E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.069 0.164 -9999.0 0.0 -0.412 64.0 64.0 KLHL20 -0.025 0.09 0.247 1.0 -0.259 16.0 17.0 CYFIP2 -0.006 0.128 -9999.0 0.0 -0.421 44.0 44.0 Rac1/GDP -0.033 0.119 0.265 5.0 -0.265 60.0 65.0 ENAH -0.064 0.161 -9999.0 0.0 -0.414 62.0 62.0 AP1M1 0.034 0.021 -9999.0 0.0 -0.421 1.0 1.0 RAP1B 0.032 0.03 -9999.0 0.0 -0.421 2.0 2.0 RAP1A 0.03 0.05 -9999.0 0.0 -0.421 6.0 6.0 CTNNB1 0.024 0.067 -9999.0 0.0 -0.421 11.0 11.0 CDC42/GTP -0.012 0.083 -9999.0 0.0 -0.253 7.0 7.0 ABI1/Sra1/Nap1 -0.046 0.054 -9999.0 0.0 -0.162 36.0 36.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.03 0.104 -9999.0 0.0 -0.234 58.0 58.0 RAPGEF1 -0.07 0.154 0.236 2.0 -0.367 77.0 79.0 CTNND1 0.033 0.022 -9999.0 0.0 -0.421 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.073 0.182 -9999.0 0.0 -0.414 83.0 83.0 CRK -0.067 0.162 -9999.0 0.0 -0.389 79.0 79.0 E-cadherin/gamma catenin/alpha catenin 0.019 0.098 -9999.0 0.0 -0.261 48.0 48.0 alphaE/beta7 Integrin 0.044 0.038 -9999.0 0.0 -0.301 5.0 5.0 IQGAP1 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.021 -9999.0 0.0 -0.421 1.0 1.0 Rap1/GTP/I-afadin 0.047 0.063 -9999.0 0.0 -0.23 21.0 21.0 DLG1 -0.081 0.176 -9999.0 0.0 -0.404 85.0 85.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.03 0.056 -9999.0 0.0 -0.179 16.0 16.0 MLLT4 0.02 0.075 -9999.0 0.0 -0.421 14.0 14.0 ARF6/GTP/NME1/Tiam1 0.056 0.045 -9999.0 0.0 -0.235 9.0 9.0 PI3K -0.035 0.074 -9999.0 0.0 -0.229 16.0 16.0 ARF6 0.033 0.029 -9999.0 0.0 -0.421 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.004 0.104 -9999.0 0.0 -0.306 48.0 48.0 TIAM1 0.028 0.057 -9999.0 0.0 -0.421 8.0 8.0 E-cadherin(dimer)/Ca2+ 0.03 0.096 -9999.0 0.0 -0.219 56.0 56.0 AKT1 -0.024 0.053 0.176 4.0 -0.168 6.0 10.0 PIK3R1 0.018 0.082 -9999.0 0.0 -0.421 17.0 17.0 CDH1 -0.012 0.129 -9999.0 0.0 -0.421 45.0 45.0 RhoA/GDP -0.033 0.122 0.264 5.0 -0.272 60.0 65.0 actin cytoskeleton organization -0.017 0.068 0.173 2.0 -0.192 14.0 16.0 CDC42/GDP -0.031 0.118 0.264 5.0 -0.264 59.0 64.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.01 0.077 -9999.0 0.0 -0.217 55.0 55.0 ITGB7 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.033 0.103 -9999.0 0.0 -0.234 56.0 56.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.018 0.087 -9999.0 0.0 -0.216 55.0 55.0 mol:GDP -0.052 0.124 0.264 5.0 -0.3 62.0 67.0 CDC42/GTP/IQGAP1 0.045 0.013 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.028 0.042 -9999.0 0.0 -0.421 4.0 4.0 p120 catenin/RhoA/GDP -0.029 0.129 0.275 4.0 -0.28 60.0 64.0 RAC1/GTP/IQGAP1 0.045 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.048 0.033 -9999.0 0.0 -0.301 4.0 4.0 RHOA 0.026 0.061 -9999.0 0.0 -0.421 9.0 9.0 CDC42 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.03 0.077 0.141 2.0 -0.186 80.0 82.0 NME1 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.078 0.174 -9999.0 0.0 -0.408 81.0 81.0 regulation of cell-cell adhesion -0.018 0.069 -9999.0 0.0 -0.201 13.0 13.0 WASF2 -0.016 0.041 0.109 3.0 -0.114 9.0 12.0 Rap1/GTP -0.014 0.093 0.246 2.0 -0.275 8.0 10.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.037 0.103 -9999.0 0.0 -0.228 52.0 52.0 CCND1 -0.038 0.095 0.161 2.0 -0.23 80.0 82.0 VAV2 -0.066 0.187 -9999.0 0.0 -0.579 13.0 13.0 RAP1/GDP -0.018 0.103 0.267 2.0 -0.27 13.0 15.0 adherens junction assembly -0.077 0.17 -9999.0 0.0 -0.395 82.0 82.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.032 0.036 -9999.0 0.0 -0.421 3.0 3.0 regulation of heterotypic cell-cell adhesion 0.028 0.105 -9999.0 0.0 -0.22 61.0 61.0 E-cadherin/beta catenin -0.024 0.102 -9999.0 0.0 -0.287 63.0 63.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.079 0.174 -9999.0 0.0 -0.405 84.0 84.0 PIK3CA 0.033 0.022 -9999.0 0.0 -0.421 1.0 1.0 Rac1/GTP -0.076 0.13 -9999.0 0.0 -0.398 28.0 28.0 E-cadherin/beta catenin/alpha catenin 0.02 0.102 -9999.0 0.0 -0.255 55.0 55.0 ITGAE 0.028 0.046 -9999.0 0.0 -0.421 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.074 0.186 -9999.0 0.0 -0.423 83.0 83.0