Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.01 0.068 0.392 10.0 -9999.0 0.0 10.0 KIRREL 0.009 0.071 -9999.0 0.0 -0.53 9.0 9.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.01 0.068 -9999.0 0.0 -0.393 10.0 10.0 PLCG1 0.016 0.026 -9999.0 0.0 -0.39 2.0 2.0 ARRB2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.01 0.066 -9999.0 0.0 -0.521 8.0 8.0 Nephrin/NEPH1/podocin/CD2AP 0.029 0.058 -9999.0 0.0 -0.275 13.0 13.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.025 0.06 -9999.0 0.0 -0.252 13.0 13.0 FYN 0.015 0.057 -9999.0 0.0 -0.253 18.0 18.0 mol:Ca2+ 0.028 0.059 -9999.0 0.0 -0.296 12.0 12.0 mol:DAG 0.028 0.059 -9999.0 0.0 -0.297 12.0 12.0 NPHS2 0.015 0.036 -9999.0 0.0 -0.432 3.0 3.0 mol:IP3 0.028 0.059 -9999.0 0.0 -0.297 12.0 12.0 regulation of endocytosis 0.028 0.056 -9999.0 0.0 -0.255 12.0 12.0 Nephrin/NEPH1/podocin/Cholesterol 0.019 0.054 -9999.0 0.0 -0.282 12.0 12.0 establishment of cell polarity 0.01 0.068 -9999.0 0.0 -0.392 10.0 10.0 Nephrin/NEPH1/podocin/NCK1-2 0.035 0.059 -9999.0 0.0 -0.253 13.0 13.0 Nephrin/NEPH1/beta Arrestin2 0.03 0.057 -9999.0 0.0 -0.258 12.0 12.0 NPHS1 0.004 0.062 -9999.0 0.0 -0.267 25.0 25.0 Nephrin/NEPH1/podocin 0.021 0.059 -9999.0 0.0 -0.254 18.0 18.0 TJP1 0.013 0.052 -9999.0 0.0 -0.521 5.0 5.0 NCK1 0.011 0.046 -9999.0 0.0 -0.28 12.0 12.0 NCK2 0.015 0.027 -9999.0 0.0 -0.258 5.0 5.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.029 0.06 -9999.0 0.0 -0.298 12.0 12.0 CD2AP 0.016 0.029 -9999.0 0.0 -0.346 3.0 3.0 Nephrin/NEPH1/podocin/GRB2 0.029 0.056 -9999.0 0.0 -0.274 12.0 12.0 GRB2 0.016 0.024 -9999.0 0.0 -0.258 4.0 4.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.012 0.067 -9999.0 0.0 -0.267 23.0 23.0 cytoskeleton organization 0.03 0.062 -9999.0 0.0 -0.275 13.0 13.0 Nephrin/NEPH1 0.011 0.048 -9999.0 0.0 -0.276 10.0 10.0 Nephrin/NEPH1/ZO-1 0.019 0.064 -9999.0 0.0 -0.312 15.0 15.0