E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.04 0.146 -9999.0 0.0 -0.336 97.0 97.0 KLHL20 -0.015 0.1 0.2 13.0 -0.221 57.0 70.0 CYFIP2 0.038 0.011 -9999.0 0.0 0.0 45.0 45.0 Rac1/GDP -0.012 0.107 0.284 4.0 -0.248 50.0 54.0 ENAH -0.038 0.144 -9999.0 0.0 -0.334 95.0 95.0 AP1M1 0.036 0.015 -9999.0 0.0 0.0 78.0 78.0 RAP1B 0.038 0.013 -9999.0 0.0 0.0 57.0 57.0 RAP1A 0.039 0.01 -9999.0 0.0 0.0 35.0 35.0 CTNNB1 0.039 0.01 -9999.0 0.0 0.0 32.0 32.0 CDC42/GTP 0.002 0.08 0.158 4.0 -0.172 53.0 57.0 ABI1/Sra1/Nap1 -0.032 0.053 -9999.0 0.0 -0.156 60.0 60.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.068 0.068 -9999.0 0.0 -0.112 43.0 43.0 RAPGEF1 -0.037 0.13 0.28 3.0 -0.304 87.0 90.0 CTNND1 0.041 0.007 -9999.0 0.0 0.0 17.0 17.0 regulation of calcium-dependent cell-cell adhesion -0.03 0.155 -9999.0 0.0 -0.336 101.0 101.0 CRK -0.034 0.137 0.25 1.0 -0.324 86.0 87.0 E-cadherin/gamma catenin/alpha catenin 0.05 0.065 -9999.0 0.0 -0.136 42.0 42.0 alphaE/beta7 Integrin 0.05 0.038 -9999.0 0.0 -0.134 17.0 17.0 IQGAP1 0.037 0.014 -9999.0 0.0 0.0 67.0 67.0 NCKAP1 0.039 0.01 -9999.0 0.0 0.0 33.0 33.0 Rap1/GTP/I-afadin 0.042 0.065 -9999.0 0.0 -0.112 64.0 64.0 DLG1 -0.044 0.15 -9999.0 0.0 -0.339 102.0 102.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.034 0.048 -9999.0 0.0 -0.147 55.0 55.0 MLLT4 0.033 0.017 -9999.0 0.0 0.0 110.0 110.0 ARF6/GTP/NME1/Tiam1 0.046 0.062 -9999.0 0.0 -0.109 57.0 57.0 PI3K -0.04 0.063 -9999.0 0.0 -0.191 53.0 53.0 ARF6 0.04 0.007 -9999.0 0.0 0.0 18.0 18.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.038 0.052 -9999.0 0.0 -0.149 30.0 30.0 TIAM1 0.037 0.014 -9999.0 0.0 0.0 70.0 70.0 E-cadherin(dimer)/Ca2+ 0.063 0.072 -9999.0 0.0 -0.127 51.0 51.0 AKT1 -0.008 0.062 0.16 14.0 -0.158 18.0 32.0 PIK3R1 0.034 0.016 -9999.0 0.0 0.0 106.0 106.0 CDH1 0.035 0.016 -9999.0 0.0 0.0 96.0 96.0 RhoA/GDP -0.013 0.107 0.22 5.0 -0.247 53.0 58.0 actin cytoskeleton organization -0.009 0.076 0.163 14.0 -0.162 55.0 69.0 CDC42/GDP -0.012 0.107 0.28 4.0 -0.253 48.0 52.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.002 0.073 -9999.0 0.0 -0.193 55.0 55.0 ITGB7 0.039 0.011 -9999.0 0.0 0.0 39.0 39.0 RAC1 0.039 0.01 -9999.0 0.0 0.0 35.0 35.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.068 0.078 -9999.0 0.0 -0.136 51.0 51.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.046 0.056 -9999.0 0.0 -0.108 48.0 48.0 mol:GDP -0.031 0.111 0.278 4.0 -0.284 50.0 54.0 CDC42/GTP/IQGAP1 0.04 0.046 -9999.0 0.0 -0.114 40.0 40.0 JUP 0.037 0.014 -9999.0 0.0 0.0 67.0 67.0 p120 catenin/RhoA/GDP -0.001 0.115 0.234 4.0 -0.251 54.0 58.0 RAC1/GTP/IQGAP1 0.038 0.046 -9999.0 0.0 -0.113 40.0 40.0 PIP5K1C/AP1M1 0.048 0.027 -9999.0 0.0 -0.136 1.0 1.0 RHOA 0.041 0.007 -9999.0 0.0 0.0 14.0 14.0 CDC42 0.04 0.008 -9999.0 0.0 0.0 22.0 22.0 CTNNA1 0.039 0.01 -9999.0 0.0 0.0 36.0 36.0 positive regulation of S phase of mitotic cell cycle -0.015 0.059 0.125 4.0 -0.121 97.0 101.0 NME1 0.035 0.015 -9999.0 0.0 0.0 87.0 87.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.039 0.147 -9999.0 0.0 -0.343 93.0 93.0 regulation of cell-cell adhesion -0.009 0.065 -9999.0 0.0 -0.15 56.0 56.0 WASF2 -0.006 0.042 0.098 12.0 -0.091 49.0 61.0 Rap1/GTP 0.001 0.087 0.21 7.0 -0.215 34.0 41.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.072 0.082 -9999.0 0.0 -0.124 45.0 45.0 CCND1 -0.019 0.071 0.143 4.0 -0.147 97.0 101.0 VAV2 -0.047 0.211 -9999.0 0.0 -0.603 48.0 48.0 RAP1/GDP -0.0 0.098 0.252 5.0 -0.255 30.0 35.0 adherens junction assembly -0.039 0.143 -9999.0 0.0 -0.333 94.0 94.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.04 0.009 -9999.0 0.0 0.0 28.0 28.0 PIP5K1C 0.037 0.013 -9999.0 0.0 0.0 63.0 63.0 regulation of heterotypic cell-cell adhesion 0.046 0.076 0.219 6.0 -0.126 58.0 64.0 E-cadherin/beta catenin 0.007 0.04 0.146 1.0 -0.227 12.0 13.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.038 0.142 -9999.0 0.0 -0.332 94.0 94.0 PIK3CA 0.03 0.019 -9999.0 0.0 0.0 150.0 150.0 Rac1/GTP -0.054 0.13 -9999.0 0.0 -0.35 63.0 63.0 E-cadherin/beta catenin/alpha catenin 0.052 0.065 -9999.0 0.0 -0.13 48.0 48.0 ITGAE 0.039 0.01 -9999.0 0.0 0.0 34.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.031 0.158 -9999.0 0.0 -0.343 101.0 101.0