Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.099 0.254 -9999.0 0.0 -0.62 80.0 80.0 IHH -0.013 0.093 -9999.0 0.0 -0.483 14.0 14.0 SHH Np/Cholesterol/GAS1 -0.057 0.141 -9999.0 0.0 -0.29 133.0 133.0 LRPAP1 0.016 0.026 -9999.0 0.0 -0.39 2.0 2.0 dorsoventral neural tube patterning 0.056 0.14 0.288 133.0 -9999.0 0.0 133.0 SMO/beta Arrestin2 -0.053 0.169 -9999.0 0.0 -0.467 47.0 47.0 SMO -0.064 0.177 -9999.0 0.0 -0.464 58.0 58.0 AKT1 -0.027 0.134 -9999.0 0.0 -0.515 21.0 21.0 ARRB2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.018 0.12 -9999.0 0.0 -0.379 48.0 48.0 ADRBK1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.063 0.175 -9999.0 0.0 -0.458 58.0 58.0 STIL -0.052 0.148 -9999.0 0.0 -0.364 56.0 56.0 DHH N/PTCH2 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.027 0.126 -9999.0 0.0 -0.369 23.0 23.0 PIK3CA 0.016 0.029 -9999.0 0.0 -0.346 3.0 3.0 DHH 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.119 0.308 -9999.0 0.0 -0.755 79.0 79.0 determination of left/right symmetry -0.063 0.175 -9999.0 0.0 -0.458 58.0 58.0 PIK3R1 -0.009 0.109 -9999.0 0.0 -0.422 32.0 32.0 skeletal system development -0.117 0.304 -9999.0 0.0 -0.746 79.0 79.0 IHH N/Hhip 0.004 0.069 -9999.0 0.0 -0.291 22.0 22.0 DHH N/Hhip 0.021 0.037 -9999.0 0.0 -0.369 3.0 3.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.063 0.175 -9999.0 0.0 -0.458 58.0 58.0 pancreas development 0.01 0.052 -9999.0 0.0 -0.329 11.0 11.0 HHAT -0.045 0.172 -9999.0 0.0 -0.509 63.0 63.0 PI3K 0.006 0.082 -9999.0 0.0 -0.369 21.0 21.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.072 0.194 -9999.0 0.0 -0.467 98.0 98.0 somite specification -0.063 0.175 -9999.0 0.0 -0.458 58.0 58.0 SHH Np/Cholesterol/PTCH1 -0.048 0.143 -9999.0 0.0 -0.359 48.0 48.0 SHH Np/Cholesterol/PTCH2 -0.007 0.098 -9999.0 0.0 -0.275 61.0 61.0 SHH Np/Cholesterol/Megalin -0.102 0.182 -9999.0 0.0 -0.333 181.0 181.0 SHH -0.021 0.126 -9999.0 0.0 -0.369 61.0 61.0 catabolic process -0.042 0.141 -9999.0 0.0 -0.33 74.0 74.0 SMO/Vitamin D3 -0.06 0.165 -9999.0 0.0 -0.398 64.0 64.0 SHH Np/Cholesterol/Hhip -0.01 0.101 -9999.0 0.0 -0.277 64.0 64.0 LRP2 -0.156 0.245 -9999.0 0.0 -0.484 183.0 183.0 receptor-mediated endocytosis -0.119 0.197 -9999.0 0.0 -0.449 97.0 97.0 SHH Np/Cholesterol/BOC -0.026 0.115 -9999.0 0.0 -0.283 83.0 83.0 SHH Np/Cholesterol/CDO -0.019 0.112 -9999.0 0.0 -0.287 74.0 74.0 mesenchymal cell differentiation 0.011 0.1 0.276 64.0 -9999.0 0.0 64.0 mol:Vitamin D3 -0.046 0.145 -9999.0 0.0 -0.36 48.0 48.0 IHH N/PTCH2 0.01 0.055 -9999.0 0.0 -0.322 11.0 11.0 CDON -0.004 0.099 -9999.0 0.0 -0.414 27.0 27.0 IHH N/PTCH1 -0.04 0.144 -9999.0 0.0 -0.332 74.0 74.0 Megalin/LRPAP1 -0.101 0.181 -9999.0 0.0 -0.371 158.0 158.0 PTCH2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.017 0.097 -9999.0 0.0 -0.284 61.0 61.0 PTCH1 -0.042 0.142 -9999.0 0.0 -0.331 74.0 74.0 HHIP 0.01 0.052 -9999.0 0.0 -0.33 11.0 11.0