Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.013 0.082 -9999.0 0.0 -0.215 66.0 66.0 epithelial cell differentiation 0.026 0.093 -9999.0 0.0 -0.217 56.0 56.0 CYFIP2 -0.006 0.128 -9999.0 0.0 -0.421 44.0 44.0 ENAH -0.027 0.077 0.371 2.0 -0.308 8.0 10.0 EGFR -0.013 0.131 -9999.0 0.0 -0.421 47.0 47.0 EPHA2 0.031 0.036 -9999.0 0.0 -0.421 3.0 3.0 MYO6 -0.037 0.077 0.181 7.0 -0.218 67.0 74.0 CTNNB1 0.024 0.067 -9999.0 0.0 -0.421 11.0 11.0 ABI1/Sra1/Nap1 0.041 0.089 -9999.0 0.0 -0.256 39.0 39.0 AQP5 -0.094 0.17 -9999.0 0.0 -0.451 83.0 83.0 CTNND1 0.033 0.022 -9999.0 0.0 -0.421 1.0 1.0 mol:PI-4-5-P2 -0.031 0.069 0.179 6.0 -0.212 57.0 63.0 regulation of calcium-dependent cell-cell adhesion -0.032 0.068 0.179 5.0 -0.208 58.0 63.0 EGF -0.069 0.186 -9999.0 0.0 -0.421 110.0 110.0 NCKAP1 0.034 0.021 -9999.0 0.0 -0.421 1.0 1.0 AQP3 -0.095 0.173 -9999.0 0.0 -0.453 84.0 84.0 cortical microtubule organization 0.026 0.093 -9999.0 0.0 -0.217 56.0 56.0 GO:0000145 -0.033 0.064 0.162 6.0 -0.203 57.0 63.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.03 0.096 -9999.0 0.0 -0.219 56.0 56.0 MLLT4 0.02 0.075 -9999.0 0.0 -0.421 14.0 14.0 ARF6/GDP -0.041 0.068 -9999.0 0.0 -0.273 16.0 16.0 ARF6 0.033 0.029 -9999.0 0.0 -0.421 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.053 0.071 -9999.0 0.0 -0.234 20.0 20.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.026 0.093 -9999.0 0.0 -0.335 18.0 18.0 PVRL2 0.026 0.064 -9999.0 0.0 -0.421 10.0 10.0 ZYX -0.033 0.074 0.181 8.0 -0.215 63.0 71.0 ARF6/GTP 0.058 0.077 -9999.0 0.0 -0.239 20.0 20.0 CDH1 -0.012 0.129 -9999.0 0.0 -0.421 45.0 45.0 EGFR/EGFR/EGF/EGF -0.057 0.137 -9999.0 0.0 -0.223 190.0 190.0 RhoA/GDP 0.023 0.098 -9999.0 0.0 -0.216 63.0 63.0 actin cytoskeleton organization -0.04 0.074 0.165 7.0 -0.219 54.0 61.0 IGF-1R heterotetramer -0.043 0.169 -9999.0 0.0 -0.421 84.0 84.0 GIT1 0.033 0.022 -9999.0 0.0 -0.421 1.0 1.0 IGF1R -0.043 0.169 -9999.0 0.0 -0.421 84.0 84.0 IGF1 -0.041 0.166 -9999.0 0.0 -0.421 81.0 81.0 DIAPH1 0.002 0.202 -9999.0 0.0 -0.571 45.0 45.0 Wnt receptor signaling pathway -0.026 0.093 0.217 56.0 -9999.0 0.0 56.0 RHOA 0.026 0.061 -9999.0 0.0 -0.421 9.0 9.0 RhoA/GTP -0.043 0.068 -9999.0 0.0 -0.221 58.0 58.0 CTNNA1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.041 0.075 0.166 7.0 -0.223 54.0 61.0 EFNA1 0.014 0.08 -9999.0 0.0 -0.421 16.0 16.0 LPP -0.038 0.071 0.17 8.0 -0.208 64.0 72.0 Ephrin A1/EPHA2 0.009 0.092 -9999.0 0.0 -0.222 57.0 57.0 SEC6/SEC8 -0.048 0.068 -9999.0 0.0 -0.209 70.0 70.0 MGAT3 -0.032 0.069 0.181 5.0 -0.211 58.0 63.0 HGF/MET 0.015 0.093 -9999.0 0.0 -0.207 66.0 66.0 HGF 0.028 0.057 -9999.0 0.0 -0.421 8.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.013 0.083 -9999.0 0.0 -0.217 66.0 66.0 actin cable formation 0.015 0.108 0.233 28.0 -0.292 10.0 38.0 KIAA1543 -0.037 0.068 0.169 7.0 -0.213 57.0 64.0 KIFC3 -0.031 0.067 0.181 6.0 -0.21 56.0 62.0 NCK1 0.034 0.021 -9999.0 0.0 -0.421 1.0 1.0 EXOC3 0.036 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.034 0.074 0.181 8.0 -0.214 64.0 72.0 NCK1/GIT1 0.048 0.025 -9999.0 0.0 -0.296 2.0 2.0 mol:GDP 0.026 0.093 -9999.0 0.0 -0.217 56.0 56.0 EXOC4 0.034 0.021 -9999.0 0.0 -0.421 1.0 1.0 STX4 -0.033 0.062 -9999.0 0.0 -0.208 56.0 56.0 PIP5K1C -0.032 0.07 0.181 6.0 -0.215 57.0 63.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.008 0.104 0.335 5.0 -0.325 7.0 12.0 adherens junction assembly -0.045 0.115 0.265 1.0 -0.477 15.0 16.0 IGF-1R heterotetramer/IGF1 -0.057 0.148 -9999.0 0.0 -0.244 177.0 177.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.074 -9999.0 0.0 -0.3 23.0 23.0 MET 0.028 0.046 -9999.0 0.0 -0.421 5.0 5.0 PLEKHA7 -0.03 0.07 0.181 8.0 -0.211 56.0 64.0 mol:GTP 0.05 0.07 -9999.0 0.0 -0.233 20.0 20.0 establishment of epithelial cell apical/basal polarity -0.043 0.072 0.14 14.0 -0.29 4.0 18.0 cortical actin cytoskeleton stabilization -0.013 0.082 -9999.0 0.0 -0.215 66.0 66.0 regulation of cell-cell adhesion -0.04 0.074 0.165 7.0 -0.219 54.0 61.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.013 0.083 -9999.0 0.0 -0.217 66.0 66.0