rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(4), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(2), ANAPC7(1), CDC16(2), CDC20(1), CDC23(2), CDC27(5), CUL1(3), CUL2(1), CUL3(2), FBXW11(1), FBXW7(4), FZR1(1), SKP2(1), SMURF1(1), SMURF2(2), TCEB1(2), UBA1(1), UBE2D1(2), UBE2D2(1), UBE2D3(1), UBE2E2(1), VHL(149), WWP1(1), WWP2(1) 17820449 196 165 142 23 4 19 31 46 96 0 0.00022 <1.00e-15 <2.05e-13 2 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF1(1), EIF2B1(2), EIF2B2(1), EIF2B5(2), EIF2S1(1), EIF2S2(1), ELAVL1(1), FLT1(3), FLT4(4), HIF1A(3), KDR(5), NOS3(1), PIK3CA(14), PIK3R1(1), PTK2(1), PXN(2), SHC1(2), VHL(149) 14983008 194 165 139 19 7 18 26 51 92 0 0.000033 <1.00e-15 <2.05e-13 3 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(1), EP300(6), HIF1A(3), JUN(1), NOS3(1), VHL(149) 7504580 161 150 107 10 2 15 18 37 89 0 2.89e-06 <1.00e-15 <2.05e-13 4 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(1), AKT2(2), AKT3(2), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(14), PIK3CD(1), PTEN(16), PTK2B(2), RBL2(3), SHC1(2), SOS1(4) 8973555 50 45 49 5 3 5 19 14 9 0 0.0012 3.27e-06 0.00050 5 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(1), AKT2(2), AKT3(2), CDKN1A(1), ELK1(1), MAP2K1(1), NGFR(1), NTRK1(2), PIK3CA(14), PIK3CD(1), SHC1(2), SOS1(4) 7184719 32 31 31 2 2 3 13 13 1 0 0.0029 0.00014 0.017 6 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(3), GOT1(2), GOT2(3), TAT(1), TYR(1) 2063429 10 10 10 1 1 0 5 1 3 0 0.21 0.00085 0.088 7 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(11), CR2(1), HLA-DRA(1), ITGAL(3), ITGB2(1), PTPRC(6) 6737962 24 23 21 2 2 0 2 12 8 0 0.080 0.0025 0.22 8 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(2), CTH(1), GOT1(2), GOT2(3), LDHB(1), LDHC(2), MPST(2) 3003190 13 13 13 2 2 0 4 3 4 0 0.33 0.0049 0.38 9 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(2), CARS2(3), CTH(1), GOT1(2), GOT2(3), LDHAL6B(1), LDHB(1), LDHC(2), MPST(2), SULT1C2(1), SULT4A1(1) 5521164 19 19 19 2 2 1 5 5 6 0 0.14 0.0067 0.41 10 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(2), NR1I3(1), PTGS2(4) 2332448 9 9 9 1 1 0 1 5 2 0 0.35 0.0072 0.41 11 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(3), ATG7(4), BECN1(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), PIK3C3(4), PIK3R4(7), PRKAA1(1), ULK1(1), ULK2(2), ULK3(2) 9349525 33 32 33 4 3 1 5 17 7 0 0.077 0.0073 0.41 12 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), CPS1(5), GLS(1), GLUD1(2), GOT1(2) 3418789 11 11 11 1 0 0 6 2 3 0 0.16 0.0080 0.41 13 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), GOT2(3), TAT(1) 1153972 6 6 6 1 1 0 3 0 2 0 0.42 0.0086 0.41 14 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), FARSB(1), GOT1(2), GOT2(3), PAH(3), TAT(1), YARS(1) 3828103 12 12 12 1 1 0 3 5 3 0 0.18 0.013 0.58 15 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), GOT1(2), GOT2(3), PAH(3), TAT(1), YARS(1) 3637448 11 11 11 1 1 0 3 4 3 0 0.21 0.020 0.84 16 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ5(2), COQ6(1), NDUFA13(3), NDUFB11(1) 1778759 7 7 7 0 2 0 1 3 1 0 0.15 0.024 0.93 17 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(2), GGT1(1), SHMT1(2), SHMT2(2) 1851827 7 7 7 1 0 0 3 1 3 0 0.38 0.032 1.00 18 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(2), FMOD(2), LUM(2) 1589276 6 6 6 0 0 0 3 2 1 0 0.15 0.033 1.00 19 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(1), EIF2B5(2), EIF2S1(1), EIF2S2(1), EIF4E(1), GSK3B(1), IGF1(1), IGF1R(1), INPPL1(1), PDK2(1), PIK3CA(14), PIK3R1(1), PPP2CA(1), PTEN(16), RPS6KB1(2) 8676039 45 40 44 9 0 4 16 16 9 0 0.065 0.038 1.00 20 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(5), EGF(3), EGFR(4), HGS(3), TF(1), TFRC(2) 5644686 18 18 18 2 2 2 6 5 3 0 0.10 0.050 1.00 21 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(4), PDXP(1), PSAT1(2) 2127752 7 7 7 0 2 0 0 3 2 0 0.11 0.051 1.00 22 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(2), AASDHPPT(1), AASS(5) 3060096 9 9 9 2 0 1 1 3 4 0 0.68 0.056 1.00 23 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTR2(2), ACTR3(1), ARPC2(1), ARPC3(1), CDC42(2), WASF1(2), WASL(5) 3565740 14 13 14 2 0 3 4 7 0 0 0.17 0.062 1.00 24 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(2), EPX(1), MPO(2), PRDX1(1), PRDX5(1), PRDX6(1), SHMT1(2), SHMT2(2), TPO(2) 5198189 15 15 15 1 1 2 5 5 2 0 0.056 0.063 1.00 25 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(3), EGFR(4), ERBB3(5), NRG1(2), UBE2D1(2) 4519374 16 16 16 3 2 1 7 1 5 0 0.24 0.066 1.00 26 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(1), AASS(5) 2077732 7 7 7 2 0 1 0 3 3 0 0.79 0.069 1.00 27 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(3), MTMR2(1), MTMR6(2), NFS1(2) 2827611 8 8 8 1 1 0 2 3 2 0 0.26 0.069 1.00 28 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(1), ALPP(3), ALPPL2(1), DHFR(1), FPGS(1), GGH(1) 2902656 10 8 10 1 1 1 1 6 1 0 0.22 0.077 1.00 29 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(1), CD3G(1), CD4(1), FYN(1), HLA-DRA(1), PTPRC(6), ZAP70(2) 3990851 13 11 13 0 1 2 0 8 2 0 0.080 0.079 1.00 30 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(6), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAR2B(2) 4423565 12 12 12 0 2 1 4 5 0 0 0.026 0.084 1.00 31 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(2), EPX(1), MPO(2), MTHFR(1), PRDX6(1), SHMT1(2), SHMT2(2), TPO(2) 5115216 14 14 14 1 1 1 5 5 2 0 0.075 0.087 1.00 32 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(2), CD4(1), HLA-DRA(1) 1044308 4 4 4 0 1 1 0 1 1 0 0.42 0.11 1.00 33 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD34(2), CD3E(1), CD3G(1), CD4(1), IL3(1), KITLG(2) 2739311 8 8 8 1 1 1 0 6 0 0 0.43 0.11 1.00 34 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR1B(1), BMPR2(4) 2758419 6 6 6 1 0 0 2 3 1 0 0.44 0.12 1.00 35 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(1), SRP19(1), SRP54(1), SRP68(3), SRP72(1), SRP9(1) 3292285 9 9 9 1 0 1 5 3 0 0 0.18 0.12 1.00 36 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), GLI2(3), GLI3(4), GSK3B(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), SHH(1), SMO(3) 7359531 20 19 20 2 5 1 4 10 0 0 0.049 0.12 1.00 37 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(2), CD3E(1), CD3G(1), CD4(1) 1411493 5 5 5 0 1 2 0 2 0 0 0.25 0.13 1.00 38 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(1), AKT2(2), AKT3(2), CDKN2A(3), DAPP1(1), GSK3A(1), GSK3B(1), IARS(2), INPP5D(1), PDK1(1), PIK3CA(14), PPP1R13B(3), PTEN(16), RPS6KA1(2), RPS6KA2(1), RPS6KB1(2), SHC1(2), SOS1(4), SOS2(1), TEC(3), YWHAE(2) 15940631 66 57 65 11 4 5 22 22 13 0 0.016 0.14 1.00 39 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(2), CD4(1), CD80(1), HLA-DRA(1) 1747283 5 5 5 0 1 1 0 2 1 0 0.36 0.14 1.00 40 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(3), EPHX2(1), RDH11(2) 2127755 6 6 6 1 1 1 1 3 0 0 0.45 0.15 1.00 41 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(1), GBA3(2), MPO(2), PRDX1(1), PRDX5(1), PRDX6(1), TPO(2), TYR(1) 4242452 11 11 11 0 1 2 5 2 1 0 0.028 0.15 1.00 42 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2B(1), UBE2D1(2), UBE2D2(1), UBE2D3(1), UBE2H(2), UBE2J1(1), UBE2J2(1), UBE3A(1) 4626924 11 11 11 1 1 0 3 4 3 0 0.19 0.16 1.00 43 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 FYN(1), JUN(1), MAPK14(1), THBS1(5) 3236577 8 8 8 1 0 0 2 6 0 0 0.45 0.16 1.00 44 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(2), SNAP25(1) 1429502 3 3 3 1 1 0 0 0 2 0 0.67 0.20 1.00 45 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(2), CD3E(1), CD3G(1), CD4(1), ITGAL(3), ITGB2(1), PTPRC(6) 4967899 15 14 15 2 2 2 1 9 1 0 0.27 0.22 1.00 46 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), HDAC9(2), MEF2A(2), MEF2C(2), MEF2D(1) 3527673 8 8 8 0 1 1 1 3 2 0 0.17 0.23 1.00 47 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), DHFR(1), HPRT1(1), IMPDH1(2), MTHFD2(1), POLB(2), POLD1(3), POLG(2), PRPS2(2), RRM1(1) 5540011 16 16 16 3 2 1 5 7 1 0 0.23 0.24 1.00 48 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 CDKN1A(1), GRIN1(2), HIF1A(3), JAK2(5), RELA(1), SOD2(1) 5582784 13 12 13 1 0 2 3 5 3 0 0.13 0.24 1.00 49 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1), CD3G(1) 499769 2 2 2 0 0 1 0 1 0 0 0.57 0.25 1.00 50 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 317555 1 1 1 0 0 0 1 0 0 0 0.65 0.26 1.00 51 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(2) 794120 2 2 2 0 0 0 1 1 0 0 0.53 0.26 1.00 52 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(2), CD3E(1), CD3G(1), ITGAL(3), ITGB2(1), PTPRC(6) 4731782 14 13 14 2 2 2 1 8 1 0 0.30 0.28 1.00 53 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(1), ST3GAL5(1), ST6GALNAC2(2), ST8SIA1(1) 2483358 6 6 6 1 0 0 1 5 0 0 0.51 0.28 1.00 54 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(9), ABCB11(2), ABCB4(1), ABCC1(3), ABCC3(1) 6319348 16 15 16 2 3 1 6 3 3 0 0.092 0.29 1.00 55 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB11A(1), RAB1A(1), RAB3A(1), RAB4A(1), RAB9A(1) 1886962 5 5 5 1 0 1 2 1 1 0 0.49 0.29 1.00 56 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(4), EP300(6), NCOA3(4), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), RARA(4) 9091041 24 24 24 4 2 2 8 11 1 0 0.11 0.29 1.00 57 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(1), JAK1(4), JAK2(5), STAT1(2) 3619489 12 11 12 3 1 1 2 4 4 0 0.58 0.30 1.00 58 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(1), LCMT1(1), LCMT2(2), METTL6(1), PCYT1B(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(1) 6232199 15 14 15 1 1 2 4 7 1 0 0.094 0.31 1.00 59 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD1(1), DRD2(1), GRM1(4), PLCB1(1), PPP1R1B(1), PPP2CA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2) 7058817 15 15 15 1 4 0 1 9 1 0 0.084 0.31 1.00 60 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP2(16), RANGAP1(1) 3693147 19 18 18 5 2 2 7 7 1 0 0.32 0.33 1.00 61 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1), CYP2C9(1) 883981 2 2 2 1 0 0 1 1 0 0 0.81 0.35 1.00 62 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), MIOX(2) 3770155 8 8 8 2 0 0 3 2 3 0 0.52 0.37 1.00 63 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 HBXIP(1), PTK2B(2), SHC1(2), SOS1(4), SRC(1) 3878392 10 10 10 2 1 0 6 3 0 0 0.35 0.37 1.00 64 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(2) 723135 2 2 2 1 0 1 1 0 0 0 0.79 0.37 1.00 65 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(1), GLUD1(2) 1992616 4 4 4 1 0 0 3 1 0 0 0.53 0.37 1.00 66 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(1), GH1(1), GHR(1), PIK3CA(14), PIK3R1(1), PPP2CA(1), RELA(1) 6184782 20 20 19 4 0 2 8 9 1 0 0.21 0.39 1.00 67 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(2), CALM2(1), CAMK1(1), CAMK2D(1), CAMK2G(2), CAMKK1(1), CAMKK2(1), SYT1(1) 5112305 10 10 10 0 1 0 3 5 1 0 0.083 0.40 1.00 68 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), GAD1(1), TPH1(3) 2673297 6 6 6 0 1 1 3 1 0 0 0.11 0.40 1.00 69 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 HGD(2) 984657 2 2 2 1 0 0 2 0 0 0 0.75 0.42 1.00 70 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(1), HS3ST3A1(1), XYLT1(1), XYLT2(2) 2928434 6 6 6 1 1 0 3 2 0 0 0.30 0.43 1.00 71 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(1), HS3ST3A1(1), XYLT1(1), XYLT2(2) 2928434 6 6 6 1 1 0 3 2 0 0 0.30 0.43 1.00 72 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), CDC25A(1), CDC25C(2), SHH(1), XPO1(5) 3843234 10 9 10 2 0 0 4 5 1 0 0.42 0.44 1.00 73 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CSAD(1), GAD1(1), GGT1(1) 2524757 5 5 5 1 1 0 2 1 1 0 0.46 0.44 1.00 74 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(4), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH7A1(2), ALDH9A1(1), AMDHD1(2), AOC2(1), AOC3(1), CNDP1(3), DDC(3), LCMT1(1), LCMT2(2), MAOA(1), MAOB(1), METTL6(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(1), PRPS1(1), PRPS2(2), UROC1(1) 17499134 42 35 42 5 2 2 16 17 5 0 0.011 0.45 1.00 75 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(1), EIF4A2(3), EIF4E(1), EIF4G1(5), EIF4G2(2), EIF4G3(3), MKNK1(1), PDK2(1), PIK3CA(14), PIK3R1(1), PPP2CA(1), PTEN(16), RPS6KB1(2), TSC1(4), TSC2(2) 12189748 57 48 56 10 1 6 17 22 11 0 0.022 0.46 1.00 76 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), CNR2(1), DNMT1(5), MTNR1B(1), PTGER2(1), PTGFR(1), PTGIR(1), TBXA2R(1) 4960822 12 12 12 2 2 1 3 5 1 0 0.25 0.46 1.00 77 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(1), EHHADH(2), HADHA(1) 2121564 4 4 4 0 1 0 3 0 0 0 0.20 0.47 1.00 78 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(1), NDUFA8(1), NDUFB6(1), NDUFS1(3), NDUFS2(1) 3056191 7 7 7 2 1 0 0 6 0 0 0.70 0.48 1.00 79 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPN1(1), CSNK1A1(1), GSK3B(1), MAPT(2), PPP2CA(1) 4150242 7 7 7 0 0 1 1 2 3 0 0.27 0.48 1.00 80 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 748011 1 1 1 1 0 0 0 1 0 0 0.94 0.49 1.00 81 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(1), GABRA3(1), GABRA4(3), GABRA5(2), GABRA6(1), PRKCE(4) 3483596 12 11 11 4 0 3 2 3 4 0 0.59 0.49 1.00 82 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ARG1(1), GLS(1), GLUD1(2) 2449544 4 4 4 0 0 0 3 0 1 0 0.30 0.50 1.00 83 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(2), F13B(2), HSD17B1(1), HSD17B4(1), HSD17B7(2), HSD3B1(1) 3583146 9 9 8 2 1 3 3 2 0 0 0.30 0.50 1.00 84 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(5), FH(1), IDH1(2), MDH1(2), SDHB(1) 3900866 11 11 11 3 1 1 3 5 1 0 0.52 0.54 1.00 85 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ECHS1(1), EHHADH(2), GCDH(1), HADHA(1), SDHB(1) 3424915 6 6 6 0 2 0 4 0 0 0 0.093 0.54 1.00 86 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(2), TGDS(1), UXS1(1) 1724726 5 5 5 2 0 0 2 3 0 0 0.80 0.54 1.00 87 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREM(1), JUN(1), MAPK3(1), POLR2A(5), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2) 5643102 14 13 14 2 4 1 4 4 1 0 0.14 0.54 1.00 88 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 HLA-DRA(1), IL3(1) 1331170 2 2 2 1 0 0 0 1 1 0 0.95 0.54 1.00 89 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLD1(3), POLD2(1), POLE(4), POLG(2), POLL(1), POLQ(6) 7332253 19 19 19 4 4 1 1 10 3 0 0.37 0.54 1.00 90 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(3), GALNS(1), GLB1(4), GNS(1), GUSB(2), HEXA(3), IDS(3), IDUA(1), LCT(1) 6313119 19 17 19 4 4 0 6 7 2 0 0.26 0.54 1.00 91 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(1), EHHADH(2), HADH(1), HADHA(1), HSD17B4(1), SIRT1(2), SIRT7(1), VNN2(2) 5218328 11 11 11 2 1 2 5 2 1 0 0.22 0.57 1.00 92 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(1), BCAR1(2), ITGB1(2), MAPK1(1), MAPK3(1), PDK2(1), PIK3CA(14), PIK3R1(1), PTEN(16), PTK2(1), SHC1(2), SOS1(4) 8522305 46 41 45 10 2 4 16 15 9 0 0.10 0.57 1.00 93 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), ENO1(1), GPI(1), PFKL(2), PGAM1(1), PGK1(2), TPI1(2) 4093113 10 9 10 3 1 1 3 4 1 0 0.57 0.57 1.00 94 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(2), JAK1(4), JAK2(5), TYK2(3) 4613052 14 13 14 4 2 1 3 5 3 0 0.60 0.58 1.00 95 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL4R(2), JAK1(4), JAK2(5), TYK2(3) 4613052 14 13 14 4 2 1 3 5 3 0 0.60 0.58 1.00 96 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ACTR3(1), ARPC2(1), ARPC3(1), CDC42(2), PAK1(1), PDGFRA(6), PIK3CA(14), PIK3R1(1), WASL(5) 5877261 34 33 33 9 0 3 13 17 1 0 0.31 0.59 1.00 97 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 SPCS1(2) 1362474 2 2 2 1 0 0 1 1 0 0 0.81 0.60 1.00 98 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 LCMT1(1), LCMT2(2), METTL6(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(1) 6625297 13 12 13 0 1 1 4 6 1 0 0.031 0.60 1.00 99 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), EIF4E(1), FBL(1), LDHB(1), LDHC(2), MAPK14(1), NCL(2) 3896897 11 11 11 3 0 0 5 4 2 0 0.55 0.61 1.00 100 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDKN1A(1), CHEK1(1), NEK1(2) 3157229 5 5 5 1 0 0 2 2 1 0 0.56 0.62 1.00 101 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(4), AOC2(1), AOC3(1), CES1(2), ESD(1) 2662151 9 8 9 3 0 1 2 6 0 0 0.63 0.62 1.00 102 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IL15(1), IL16(5), IL3(1), LTA(1) 4377011 9 9 9 2 1 0 3 5 0 0 0.46 0.63 1.00 103 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 BHMT(2), CTH(1), DNMT1(5), DNMT3A(4), DNMT3B(1), MARS(2), MTR(1) 7682844 16 16 16 2 2 2 5 5 2 0 0.12 0.63 1.00 104 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1) 921741 1 1 1 1 0 0 0 1 0 0 0.94 0.64 1.00 105 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(3), GALNS(1), GLB1(4), GNS(1), GUSB(2), HEXA(3), HGSNAT(3), HPSE(1), HPSE2(1), HYAL2(1), IDS(3), IDUA(1), LCT(1), SPAM1(5) 9027117 30 26 30 5 6 1 9 12 2 0 0.083 0.65 1.00 106 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTR2(2), ACTR3(1), ARPC2(1), ARPC3(1), NCKAP1(2), NTRK1(2), WASF1(2), WASF2(1), WASF3(1), WASL(5) 6716710 18 16 18 4 0 3 6 9 0 0 0.29 0.65 1.00 107 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(3), ARHGDIB(1), CASP1(1), CASP10(2), JUN(1) 5660688 9 9 9 2 0 0 2 4 3 0 0.71 0.65 1.00 108 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX3(3), ELOVL2(1), ELOVL5(1), FADS2(2), FASN(3), HADHA(1), PECR(2) 6310952 13 12 13 2 3 2 4 4 0 0 0.15 0.66 1.00 109 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(4), ANKRD1(2), DUSP14(1), EIF4E(1), HBEGF(1), IFRD1(2), NR4A3(2), WDR1(1) 4786872 14 14 14 4 0 1 6 4 3 0 0.54 0.67 1.00 110 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(4), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(1), DDC(3), EPX(1), GOT1(2), GOT2(3), HPD(1), MAOA(1), MAOB(1), MPO(2), PRDX1(1), PRDX5(1), PRDX6(1), TAT(1), TPO(2) 9685729 29 25 29 5 2 3 12 9 3 0 0.081 0.67 1.00 111 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), B3GNT1(1), GCNT2(3), ST8SIA1(1) 2694190 6 6 6 2 0 0 3 2 1 0 0.65 0.67 1.00 112 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(3), CD3E(1), CD3G(1), ITGAL(3), ITGB2(1) 3838757 9 8 9 2 1 1 2 4 1 0 0.55 0.69 1.00 113 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(2), TGDS(1), UXS1(1) 2183857 5 5 5 2 0 0 2 3 0 0 0.80 0.70 1.00 114 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOB(1), TPI1(2) 1713725 3 3 3 4 0 1 1 0 1 0 0.99 0.71 1.00 115 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 CTH(1), MUT(2) 2155409 3 3 3 0 1 0 1 0 1 0 0.46 0.71 1.00 116 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(7), CPT1A(1), LEPR(1), PRKAA1(1), PRKAG1(1), PRKAG2(1) 6358848 12 11 12 2 0 2 4 3 3 0 0.18 0.73 1.00 117 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CTH(1), GGT1(1), LCMT1(1), LCMT2(2), MARS(2), METTL6(1), PAPSS1(2), PAPSS2(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(1), SEPHS1(1), SEPHS2(1) 10994023 22 21 22 3 3 2 6 7 4 0 0.099 0.74 1.00 118 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(1), GBA3(2), GGT1(1), SHMT1(2), SHMT2(2) 2472863 8 8 8 5 0 0 3 2 3 0 0.92 0.74 1.00 119 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(1), HADH(1), HADHA(1), HADHB(1), HSD17B4(1), MECR(1) 3742101 6 6 6 1 1 3 2 0 0 0 0.22 0.74 1.00 120 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT2(2), B3GALT5(1), B3GNT5(1), ST3GAL3(1) 3159316 6 6 6 2 1 0 1 2 2 0 0.78 0.75 1.00 121 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1) 1323703 1 1 1 0 0 0 0 1 0 0 0.85 0.77 1.00 122 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGT(1), AGTR1(1), AGTR2(1), CMA1(1), COL4A1(2), COL4A3(2), COL4A4(3), COL4A5(7), COL4A6(5), REN(1) 11304644 26 24 26 5 5 0 11 6 4 0 0.095 0.77 1.00 123 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 CHAT(2), DBH(2), DDC(3), GAD1(1), MAOA(1), PAH(3), SLC18A3(2), TPH1(3) 6384604 17 16 17 4 2 1 6 7 1 0 0.31 0.78 1.00 124 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXTL1(1), EXTL2(1), EXTL3(2), GLCE(2), HS2ST1(1), HS3ST2(1), HS3ST3A1(1), HS3ST5(1), HS6ST3(1), NDST1(1), NDST2(2), NDST3(1), NDST4(3) 9149031 19 19 19 3 2 2 6 8 1 0 0.12 0.78 1.00 125 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ECHS1(1), EHHADH(2), HADHA(1), HADHB(1) 3657479 5 5 5 1 1 0 4 0 0 0 0.35 0.78 1.00 126 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP2(1), ACP5(1), ALPI(2), ALPL(1), ALPP(3), ALPPL2(1), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(1), PON3(1) 7927243 14 13 14 3 1 0 4 7 2 0 0.40 0.79 1.00 127 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(2), CALM2(1), DLG4(1), GRIN1(2), GRIN2A(3), GRIN2B(10), NOS1(7), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), SYT1(1) 11252255 36 35 36 8 6 1 11 18 0 0 0.18 0.79 1.00 128 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(2), IGF1(1), IL3(1), KITLG(2), TGFB2(1) 3640733 7 7 7 2 1 0 3 3 0 0 0.59 0.79 1.00 129 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), HLA-DRA(1), IFNA1(1), IL15(1), IL3(1), LTA(1), PDGFA(1), TGFB2(1) 5873734 8 8 8 1 0 0 2 5 1 0 0.47 0.80 1.00 130 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(2), CD3E(1), CD3G(1), IL2RA(2), TGFB2(1), TGFBR2(1), TGFBR3(1), TOB1(1), TOB2(1) 4666113 11 11 11 3 1 3 3 4 0 0 0.46 0.80 1.00 131 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC2(2), BIRC3(2), CASP10(2), CASP7(1), SCAP(1), SREBF1(1), SREBF2(2) 8044251 12 12 12 1 1 1 5 3 2 0 0.15 0.80 1.00 132 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GABBR1(1), GPRC5A(1), GPRC5B(1), GPRC5C(1), GPRC5D(1), GRM1(4), GRM2(2), GRM3(2), GRM4(2), GRM5(3), GRM7(1) 9179215 21 21 21 4 2 0 4 14 1 0 0.32 0.80 1.00 133 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 OXCT1(1) 1483753 1 1 1 1 0 0 0 0 1 0 0.95 0.81 1.00 134 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AMD1(1), BHMT(2), CTH(1), DNMT1(5), DNMT3A(4), DNMT3B(1), MARS(2), MTAP(2), MTR(1), TAT(1) 9166190 20 19 20 3 2 2 8 6 2 0 0.12 0.81 1.00 135 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPN1(1), CAPN2(1), EGF(3), EGFR(4), ITGA1(4), ITGB1(2), MAPK1(1), MAPK3(1), MYL2(1), MYLK(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), PTK2(1), PXN(2), TLN1(6) 14397042 36 33 36 6 4 3 13 12 4 0 0.080 0.81 1.00 136 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 IDI2(1), SQLE(1) 1891905 2 2 2 1 0 1 0 1 0 0 0.82 0.82 1.00 137 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CLOCK(3), CSNK1E(2), PER1(5), PER2(3), PER3(2) 7555584 16 16 16 4 4 2 4 3 3 0 0.27 0.83 1.00 138 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IL4R(2), IRS1(3), JAK1(4), JAK3(2), RPS6KB1(2), SHC1(2), STAT6(1) 6531736 17 17 17 4 4 0 4 6 3 0 0.38 0.83 1.00 139 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CLOCK(3), CSNK1E(2), PER1(5) 3771033 11 11 11 4 3 2 2 2 2 0 0.55 0.84 1.00 140 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(4), CD38(1), ENPP3(2), NMNAT2(1), NNMT(1), NNT(5), NT5M(1), QPRT(1) 6391550 16 15 16 4 1 1 4 7 3 0 0.32 0.84 1.00 141 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(1), AKT2(2), AKT3(2), CD19(1), CDKN2A(3), DAPP1(1), GAB1(1), ITPR1(2), ITPR2(7), ITPR3(1), LYN(1), PDK1(1), PIK3CA(14), PITX2(2), PLCG2(2), PPP1R13B(3), PREX1(6), PTEN(16), PTPRC(6), RPS6KA1(2), RPS6KA2(1), RPS6KB1(2), SAG(2), SYK(1), TEC(3), VAV1(2) 24524955 85 70 84 14 9 5 27 29 15 0 0.0034 0.85 1.00 142 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(1), MAP2K1(1), MAPK1(1), MAPK3(1), NGFR(1) 3634248 5 5 5 1 2 2 0 1 0 0 0.46 0.85 1.00 143 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(4), AMT(1), ATIC(1), DHFR(1), MTHFD1(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(2), SHMT2(2) 7871907 15 14 15 3 1 0 3 8 3 0 0.39 0.85 1.00 144 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(1), MAPK1(1), MAPK3(1), MAPK7(1), MEF2A(2), MEF2C(2), MEF2D(1), NTRK1(2), PIK3CA(14), PIK3R1(1), RPS6KA1(2), SHC1(2) 8365365 30 29 29 6 5 4 9 10 2 0 0.15 0.85 1.00 145 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), ARHGDIB(1), BIRC2(2), BIRC3(2), CASP1(1), CASP10(2), CASP2(2), CASP4(1), CASP7(1), LMNA(1) 8518937 14 14 14 2 1 1 5 6 1 0 0.24 0.85 1.00 146 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CD4(1), HLA-DRA(1) 2342493 2 2 2 1 0 0 0 1 1 0 0.97 0.86 1.00 147 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(1), MAX(3), SP1(1), SP3(1), TP53(13), WT1(3) 3105058 22 16 22 8 2 2 9 6 3 0 0.53 0.86 1.00 148 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 MAF(1), MAP2K3(2), MAPK14(1), NFATC1(1), NFATC2(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2) 5357406 13 12 13 4 5 0 1 6 1 0 0.51 0.86 1.00 149 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), MST1(1), MST1R(1) 2878073 3 3 3 0 0 0 0 2 1 0 0.67 0.86 1.00 150 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), DCXR(1), GUSB(2), RPE(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2A1(3), UGT2A3(4), UGT2B10(7), UGT2B11(2), UGT2B15(1), UGT2B7(2), XYLB(1) 12020690 38 34 36 9 5 3 11 15 4 0 0.19 0.86 1.00 151 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(1), DAXX(4), FAS(3) 4975857 8 8 8 2 1 0 2 5 0 0 0.53 0.86 1.00 152 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(2), CALM2(1), CAMK1(1), CAMK2D(1), CAMK2G(2), ESRRA(1), MEF2A(2), MEF2C(2), MEF2D(1), PPP3CB(1), PPP3CC(2), SYT1(1) 8970432 17 16 17 3 2 1 5 6 3 0 0.27 0.87 1.00 153 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), GPR171(2), GPR39(1), GPR45(2), GPR65(1), GPR75(1), GPR81(1) 4309754 9 9 9 3 1 0 3 4 1 0 0.51 0.87 1.00 154 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(3), EGFR(4), MAP2K1(1), MAP3K1(3), MAPK14(1), NCOR2(3), RARA(4), THRA(3) 7609040 22 20 22 5 1 2 8 4 7 0 0.29 0.87 1.00 155 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(7), ACACB(4), FASN(3), OXSM(2) 6983032 16 16 16 4 2 3 4 6 1 0 0.36 0.88 1.00 156 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), CYP11A1(1), CYP11B2(2), CYP17A1(2), CYP21A2(3), HSD3B1(1) 4128119 10 10 9 3 0 4 1 5 0 0 0.58 0.88 1.00 157 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), CYP11A1(1), CYP11B2(2), CYP17A1(2), CYP21A2(3), HSD3B1(1) 4128119 10 10 9 3 0 4 1 5 0 0 0.58 0.88 1.00 158 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(2), ALAS2(2), CPO(2), FECH(1), HBB(2) 3481691 9 9 9 4 1 0 2 4 2 0 0.83 0.88 1.00 159 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT6(1), ST3GAL3(1) 2240248 3 3 3 2 1 0 0 0 2 0 0.95 0.89 1.00 160 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(1), RDH5(1) 1706859 3 3 3 2 0 1 1 1 0 0 0.84 0.89 1.00 161 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15B(2), ALOX5(1), GGT1(1), LTA4H(3), PLA2G6(1), PTGDS(1), PTGES(1), PTGS2(4), TBXAS1(1) 6651337 15 14 15 4 1 2 3 5 4 0 0.53 0.89 1.00 162 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(4), AMT(1), ATIC(1), DHFR(1), MTHFD1(1), MTHFD2(1), MTHFR(1), MTR(1), SHMT1(2), SHMT2(2) 8345932 15 14 15 3 1 0 3 8 3 0 0.39 0.89 1.00 163 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), ACTR3(1), AKT1(1), AKT2(2), AKT3(2), ARHGEF11(2), CDC42(2), INPPL1(1), ITPR1(2), ITPR2(7), ITPR3(1), LIMK1(2), MYLK(3), MYLK2(2), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PDK1(1), PIK3CA(14), PIK3CD(1), PIK3CG(5), PIK3R1(1), PITX2(2), PPP1R13B(3), PTEN(16), RACGAP1(2), ROCK1(3), ROCK2(3), SAG(2), WASF1(2), WASL(5) 31022921 98 81 97 18 7 10 34 33 14 0 0.0035 0.90 1.00 164 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BID(1), BIRC2(2), BIRC3(2), CASP10(2), CASP7(1), CFLAR(1), GAS2(3), LMNA(1), MAP3K14(1), RELA(1), RIPK1(2), SPTAN1(3), TNFRSF10A(1), TRADD(1) 14767058 23 21 23 3 2 3 6 8 4 0 0.087 0.90 1.00 165 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CFLAR(1) 1691533 1 1 1 1 0 0 1 0 0 0 0.88 0.91 1.00 166 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 SQLE(1) 1418722 1 1 1 1 0 1 0 0 0 0 0.90 0.91 1.00 167 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD3E(1), CD3G(1), CD4(1), IL12RB2(1), JAK2(5), STAT4(2), TYK2(3) 6486123 14 14 14 4 0 2 3 8 1 0 0.58 0.91 1.00 168 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(5), C5(2), C6(4), C7(2) 5594293 13 13 13 4 2 2 3 4 2 0 0.54 0.91 1.00 169 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), IL3(1) 2686202 2 2 2 1 0 0 0 2 0 0 0.92 0.92 1.00 170 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(1), BID(1), BIRC2(2), BIRC3(2), CASP7(1) 5992369 7 7 7 1 0 1 3 3 0 0 0.33 0.93 1.00 171 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(5), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1) 5934839 14 13 14 4 1 1 5 5 2 0 0.50 0.93 1.00 172 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1) 5349255 10 10 10 3 1 0 6 3 0 0 0.48 0.93 1.00 173 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(3), PON3(1), RDH11(2) 3971309 6 6 6 2 1 1 1 3 0 0 0.69 0.93 1.00 174 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(1), GBA(1), GBA3(2), MPO(2), PRDX6(1), TPO(2) 3684648 9 9 9 3 1 1 5 2 0 0 0.50 0.93 1.00 175 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ITGAL(3), ITGAM(1), ITGB2(1), SELE(2) 4625912 9 9 9 3 2 0 4 2 1 0 0.56 0.93 1.00 176 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(2), AASDHPPT(1), AASS(5), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), BBOX1(1), DLST(2), DOT1L(3), ECHS1(1), EHHADH(2), EHMT1(1), EHMT2(2), GCDH(1), HADHA(1), PLOD2(3), PLOD3(2), SHMT1(2), SHMT2(2), TMLHE(1) 16336633 39 35 39 8 5 3 11 11 9 0 0.13 0.93 1.00 177 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K7(1), MAPK1(1), MAPK10(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), NFKBIL2(2), PIK3CA(14), PIK3CD(1), PIK3R1(1), SYT1(1), TRAF5(2), TRAF6(1) 14826086 36 35 35 8 4 4 9 15 4 0 0.16 0.94 1.00 178 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(1), IFNAR2(1), JAK1(4), STAT1(2), STAT2(3), TYK2(3) 4776663 15 15 15 6 2 1 5 4 3 0 0.72 0.94 1.00 179 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP2(1), ACP5(1), ENPP3(2), FLAD1(2), TYR(1) 4263689 7 7 7 4 0 0 2 2 3 0 0.92 0.95 1.00 180 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(4), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), AOC2(1), AOC3(1), CNDP1(3), DDC(3), MAOA(1), MAOB(1), PRPS1(1), PRPS2(2) 10778455 26 23 26 6 1 1 11 11 2 0 0.26 0.95 1.00 181 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCNE1(1), CDK2(1), CDK4(1), CDKN2A(3), E2F4(1), PRB1(4) 3990013 12 12 11 7 1 0 4 4 3 0 0.87 0.95 1.00 182 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(3), NAT1(1), NAT2(1), XDH(1) 3497119 8 8 8 3 2 0 2 4 0 0 0.65 0.95 1.00 183 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(1), PAPSS1(2), PAPSS2(1), SULT1A1(2), SULT1A2(2), SUOX(2) 4055018 10 10 9 6 3 2 2 1 2 0 0.90 0.95 1.00 184 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(2), COL4A3(2), COL4A4(3), COL4A5(7), COL4A6(5), SLC23A1(3), SLC23A2(2), SLC2A3(3) 11259433 27 25 27 7 4 0 12 8 3 0 0.20 0.95 1.00 185 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(1), CALM1(2), CALM2(1), CAMK2D(1), CAMK2G(2), F2(2), FYN(1), GNA11(1), GNAI1(2), GNB1(2), JAK2(5), MAP2K1(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(1), MAPT(2), MYLK(3), PTK2B(2), SHC1(2), SOS1(4), STAT1(2), STAT3(1), STAT5A(2), SYT1(1) 18364053 45 38 45 9 6 4 14 18 3 0 0.090 0.96 1.00 186 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(5), CS(2), DLD(4), DLST(2), FH(1), IDH1(2), IDH3B(2), MDH1(2), PC(1), PCK1(2), SDHA(1), SDHB(1), SUCLG1(2), SUCLG2(1) 9016608 28 27 28 9 2 1 8 12 5 0 0.60 0.96 1.00 187 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(1), ADH1C(1), ADHFE1(1) 2471016 4 4 4 3 1 1 1 0 1 0 0.92 0.96 1.00 188 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(2), HTR2C(1), PLCB1(1) 3145604 4 4 4 2 0 0 0 3 1 0 0.89 0.96 1.00 189 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(1), CYP11A1(1), CYP11B2(2), CYP17A1(2), HSD3B1(1) 3053914 7 7 7 3 0 1 2 4 0 0 0.71 0.96 1.00 190 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(2), ALAS2(2), FECH(1) 3346034 5 5 5 4 1 0 1 2 1 0 0.96 0.96 1.00 191 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), GRIA2(1), PPP1R1B(1) 1676642 3 3 3 2 1 0 0 2 0 0 0.90 0.96 1.00 192 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(2), B3GAT2(1), B3GAT3(1), CHST11(1), CHST7(1), DSE(1), XYLT1(1), XYLT2(2) 6153990 10 10 10 3 2 0 4 3 1 0 0.50 0.97 1.00 193 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(3), AP2A1(1), CALM1(2), CALM2(1), DNM1(1), EPN1(1), PICALM(2), PPP3CB(1), PPP3CC(2), SYNJ1(4), SYNJ2(3), SYT1(1) 9535432 22 21 22 5 1 1 8 10 2 0 0.29 0.97 1.00 194 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK4(2), EIF2B5(2), EIF2S1(1), EIF2S2(1), EIF5(2), GSK3B(1) 5099171 9 9 9 3 0 1 4 4 0 0 0.68 0.97 1.00 195 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IKBKB(1), IRAK1(3), MAP3K1(3), MAP3K14(1), MAP3K7(2), RELA(1), RIPK1(2), TLR4(1), TNFRSF1A(2), TRADD(1), TRAF6(1) 10754342 18 17 18 9 1 1 5 4 7 0 0.87 0.97 1.00 196 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), ADRBK2(1), CALM1(2), CALM2(1), CAMK2D(1), CAMK2G(2), CLCA2(3), CLCA4(3), CNGA4(1), CNGB1(2), PDC(1), PDE1C(2), PRKACA(1), PRKACB(1), PRKACG(2), PRKG1(2), PRKG2(3), PRKX(1) 13444322 30 28 30 6 7 1 10 9 3 0 0.10 0.97 1.00 197 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(4), EP300(6), IKBKB(1), MAP2K3(2), MAP3K14(1), MAP3K7(2), MAPK14(1), RELA(1), TGFBR2(1), TLR2(1) 13036750 20 19 20 4 1 1 8 9 1 0 0.23 0.97 1.00 198 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(10), MAP2(1), PPP2CA(1), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAR2B(2), PRKCE(4) 7992643 22 21 21 6 2 0 4 11 5 0 0.54 0.97 1.00 199 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(1), MMP2(1), RECK(2) 3304431 4 4 4 2 0 0 2 1 1 0 0.72 0.98 1.00 200 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(2), PAPSS2(1), SULT1A2(2), SUOX(2) 2676881 7 7 7 4 1 2 2 1 1 0 0.79 0.98 1.00 201 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(1), ARFGAP3(1), ARFGEF2(5), CLTA(1), COPA(3), GBF1(6), KDELR3(1) 7101885 19 18 19 5 1 1 5 10 1 1 0.47 0.98 1.00 202 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP2(1), ACP5(1), ENPP3(2), FLAD1(2), MTMR1(3), MTMR2(1), MTMR6(2), TYR(1) 6619215 13 13 13 6 0 0 3 5 5 0 0.84 0.98 1.00 203 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), CCNE1(1), CDK2(1), CUL1(3), RB1(2), SKP2(1) 3793988 9 9 9 7 0 1 4 2 2 0 0.94 0.98 1.00 204 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), JAK1(4), PTPRU(2), STAT1(2), STAT2(3), TYK2(3) 5509780 15 15 15 8 2 1 4 5 3 0 0.91 0.98 1.00 205 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CDK2(1), CUL1(3), RB1(2), SKP2(1) 3801372 8 8 8 5 0 1 3 2 2 0 0.88 0.98 1.00 206 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(2), RIPK1(2), TNFRSF1A(2), TRADD(1) 3721039 8 7 8 4 0 1 5 1 1 0 0.76 0.98 1.00 207 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNGR1(1), JAK1(4), JAK2(5), PTPRU(2), STAT1(2) 5073847 14 12 14 5 1 1 2 6 4 0 0.80 0.98 1.00 208 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADHFE1(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1) 5863437 11 10 11 5 1 1 3 3 3 0 0.80 0.98 1.00 209 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1) 3523590 6 6 6 3 0 0 3 3 0 0 0.82 0.98 1.00 210 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1) 3523590 6 6 6 3 0 0 3 3 0 0 0.82 0.98 1.00 211 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(1), AKT2(2), AKT3(2), IARS(2), IL4R(2), INPP5D(1), JAK1(4), JAK2(5), JAK3(2), PIK3CA(14), PPP1R13B(3), RPS6KB1(2), SHC1(2), SOS1(4), SOS2(1), SRC(1), STAT6(1), TYK2(3) 16276054 52 48 51 11 4 3 17 21 7 0 0.16 0.98 1.00 212 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(2), SP1(1), SP3(1) 2940945 4 4 4 7 0 0 3 0 1 0 1.00 0.98 1.00 213 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 DNAJC3(2), EIF2S1(1), EIF2S2(1), MAP3K14(1), RELA(1), TP53(13) 4340077 19 15 19 6 2 2 10 4 1 0 0.36 0.98 1.00 214 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), SDHA(1), SDHB(1), SDHD(1) 2899812 5 5 5 3 1 0 1 2 1 0 0.86 0.98 1.00 215 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(1), CHRNB1(1), MUSK(1), PIK3CA(14), PIK3R1(1), PTK2(1), PTK2B(2), SRC(1), TERT(3) 7197680 25 24 24 7 1 2 11 10 1 0 0.39 0.99 1.00 216 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 ESCO1(2), MYST3(6), MYST4(3), PNPLA3(1), SH3GLB1(1) 7282270 13 13 13 4 2 0 4 7 0 0 0.54 0.99 1.00 217 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(3), ADORA3(1), LTB4R(1), P2RY2(1), P2RY6(1) 2608883 7 7 7 4 0 1 2 3 1 0 0.88 0.99 1.00 218 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(1), GABRA1(1), GABRA3(1), GABRA4(3), GABRA5(2), GABRA6(1), GPHN(2), NSF(2), SRC(1), UBQLN1(2) 5254233 16 16 16 5 0 4 8 3 1 0 0.45 0.99 1.00 219 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 CS(2), FH(1), MDH1(2), OGDH(1), SDHA(1) 4117302 7 7 7 5 0 0 2 3 2 0 0.97 0.99 1.00 220 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGT(1), AGTR1(1), AGTR2(1), BDKRB2(1), KNG1(2), NOS3(1), REN(1) 4380275 10 9 10 4 2 0 4 4 0 0 0.63 0.99 1.00 221 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(4), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(1), DDC(3), EPX(1), ESCO1(2), GOT1(2), GOT2(3), HPD(1), MAOA(1), MAOB(1), MPO(2), MYST3(6), MYST4(3), PNPLA3(1), PRDX6(1), SH3GLB1(1), TAT(1), TPO(2) 15057565 40 36 40 9 4 2 16 15 3 0 0.14 0.99 1.00 222 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 BDH1(1), BDH2(1), HMGCS1(1), HMGCS2(1), OXCT1(1) 3170668 5 5 5 3 0 0 1 3 1 0 0.94 0.99 1.00 223 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT10(2), GALNT4(1), GALNT7(3), GALNT8(3), GALNT9(1), GCNT1(2), ST3GAL1(1), WBSCR17(4) 6330035 18 18 18 8 2 1 5 6 4 0 0.89 0.99 1.00 224 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3E(1), CD3G(1), CD4(1), CREBBP(4), CSK(2), GNAS(3), GNB1(2), HLA-DRA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), PTPRC(6), ZAP70(2) 10116848 30 26 30 7 3 2 7 16 2 0 0.36 0.99 1.00 225 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3E(1), CD3G(1), CD4(1), CREBBP(4), CSK(2), GNAS(3), GNB1(2), HLA-DRA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), PTPRC(6), ZAP70(2) 10116848 30 26 30 7 3 2 7 16 2 0 0.36 0.99 1.00 226 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 MAP2K1(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(1), NSMAF(2), RELA(1), RIPK1(2), SMPD1(1), TNFRSF1A(2), TRADD(1) 9044993 16 16 16 9 1 3 4 2 6 0 0.86 0.99 1.00 227 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CTH(1), GGT1(1), MARS(2), PAPSS1(2), PAPSS2(1), SEPHS1(1) 5453435 8 8 8 3 2 0 2 1 3 0 0.69 0.99 1.00 228 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(1), CDC42(2), ELK1(1), MAP2K1(1), MAPK3(1), PIK3CA(14), PIK3R1(1), RALBP1(1), RELA(1) 8420663 23 23 22 6 1 3 10 7 2 0 0.31 0.99 1.00 229 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), CS(2), MDH1(2), ME1(1), PC(1), PDHA1(1) 4060011 10 10 10 5 0 0 4 4 2 0 0.84 0.99 1.00 230 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(2), CD3E(1), CD3G(1), CD80(1), CD86(1), HLA-DRA(1), PIK3CA(14), PIK3R1(1), PTPN11(1) 5607184 23 23 22 7 1 4 7 9 2 0 0.49 0.99 1.00 231 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT1(1), B3GNT2(2), B3GNT3(1), B3GNT5(1), FUT6(1), GCNT2(3), ST8SIA1(1) 7079122 11 10 11 3 1 0 6 3 1 0 0.44 0.99 1.00 232 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 NOTCH1(4) 4096062 4 4 4 4 1 0 1 1 1 0 0.97 0.99 1.00 233 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 GREB1(6), MTA1(1), MTA3(1) 4849023 8 7 8 3 0 0 1 7 0 0 0.83 0.99 1.00 234 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 CHAT(2), PDHA1(1), SLC18A3(2) 3091388 5 5 5 3 1 0 0 4 0 0 0.90 0.99 1.00 235 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(4), APOBEC1(1), APOBEC3B(1), APOBEC4(2) 3220590 8 7 8 7 1 1 3 2 1 0 0.98 0.99 1.00 236 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), HMGCR(1), HMGCS1(1), LSS(1), PMVK(1), SC4MOL(2), SC5DL(1), SQLE(1) 5843787 9 9 9 3 0 1 0 7 1 0 0.79 0.99 1.00 237 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(1), EIF4A2(3), EIF4E(1), EIF4G1(5), EIF4G2(2), EIF4G3(3), GHR(1), IRS1(3), MAPK1(1), MAPK14(1), MAPK3(1), MKNK1(1), PABPC1(3), PDK2(1), PIK3CA(14), PIK3R1(1), PTEN(16), RPS6KB1(2) 12351835 60 51 59 15 2 7 17 24 10 0 0.15 0.99 1.00 238 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(2), CD86(1), HLA-DRA(1), IFNGR1(1), IL12RB2(1), IL2RA(2), IL4R(2) 5584435 10 10 10 4 2 1 1 4 2 0 0.78 0.99 1.00 239 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(2), B3GNT7(1), CHST1(1), CHST4(2), ST3GAL1(1), ST3GAL3(1) 5473470 9 9 9 3 0 0 6 1 2 0 0.58 0.99 1.00 240 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(3), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(2), SHMT1(2) 6625002 12 11 12 4 1 1 3 6 1 0 0.69 0.99 1.00 241 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(3), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(2), SHMT1(2) 6625002 12 11 12 4 1 1 3 6 1 0 0.69 0.99 1.00 242 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(3), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(2), SHMT1(2) 6625002 12 11 12 4 1 1 3 6 1 0 0.69 0.99 1.00 243 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(4), JAK2(5), JAK3(2), MAPK1(1), MAPK3(1), STAT3(1), TYK2(3) 5194946 17 16 17 6 2 2 3 7 3 0 0.76 0.99 1.00 244 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALT5(1), GBGT1(2), HEXA(3), ST3GAL1(1), ST8SIA1(1) 4715338 8 8 8 3 2 0 1 5 0 0 0.76 0.99 1.00 245 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNA1(1), IKBKB(1), IL1RAP(2), IRAK1(3), IRAK3(1), JUN(1), MAP2K3(2), MAP3K1(3), MAP3K14(1), MAP3K7(2), MAPK14(1), MAPK8(1), RELA(1), TGFB2(1), TRAF6(1) 13044849 22 20 22 5 4 0 7 5 6 0 0.28 0.99 1.00 246 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(1), GOT1(2), GOT2(3), GPT2(1), MDH1(2), ME1(1), ME2(2), ME3(1), PGK1(2), RPE(1), TPI1(2) 7882558 18 17 18 8 1 1 9 3 4 0 0.73 0.99 1.00 247 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(3), ACO1(5), ACSS1(2), ACSS2(3), FH(1), IDH1(2), MDH1(2) 5827481 18 17 18 7 1 1 6 7 3 0 0.74 1.00 1.00 248 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(2), CALM2(1), MAP3K1(3), NFATC1(1), NFATC2(2), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), RELA(1), SYT1(1), VIPR2(1) 12271098 21 21 21 5 5 0 5 7 4 0 0.30 1.00 1.00 249 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT5(1), ST3GAL1(1), ST3GAL3(1) 3454798 4 4 4 3 0 0 2 1 1 0 0.92 1.00 1.00 250 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 IKBKAP(3), IKBKB(1), LTA(1), MAP3K1(3), MAP3K14(1), RELA(1), RIPK1(2), TANK(1) 9866591 13 13 13 4 1 0 4 3 5 0 0.51 1.00 1.00 251 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 PLCB1(1), RELA(1) 3615455 2 2 2 3 0 0 1 0 1 0 0.97 1.00 1.00 252 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(2), AGT(1), AGTR1(1), AGTR2(1), ANPEP(3), CMA1(1), CTSA(2), ENPEP(3), LNPEP(2), MAS1(1), MME(1), REN(1) 9322963 21 20 21 6 2 2 9 6 2 0 0.42 1.00 1.00 253 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ITPKA(1), ITPKB(2) 2694444 3 3 3 2 2 0 1 0 0 0 0.80 1.00 1.00 254 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 IKBKAP(3), IKBKB(1), MAP3K1(3), MAP3K14(1), RELA(1), TRAF6(1) 7972844 10 10 10 4 0 0 3 2 5 0 0.75 1.00 1.00 255 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(3), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(2), SHMT1(2) 7051363 12 11 12 4 1 1 3 6 1 0 0.68 1.00 1.00 256 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNAR1(1), IFNAR2(1), MAPK8(1), RELA(1), TNFSF11(1), TRAF6(1) 4882888 6 6 6 3 0 0 3 2 1 0 0.86 1.00 1.00 257 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR2(1), ITPKA(1), PDE1B(2), PLCB1(1), PLCB2(1) 4889322 6 6 6 4 1 0 2 1 2 0 0.91 1.00 1.00 258 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(2), F5(5), FGA(2), FGB(1), FGG(2), PROC(2), PROS1(5), TFPI(1) 7200982 20 19 20 7 2 0 6 8 4 0 0.70 1.00 1.00 259 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), DCXR(1), GUSB(2), RPE(1), UCHL3(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2B15(1) 7739282 20 17 20 6 2 3 8 4 3 0 0.43 1.00 1.00 260 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(2), PSMB5(1), PSMB7(1) 3834059 9 8 9 5 0 0 3 5 1 0 0.94 1.00 1.00 261 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(2), CALM2(1), CDKN1A(1), MARCKS(3), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), PPP3CB(1), PPP3CC(2), SP1(1), SP3(1), SYT1(1) 9201815 21 21 20 9 3 0 6 7 5 0 0.86 1.00 1.00 262 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 GBGT1(2), HEXA(3), ST3GAL1(1), ST8SIA1(1) 4443749 7 7 7 3 1 0 1 5 0 0 0.84 1.00 1.00 263 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(5), C5(2), C6(4), C7(2), ITGA4(2), ITGAL(3), ITGB1(2), ITGB2(1), SELP(2), SELPLG(1), VCAM1(2) 10973335 26 26 26 8 3 3 8 8 4 0 0.43 1.00 1.00 264 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(1), GOT1(2), GOT2(3), GPT2(1), MDH1(2), ME1(1), ME3(1), PGK1(2), RPE(1), TKTL1(1), TKTL2(2), TPI1(2) 8811660 19 19 19 9 1 1 9 4 4 0 0.79 1.00 1.00 265 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(4), JAK2(5), JAK3(2), PIAS1(2), PIAS3(1), PTPRU(2) 6132797 16 13 16 5 1 2 3 7 3 0 0.69 1.00 1.00 266 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(1), PIK3CA(14), PIK3R1(1), PLCB1(1), VAV1(2) 5606642 19 19 18 9 1 3 7 6 2 0 0.81 1.00 1.00 267 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(1), ADSL(1), AGXT(1), CAD(2), CRAT(1), DARS(2), GAD1(1), GOT1(2), GOT2(3), GPT2(1), PC(1) 11461849 17 16 17 7 3 1 5 2 6 0 0.73 1.00 1.00 268 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), ARHGEF1(1), GNA13(2), GNB1(2), MYL2(1), MYLK(3), PLCB1(1), PPP1R12B(1), ROCK1(3) 9099116 17 17 17 8 0 0 2 11 4 0 0.92 1.00 1.00 269 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(2), LARS(1), PDHA1(1), PDHB(1) 4404428 5 5 5 3 0 0 1 3 1 0 0.91 1.00 1.00 270 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), HMGB2(1), TOP2A(1), TOP2B(1) 4233288 4 4 4 2 0 0 2 2 0 0 0.82 1.00 1.00 271 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD33(1), CD7(1), IFNA1(1), IL3(1), ITGAX(2), TLR2(1), TLR4(1), TLR7(1) 8173001 12 12 12 4 2 0 4 5 1 0 0.57 1.00 1.00 272 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(1), GSS(1), NOX1(2), RELA(1), XDH(1) 4390038 6 6 6 3 0 0 2 4 0 0 0.81 1.00 1.00 273 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR4(1), CD28(2), CD4(1), CXCR4(1), IFNGR1(1), IL12RB2(1), IL4R(2), TGFB2(1) 8798869 10 10 10 3 2 2 2 3 1 0 0.48 1.00 1.00 274 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 HMOX1(2), JAK1(4), STAT1(2), STAT3(1), STAT5A(2) 5371872 11 11 11 5 1 1 3 4 2 0 0.85 1.00 1.00 275 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(2), PSMB5(1), PSMB7(1), RPN1(1), RPN2(2), UBE3A(1) 5700557 13 12 13 6 0 0 3 8 2 0 0.92 1.00 1.00 276 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(1), GNAS(3), GNB1(2), PPP2CA(1), PRKAA1(1), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAG2(1), PRKAR1A(1), PRKAR2B(2) 6725306 16 16 16 5 2 0 3 10 1 0 0.68 1.00 1.00 277 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR7(1), HMGCR(1), HSD17B7(2), IDI2(1), LSS(1), PMVK(1), SC4MOL(2), SC5DL(1), SQLE(1), TM7SF2(1) 8543218 12 12 11 4 0 1 2 7 2 0 0.77 1.00 1.00 278 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), CYP2C19(1), CYP2C9(1), ECHS1(1), EHHADH(2), ESCO1(2), HADHA(1), MYST3(6), MYST4(3), PNPLA3(1), SH3GLB1(1) 13592705 25 23 25 7 3 0 10 10 2 0 0.32 1.00 1.00 279 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 JAK1(4), JAK2(5), JAK3(2), PIAS3(1), PTPRU(2), SRC(1), STAT3(1) 6761607 16 14 16 7 1 1 3 8 3 0 0.91 1.00 1.00 280 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CASP2(2), IKBKB(1), JUN(1), LTA(1), MAP2K3(2), MAP3K1(3), MAP3K14(1), MAPK14(1), MAPK8(1), RELA(1), RIPK1(2), TANK(1), TNFRSF1A(2), TRADD(1) 10664710 21 19 21 7 2 1 5 8 5 0 0.64 1.00 1.00 281 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), ABP1(4), AOC2(1), AOC3(1), CES1(2), CES7(1), DDHD1(1), ESCO1(2), MYST3(6), MYST4(3), PNPLA3(1), PRDX6(1), SH3GLB1(1) 11168902 25 23 25 7 2 1 8 13 1 0 0.41 1.00 1.00 282 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BCL10(1), BID(1), CASP8AP2(4), CES1(2) 4995536 9 8 9 5 0 2 2 4 1 0 0.90 1.00 1.00 283 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(1), AKT2(2), AKT3(2), GSK3A(1), GSK3B(1), IL4R(2), IRS1(3), IRS2(1), JAK1(4), JAK3(2), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(14), PIK3CD(1), PIK3R1(1), PPP1R13B(3), SHC1(2), SOS1(4), SOS2(1), STAT6(1) 16097245 49 44 48 11 7 4 15 19 4 0 0.15 1.00 1.00 284 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), HMGCR(1), LSS(1), PMVK(1), SC5DL(1), SQLE(1) 4913479 6 6 6 3 0 1 0 5 0 0 0.88 1.00 1.00 285 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(2), DPYD(1), DPYS(1), ENPP3(2), PANK1(1), PANK2(2), PANK3(1), UPB1(1) 6140217 11 10 11 9 1 0 3 5 2 0 0.98 1.00 1.00 286 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), IL3(1), IL3RA(1), JAK2(5), MAP2K1(1), MAPK3(1), PTPN6(1), SHC1(2), SOS1(4), STAT5A(2) 7781068 19 19 19 6 2 3 5 8 1 0 0.53 1.00 1.00 287 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), GLB1(4), HEXA(3), LCT(1), SLC33A1(3), ST3GAL1(1), ST3GAL5(1), ST6GALNAC5(2), ST8SIA1(1), ST8SIA5(1) 7220801 18 17 18 6 3 0 4 9 2 0 0.68 1.00 1.00 288 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(3), ABCC2(2), ABCG2(1), BCHE(1), CES1(2), CES2(1), CYP3A4(1), CYP3A5(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1) 10005015 24 21 24 8 2 5 7 7 3 0 0.52 1.00 1.00 289 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(1), EPHB1(1), FYN(1), ITGA1(4), ITGB1(2), L1CAM(3), LYN(1), RAP1B(2), SELP(2) 6922781 17 15 17 6 1 3 6 6 1 0 0.63 1.00 1.00 290 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAP3K14(1), MAPK14(1), MAPK8(1), RELA(1), TRAF5(2), TRAF6(1) 6410368 7 7 7 3 0 0 3 3 1 0 0.79 1.00 1.00 291 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ITGA4(2), ITGAL(3), ITGB1(2), ITGB2(1), SELE(2) 5373022 12 12 12 5 1 0 8 2 1 0 0.64 1.00 1.00 292 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(1), ADRB2(1), GNAS(3), PLCE1(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), RAP2B(1) 6458913 15 15 15 5 2 0 5 7 1 0 0.67 1.00 1.00 293 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPS7(1), RPL10L(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL27(1), RPL28(2), RPL3(1), RPL30(2), RPL31(1), RPL34(1), RPL3L(1), RPL7(1), RPL9(1), RPS11(1), RPS13(1), RPS2(1), RPS21(1), RPS24(1), RPS26(2), RPS27(1), RPS29(1), RPS3(1), RPS3A(1), RPS4Y1(1) 10108851 31 30 31 8 4 2 8 14 3 0 0.35 1.00 1.00 294 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), SCAP(1), SREBF1(1), SREBF2(2) 5259103 5 5 5 3 1 0 2 1 1 0 0.88 1.00 1.00 295 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 ELK1(1), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(1), NGFR(1), PIK3CA(14), PIK3R1(1), SHC1(2), SOS1(4) 8403511 27 26 26 9 2 3 10 11 1 0 0.54 1.00 1.00 296 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(2), BIRC3(2), CFLAR(1), JUN(1), MAP3K7(2), NFKBIL2(2), RALBP1(1), RIPK1(2), TNFRSF1A(2), TRADD(1) 11993169 17 15 17 9 0 2 7 5 3 0 0.90 1.00 1.00 297 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(5), CS(2), GRHPR(1), MDH1(2), MTHFD1(1), MTHFD2(1) 5608237 12 12 12 6 1 1 2 7 1 0 0.82 1.00 1.00 298 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP2(1), ACP5(1), ALPI(2), ALPL(1), ALPP(3), ALPPL2(1), CYP19A1(3), CYP1A1(1), CYP1A2(2), CYP2A13(3), CYP2B6(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(2), CYP2F1(1), CYP2J2(1), CYP3A4(1), CYP3A5(1), CYP3A7(1), CYP4B1(1) 12896158 30 28 30 9 5 1 9 13 2 0 0.38 1.00 1.00 299 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT1(1), AKT2(2), AKT3(2), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(1), NFKBIL2(2), PDK1(1), PHKA2(1), PIK3CB(2), PITX2(2), PLD1(3), PLD3(1) 19777186 31 28 31 6 6 2 9 11 3 0 0.094 1.00 1.00 300 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(9), AKT1(1), ATM(15), CDKN1A(1), CSNK1A1(1), FHL2(1), HIC1(1), HIF1A(3), MAPK8(1), TP53(13) 9166900 46 38 46 13 2 2 18 11 13 0 0.33 1.00 1.00 301 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(5), CS(2), GRHPR(1), MDH1(2), MTHFD1(1), MTHFD2(1) 5876819 12 12 12 6 1 1 2 7 1 0 0.82 1.00 1.00 302 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 IARS(2), IARS2(2), ILVBL(1), LARS(1), PDHA1(1), PDHB(1), VARS(2), VARS2(3) 8156296 13 12 13 6 0 0 4 6 3 0 0.82 1.00 1.00 303 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(4), ADH1A(1), ADH1B(1), ADH1C(1), ADHFE1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(1), AOX1(4), DBH(2), DCT(2), DDC(3), GOT1(2), GOT2(3), HGD(2), HPD(1), MAOA(1), MAOB(1), TAT(1), TPO(2), TYR(1) 13983878 38 33 38 10 3 3 14 12 6 0 0.31 1.00 1.00 304 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(1), NTRK1(2), PIK3CA(14), PIK3R1(1), SHC1(2), SOS1(4) 6836607 24 23 23 8 1 2 10 10 1 0 0.55 1.00 1.00 305 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(7), ACACB(4), ACOT12(1), ACSS1(2), ACSS2(3), AKR1B1(2), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), DLAT(2), DLD(4), GRHPR(1), HAGH(1), HAGHL(1), LDHAL6B(1), LDHB(1), LDHC(2), MDH1(2), ME1(1), ME2(2), ME3(1), PC(1), PCK1(2), PCK2(2), PDHA1(1), PDHB(1) 20565587 51 44 51 12 3 3 20 14 11 0 0.15 1.00 1.00 306 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ABAT(1), ACADS(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), ECHS1(1), EHHADH(2), GAD1(1), HADHA(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHB(1), SDHB(1) 11322600 19 19 18 6 5 0 7 5 2 0 0.42 1.00 1.00 307 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CD44(2), FCGR3A(1), TGFB2(1), TNFRSF1A(2) 5889850 8 8 8 6 1 0 5 1 1 0 0.92 1.00 1.00 308 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(4), ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADHFE1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(1), AOX1(4), DBH(2), DCT(2), DDC(3), ESCO1(2), GOT1(2), GOT2(3), HGD(2), HPD(1), LCMT1(1), LCMT2(2), MAOA(1), MAOB(1), METTL6(1), MYST3(6), MYST4(3), PNPLA3(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(1), SH3GLB1(1), TAT(1), TPO(2), TYR(1), TYRP1(1) 26226299 66 58 66 15 6 4 23 26 7 0 0.11 1.00 1.00 309 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), IKBKB(1), JUN(1), MAP3K1(3), MAP3K5(4), MAPK14(1), MAPK8(1), RELA(1), TNFRSF9(1) 8579355 14 13 14 6 0 1 3 7 3 0 0.80 1.00 1.00 310 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(1), POLR1B(2), POLR2A(5), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(2), POLR3B(4), POLR3G(2), POLR3H(1) 10330955 23 22 21 7 2 3 10 6 2 0 0.41 1.00 1.00 311 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(1), AKT2(2), AKT3(2), BRD4(4), CBL(2), CDC42(2), CDKN2A(3), F2RL2(1), GSK3A(1), GSK3B(1), INPPL1(1), IRS1(3), IRS2(1), LNPEP(2), MAPK1(1), MAPK3(1), PARD3(3), PDK1(1), PIK3CA(14), PIK3CD(1), PIK3R1(1), PTEN(16), PTPN1(1), RPS6KA1(2), RPS6KA2(1), RPS6KB1(2), SERPINB6(1), SHC1(2), SORBS1(1), SOS1(4), SOS2(1), YWHAE(2) 26163779 81 68 80 18 6 7 26 30 12 0 0.045 1.00 1.00 312 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA3(1), ANXA4(1), ANXA6(1), CYP11A1(1), EDNRB(1), HPGD(1), PTGDS(1), PTGER2(1), PTGFR(1), PTGIR(1), PTGS2(4), TBXAS1(1) 9111411 15 15 15 8 1 1 4 6 3 0 0.88 1.00 1.00 313 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(1), ALDH18A1(1), ARG1(1), CPS1(5), GLUD1(2), OTC(1), PYCR1(1), SMS(2) 7691829 14 14 14 6 1 0 7 4 2 0 0.79 1.00 1.00 314 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(4), ACTR2(2), ACTR3(1), AKT1(1), CDC42(2), FLNA(3), FLNC(6), FSCN1(3), LIMK1(2), MYH2(6), MYLK(3), MYLK2(2), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), ROCK1(3), ROCK2(3), WASF1(2), WASL(5) 21101553 56 48 56 13 5 6 18 21 6 0 0.099 1.00 1.00 315 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(3), AGT(1), AGTR2(1), EDNRB(1), EGF(3), EGFR(4), JUN(1), RELA(1) 9012433 15 15 15 7 1 0 6 5 3 0 0.86 1.00 1.00 316 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(4), CD38(1), ENPP3(2), NMNAT2(1), NMNAT3(1), NNMT(1), NNT(5), NT5C1B(1), NT5C3(1), NT5M(1), QPRT(1) 9482643 19 18 19 7 1 1 5 9 3 0 0.62 1.00 1.00 317 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADHFE1(1), AKR1B10(3), AKR1C4(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(1), HADHB(1), RDH11(2), SLC27A5(2), SOAT2(1), SRD5A1(1) 13995305 26 24 26 9 3 3 8 8 4 0 0.52 1.00 1.00 318 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ECHS1(1), EHHADH(2), ESCO1(2), GCDH(1), HADHA(1), MYST3(6), MYST4(3), PNPLA3(1), SH3GLB1(1) 11407061 18 18 18 5 4 0 7 7 0 0 0.34 1.00 1.00 319 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), CYB5R3(2), GNE(1), HEXA(3), RENBP(2), UAP1(1) 7440957 10 9 10 6 1 1 2 4 2 0 0.91 1.00 1.00 320 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1R(1), C1S(2), C3(5), C5(2), C6(4), C7(2) 7805566 16 16 16 6 3 2 4 5 2 0 0.70 1.00 1.00 321 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(1), ARF1(1), EEA1(5), GSK3A(1), GSK3B(1), LYN(1), PFKL(2), PFKM(1), PRKCE(4), RPS6KB1(2), VAV2(3) 11032220 23 20 22 7 1 2 6 9 5 0 0.57 1.00 1.00 322 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 ELK1(1), IKBKB(1), IRAK1(3), JUN(1), MAP2K3(2), MAP3K1(3), MAP3K14(1), MAP3K7(2), MAPK14(1), MAPK8(1), RELA(1), TLR10(1), TLR2(1), TLR4(1), TLR6(1), TLR7(1), TRAF6(1) 16060809 23 20 23 8 2 0 7 8 6 0 0.59 1.00 1.00 323 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), EP300(6), MAPK1(1), MAPK3(1), SRC(1) 6461222 13 13 13 5 1 2 6 4 0 0 0.62 1.00 1.00 324 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(4), EP300(6), IKBKB(1), RELA(1), RIPK1(2), TNFRSF1A(2), TRADD(1), TRAF6(1) 9863487 18 18 18 7 0 2 9 5 2 0 0.64 1.00 1.00 325 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1R(1), C1S(2), C3(5), C5(2), C6(4), C7(2), C8B(1), MASP1(1) 9249616 18 18 18 6 5 2 4 5 2 0 0.58 1.00 1.00 326 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2D(1), CAMK2G(2), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(1), NFAT5(3), PDE6A(2), PDE6B(1), PDE6C(2), SLC6A13(1), TF(1) 15816674 26 25 26 7 7 2 5 10 2 0 0.33 1.00 1.00 327 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(3), ARSE(1), GAL3ST1(2), GALC(1), GBA(1), GLB1(4), LCT(1), NEU1(1), NEU3(1), PPAP2B(1), SMPD1(1) 10730725 17 16 17 8 0 0 5 8 4 0 0.89 1.00 1.00 328 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(3), JUN(1), MAP2K1(1), MAPK1(1), MAPK3(1), PLCB1(1), RELA(1) 6794927 9 9 9 5 3 3 1 1 1 0 0.79 1.00 1.00 329 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1R(1), C1S(2), C3(5), C5(2), C6(4), C7(2), MASP1(1), MBL2(1) 9487038 18 18 18 6 4 2 5 5 2 0 0.57 1.00 1.00 330 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(2), PSMB5(1), PSMB7(1), PSMC2(1), PSMD11(1), PSMD2(1), PSMD6(1) 7007641 13 12 13 7 1 0 5 6 1 0 0.92 1.00 1.00 331 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ITGA4(2), ITGAL(3), ITGAM(1), ITGB1(2), ITGB2(1), SELE(2), SELP(2) 7069153 15 15 15 6 2 1 8 3 1 0 0.59 1.00 1.00 332 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(2), AKT1(1), AKT2(2), AKT3(2), APAF1(1), ATM(15), BID(1), BIRC2(2), BIRC3(2), CAPN1(1), CAPN2(1), CASP10(2), CASP7(1), CFLAR(1), CSF2RB(1), FAS(3), IKBKB(1), IL1RAP(2), IL3(1), IL3RA(1), IRAK1(3), IRAK3(1), IRAK4(1), MAP3K14(1), NTRK1(2), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKACA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), RELA(1), RIPK1(2), TNFRSF10A(1), TNFRSF1A(2), TP53(13), TRADD(1) 36977199 108 81 107 23 9 7 40 37 15 0 0.014 1.00 1.00 333 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(2), CHIT1(2), CMAS(1), CTBS(1), CYB5R1(2), CYB5R3(2), GFPT2(2), GNE(1), HEXA(3), MTMR1(3), MTMR2(1), MTMR6(2), NAGK(2), NANS(1), RENBP(2), UAP1(1) 12629144 29 27 29 9 3 2 8 11 5 0 0.44 1.00 1.00 334 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(1), CDC25C(2), GNAI1(2), GNAS(3), GNB1(2), MAPK1(1), MAPK3(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), RPS6KA1(2), SRC(1) 8990358 21 19 21 9 4 1 4 11 1 0 0.83 1.00 1.00 335 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(2), DDX20(4), E2F4(1), ETS1(1), JUN(1), NCOR2(3), RBL2(3), SIN3A(2), SIN3B(2) 11484628 19 18 19 8 0 1 6 8 4 0 0.76 1.00 1.00 336 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADM(1), ACADS(2), ACSL1(2), ACSL3(1), ACSL4(1), CPT1A(1), EHHADH(2), HADHA(1), PECR(2), SCP2(2), SLC25A20(1) 7374640 16 15 15 8 2 2 9 2 1 0 0.63 1.00 1.00 337 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), GLB1(4), HEXA(3), LCT(1), MAN2C1(5), NEU1(1), NEU3(1) 7309134 16 15 16 6 2 1 4 9 0 0 0.77 1.00 1.00 338 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(4), CALM1(2), CALM2(1), CAPN2(1), EP300(6), HDAC1(1), MEF2D(1), NFATC1(1), NFATC2(2), PPP3CB(1), PPP3CC(2), SYT1(1) 10704336 23 22 23 9 4 1 7 10 1 0 0.65 1.00 1.00 339 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 AGT(1), AKT1(1), CALM1(2), CALM2(1), CALR(1), CAMK1(1), CREBBP(4), CSNK1A1(1), ELSPBP1(1), F2(2), GATA4(1), GSK3B(1), IGF1(1), MAP2K1(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(1), MEF2C(2), MYH2(6), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), NPPA(1), PIK3CA(14), PIK3R1(1), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), RPS6KB1(2), SYT1(1) 22314531 67 59 66 17 9 6 22 23 7 0 0.11 1.00 1.00 340 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(2), EGF(3), EGFR(4), MAP2K1(1), MAPK1(1), MAPK3(1), PTPRB(3), RASA1(2), SHC1(2), SOS1(4), SPRY2(2), SPRY4(1), SRC(1) 11003331 27 25 27 9 3 2 13 6 3 0 0.53 1.00 1.00 341 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(1), AKT2(2), AKT3(2), CDC42(2), CDK2(1), CDKN2A(3), ERBB4(7), F2RL2(1), GAB1(1), GSK3A(1), GSK3B(1), IGF1(1), INPPL1(1), IRS1(3), IRS2(1), MET(5), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PARD3(3), PDK1(1), PIK3CA(14), PIK3CD(1), PPP1R13B(3), PREX1(6), PTEN(16), PTK2(1), PTPN1(1), RPS6KA1(2), RPS6KA2(1), RPS6KB1(2), SHC1(2), SOS1(4), SOS2(1), TSC1(4), TSC2(2), YWHAE(2) 34089171 107 84 106 25 7 9 35 42 14 0 0.055 1.00 1.00 342 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 ELK1(1), IL6ST(3), JAK1(4), JAK2(5), JAK3(2), JUN(1), MAP2K1(1), MAPK3(1), PTPN11(1), SHC1(2), SOS1(4), STAT3(1) 10540593 26 25 26 9 3 2 7 11 3 0 0.72 1.00 1.00 343 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX5(1), CBR1(2), CYP4F2(1), EPX(1), GGT1(1), LTA4H(3), MPO(2), PLA2G6(1), PRDX1(1), PRDX5(1), PRDX6(1), PTGDS(1), PTGS2(4), TBXAS1(1), TPO(2) 12256936 23 23 23 9 4 4 5 6 4 0 0.71 1.00 1.00 344 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), GLB1(4), HEXA(3), LCT(1), MAN2B2(1), MAN2C1(5), NEU1(1), NEU3(1) 9003302 17 15 17 6 2 1 4 10 0 0 0.73 1.00 1.00 345 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), EP300(6), LPL(1), NCOA1(2), NCOA2(2), PPARG(1) 8128528 16 15 16 8 1 2 7 5 1 0 0.79 1.00 1.00 346 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(1), AKT2(2), AKT3(2), BRAF(5), FIGF(2), HIF1A(3), IGF1(1), MAPK1(1), MAPK3(1), PGF(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PRKAA1(1), RHEB(2), RICTOR(4), RPS6KA1(2), RPS6KA2(1), RPS6KA6(3), RPS6KB1(2), RPS6KB2(1), TSC1(4), TSC2(2), ULK1(1), ULK2(2), ULK3(2) 23609369 72 61 71 18 6 5 24 22 15 0 0.13 1.00 1.00 347 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3E(1), CD3G(1), IL12RB2(1), JAK2(5), JUN(1), MAPK14(1), MAPK8(1), STAT4(2), TYK2(3) 8213744 16 15 16 6 0 2 4 9 1 0 0.76 1.00 1.00 348 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ADH1A(1), ADH1B(1), ADH1C(1), ADHFE1(1), AKR1C4(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(1), HADHB(1), SOAT2(1), SRD5A1(1) 10231826 18 18 18 9 1 2 8 5 2 0 0.84 1.00 1.00 349 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 AKT1(1), BDKRB2(1), CALM1(2), CALM2(1), CHRNA1(2), FLT1(3), FLT4(4), KDR(5), NOS3(1), PDE2A(3), PDE3A(3), PDE3B(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), PRKG1(2), PRKG2(3), RYR2(12), SLC7A1(1), SYT1(1), TNNI1(1) 18134657 55 49 55 15 13 3 14 20 5 0 0.20 1.00 1.00 350 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(7), ADH5(1), AKR1B1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), DLAT(2), DLD(4), GRHPR(1), HAGH(1), HAGHL(1), LDHB(1), LDHC(2), MDH1(2), ME1(1), ME2(2), ME3(1), PC(1), PCK1(2), PDHA1(1), PDHB(1) 16271045 39 34 39 11 0 2 17 13 7 0 0.38 1.00 1.00 351 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), B4GALT5(1), DDOST(1), DPAGT1(2), MGAT3(1), MGAT4A(3), MGAT5(3), RPN1(1), RPN2(2) 8732764 15 14 15 7 3 1 4 6 1 0 0.81 1.00 1.00 352 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), ARSB(3), GALNS(1), GBA(1), GLB1(4), GNS(1), GUSB(2), HEXA(3), HGSNAT(3), HPSE(1), HPSE2(1), HYAL2(1), IDS(3), IDUA(1), LCT(1), MAN2B2(1), MAN2C1(5), NEU1(1), NEU3(1), SPAM1(5) 15243040 40 32 40 11 7 2 11 18 2 0 0.34 1.00 1.00 353 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 CD97(1), CRHR2(1), ELTD1(2), GHRHR(1), GIPR(1), GLP1R(1), GPR64(2), LPHN1(2), LPHN2(2), LPHN3(4), SCTR(1), VIPR1(1), VIPR2(1) 11846665 20 19 20 7 1 2 5 10 2 0 0.59 1.00 1.00 354 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 ELK1(1), JAK2(5), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(1), PTPN6(1), SHC1(2), SOS1(4), STAT5A(2) 9470400 19 18 19 9 2 3 6 7 1 0 0.84 1.00 1.00 355 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(4), AGXT(1), AKR1B10(3), ALAS1(2), ALAS2(2), AMT(1), AOC2(1), AOC3(1), BHMT(2), CHKB(1), CTH(1), DAO(1), DLD(4), DMGDH(2), GARS(1), GNMT(1), MAOA(1), MAOB(1), PHGDH(1), PISD(1), PSAT1(2), RDH11(2), SARDH(2), SARS(1), SHMT1(2), SHMT2(2), TARS(1), TARS2(2) 18923535 46 43 46 12 5 4 17 16 4 0 0.19 1.00 1.00 356 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADHFE1(1), ESCO1(2), MYST3(6), MYST4(3), PNPLA3(1), SH3GLB1(1) 11000260 18 18 18 7 3 1 5 8 1 0 0.71 1.00 1.00 357 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), CAD(2), CPS1(5), EPRS(1), GAD1(1), GLS(1), GLS2(1), GLUD1(2), GOT1(2), GOT2(3), GPT2(1), GSS(1), QARS(1) 14608519 22 21 22 9 3 0 10 6 3 0 0.69 1.00 1.00 358 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(1), AKT2(2), AKT3(2), CD80(1), CD86(1), CXCL11(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR1(1), IFNAR2(1), IKBKB(1), IKBKE(1), IRAK1(3), IRAK4(1), JUN(1), MAP2K1(1), MAP2K3(2), MAP2K7(1), MAP3K7(2), MAPK1(1), MAPK10(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(1), MAPK9(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), RELA(1), RIPK1(2), SPP1(1), STAT1(2), TICAM1(3), TLR1(2), TLR2(1), TLR4(1), TLR5(1), TLR6(1), TLR7(1), TLR8(3), TRAF6(1) 39556002 85 74 84 18 6 6 24 38 11 0 0.048 1.00 1.00 359 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CHN1(2), LIMK1(2), MAP3K1(3), MYL2(1), MYLK(3), NCF2(1), PAK1(1), PDGFRA(6), PIK3CA(14), PIK3R1(1), PLD1(3), PPP1R12B(1), RALBP1(1), RPS6KB1(2), TRIO(5), VAV1(2), WASF1(2) 15373550 50 44 49 14 1 5 15 21 8 0 0.34 1.00 1.00 360 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(1), AKT1(1), CAMK2D(1), CAMK2G(2), GNAS(3), MAPK1(1), MAPK14(1), MAPK3(1), PIK3CA(14), PIK3R1(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), RPS6KA1(2), SOS1(4) 12782134 38 36 37 11 4 3 13 17 1 0 0.42 1.00 1.00 361 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(3), CD19(1), CD1A(1), CD1D(1), CD1E(1), CD22(1), CD33(1), CD34(2), CD38(1), CD3E(1), CD3G(1), CD4(1), CD44(2), CD55(2), CD7(1), CD8B(1), CR1(11), CR2(1), CSF1R(2), CSF2RA(2), CSF3R(1), DNTT(2), FCER2(1), FCGR1A(1), FLT3(2), HLA-DRA(1), IL1R2(1), IL2RA(2), IL3(1), IL3RA(1), IL4R(2), IL7R(1), IL9R(3), ITGA1(4), ITGA2(3), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(2), ITGAM(1), KITLG(2), MME(1), TFRC(2), TPO(2) 36006114 78 68 75 20 5 4 21 35 13 0 0.28 1.00 1.00 362 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(1), AGTR2(1), AVPR1A(2), AVPR2(1), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(1), CCKBR(1), CCR4(1), CCR6(1), CX3CR1(1), CXCR4(1), CXCR6(2), EDNRB(1), FPR1(2), GALR1(1), GALT(2), GPR77(1), LHCGR(1), MC2R(2), MC3R(1), MC4R(1), NPY2R(1), NTSR1(1), OPRD1(3), OPRL1(2), OPRM1(3), SSTR1(1), SSTR3(1), SSTR4(1), TACR1(1), TACR3(3), TRHR(2) 22939122 48 44 48 13 11 6 12 16 3 0 0.16 1.00 1.00 363 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(1), AKT2(2), AKT3(2), BLNK(2), CD19(1), CSK(2), EPHB2(1), ITPKA(1), ITPKB(2), LYN(1), MAP2K1(1), MAPK1(1), NFAT5(3), NFKBIL2(2), PIK3CA(14), PIK3CD(1), PIK3R1(1), PLCG2(2), PPP1R13B(3), SHC1(2), SOS1(4), SOS2(1), SYK(1), VAV1(2) 23166965 53 46 52 14 7 5 18 19 4 0 0.16 1.00 1.00 364 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(4), ATP6V0A1(3), ATP6V0A4(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(2), ATP7B(4), COX7A2(1), NDUFA10(1), NDUFA8(1), NDUFB6(1), NDUFS1(3), NDUFS2(1), PPA2(1), SDHA(1), SDHB(1), SHMT1(2), UQCRFS1(3) 16804824 34 32 32 10 3 1 12 15 3 0 0.43 1.00 1.00 365 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), ABP1(4), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AOC2(1), AOC3(1), AOX1(4), CAT(2), CYP1A1(1), CYP1A2(2), DDC(3), ECHS1(1), EHHADH(2), GCDH(1), HADH(1), HADHA(1), HSD17B4(1), INMT(1), LCMT1(1), LCMT2(2), MAOA(1), MAOB(1), METTL6(1), NFX1(3), OGDH(1), OGDHL(2), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(1), TPH1(3), WARS2(2) 26709962 59 50 59 15 6 5 20 23 5 0 0.14 1.00 1.00 366 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(2), DAXX(4), ELK1(1), MAP3K1(3), MAP3K5(4), MAP3K7(2), MAP3K9(1), MAPK14(1), MAX(3), MEF2A(2), MEF2C(2), MEF2D(1), MKNK1(1), RIPK1(2), SHC1(2), STAT1(2), TGFB2(1), TRADD(1) 16188327 36 33 36 11 3 3 8 15 7 0 0.51 1.00 1.00 367 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(2), CALM2(1), CAMK1(1), ELK1(1), FPR1(2), GNB1(2), MAP2K1(1), MAP2K3(2), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), NCF1(1), NCF2(1), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), PAK1(1), PIK3C2G(1), PLCB1(1), PPP3CB(1), PPP3CC(2), RELA(1), SYT1(1) 16959508 36 32 36 11 6 3 9 10 8 0 0.48 1.00 1.00 368 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACADM(1), ACADS(2), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AOX1(4), AUH(1), BCKDHA(1), DBT(1), DLD(4), ECHS1(1), EHHADH(2), HADH(1), HADHA(1), HADHB(1), HIBADH(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), IVD(1), MCCC1(2), MCCC2(4), MCEE(1), MUT(2), OXCT1(1), PCCA(2), PCCB(2) 18939851 46 43 45 14 6 3 12 18 7 0 0.36 1.00 1.00 369 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(2), COL4A3(2), COL4A4(3), COL4A5(7), COL4A6(5), F11(1), F12(1), F2(2), F5(5), F8(4), FGA(2), FGB(1), FGG(2), KLKB1(1), PROC(2), PROS1(5), SERPING1(2) 19769733 47 43 47 16 8 1 16 14 8 0 0.48 1.00 1.00 370 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2A2(1), GTF2E2(2), GTF2F1(1), GTF2F2(1), GTF2H1(1), GTF2I(1), GTF2IRD1(1), TAF1(6), TAF1L(7), TAF2(1), TAF4(1), TAF4B(3), TAF5(2), TAF5L(2), TAF7L(3), TAF9(1), TAF9B(2) 15853515 37 34 37 11 6 4 7 18 2 0 0.42 1.00 1.00 371 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(2), POLB(2), POLD1(3), POLD2(1), POLD3(1), POLE(4), POLG(2), POLG2(4), POLH(1), POLI(2), POLK(2), POLL(1), POLM(1), POLQ(6), PRIM1(1), PRIM2(5), REV1(1), REV3L(5) 18076548 44 42 43 12 6 2 9 17 8 2 0.46 1.00 1.00 372 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(1), AKT2(2), AKT3(2), BCL10(1), BLNK(2), CARD11(3), CD19(1), CD22(1), CR2(1), GSK3B(1), IKBKB(1), INPP5D(1), JUN(1), KRAS(4), LILRB3(3), LYN(1), MALT1(2), NFAT5(3), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), NRAS(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PLCG2(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PTPN6(1), RAC3(1), SYK(1), VAV1(2), VAV2(3), VAV3(2) 32830158 82 70 81 22 5 6 29 31 11 0 0.16 1.00 1.00 373 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(1), CABIN1(4), CALM1(2), CALM2(1), CAMK1(1), IGF1(1), IGF1R(1), INSR(2), MAPK14(1), MAPK7(1), MEF2A(2), MEF2C(2), MEF2D(1), NFATC1(1), NFATC2(2), PIK3CA(14), PIK3R1(1), PPP3CB(1), PPP3CC(2), SYT1(1) 15337753 42 39 41 14 5 4 13 16 4 0 0.50 1.00 1.00 374 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(1), ABAT(1), ACADS(2), ACSM1(1), AKR1B10(3), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), BDH1(1), BDH2(1), DDHD1(1), ECHS1(1), EHHADH(2), GAD1(1), HADH(1), HADHA(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), ILVBL(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHB(1), PRDX6(1), RDH11(2) 17884292 34 33 33 11 6 3 8 11 6 0 0.43 1.00 1.00 375 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(4), ATP4A(2), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP6V0A1(3), ATP6V0A4(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(2), COX15(1), COX17(1), COX4I2(1), COX7A2(1), NDUFA10(1), NDUFA13(3), NDUFA8(1), NDUFB11(1), NDUFB6(1), NDUFS1(3), NDUFS2(1), NDUFS3(2), NDUFS4(2), NDUFS5(1), NDUFS8(1), PPA2(1), SDHA(1), SDHB(1), SDHD(1), UQCRC2(1), UQCRFS1(3) 24558703 54 50 52 16 6 3 13 25 7 0 0.42 1.00 1.00 376 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(7), ACACB(4), ACADM(1), ACSS1(2), ACSS2(3), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1), LDHAL6B(1), LDHB(1), LDHC(2), MCEE(1), MLYCD(1), MUT(2), PCCA(2), PCCB(2), SUCLG1(2), SUCLG2(1) 17424222 43 41 43 14 4 5 17 9 8 0 0.38 1.00 1.00 377 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(1), AKT2(2), AKT3(2), BLNK(2), CD19(1), CD22(1), CR2(1), CSK(2), GSK3A(1), GSK3B(1), INPP5D(1), ITPR1(2), ITPR2(7), ITPR3(1), LYN(1), MAPK1(1), MAPK3(1), NFATC1(1), NFATC2(2), PDK1(1), PIK3CA(14), PIK3CD(1), PIK3R1(1), PLCG2(2), PPP1R13B(3), PPP3CB(1), PPP3CC(2), PTPRC(6), SHC1(2), SOS1(4), SOS2(1), SYK(1), VAV1(2) 32650819 72 60 71 19 10 6 22 26 8 0 0.16 1.00 1.00 378 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), ARSE(1), CYP11B2(2), CYP19A1(3), HSD17B1(1), HSD17B7(2), HSD17B8(1), HSD3B1(1), LCMT1(1), LCMT2(2), METTL6(1), PRMT3(2), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(1), SRD5A1(1), STS(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2A1(3), UGT2A3(4), UGT2B10(7), UGT2B11(2), UGT2B15(1), UGT2B7(2) 22214932 58 50 55 18 6 7 16 24 5 0 0.37 1.00 1.00 379 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BCL2A1(2), CASP1(1), CASP10(2), CASP2(2), CASP4(1), CASP7(1), DAXX(4), FAS(3), IKBKE(1), LTA(1), NGFR(1), NTRK1(2), PTPN13(7), RIPK1(2), SFRS2IP(6), TNFRSF1A(2), TRADD(1), TRAF6(1) 19399869 41 37 41 13 2 2 12 20 5 0 0.58 1.00 1.00 380 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTG1(4), ACTN1(2), ACTN2(2), ACTN3(1), ACTN4(2), AKT1(1), AKT2(2), AKT3(2), ARHGAP5(3), BCAR1(2), BIRC2(2), BIRC3(2), BRAF(5), CAPN2(1), CCND2(1), CDC42(2), CHAD(2), COL11A1(8), COL11A2(1), COL1A1(1), COL1A2(7), COL2A1(5), COL3A1(1), COL4A1(2), COL4A4(3), COL4A6(5), COL5A1(1), COL5A2(3), COL5A3(8), COL6A2(5), COL6A3(11), COL6A6(9), CTNNB1(2), DOCK1(5), EGF(3), EGFR(4), ELK1(1), ERBB2(3), FIGF(2), FLNA(3), FLNB(2), FLNC(6), FLT1(3), FN1(6), FYN(1), GRLF1(3), GSK3B(1), HGF(1), IGF1(1), IGF1R(1), ITGA1(4), ITGA10(2), ITGA11(3), ITGA2(3), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(2), ITGB1(2), ITGB5(2), ITGB6(3), ITGB8(1), JUN(1), KDR(5), LAMA1(8), LAMA2(8), LAMA3(2), LAMA4(5), LAMA5(4), LAMB1(2), LAMB2(2), LAMB4(6), LAMC1(3), LAMC2(5), LAMC3(5), MAP2K1(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(1), MAPK9(1), MET(5), MYL2(1), MYL7(1), MYL9(1), MYLK(3), MYLK2(2), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PARVG(1), PDGFA(1), PDGFD(1), PDGFRA(6), PGF(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PIP5K1C(1), PPP1CB(1), PPP1R12A(4), PRKCG(1), PTEN(16), PTK2(1), PXN(2), RAC3(1), RAP1B(2), RAPGEF1(1), RELN(5), ROCK1(3), ROCK2(3), SHC1(2), SHC2(1), SOS1(4), SOS2(1), SPP1(1), SRC(1), THBS1(5), THBS2(2), THBS3(3), THBS4(1), TLN1(6), TLN2(7), TNC(3), TNN(1), TNR(5), TNXB(2), VAV1(2), VAV2(3), VAV3(2), VCL(1), VTN(1), VWF(6), ZYX(1) 164122610 408 202 406 145 40 28 128 151 61 0 0.55 1.00 1.00 381 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(1), ADCY2(1), ADCY3(1), ADCY8(5), ADCY9(3), ADORA2A(3), ADRA1A(1), ADRB2(1), AGTR1(1), ATP2A1(2), ATP2A2(2), ATP2B1(2), ATP2B2(1), AVPR1A(2), BDKRB1(1), BDKRB2(1), CACNA1A(1), CACNA1B(3), CACNA1C(8), CACNA1D(6), CACNA1E(3), CACNA1F(4), CACNA1G(4), CACNA1H(2), CACNA1I(2), CACNA1S(8), CALM1(2), CALM2(1), CAMK2D(1), CAMK2G(2), CCKAR(1), CCKBR(1), CD38(1), CHRM2(3), CHRM3(2), CHRM5(1), CYSLTR1(1), DRD1(1), EDNRB(1), EGFR(4), ERBB2(3), ERBB3(5), ERBB4(7), GNA11(1), GNA14(1), GNAS(3), GRIN1(2), GRIN2A(3), GRM1(4), GRM5(3), HTR2A(2), HTR2C(1), HTR5A(1), HTR7(1), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(1), LHCGR(1), MYLK(3), MYLK2(2), NOS1(7), NOS3(1), NTSR1(1), P2RX1(2), P2RX2(2), P2RX3(1), PDE1B(2), PDE1C(2), PDGFRA(6), PHKA1(2), PHKA2(1), PHKB(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCD4(2), PLCE1(3), PLCG2(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKACA(1), PRKACB(1), PRKACG(2), PRKCG(1), PRKX(1), PTGFR(1), PTK2B(2), RYR1(12), RYR2(12), RYR3(14), SLC25A4(1), SLC25A6(1), SLC8A1(3), SLC8A2(1), SLC8A3(3), SPHK2(1), TACR1(1), TACR3(3), TBXA2R(1), TRHR(2), TRPC1(2), VDAC2(1), VDAC3(1) 119265408 261 176 261 106 44 17 62 114 24 0 0.94 1.00 1.00 382 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(3), ACVR1C(2), AKT1(1), AKT2(2), AKT3(2), ATF2(1), BRAF(5), CACNA1A(1), CACNA1B(3), CACNA1C(8), CACNA1D(6), CACNA1E(3), CACNA1F(4), CACNA1G(4), CACNA1H(2), CACNA1I(2), CACNA1S(8), CACNA2D1(2), CACNA2D4(2), CACNB2(1), CACNG3(2), CACNG6(1), CACNG7(1), CACNG8(1), CDC42(2), DAXX(4), DUSP10(1), DUSP14(1), DUSP5(1), DUSP7(1), DUSP9(1), ECSIT(1), EGF(3), EGFR(4), ELK1(1), ELK4(2), FAS(3), FGF13(1), FGF14(1), FGF20(1), FGF23(1), FGF3(1), FGF5(1), FGF6(1), FGF9(1), FGFR1(4), FGFR2(4), FGFR3(1), FGFR4(2), FLNA(3), FLNB(2), FLNC(6), IKBKB(1), IL1R2(1), JUN(1), KRAS(4), MAP2K1(1), MAP2K3(2), MAP2K7(1), MAP3K1(3), MAP3K10(2), MAP3K12(1), MAP3K13(1), MAP3K14(1), MAP3K2(2), MAP3K4(5), MAP3K5(4), MAP3K6(2), MAP3K7(2), MAP4K3(2), MAP4K4(2), MAPK1(1), MAPK10(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MAPT(2), MAX(3), MEF2C(2), MKNK1(1), MKNK2(2), MRAS(1), NF1(11), NFATC2(2), NFATC4(2), NR4A1(1), NRAS(1), NTRK1(2), NTRK2(1), PAK1(1), PAK2(2), PDGFA(1), PDGFRA(6), PLA2G12A(1), PLA2G6(1), PPM1B(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PPP5C(1), PRKACA(1), PRKACB(1), PRKACG(2), PRKCG(1), PRKX(1), PTPN5(1), PTPN7(1), PTPRR(2), RAC3(1), RAP1B(2), RAPGEF2(8), RASA1(2), RASA2(1), RASGRF1(3), RASGRF2(2), RASGRP2(2), RASGRP4(2), RPS6KA1(2), RPS6KA2(1), RPS6KA6(3), SOS1(4), SOS2(1), STK3(1), TAOK3(1), TGFB2(1), TGFBR2(1), TNFRSF1A(2), TP53(13), TRAF6(1), ZAK(2) 126754339 290 173 290 113 34 18 80 117 41 0 0.89 1.00 1.00 383 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(2), ACTN1(2), ACTN2(2), ACTN3(1), ACTN4(2), APC(6), APC2(4), ARHGEF1(1), ARHGEF12(2), ARHGEF6(1), ARHGEF7(2), ARPC2(1), ARPC3(1), BCAR1(2), BDKRB1(1), BDKRB2(1), BRAF(5), CDC42(2), CHRM2(3), CHRM3(2), CHRM5(1), CSK(2), CYFIP1(1), CYFIP2(2), DIAPH2(4), DIAPH3(1), DOCK1(5), EGF(3), EGFR(4), F2(2), FGD1(1), FGF13(1), FGF14(1), FGF20(1), FGF23(1), FGF3(1), FGF5(1), FGF6(1), FGF9(1), FGFR1(4), FGFR2(4), FGFR3(1), FGFR4(2), FN1(6), GNA13(2), GRLF1(3), GSN(1), IQGAP1(2), IQGAP2(2), IQGAP3(1), ITGA1(4), ITGA10(2), ITGA11(3), ITGA2(3), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(2), ITGAD(2), ITGAE(3), ITGAL(3), ITGAM(1), ITGAX(2), ITGB1(2), ITGB2(1), ITGB5(2), ITGB6(3), ITGB8(1), KRAS(4), LIMK1(2), LIMK2(1), MAP2K1(1), MAPK1(1), MAPK3(1), MRAS(1), MSN(4), MYH10(1), MYH14(2), MYH9(2), MYL2(1), MYL7(1), MYL9(1), MYLK(3), MYLK2(2), NCKAP1(2), NCKAP1L(1), NRAS(1), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PDGFA(1), PDGFRA(6), PFN4(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PIP4K2A(1), PIP4K2C(1), PIP5K1C(1), PPP1CB(1), PPP1R12A(4), PPP1R12B(1), PTK2(1), PXN(2), RAC3(1), RDX(1), ROCK1(3), ROCK2(3), SCIN(1), SLC9A1(2), SOS1(4), SOS2(1), SSH1(3), SSH2(3), SSH3(1), TIAM1(2), TIAM2(1), VAV1(2), VAV2(3), VAV3(2), VCL(1), WASF1(2), WASF2(1), WASL(5) 122465623 277 169 276 114 25 25 87 110 30 0 0.93 1.00 1.00 384 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTG1(4), CHAD(2), COL11A1(8), COL11A2(1), COL17A1(1), COL1A1(1), COL1A2(7), COL2A1(5), COL3A1(1), COL4A1(2), COL4A4(3), COL4A6(5), COL5A1(1), COL5A2(3), COL5A3(8), COL6A2(5), COL6A3(11), COL6A6(9), DSC1(1), DSC2(1), DSC3(1), DSG1(5), DSG2(1), DSG3(1), DSG4(2), FN1(6), GJA10(1), GJA3(1), GJA5(1), GJA8(1), GJA9(2), GJB3(1), GJB6(2), GJC1(1), GJC2(1), GJD2(2), ITGA6(2), KRT1(5), KRT12(1), KRT13(2), KRT15(1), KRT16(1), KRT2(2), KRT23(1), KRT24(1), KRT27(1), KRT28(1), KRT3(1), KRT31(2), KRT36(2), KRT39(2), KRT4(3), KRT5(1), KRT6B(2), KRT6C(1), KRT7(1), KRT71(1), KRT74(1), KRT75(2), KRT78(1), KRT79(2), KRT82(2), KRT84(1), KRT85(2), KRT9(1), LAMA1(8), LAMA2(8), LAMA3(2), LAMA4(5), LAMA5(4), LAMB1(2), LAMB2(2), LAMB4(6), LAMC1(3), LAMC2(5), LAMC3(5), LMNA(1), NES(2), PRPH(1), RELN(5), SPP1(1), THBS1(5), THBS2(2), THBS3(3), THBS4(1), TNC(3), TNN(1), TNR(5), TNXB(2), VIM(1), VTN(1), VWF(6) 109843946 244 160 240 86 35 10 66 95 38 0 0.56 1.00 1.00 385 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADORA2A(3), ADORA3(1), ADRA1A(1), ADRB2(1), AGTR1(1), AGTR2(1), AVPR1A(2), AVPR2(1), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(1), CCKBR(1), CHRM2(3), CHRM3(2), CHRM5(1), CNR1(1), CNR2(1), CRHR2(1), CYSLTR1(1), DRD1(1), DRD2(1), DRD3(1), DRD5(3), EDNRB(1), F2(2), F2RL2(1), FPR1(2), GABBR1(1), GABRA1(1), GABRA3(1), GABRA4(3), GABRA5(2), GABRA6(1), GABRB1(1), GABRB3(1), GABRD(1), GABRE(3), GABRG1(1), GABRG2(4), GABRQ(4), GABRR1(2), GABRR2(1), GALR1(1), GH1(1), GH2(1), GHR(1), GHRHR(1), GIPR(1), GLP1R(1), GLRA2(2), GPR35(1), GPR50(1), GPR63(1), GPR83(2), GRIA1(4), GRIA2(1), GRIA3(1), GRIA4(2), GRID1(3), GRID2(5), GRIK1(2), GRIK2(4), GRIK3(2), GRIK5(3), GRIN1(2), GRIN2A(3), GRIN2B(10), GRIN3A(1), GRIN3B(2), GRM1(4), GRM2(2), GRM3(2), GRM4(2), GRM5(3), GRM6(1), GRM7(1), GZMA(1), HCRTR2(1), HRH4(1), HTR1A(2), HTR1E(3), HTR2A(2), HTR2C(1), HTR5A(1), HTR7(1), LEPR(1), LHCGR(1), LTB4R(1), MAS1(1), MC2R(2), MC3R(1), MC4R(1), MCHR2(2), MTNR1B(1), NMUR2(2), NPBWR1(1), NPBWR2(1), NPFFR2(3), NPY2R(1), NTSR1(1), OPRD1(3), OPRL1(2), OPRM1(3), P2RX1(2), P2RX2(2), P2RX3(1), P2RY10(1), P2RY13(1), P2RY14(1), P2RY2(1), P2RY6(1), P2RY8(1), PARD3(3), PRLR(2), PTGER2(1), PTGFR(1), PTGIR(1), RXFP1(1), SCTR(1), SSTR1(1), SSTR3(1), SSTR4(1), TAAR1(1), TAAR2(1), TAAR9(1), TACR1(1), TACR3(3), TBXA2R(1), THRA(3), TRHR(2), VIPR1(1), VIPR2(1) 97456328 220 153 220 70 35 20 54 96 15 0 0.36 1.00 1.00 386 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(4), CD44(2), CHAD(2), COL11A1(8), COL11A2(1), COL1A1(1), COL1A2(7), COL2A1(5), COL3A1(1), COL4A1(2), COL4A4(3), COL4A6(5), COL5A1(1), COL5A2(3), COL5A3(8), COL6A2(5), COL6A3(11), COL6A6(9), FN1(6), FNDC1(3), FNDC3A(2), HMMR(2), HSPG2(9), ITGA1(4), ITGA10(2), ITGA11(3), ITGA2(3), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(2), ITGB1(2), ITGB5(2), ITGB6(3), ITGB8(1), LAMA1(8), LAMA2(8), LAMA3(2), LAMA4(5), LAMA5(4), LAMB1(2), LAMB2(2), LAMB4(6), LAMC1(3), LAMC2(5), LAMC3(5), RELN(5), SPP1(1), SV2C(3), THBS1(5), THBS2(2), THBS3(3), THBS4(1), TNC(3), TNN(1), TNR(5), TNXB(2), VTN(1), VWF(6) 99344543 220 153 219 78 28 12 64 83 33 0 0.52 1.00 1.00 387 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTG1(4), ACTN1(2), ACTN2(2), ACTN3(1), ACTN4(2), AKT1(1), AKT2(2), AKT3(2), AMOTL1(1), ASH1L(8), CDC42(2), CDK4(1), CGN(1), CLDN10(3), CLDN16(1), CLDN18(2), CLDN22(1), CLDN4(1), CLDN7(1), CSDA(3), CTNNA1(4), CTNNA2(3), CTNNA3(3), CTNNB1(2), EPB41L1(1), EPB41L2(1), EPB41L3(4), EXOC4(2), F11R(1), GNAI1(2), GNAI2(1), HCLS1(1), INADL(5), JAM2(1), KRAS(4), LLGL1(2), LLGL2(1), MAGI1(2), MAGI2(5), MAGI3(4), MLLT4(7), MPDZ(3), MPP5(1), MRAS(1), MYH1(9), MYH10(1), MYH11(3), MYH13(5), MYH14(2), MYH15(2), MYH2(6), MYH3(5), MYH4(7), MYH6(2), MYH7(3), MYH7B(1), MYH8(4), MYH9(2), MYL2(1), MYL7(1), MYL9(1), NRAS(1), PARD3(3), PARD6B(3), PPM1J(1), PPP2CA(1), PPP2CB(1), PPP2R1B(1), PPP2R2A(1), PPP2R2B(3), PPP2R3A(1), PPP2R4(1), PRKCD(1), PRKCE(4), PRKCG(1), PRKCH(3), PRKCI(3), PRKCQ(1), PTEN(16), SPTAN1(3), SRC(1), TJAP1(1), TJP1(4), TJP2(2), TJP3(1), YES1(1), ZAK(2) 85606176 218 144 216 84 28 11 57 82 40 0 0.90 1.00 1.00 388 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(1), ADCY2(1), ADCY3(1), ADCY5(3), ADCY6(2), ADCY8(5), ADCY9(3), ADRA1A(1), ADRB2(1), ANXA6(1), ATP1A4(3), ATP2A2(2), ATP2B1(2), ATP2B2(1), CACNA1A(1), CACNA1B(3), CACNA1C(8), CACNA1D(6), CACNA1E(3), CACNA1S(8), CALM1(2), CALM2(1), CALR(1), CAMK1(1), CAMK2D(1), CAMK2G(2), CASQ1(1), CASQ2(1), CHRM2(3), CHRM3(2), CHRM5(1), GJA5(1), GJB3(1), GJB6(2), GNA11(1), GNAI2(1), GNAO1(1), GNB1(2), GNB4(1), GNB5(1), GNG3(1), GRK4(1), GRK6(3), ITPR1(2), ITPR2(7), ITPR3(1), KCNB1(1), KCNJ3(3), MIB1(2), MYCBP(1), NME7(1), PLCB3(1), PRKACA(1), PRKACB(1), PRKAR1A(1), PRKAR2B(2), PRKCD(1), PRKCE(4), PRKCG(1), PRKCH(3), PRKCQ(1), PRKD1(4), RGS11(1), RGS18(1), RGS2(1), RGS3(4), RGS4(1), RGS6(2), RGS7(1), RGS9(2), RYR1(12), RYR2(12), RYR3(14), SLC8A1(3), SLC8A3(3), USP5(1) 83356100 184 135 182 62 32 13 42 77 20 0 0.50 1.00 1.00 389 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(3), ABLIM1(1), ABLIM3(3), ARHGEF12(2), CDC42(2), CXCR4(1), DCC(4), EFNB2(1), EPHA1(1), EPHA4(1), EPHA5(4), EPHA6(2), EPHA7(5), EPHA8(4), EPHB1(1), EPHB2(1), EPHB3(1), EPHB4(3), EPHB6(4), FES(2), FYN(1), GNAI1(2), GNAI2(1), GSK3B(1), ITGB1(2), KRAS(4), L1CAM(3), LIMK1(2), LIMK2(1), MAPK1(1), MAPK3(1), MET(5), NFAT5(3), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), NGEF(1), NRAS(1), NRP1(3), NTN4(2), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PLXNA1(2), PLXNA2(4), PLXNA3(1), PLXNB1(3), PLXNB2(2), PLXNC1(4), PPP3CB(1), PPP3CC(2), PPP3R1(1), PTK2(1), RAC3(1), RASA1(2), RGS3(4), RND1(2), ROBO1(4), ROBO2(2), ROBO3(1), ROCK1(3), ROCK2(3), SEMA3A(1), SEMA3C(1), SEMA3D(2), SEMA3E(3), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4D(1), SEMA4F(1), SEMA4G(2), SEMA5A(1), SEMA6D(3), SLIT1(2), SLIT2(5), SLIT3(5), SRGAP1(3), SRGAP2(1), SRGAP3(2), UNC5A(2), UNC5B(1), UNC5C(1), UNC5D(2) 87091410 182 133 182 78 19 12 53 81 17 0 0.96 1.00 1.00 390 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(8), ASH2L(2), C17orf79(1), CTCFL(2), DOT1L(3), EED(1), EHMT1(1), EHMT2(2), EZH2(4), FBXO11(1), HCFC1(3), HSF4(2), JMJD4(1), JMJD6(3), KDM6A(3), MEN1(1), MLL(5), MLL2(9), MLL3(20), MLL4(4), MLL5(8), NSD1(5), OGT(3), PPP1CB(1), PRDM9(3), PRMT5(3), PRMT6(1), PRMT7(2), PRMT8(1), RBBP5(3), SETD1A(1), SETD2(36), SETDB1(3), SETMAR(1), SUV39H2(3), SUV420H1(2), SUZ12(3), WHSC1(3), WHSC1L1(4) 52455702 162 123 160 48 12 16 35 48 50 1 0.35 1.00 1.00 391 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 251 ACVR1B(3), ACVR2A(3), ACVR2B(1), AMHR2(2), BMP7(1), BMPR1B(1), BMPR2(4), CCL2(1), CCL27(1), CCL28(1), CCR4(1), CCR6(1), CD27(1), CNTF(1), CSF1R(2), CSF2RA(2), CSF2RB(1), CSF3R(1), CX3CR1(1), CXCL11(1), CXCR4(1), CXCR6(2), EDA(2), EGF(3), EGFR(4), FAS(3), FLT1(3), FLT3(2), FLT4(4), GDF5(1), GH1(1), GH2(1), GHR(1), HGF(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR1(1), IFNAR2(1), IFNGR1(1), IFNW1(1), IL12RB2(1), IL15(1), IL17RB(1), IL18RAP(3), IL19(2), IL1R2(1), IL1RAP(2), IL20RA(1), IL21(1), IL21R(2), IL23A(1), IL23R(1), IL25(1), IL26(1), IL28A(1), IL28B(1), IL2RA(2), IL2RB(1), IL3(1), IL3RA(1), IL4R(2), IL6ST(3), IL7R(1), IL9R(3), INHBA(1), KDR(5), KITLG(2), LEPR(1), LIFR(2), LTA(1), LTBR(2), MET(5), MPL(1), NGFR(1), OSMR(1), PDGFRA(6), PF4(1), PLEKHO2(1), PRLR(2), RELT(1), TGFB2(1), TGFBR2(1), TNFRSF10A(1), TNFRSF11B(1), TNFRSF14(1), TNFRSF1A(2), TNFRSF4(1), TNFRSF9(1), TNFSF11(1), TNFSF14(2), TPO(2), XCL1(1), XCR1(1) 78281016 154 117 154 51 11 6 48 80 9 0 0.55 1.00 1.00 392 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(6), APC2(4), AXIN1(1), AXIN2(1), CACYBP(1), CAMK2D(1), CAMK2G(2), CCND2(1), CHD8(5), CREBBP(4), CSNK1A1(1), CSNK1E(2), CTBP1(1), CTNNB1(2), CUL1(3), DAAM1(3), DKK1(1), DVL1(1), EP300(6), FBXW11(1), FZD1(2), FZD10(2), FZD2(1), FZD3(1), FZD4(1), FZD5(1), FZD6(1), GSK3B(1), JUN(1), LEF1(1), LRP5(2), LRP6(3), MAP3K7(2), MAPK10(2), MAPK8(1), MAPK9(1), NFAT5(3), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), NKD1(2), NKD2(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PORCN(1), PPP2CA(1), PPP2CB(1), PPP2R1B(1), PPP2R2A(1), PPP2R2B(3), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRICKLE1(2), PRKACA(1), PRKACB(1), PRKACG(2), PRKCG(1), PRKX(1), RAC3(1), ROCK1(3), ROCK2(3), RUVBL1(1), SFRP1(2), SFRP4(2), SMAD2(3), SMAD4(3), TBL1X(1), TBL1XR1(3), TBL1Y(1), TCF7(2), TCF7L2(1), TP53(13), VANGL1(2), WNT16(1), WNT2(2), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1), WNT9A(1) 71394046 159 117 157 77 12 12 51 63 21 0 0.99 1.00 1.00 393 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(3), ANAPC1(4), ANAPC11(1), ANAPC2(1), ANAPC4(2), ANAPC5(2), ANAPC7(1), ATM(15), ATR(5), BUB1(2), BUB1B(1), BUB3(1), CCNA1(1), CCNB2(5), CCNB3(4), CCND2(1), CCNE1(1), CCNH(1), CDC14A(4), CDC16(2), CDC20(1), CDC23(2), CDC25A(1), CDC25C(2), CDC27(5), CDC6(1), CDC7(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(3), CDKN2C(1), CHEK1(1), CHEK2(7), CREBBP(4), CUL1(3), EP300(6), ESPL1(6), FZR1(1), GSK3B(1), HDAC1(1), MAD2L1(1), MCM2(3), MCM5(1), MCM6(1), MCM7(6), ORC1L(2), ORC3L(1), ORC4L(1), ORC5L(1), ORC6L(1), PCNA(2), PRKDC(5), RB1(2), RBL2(3), SKP2(1), SMAD2(3), SMAD4(3), SMC1A(1), SMC1B(3), TGFB2(1), TP53(13), YWHAE(2) 60407937 164 116 161 75 10 17 53 58 26 0 0.97 1.00 1.00 394 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(1), AKT2(2), AKT3(2), CBL(2), CBLB(3), CBLC(1), CCND2(1), CNTF(1), CREBBP(4), CSF2RA(2), CSF2RB(1), CSF3R(1), EP300(6), GH1(1), GH2(1), GHR(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR1(1), IFNAR2(1), IFNGR1(1), IFNW1(1), IL12RB2(1), IL15(1), IL19(2), IL20RA(1), IL21(1), IL21R(2), IL23A(1), IL23R(1), IL26(1), IL28A(1), IL28B(1), IL2RA(2), IL2RB(1), IL3(1), IL3RA(1), IL4R(2), IL6ST(3), IL7R(1), IL9R(3), IRF9(2), JAK1(4), JAK2(5), JAK3(2), LEPR(1), LIFR(2), MPL(1), OSMR(1), PIAS1(2), PIAS3(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PRLR(2), PTPN11(1), PTPN6(1), SOCS4(1), SOS1(4), SOS2(1), SPRED1(4), SPRED2(1), SPRY2(2), SPRY4(1), STAM(2), STAT1(2), STAT2(3), STAT3(1), STAT4(2), STAT5A(2), STAT6(1), TPO(2), TYK2(3) 64029997 151 116 150 49 11 10 53 65 12 0 0.42 1.00 1.00 395 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(1), ADCY2(1), ADCY3(1), ADCY5(3), ADCY6(2), ADCY8(5), ADCY9(3), ATF1(1), ATF2(1), ATP2A2(2), CALM1(2), CALM2(1), CAMK2D(1), CAMK2G(2), CORIN(1), DGKZ(2), GABPA(1), GBA2(2), GNB1(2), GNB4(1), GNB5(1), GNG3(1), GRK4(1), GRK6(3), GUCY1A3(2), IGFBP4(1), IGFBP6(1), ITPR1(2), ITPR2(7), ITPR3(1), JUN(1), MIB1(2), MYL2(1), MYLK2(2), NOS1(7), NOS3(1), PDE4B(1), PDE4D(1), PLCB3(1), PLCD1(1), PLCG2(2), PRKACA(1), PRKACB(1), PRKAR1A(1), PRKAR2B(2), PRKCD(1), PRKCE(4), PRKCH(3), PRKCQ(1), PRKD1(4), RAMP1(1), RGS11(1), RGS18(1), RGS2(1), RGS3(4), RGS4(1), RGS6(2), RGS7(1), RGS9(2), RYR1(12), RYR2(12), RYR3(14), SLC8A1(3), SP1(1), TNXB(2), USP5(1) 76811484 152 116 150 61 23 6 42 64 17 0 0.90 1.00 1.00 396 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(7), ACACB(4), AKT1(1), AKT2(2), AKT3(2), BRAF(5), CALM1(2), CALM2(1), CBL(2), CBLB(3), CBLC(1), ELK1(1), EXOC7(1), FASN(3), FOXO1(1), G6PC(1), GSK3B(1), GYS1(2), GYS2(1), IKBKB(1), INPP5D(1), INSR(2), IRS1(3), IRS2(1), KRAS(4), LIPE(4), MAP2K1(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(1), MAPK9(1), MKNK1(1), MKNK2(2), NRAS(1), PCK1(2), PCK2(2), PDE3A(3), PDE3B(3), PFKL(2), PFKM(1), PHKA1(2), PHKA2(1), PHKB(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PPARGC1A(1), PPP1CB(1), PPP1R3A(4), PPP1R3D(1), PRKAA1(1), PRKACA(1), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAG2(1), PRKAR1A(1), PRKAR2B(2), PRKCI(3), PRKX(1), PTPN1(1), PTPRF(2), PYGB(1), PYGL(1), PYGM(2), RAPGEF1(1), RHEB(2), RHOQ(1), RPS6KB1(2), RPS6KB2(1), SH2B2(1), SHC1(2), SHC2(1), SOCS4(1), SORBS1(1), SOS1(4), SOS2(1), SREBF1(1), TSC1(4), TSC2(2) 70765460 164 115 163 44 17 13 48 65 21 0 0.089 1.00 1.00 397 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTN2(2), ACTN3(1), ACTN4(2), DMD(9), FAM48A(1), MYBPC1(2), MYBPC2(2), MYBPC3(1), MYH3(5), MYH6(2), MYH7(3), MYH8(4), MYL2(1), MYL9(1), MYOM1(5), NEB(12), TMOD1(2), TNNI1(1), TNNI3(1), TNNT1(3), TNNT3(1), TPM2(1), TTN(98), VIM(1) 60975040 161 113 161 48 19 11 50 62 19 0 0.24 1.00 1.00 398 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(3), ACTN1(2), ACTR2(2), ACTR3(1), AKT1(1), AKT2(2), AKT3(2), ARHGEF6(1), ARHGEF7(2), BCAR1(2), BRAF(5), CDC42(2), CDKN2A(3), CSE1L(1), DOCK1(5), EPHB2(1), FYN(1), GRB7(2), GRLF1(3), ITGA1(4), ITGA10(2), ITGA11(3), ITGA2(3), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(2), MAP2K7(1), MAP3K11(1), MAPK1(1), MAPK10(2), MAPK8(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MRAS(1), MYLK(3), MYLK2(2), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PIK3CA(14), PIK3CB(2), PLCG2(2), PTEN(16), PTK2(1), ROCK1(3), ROCK2(3), SHC1(2), SOS1(4), SOS2(1), SRC(1), TLN1(6), TLN2(7), ZYX(1) 54051301 152 111 151 48 7 15 55 55 20 0 0.27 1.00 1.00 399 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(1), CADM1(2), CADM3(2), CD22(1), CD274(2), CD28(2), CD34(2), CD4(1), CD6(2), CD80(1), CD86(1), CD8B(1), CD99(1), CDH1(3), CDH15(1), CDH2(3), CDH3(2), CDH4(2), CDH5(2), CLDN10(3), CLDN16(1), CLDN18(2), CLDN22(1), CLDN4(1), CLDN7(1), CNTN1(3), CNTN2(1), CNTNAP1(3), CNTNAP2(3), ESAM(1), F11R(1), GLG1(6), HLA-B(1), HLA-DMB(1), HLA-DPA1(1), HLA-DRA(1), HLA-E(2), HLA-F(1), ICAM2(1), ITGA4(2), ITGA6(2), ITGA8(2), ITGA9(2), ITGAL(3), ITGAM(1), ITGB1(2), ITGB2(1), ITGB8(1), JAM2(1), L1CAM(3), MADCAM1(4), MPZL1(1), NCAM1(1), NCAM2(1), NEGR1(2), NEO1(2), NFASC(3), NLGN1(1), NRCAM(2), NRXN1(9), NRXN2(2), NRXN3(2), PTPRC(6), PTPRF(2), PTPRM(4), PVRL2(1), PVRL3(2), SELE(2), SELP(2), SELPLG(1), SIGLEC1(2), VCAM1(2), VCAN(3) 65167216 144 110 142 63 12 9 43 64 16 0 0.96 1.00 1.00 400 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(1), ADCY2(1), ADCY3(1), ADCY5(3), ADCY6(2), ADCY8(5), ADCY9(3), ADSL(1), AK2(1), AK3L1(1), ALLC(3), AMPD1(1), AMPD2(1), ATIC(1), ENPP3(2), ENTPD2(1), ENTPD4(1), ENTPD6(1), GDA(2), GMPR(2), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2F(4), HPRT1(1), IMPDH1(2), IMPDH2(1), NME7(1), NPR1(1), NPR2(1), NT5C1B(1), NT5C3(1), NT5M(1), PAICS(2), PAPSS1(2), PAPSS2(1), PDE10A(1), PDE11A(3), PDE1C(2), PDE2A(3), PDE3B(3), PDE4A(3), PDE4B(1), PDE4C(3), PDE4D(1), PDE5A(2), PDE8A(3), PFAS(1), POLA1(2), POLD1(3), POLD2(1), POLD3(1), POLE(4), POLR1A(1), POLR1B(2), POLR2A(5), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(2), POLR3B(4), POLR3G(2), POLR3H(1), PRIM1(1), PRIM2(5), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RRM1(1), RRM2(1), XDH(1) 72252209 133 105 129 45 16 6 47 40 22 2 0.52 1.00 1.00 401 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(2), ACTN2(2), ACTN3(1), ACTN4(2), ARHGAP5(3), BCAR1(2), CD99(1), CDC42(2), CDH5(2), CLDN10(3), CLDN16(1), CLDN18(2), CLDN22(1), CLDN4(1), CLDN7(1), CTNNA1(4), CTNNA2(3), CTNNA3(3), CTNNB1(2), CTNND1(4), CXCR4(1), ESAM(1), F11R(1), GNAI1(2), GNAI2(1), GRLF1(3), ITGA4(2), ITGAL(3), ITGAM(1), ITGB1(2), ITGB2(1), JAM2(1), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(7), MMP2(1), MSN(4), MYL2(1), MYL7(1), MYL9(1), NCF1(1), NCF2(1), NOX1(2), NOX3(2), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PLCG2(2), PRKCG(1), PTK2(1), PTK2B(2), PTPN11(1), PXN(2), RAP1B(2), RAPGEF3(1), RAPGEF4(1), RASSF5(1), RHOH(1), ROCK1(3), ROCK2(3), TXK(1), VAV1(2), VAV2(3), VAV3(2), VCAM1(2), VCL(1) 54872804 143 104 142 54 11 10 43 52 27 0 0.73 1.00 1.00 402 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTG1(4), ACTN1(2), ACTN2(2), ACTN3(1), ACTN4(2), ACVR1B(3), ACVR1C(2), CDC42(2), CDH1(3), CREBBP(4), CTNNA1(4), CTNNA2(3), CTNNA3(3), CTNNB1(2), CTNND1(4), EGFR(4), EP300(6), ERBB2(3), FER(1), FGFR1(4), FYN(1), IGF1R(1), INSR(2), IQGAP1(2), LEF1(1), LMO7(4), MAP3K7(2), MAPK1(1), MAPK3(1), MET(5), MLLT4(7), PARD3(3), PTPN1(1), PTPN6(1), PTPRB(3), PTPRF(2), PTPRJ(4), PTPRM(4), PVRL2(1), PVRL3(2), RAC3(1), SMAD2(3), SMAD4(3), SNAI1(1), SNAI2(1), SORBS1(1), SRC(1), TCF7(2), TCF7L2(1), TGFBR2(1), TJP1(4), VCL(1), WASF1(2), WASF2(1), WASF3(1), WASL(5), YES1(1) 52730305 137 102 136 51 8 14 42 60 13 0 0.79 1.00 1.00 403 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(1), ADCY2(1), ADCY3(1), ADCY5(3), ADCY6(2), ADCY8(5), ADCY9(3), DRD1(1), DRD2(1), EGF(3), EGFR(4), GJD2(2), GNA11(1), GNAI1(2), GNAI2(1), GNAS(3), GRM1(4), GRM5(3), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2F(4), HTR2A(2), HTR2C(1), ITPR1(2), ITPR2(7), ITPR3(1), KRAS(4), MAP2K1(1), MAP3K2(2), MAPK1(1), MAPK3(1), MAPK7(1), NPR1(1), NPR2(1), NRAS(1), PDGFA(1), PDGFD(1), PDGFRA(6), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PRKACA(1), PRKACB(1), PRKACG(2), PRKCG(1), PRKG1(2), PRKG2(3), PRKX(1), SOS1(4), SOS2(1), SRC(1), TJP1(4), TUBA1A(1), TUBA3C(1), TUBA3D(2), TUBA4A(2), TUBAL3(1), TUBB(1), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), TUBB6(1) 58275598 129 102 129 52 17 7 35 56 14 0 0.91 1.00 1.00 404 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(2), CALM2(1), CDS2(1), DGKB(1), DGKG(2), DGKH(4), DGKI(1), DGKQ(1), DGKZ(2), IMPA2(1), INPP4A(1), INPP4B(3), INPP5A(1), INPP5B(3), INPP5D(1), INPPL1(1), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(1), OCRL(2), PI4KA(9), PI4KB(2), PIK3C2A(2), PIK3C2G(1), PIK3C3(4), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PIP4K2A(1), PIP4K2C(1), PIP5K1C(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCD4(2), PLCE1(3), PLCG2(2), PRKCG(1), PTEN(16), SYNJ1(4), SYNJ2(3) 55281202 126 101 125 52 15 7 38 41 25 0 0.86 1.00 1.00 405 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), AKT3(2), BCAR1(2), CAPN1(1), CAPN10(1), CAPN11(1), CAPN2(1), CAPN3(3), CAPN6(1), CAPN7(1), CAPN9(2), CDC42(2), CSK(2), DOCK1(5), FYN(1), GIT2(1), ITGA10(2), ITGA11(3), ITGA2(3), ITGA2B(1), ITGA3(2), ITGA4(2), ITGA6(2), ITGA7(1), ITGA8(2), ITGA9(2), ITGAD(2), ITGAE(3), ITGAL(3), ITGAM(1), ITGAX(2), ITGB1(2), ITGB2(1), ITGB5(2), ITGB6(3), ITGB8(1), MAP2K1(1), MAP2K3(2), MAPK10(2), MAPK12(1), MAPK4(1), MAPK6(3), MAPK7(1), MYLK2(2), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PIK3R2(1), PTK2(1), PXN(2), RAC3(1), RAP1B(2), RAPGEF1(1), ROCK1(3), ROCK2(3), SDCCAG8(1), SHC1(2), SORBS1(1), SOS1(4), SRC(1), TLN1(6), TNS1(2), VAV2(3), VAV3(2), VCL(1), ZYX(1) 59320539 124 99 124 42 12 10 39 51 12 0 0.45 1.00 1.00 406 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(3), ATM(15), BUB1(2), BUB1B(1), BUB3(1), CCNA1(1), CCNB2(5), CCNB3(4), CCND2(1), CCNE1(1), CCNH(1), CDAN1(3), CDC14A(4), CDC20(1), CDC25A(1), CDC25C(2), CDC6(1), CDC7(1), CDH1(3), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(3), CHEK1(1), CHEK2(7), DTX4(1), E2F4(1), E2F5(1), E2F6(1), EP300(6), ESPL1(6), GSK3B(1), HDAC1(1), HDAC4(1), HDAC6(2), MAD2L1(1), MCM2(3), MCM5(1), MCM6(1), MCM7(6), MPEG1(1), MPL(1), ORC1L(2), ORC3L(1), ORC4L(1), ORC5L(1), ORC6L(1), PCNA(2), PRKDC(5), RB1(2), SKP2(1), SMAD4(3), TBC1D8(4), TP53(13) 48873530 136 98 133 60 10 13 46 47 20 0 0.91 1.00 1.00 407 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(3), ABL2(1), AKT1(1), AKT2(2), AKT3(2), BRAF(5), BTC(1), CAMK2D(1), CAMK2G(2), CBL(2), CBLB(3), CBLC(1), CDKN1A(1), EGF(3), EGFR(4), ELK1(1), ERBB2(3), ERBB3(5), ERBB4(7), GAB1(1), GSK3B(1), HBEGF(1), JUN(1), KRAS(4), MAP2K1(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(1), MAPK9(1), NRAS(1), NRG1(2), NRG2(2), NRG3(2), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PLCG2(2), PRKCG(1), PTK2(1), RPS6KB1(2), RPS6KB2(1), SHC1(2), SHC2(1), SOS1(4), SOS2(1), SRC(1), STAT5A(2) 45403862 123 96 122 41 9 14 47 40 13 0 0.35 1.00 1.00 408 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BID(1), BRAF(5), FAS(3), FCGR3A(1), FCGR3B(1), FYN(1), HLA-B(1), HLA-E(2), ICAM2(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR1(1), IFNAR2(1), IFNGR1(1), ITGAL(3), ITGB2(1), KIR3DL1(2), KLRC1(2), KLRC2(2), KLRC3(1), KLRD1(1), KRAS(4), LCP2(1), MAP2K1(1), MAPK1(1), MAPK3(1), MICA(1), MICB(1), NCR2(1), NFAT5(3), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), NRAS(1), PAK1(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PLCG2(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKCG(1), PTK2B(2), PTPN11(1), PTPN6(1), RAC3(1), SH3BP2(1), SHC1(2), SHC2(1), SOS1(4), SOS2(1), SYK(1), TNFRSF10A(1), ULBP2(1), VAV1(2), VAV2(3), VAV3(2), ZAP70(2) 50207021 121 95 119 48 10 8 39 48 16 0 0.81 1.00 1.00 409 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(1), ADCY2(1), ADCY3(1), ADCY5(3), ADCY6(2), ADCY8(5), ADCY9(3), CACNA1C(8), CACNA1D(6), CACNA1F(4), CACNA1S(8), CALM1(2), CALM2(1), CAMK2D(1), CAMK2G(2), CDC42(2), EGFR(4), ELK1(1), GNA11(1), GNAS(3), GNRH2(1), HBEGF(1), ITPR1(2), ITPR2(7), ITPR3(1), JUN(1), KRAS(4), MAP2K1(1), MAP2K3(2), MAP2K7(1), MAP3K1(3), MAP3K2(2), MAP3K4(5), MAPK1(1), MAPK10(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(1), MAPK9(1), MMP14(1), MMP2(1), NRAS(1), PLA2G12A(1), PLA2G6(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLD1(3), PRKACA(1), PRKACB(1), PRKACG(2), PRKCD(1), PRKX(1), PTK2B(2), SOS1(4), SOS2(1), SRC(1) 56341636 128 95 128 48 20 8 34 51 15 0 0.76 1.00 1.00 410 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA2A(3), ADORA3(1), ADRA1A(1), ADRB2(1), AGTR1(1), AGTR2(1), AVPR1A(2), AVPR2(1), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(1), CCKBR(1), CCR4(1), CCR6(1), CHML(2), CHRM2(3), CHRM3(2), CHRM5(1), CMKLR1(1), CNR1(1), CNR2(1), CX3CR1(1), CXCR4(1), DRD1(1), DRD2(1), DRD3(1), DRD5(3), EDNRB(1), F2RL2(1), FPR1(2), GALR1(1), GALT(2), GPR17(1), GPR174(2), GPR35(1), GPR37(3), GPR37L1(1), GPR4(1), GPR50(1), GPR63(1), GPR77(1), GPR83(2), GPR85(2), HCRTR2(1), HTR1A(2), HTR1E(3), HTR2A(2), HTR2C(1), HTR5A(1), HTR7(1), LHCGR(1), LTB4R(1), MAS1(1), MC3R(1), MC4R(1), MTNR1B(1), NMUR2(2), NPY2R(1), NTSR1(1), OPRD1(3), OPRL1(2), OPRM1(3), OR12D3(2), OR1C1(1), OR1F1(1), OR1Q1(1), OR5V1(2), OR7A5(1), OR8B8(1), P2RY10(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(1), P2RY6(1), PTGER2(1), PTGFR(1), PTGIR(1), RGR(1), SSTR1(1), SSTR3(1), SSTR4(1), TBXA2R(1), TRHR(2) 53334330 115 93 115 41 25 14 24 46 6 0 0.49 1.00 1.00 411 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(1), ADCY2(1), ADCY3(1), ADCY5(3), ADCY6(2), ADCY8(5), ADSL(1), AK2(1), ALLC(3), AMPD1(1), AMPD2(1), ATIC(1), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), ENPP3(2), ENTPD2(1), GDA(2), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2F(4), HPRT1(1), IMPDH1(2), IMPDH2(1), NPR1(1), NPR2(1), NT5M(1), PAICS(2), PAPSS1(2), PAPSS2(1), PDE4A(3), PDE4B(1), PDE4C(3), PDE4D(1), PDE5A(2), PDE6B(1), PDE6C(2), PDE8A(3), PFAS(1), POLB(2), POLD1(3), POLD2(1), POLE(4), POLG(2), POLL(1), POLQ(6), POLR1B(2), POLR2A(5), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RRM1(1), RRM2(1) 56611806 111 93 110 32 16 4 32 42 17 0 0.28 1.00 1.00 412 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(5), ABCA10(2), ABCA12(7), ABCA13(13), ABCA2(2), ABCA3(1), ABCA4(9), ABCA5(3), ABCA6(2), ABCA7(7), ABCA8(3), ABCA9(2), ABCB1(9), ABCB11(2), ABCB4(1), ABCB5(3), ABCB6(1), ABCB8(1), ABCC1(3), ABCC10(3), ABCC11(3), ABCC12(2), ABCC2(2), ABCC3(1), ABCC4(3), ABCC5(1), ABCC6(3), ABCC8(1), ABCC9(4), ABCD2(1), ABCD3(2), ABCD4(4), ABCG1(2), ABCG2(1), ABCG4(2), ABCG5(1), ABCG8(3), CFTR(4), TAP1(1), TAP2(1) 52374263 121 92 121 39 8 3 39 60 11 0 0.47 1.00 1.00 413 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(1), ADCY2(1), ADCY3(1), ADCY5(3), ADCY6(2), ADCY8(5), ADCY9(3), AKAP1(1), AKAP10(1), AKAP11(3), AKAP12(1), AKAP3(1), AKAP4(2), AKAP6(4), AKAP7(1), AKAP9(10), ARHGEF1(1), CALM1(2), CALM2(1), GNA11(1), GNA13(2), GNA14(1), GNAI2(1), GNAO1(1), GNB1(2), GNB5(1), GNG3(1), IL18BP(1), ITPR1(2), KCNJ3(3), KRAS(4), NRAS(1), PDE1B(2), PDE1C(2), PDE4A(3), PDE4B(1), PDE4C(3), PDE4D(1), PDE8A(3), PLCB3(1), PPP3CC(2), PRKACA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), PRKCD(1), PRKCE(4), PRKCG(1), PRKCH(3), PRKCI(3), PRKCQ(1), PRKD1(4), PRKD3(1), SLC9A1(2), USP5(1) 51552636 111 91 109 40 13 0 34 50 14 0 0.71 1.00 1.00 414 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(3), AMY2A(1), AMY2B(3), ASCC3(4), ATP13A2(1), DDX18(3), DDX23(1), DDX4(3), DDX47(1), DDX50(4), DDX52(1), DDX54(1), DHX58(1), ENPP3(2), EP400(3), ERCC2(1), ERCC3(1), G6PC(1), GAA(2), GANC(1), GBA(1), GBA3(2), GPI(1), GUSB(2), GYS1(2), GYS2(1), IFIH1(2), MOV10L1(4), PYGB(1), PYGL(1), PYGM(2), RAD54L(3), RUVBL2(2), SETX(5), SI(8), SKIV2L2(1), SMARCA2(3), SMARCA5(2), TREH(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2A1(3), UGT2A3(4), UGT2B10(7), UGT2B11(2), UGT2B15(1), UGT2B7(2), UXS1(1) 54771122 114 90 112 53 8 8 31 49 18 0 0.97 1.00 1.00 415 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(1), AKT2(2), AKT3(2), BCL10(1), CARD11(3), CBL(2), CBLB(3), CBLC(1), CD28(2), CD3E(1), CD3G(1), CD4(1), CD8B(1), CDC42(2), CDK4(1), FYN(1), GRAP2(1), IKBKB(1), JUN(1), KRAS(4), LCP2(1), MALT1(2), MAP3K14(1), NFAT5(3), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), NRAS(1), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PDK1(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKCQ(1), PTPN6(1), PTPRC(6), SOS1(4), SOS2(1), TEC(3), VAV1(2), VAV2(3), VAV3(2), ZAP70(2) 44796397 112 90 111 30 9 10 33 51 9 0 0.18 1.00 1.00 416 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(3), AKT1(1), BMPR2(4), BUB1(2), CDKL1(1), CDS2(1), CLK1(3), CLK2(1), CLK4(2), DGKB(1), DGKG(2), DGKH(4), DGKQ(1), DGKZ(2), INPP4A(1), INPP4B(3), INPP5A(1), INPPL1(1), ITPKA(1), ITPKB(2), MAP3K10(2), NEK1(2), NEK3(2), OCRL(2), PAK4(2), PIK3C2A(2), PIK3C2G(1), PIK3CA(14), PIK3CB(2), PIK3CG(5), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCG2(2), PLK3(1), PRKACA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), PRKCD(1), PRKCE(4), PRKCG(1), PRKCH(3), PRKCQ(1), PRKD1(4), PRKG1(2), RPS6KA1(2), RPS6KA2(1), RPS6KB1(2) 50086846 109 90 106 41 13 4 37 36 19 0 0.66 1.00 1.00 417 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(1), ADCY8(5), BRAF(5), CACNA1C(8), CALM1(2), CALM2(1), CAMK2D(1), CAMK2G(2), CREBBP(4), EP300(6), GRIA1(4), GRIA2(1), GRIN1(2), GRIN2A(3), GRIN2B(10), GRM1(4), GRM5(3), ITPR1(2), ITPR2(7), ITPR3(1), KRAS(4), MAP2K1(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PPP1CB(1), PPP1R12A(4), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKACA(1), PRKACB(1), PRKACG(2), PRKCG(1), PRKX(1), RAP1B(2), RAPGEF3(1), RPS6KA1(2), RPS6KA2(1), RPS6KA6(3) 44232745 110 89 110 37 14 9 35 42 10 0 0.39 1.00 1.00 418 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(5), CACNA1A(1), GNA11(1), GNA13(2), GNAI1(2), GNAI2(1), GNAO1(1), GNAS(3), GRIA1(4), GRIA2(1), GRIA3(1), GRID2(5), GRM1(4), GRM5(3), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2F(4), IGF1(1), IGF1R(1), ITPR1(2), ITPR2(7), ITPR3(1), KRAS(4), LYN(1), MAP2K1(1), MAPK1(1), MAPK3(1), NOS1(7), NOS3(1), NPR1(1), NPR2(1), NRAS(1), PLA2G12A(1), PLA2G6(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PPP2CA(1), PPP2CB(1), PPP2R1B(1), PPP2R2A(1), PPP2R2B(3), PRKCG(1), PRKG1(2), PRKG2(3), RYR1(12) 48673514 108 85 108 59 15 8 26 47 12 0 1.00 1.00 1.00 419 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(2), CLK2(1), CLK3(1), CLK4(2), COL2A1(5), CPSF1(2), CPSF3(2), CPSF4(2), CSTF2T(2), CSTF3(2), DDX1(1), DDX20(4), DHX15(5), DHX8(1), DHX9(3), DICER1(1), DNAJC8(1), LOC440563(1), LSM7(1), METTL3(4), NONO(3), NXF1(2), PABPN1(1), PAPOLA(3), POLR2A(5), PRPF3(1), PRPF4B(1), PRPF8(7), PTBP2(1), RBM17(2), RNMT(1), SF3A1(1), SF3A3(2), SF3B1(4), SF3B2(2), SF4(2), SFRS12(3), SFRS14(1), SFRS16(1), SFRS2(1), SFRS4(2), SFRS5(1), SFRS7(1), SNRPB(1), SNRPF(1), SNRPN(2), SPOP(1), SRPK2(1), SRRM1(1), SUPT5H(4), XRN2(5) 46614015 107 85 107 26 8 7 34 47 11 0 0.097 1.00 1.00 420 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1B(3), ACVR1C(2), ACVR2A(3), ACVR2B(1), AMHR2(2), BMP5(2), BMP6(1), BMP7(1), BMPR1B(1), BMPR2(4), CHRD(2), CREBBP(4), CUL1(3), DCN(2), E2F4(1), E2F5(1), EP300(6), GDF5(1), GDF6(1), INHBA(1), LTBP1(5), MAPK1(1), MAPK3(1), PITX2(2), PPP2CA(1), PPP2CB(1), PPP2R1B(1), PPP2R2A(1), PPP2R2B(3), RBL2(3), ROCK1(3), ROCK2(3), RPS6KB1(2), RPS6KB2(1), SMAD2(3), SMAD4(3), SMAD9(2), SMURF1(1), SMURF2(2), SP1(1), TGFB2(1), TGFBR2(1), THBS1(5), THBS2(2), THBS3(3), THBS4(1), ZFYVE16(5), ZFYVE9(2) 43640391 102 84 102 33 8 7 29 43 15 0 0.47 1.00 1.00 421 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(5), BDKRB1(1), BDKRB2(1), C1R(1), C1S(2), C3(5), C3AR1(1), C4BPA(2), C5(2), C6(4), C7(2), C8B(1), CD55(2), CFH(4), CFI(2), CR1(11), CR2(1), F11(1), F12(1), F13A1(1), F13B(2), F2(2), F5(5), F8(4), FGA(2), FGB(1), FGG(2), KLKB1(1), KNG1(2), MASP1(1), MBL2(1), PLAT(1), PLAU(4), PLAUR(1), PLG(1), PROC(2), PROS1(5), SERPINA1(2), SERPIND1(1), SERPINF2(2), SERPING1(2), TFPI(1), VWF(6) 40009129 101 81 98 32 14 4 26 42 15 0 0.41 1.00 1.00 422 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 IMPA2(1), INPP4A(1), INPP4B(3), INPP5A(1), INPP5B(3), INPPL1(1), ITPKA(1), ITPKB(2), MIOX(2), OCRL(2), PI4KA(9), PI4KB(2), PIK3C3(4), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIP4K2A(1), PIP4K2C(1), PIP5K1C(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCD4(2), PLCE1(3), PLCG2(2), PTEN(16), SYNJ1(4), SYNJ2(3) 32801227 94 80 93 30 7 6 29 30 22 0 0.48 1.00 1.00 423 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(1), ADCY2(1), ADCY3(1), ADCY5(3), ADCY6(2), ADCY8(5), ADCY9(3), CALM1(2), CALM2(1), CAMK2D(1), CAMK2G(2), CREB3L3(1), CREB3L4(1), CREBBP(4), CTNNB1(2), DCT(2), DVL1(1), EDNRB(1), EP300(6), FZD1(2), FZD10(2), FZD2(1), FZD3(1), FZD4(1), FZD5(1), FZD6(1), GNAI1(2), GNAI2(1), GNAO1(1), GNAS(3), GSK3B(1), KITLG(2), KRAS(4), LEF1(1), MAP2K1(1), MAPK1(1), MAPK3(1), MITF(2), NRAS(1), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PRKACA(1), PRKACB(1), PRKACG(2), PRKCG(1), PRKX(1), TCF7(2), TCF7L2(1), TYR(1), TYRP1(1), WNT16(1), WNT2(2), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1), WNT9A(1) 47941559 95 80 94 41 8 5 31 42 9 0 0.89 1.00 1.00 424 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(1), ALG10(1), ALG10B(2), ALG13(3), ALG2(1), ALG8(2), B3GNT1(1), B3GNT2(2), B3GNT6(1), B3GNT7(1), B4GALT5(1), C1GALT1(1), C1GALT1C1(1), CHST1(1), CHST11(1), CHST4(2), CHST7(1), DDOST(1), DPAGT1(2), EXT1(1), EXTL1(1), EXTL2(1), EXTL3(2), FUT11(1), GALNT1(1), GALNT10(2), GALNT11(2), GALNT13(3), GALNT4(1), GALNT5(5), GALNT7(3), GALNT8(3), GALNT9(1), GALNTL2(1), GALNTL5(2), GANAB(1), GCNT1(2), GCNT4(1), HS2ST1(1), HS3ST2(1), HS3ST3A1(1), HS3ST5(1), HS6ST3(1), MAN2A1(2), MGAT3(1), MGAT4A(3), MGAT5(3), MGAT5B(1), NDST1(1), NDST2(2), NDST3(1), NDST4(3), OGT(3), RPN1(1), RPN2(2), ST3GAL1(1), ST3GAL3(1), ST6GALNAC1(1), STT3B(2), WBSCR17(4), XYLT1(1), XYLT2(2) 48572499 100 79 100 38 9 4 31 45 11 0 0.79 1.00 1.00 425 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(1), BRAF(5), DAXX(4), ELK1(1), IKBKB(1), JUN(1), MAP2K1(1), MAP2K3(2), MAP2K7(1), MAP3K1(3), MAP3K10(2), MAP3K11(1), MAP3K12(1), MAP3K13(1), MAP3K14(1), MAP3K2(2), MAP3K4(5), MAP3K5(4), MAP3K6(2), MAP3K7(2), MAP3K9(1), MAP4K3(2), MAP4K4(2), MAPK1(1), MAPK10(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(1), MAPK6(3), MAPK7(1), MAPK8(1), MAPK9(1), MAX(3), MEF2A(2), MEF2C(2), MEF2D(1), MKNK1(1), MKNK2(2), PAK1(1), PAK2(2), RELA(1), RIPK1(2), RPS6KA1(2), RPS6KA2(1), RPS6KB1(2), RPS6KB2(1), SHC1(2), SP1(1), STAT1(2), TGFB2(1), TRADD(1) 42255034 90 76 90 29 10 10 25 28 17 0 0.42 1.00 1.00 426 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(1), ATM(15), ATR(5), BAI1(1), BID(1), CCNB2(5), CCNB3(4), CCND2(1), CCNE1(1), CCNG2(2), CD82(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(3), CHEK1(1), CHEK2(7), FAS(3), GTSE1(1), IGF1(1), LRDD(1), PTEN(16), RFWD2(2), RRM2(1), SERPINB5(3), STEAP3(1), THBS1(5), TP53(13), TP53I3(2), TP73(1), TSC2(2) 28841803 103 75 100 34 9 4 40 30 20 0 0.39 1.00 1.00 427 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 CABIN1(4), CALM1(2), CALM2(1), CD3E(1), CD3G(1), CDKN1A(1), CNR1(1), CREBBP(4), EP300(6), FCGR3A(1), GATA4(1), GRLF1(3), GSK3A(1), GSK3B(1), IFNA1(1), IL2RA(2), IL3(1), KPNA5(2), MAP2K7(1), MAPK14(1), MAPK8(1), MAPK9(1), MEF2A(2), MEF2D(1), NFAT5(3), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), NPPB(1), NUP214(2), OPRD1(3), PAK1(1), PPP3CB(1), PPP3CC(2), PPP3R1(1), PTPRC(6), RELA(1), SP1(1), SP3(1), TRPV6(1), VAV1(2), VAV2(3), VAV3(2), XPO5(2) 40090251 82 74 82 28 9 4 29 32 8 0 0.48 1.00 1.00 428 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(1), AKT2(2), AKT3(2), CDC42(2), KDR(5), KRAS(4), MAP2K1(1), MAPK1(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), NFAT5(3), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), NOS3(1), NRAS(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PLA2G12A(1), PLA2G6(1), PLCG2(2), PPP3CB(1), PPP3CC(2), PPP3R1(1), PRKCG(1), PTGS2(4), PTK2(1), PXN(2), RAC3(1), SHC2(1), SPHK2(1), SRC(1) 31806814 81 67 80 30 6 6 25 33 11 0 0.70 1.00 1.00 429 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(1), AKT2(2), AKT3(2), FYN(1), GAB2(1), IL3(1), INPP5D(1), KRAS(4), LCP2(1), LYN(1), MAP2K1(1), MAP2K3(2), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(1), MAPK9(1), NRAS(1), PDK1(1), PIK3CA(14), PIK3CB(2), PIK3CD(1), PIK3CG(5), PIK3R1(1), PIK3R2(1), PIK3R5(2), PLA2G12A(1), PLA2G6(1), PLCG2(2), PRKCD(1), PRKCE(4), RAC3(1), SOS1(4), SOS2(1), SYK(1), VAV1(2), VAV2(3), VAV3(2) 31864345 79 67 77 27 8 8 24 27 12 0 0.45 1.00 1.00 430 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(15), CCNA1(1), CCND2(1), CCNE1(1), CCNG2(2), CCNH(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(3), CDKN2C(1), CREB3L3(1), CREB3L4(1), E2F4(1), E2F5(1), E2F6(1), GBA2(2), MCM2(3), MCM5(1), MCM6(1), MCM7(6), NACA(1), ORC1L(2), ORC3L(1), ORC4L(1), ORC5L(1), ORC6L(1), PCNA(2), POLE(4), PRIM1(1), RB1(2), RPA2(1), RPA3(1), TFDP2(3), TNXB(2), TP53(13) 34092726 83 63 83 42 7 3 27 30 16 0 0.98 1.00 1.00 431 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 DOCK1(5), ELK1(1), GAB1(1), HGF(1), ITGA1(4), ITGB1(2), JUN(1), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(1), MET(5), PAK1(1), PIK3CA(14), PIK3R1(1), PTEN(16), PTK2(1), PTK2B(2), PTPN11(1), PXN(2), RAP1B(2), RASA1(2), SOS1(4), SRC(1), STAT3(1) 19548558 72 61 71 23 2 6 32 23 9 0 0.37 1.00 1.00 432 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(1), CAD(2), DCTD(1), DPYD(1), DPYS(1), DUT(1), ENTPD4(1), ENTPD6(1), NME7(1), NT5C1B(1), NT5C3(1), NT5M(1), POLA1(2), POLD1(3), POLD2(1), POLD3(1), POLE(4), POLR1A(1), POLR1B(2), POLR2A(5), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(2), POLR3B(4), POLR3G(2), POLR3H(1), PRIM1(1), PRIM2(5), RRM1(1), RRM2(1), TK1(1), TXNRD1(3), TXNRD2(1), UCK1(1), UMPS(1), UPB1(1), UPP2(2), UPRT(2) 35881620 67 60 64 27 5 7 25 18 10 2 0.74 1.00 1.00 433 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(1), CAD(2), CASP10(2), CASP8AP2(4), CD7(1), CSNK1A1(1), DAXX(4), DEDD(1), EGFR(4), EPHB2(1), FAF1(1), MAP2K7(1), MAP3K1(3), MAP3K5(4), MAPK1(1), MAPK10(2), MAPK8(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), MET(5), NFAT5(3), NFKBIL2(2), PTPN13(7), RALBP1(1), RIPK1(2), ROCK1(3), SMPD1(1), TP53(13), TPX2(2) 32450659 78 60 78 31 6 6 20 33 13 0 0.82 1.00 1.00 434 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(5), CPEB1(4), EGFR(4), ERBB2(3), ERBB4(7), ETS1(1), ETV6(1), FMN2(8), KRAS(4), MAP2K1(1), MAPK1(1), MAPK3(1), NOTCH1(4), NOTCH2(5), NOTCH3(3), PIWIL1(2), PIWIL2(2), PIWIL3(1), PIWIL4(1), SOS1(4), SOS2(1), SPIRE1(1), SPIRE2(2) 22998674 66 59 65 24 6 5 20 25 10 0 0.78 1.00 1.00 435 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(4), ACSL1(2), ACSL3(1), ACSL4(1), ACSL5(2), ACSL6(4), AKT1(1), AKT2(2), AKT3(2), CAMKK1(1), CAMKK2(1), CPT1A(1), G6PC(1), IKBKB(1), IRS1(3), IRS2(1), JAK1(4), JAK2(5), JAK3(2), LEPR(1), MAPK10(2), MAPK8(1), MAPK9(1), PCK1(2), PCK2(2), PPARGC1A(1), PRKAA1(1), PRKAG1(1), PRKAG2(1), PRKCQ(1), PTPN11(1), RELA(1), RXRB(3), RXRG(1), STAT3(1), TNFRSF1A(2), TRADD(1), TYK2(3) 36548449 66 59 66 24 5 8 19 26 8 0 0.67 1.00 1.00 436 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 CREBBP(4), DUT(1), EHHADH(2), EP300(6), FABP1(1), HSD17B4(1), JUN(1), LPL(1), MAPK1(1), MAPK3(1), ME1(1), NCOA1(2), NCOR1(6), NCOR2(3), NR1H3(1), NRIP1(3), PDGFA(1), PIK3CA(14), PIK3R1(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), PTGS2(4), RB1(2), RELA(1), SP1(1), SRA1(1), STAT5A(2) 27854453 68 59 67 27 3 7 28 24 6 0 0.62 1.00 1.00 437 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(15), ATR(5), BRCA1(3), BRCA2(9), CHEK1(1), CHEK2(7), FANCA(4), FANCD2(2), FANCE(3), FANCF(2), FANCG(3), HUS1(1), RAD17(2), RAD50(2), RAD51(2), TP53(13), TREX1(1) 19433571 75 56 72 30 6 3 29 25 12 0 0.80 1.00 1.00 438 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADM(1), ACOX2(1), ACOX3(3), ACSL1(2), ACSL3(1), ACSL4(1), ACSL5(2), ACSL6(4), ANGPTL4(1), APOA5(1), AQP7(1), CPT1A(1), CYP27A1(1), CYP4A11(4), CYP8B1(3), DBI(1), EHHADH(2), FABP1(1), FABP6(1), FADS2(2), GK(1), HMGCS2(1), LPL(1), ME1(1), NR1H3(1), PCK1(2), PCK2(2), PLTP(2), PPARG(1), RXRB(3), RXRG(1), SCP2(2), SLC27A1(2), SLC27A4(1), SLC27A5(2), SLC27A6(3), SORBS1(1), UBC(3), UCP1(1) 28824062 65 56 65 23 7 9 21 23 5 0 0.54 1.00 1.00 439 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(6), B3GALT4(1), DGKI(1), FAU(1), IL6ST(3), PIGK(1), RPL11(1), RPL15(1), RPL18(2), RPL18A(1), RPL19(1), RPL22(1), RPL27(1), RPL28(2), RPL3(1), RPL30(2), RPL31(1), RPL34(1), RPL3L(1), RPL4(1), RPL5(2), RPL7(1), RPL9(1), RPLP0(1), RPS11(1), RPS13(1), RPS2(1), RPS21(1), RPS24(1), RPS26(2), RPS27(1), RPS29(1), RPS3(1), RPS3A(1), RPS4Y1(1), RPS6KA1(2), RPS6KA2(1), RPS6KA6(3), RPS6KB1(2), RPS6KB2(1), TBC1D10C(1), TSPAN9(1), UBC(3) 23288024 61 55 61 17 6 3 19 24 9 0 0.30 1.00 1.00 440 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP5(2), BMP6(1), BMP7(1), CSNK1A1(1), CSNK1E(2), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GAS1(1), GLI1(1), GLI2(3), GLI3(4), GSK3B(1), HHIP(1), LRP2(8), PRKACA(1), PRKACB(1), PRKACG(2), PRKX(1), PTCH1(5), SHH(1), SMO(3), STK36(3), WNT16(1), WNT2(2), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1), WNT9A(1) 26812741 55 54 55 22 9 4 15 23 4 0 0.81 1.00 1.00 441 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(1), AASS(5), AKR1B10(3), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), BBOX1(1), DLST(2), DOT1L(3), ECHS1(1), EHHADH(2), EHMT1(1), EHMT2(2), GCDH(1), HADH(1), HADHA(1), HSD17B4(1), NSD1(5), OGDH(1), OGDHL(2), PLOD2(3), PLOD3(2), RDH11(2), SETD1A(1), SETDB1(3), SHMT1(2), SHMT2(2), SPCS1(2), SUV39H2(3), TMLHE(1) 25609341 61 53 61 21 8 8 17 17 11 0 0.50 1.00 1.00 442 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(4), ATP6V0A1(3), ATP6V0A4(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C1(2), CDC42(2), CSK(2), EGFR(4), F11R(1), HBEGF(1), IKBKB(1), JAM2(1), JUN(1), LYN(1), MAP3K14(1), MAPK10(2), MAPK12(1), MAPK13(1), MAPK14(1), MAPK8(1), MAPK9(1), MET(5), NOD1(2), PAK1(1), PLCG2(2), PTPN11(1), PTPRZ1(9), RELA(1), SRC(1), TJP1(4) 30870945 65 53 65 20 2 4 26 30 3 0 0.41 1.00 1.00 443 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(15), ATR(5), BRCA1(3), CDC25A(1), CDC25C(2), CDKN1A(1), CHEK1(1), CHEK2(7), EP300(6), PRKDC(5), RPS6KA1(2), TP53(13) 18713605 61 51 58 26 5 4 22 19 11 0 0.82 1.00 1.00 444 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(3), CALR(1), CANX(3), CD4(1), CD74(1), CD8B(1), CIITA(1), CTSB(4), CTSL1(1), CTSS(1), HLA-B(1), HLA-DMB(1), HLA-DPA1(1), HLA-DRA(1), HLA-E(2), HLA-F(1), HSP90AA1(5), HSP90AB1(2), HSPA5(2), IFI30(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA7(1), IFNA8(1), KIR3DL1(2), KIR3DL3(1), KLRC1(2), KLRC2(2), KLRC3(1), KLRD1(1), LGMN(1), LTA(1), RFX5(1), TAP1(1), TAP2(1) 20607714 55 51 54 22 4 2 16 28 5 0 0.89 1.00 1.00 445 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(2), CALM2(1), CD3E(1), CD3G(1), ELK1(1), FYN(1), JUN(1), MAP2K1(1), MAP3K1(3), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), PIK3CA(14), PIK3R1(1), PPP3CB(1), PPP3CC(2), PTPN7(1), RASA1(2), RELA(1), SHC1(2), SOS1(4), SYT1(1), VAV1(2), ZAP70(2) 21015565 55 51 54 21 7 6 18 18 6 0 0.64 1.00 1.00 446 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(6), AXIN1(1), CCND2(1), CSNK1E(2), CTNNB1(2), DVL1(1), FZD1(2), FZD10(2), FZD2(1), FZD3(1), FZD5(1), FZD6(1), GSK3B(1), JUN(1), MAPK10(2), MAPK9(1), PAFAH1B1(1), PLAU(4), PRKCD(1), PRKCE(4), PRKCG(1), PRKCH(3), PRKCI(3), PRKCQ(1), PRKD1(4), SFRP4(2), TCF7(2), WNT16(1), WNT2(2), WNT5B(1), WNT7B(1) 26367143 57 50 54 31 4 5 18 20 10 0 0.97 1.00 1.00 447 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(1), ALPP(3), ALPPL2(1), ASCC3(4), ATP13A2(1), DDX18(3), DDX23(1), DDX4(3), DDX47(1), DDX50(4), DDX52(1), DDX54(1), DHFR(1), DHX58(1), EP400(3), ERCC2(1), ERCC3(1), FPGS(1), GGH(1), IFIH1(2), MOV10L1(4), QDPR(1), RAD54L(3), RUVBL2(2), SETX(5), SKIV2L2(1), SMARCA2(3), SMARCA5(2) 27726108 58 49 58 24 3 6 16 23 10 0 0.78 1.00 1.00 448 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(1), APC(6), AR(1), BRAF(5), EGFR(4), GNA11(1), GNAI1(2), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(1), KCNJ3(3), MAPK1(1), MAPK10(2), MAPK14(1), PHKA2(1), PIK3CA(14), PIK3CD(1), PIK3R1(1), PITX2(2), SRC(1) 23571933 60 49 59 25 9 7 21 17 6 0 0.65 1.00 1.00 449 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(1), ATF2(1), CDC42(2), DLD(4), DUSP10(1), GAB1(1), JUN(1), MAP2K7(1), MAP3K1(3), MAP3K10(2), MAP3K11(1), MAP3K12(1), MAP3K13(1), MAP3K2(2), MAP3K4(5), MAP3K5(4), MAP3K7(2), MAP3K9(1), MAPK10(2), MAPK7(1), MAPK8(1), MAPK9(1), NFATC3(3), PAPPA(1), SHC1(2), TP53(13), TRAF6(1), ZAK(2) 22168761 61 49 61 21 6 5 17 21 12 0 0.58 1.00 1.00 450 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADHFE1(1), AKR1C1(1), AKR1C4(1), ALDH3B1(2), ALDH3B2(1), CYP1A1(1), CYP1A2(2), CYP2B6(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(2), CYP2F1(1), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(1), DHDH(1), EPHX1(3), GSTA3(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2A1(3), UGT2A3(4), UGT2B10(7), UGT2B11(2), UGT2B15(1), UGT2B7(2) 25263220 60 48 58 23 6 7 17 23 7 0 0.72 1.00 1.00 451 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(4), CTBP1(1), DLL3(1), DLL4(2), DTX1(1), DTX3L(1), DTX4(1), DVL1(1), EP300(6), HDAC1(1), JAG1(2), JAG2(2), MAML1(2), MAML2(2), MAML3(3), NCOR2(3), NOTCH1(4), NOTCH2(5), NOTCH3(3), NUMB(2), NUMBL(1), PSEN2(1), PSENEN(1), RBPJ(2), RBPJL(1), SNW1(1) 30652863 54 48 54 28 6 2 18 20 8 0 0.95 1.00 1.00 452 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(1), AKT2(2), AKT3(2), BRAF(5), DRD2(1), EGFR(4), EPHB2(1), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(1), KCNJ3(3), MAPK1(1), PIK3CB(2), PITX2(2), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), SHC1(2), SOS1(4), SOS2(1), SRC(1), STAT3(1) 25832269 52 48 52 21 9 4 18 17 4 0 0.72 1.00 1.00 453 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(4), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), AOC2(1), AOC3(1), AOX1(4), CAT(2), CYP19A1(3), CYP1A1(1), CYP1A2(2), CYP2A13(3), CYP2B6(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(2), CYP2F1(1), CYP2J2(1), CYP3A4(1), CYP3A5(1), CYP3A7(1), CYP4B1(1), DDC(3), ECHS1(1), EHHADH(2), GCDH(1), HADHA(1), MAOA(1), MAOB(1), TPH1(3), WARS2(2) 24277780 54 48 54 20 7 3 20 22 2 0 0.56 1.00 1.00 454 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(1), CDK2(1), CDT1(1), DIAPH2(4), MCM10(3), MCM2(3), MCM5(1), MCM6(1), MCM7(6), NACA(1), ORC1L(2), ORC3L(1), ORC4L(1), ORC5L(1), ORC6L(1), PCNA(2), POLD1(3), POLD2(1), POLD3(1), POLE(4), PRIM1(1), RFC1(2), RFC4(3), RPA2(1), RPA3(1), RPA4(1), UBC(3) 22456358 52 47 52 17 6 1 16 19 10 0 0.52 1.00 1.00 455 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 CALM1(2), CALM2(1), ELK1(1), JUN(1), LYN(1), MAP2K1(1), MAP2K7(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), PAK2(2), PIK3CA(14), PIK3R1(1), PPP3CB(1), PPP3CC(2), SHC1(2), SOS1(4), SYK(1), SYT1(1), VAV1(2) 18913806 52 47 51 20 6 6 17 16 7 0 0.64 1.00 1.00 456 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY6(2), ADCY8(5), CACNA1A(1), CACNA1B(3), GNAS(3), GNB1(2), GNG3(1), GRM4(2), ITPR3(1), KCNB1(1), PLCB2(1), PRKACA(1), PRKACB(1), PRKACG(2), PRKX(1), SCNN1A(2), SCNN1B(2), SCNN1G(1), TAS1R2(2), TAS1R3(2), TAS2R1(1), TAS2R38(1), TAS2R39(1), TAS2R40(1), TAS2R42(2), TAS2R46(1), TAS2R50(2), TAS2R60(1), TAS2R7(1), TAS2R8(1), TAS2R9(1) 25266577 49 47 49 14 11 1 11 17 9 0 0.36 1.00 1.00 457 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3L1(1), CAD(2), DCTD(1), DPYD(1), DPYS(1), DUT(1), NT5M(1), POLB(2), POLD1(3), POLD2(1), POLE(4), POLG(2), POLL(1), POLQ(6), POLR1B(2), POLR2A(5), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1), RRM1(1), RRM2(1), TK1(1), TXNRD1(3), UCK1(1), UMPS(1), UPB1(1) 25281471 50 47 50 17 5 5 15 19 6 0 0.51 1.00 1.00 458 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), ACTR3(1), AKT1(1), GCA(1), ITGA9(2), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(7), ITPR3(1), MAP2K1(1), MAPK1(1), MAPK3(1), NR1I3(1), PAK1(1), PDE3A(3), PDE3B(3), PIK3C2G(1), PIK3CA(14), PIK3CD(1), PIK3R1(1), RIPK3(1) 21603402 49 46 48 16 7 6 16 16 4 0 0.40 1.00 1.00 459 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(1), CCKBR(1), CELSR1(3), CELSR2(4), CELSR3(4), CHRM2(3), CHRM3(2), EMR3(6), GHRHR(1), GPR116(2), GPR133(1), GPR17(1), GPR56(1), GPR61(1), GPR77(1), GPR84(2), GRM1(4), HRH4(1), LGR6(1), LPHN2(2), LPHN3(4), NTSR1(1), OR2M4(1), OR8G2(2), P2RY13(1), PTGFR(1), SMO(3) 29367292 55 45 55 19 9 4 18 22 2 0 0.39 1.00 1.00 460 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(4), APAF1(1), ARHGDIB(1), BAG4(1), BID(1), BIRC2(2), BIRC3(2), CASP2(2), CASP7(1), CFLAR(1), DAXX(4), GSN(1), LMNA(1), MAP2K7(1), MAP3K1(3), MAP3K14(1), MAP3K5(4), MAPK8(1), NUMA1(1), PAK2(2), PRKCD(1), PRKDC(5), PSEN2(1), PTK2(1), RASA1(2), RB1(2), RELA(1), RIPK1(2), SPTAN1(3), TNFRSF1A(2), TRADD(1) 30804788 56 45 56 24 4 6 20 20 6 0 0.76 1.00 1.00 461 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(3), ACTG1(4), ARHGEF2(1), CDC42(2), CDH1(3), CTNNB1(2), FYN(1), HCLS1(1), ITGB1(2), NCL(2), ROCK1(3), ROCK2(3), TLR4(1), TLR5(1), TUBA1A(1), TUBA3C(1), TUBA3D(2), TUBA4A(2), TUBAL3(1), TUBB(1), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), TUBB6(1), WASL(5) 23089008 51 45 51 24 5 3 19 21 3 0 0.88 1.00 1.00 462 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(3), ACTG1(4), ARHGEF2(1), CDC42(2), CDH1(3), CTNNB1(2), FYN(1), HCLS1(1), ITGB1(2), NCL(2), ROCK1(3), ROCK2(3), TLR4(1), TLR5(1), TUBA1A(1), TUBA3C(1), TUBA3D(2), TUBA4A(2), TUBAL3(1), TUBB(1), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), TUBB6(1), WASL(5) 23089008 51 45 51 24 5 3 19 21 3 0 0.88 1.00 1.00 463 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 ELK1(1), JAK1(4), JUN(1), MAP2K1(1), MAP3K1(3), MAPK3(1), MAPK8(1), PDGFA(1), PDGFRA(6), PIK3CA(14), PIK3R1(1), RASA1(2), SHC1(2), SOS1(4), STAT1(2), STAT3(1), STAT5A(2) 15338689 47 45 46 22 3 4 17 17 6 0 0.88 1.00 1.00 464 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(3), FYN(1), GSN(1), ITGA1(4), ITGB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), MYL2(1), MYLK(3), PIK3CA(14), PIK3R1(1), PTK2(1), PXN(2), ROCK1(3), SHC1(2), SRC(1), TLN1(6) 16440988 48 44 47 16 3 6 15 19 5 0 0.54 1.00 1.00 465 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(3), EGFR(4), ELK1(1), JAK1(4), JUN(1), MAP2K1(1), MAP3K1(3), MAPK3(1), MAPK8(1), PIK3CA(14), PIK3R1(1), RASA1(2), SHC1(2), SOS1(4), STAT1(2), STAT3(1), STAT5A(2) 16469635 47 43 46 19 3 4 19 13 8 0 0.75 1.00 1.00 466 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 DAXX(4), EGF(3), EGFR(4), ETS1(1), IKBKB(1), JUN(1), MAP2K1(1), MAP2K3(2), MAP2K7(1), MAP3K1(3), MAP3K14(1), MAP3K5(4), MAPK1(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(1), PPP2CA(1), PRKCD(1), PRKCE(4), PRKCG(1), PRKCH(3), PRKCQ(1), RELA(1), RIPK1(2), SP1(1), TNFRSF1A(2) 21595785 48 43 46 20 5 3 11 17 12 0 0.81 1.00 1.00 467 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(1), CBL(2), CFLAR(1), IL2RA(2), IL2RB(1), IRS1(3), JAK1(4), JAK3(2), MAPK1(1), MAPK3(1), PIK3CA(14), PIK3R1(1), PTPN6(1), RPS6KB1(2), SHC1(2), SOS1(4), STAT5A(2), SYK(1) 15912501 45 42 44 17 5 4 17 14 5 0 0.59 1.00 1.00 468 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(1), INPP4B(3), INPP5A(1), INPPL1(1), ITPKA(1), ITPKB(2), MIOX(2), OCRL(2), PIK3C2A(2), PIK3C2G(1), PIK3CA(14), PIK3CB(2), PIK3CG(5), PLCB1(1), PLCB2(1), PLCB3(1), PLCB4(3), PLCD1(1), PLCG2(2) 19869516 46 42 45 18 4 3 14 16 9 0 0.80 1.00 1.00 469 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(1), ATF1(1), BRAF(5), CREBBP(4), EGR1(1), ELK1(1), FRS2(1), JUN(1), MAP1B(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1), NTRK1(2), PIK3C2G(1), PIK3CA(14), PIK3CD(1), PIK3R1(1), PTPN11(1), SHC1(2), SRC(1) 22813930 50 42 49 26 5 5 19 16 5 0 0.94 1.00 1.00 470 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(2), CD28(2), CSK(2), EPHB2(1), FBXW7(4), GRAP2(1), ITPKA(1), ITPKB(2), LCP2(1), MAPK1(1), NFAT5(3), NFKBIL2(2), PAK1(1), PAK2(2), PAK3(1), PAK4(2), PAK7(2), PTPRC(6), RASGRP2(2), RASGRP4(2), SOS1(4), SOS2(1), VAV1(2), ZAP70(2) 24739593 49 42 49 22 7 6 12 22 2 0 0.89 1.00 1.00 471 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(3), AMY2A(1), AMY2B(3), ENPP3(2), G6PC(1), GAA(2), GANAB(1), GBA3(2), GPI(1), GUSB(2), GYS1(2), GYS2(1), PYGB(1), PYGL(1), PYGM(2), SI(8), UCHL3(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2B15(1), UXS1(1) 25271823 48 42 48 23 3 3 13 21 8 0 0.95 1.00 1.00 472 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(1), AZIN1(1), BTG1(1), CLOCK(3), EIF4G2(2), ETV6(1), HERPUD1(1), HSPA8(6), KLF9(2), MYF6(1), NCKAP1(2), NCOA4(4), PER1(5), PER2(3), PPP2CB(1), PSMA4(2), SF3A3(2), TOB1(1), TUBB3(3), ZFR(3) 16162603 45 41 45 16 4 4 14 16 7 0 0.50 1.00 1.00 473 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACADM(1), ACADS(2), ACOX3(3), ACSL1(2), ACSL3(1), ACSL4(1), ACSL5(2), ACSL6(4), ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADHFE1(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), CPT1A(1), CYP4A11(4), ECHS1(1), EHHADH(2), GCDH(1), HADH(1), HADHA(1), HADHB(1), HSD17B4(1), PECI(3) 21555151 43 41 42 16 6 9 15 8 5 0 0.39 1.00 1.00 474 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 AGPAT6(2), CDS2(1), CHAT(2), CHKB(1), CHPT1(1), DGKB(1), DGKG(2), DGKH(4), DGKI(1), DGKQ(1), DGKZ(2), ESCO1(2), ETNK1(1), ETNK2(1), GNPAT(2), GPAM(1), LYPLA1(1), MYST3(6), MYST4(3), PCYT1B(1), PISD(1), PLA2G12A(1), PLA2G6(1), PLD1(3), PNPLA3(1), PPAP2B(1), PTDSS1(2), SH3GLB1(1) 29017920 47 41 47 24 10 4 13 19 1 0 0.90 1.00 1.00 475 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(4), AGMAT(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(1), ARG1(1), CPS1(5), DAO(1), GLUD1(2), GOT1(2), GOT2(3), MAOA(1), MAOB(1), NOS1(7), NOS3(1), OTC(1), P4HA2(1), P4HA3(1), PYCR1(1), SMS(2) 19521954 45 40 45 19 2 1 18 19 5 0 0.85 1.00 1.00 476 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(3), ATM(15), BRCA1(3), CDKN1A(1), CHEK1(1), CHEK2(7), JUN(1), MAPK8(1), RAD50(2), RAD51(2), RELA(1), TP53(13), TP73(1) 13144815 51 40 48 25 4 3 21 14 9 0 0.92 1.00 1.00 477 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(2), ACTN2(2), ACTN3(1), BCAR1(2), CAPN1(1), CSK(2), FYN(1), ITGA1(4), ITGB1(2), JUN(1), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(1), PPP1R12B(1), PTK2(1), PXN(2), ROCK1(3), SHC1(2), SOS1(4), SRC(1), TLN1(6), VCL(1), ZYX(1) 20766111 44 40 44 18 4 4 14 17 5 0 0.82 1.00 1.00 478 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(1), BID(1), BIRC2(2), BIRC3(2), CASP1(1), CASP10(2), CASP2(2), CASP4(1), CASP7(1), FAS(3), HELLS(3), IKBKB(1), IRF2(1), JUN(1), LTA(1), MAP3K1(3), MAPK10(2), RELA(1), RIPK1(2), TNFRSF1A(2), TP53(13), TP73(1), TRADD(1) 25350655 48 39 48 15 2 6 18 14 8 0 0.38 1.00 1.00 479 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(3), ATM(15), ATR(5), CCNA1(1), CCNE1(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(3), DHFR(1), GSK3B(1), HDAC1(1), RB1(2), SKP2(1), TGFB2(1), TP53(13) 13376432 52 39 52 29 6 3 18 15 10 0 0.97 1.00 1.00 480 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ACSS2(3), ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADHFE1(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH7A1(2), ALDH9A1(1), ALDOB(1), DLAT(2), DLD(4), ENO1(1), G6PC(1), GALM(2), GAPDHS(1), GPI(1), LDHAL6B(1), LDHB(1), LDHC(2), PDHA1(1), PDHB(1), PFKL(2), PFKM(1), PGAM1(1), PGK1(2), TPI1(2) 25632894 46 39 46 19 2 3 13 18 10 0 0.86 1.00 1.00 481 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(2), ALAS2(2), COX15(1), EPRS(1), FECH(1), FTMT(1), GUSB(2), HCCS(1), HMOX1(2), MMAB(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2A1(3), UGT2A3(4), UGT2B10(7), UGT2B11(2), UGT2B15(1), UGT2B7(2) 18630103 45 39 43 16 7 3 12 19 4 0 0.59 1.00 1.00 482 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(1), EEF1G(1), EIF2AK1(2), EIF2AK2(3), EIF2B1(2), EIF2B2(1), EIF2B5(2), EIF2S1(1), EIF2S2(1), EIF4A2(3), EIF4E(1), EIF4G1(5), EIF4G3(3), EIF5(2), EIF5A(1), ETF1(2), KIAA0664(2), PABPC1(3), PABPC3(1), PAIP1(2), SLC35A4(1) 19334377 40 39 40 15 2 3 10 20 5 0 0.75 1.00 1.00 483 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(4), ELK1(1), GNAS(3), GNB1(2), IGF1R(1), ITGB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), MKNK1(1), MKNK2(2), NGFR(1), PDGFRA(6), PPP2CA(1), PTPRR(2), RPS6KA1(2), SHC1(2), SOS1(4), SRC(1), STAT3(1) 14558350 39 38 39 17 3 2 16 18 0 0 0.83 1.00 1.00 484 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(3), ACO1(5), CLYBL(4), CS(2), DLD(4), DLST(2), FH(1), IDH1(2), IDH3B(2), MDH1(2), OGDH(1), OGDHL(2), PC(1), PCK1(2), PCK2(2), SDHA(1), SDHB(1), SDHD(1), SUCLG1(2), SUCLG2(1) 13074638 41 38 41 14 5 1 12 17 6 0 0.65 1.00 1.00 485 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADHFE1(1), AGPAT6(2), AKR1B1(2), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), CEL(1), DGKB(1), DGKG(2), DGKH(4), DGKI(1), DGKQ(1), DGKZ(2), GK(1), GLB1(4), GPAM(1), LCT(1), LIPC(1), LIPF(1), LPL(1), PNLIP(3), PNPLA3(1), PPAP2B(1) 26006909 42 38 42 18 8 1 14 12 7 0 0.76 1.00 1.00 486 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(1), B3GALT2(2), B3GALT4(1), B3GALT5(1), B3GNT1(1), B3GNT2(2), B3GNT3(1), B3GNT5(1), B4GALT6(1), FUT6(1), GBGT1(2), GCNT2(3), PIGB(1), PIGC(1), PIGG(2), PIGK(1), PIGL(1), PIGM(1), PIGN(2), PIGO(1), PIGP(1), PIGQ(2), PIGT(2), PIGU(1), PIGZ(1), ST3GAL1(1), ST3GAL3(1), ST3GAL5(1), ST6GALNAC5(2), ST8SIA1(1), ST8SIA5(1) 21414365 41 38 41 16 5 1 13 16 6 0 0.76 1.00 1.00 487 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), AKT2(2), AKT3(2), ARHGEF11(2), CDC42(2), DLG4(1), GNA13(2), LPA(2), MAP3K1(3), MAP3K5(4), MAPK8(1), NFKBIL2(2), PDK1(1), PHKA2(1), PIK3CB(2), PLD1(3), PLD3(1), PTK2(1), RDX(1), ROCK1(3), ROCK2(3), TBXA2R(1) 21605664 41 38 41 15 2 4 10 19 6 0 0.65 1.00 1.00 488 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GHR(1), INSR(2), IRS1(3), JAK2(5), MAP2K1(1), MAPK1(1), MAPK3(1), PIK3CA(14), PIK3R1(1), PTPN6(1), RPS6KA1(2), SHC1(2), SOS1(4), STAT5A(2) 14530580 41 37 40 17 4 7 11 17 2 0 0.77 1.00 1.00 489 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(1), C1GALT1(1), C1GALT1C1(1), GALNT1(1), GALNT10(2), GALNT11(2), GALNT13(3), GALNT4(1), GALNT5(5), GALNT7(3), GALNT8(3), GALNT9(1), GALNTL2(1), GALNTL5(2), GCNT1(2), GCNT4(1), OGT(3), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(4) 14184405 40 37 40 17 3 1 12 18 6 0 0.90 1.00 1.00 490 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(1), CARS(2), CARS2(3), DARS(2), EPRS(1), FARSA(1), FARSB(1), GARS(1), IARS(2), IARS2(2), LARS(1), MARS(2), NARS2(4), PARS2(2), QARS(1), RARS2(1), SARS(1), TARS(1), TARS2(2), VARS(2), VARS2(3), WARS2(2), YARS(1) 23879668 40 37 40 13 1 1 14 18 6 0 0.59 1.00 1.00 491 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F11(1), F12(1), F13B(2), F2(2), F5(5), F8(4), FGA(2), FGB(1), FGG(2), LPA(2), PLAT(1), PLAU(4), PLG(1), SERPINF2(2), VWF(6) 15514026 36 36 36 16 5 2 10 14 5 0 0.76 1.00 1.00 492 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(1), APC(6), AXIN1(1), CTNNB1(2), DVL1(1), FZD1(2), GNAI1(2), GSK3B(1), IRAK1(3), LEF1(1), PIK3CA(14), PIK3R1(1), PPP2CA(1), RELA(1), TLR4(1) 13537516 38 36 37 19 1 4 13 15 5 0 0.86 1.00 1.00 493 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(6), AR(1), ESR2(1), ESRRA(1), NPM1(1), NR1H2(2), NR1H3(1), NR1I2(2), NR1I3(1), NR2F2(1), NR4A1(1), NR4A2(1), NR5A2(2), PGR(2), PPARG(1), RARA(4), RARB(1), ROR1(1), RORA(2), RXRB(3), RXRG(1), THRA(3), VDR(1) 18480544 40 36 39 18 5 5 6 13 11 0 0.96 1.00 1.00 494 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 JAK2(5), JUN(1), MAP2K1(1), MAPK3(1), MPL(1), PIK3CA(14), PIK3R1(1), RASA1(2), SHC1(2), SOS1(4), STAT1(2), STAT3(1), STAT5A(2) 13170312 37 36 36 16 3 5 12 15 2 0 0.82 1.00 1.00 495 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(6), ATF2(1), AXIN1(1), BMP5(2), BMP7(1), BMPR2(4), CHRD(2), CTNNB1(2), DVL1(1), FZD1(2), GATA4(1), GSK3B(1), MAP3K7(2), MEF2C(2), MYL2(1), NPPA(1), NPPB(1), RFC1(2), TGFB2(1), TGFBR2(1), TGFBR3(1) 16042319 36 35 36 19 1 3 10 18 4 0 0.93 1.00 1.00 496 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(1), APAF1(1), ATM(15), BID(1), CASP7(1), EIF2S1(1), PTK2(1), PXN(2), STAT1(2), TLN1(6), TP53(13) 12088534 44 35 44 16 3 3 17 13 8 0 0.59 1.00 1.00 497 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(2), CASP7(1), CFLAR(1), DAXX(4), FAF1(1), JUN(1), LMNA(1), MAP3K1(3), MAP3K7(2), MAPK8(1), PAK1(1), PAK2(2), PRKDC(5), PTPN13(7), RB1(2), RIPK2(1), SPTAN1(3) 18427284 39 35 39 18 3 2 12 13 9 0 0.87 1.00 1.00 498 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(4), AGXT(1), ALAS1(2), ALAS2(2), AMT(1), AOC2(1), AOC3(1), BHMT(2), CHKB(1), CTH(1), DAO(1), DLD(4), DMGDH(2), GARS(1), MAOA(1), MAOB(1), PISD(1), PLCB2(1), PLCG2(2), SARDH(2), SARS(1), SHMT1(2), SHMT2(2), TARS(1) 18588201 38 35 38 12 3 3 13 15 4 0 0.52 1.00 1.00 499 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(4), EP300(6), FYN(1), IL7R(1), JAK1(4), JAK3(2), PIK3CA(14), PIK3R1(1), PTK2B(2), STAT5A(2) 12343986 37 35 36 13 1 4 16 13 3 0 0.55 1.00 1.00 500 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(15), ATR(5), CDC25C(2), CHEK1(1), CHEK2(7), TP53(13) 7058116 43 35 40 21 4 2 17 10 10 0 0.92 1.00 1.00 501 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), AKT2(2), AKT3(2), ANKRD6(1), APC(6), AXIN1(1), AXIN2(1), CSNK1A1(1), CTNNB1(2), DACT1(1), DKK1(1), DVL1(1), FSTL1(1), GSK3A(1), GSK3B(1), LRP1(6), MVP(3), NKD1(2), NKD2(1), SFRP1(2) 17829422 37 35 36 21 3 2 14 12 6 0 0.97 1.00 1.00 502 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACADM(1), ACADS(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), AOX1(4), BCKDHA(1), ECHS1(1), EHHADH(2), HADHA(1), HADHB(1), HIBADH(1), IVD(1), MCCC1(2), MCCC2(4), MCEE(1), MUT(2), OXCT1(1), PCCA(2), PCCB(2) 15822732 35 35 34 13 5 1 12 13 4 0 0.59 1.00 1.00 503 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(1), JAK2(5), JUN(1), MAP2K1(1), MAP3K1(3), MAPK3(1), MAPK8(1), PIK3CA(14), PIK3R1(1), SOS1(4), STAT1(2), STAT5A(2) 12334012 36 34 35 14 1 5 12 13 5 0 0.68 1.00 1.00 504 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(1), APC(6), DLG4(1), EPHB2(1), GNAI1(2), ITPR1(2), ITPR2(7), ITPR3(1), KCNJ3(3), MAPK1(1), PITX2(2), RYR1(12) 20291857 39 34 39 20 8 5 9 13 4 0 0.90 1.00 1.00 505 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(1), ATF2(1), CALM1(2), CALM2(1), EGFR(4), ELK1(1), JUN(1), MAP2K1(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(1), MEF2A(2), MEF2C(2), MEF2D(1), PAK1(1), PTK2(1), PTK2B(2), SHC1(2), SOS1(4), SRC(1), SYT1(1) 14786351 36 33 36 13 4 3 16 9 4 0 0.57 1.00 1.00 506 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1B(1), ADH1C(1), ADHFE1(1), AKR1B1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), CEL(1), DGKB(1), DGKG(2), DGKH(4), DGKQ(1), DGKZ(2), GK(1), GLB1(4), LCT(1), LIPC(1), LIPF(1), LPL(1), PNLIP(3), PPAP2B(1) 21381155 36 33 36 14 6 1 13 11 5 0 0.68 1.00 1.00 507 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(1), ARHGAP5(3), ARHGAP6(1), ARHGEF1(1), ARHGEF11(2), ARHGEF5(2), ARPC2(1), ARPC3(1), GSN(1), LIMK1(2), MYL2(1), MYLK(3), OPHN1(1), PPP1R12B(1), ROCK1(3), SRC(1), TLN1(6), VCL(1) 20117723 34 33 34 13 1 2 9 19 3 0 0.76 1.00 1.00 508 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(1), BID(1), BIRC2(2), BIRC3(2), CASP2(2), CASP7(1), FAS(3), JUN(1), MAP3K1(3), MAP3K14(1), MAPK10(2), PARP1(2), RELA(1), RIPK1(2), TNFRSF1A(2), TP53(13), TRADD(1) 16502814 40 32 40 14 2 5 15 12 6 0 0.50 1.00 1.00 509 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), CALM1(2), CALM2(1), ELK1(1), JUN(1), LYN(1), MAP2K1(1), MAP3K1(3), MAPK14(1), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), PPP3CB(1), PPP3CC(2), SHC1(2), SOS1(4), SYK(1), SYT1(1), VAV1(2) 16805232 36 32 36 18 6 2 12 10 6 0 0.90 1.00 1.00 510 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(1), AKT1(1), GNAI1(2), GNB1(2), MAPK1(1), MAPK3(1), PDGFA(1), PDGFRA(6), PIK3CA(14), PIK3R1(1), PLCB1(1), PTK2(1), SMPD1(1), SRC(1) 12069374 34 32 33 17 1 3 11 16 3 0 0.93 1.00 1.00 511 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ARG1(1), ASS1(1), CPS1(5), DAO(1), EPRS(1), GLUD1(2), GOT1(2), GOT2(3), LAP3(2), NOS1(7), NOS3(1), OTC(1), P4HA2(1), P4HA3(1), PARS2(2), PYCR1(1), PYCR2(1), RARS2(1) 15821959 34 32 34 18 2 0 13 15 4 0 0.97 1.00 1.00 512 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX15B(2), ALOX5(1), CBR1(2), CYP2B6(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(2), CYP2J2(1), CYP4A11(4), CYP4F2(1), DHRS4(2), EPHX2(1), GGT1(1), GPX3(1), GPX4(1), GPX6(1), LTA4H(3), PLA2G12A(1), PLA2G6(1), PTGDS(1), PTGES(1), PTGS2(4), TBXAS1(1) 17144945 36 32 36 18 4 5 8 14 5 0 0.94 1.00 1.00 513 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(3), ITGB1(2), KLRC1(2), KLRC2(2), KLRC3(1), KLRD1(1), MAP2K1(1), MAPK3(1), PAK1(1), PIK3CA(14), PIK3R1(1), PTK2B(2), PTPN6(1), SYK(1), VAV1(2) 8184482 35 32 33 11 3 4 13 11 4 0 0.46 1.00 1.00 514 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(15), BMPR1B(1), CCND2(1), CDK4(1), EGR1(1), ESR2(1), LHCGR(1), NCOR1(6), NRIP1(3), PGR(2), PRLR(2), PTGER2(1), SMPD1(1), VDR(1), ZP2(1) 15425058 38 32 38 15 3 0 15 11 9 0 0.69 1.00 1.00 515 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(7), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), ECHS1(1), EHHADH(2), HADHA(1), LDHB(1), LDHC(2), MCEE(1), MLYCD(1), MUT(2), PCCA(2), PCCB(2), SUCLG1(2), SUCLG2(1) 14523472 33 32 33 14 3 4 14 8 4 0 0.66 1.00 1.00 516 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(3), CREBBP(4), EP300(6), ERCC3(1), GRIP1(1), GTF2A1(1), GTF2F1(1), HDAC1(1), HDAC4(1), HDAC6(2), MEF2C(2), NCOR2(3), NRIP1(3), POLR2A(5), SRA1(1) 20365024 35 31 35 28 0 4 15 13 3 0 1.00 1.00 1.00 517 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(1), DLAT(2), DLD(4), ENO1(1), G6PC(1), GAPDHS(1), GOT1(2), GOT2(3), GPI(1), LDHAL6B(1), LDHB(1), LDHC(2), MDH1(2), PC(1), PCK1(2), PDHA1(1), PDHB(1), PDHX(1), PFKL(2), PFKM(1), PGAM1(1), PGK1(2), TPI1(2) 18679836 36 31 36 17 2 2 11 13 8 0 0.91 1.00 1.00 518 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(3), ALDOB(1), FPGT(3), FUK(1), GMDS(1), GMPPB(2), KHK(3), MTMR1(3), MTMR2(1), MTMR6(2), PFKFB2(1), PFKFB3(1), PFKL(2), PFKM(1), PGM2(1), RDH11(2), TPI1(2) 16515649 32 31 32 18 2 4 11 9 6 0 0.94 1.00 1.00 519 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(4), ADCY3(1), ADCY9(3), ARF1(1), ARF5(1), ARF6(1), ATP6V0A1(3), ATP6V0A4(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1C1(2), ERO1L(1), GNAS(3), PLCG2(2), SEC61A2(1), SEC61B(1), SEC61G(1), TRIM23(3) 16250849 33 31 33 17 3 2 10 17 1 0 0.95 1.00 1.00 520 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 ELK1(1), IGF1(1), IGF1R(1), IRS1(3), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(1), PIK3CA(14), PIK3R1(1), PTPN11(1), RASA1(2), SHC1(2), SOS1(4) 10880709 34 31 33 16 3 3 15 12 1 0 0.81 1.00 1.00 521 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(1), ARHGEF1(1), F2(2), GNA13(2), GNAI1(2), GNB1(2), MAP3K7(2), PIK3CA(14), PIK3R1(1), PLCB1(1), PPP1R12B(1), PTK2B(2), ROCK1(3) 11405477 34 31 33 12 1 2 12 14 5 0 0.59 1.00 1.00 522 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(3), CDKN2A(3), PIK3CA(14), PIK3R1(1), POLR1A(1), POLR1B(2), RB1(2), TP53(13) 8973004 39 30 38 20 4 4 17 12 2 0 0.86 1.00 1.00 523 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(1), CALM1(2), CALM2(1), ELK1(1), GNAI1(2), GNAS(3), GNB1(2), JUN(1), MAP2K1(1), MAPK3(1), NFATC1(1), NFATC2(2), NFATC3(3), NFATC4(2), PPP3CB(1), PPP3CC(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2), SYT1(1) 15353941 33 30 33 15 6 1 9 14 3 0 0.88 1.00 1.00 524 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 ELK1(1), INSR(2), IRS1(3), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(1), PIK3CA(14), PIK3R1(1), PTPN11(1), RASA1(2), SHC1(2), SOS1(4) 11202370 34 30 33 13 3 4 14 12 1 0 0.58 1.00 1.00 525 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(6), AXIN1(1), CREBBP(4), CTNNB1(2), DVL1(1), EP300(6), FZD1(2), GSK3B(1), HDAC1(1), LEF1(1), PITX2(2), TRRAP(6) 14585886 33 30 33 19 1 3 12 15 2 0 0.94 1.00 1.00 526 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CASP2(2), JUN(1), LMNA(1), MADD(2), MAP3K1(3), MAP3K7(2), MAPK8(1), PAK1(1), PAK2(2), PRKDC(5), RB1(2), RIPK1(2), SPTAN1(3), TNFRSF1A(2), TRADD(1) 17386573 32 30 32 17 2 3 13 7 7 0 0.89 1.00 1.00 527 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(2), CXCR4(1), GNAI1(2), GNB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), PIK3C2G(1), PIK3CA(14), PIK3R1(1), PTK2(1), PTK2B(2), PXN(2), RELA(1) 12269241 32 29 31 15 1 4 12 12 3 0 0.85 1.00 1.00 528 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(1), ADH1C(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOB(1), DLAT(2), DLD(4), ENO1(1), G6PC(1), GPI(1), LDHB(1), LDHC(2), PDHA1(1), PDHB(1), PFKM(1), PGAM1(1), PGK1(2), TPI1(2) 21484939 34 29 34 19 1 2 10 15 6 0 0.98 1.00 1.00 529 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(1), ADH1C(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOB(1), DLAT(2), DLD(4), ENO1(1), G6PC(1), GPI(1), LDHB(1), LDHC(2), PDHA1(1), PDHB(1), PFKM(1), PGAM1(1), PGK1(2), TPI1(2) 21484939 34 29 34 19 1 2 10 15 6 0 0.98 1.00 1.00 530 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(1), AKT1(1), CSF2RB(1), IGF1(1), IGF1R(1), IL3(1), IL3RA(1), KITLG(2), PIK3CA(14), PIK3R1(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2) 9624143 30 28 29 12 3 2 11 13 1 0 0.65 1.00 1.00 531 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(1), AKT1(1), CALM1(2), CALM2(1), GNAS(3), GNB1(2), NOS3(1), NPPA(1), PIK3CA(14), PIK3R1(1), RELA(1), SYT1(1) 7869145 29 28 28 10 1 2 11 14 1 0 0.67 1.00 1.00 532 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(4), ACY1(1), AGMAT(2), ALDH18A1(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(1), ARG1(1), ASS1(1), CPS1(5), MAOA(1), MAOB(1), OTC(1), SAT1(1), SMS(2) 13025380 30 28 30 14 1 1 13 11 4 0 0.89 1.00 1.00 533 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10(1), ALG10B(2), ALG13(3), ALG2(1), ALG5(1), ALG8(2), DDOST(1), DOLPP1(1), DPAGT1(2), GANAB(1), MAN2A1(2), MGAT3(1), MGAT4A(3), MGAT5(3), MGAT5B(1), RFT1(1), RPN1(1), RPN2(2), STT3B(2) 18735926 31 28 31 13 3 1 8 18 1 0 0.81 1.00 1.00 534 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 CS(2), DLAT(2), DLD(4), DLST(2), FH(1), IDH3B(2), MDH1(2), OGDH(1), PC(1), PDHA1(1), PDHB(1), PDHX(1), PDK1(1), PDK2(1), PDK3(1), PDP2(1), SDHA(1), SDHB(1), SDHD(1), SUCLG1(2), SUCLG2(1) 12466556 30 28 30 12 1 0 11 13 5 0 0.80 1.00 1.00 535 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(4), DAXX(4), PML(1), RARA(4), RB1(2), SIRT1(2), SP100(1), TNFRSF1A(2), TP53(13) 8469884 33 28 33 17 3 3 15 10 2 0 0.86 1.00 1.00 536 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(1), ERCC3(1), GTF2A2(1), GTF2E2(2), GTF2F2(1), GTF2H1(1), POLR1A(1), POLR1B(2), POLR2A(5), POLR2B(4), POLR2F(1), POLR2I(1), POLR3B(4), POLR3E(1), POLR3H(1), TAF5(2), TAF9(1) 15387357 30 28 28 20 2 3 10 11 4 0 0.99 1.00 1.00 537 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BLNK(2), ELK1(1), JUN(1), LYN(1), MAP2K1(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8IP3(1), PAPPA(1), RPS6KA1(2), SHC1(2), SOS1(4), SYK(1), VAV1(2), VAV2(3), VAV3(2) 14146516 30 28 30 10 4 3 9 9 5 0 0.46 1.00 1.00 538 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ABP1(4), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH9A1(1), AOC2(1), AOC3(1), CNDP1(3), DPYD(1), DPYS(1), ECHS1(1), EHHADH(2), GAD1(1), HADHA(1), MLYCD(1), SMS(2), UPB1(1) 12788579 28 27 28 14 4 2 11 9 2 0 0.83 1.00 1.00 539 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ABP1(4), ACADM(1), ALDH1B1(1), ALDH2(1), ALDH3A2(1), ALDH7A1(2), ALDH9A1(1), AOC2(1), AOC3(1), CNDP1(3), DPYD(1), DPYS(1), ECHS1(1), EHHADH(2), GAD1(1), HADHA(1), MLYCD(1), SMS(2), UPB1(1) 11901083 28 27 28 12 4 2 10 8 4 0 0.69 1.00 1.00 540 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(1), IGF1R(1), IRS1(3), MAP2K1(1), MAPK1(1), MAPK3(1), PIK3CA(14), PIK3R1(1), SHC1(2), SOS1(4) 8299856 29 27 28 10 3 4 10 11 1 0 0.52 1.00 1.00 541 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(1), EGFR(4), IGF1R(1), POLR2A(5), PPP2CA(1), RB1(2), TEP1(1), TERT(3), TNKS(2), TP53(13), XRCC5(2) 12428925 35 27 35 22 3 3 20 6 3 0 0.93 1.00 1.00 542 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(1), ABAT(1), ADSL(1), AGXT(1), ASS1(1), CAD(2), CRAT(1), DARS(2), DLAT(2), DLD(4), GAD1(1), GOT1(2), GOT2(3), GPT2(1), NARS2(4), PC(1), PDHA1(1), PDHB(1) 16640716 31 26 31 15 4 1 6 11 9 0 0.94 1.00 1.00 543 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(1), ATM(15), CCNE1(1), CDK2(1), CDK4(1), CDKN1A(1), PCNA(2), RB1(2), TP53(13) 8015715 37 26 37 18 3 2 15 8 9 0 0.86 1.00 1.00 544 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(15), CDC25A(1), CDC25C(2), CDK2(1), CDK4(1), CHEK1(1), RB1(2), TP53(13) 7763036 36 26 36 22 3 2 13 8 10 0 0.98 1.00 1.00 545 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(6), CDH1(3), CREBBP(4), EP300(6), MAP2K1(1), MAP3K7(2), MAPK3(1), SKIL(1), TGFB2(1), TGFBR2(1) 11247652 26 26 26 14 2 3 12 7 2 0 0.81 1.00 1.00 546 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(2), CSF1R(2), EGF(3), EGFR(4), MET(5), PDGFRA(6), SH3GLB1(1), SH3GLB2(1), SRC(1) 8519214 25 25 25 10 0 0 10 12 3 0 0.83 1.00 1.00 547 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 AGPS(1), CDS2(1), CHAT(2), CHKB(1), CLC(1), DGKB(1), DGKG(2), DGKH(4), DGKQ(1), DGKZ(2), ETNK1(1), GNPAT(2), LYPLA1(1), PAFAH1B1(1), PAFAH2(2), PCYT1B(1), PISD(1), PLA2G6(1), PLCB2(1), PLCG2(2), PPAP2B(1) 22161028 30 25 30 16 6 3 8 11 2 0 0.88 1.00 1.00 548 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(1), MAP2K1(1), MAP2K3(2), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), PIK3CA(14), PIK3R1(1), RB1(2), RELA(1), SP1(1) 8553846 29 25 28 10 2 4 10 8 5 0 0.46 1.00 1.00 549 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), CAD(2), CPS1(5), EPRS(1), GAD1(1), GFPT2(2), GLS(1), GLS2(1), GLUD1(2), GOT1(2), GOT2(3), GPT2(1), GSR(1), GSS(1), NAGK(2), QARS(1) 17404044 27 25 27 11 4 0 13 7 3 0 0.65 1.00 1.00 550 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(1), CCNE1(1), CDK2(1), CDK4(1), CDKN1A(1), MAPK1(1), MAPK3(1), PAK1(1), PIK3CA(14), PIK3R1(1), RB1(2), RELA(1) 8904595 26 25 25 11 2 3 11 8 2 0 0.69 1.00 1.00 551 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(3), G6PC(1), GAA(2), GALE(1), GALK1(1), GALK2(2), GALT(2), GANC(1), GLB1(4), LCT(1), PFKL(2), PFKM(1), RDH11(2) 17113423 25 24 25 12 2 2 6 11 4 0 0.91 1.00 1.00 552 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(1), ADRB2(1), CHRM2(3), CHRM3(2), CHRM5(1), DRD1(1), DRD2(1), DRD3(1), DRD5(3), HTR1A(2), HTR1E(3), HTR2A(2), HTR2C(1), HTR5A(1), HTR7(1) 11257262 24 24 24 11 5 3 2 13 1 0 0.86 1.00 1.00 553 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(2), ACTN2(2), ACTN3(1), CAPN1(1), ITGA1(4), ITGB1(2), PTK2(1), PXN(2), SPTAN1(3), SRC(1), TLN1(6) 12524557 25 24 25 10 2 2 8 9 4 0 0.85 1.00 1.00 554 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 ELK1(1), IL2RA(2), IL2RB(1), JAK1(4), JAK3(2), JUN(1), MAP2K1(1), MAPK3(1), MAPK8(1), SHC1(2), SOS1(4), STAT5A(2), SYK(1) 10346138 23 23 23 12 4 2 7 7 3 0 0.90 1.00 1.00 555 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(1), CAT(2), GH1(1), GHR(1), IGF1(1), IGF1R(1), PIK3CA(14), PIK3R1(1), SHC1(2), SOD2(1) 5820422 25 23 24 11 1 2 10 11 1 0 0.78 1.00 1.00 556 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(2), CALM1(2), CALM2(1), JUN(1), MAP2K1(1), MAP2K3(2), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(1), PAK1(1), PTK2B(2), SHC1(2), SOS1(4), SRC(1), SYT1(1) 12515899 27 23 27 14 4 2 9 8 4 0 0.91 1.00 1.00 557 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), ATF1(1), CDC42(2), DUSP10(1), EIF4E(1), ELK1(1), MAP2K3(2), MAP3K10(2), MAP3K4(5), MAP3K5(4), MAP3K7(2), MAPK1(1), MAPK12(1), MAPK13(1), MAPK14(1), MKNK1(1), MKNK2(2), TRAF6(1) 14673799 30 23 30 13 2 2 7 15 4 0 0.87 1.00 1.00 558 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 IFNGR1(1), IKBKB(1), JAK2(5), RB1(2), RELA(1), TNFRSF1A(2), TP53(13), USH1C(1), WT1(3) 8118921 29 23 29 16 2 3 13 7 4 0 0.90 1.00 1.00 559 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(6), AXIN1(1), CREBBP(4), CSNK1A1(1), CTBP1(1), CTNNB1(2), DVL1(1), FZD1(2), GSK3B(1), HDAC1(1), MAP3K7(2), PPP2CA(1), TLE1(2) 12986296 25 23 25 16 1 2 10 9 3 0 0.95 1.00 1.00 560 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), ARSB(3), ARSE(1), CYP11B2(2), HSD17B8(1), HSD3B1(1), SRD5A1(1), STS(1), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2B15(1) 12067228 24 22 24 10 1 4 7 8 4 0 0.71 1.00 1.00 561 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSE(1), B4GALT6(1), DEGS1(3), ENPP7(2), GAL3ST1(2), GALC(1), GBA(1), GLB1(4), LCT(1), NEU1(1), NEU3(1), PPAP2B(1), SGPP1(1), SGPP2(2), SMPD1(1), SPHK2(1) 15841416 24 22 24 10 2 0 6 11 5 0 0.81 1.00 1.00 562 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 DLG4(1), EPHB2(1), F2(2), F2RL2(1), JUN(1), MAPK1(1), MAPK7(1), MAPK8(1), PLD1(3), PLD3(1), PTK2(1), RASAL1(2), SRC(1), TEC(3), VAV1(2) 12088879 22 22 22 11 5 2 4 10 1 0 0.92 1.00 1.00 563 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN2(2), ACTN3(1), BCAR1(2), CSK(2), CTNNA1(4), CTNNA2(3), CTNNB1(2), PTK2(1), PXN(2), SRC(1), VCL(1) 8408858 23 21 23 13 3 0 8 8 4 0 0.96 1.00 1.00 564 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BRAF(5), DUSP9(1), EIF4E(1), MAP2K1(1), MAPK1(1), MAPK3(1), MKNK1(1), MKNK2(2), RPS6KA1(2), RPS6KA2(1), SHC1(2), SOS1(4), SOS2(1) 13025622 24 21 24 13 3 3 6 8 4 0 0.95 1.00 1.00 565 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(6), EPHB2(1), ITPKA(1), ITPKB(2), JUN(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK8(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(1) 12574915 21 21 21 21 4 3 6 6 2 0 1.00 1.00 1.00 566 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), PGAP1(2), PIGB(1), PIGC(1), PIGG(2), PIGK(1), PIGL(1), PIGM(1), PIGN(2), PIGO(1), PIGP(1), PIGQ(2), PIGT(2), PIGU(1), PIGZ(1) 10594615 20 20 20 10 2 2 5 9 2 0 0.90 1.00 1.00 567 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(3), ALOX5(1), CYP1A2(2), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(2), CYP2J2(1), CYP3A4(1), CYP3A43(1), CYP3A5(1), CYP3A7(1), PLA2G12A(1), PLA2G6(1), RDH11(2) 10519362 20 20 20 11 3 2 6 8 1 0 0.89 1.00 1.00 568 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2A1(1), GTF2F1(1), NCOA1(2), NCOA2(2), NCOA3(4), NCOR2(3), POLR2A(5), RARA(4) 11001556 23 20 23 19 0 3 8 8 4 0 0.99 1.00 1.00 569 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(3), PRB1(4), TP53(13) 3754793 24 20 23 11 3 2 9 6 4 0 0.71 1.00 1.00 570 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 GNAS(3), GNB1(2), LIMK1(2), MAP2K1(1), MAPK1(1), MAPK3(1), MYL2(1), NOX1(2), PIK3C2G(1), PLCB1(1), PPP1R12B(1), PTK2(1), ROCK2(3) 11193652 20 19 20 12 1 3 4 11 1 0 0.98 1.00 1.00 571 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 JAK1(4), JAK2(5), JAK3(2), STAT1(2), STAT3(1), STAT5A(2), TYK2(3) 8147330 19 18 19 11 1 2 5 8 3 0 0.97 1.00 1.00 572 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 EPRS(1), FECH(1), GUSB(2), HCCS(1), HMOX1(2), UGT1A10(1), UGT1A3(1), UGT1A4(2), UGT1A6(1), UGT1A7(4), UGT1A8(2), UGT1A9(1), UGT2B15(1) 12041487 20 18 20 10 3 3 4 8 2 0 0.87 1.00 1.00 573 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(2), GNAI1(2), GNB1(2), ITGA1(4), ITGB1(2), MAP2K1(1), MAPK1(1), MAPK3(1), PLCB1(1), PTK2(1), SRC(1), SYK(1), TBXAS1(1) 10706616 20 18 20 15 2 4 5 5 4 0 0.99 1.00 1.00 574 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), CARS(2), DARS(2), EPRS(1), GARS(1), IARS(2), LARS(1), MARS(2), QARS(1), SARS(1), TARS(1), WARS2(2), YARS(1) 14080637 18 17 18 10 0 1 6 9 2 0 0.94 1.00 1.00 575 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), G6PC(1), GAA(2), GALE(1), GALK1(1), GALK2(2), GALT(2), GANAB(1), GLB1(4), LCT(1), PFKM(1) 14411295 18 17 18 11 0 1 4 9 4 0 0.98 1.00 1.00 576 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(1), G6PD(1), GPI(1), H6PD(2), PFKL(2), PFKM(1), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(1), TALDO1(1), TKTL1(1), TKTL2(2) 10731947 17 17 17 11 1 0 8 7 1 0 0.95 1.00 1.00 577 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), CA12(1), CA14(2), CA5B(1), CA7(1), CA9(1), CPS1(5), CTH(1), GLS(1), GLS2(1), GLUD1(2) 9356419 17 17 17 9 1 1 8 7 0 0 0.83 1.00 1.00 578 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), CA12(1), CA14(2), CA5B(1), CA7(1), CA9(1), CPS1(5), CTH(1), GLS(1), GLS2(1), GLUD1(2) 8362467 17 17 17 7 1 1 8 7 0 0 0.67 1.00 1.00 579 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(6), AXIN1(1), CTNNB1(2), DVL1(1), FZD1(2), GSK3B(1), NOTCH1(4) 9443310 17 17 17 14 1 2 6 5 3 0 0.99 1.00 1.00 580 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOB(1), FPGT(3), GMDS(1), GMPPB(2), KHK(3), PFKFB3(1), PFKM(1), TPI1(2) 10595715 16 16 16 15 0 3 6 4 3 0 1.00 1.00 1.00 581 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT6(2), AGPS(1), CHPT1(1), ENPP2(3), PAFAH1B1(1), PAFAH1B2(1), PAFAH2(2), PLA2G12A(1), PLA2G6(1), PLD1(3), PPAP2B(1) 10229782 17 16 17 9 1 1 6 9 0 0 0.89 1.00 1.00 582 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(1), CASP1(1), CASP7(1), INSR(2), MAGI1(2), MAGI2(5), RERE(2), WWP1(1), WWP2(1) 10572880 16 16 16 13 3 2 2 5 4 0 1.00 1.00 1.00 583 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(15), CDC25A(1), CDC25C(2), CHEK1(1) 6049255 19 15 19 12 0 0 4 7 8 0 0.98 1.00 1.00 584 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(1), ADRB2(1), CFTR(4), GNAS(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2) 5728492 15 14 15 6 2 0 4 9 0 0 0.83 1.00 1.00 585 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(1), F2(2), FGA(2), FGB(1), FGG(2), PLAT(1), PLAU(4), PLG(1) 5892597 14 14 14 10 2 1 3 6 2 0 0.97 1.00 1.00 586 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(3), G6PD(1), GGT1(1), GPX3(1), GPX4(1), GPX6(1), GSR(1), GSS(1), GSTA3(1), IDH1(2), TXNDC12(1) 9590325 14 14 14 10 0 0 4 7 3 0 0.99 1.00 1.00 587 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(5), HMGCR(1), LIPC(1), LPL(1), LRP1(6) 12021814 14 14 14 10 2 0 3 8 1 0 0.99 1.00 1.00 588 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCND2(1), CCNE1(1), CCNH(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(3), CDKN2C(1), RB1(2) 7150139 14 13 14 12 1 0 4 7 2 0 0.99 1.00 1.00 589 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 JUN(1), KEAP1(3), MAPK1(1), MAPK14(1), MAPK8(1), NFE2L2(5) 3908466 12 12 12 5 0 1 5 6 0 0 0.75 1.00 1.00 590 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1), CREM(1), FHL5(2), GNAS(3), XPO1(5) 4181801 12 12 12 5 2 0 5 5 0 0 0.78 1.00 1.00 591 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 COASY(2), DPYD(1), DPYS(1), ENPP3(2), ILVBL(1), PANK1(1), PANK2(2), PANK3(1), UPB1(1), VNN1(1) 7610921 13 12 13 11 1 0 3 6 3 0 0.98 1.00 1.00 592 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(1), G6PD(1), GPI(1), H6PD(2), PFKM(1), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(1), TALDO1(1) 8999659 12 12 12 10 0 0 6 5 1 0 0.98 1.00 1.00 593 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(1), FYN(1), LRP8(1), RELN(5), VLDLR(4) 6162508 12 12 12 6 1 0 5 6 0 0 0.86 1.00 1.00 594 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(3), GNB1(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR2B(2) 4200655 11 11 11 5 2 0 2 7 0 0 0.87 1.00 1.00 595 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(7), NRG2(2), NRG3(2) 3959285 11 11 11 5 1 1 4 5 0 0 0.74 1.00 1.00 596 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(3), G6PD(1), GGT1(1), GPX3(1), GPX4(1), GSS(1), GSTA3(1), IDH1(2) 7937520 11 11 11 11 0 0 2 7 2 0 1.00 1.00 1.00 597 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDK2(1), CUL1(3), FBXW7(4), RB1(2) 3689521 11 10 11 10 0 1 5 3 2 0 0.99 1.00 1.00 598 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 KHK(3), LCT(1), PYGL(1), PYGM(2), TPI1(2), TREH(1) 5892890 10 10 10 5 1 2 5 2 0 0 0.78 1.00 1.00 599 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(2), CALM2(1), CCL2(1), CXCR4(1), JUN(1), MAPK14(1), MAPK8(1), PTK2B(2), SYT1(1) 6038254 11 9 11 6 1 0 6 4 0 0 0.85 1.00 1.00 600 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 GOSR1(1), SEC22B(1), SNAP25(1), STX19(1), STX2(1), STX7(1), STX8(1), TSNARE1(2) 7408198 9 9 9 6 1 0 4 4 0 0 0.92 1.00 1.00 601 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(1), GNAS(3), GNB1(2), PRKACA(1), PRKAR1A(1) 2876369 8 8 8 5 0 0 2 6 0 0 0.95 1.00 1.00 602 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX3(3), FADS2(2), PLA2G12A(1), PLA2G6(1) 4484190 7 7 7 6 2 3 0 2 0 0 0.95 1.00 1.00 603 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(4), GZMA(1), HMGB2(1) 4667730 6 6 6 4 0 0 4 2 0 0 0.86 1.00 1.00 604 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(1), CDC25C(2), CSK(2), SRC(1) 4035181 6 6 6 6 0 0 2 4 0 0 0.98 1.00 1.00 605 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(5), MAPK1(1), SRC(1) 5020499 7 6 7 13 0 2 4 0 1 0 1.00 1.00 1.00 606 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADM(1), ACADS(2), ECHS1(1), HADHA(1) 2375738 5 5 4 4 3 0 2 0 0 0 0.80 1.00 1.00 607 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(3), SNCAIP(1), UBE2E2(1) 2811271 5 5 5 5 2 0 3 0 0 0 0.94 1.00 1.00 608 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), NR1H3(1), NR1H4(1) 2403800 3 3 3 5 0 0 1 2 0 0 1.00 1.00 1.00 609 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PTK2B(2) 2944597 3 3 3 4 0 0 2 1 0 0 0.98 1.00 1.00 610 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 IMPA2(1), TGDS(1) 5142863 2 2 2 5 0 0 1 1 0 0 1.00 1.00 1.00 611 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(1), LPL(1) 2339968 2 2 2 2 0 0 1 1 0 0 0.95 1.00 1.00 612 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(1), PPARG(1) 2549168 2 2 2 6 1 0 1 0 0 0 1.00 1.00 1.00 613 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(1) 2180368 1 1 1 3 1 0 0 0 0 0 0.99 1.00 1.00 614 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 TGDS(1) 4509713 1 1 1 4 0 0 1 0 0 0 1.00 1.00 1.00 615 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 222094 0 0 0 0 0 0 0 0 0 0 1.00 1.00 1.00 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 670538 0 0 0 2 0 0 0 0 0 0 1.00 1.00 1.00