Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.065 0.175 -9999.0 0.0 -0.392 122.0 122.0 IHH 0.022 0.066 -9999.0 0.0 -0.099 125.0 125.0 SHH Np/Cholesterol/GAS1 0.028 0.025 -9999.0 0.0 -0.105 12.0 12.0 LRPAP1 0.036 0.015 -9999.0 0.0 0.0 79.0 79.0 dorsoventral neural tube patterning -0.028 0.025 0.105 12.0 -9999.0 0.0 12.0 SMO/beta Arrestin2 0.018 0.119 0.244 2.0 -0.201 106.0 108.0 SMO -0.003 0.108 -9999.0 0.0 -0.204 112.0 112.0 AKT1 -0.013 0.132 -9999.0 0.0 -0.395 35.0 35.0 ARRB2 0.039 0.01 -9999.0 0.0 0.0 37.0 37.0 BOC 0.035 0.015 -9999.0 0.0 0.0 86.0 86.0 ADRBK1 0.041 0.005 -9999.0 0.0 0.0 7.0 7.0 heart looping -0.002 0.108 0.191 3.0 -0.202 112.0 115.0 STIL -0.0 0.096 0.208 28.0 -0.171 104.0 132.0 DHH N/PTCH2 0.058 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.004 0.107 -9999.0 0.0 -0.189 125.0 125.0 PIK3CA 0.03 0.019 -9999.0 0.0 0.0 150.0 150.0 DHH 0.041 0.007 -9999.0 0.0 0.0 14.0 14.0 PTHLH -0.033 0.173 -9999.0 0.0 -0.377 106.0 106.0 determination of left/right symmetry -0.002 0.108 0.191 3.0 -0.202 112.0 115.0 PIK3R1 0.034 0.016 -9999.0 0.0 0.0 106.0 106.0 skeletal system development -0.032 0.172 -9999.0 0.0 -0.375 106.0 106.0 IHH N/Hhip 0.035 0.054 -9999.0 0.0 -0.06 117.0 117.0 DHH N/Hhip 0.054 0.022 -9999.0 0.0 -0.136 1.0 1.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.002 0.108 0.191 3.0 -0.202 112.0 115.0 pancreas development 0.038 0.013 -9999.0 0.0 0.0 55.0 55.0 HHAT 0.04 0.008 -9999.0 0.0 0.0 20.0 20.0 PI3K 0.024 0.062 -9999.0 0.0 -0.152 47.0 47.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.037 0.013 -9999.0 0.0 0.0 65.0 65.0 somite specification -0.002 0.108 0.191 3.0 -0.202 112.0 115.0 SHH Np/Cholesterol/PTCH1 -0.006 0.085 -9999.0 0.0 -0.171 108.0 108.0 SHH Np/Cholesterol/PTCH2 0.032 0.015 -9999.0 0.0 -0.105 1.0 1.0 SHH Np/Cholesterol/Megalin 0.021 0.028 -9999.0 0.0 -0.104 16.0 16.0 SHH -0.018 0.007 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.036 0.095 -9999.0 0.0 -0.21 126.0 126.0 SMO/Vitamin D3 -0.007 0.1 0.195 17.0 -0.198 107.0 124.0 SHH Np/Cholesterol/Hhip 0.031 0.017 -9999.0 0.0 -0.105 2.0 2.0 LRP2 0.03 0.019 -9999.0 0.0 0.0 162.0 162.0 receptor-mediated endocytosis 0.001 0.101 0.192 20.0 -0.184 104.0 124.0 SHH Np/Cholesterol/BOC 0.026 0.028 -9999.0 0.0 -0.105 17.0 17.0 SHH Np/Cholesterol/CDO 0.023 0.034 -9999.0 0.0 -0.105 28.0 28.0 mesenchymal cell differentiation -0.03 0.017 0.105 2.0 -9999.0 0.0 2.0 mol:Vitamin D3 -0.013 0.088 0.205 23.0 -0.172 108.0 131.0 IHH N/PTCH2 0.039 0.054 -9999.0 0.0 -0.059 116.0 116.0 CDON 0.035 0.016 -9999.0 0.0 0.0 91.0 91.0 IHH N/PTCH1 -0.02 0.106 -9999.0 0.0 -0.21 127.0 127.0 Megalin/LRPAP1 0.027 0.055 -9999.0 0.0 -0.139 40.0 40.0 PTCH2 0.04 0.009 -9999.0 0.0 0.0 26.0 26.0 SHH Np/Cholesterol 0.034 0.046 0.196 40.0 -0.098 1.0 41.0 PTCH1 -0.036 0.096 -9999.0 0.0 -0.21 126.0 126.0 HHIP 0.038 0.013 -9999.0 0.0 0.0 55.0 55.0