Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.039 0.048 0.306 6.0 -9999.0 0.0 6.0 KIRREL 0.026 0.053 -9999.0 0.0 -0.427 6.0 6.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.039 0.048 -9999.0 0.0 -0.307 6.0 6.0 PLCG1 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.029 0.054 -9999.0 0.0 -0.421 7.0 7.0 Nephrin/NEPH1/podocin/CD2AP 0.064 0.057 -9999.0 0.0 -0.238 6.0 6.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.022 0.044 -9999.0 0.0 -0.211 12.0 12.0 FYN 0.058 0.101 0.279 69.0 -0.21 11.0 80.0 mol:Ca2+ 0.058 0.056 -9999.0 0.0 -0.236 6.0 6.0 mol:DAG 0.059 0.057 -9999.0 0.0 -0.237 6.0 6.0 NPHS2 0.03 0.029 -9999.0 0.0 -0.429 1.0 1.0 mol:IP3 0.059 0.057 -9999.0 0.0 -0.237 6.0 6.0 regulation of endocytosis 0.046 0.054 -9999.0 0.0 -0.204 10.0 10.0 Nephrin/NEPH1/podocin/Cholesterol 0.049 0.048 -9999.0 0.0 -0.234 6.0 6.0 establishment of cell polarity 0.039 0.048 -9999.0 0.0 -0.306 6.0 6.0 Nephrin/NEPH1/podocin/NCK1-2 0.076 0.064 -9999.0 0.0 -0.222 7.0 7.0 Nephrin/NEPH1/beta Arrestin2 0.051 0.057 -9999.0 0.0 -0.207 10.0 10.0 NPHS1 0.041 0.03 -9999.0 0.0 -0.386 1.0 1.0 Nephrin/NEPH1/podocin 0.048 0.055 0.202 12.0 -0.211 11.0 23.0 TJP1 0.031 0.036 -9999.0 0.0 -0.421 3.0 3.0 NCK1 0.034 0.021 -9999.0 0.0 -0.421 1.0 1.0 NCK2 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.06 0.057 -9999.0 0.0 -0.238 6.0 6.0 CD2AP 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.06 0.057 -9999.0 0.0 -0.238 6.0 6.0 GRB2 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.057 0.105 0.286 69.0 -0.228 11.0 80.0 cytoskeleton organization 0.023 0.067 0.232 30.0 -0.252 6.0 36.0 Nephrin/NEPH1 0.033 0.036 -9999.0 0.0 -0.209 6.0 6.0 Nephrin/NEPH1/ZO-1 0.05 0.054 -9999.0 0.0 -0.252 9.0 9.0