E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.037 0.173 -9999.0 0.0 -0.452 74.0 74.0 KLHL20 -0.015 0.1 -9999.0 0.0 -0.245 28.0 28.0 CYFIP2 -0.042 0.163 -9999.0 0.0 -0.464 65.0 65.0 Rac1/GDP 0.006 0.113 -9999.0 0.0 -0.314 16.0 16.0 ENAH -0.036 0.175 -9999.0 0.0 -0.448 76.0 76.0 AP1M1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 RAP1B 0.012 0.044 -9999.0 0.0 -0.324 8.0 8.0 RAP1A 0.011 0.062 -9999.0 0.0 -0.521 7.0 7.0 CTNNB1 0.001 0.09 -9999.0 0.0 -0.452 19.0 19.0 CDC42/GTP -0.033 0.07 -9999.0 0.0 -0.299 10.0 10.0 ABI1/Sra1/Nap1 -0.042 0.054 -9999.0 0.0 -0.167 40.0 40.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.006 0.115 -9999.0 0.0 -0.275 79.0 79.0 RAPGEF1 -0.015 0.151 -9999.0 0.0 -0.377 74.0 74.0 CTNND1 0.016 0.029 -9999.0 0.0 -0.346 3.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.039 0.174 -9999.0 0.0 -0.461 74.0 74.0 CRK -0.025 0.162 -9999.0 0.0 -0.414 74.0 74.0 E-cadherin/gamma catenin/alpha catenin -0.011 0.115 -9999.0 0.0 -0.309 65.0 65.0 alphaE/beta7 Integrin 0.023 0.038 -9999.0 0.0 -0.369 5.0 5.0 IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.015 0.031 -9999.0 0.0 -0.324 4.0 4.0 Rap1/GTP/I-afadin 0.014 0.074 -9999.0 0.0 -0.281 29.0 29.0 DLG1 -0.031 0.169 -9999.0 0.0 -0.442 74.0 74.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.055 -9999.0 0.0 -0.226 12.0 12.0 MLLT4 -0.006 0.106 -9999.0 0.0 -0.46 26.0 26.0 ARF6/GTP/NME1/Tiam1 0.023 0.053 -9999.0 0.0 -0.304 10.0 10.0 PI3K -0.036 0.07 -9999.0 0.0 -0.296 12.0 12.0 ARF6 0.016 0.033 -9999.0 0.0 -0.521 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.027 0.133 -9999.0 0.0 -0.374 64.0 64.0 TIAM1 0.006 0.073 -9999.0 0.0 -0.44 13.0 13.0 E-cadherin(dimer)/Ca2+ -0.005 0.106 -9999.0 0.0 -0.259 76.0 76.0 AKT1 -0.022 0.043 -9999.0 0.0 -0.183 11.0 11.0 PIK3R1 -0.009 0.109 -9999.0 0.0 -0.422 32.0 32.0 CDH1 -0.049 0.173 -9999.0 0.0 -0.48 71.0 71.0 RhoA/GDP 0.002 0.121 -9999.0 0.0 -0.376 15.0 15.0 actin cytoskeleton organization -0.009 0.075 -9999.0 0.0 -0.176 28.0 28.0 CDC42/GDP 0.007 0.113 -9999.0 0.0 -0.31 16.0 16.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.008 0.09 -9999.0 0.0 -0.24 66.0 66.0 ITGB7 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.005 0.114 -9999.0 0.0 -0.275 76.0 76.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.014 0.105 -9999.0 0.0 -0.266 75.0 75.0 mol:GDP -0.004 0.127 -9999.0 0.0 -0.298 74.0 74.0 CDC42/GTP/IQGAP1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.011 0.056 -9999.0 0.0 -0.422 8.0 8.0 p120 catenin/RhoA/GDP 0.002 0.122 -9999.0 0.0 -0.376 15.0 15.0 RAC1/GTP/IQGAP1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.023 0.035 -9999.0 0.0 -0.369 4.0 4.0 RHOA 0.005 0.08 -9999.0 0.0 -0.521 12.0 12.0 CDC42 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 positive regulation of S phase of mitotic cell cycle -0.028 0.095 -9999.0 0.0 -0.202 100.0 100.0 NME1 0.012 0.039 -9999.0 0.0 -0.258 11.0 11.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.033 0.172 -9999.0 0.0 -0.443 75.0 75.0 regulation of cell-cell adhesion -0.029 0.062 -9999.0 0.0 -0.261 10.0 10.0 WASF2 -0.021 0.031 -9999.0 0.0 -0.133 4.0 4.0 Rap1/GTP -0.038 0.08 -9999.0 0.0 -0.345 10.0 10.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.009 0.104 -9999.0 0.0 -0.249 70.0 70.0 CCND1 -0.036 0.116 -9999.0 0.0 -0.252 100.0 100.0 VAV2 -0.023 0.159 -9999.0 0.0 -0.404 74.0 74.0 RAP1/GDP 0.004 0.106 -9999.0 0.0 -0.357 9.0 9.0 adherens junction assembly -0.032 0.167 -9999.0 0.0 -0.429 75.0 75.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.016 0.021 -9999.0 0.0 -0.258 3.0 3.0 PIP5K1C 0.014 0.042 -9999.0 0.0 -0.455 4.0 4.0 regulation of heterotypic cell-cell adhesion 0.006 0.108 -9999.0 0.0 -0.371 5.0 5.0 E-cadherin/beta catenin -0.045 0.113 -9999.0 0.0 -0.338 66.0 66.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.033 0.17 -9999.0 0.0 -0.44 75.0 75.0 PIK3CA 0.016 0.029 -9999.0 0.0 -0.346 3.0 3.0 Rac1/GTP -0.079 0.123 -9999.0 0.0 -0.378 36.0 36.0 E-cadherin/beta catenin/alpha catenin -0.017 0.122 -9999.0 0.0 -0.312 75.0 75.0 ITGAE 0.013 0.052 -9999.0 0.0 -0.521 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.04 0.178 -9999.0 0.0 -0.471 74.0 74.0