E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.031 0.147 -9999.0 0.0 -0.417 14.0 14.0 KLHL20 -0.01 0.112 0.189 1.0 -0.307 11.0 12.0 CYFIP2 0.028 0.048 -9999.0 0.0 -0.506 1.0 1.0 Rac1/GDP 0.004 0.111 0.248 1.0 -0.295 8.0 9.0 ENAH -0.031 0.15 -9999.0 0.0 -0.411 15.0 15.0 AP1M1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.062 -9999.0 0.0 -0.506 2.0 2.0 CTNNB1 0.031 0.019 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.015 0.08 -9999.0 0.0 -0.291 1.0 1.0 ABI1/Sra1/Nap1 -0.033 0.061 -9999.0 0.0 -0.207 11.0 11.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.06 0.082 -9999.0 0.0 -0.287 6.0 6.0 RAPGEF1 -0.018 0.129 -9999.0 0.0 -0.414 8.0 8.0 CTNND1 0.02 0.096 -9999.0 0.0 -0.506 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.024 0.157 -9999.0 0.0 -0.42 15.0 15.0 CRK -0.014 0.135 -9999.0 0.0 -0.422 10.0 10.0 E-cadherin/gamma catenin/alpha catenin 0.023 0.126 -9999.0 0.0 -0.331 16.0 16.0 alphaE/beta7 Integrin 0.05 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.036 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.03 0.049 -9999.0 0.0 -0.506 1.0 1.0 Rap1/GTP/I-afadin 0.057 0.047 -9999.0 0.0 -0.286 2.0 2.0 DLG1 -0.033 0.151 -9999.0 0.0 -0.412 15.0 15.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.014 0.049 -9999.0 0.0 -0.235 4.0 4.0 MLLT4 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.059 0.047 -9999.0 0.0 -0.286 2.0 2.0 PI3K -0.015 0.065 -9999.0 0.0 -0.308 4.0 4.0 ARF6 0.028 0.063 -9999.0 0.0 -0.506 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.002 0.136 -9999.0 0.0 -0.387 16.0 16.0 TIAM1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.046 0.095 -9999.0 0.0 -0.268 11.0 11.0 AKT1 0.035 0.072 0.165 5.0 -0.232 3.0 8.0 PIK3R1 0.01 0.091 -9999.0 0.0 -0.506 4.0 4.0 CDH1 0.013 0.106 -9999.0 0.0 -0.506 6.0 6.0 RhoA/GDP 0.008 0.109 0.25 1.0 -0.294 7.0 8.0 actin cytoskeleton organization -0.005 0.083 0.147 3.0 -0.217 11.0 14.0 CDC42/GDP 0.005 0.112 0.25 1.0 -0.294 8.0 9.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.016 0.111 -9999.0 0.0 -0.283 20.0 20.0 ITGB7 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.05 0.102 -9999.0 0.0 -0.285 11.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.069 -9999.0 0.0 -0.267 6.0 6.0 mol:GDP -0.015 0.118 0.249 1.0 -0.339 8.0 9.0 CDC42/GTP/IQGAP1 0.048 0.012 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.004 0.14 -9999.0 0.0 -0.506 11.0 11.0 p120 catenin/RhoA/GDP 0.012 0.119 0.262 1.0 -0.304 7.0 8.0 RAC1/GTP/IQGAP1 0.047 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.047 0.039 -9999.0 0.0 -0.368 1.0 1.0 RHOA 0.033 0.013 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.035 0.009 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.009 0.077 0.119 1.0 -0.232 12.0 13.0 NME1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.034 0.154 -9999.0 0.0 -0.416 16.0 16.0 regulation of cell-cell adhesion -0.0 0.062 -9999.0 0.0 -0.256 1.0 1.0 WASF2 -0.004 0.047 -9999.0 0.0 -0.145 5.0 5.0 Rap1/GTP 0.015 0.089 -9999.0 0.0 -0.326 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.125 -9999.0 0.0 -0.288 16.0 16.0 CCND1 -0.013 0.095 -9999.0 0.0 -0.292 12.0 12.0 VAV2 -0.049 0.243 -9999.0 0.0 -0.685 15.0 15.0 RAP1/GDP 0.016 0.103 0.267 1.0 -0.312 2.0 3.0 adherens junction assembly -0.033 0.15 -9999.0 0.0 -0.403 16.0 16.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.047 -9999.0 0.0 -0.506 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.028 0.112 -9999.0 0.0 -0.279 15.0 15.0 E-cadherin/beta catenin -0.0 0.075 -9999.0 0.0 -0.335 7.0 7.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.026 0.143 -9999.0 0.0 -0.429 12.0 12.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.506 2.0 2.0 Rac1/GTP -0.068 0.163 -9999.0 0.0 -0.521 13.0 13.0 E-cadherin/beta catenin/alpha catenin 0.044 0.08 -9999.0 0.0 -0.313 6.0 6.0 ITGAE 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.025 0.16 -9999.0 0.0 -0.43 15.0 15.0