E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.133 0.215 -9999.0 0.0 -0.42 9.0 9.0 KLHL20 -0.03 0.1 0.212 1.0 -0.225 1.0 2.0 CYFIP2 0.033 0.035 -9999.0 0.0 -0.144 1.0 1.0 Rac1/GDP -0.067 0.139 -9999.0 0.0 -0.252 9.0 9.0 ENAH -0.133 0.214 -9999.0 0.0 -0.403 10.0 10.0 AP1M1 0.034 0.014 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.04 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.018 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.008 0.107 -9999.0 0.0 -0.37 2.0 2.0 CDC42/GTP -0.041 0.104 -9999.0 0.0 -0.24 2.0 2.0 ABI1/Sra1/Nap1 -0.036 0.043 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.02 0.152 -9999.0 0.0 -0.225 9.0 9.0 RAPGEF1 -0.118 0.199 -9999.0 0.0 -0.383 9.0 9.0 CTNND1 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.136 0.23 -9999.0 0.0 -0.429 10.0 10.0 CRK -0.125 0.215 -9999.0 0.0 -0.397 10.0 10.0 E-cadherin/gamma catenin/alpha catenin -0.043 0.13 -9999.0 0.0 -0.219 8.0 8.0 alphaE/beta7 Integrin 0.057 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.039 0.059 -9999.0 0.0 -0.197 1.0 1.0 DLG1 -0.139 0.22 -9999.0 0.0 -0.419 10.0 10.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.047 0.061 -9999.0 0.0 -0.149 1.0 1.0 MLLT4 0.022 0.078 -9999.0 0.0 -0.37 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.064 0.053 -9999.0 0.0 -0.197 1.0 1.0 PI3K -0.056 0.079 -9999.0 0.0 -0.189 1.0 1.0 ARF6 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.069 0.137 -9999.0 0.0 -0.26 8.0 8.0 TIAM1 0.025 0.078 -9999.0 0.0 -0.37 1.0 1.0 E-cadherin(dimer)/Ca2+ -0.019 0.142 -9999.0 0.0 -0.211 9.0 9.0 AKT1 -0.026 0.064 0.167 1.0 -9999.0 0.0 1.0 PIK3R1 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.122 0.176 -9999.0 0.0 -0.273 14.0 14.0 RhoA/GDP -0.055 0.145 -9999.0 0.0 -0.252 9.0 9.0 actin cytoskeleton organization -0.021 0.078 0.177 1.0 -0.164 1.0 2.0 CDC42/GDP -0.067 0.137 -9999.0 0.0 -0.258 6.0 6.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.047 0.098 -9999.0 0.0 -0.195 8.0 8.0 ITGB7 0.04 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.037 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.02 0.152 -9999.0 0.0 -0.225 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.046 0.128 -9999.0 0.0 -0.209 9.0 9.0 mol:GDP -0.085 0.153 -9999.0 0.0 -0.288 9.0 9.0 CDC42/GTP/IQGAP1 0.038 0.025 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.04 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.057 0.152 -9999.0 0.0 -0.258 9.0 9.0 RAC1/GTP/IQGAP1 0.048 0.017 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.051 0.021 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.037 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.03 0.018 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.04 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.012 0.06 0.134 1.0 -0.163 1.0 2.0 NME1 0.04 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.139 0.22 -9999.0 0.0 -0.419 10.0 10.0 regulation of cell-cell adhesion -0.045 0.086 -9999.0 0.0 -0.212 2.0 2.0 WASF2 0.0 0.037 0.109 1.0 -9999.0 0.0 1.0 Rap1/GTP -0.055 0.114 -9999.0 0.0 -0.267 2.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.018 0.136 -9999.0 0.0 -0.188 8.0 8.0 CCND1 -0.015 0.072 0.154 1.0 -0.201 1.0 2.0 VAV2 -0.101 0.215 -9999.0 0.0 -0.549 1.0 1.0 RAP1/GDP -0.051 0.123 -9999.0 0.0 -0.27 2.0 2.0 adherens junction assembly -0.134 0.213 -9999.0 0.0 -0.406 10.0 10.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.036 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.036 0.013 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.039 0.135 -9999.0 0.0 -0.291 2.0 2.0 E-cadherin/beta catenin -0.07 0.136 -9999.0 0.0 -0.297 7.0 7.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.139 0.22 -9999.0 0.0 -0.419 10.0 10.0 PIK3CA 0.037 0.011 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.087 0.105 -9999.0 0.0 -0.361 1.0 1.0 E-cadherin/beta catenin/alpha catenin -0.057 0.15 -9999.0 0.0 -0.247 9.0 9.0 ITGAE 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.14 0.235 -9999.0 0.0 -0.438 10.0 10.0