Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.137 0.272 -9999.0 0.0 -0.564 42.0 42.0 IHH -0.008 0.093 -9999.0 0.0 -0.272 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.044 0.144 -9999.0 0.0 -0.32 30.0 30.0 LRPAP1 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.044 0.143 0.318 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 -0.118 0.237 -9999.0 0.0 -0.513 28.0 28.0 SMO -0.131 0.242 -9999.0 0.0 -0.422 53.0 53.0 AKT1 -0.076 0.231 -9999.0 0.0 -0.698 15.0 15.0 ARRB2 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.023 0.03 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.129 0.238 -9999.0 0.0 -0.415 53.0 53.0 STIL -0.079 0.161 0.198 1.0 -0.299 47.0 48.0 DHH N/PTCH2 0.053 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.059 0.158 -9999.0 0.0 -0.304 43.0 43.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.506 2.0 2.0 DHH 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.253 0.451 -9999.0 0.0 -0.974 42.0 42.0 determination of left/right symmetry -0.129 0.238 -9999.0 0.0 -0.415 53.0 53.0 PIK3R1 0.01 0.091 -9999.0 0.0 -0.506 4.0 4.0 skeletal system development -0.249 0.444 -9999.0 0.0 -0.96 42.0 42.0 IHH N/Hhip -0.054 0.158 -9999.0 0.0 -0.408 22.0 22.0 DHH N/Hhip -0.024 0.14 -9999.0 0.0 -0.368 20.0 20.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.129 0.238 -9999.0 0.0 -0.415 53.0 53.0 pancreas development -0.058 0.179 -9999.0 0.0 -0.505 20.0 20.0 HHAT -0.006 0.145 -9999.0 0.0 -0.506 12.0 12.0 PI3K 0.005 0.071 -9999.0 0.0 -0.368 4.0 4.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.054 0.189 -9999.0 0.0 -0.506 22.0 22.0 somite specification -0.129 0.238 -9999.0 0.0 -0.415 53.0 53.0 SHH Np/Cholesterol/PTCH1 -0.08 0.163 -9999.0 0.0 -0.305 48.0 48.0 SHH Np/Cholesterol/PTCH2 0.008 0.09 -9999.0 0.0 -0.286 13.0 13.0 SHH Np/Cholesterol/Megalin 0.001 0.096 -9999.0 0.0 -0.293 14.0 14.0 SHH -0.014 0.108 -9999.0 0.0 -0.369 13.0 13.0 catabolic process -0.083 0.165 -9999.0 0.0 -0.34 43.0 43.0 SMO/Vitamin D3 -0.11 0.206 -9999.0 0.0 -0.385 46.0 46.0 SHH Np/Cholesterol/Hhip -0.046 0.134 -9999.0 0.0 -0.303 30.0 30.0 LRP2 0.023 0.056 -9999.0 0.0 -0.506 1.0 1.0 receptor-mediated endocytosis -0.107 0.2 -9999.0 0.0 -0.378 46.0 46.0 SHH Np/Cholesterol/BOC -0.0 0.086 -9999.0 0.0 -0.286 12.0 12.0 SHH Np/Cholesterol/CDO 0.006 0.091 -9999.0 0.0 -0.287 13.0 13.0 mesenchymal cell differentiation 0.046 0.133 0.302 30.0 -9999.0 0.0 30.0 mol:Vitamin D3 -0.078 0.166 0.208 2.0 -0.305 48.0 50.0 IHH N/PTCH2 0.02 0.064 -9999.0 0.0 -0.324 1.0 1.0 CDON 0.032 0.025 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.068 0.176 -9999.0 0.0 -0.342 43.0 43.0 Megalin/LRPAP1 0.037 0.048 -9999.0 0.0 -0.368 1.0 1.0 PTCH2 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.004 0.085 -9999.0 0.0 -0.283 13.0 13.0 PTCH1 -0.083 0.166 -9999.0 0.0 -0.341 43.0 43.0 HHIP -0.058 0.18 -9999.0 0.0 -0.506 20.0 20.0