4	0	1	2	1	0	0	0	0.43	0.68
392	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(2), AGTR1(3), AGTR2(1), COL4A1(5), COL4A2(1), COL4A3(1), COL4A4(2), COL4A5(5), COL4A6(5), REN(2)	4777490	30	15	30	8	10	9	6	1	4	0	0.43	0.68
393	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CHUK(4), CREBBP(8), EP300(8), HDAC3(1), IKBKB(2), NFKB1(4), TRAF6(1)	4067752	28	15	28	8	12	9	4	1	2	0	0.43	0.68
394	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), ADSS(1), DHFR(1), IMPDH1(2), POLB(3), POLD1(2), POLG(2), PRPS2(1), RRM1(2)	2336086	16	12	16	4	8	6	1	0	1	0	0.43	0.68
395	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BAG4(1), BIRC2(2), BIRC3(5), CASP3(1), CASP8(5), CFLAR(1), MAP2K4(2), MAP3K3(2), MAP3K7(2), NFKB1(4), NFKB2(2), NR2C2(1), RALBP1(2), TNFAIP3(1)	4744694	31	16	31	8	10	9	7	0	5	0	0.44	0.68
396	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(3), HDAC9(2), MEF2A(1), MEF2C(2), YWHAH(1)	1543128	11	6	11	7	1	6	1	0	3	0	0.44	0.68
397	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(5), ACACB(5), OLAH(1), OXSM(2)	2573408	13	10	13	7	4	5	1	0	3	0	0.44	0.68
398	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(3), CYP2A6(3), XDH(1)	1464878	9	7	9	6	3	3	2	0	1	0	0.44	0.69
399	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(2), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH7A1(2), CYP2C9(5), DHRS1(1), DHRS2(1), DHRS3(1), ECHS1(1), ESCO1(6), ESCO2(1), HADHA(1), MYST3(10), MYST4(7), SH3GLB1(1)	5545920	48	18	48	12	14	15	12	1	6	0	0.45	0.69
400	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25A(1), CDC25B(2), CDC25C(1), MNAT1(1), XPO1(1)	1572344	7	6	7	4	3	2	0	1	1	0	0.45	0.69
401	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAA2(1), ACAD8(1), ACAD9(4), ADH1A(1), ADH1B(2), ADH1C(1), ADH4(2), ADH6(2), ADH7(1), ADHFE1(3), AKR1C4(1), AKR1D1(1), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH7A1(2), CYP27A1(1), CYP7A1(1), HADHB(1), RDH11(1), RDH12(2), SLC27A5(1), SRD5A1(1), SRD5A2(1)	5861650	41	22	41	18	10	19	10	0	2	0	0.45	0.70
402	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(3), CDKN1A(1), GRIN1(1), HIF1A(3), JAK2(4), NFKB1(4)	2340732	16	9	16	6	5	5	2	0	3	1	0.46	0.70
403	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(3), CCNA2(1), CCNE1(1), CCNE2(1), CDK4(1), CDKN1B(2), PRB1(1)	1587780	10	6	10	4	2	2	2	0	4	0	0.46	0.70
404	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(2), MTMR2(1), NFS1(1), PHPT1(1), TPK1(3)	1169534	9	6	9	3	5	1	2	0	1	0	0.46	0.70
405	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2)	283888	2	2	2	0	0	1	1	0	0	0	0.46	0.70
406	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(3), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1)	2799818	15	10	15	6	4	6	4	0	1	0	0.46	0.70
407	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(3), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1)	2799818	15	10	15	6	4	6	4	0	1	0	0.46	0.70
408	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(3), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1)	2799818	15	10	15	6	4	6	4	0	1	0	0.46	0.70
409	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(4), G6PD(3), GPX3(2), GPX5(2), GPX6(1), GSS(1), GSTA3(1), GSTA5(1), GSTM3(1), GSTM4(1), GSTO2(1), GSTZ1(1), IDH1(1), IDH2(1), TXNDC12(2)	3859006	23	15	23	3	4	13	5	0	1	0	0.46	0.70
410	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CSF1(1), IL6(2), LDLR(1), LPL(2)	968554	6	5	6	2	4	1	0	0	1	0	0.47	0.70
411	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX5(1), CYP4F2(2), CYP4F3(1), EPX(1), LPO(1), MPO(2), PLA2G4A(4), PLA2G6(2), PRDX1(1), PTGIS(2), PTGS1(4), PTGS2(1), TBXAS1(3), TPO(4)	5067506	31	19	31	13	16	9	3	0	3	0	0.47	0.70
412	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ALDH1A3(4), ALDH3B1(1), ALDH3B2(1), AOC2(1), AOC3(1), EPX(1), ESCO1(6), ESCO2(1), GOT1(2), HPD(2), LPO(1), MAOA(3), MAOB(1), MPO(2), MYST3(10), MYST4(7), SH3GLB1(1), TAT(3), TPO(4)	6226298	52	23	52	20	18	20	10	1	3	0	0.47	0.70
413	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CARM1(1), CBS(2), CTH(1), LCMT1(2), MARS(4), MARS2(1), MAT1A(2), MAT2B(1), METTL2B(1), METTL6(3), PAPSS1(1), PAPSS2(2), PRMT3(1), PRMT7(2), PRMT8(2), SEPHS1(2), WBSCR22(1)	4504020	29	16	29	7	9	10	4	2	4	0	0.47	0.70
414	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(1), ACO1(3), ACSS1(1), ACSS2(1), IDH1(1), IDH2(1), SUCLA2(3)	2434746	11	8	11	8	3	6	0	0	2	0	0.47	0.70
415	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(1), CASP3(1), CASP6(2), CASP7(1), CASP8(5), CFLAR(1), DAXX(1), DFFA(2), DFFB(1), FAF1(3), LMNB1(3), MAP2K4(2), MAP3K1(2), MAP3K7(2), MAPK8(6), PAK1(1), PAK2(3), PRKDC(5), PTPN13(9), RB1(3), RIPK2(1), SPTAN1(7)	7870544	63	23	62	14	13	24	14	1	11	0	0.47	0.70
416	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), TGDS(1), UGDH(1), UGP2(3), UXS1(1)	934744	7	4	7	0	1	3	1	0	2	0	0.48	0.71
417	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX3(3), FADS2(1), PLA2G4A(4), PLA2G6(2)	1899676	10	7	10	3	7	1	0	0	2	0	0.48	0.71
418	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1), LIPT1(2)	279258	3	2	3	1	0	2	1	0	0	0	0.48	0.71
419	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(2), B3GALT5(2), FUT1(3), FUT9(2), GLA(1), HEXB(2), ST3GAL2(1)	1884644	13	8	13	5	7	3	3	0	0	0	0.48	0.71
420	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(2), AASDHPPT(1), AASS(2)	1279732	6	5	6	3	0	3	2	0	1	0	0.49	0.71
421	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CDC42(1), DAXX(1), GRB2(2), HSPB2(1), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K5(3), MAP3K7(2), MAP3K9(4), MEF2A(1), MEF2C(2), MKNK1(1), PLA2G4A(4), RPS6KA5(4), SHC1(1), STAT1(1), TGFB1(1), TGFB2(4), TGFBR1(5)	6751124	44	18	44	11	13	12	9	0	10	0	0.49	0.71
422	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(2), DIAPH2(6), MCM10(4), MCM3(2), MCM4(1), MCM5(5), MCM6(1), MCM7(2), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(1), POLA2(2), POLD1(2), POLD2(1), POLD3(1), POLE(10), POLE2(1), RFC1(4), RFC5(1), RPA4(1), UBB(1)	9237568	53	23	52	17	18	24	4	0	7	0	0.49	0.71
423	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA4(1), NDUFB6(1), NDUFS1(2), NDUFS2(3)	1293062	7	5	7	4	3	2	1	0	1	0	0.50	0.71
424	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(1), AOC3(1), CES1(2), ESD(1)	1056596	5	5	5	6	1	4	0	0	0	0	0.50	0.71
425	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(2), HK3(1), IMPA1(1), PGM1(3), PGM3(2), TGDS(1)	1846130	11	8	11	3	4	5	2	0	0	0	0.50	0.71
426	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(2), KHK(1), LCT(11), PGM1(3), PYGM(3)	2492302	20	13	20	2	11	4	5	0	0	0	0.50	0.71
427	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL13RA2(2), JAK1(1), JAK2(4)	1910018	9	6	9	5	1	3	3	0	1	1	0.50	0.71
428	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL13RA2(2), JAK1(1), JAK2(4)	1910018	9	6	9	5	1	3	3	0	1	1	0.50	0.71
429	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(1), ADH1B(2), ADH1C(1), ADH4(2), ADH6(2), ADH7(1), ADHFE1(3), ALDH1A1(1), ALDH1A2(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH3B1(1), ALDH3B2(1), ALDOB(2), ALDOC(2), DLAT(1), DLD(1), ENO2(2), ENO3(2), FBP2(1), G6PC(1), GCK(1), GPI(1), HK1(2), HK3(1), LDHA(2), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PFKM(3), PFKP(2), PGK1(1), PGM1(3), PGM3(2)	8864350	67	27	67	24	25	21	16	0	5	0	0.50	0.71
430	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(1), ADH1B(2), ADH1C(1), ADH4(2), ADH6(2), ADH7(1), ADHFE1(3), ALDH1A1(1), ALDH1A2(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH3B1(1), ALDH3B2(1), ALDOB(2), ALDOC(2), DLAT(1), DLD(1), ENO2(2), ENO3(2), FBP2(1), G6PC(1), GCK(1), GPI(1), HK1(2), HK3(1), LDHA(2), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PFKM(3), PFKP(2), PGK1(1), PGM1(3), PGM3(2)	8864350	67	27	67	24	25	21	16	0	5	0	0.50	0.71
431	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(2), CTH(1), MARS(4), MARS2(1), MAT1A(2), MAT2B(1), PAPSS1(1), PAPSS2(2), SEPHS1(2)	2241632	16	9	16	4	4	7	3	0	2	0	0.50	0.71
432	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(5), ACACB(5), ACOT12(5), ACSS1(1), ACSS2(1), ACYP1(2), AKR1B1(1), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH7A1(2), DLAT(1), DLD(1), GRHPR(1), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHB(2), LDHC(1), LDHD(1), ME1(3), ME3(3), PC(4), PCK1(3), PCK2(2), PDHA1(1), PDHA2(4)	8485218	63	24	63	26	19	25	9	1	9	0	0.50	0.71
433	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(1), ARSB(1), ARSD(1), CYP11B1(4), HSD17B2(1), HSD17B3(1), HSD3B1(1), HSD3B2(1), SRD5A1(1), SRD5A2(1), STS(1), SULT1E1(1), SULT2A1(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(2)	4734292	23	15	23	7	6	11	2	0	4	0	0.50	0.71
434	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG5(1), BECN1(1), IFNA10(3), IFNA2(2), IFNA5(1), PIK3C3(5), PIK3R4(4), PRKAA1(1), PRKAA2(4), ULK1(1)	3756230	24	12	24	3	5	8	6	0	5	0	0.51	0.71
435	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	GOT1(2), TAT(3), TYR(1)	858990	6	4	6	2	2	3	0	0	1	0	0.51	0.71
436	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(4), AMY2A(2), AMY2B(1), ENPP3(2), G6PC(1), GANAB(1), GBE1(1), GCK(1), GPI(1), GUSB(1), GYS1(2), GYS2(4), HK1(2), HK3(1), MGAM(4), PGM1(3), PGM3(2), PYGB(1), PYGM(3), SI(4), UCHL1(2), UCHL3(1), UGDH(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(2), UXS1(1)	10241350	52	21	52	14	14	17	13	0	8	0	0.51	0.71
437	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(2), ALDOC(2), DERA(1), FBP2(1), G6PD(3), GPI(1), H6PD(2), PFKM(3), PFKP(2), PGM1(3), PGM3(2), PRPS1(1), PRPS2(1), TALDO1(2), TKT(1), TKTL1(3), TKTL2(3)	4375808	33	19	33	10	14	15	2	0	2	0	0.51	0.71
438	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP2(10)	1509262	12	6	12	3	2	4	6	0	0	0	0.51	0.71
439	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(2), HSD17B2(1), HSD17B3(1), HSD17B4(1), HSD3B1(1), HSD3B2(1)	1462344	7	5	7	3	1	3	2	0	1	0	0.51	0.71
440	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(2), FUCA1(2), HEXB(2), LCT(11), MANBA(5), NEU1(1)	2917678	23	12	23	4	7	7	6	0	3	0	0.51	0.72
441	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(1), GNS(3), GUSB(1), HEXB(2), LCT(11), NAGLU(2)	2631970	21	12	21	5	8	6	5	0	2	0	0.52	0.72
442	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F11(1), F13B(2), F2(2), F5(10), F7(1), F8(5), FGA(6), FGB(1), FGG(2), LPA(1), PLAT(3), PLAU(1), PLG(4), SERPINB2(1), SERPINE1(3), VWF(7)	6324806	50	21	50	20	14	25	7	0	4	0	0.52	0.72
443	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), CD38(2), ENPP3(2), NADK(2), NADSYN1(1), NMNAT1(1), NMNAT2(1), NMNAT3(1), NNMT(3), NNT(3), NT5C1A(1), NT5C1B(5), NT5C2(2), NT5E(1)	3967292	28	16	28	11	10	9	5	0	4	0	0.52	0.72
444	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), ETV5(3), IL12A(1), IL12B(1), IL12RB2(2), IL18R1(4), JAK2(4), MAP2K6(1), MAPK8(6), STAT4(3)	3424790	26	12	26	5	1	11	9	1	3	1	0.52	0.72
445	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(2), NR3C1(1), PPARG(1)	994466	4	4	4	4	0	1	1	0	2	0	0.52	0.72
446	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(5), GNAS(2), GNGT1(1), GRB2(2), IGF1R(2), KLK2(3), MAP2K1(2), MAP2K2(1), MAPK3(1), MKNK1(1), MKNK2(1), NGFR(1), PDGFRA(4), PPP2CA(1), PTPRR(4), RAF1(4), RPS6KA5(4), SHC1(1), SOS1(3), SRC(3), STAT3(1)	6012048	47	21	45	15	15	17	12	0	2	1	0.53	0.73
447	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(4), CD33(1), CD5(3), IL10(1), IL12A(1), IL12B(1), IL3(1), IL4(1), ITGAX(2), TLR2(4), TLR4(4), TLR7(5), TLR9(4)	3391860	32	14	32	5	9	13	9	0	1	0	0.53	0.73
448	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(2), HK3(1), IMPA1(1), IMPA2(1), PGM1(3), PGM3(2), TGDS(1)	2072792	12	9	12	3	5	5	2	0	0	0	0.53	0.73
449	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ITGAL(4), ITGAM(3), ITGB2(2), PECAM1(1), SELE(2), SELL(3)	2051062	17	9	17	7	4	9	2	0	2	0	0.53	0.73
450	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP2(1), ACPP(2), ENPP3(2), FLAD1(1), LHPP(1), MTMR1(2), MTMR2(1), PHPT1(1), TYR(1)	2759858	12	10	12	10	6	1	3	0	1	1	0.54	0.73
451	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(3), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), SHMT1(1)	2957068	15	10	15	6	4	6	4	0	1	0	0.54	0.73
452	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(1), ALAS2(3), CPOX(1), FECH(1), PPOX(1), UROD(1)	1417428	9	6	9	3	5	2	2	0	0	0	0.54	0.74
453	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), GRB2(2), IL4(1), IRS1(4), JAK1(1), JAK3(4), SHC1(1), STAT6(1)	2628144	15	9	15	3	2	8	2	0	3	0	0.54	0.74
454	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15B(1), ALOX5(1), PLA2G6(2), PTGIS(2), PTGS1(4), PTGS2(1), TBXAS1(3)	2723648	14	12	14	5	6	5	3	0	0	0	0.54	0.74
455	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(6), ABCB11(3), ABCB4(6), ABCC1(3), ABCC3(2)	2668386	20	9	20	8	4	8	5	1	2	0	0.55	0.74
456	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(1), EPX(1), LPO(1), MPO(2), MTHFR(3), SHMT1(1), SHMT2(1), TPO(4)	2131884	14	10	14	8	7	4	3	0	0	0	0.55	0.74
457	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(4), MAP3K14(1), MAPK8(6), NFKB1(4), TNFRSF17(2), TNFSF13B(1), TRAF3(2), TRAF5(3), TRAF6(1)	2690512	24	11	24	6	9	5	7	1	2	0	0.55	0.74
458	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(5), AP2A1(1), BIN1(1), DNM1(4), EPN1(1), EPS15(3), PPP3CA(2), PPP3CB(2), PPP3CC(3), SYNJ1(4), SYNJ2(1)	4154042	27	12	27	8	9	8	2	0	8	0	0.56	0.76
459	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(1), HADHA(1), SDS(1)	891806	3	3	3	2	1	0	0	0	2	0	0.57	0.76
460	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(1), AASS(2), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH7A1(2), BBOX1(2), DLST(1), ECHS1(1), EHMT2(3), GCDH(3), HADH(1), HADHA(1), HSD17B10(1), HSD17B4(1), NSD1(4), OGDH(2), OGDHL(5), PIPOX(1), PLOD1(2), PLOD2(1), PLOD3(1), RDH11(1), RDH12(2), SETD1A(3), SETD7(2), SETDB1(4), SHMT1(1), SHMT2(1), SPCS1(1), SPCS3(1), SUV39H1(1), SUV39H2(1), TMLHE(2)	10330230	65	24	65	20	25	16	11	0	13	0	0.57	0.77
461	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), ABAT(1), ADSL(2), ADSS(1), ASL(2), ASPA(2), CAD(4), CRAT(2), DARS(3), GAD1(2), GAD2(2), GOT1(2), GPT2(1), NARS(2), PC(4)	4757104	32	18	32	17	16	10	5	0	1	0	0.58	0.77
462	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGEF2(4), CLTA(2), COPA(2), GBF1(7), GPLD1(4), KDELR2(1), KDELR3(1)	2964972	21	11	20	6	7	6	4	1	3	0	0.58	0.77
463	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), ATIC(1), DHFR(1), GART(1), MTHFD1(4), MTHFD1L(3), MTHFR(3), MTHFS(1), MTR(1), SHMT1(1), SHMT2(1), TYMS(2)	3297446	22	14	22	4	8	8	5	0	1	0	0.58	0.77
464	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS(3), IARS2(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(4), VARS2(2)	3031136	13	11	13	7	5	2	5	0	1	0	0.59	0.77
465	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(5), ABCG2(5), BCHE(6), CES1(2), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1)	4168280	25	14	25	5	8	11	4	1	1	0	0.59	0.77
466	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(1), ADC(1), AGMAT(4), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH7A1(2), AMD1(1), AOC2(1), AOC3(1), ARG2(2), ASL(2), ASS1(1), CPS1(7), MAOA(3), MAOB(1), NAGS(1), ODC1(4), OTC(2), SAT2(1)	5418414	44	18	43	13	14	17	6	0	7	0	0.59	0.77
467	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG2(1), ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(4), CDC42(1), FLNA(1), FLNC(2), LIMK1(2), MYH2(5), MYLK(5), MYLK2(2), PAK1(1), PAK2(3), PAK3(3), PAK7(3), RHO(2), ROCK1(8), ROCK2(4), RPS4X(1), WASF1(2), WASL(2)	8451086	55	24	55	13	23	16	6	0	10	0	0.59	0.77
468	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(4), DUSP1(2), IKBKAP(1), IKBKB(2), MAP3K1(2), MAP3K14(1), NFKB1(4), TNFAIP3(1), TRAF3(2), TRAF6(1)	3411268	20	12	20	5	7	7	5	0	1	0	0.59	0.77
469	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	CAT(1), EPX(1), LPO(1), MPO(2), PRDX1(1), SHMT1(1), SHMT2(1), TPO(4)	2168516	12	9	12	9	6	4	1	0	1	0	0.59	0.77
470	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(1), AKT2(2), AKT3(1), BCR(2), BTK(2), CD19(1), DAPP1(1), GAB1(1), ITPR1(8), ITPR2(6), ITPR3(7), PDK1(2), PIK3CA(7), PLCG2(4), PPP1R13B(1), PREX1(4), PTEN(4), PTPRC(9), RPS6KA2(4), RPS6KA3(2), SYK(3), TEC(2), VAV1(7)	10184842	81	27	81	23	25	30	14	0	11	1	0.59	0.78
471	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(1), ADCY3(2), ADCY9(2), ARF4(2), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0B(1), ATP6V0D2(4), ATP6V1C2(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), ERO1L(1), GNAS(2), PDIA4(4), PLCG1(1), PLCG2(4), PRKCA(3), SEC61A1(1), TRIM23(4)	6705474	44	21	44	15	18	13	10	0	3	0	0.60	0.78
472	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(2), GABRA2(3), GABRA3(3), GABRA4(2), GABRA5(1), GABRA6(1), PRKCE(2)	1447048	14	5	14	6	2	10	1	0	1	0	0.60	0.78
473	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(4), ALDH3B1(1), ALDH3B2(1), AOC2(1), AOC3(1), EPX(1), GOT1(2), HPD(2), LPO(1), MAOA(3), MAOB(1), MPO(2), PRDX1(1), TAT(3), TPO(4)	4021724	28	17	28	15	10	13	2	0	3	0	0.60	0.78
474	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP2(1), ACPP(2), ENPP3(2), FLAD1(1), TYR(1)	1791284	7	6	7	5	2	1	3	0	0	1	0.60	0.78
475	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), AOC2(1), AOC3(1), CES1(2), CES7(1), DDHD1(2), ESCO1(6), ESCO2(1), MYST3(10), MYST4(7), SH3GLB1(1)	4612140	33	16	33	13	10	11	9	1	2	0	0.60	0.78
476	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(2), BID(1), BIRC2(2), BIRC3(5), CASP10(1), CASP3(1), CASP6(2), CASP7(1), CASP8(5), CASP9(1), CFLAR(1), CHUK(4), DFFA(2), DFFB(1), MAP3K14(1), NFKB1(4), SPTAN1(7), TNFRSF10B(4)	6142536	45	19	45	16	15	14	8	0	8	0	0.60	0.78
477	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), HLA-DRA(3), HLA-DRB1(1), IFNGR1(1), IFNGR2(1), IL12A(1), IL12B(1), IL12RB2(2), IL18R1(4), IL2(2), IL4(1)	2273702	18	8	18	4	4	9	3	0	2	0	0.60	0.78
478	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), TGDS(1), UGDH(1), UXS1(1)	743570	4	3	4	0	1	2	0	0	1	0	0.61	0.78
479	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(3), POLD1(2), POLD2(1), POLE(10), POLG(2), POLL(1), POLQ(5)	3106712	24	12	23	6	9	8	3	0	4	0	0.61	0.78
480	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT1(2), FBP2(1), G6PC(1), GALK2(2), GALT(1), GANAB(1), GCK(1), GLA(1), HK1(2), HK3(1), LALBA(1), LCT(11), MGAM(4), PFKM(3), PFKP(2), PGM1(3), PGM3(2)	5922694	40	21	40	8	18	14	7	0	1	0	0.62	0.79
481	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ITGA4(5), ITGAL(4), ITGAM(3), ITGB2(2), PECAM1(1), SELE(2), SELL(3), SELP(2)	3066388	24	11	24	10	5	12	4	0	3	0	0.62	0.79
482	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(7), ATP4B(1), ATP6V0A1(3), ATP6V0A4(3), ATP6V0B(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), ATP7A(3), COX4I1(1), NDUFA4(1), NDUFB6(1), NDUFS1(2), NDUFS2(3), PPA2(2), SDHA(1), SHMT1(1)	6908068	37	20	37	20	10	18	6	0	3	0	0.62	0.79
483	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(1), CASP7(1), DFFA(2), DFFB(1), GZMB(2), TOP2A(3), TOP2B(4)	1928716	14	5	14	2	2	5	4	0	3	0	0.62	0.79
484	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(2), ALDOC(2), FBP2(1), GOT1(2), GPT2(1), ME1(3), ME3(3), PGK1(1), PGK2(1), TKT(1), TKTL1(3), TKTL2(3)	3602002	23	15	23	15	11	8	3	0	1	0	0.62	0.79
485	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(1), AKT1(1), AKT2(2), AKT3(1), DAG1(3), GNAQ(1), ITPR1(8), ITPR2(6), ITPR3(7), NFKB1(4), NFKB2(2), PDK1(2), PHKA2(3), PIK3CB(1), PLD1(6), PLD2(1), PLD3(1)	8124728	50	19	50	11	21	14	6	1	7	1	0.62	0.79
486	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG2(2), ASL(2), ASS1(1), CKM(1), CKMT2(3), CPS1(7), DAO(4), EPRS(4), GLUD2(3), GOT1(2), LAP3(1), NOS1(6), OAT(1), OTC(2), P4HA1(1), P4HA3(1), RARS(3), RARS2(2)	6406640	47	17	47	17	15	18	6	1	7	0	0.63	0.79
487	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), ATIC(1), DHFR(1), GART(1), MTFMT(1), MTHFD1(4), MTHFD1L(3), MTHFR(3), MTHFS(1), MTR(1), SHMT1(1), SHMT2(1), TYMS(2)	3454438	23	14	23	4	8	9	5	0	1	0	0.63	0.80
488	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(4), EGR2(3), GNAQ(1), MAP3K1(2), NFATC1(1), NFATC2(3), NFKB1(4), PLCG1(1), PPP3CA(2), PPP3CB(2), PPP3CC(3), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), VIPR2(1)	4886618	34	16	34	11	16	7	6	0	5	0	0.63	0.80
489	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(2), ALDOC(2), FBP2(1), G6PD(3), GPI(1), H6PD(2), PFKM(3), PFKP(2), PGM1(3), PGM3(2), PRPS1(1), PRPS2(1), TALDO1(2), TKT(1)	3681812	26	15	26	8	12	12	1	0	1	0	0.63	0.80
490	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(3), FUT9(2), GLA(1), HEXB(2), ST3GAL2(1), ST3GAL4(1)	1773310	10	7	10	4	4	3	3	0	0	0	0.64	0.81
491	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), GPI(1), HK1(2), PGK1(1)	1579986	6	6	6	5	1	2	3	0	0	0	0.64	0.81
492	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	CSAD(2), GAD1(2), GAD2(2)	1047182	6	5	6	5	4	2	0	0	0	0	0.65	0.81
493	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ALAS1(1), ALAS2(3), AOC2(1), AOC3(1), BHMT(3), CBS(2), CHDH(2), CHKA(2), CPT1B(1), CTH(1), DAO(4), DLD(1), DMGDH(2), GCAT(1), GLDC(1), MAOA(3), MAOB(1), PEMT(1), PISD(2), PLCG1(1), PLCG2(4), SARDH(2), SARS(1), SHMT1(1), SHMT2(1), TARS(4)	7706250	47	22	47	19	20	16	6	0	5	0	0.65	0.81
494	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2D(2), DAG1(3), ITPR1(8), ITPR2(6), ITPR3(7), PDE6A(3), PDE6B(4), PDE6C(3), SLC6A13(2), TF(6)	6629148	44	18	44	6	17	14	7	0	5	1	0.65	0.81
495	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(2), ARHGDIB(1), BAG4(1), BID(1), BIRC2(2), BIRC3(5), CASP2(1), CASP3(1), CASP6(2), CASP7(1), CASP8(5), CASP9(1), CFLAR(1), CHUK(4), CRADD(1), DAXX(1), DFFA(2), DFFB(1), LMNB1(3), MAP3K1(2), MAP3K14(1), MAP3K5(3), MAPK8(6), NFKB1(4), NUMA1(5), PAK2(3), PRKDC(5), PTK2(1), RASA1(5), RB1(3), SPTAN1(7), TRAF1(1)	12683506	82	26	81	19	24	25	19	1	13	0	0.65	0.81
496	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), ITGAL(4), ITGB2(2), PTPRC(9)	1937232	16	7	16	7	4	7	2	0	3	0	0.66	0.81
497	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(1), EIF2B5(3), EIF5(1), GSK3B(2)	2096620	8	7	8	2	2	4	2	0	0	0	0.66	0.81
498	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), GUSB(1), UGDH(1), UGP2(3), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2A3(2), UGT2B11(2), UGT2B17(4), UGT2B28(1), UGT2B4(2), UGT2B7(2), XYLB(1)	4556424	24	10	24	4	2	12	5	0	5	0	0.66	0.81
499	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ALAS1(1), ALAS2(3), AOC2(1), AOC3(1), BHMT(3), CBS(2), CHDH(2), CHKA(2), CTH(1), DAO(4), DLD(1), DMGDH(2), GCAT(1), GLDC(1), GNMT(1), MAOA(3), MAOB(1), PEMT(1), PIPOX(1), PISD(2), PSAT1(3), RDH11(1), RDH12(2), SARDH(2), SARS(1), SDS(1), SHMT1(1), SHMT2(1), TARS(4), TARS2(2)	7879554	52	22	52	23	22	20	6	0	4	0	0.66	0.81
500	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), LPO(1), MPO(2), PRDX1(1), TPO(4), TYR(1)	1773914	10	7	10	6	6	3	0	0	1	0	0.66	0.81
501	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	FOS(1), KEAP1(1), MAPK8(6), NFE2L2(3), PRKCA(3)	1551000	14	7	14	0	5	5	2	1	1	0	0.66	0.81
502	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ITGA4(5), ITGAL(4), ITGB2(2), PECAM1(1), SELE(2), SELL(3)	2323108	19	8	19	7	3	10	4	0	2	0	0.66	0.81
503	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(1), ALDH1A1(1), ALDH1A2(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH5A1(2), ECHS1(1), GAD1(2), GAD2(2), HADHA(1), HMGCL(1), PDHA1(1), PDHA2(4), SDS(1)	4720738	30	18	30	16	16	7	4	0	3	0	0.67	0.82
504	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22RA1(1), JAK1(1), JAK2(4), JAK3(4), STAT1(1), STAT3(1), STAT5B(1)	3345598	14	10	14	7	1	6	3	0	3	1	0.67	0.82
505	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), GNAQ(1), GNGT1(1), HTR2C(2), PLCB1(1), TUB(2)	1299738	8	4	8	6	3	2	1	1	1	0	0.68	0.82
506	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SRP54(3), SRP68(3), SRP72(1), SRPR(1)	1375068	10	5	10	3	2	6	1	0	1	0	0.68	0.82
507	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(1), ACYP1(2), ADH1A(1), ADH1B(2), ADH1C(1), ADH4(2), ADH6(2), ADH7(1), ADHFE1(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH3B1(1), ALDH3B2(1), ALDH7A1(2), ALDOB(2), ALDOC(2), DLAT(1), DLD(1), ENO2(2), ENO3(2), FBP2(1), G6PC(1), G6PC2(1), GCK(1), GPI(1), HK1(2), HK3(1), LDHA(2), LDHAL6A(2), LDHAL6B(1), LDHB(2), LDHC(1), PDHA1(1), PDHA2(4), PFKM(3), PFKP(2), PGK1(1), PGK2(1), PGM1(3), PGM3(2)	10494640	72	27	72	27	23	26	17	0	6	0	0.68	0.82
508	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(1), IFNGR2(1), JAK1(1), JAK2(4), STAT1(1)	1510482	8	4	8	1	1	2	2	0	2	1	0.68	0.82
509	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), ITGAL(4), ITGB2(2), PTPRC(9)	2049192	16	7	16	7	4	7	2	0	3	0	0.69	0.83
510	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), DDX20(1), ETS1(1), ETS2(1), ETV3(1), FOS(1), HDAC5(1), RBL1(4), RBL2(3), SIN3A(8), SIN3B(3)	4780998	25	14	25	11	11	10	2	0	2	0	0.69	0.83
511	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(1), GNS(3), GUSB(1), HEXB(2), HPSE2(3), LCT(11), NAGLU(2), SPAM1(4)	3762830	28	14	28	6	11	8	6	1	2	0	0.70	0.84
512	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL2(1), ST3GAL4(1), ST6GALNAC2(2), ST6GALNAC4(2)	1031022	7	6	7	2	1	3	3	0	0	0	0.70	0.84
513	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), GUSB(1), UCHL1(2), UCHL3(1), UGDH(1), UGT1A4(1), UGT1A6(1), UGT1A8(1), UGT1A9(1), UGT2B4(2)	2949112	12	7	12	3	2	7	0	0	3	0	0.70	0.84
514	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(3), PSAT1(3)	886042	6	3	6	1	1	4	0	0	1	0	0.70	0.84
515	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(3), PDE1A(2), PDE1B(2), PLCB1(1), PRL(1), TRH(2)	2020516	11	7	11	4	4	4	1	2	0	0	0.71	0.84
516	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(3), GNAQ(1)	1035730	5	4	5	1	1	2	1	0	1	0	0.71	0.84
517	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	FYN(1), HLA-DRA(3), HLA-DRB1(1), LCK(2), PTPRC(9), ZAP70(1)	1597490	17	6	17	1	4	8	3	0	2	0	0.71	0.84
518	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	CD44(2), CSF1(1), FCGR3A(1), IL1B(1), IL6R(1), SELL(3), SPN(1), TGFB1(1), TGFB2(4), TNFRSF8(1)	2459630	16	7	16	6	4	4	4	0	4	0	0.71	0.84
519	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CHUK(4), FOS(1), IKBKB(2), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK8(6), MYD88(1), NFKB1(4), PPARA(1), TLR10(3), TLR2(4), TLR3(2), TLR4(4), TLR6(1), TLR7(5), TLR9(4), TOLLIP(1), TRAF6(1)	6697938	56	19	56	16	18	18	14	2	3	1	0.71	0.85
520	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	GOSR1(1), GOSR2(1), SEC22B(1), SNAP23(1), SNAP29(1), STX11(1), STX16(1), STX17(1), STX18(1), STX19(1), STX2(1), STX3(1), STX7(1), STX8(2), VAMP1(1), VAMP3(2), VAMP4(1), VAMP5(1), VTI1A(1), YKT6(1)	2976602	22	10	22	11	6	7	4	0	5	0	0.72	0.85
521	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(1), HS3ST2(3), XYLT1(2), XYLT2(1)	1152396	8	4	8	1	4	1	0	1	2	0	0.72	0.85
522	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(1), HS3ST2(3), XYLT1(2), XYLT2(1)	1152396	8	4	8	1	4	1	0	1	2	0	0.72	0.85
523	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP2(1), ACPP(2), ALPPL2(1), CYP3A43(2), CYP3A7(3), DHRS1(1), DHRS2(1), DHRS3(1), PON1(1), PON2(1)	3151444	14	9	14	7	6	4	2	0	1	1	0.74	0.87
524	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ALG6(1), CCKBR(4), CCR3(2), CCR5(1), CELSR1(1), CELSR2(2), CELSR3(1), CHRM2(3), EDNRA(1), EMR2(5), EMR3(2), FSHR(2), GHRHR(1), GPR116(6), GPR133(2), GPR17(1), GPR18(2), GPR56(1), GPR77(1), GPR84(4), GRM1(5), GRPR(1), HRH4(1), LPHN2(5), LPHN3(7), PTGFR(3), SMO(1), SSTR2(1), TAAR5(2), TSHR(4)	11723154	73	28	73	35	25	22	19	1	6	0	0.74	0.87
525	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(1), JAK1(1), STAT1(1), STAT2(4)	1965566	7	5	7	3	3	2	1	0	1	0	0.74	0.87
526	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(3), CREBBP(8), DLL1(3), DLL3(1), DLL4(1), DTX1(3), DTX2(2), DTX3(1), DVL2(2), DVL3(2), EP300(8), HDAC1(2), JAG1(2), MAML1(3), NCSTN(1), NOTCH2(6), NOTCH3(5), NOTCH4(6), PTCRA(1), RBPJ(5), SNW1(2)	11787028	67	28	67	19	24	23	9	1	10	0	0.74	0.87
527	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(1), BAIAP2(1), CASP3(1), CASP7(1), CASP8(5), INSR(1), ITCH(1), MAGI1(6), MAGI2(7), WWP1(3)	4271616	27	13	27	7	9	6	8	0	4	0	0.75	0.88
528	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIT1(2), CMAS(3), CTBS(1), CYB5R1(2), GFPT1(3), GFPT2(1), HEXB(2), HK1(2), HK3(1), LHPP(1), MTMR1(2), MTMR2(1), NAGK(1), NANS(1), NPL(2), PGM3(2), PHPT1(1)	5233978	28	16	28	10	12	8	5	1	2	0	0.75	0.88
529	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), B4GALT1(2), G6PC(1), G6PC2(1), GALK2(2), GALT(1), GANC(1), GCK(1), GLA(1), HK1(2), HK3(1), LALBA(1), LCT(11), MGAM(4), PFKM(3), PFKP(2), PGM1(3), PGM3(2), RDH11(1), RDH12(2), UGP2(3)	6960784	46	21	46	10	17	18	9	0	2	0	0.75	0.88
530	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), CD38(2), ENPP3(2), NADSYN1(1), NMNAT1(1), NMNAT2(1), NNMT(3), NNT(3), NT5E(1)	2681092	17	8	17	8	4	7	3	0	3	0	0.76	0.88
531	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(1), CCR3(2), CCR4(1), CCR5(1), CCR7(2), CD28(1), CXCR4(1), IFNGR1(1), IFNGR2(1), IL12A(1), IL12B(1), IL12RB2(2), IL18R1(4), IL2(2), IL4(1), TGFB1(1), TGFB2(4)	3652448	27	10	27	9	5	13	5	0	4	0	0.76	0.88
532	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(3), CLOCK(3), CRY1(3)	1554740	9	4	9	2	1	3	2	0	2	1	0.77	0.89
533	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(3), CLOCK(3), CRY1(3), CSNK1D(2), NPAS2(1), PER2(1), PER3(3)	3098420	16	9	16	2	3	5	4	0	3	1	0.77	0.89
534	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	59	B3GALNT1(2), B3GALT4(1), B3GALT5(2), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALNT1(2), B4GALT1(2), B4GALT3(3), B4GALT6(2), FUT1(3), FUT3(2), FUT9(2), GCNT2(4), PIGA(1), PIGB(1), PIGG(3), PIGK(3), PIGM(3), PIGN(1), PIGO(1), PIGQ(1), PIGS(1), PIGT(2), PIGU(1), PIGV(2), PIGX(2), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1), ST3GAL6(4), ST6GALNAC3(1), ST6GALNAC4(2), ST6GALNAC5(3), ST8SIA5(2), UGCG(1)	8682400	68	24	68	19	27	22	14	1	4	0	0.77	0.89
535	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(3), GPD2(1), SDHA(1)	1189436	5	4	5	0	1	1	3	0	0	0	0.78	0.89
536	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(4), IKBKB(2), IL1B(1), IL1R1(1), IL1RAP(1), IL1RN(2), IL6(2), IRAK3(2), MAP2K3(4), MAP2K6(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MAPK8(6), MYD88(1), NFKB1(4), TGFB1(1), TGFB2(4), TOLLIP(1), TRAF6(1)	5370700	43	14	43	10	16	12	9	2	4	0	0.78	0.89
537	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACADL(2), ACADM(4), ACOX2(1), ACOX3(3), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(2), ADIPOQ(2), CPT1A(3), CPT1B(1), CPT2(2), CYP27A1(1), CYP4A11(2), CYP4A22(1), CYP7A1(1), CYP8B1(1), FABP1(1), FABP2(1), FABP3(1), FABP7(1), FADS2(1), GK(1), GK2(5), HMGCS2(1), LPL(2), ME1(3), MMP1(1), NR1H3(2), OLR1(1), PCK1(3), PCK2(2), PDPK1(1), PLTP(3), PPARA(1), PPARD(1), PPARG(1), RXRB(1), RXRG(2), SCD(1), SCP2(1), SLC27A2(1), SLC27A4(1), SLC27A5(1), SLC27A6(5), SORBS1(7), UCP1(1)	11751216	84	26	84	25	28	28	17	3	8	0	0.78	0.89
538	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	CA1(1), CA3(1), CA5A(2), CA8(1), CPS1(7), CTH(1), GLUD2(3), GLUL(2), HAL(1)	3851292	19	10	19	11	5	9	2	0	3	0	0.78	0.89
539	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	HMGCL(1)	618174	1	1	1	2	1	0	0	0	0	0	0.78	0.89
540	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ASAH1(1), B4GALT6(2), CERK(1), DEGS1(1), ENPP7(1), GAL3ST1(2), GLA(1), LCT(11), NEU1(1), SGMS1(1), SGMS2(2), SGPP1(2), SGPP2(3), SMPD3(1), SPHK1(1), SPTLC1(1), UGCG(1), UGT8(3)	6189214	37	17	36	12	14	10	9	0	3	1	0.78	0.89
541	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), IL12A(1), IL12B(1), IL12RB2(2), JAK2(4), STAT4(3)	2711230	12	7	12	3	0	5	5	0	1	1	0.78	0.89
542	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(4), ALDH1A1(1), ALDH1A2(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH4A1(1), AMD1(1), AOC2(1), AOC3(1), ARG2(2), ASL(2), CKM(1), CKMT2(3), CPS1(7), DAO(4), GOT1(2), MAOA(3), MAOB(1), NOS1(6), OAT(1), ODC1(4), OTC(2), P4HA1(1), P4HA3(1), RARS(3)	7915616	64	22	63	25	26	20	7	1	10	0	0.78	0.89
543	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(3), CR2(3), HLA-DRA(3), HLA-DRB1(1), ITGAL(4), ITGB2(2), PTPRC(9)	2709092	26	9	26	8	5	14	4	0	3	0	0.79	0.89
544	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(2), ALDOC(2), FBP2(1), GOT1(2), GPT2(1), ME1(3), ME3(3), PGK1(1), TKT(1)	3217240	16	11	16	12	9	4	2	0	1	0	0.79	0.89
545	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(2), ACTN2(5), ACTN3(1), ITGA1(1), ITGB3(2), PTK2(1), SPTAN1(7), SRC(3), TLN1(3)	5326934	26	17	26	14	12	11	1	0	2	0	0.79	0.89
546	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), AARS2(1), ABAT(1), ADSL(2), ADSS(1), ASL(2), ASPA(2), ASS1(1), CAD(4), CRAT(2), DARS(3), DARS2(1), DLAT(1), DLD(1), GAD1(2), GAD2(2), GOT1(2), GPT2(1), NARS(2), NARS2(3), PC(4), PDHA1(1), PDHA2(4)	6919520	45	21	45	21	22	12	9	0	2	0	0.79	0.89
547	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ARG2(2), ASL(2), CKM(1), CKMT2(3), CPS1(7), NAGS(1), OAT(1), ODC1(4), OTC(2)	3153684	24	9	24	9	8	7	4	0	5	0	0.80	0.90
548	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(2), CAMK1G(3), CAMK2D(2), CAMK4(1), ESRRA(1), HDAC5(1), MEF2A(1), MEF2C(2), PPARA(1), PPP3CA(2), PPP3CB(2), PPP3CC(3), SLC2A4(2), YWHAH(1)	3824840	24	10	24	10	8	7	4	0	5	0	0.80	0.90
549	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACAA2(1), ACADL(2), ACADM(4), ACADVL(1), ACOX3(3), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(2), ADH1A(1), ADH1B(2), ADH1C(1), ADH4(2), ADH6(2), ADH7(1), ADHFE1(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH7A1(2), CPT1A(3), CPT1B(1), CPT2(2), CYP4A11(2), CYP4A22(1), ECHS1(1), GCDH(3), HADH(1), HADHA(1), HADHB(1), HSD17B10(1), HSD17B4(1)	8939832	58	21	58	24	17	18	14	1	8	0	0.80	0.90
550	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(3), CAMK2D(2), CAMK4(1), CAMKK1(1)	2126238	9	5	9	5	1	5	2	0	1	0	0.81	0.91
551	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(1), ALAS2(3), FECH(1), GATA1(1), HBB(2), UROD(1)	1505294	10	6	10	4	5	5	0	0	0	0	0.81	0.91
552	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ6(1), NDUFA12(1)	763446	3	2	3	2	0	1	1	0	1	0	0.82	0.91
553	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(1), PAPSS2(2), SULT1A2(1), SULT1E1(1), SULT2A1(1), SUOX(1)	1110132	7	3	7	0	1	4	1	0	1	0	0.82	0.91
554	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	SHMT1(1), SHMT2(1)	779356	2	2	2	1	1	1	0	0	0	0	0.82	0.91
555	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	FOS(1), GRB2(2), JAK2(4), MAP2K1(2), MAPK3(1), MAPK8(6), PLCG1(1), RAF1(4), SHC1(1), SOS1(3), STAT5B(1)	3958936	26	11	26	5	6	8	7	1	3	1	0.82	0.91
556	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD58(1), IL3(1), IL6(2), IL8(1), KITLG(1)	1162154	6	4	6	2	3	2	1	0	0	0	0.82	0.91
557	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(2), HEXB(2), LCT(11), SLC33A1(1), ST3GAL2(1), ST6GALNAC3(1), ST6GALNAC4(2), ST6GALNAC5(3), ST8SIA5(2)	3002624	26	12	26	7	10	10	6	0	0	0	0.82	0.91
558	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(1), BTK(2), EEA1(4), GSK3B(2), PDPK1(1), PFKM(3), PFKP(2), PLCG1(1), PRKCE(2), VAV2(3)	4612148	22	12	22	11	5	11	4	0	2	0	0.83	0.91
559	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(4), EGFR(5), GRB2(2), MET(1), PDGFRA(4), PRKCA(3), SH3GLB1(1), SH3GLB2(2), SH3KBP1(1), SRC(3)	3588918	26	11	26	15	10	13	3	0	0	0	0.83	0.91
560	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(1)	561990	2	2	2	0	1	1	0	0	0	0	0.83	0.91
561	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(2), AASDHPPT(1), AASS(2), ALDH1A1(1), ALDH1A2(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), BBOX1(2), DLST(1), ECHS1(1), EHMT2(3), GCDH(3), HADHA(1), PLOD1(2), PLOD2(1), PLOD3(1), SDS(1), SHMT1(1), SHMT2(1), TMLHE(2)	6462688	39	18	39	11	16	11	5	0	7	0	0.83	0.91
562	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(1), ARSD(1), ASAH1(1), GAL3ST1(2), GLA(1), LCT(11), NEU1(1), SPTLC1(1), UGCG(1)	4217276	20	14	20	7	8	6	4	0	2	0	0.83	0.91
563	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(1), DLD(1), DLST(1), IDH2(1), IDH3A(3), OGDH(2), PC(4), PDHA1(1), PDHA2(4), PDK1(2), PDK2(1), PDK3(1), PDK4(2), PDP2(1), SDHA(1), SUCLA2(3), SUCLG1(1)	5241028	30	14	30	15	10	9	7	0	4	0	0.84	0.92
564	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(2), CARM1(1), CREBBP(8), EP300(8), ERCC3(3), ESR1(3), GRIP1(1), GTF2A1(1), GTF2E1(2), GTF2F1(3), HDAC1(2), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(2), MEF2C(2), NR0B1(1), NRIP1(2), POLR2A(1)	8632998	47	21	47	14	15	18	7	3	4	0	0.85	0.92
565	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), LPO(1), MPO(2), TPO(4)	1547618	8	6	8	5	5	3	0	0	0	0	0.85	0.93
566	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX3(3), ELOVL2(1), FADS2(1), HADHA(1), SCD(1)	2303654	8	8	8	7	4	2	1	0	1	0	0.86	0.93
567	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(2), FUCA1(2), HEXB(2), LCT(11), MAN2B1(1), MANBA(5), NEU1(1)	3602944	24	12	24	8	8	7	6	0	3	0	0.86	0.93
568	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(2), APOBEC3F(1), APOBEC3G(1), APOBEC4(3)	1346156	7	4	7	2	2	3	2	0	0	0	0.86	0.93
569	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(5), POLR2A(1), POLR2B(3), POLR2D(1), POLR2K(1)	2351498	11	6	11	1	4	3	4	0	0	0	0.87	0.94
570	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1B2(1), EEF2K(1), EIF2AK1(2), EIF2AK2(1), EIF2AK3(1), EIF2B2(1), EIF2B5(3), EIF4A2(1), EIF4EBP2(1), EIF4G1(3), EIF4G3(7), EIF5(1), EIF5A(1), ETF1(3), PABPC3(2), PAIP1(3), SLC35A4(1)	8012956	33	20	33	8	8	12	7	1	5	0	0.87	0.94
571	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(4), PGAP1(4), PIGA(1), PIGB(1), PIGG(3), PIGK(3), PIGM(3), PIGN(1), PIGO(1), PIGQ(1), PIGS(1), PIGT(2), PIGU(1), PIGV(2), PIGX(2)	4513848	30	12	29	8	9	12	6	0	3	0	0.88	0.95
572	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(1), CHST12(1), CHST13(1), PAPSS1(1), PAPSS2(2), SULT1A2(1), SULT1E1(1), SULT2A1(1), SUOX(1)	1634172	10	5	10	2	2	5	2	0	1	0	0.89	0.96
573	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CSNK1D(2), GSK3B(2), MAPT(1), PPP2CA(1)	1715162	7	5	7	4	4	1	2	0	0	0	0.89	0.96
574	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(4), DUSP1(2), IKBKAP(1), IKBKB(2), MAP3K1(2), MAP3K14(1), NFKB1(4), TANK(3), TNFAIP3(1), TRAF1(1), TRAF3(2)	4167600	23	11	23	8	9	7	6	0	1	0	0.89	0.96
575	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(1), MBTPS1(5), SCAP(1)	2084080	7	3	7	6	3	3	0	0	1	0	0.89	0.96
576	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), AADAC(1), ABAT(1), ACSM1(3), ALDH1A3(4), ALDH1B1(2), ALDH2(2), ALDH3A2(1), ALDH5A1(2), ALDH7A1(2), BDH1(1), DDHD1(2), ECHS1(1), GAD1(2), GAD2(2), HADH(1), HADHA(1), HMGCL(1), HMGCS2(1), HSD17B10(1), HSD17B4(1), PDHA1(1), PDHA2(4), RDH11(1), RDH12(2)	7481738	41	19	41	22	17	12	7	0	5	0	0.90	0.96
577	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1), RAB3A(1), RAB9A(1)	793924	4	2	4	0	2	1	0	0	1	0	0.90	0.96
578	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(3), EPHB1(3), FYN(1), ITGA1(1), L1CAM(2), RAP1B(1), SELP(2)	2882654	14	8	14	9	6	4	3	0	1	0	0.90	0.96
579	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(1), CDC40(2), CLK3(3), CLK4(2), COL2A1(2), CPSF1(1), CPSF2(1), CPSF3(2), CPSF4(1), CSTF1(1), CSTF2T(4), CSTF3(3), DDX1(2), DDX20(1), DHX15(2), DHX16(3), DHX38(4), DHX8(3), DHX9(1), DICER1(1), LSM2(1), METTL3(1), NCBP1(3), NCBP2(1), NONO(1), NXF1(3), PAPOLA(3), PHF5A(1), POLR2A(1), PPM1G(1), PRPF18(2), PRPF3(1), PRPF4B(7), PRPF8(3), PTBP2(1), RBM17(1), RBM5(2), RNGTT(1), RNMT(2), RNPS1(1), SF3A1(1), SF3B1(3), SFRS14(2), SFRS4(2), SNRPA(1), SNRPB(1), SNRPB2(1), SNRPD3(1), SPOP(1), SRPK1(2), SRPK2(3), SRRM1(5), SUPT5H(5), U2AF1(1), U2AF2(1), XRN2(3)	19105370	110	32	110	20	34	39	27	1	9	0	0.91	0.97
580	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	BDH1(1), HMGCL(1), HMGCS2(1)	1317242	3	3	3	4	3	0	0	0	0	0	0.91	0.97
581	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN2(2), EGFR(5), ITGA1(1), MAPK3(1), MYLK(5), PRKACG(1), PRKAR1A(4), PRKAR1B(1), PRKAR2B(1), PTK2(1), TLN1(3)	6115308	26	16	26	12	10	9	4	0	3	0	0.92	0.97
582	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1), NR1H3(2), NR1H4(1)	970682	4	3	4	2	2	1	1	0	0	0	0.92	0.97
583	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR2(1), MAPK8(6), NFKB1(4), TNFRSF11A(1), TRAF6(1)	1981256	15	6	15	5	7	5	2	1	0	0	0.92	0.97
584	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	SHMT1(1), SHMT2(1)	1046612	2	2	2	2	1	1	0	0	0	0	0.92	0.97
585	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOB(2), ALDOC(2), FBP2(1), FPGT(2), GCK(1), GMPPA(4), HK1(2), HK3(1), KHK(1), PFKFB1(2), PFKM(3), PFKP(2), PMM1(2), SORD(2)	4427774	28	14	28	10	10	13	4	0	1	0	0.92	0.97
586	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(8), APOC1(1), APOC2(1), CETP(4), CYP7A1(1), HMGCR(1), LCAT(1), LDLR(1), LIPC(1), LPL(2), LRP1(7), SCARB1(1)	4802826	29	13	29	7	13	9	4	0	3	0	0.93	0.97
587	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(4), IKBKB(2), IL2(2), IL4(1), MAP3K1(2), MAP3K5(3), MAPK8(6), NFKB1(4), TNFRSF9(2)	3623958	27	10	27	6	7	12	7	1	0	0	0.93	0.97
588	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(2), ARSB(1), FUCA1(2), GALNS(1), GNS(3), GUSB(1), HEXB(2), HPSE2(3), LCT(11), MAN2B1(1), MANBA(5), NAGLU(2), NEU1(1), SPAM1(4)	6210066	39	16	39	12	14	11	8	1	5	0	0.93	0.98
589	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(1), FOS(1), FYN(1), THBS1(3)	1333260	6	3	6	1	3	2	1	0	0	0	0.94	0.98
590	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPPL2(1), ASCC3(8), DDX18(1), DDX19A(1), DDX23(1), DDX4(1), DDX50(1), DDX52(1), DDX55(2), DDX56(2), DHFR(1), DHX58(1), EP400(7), ERCC2(2), ERCC3(3), IFIH1(2), MOV10L1(7), RAD54B(3), RAD54L(1), SETX(10), SKIV2L2(2), SMARCA2(2), SMARCA5(4)	11476448	64	24	64	20	18	20	15	0	11	0	0.94	0.98
591	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(1), IL8(1), NFKB1(4), XDH(1)	1793564	7	4	7	3	4	1	2	0	0	0	0.94	0.98
592	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR2(1), ACTR3(1), ARPC1B(1), ARPC2(1), CDC42(1), WASF1(2), WASL(2)	1505656	10	3	10	1	5	1	2	0	2	0	0.94	0.98
593	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	CA1(1), CA3(1), CA5A(2), CA8(1), CPS1(7), CTH(1), GLUL(2), HAL(1)	3445382	16	7	16	10	5	7	1	0	3	0	0.95	0.98
594	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ANKRD1(3), IFRD1(3), IL1R1(1), MYOG(1), NR4A3(2)	1982408	10	4	10	1	4	3	2	0	1	0	0.95	0.98
595	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH11(1), RDH12(2)	877272	3	2	3	2	1	2	0	0	0	0	0.95	0.98
596	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT3(1), CHPF(1), CHST11(1), CHST12(1), CHST13(1), CHSY1(1), DSE(1), XYLT1(2), XYLT2(1)	2473008	10	6	10	6	3	3	2	0	2	0	0.96	0.99
597	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(3), GCK(1), GFPT1(3), HEXB(2), HK1(2), HK3(1), PGM3(2)	3108130	14	7	14	3	3	8	3	0	0	0	0.96	0.99
598	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), SQLE(1)	616016	2	1	2	2	0	1	1	0	0	0	0.96	0.99
599	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(3), GTF2A1(1), GTF2E1(2), GTF2F1(3), HDAC3(1), NCOA1(3), NCOA2(3), NCOA3(5), POLR2A(1)	4556784	22	12	22	8	7	8	5	0	2	0	0.96	0.99
600	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(1), IL1B(1)	1055922	2	2	2	3	2	0	0	0	0	0	0.96	0.99
601	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(2), ALDOC(2), DLAT(1), DLD(1), ENO2(2), ENO3(2), FBP2(1), G6PC(1), GCK(1), GOT1(2), GPI(1), HK1(2), HK3(1), LDHA(2), LDHAL6B(1), LDHB(2), LDHC(1), PC(4), PCK1(3), PDHA1(1), PDHA2(4), PFKM(3), PFKP(2), PGK1(1), PGK2(1), TNFAIP1(1)	7611248	45	18	45	23	16	16	9	0	4	0	0.96	0.99
602	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(3), PRKACG(1), PRKAR2B(1)	1848722	5	4	5	4	2	2	0	0	1	0	0.97	0.99
603	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(1), HMGCR(1), LSS(1), NQO2(1), SC5DL(2), SQLE(1)	2025878	8	5	8	4	4	1	3	0	0	0	0.97	0.99
604	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	AGT(2), AGTR1(3), AGTR2(1), BDKRB2(1), KNG1(1), REN(2)	1723428	10	4	10	5	2	5	1	0	2	0	0.97	0.99
605	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPL13(1), RPL10A(1), RPL11(1), RPL19(1), RPL28(1), RPL6(2), RPL9(2), RPS15A(1), RPS16(1), RPS18(1), RPS2(1), RPS3(1), RPS9(1)	3969530	16	9	16	4	1	5	8	1	1	0	0.97	0.99
606	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(2), UBE2C(1), UBE2D3(1), UBE2I(1), UBE3A(5)	1894288	10	3	10	4	2	4	3	0	1	0	0.98	0.99
607	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), DHCR24(1), DHCR7(1), EBP(1), FDFT1(1), GGCX(3), GGPS1(1), HMGCR(1), LSS(1), NSDHL(1), SC4MOL(1), SC5DL(2), SQLE(1)	3541322	16	9	16	9	6	8	2	0	0	0	0.98	0.99
608	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGFR(5), MAP2K1(2), MAP3K1(2), THRB(1)	3103340	10	7	10	4	4	4	2	0	0	0	0.98	1.00
609	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), ALDOB(2), ALDOC(2), FBP2(1), FPGT(2), GMPPA(4), HK1(2), HK3(1), KHK(1), LHPP(1), MTMR1(2), MTMR2(1), PFKFB1(2), PFKM(3), PFKP(2), PHPT1(1), PMM1(2), RDH11(1), RDH12(2), SORD(2)	6831016	35	15	35	17	14	15	4	0	2	0	0.99	1.00
610	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDFT1(1), HMGCR(1), LSS(1), NSDHL(1), SC4MOL(1), SC5DL(2), SQLE(1)	2424840	9	5	9	6	4	3	2	0	0	0	0.99	1.00
611	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	CHUK(4), IKBKB(2), IL1R1(1), MAP3K1(2), MAP3K14(1), MAP3K7(2), MYD88(1), NFKB1(4), TLR4(4), TNFAIP3(1), TRAF6(1)	4416028	23	9	23	7	8	7	7	0	1	0	0.99	1.00
612	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), GGPS1(1), SQLE(1)	813046	3	1	3	4	0	2	1	0	0	0	0.99	1.00
613	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPPL2(1), DHFR(1)	1122448	2	2	2	0	0	2	0	0	0	0	1.00	1.00
614	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), OAT(1)	1004610	2	1	2	1	1	0	1	0	0	0	1.00	1.00
615	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		92476	0	0	0	0	0	0	0	0	0	0	1.00	1.00
616	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		213324	0	0	0	0	0	0	0	0	0	0	1.00	1.00