Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.083 0.188 -9999.0 0.0 -0.399 135.0 135.0 IHH -0.002 0.048 -9999.0 0.0 -0.076 141.0 141.0 SHH Np/Cholesterol/GAS1 0.023 0.028 -9999.0 0.0 -0.098 16.0 16.0 LRPAP1 0.018 0.024 -9999.0 0.0 -0.122 15.0 15.0 dorsoventral neural tube patterning -0.022 0.028 0.097 16.0 -9999.0 0.0 16.0 SMO/beta Arrestin2 -0.01 0.106 -9999.0 0.0 -0.272 12.0 12.0 SMO -0.018 0.107 -9999.0 0.0 -0.3 9.0 9.0 AKT1 -0.017 0.112 -9999.0 0.0 -0.332 39.0 39.0 ARRB2 0.022 0.014 -9999.0 0.0 -0.122 5.0 5.0 BOC 0.011 0.039 -9999.0 0.0 -0.122 44.0 44.0 ADRBK1 0.023 0.001 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.018 0.106 -9999.0 0.0 -0.297 9.0 9.0 STIL -0.016 0.082 -9999.0 0.0 -0.148 135.0 135.0 DHH N/PTCH2 0.034 0.011 -9999.0 0.0 -0.149 1.0 1.0 DHH N/PTCH1 -0.019 0.099 -9999.0 0.0 -0.178 136.0 136.0 PIK3CA 0.02 0.017 -9999.0 0.0 -0.122 7.0 7.0 DHH 0.022 0.011 -9999.0 0.0 -0.122 3.0 3.0 PTHLH -0.072 0.179 -9999.0 0.0 -0.376 135.0 135.0 determination of left/right symmetry -0.018 0.106 -9999.0 0.0 -0.297 9.0 9.0 PIK3R1 0.015 0.031 -9999.0 0.0 -0.122 27.0 27.0 skeletal system development -0.072 0.178 -9999.0 0.0 -0.374 135.0 135.0 IHH N/Hhip 0.016 0.039 -9999.0 0.0 -0.098 27.0 27.0 DHH N/Hhip 0.029 0.024 -9999.0 0.0 -0.073 28.0 28.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.018 0.106 -9999.0 0.0 -0.297 9.0 9.0 pancreas development 0.017 0.029 -9999.0 0.0 -0.122 24.0 24.0 HHAT 0.022 0.011 -9999.0 0.0 -0.122 3.0 3.0 PI3K 0.007 0.065 -9999.0 0.0 -0.128 96.0 96.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.014 0.035 -9999.0 0.0 -0.122 35.0 35.0 somite specification -0.018 0.106 -9999.0 0.0 -0.297 9.0 9.0 SHH Np/Cholesterol/PTCH1 -0.013 0.087 -9999.0 0.0 -0.152 136.0 136.0 SHH Np/Cholesterol/PTCH2 0.03 0.012 -9999.0 0.0 -0.101 3.0 3.0 SHH Np/Cholesterol/Megalin 0.007 0.039 -9999.0 0.0 -0.098 20.0 20.0 SHH 0.022 0.011 -9999.0 0.0 -0.086 5.0 5.0 catabolic process -0.033 0.109 -9999.0 0.0 -0.21 135.0 135.0 SMO/Vitamin D3 -0.01 0.097 -9999.0 0.0 -0.169 135.0 135.0 SHH Np/Cholesterol/Hhip 0.027 0.019 -9999.0 0.0 -0.099 3.0 3.0 LRP2 -0.016 0.064 -9999.0 0.0 -0.122 148.0 148.0 receptor-mediated endocytosis -0.02 0.098 -9999.0 0.0 -0.206 58.0 58.0 SHH Np/Cholesterol/BOC 0.02 0.033 -9999.0 0.0 -0.103 23.0 23.0 SHH Np/Cholesterol/CDO 0.018 0.036 -9999.0 0.0 -0.098 36.0 36.0 mesenchymal cell differentiation -0.027 0.019 0.099 3.0 -9999.0 0.0 3.0 mol:Vitamin D3 -0.011 0.088 -9999.0 0.0 -0.152 136.0 136.0 IHH N/PTCH2 0.021 0.032 -9999.0 0.0 -0.131 4.0 4.0 CDON 0.013 0.035 -9999.0 0.0 -0.122 35.0 35.0 IHH N/PTCH1 -0.028 0.114 -9999.0 0.0 -0.212 135.0 135.0 Megalin/LRPAP1 -0.011 0.065 -9999.0 0.0 -0.152 55.0 55.0 PTCH2 0.023 0.009 -9999.0 0.0 -0.122 2.0 2.0 SHH Np/Cholesterol 0.018 0.009 -9999.0 0.0 -0.105 2.0 2.0 PTCH1 -0.033 0.109 -9999.0 0.0 -0.211 135.0 135.0 HHIP 0.017 0.029 -9999.0 0.0 -0.122 24.0 24.0