rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p	q
1	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(187), APC2(1), AXIN1(2), AXIN2(9), BTRC(5), CACYBP(2), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CCND2(1), CCND3(1), CER1(3), CHD8(6), CREBBP(25), CSNK1A1(2), CSNK1A1L(5), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTBP1(1), CTBP2(2), CTNNB1(12), CTNNBIP1(1), CUL1(8), CXXC4(1), DAAM1(2), DAAM2(9), DKK1(5), DKK2(6), DKK4(7), DVL2(9), DVL3(4), EP300(15), FBXW11(8), FZD1(1), FZD10(6), FZD2(2), FZD3(13), FZD4(2), FZD6(6), FZD7(3), FZD8(1), GSK3B(8), LEF1(4), LRP5(5), LRP6(17), MAP3K7(4), MAPK10(8), MAPK8(7), MAPK9(5), MMP7(5), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NKD1(3), NKD2(1), NLK(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PORCN(2), PPARD(2), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(2), PPP2R2A(1), PPP2R2B(3), PPP2R2C(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRICKLE1(11), PRICKLE2(6), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), PSEN1(3), RBX1(1), RHOA(5), ROCK1(15), ROCK2(6), RUVBL1(8), SENP2(3), SFRP1(3), SFRP2(3), SFRP4(4), SFRP5(1), SIAH1(1), SKP1(1), SMAD2(16), SMAD3(9), SMAD4(29), SOX17(2), TBL1X(6), TBL1XR1(6), TBL1Y(1), TCF7(6), TCF7L1(3), TCF7L2(20), TP53(122), VANGL1(2), VANGL2(5), WIF1(2), WNT1(1), WNT10B(4), WNT11(3), WNT16(2), WNT2(1), WNT2B(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2)	54356112	894	218	758	155	275	204	133	8	221	53	<1.00e-15	<1.10e-14
2	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(1), ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), APC(187), APC2(1), ARAF(3), ARHGEF1(5), ARHGEF12(9), ARHGEF4(4), ARHGEF6(10), ARHGEF7(8), ARPC1A(5), ARPC1B(2), ARPC2(2), ARPC5(1), ARPC5L(2), BAIAP2(1), BDKRB2(3), BRAF(23), CD14(1), CDC42(1), CFL1(1), CHRM1(3), CHRM2(11), CHRM3(4), CHRM4(1), CHRM5(2), CRKL(2), CSK(3), CYFIP1(6), CYFIP2(5), DIAPH1(1), DIAPH2(12), DIAPH3(5), DOCK1(7), EGF(3), EGFR(11), EZR(2), F2(3), FGD1(8), FGD3(2), FGF1(2), FGF11(3), FGF12(3), FGF13(3), FGF14(5), FGF17(1), FGF19(1), FGF20(2), FGF21(1), FGF23(1), FGF3(1), FGF5(4), FGF6(3), FGF7(1), FGF8(1), FGF9(1), FGFR1(4), FGFR2(6), FGFR3(2), FGFR4(2), FN1(21), GIT1(3), GNA12(2), GNA13(2), GRLF1(12), IQGAP1(13), IQGAP2(12), IQGAP3(11), ITGA1(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGAD(8), ITGAE(7), ITGAL(8), ITGAM(8), ITGAV(5), ITGAX(6), ITGB1(6), ITGB2(5), ITGB3(9), ITGB4(3), ITGB5(6), ITGB6(6), ITGB7(4), ITGB8(5), KRAS(96), LIMK1(5), LIMK2(5), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MOS(3), MRAS(1), MSN(6), MYH10(10), MYH14(12), MYH9(12), MYL2(1), MYL7(1), MYL9(2), MYLK(14), MYLK2(3), NCKAP1(9), NCKAP1L(11), NRAS(20), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PDGFA(1), PDGFRA(17), PDGFRB(6), PFN2(1), PFN4(1), PIK3CA(40), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(4), PPP1CB(2), PPP1CC(2), PPP1R12A(3), PPP1R12B(9), PTK2(5), RAF1(6), RDX(3), RHOA(5), ROCK1(15), ROCK2(6), RRAS2(2), SCIN(3), SLC9A1(4), SOS1(7), SOS2(11), SSH1(6), SSH2(4), SSH3(1), TIAM1(17), TIAM2(16), TMSL3(1), VAV1(13), VAV2(4), VAV3(12), VCL(2), WAS(1), WASF1(3), WASF2(2), WASL(7)	94731820	1187	216	982	278	334	392	203	8	194	56	<1.00e-15	<1.10e-14
3	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(15), ACVR1C(3), AKT1(2), AKT2(6), AKT3(1), ARRB1(1), ATF2(1), ATF4(1), BDNF(1), BRAF(23), CACNA1A(17), CACNA1B(11), CACNA1C(12), CACNA1D(8), CACNA1E(21), CACNA1F(14), CACNA1G(10), CACNA1H(2), CACNA1I(5), CACNA1S(14), CACNA2D1(11), CACNA2D2(1), CACNA2D3(6), CACNA2D4(3), CACNB1(1), CACNB2(6), CACNB3(2), CACNB4(2), CACNG1(2), CACNG2(3), CACNG3(8), CACNG4(2), CACNG5(5), CACNG6(1), CACNG7(6), CACNG8(1), CASP3(2), CD14(1), CDC25B(5), CDC42(1), CHUK(6), CRKL(2), DAXX(1), DUSP1(2), DUSP10(5), DUSP16(5), DUSP3(1), DUSP4(1), DUSP5(2), DUSP6(5), DUSP7(2), DUSP9(1), ECSIT(3), EGF(3), EGFR(11), ELK4(2), FAS(2), FASLG(1), FGF1(2), FGF11(3), FGF12(3), FGF13(3), FGF14(5), FGF17(1), FGF19(1), FGF20(2), FGF21(1), FGF23(1), FGF3(1), FGF5(4), FGF6(3), FGF7(1), FGF8(1), FGF9(1), FGFR1(4), FGFR2(6), FGFR3(2), FGFR4(2), FLNA(3), FLNB(16), FLNC(13), FOS(1), GNA12(2), GRB2(3), IKBKB(4), IL1A(1), IL1B(1), IL1R1(4), IL1R2(7), KRAS(96), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K4(11), MAP2K5(4), MAP2K6(3), MAP3K1(8), MAP3K10(3), MAP3K12(6), MAP3K13(9), MAP3K14(3), MAP3K2(3), MAP3K3(3), MAP3K4(18), MAP3K5(6), MAP3K6(6), MAP3K7(4), MAP3K8(2), MAP4K1(3), MAP4K2(1), MAP4K3(4), MAP4K4(8), MAPK1(2), MAPK10(8), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK7(3), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(1), MAPT(5), MAX(1), MEF2C(9), MKNK1(1), MKNK2(3), MOS(3), MRAS(1), NF1(9), NFATC2(5), NFATC4(5), NFKB1(6), NFKB2(4), NLK(1), NR4A1(2), NRAS(20), NTF3(1), NTRK1(6), NTRK2(4), PAK1(5), PAK2(3), PDGFA(1), PDGFRA(17), PDGFRB(6), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PPM1A(7), PPM1B(2), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PPP5C(3), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), PTPN5(1), PTPN7(2), PTPRR(5), RAF1(6), RAP1A(2), RAP1B(2), RAPGEF2(13), RASA1(9), RASA2(3), RASGRF1(12), RASGRF2(9), RASGRP1(5), RASGRP2(7), RASGRP3(7), RASGRP4(2), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA5(6), RPS6KA6(7), RRAS2(2), SOS1(7), SOS2(11), SRF(3), STK3(3), STK4(3), STMN1(2), TAOK1(5), TAOK2(3), TAOK3(4), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7), TNFRSF1A(1), TP53(122), TRAF2(1), TRAF6(4), ZAK(6)	98648272	1145	213	961	310	405	372	215	10	137	6	<1.00e-15	<1.10e-14
4	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(187), AXIN1(2), CCND2(1), CCND3(1), CTNNB1(12), DVL2(9), DVL3(4), FBXW2(3), FZD1(1), FZD10(6), FZD2(2), FZD3(13), FZD6(6), FZD7(3), FZD8(1), GSK3B(8), LDLR(5), MAPK10(8), MAPK9(5), PAFAH1B1(3), PLAU(3), PPP2R5C(3), PPP2R5E(2), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCI(4), PRKCQ(5), PRKD1(15), RHOA(5), SFRP4(4), TCF7(6), WNT1(1), WNT10B(4), WNT11(3), WNT16(2), WNT2(1), WNT2B(3), WNT3(4), WNT4(1), WNT5A(3), WNT6(1), WNT7A(2), WNT7B(2)	19830148	380	187	317	61	83	73	42	2	128	52	<1.00e-15	<1.10e-14
5	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(2), APC(187), AXIN1(2), CD14(1), CTNNB1(12), FZD1(1), GJA1(7), GNAI1(4), GSK3B(8), IRAK1(1), LBP(1), LEF1(4), LY96(2), MYD88(2), NFKB1(6), PDPK1(1), PIK3CA(40), PIK3R1(10), PPP2CA(1), RELA(2), TIRAP(1), TLR4(10), TOLLIP(1), WNT1(1)	10111476	307	183	228	28	44	50	43	1	115	54	<1.00e-15	<1.10e-14
6	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(4), ABLIM1(6), ABLIM2(4), ABLIM3(5), ARHGEF12(9), CDC42(1), CFL1(1), CXCL12(1), CXCR4(4), DCC(16), DPYSL2(5), DPYSL5(1), EFNA3(1), EFNA4(1), EFNA5(5), EFNB1(3), EFNB2(1), EFNB3(3), EPHA1(6), EPHA2(5), EPHA3(17), EPHA4(6), EPHA5(17), EPHA6(5), EPHA7(10), EPHA8(7), EPHB1(9), EPHB2(8), EPHB3(2), EPHB4(5), EPHB6(4), FYN(5), GNAI1(4), GSK3B(8), ITGB1(6), KRAS(96), L1CAM(4), LIMK1(5), LIMK2(5), LRRC4C(8), MAPK1(2), MAPK3(3), MET(5), NCK1(1), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NGEF(1), NRAS(20), NRP1(1), NTN1(5), NTN4(6), NTNG1(4), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PLXNA1(2), PLXNA2(8), PLXNA3(2), PLXNB1(5), PLXNB2(2), PLXNB3(3), PLXNC1(9), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PTK2(5), RASA1(9), RGS3(10), RHOA(5), RND1(1), ROBO1(24), ROBO2(18), ROBO3(5), ROCK1(15), ROCK2(6), SEMA3A(9), SEMA3B(1), SEMA3C(3), SEMA3D(13), SEMA3E(9), SEMA3F(1), SEMA3G(4), SEMA4A(3), SEMA4B(2), SEMA4D(13), SEMA4F(9), SEMA4G(6), SEMA5A(8), SEMA5B(11), SEMA6A(2), SEMA6B(2), SEMA6C(3), SEMA6D(9), SEMA7A(2), SLIT1(11), SLIT2(15), SLIT3(9), SRGAP1(9), SRGAP2(3), SRGAP3(4), UNC5A(2), UNC5B(6), UNC5C(12), UNC5D(9)	66363964	737	183	630	196	250	285	115	7	80	0	<1.00e-15	<1.10e-14
7	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(4), ANAPC1(4), ANAPC10(2), ANAPC2(1), ANAPC4(4), ANAPC5(3), ANAPC7(4), ATM(37), ATR(17), BUB1(6), BUB1B(6), BUB3(2), CCNA1(6), CCNA2(3), CCNB1(2), CCNB2(2), CCNB3(7), CCND2(1), CCND3(1), CCNE1(3), CCNE2(2), CCNH(2), CDC14A(4), CDC14B(4), CDC16(4), CDC20(3), CDC23(6), CDC25A(2), CDC25B(5), CDC25C(4), CDC27(13), CDC6(1), CDC7(3), CDK2(2), CDK4(3), CDK6(1), CDK7(1), CDKN1A(1), CDKN1B(3), CDKN2A(1), CDKN2C(1), CHEK1(1), CHEK2(1), CREBBP(25), CUL1(8), DBF4(5), E2F2(1), E2F3(2), EP300(15), ESPL1(8), GSK3B(8), HDAC1(2), HDAC2(2), MAD1L1(2), MAD2L1(1), MAD2L2(1), MCM3(3), MCM4(4), MCM5(6), MCM6(4), MCM7(3), MDM2(4), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(3), PKMYT1(1), PLK1(8), PRKDC(18), PTTG1(1), RB1(7), RBL1(5), RBL2(8), RBX1(1), SKP1(1), SKP2(1), SMAD2(16), SMAD3(9), SMAD4(29), SMC1A(10), SMC1B(6), TFDP1(4), TGFB1(1), TGFB2(9), TP53(122), WEE1(3), YWHAB(2), YWHAE(3), YWHAH(1), YWHAQ(1)	46359792	561	182	490	105	172	159	112	9	105	4	<1.00e-15	<1.10e-14
8	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(2), AKT1(2), AKT2(6), AKT3(1), APAF1(8), ATM(37), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIRC2(4), BIRC3(7), CAPN1(2), CAPN2(6), CASP10(2), CASP3(2), CASP6(2), CASP7(1), CASP8(11), CASP9(2), CFLAR(3), CHUK(6), CSF2RB(7), DFFA(3), DFFB(2), FAS(2), FASLG(1), IKBKB(4), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(1), IL3(3), IRAK1(1), IRAK2(8), IRAK3(3), IRAK4(4), MAP3K14(3), MYD88(2), NFKB1(6), NFKB2(4), NTRK1(6), PIK3CA(40), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RELA(2), RIPK1(2), TNFRSF10A(3), TNFRSF10B(6), TNFRSF10C(6), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(1), TP53(122), TRADD(1), TRAF2(1)	28091296	424	181	343	69	136	131	73	2	78	4	<1.00e-15	<1.10e-14
9	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(187), AXIN1(2), CREBBP(25), CTNNB1(12), EP300(15), FZD1(1), GSK3B(8), HDAC1(2), LDB1(5), LEF1(4), PITX2(2), TRRAP(21), WNT1(1)	10969528	285	180	225	29	46	36	32	2	117	52	<1.00e-15	<1.10e-14
10	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(3), AKT1(2), APC(187), ASAH1(3), CAV3(3), DAG1(5), DLG4(3), EPHB2(8), GNAI1(4), GNAQ(4), ITPR1(19), ITPR2(18), ITPR3(12), KCNJ3(6), KCNJ5(4), KCNJ9(3), MAPK1(2), PITX2(2), PTX3(2), RHO(3), RYR1(25)	15764424	318	180	258	58	69	53	28	0	115	53	<1.00e-15	<1.10e-14
11	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(187), AXIN1(2), BTRC(5), CREBBP(25), CSNK1A1(2), CSNK1D(4), CSNK2A1(4), CTBP1(1), CTNNB1(12), FZD1(1), GSK3B(8), HDAC1(2), MAP3K7(4), NLK(1), PPARD(2), PPP2CA(1), TLE1(1), WIF1(2), WNT1(1)	9781784	265	178	206	26	34	31	31	2	115	52	<1.00e-15	<1.10e-14
12	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(4), ABL2(7), AKT1(2), AKT2(6), AKT3(1), ARAF(3), BAD(1), BRAF(23), BTC(2), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CBL(5), CBLB(8), CDKN1A(1), CDKN1B(3), CRKL(2), EGF(3), EGFR(11), ERBB2(10), ERBB3(14), ERBB4(21), EREG(1), GAB1(6), GRB2(3), GSK3B(8), HBEGF(1), KRAS(96), MAP2K1(4), MAP2K2(1), MAP2K4(11), MAPK1(2), MAPK10(8), MAPK3(3), MAPK8(7), MAPK9(5), NCK1(1), NRAS(20), NRG1(15), NRG2(6), NRG3(7), NRG4(1), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PIK3CA(40), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG1(4), PLCG2(13), PRKCA(4), PRKCG(10), PTK2(5), RAF1(6), RPS6KB1(3), RPS6KB2(2), SHC1(3), SHC2(1), SHC3(1), SHC4(5), SOS1(7), SOS2(11), SRC(3), STAT5B(3)	34832792	518	175	369	98	118	227	115	5	51	2	<1.00e-15	<1.10e-14
13	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ADRB1(3), CSNK1D(4), DRD1(1), DRD2(5), EGF(3), EGFR(11), GJA1(7), GJD2(1), GNA11(1), GNAI1(4), GNAQ(4), GNAS(6), GRB2(3), GRM1(12), GRM5(11), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(8), GUCY2D(8), GUCY2F(11), HTR2A(3), HTR2B(1), HTR2C(8), ITPR1(19), ITPR2(18), ITPR3(12), KRAS(96), MAP2K1(4), MAP2K2(1), MAP2K5(4), MAP3K2(3), MAPK1(2), MAPK3(3), MAPK7(3), NPR1(6), NPR2(10), NRAS(20), PDGFA(1), PDGFC(3), PDGFD(3), PDGFRA(17), PDGFRB(6), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKG1(9), PRKG2(5), PRKX(2), RAF1(6), SOS1(7), SOS2(11), SRC(3), TJP1(7), TUBA1B(2), TUBA1C(2), TUBA3C(9), TUBA3D(3), TUBA3E(5), TUBA4A(3), TUBA8(2), TUBAL3(4), TUBB(1), TUBB1(2), TUBB2A(3), TUBB2B(3), TUBB3(2), TUBB4(3), TUBB4Q(2), TUBB6(3), TUBB8(3)	44773672	598	175	497	177	196	266	87	4	42	3	<1.00e-15	<1.10e-14
14	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(187), CDH1(5), CREBBP(25), EP300(15), MAP2K1(4), MAP3K7(4), MAPK3(3), SKIL(1), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7)	8686152	270	175	210	25	34	35	30	1	118	52	<1.00e-15	<1.10e-14
15	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(18), ACACB(15), AKT1(2), AKT2(6), AKT3(1), ARAF(3), BAD(1), BRAF(23), CBL(5), CBLB(8), CRKL(2), EXOC7(2), FASN(1), FBP2(3), FLOT1(3), FOXO1(1), G6PC(4), G6PC2(1), GCK(2), GRB2(3), GSK3B(8), GYS1(2), GYS2(11), IKBKB(4), INPP5D(4), INSR(6), IRS1(8), IRS4(15), KRAS(96), LIPE(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK10(8), MAPK3(3), MAPK8(7), MAPK9(5), MKNK1(1), MKNK2(3), NRAS(20), PCK1(3), PCK2(3), PDE3A(5), PDE3B(3), PDPK1(1), PFKL(1), PFKM(4), PFKP(2), PHKA1(8), PHKA2(6), PHKB(6), PHKG2(3), PIK3CA(40), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PKM2(2), PPARGC1A(5), PPP1CB(2), PPP1CC(2), PPP1R3A(13), PPP1R3B(1), PPP1R3C(4), PPP1R3D(1), PRKAA1(3), PRKAA2(9), PRKAB1(2), PRKAB2(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKAG1(1), PRKAG2(3), PRKAG3(6), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCI(4), PRKX(2), PTPN1(5), PTPRF(9), PYGB(4), PYGL(2), PYGM(4), RAF1(6), RAPGEF1(6), RPS6KB1(3), RPS6KB2(2), SHC1(3), SHC2(1), SHC3(1), SHC4(5), SLC2A4(4), SOCS2(3), SOCS4(1), SORBS1(11), SOS1(7), SOS2(11), SREBF1(1), TSC1(4), TSC2(2)	53785020	606	172	461	157	160	259	127	5	53	2	<1.00e-15	<1.10e-14
16	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CREB1(1), CREB3(3), CREB3L1(3), CREB3L2(4), CREB3L3(3), CREB3L4(1), CREBBP(25), CTNNB1(12), DCT(13), DVL2(9), DVL3(4), EDN1(1), EDNRB(12), EP300(15), FZD1(1), FZD10(6), FZD2(2), FZD3(13), FZD4(2), FZD6(6), FZD7(3), FZD8(1), GNAI1(4), GNAO1(5), GNAQ(4), GNAS(6), GSK3B(8), KIT(8), KITLG(2), KRAS(96), LEF1(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MITF(5), NRAS(20), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), POMC(2), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), RAF1(6), TCF7(6), TCF7L1(3), TCF7L2(20), TYR(3), TYRP1(2), WNT1(1), WNT10B(4), WNT11(3), WNT16(2), WNT2(1), WNT2B(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2)	36670196	510	172	406	144	158	221	77	7	47	0	<1.00e-15	<1.10e-14
17	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(2), ADORA1(8), ADORA2A(5), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(5), ADRA2A(3), ADRA2B(1), ADRB1(3), ADRB3(1), AGTR1(5), AGTR2(5), AVPR1A(4), AVPR1B(3), AVPR2(6), BDKRB2(3), BRS3(3), C3AR1(4), C5AR1(3), CALCR(5), CALCRL(6), CCKAR(2), CCKBR(5), CGA(2), CHRM1(3), CHRM2(11), CHRM3(4), CHRM4(1), CHRM5(2), CNR1(5), CRHR1(2), CRHR2(5), CTSG(3), CYSLTR1(3), CYSLTR2(4), DRD1(1), DRD2(5), DRD3(3), DRD5(6), EDNRA(4), EDNRB(12), F2(3), F2RL1(1), F2RL2(3), FPR1(2), FSHB(2), FSHR(7), GABBR1(6), GABBR2(7), GABRA1(4), GABRA2(9), GABRA3(5), GABRA4(8), GABRA5(9), GABRA6(5), GABRB1(7), GABRB2(7), GABRB3(9), GABRE(5), GABRG1(9), GABRG2(11), GABRG3(5), GABRP(4), GABRQ(8), GABRR1(2), GABRR2(4), GALR1(2), GH1(2), GH2(3), GHR(6), GHRHR(2), GHSR(5), GLP1R(7), GLP2R(5), GLRA1(2), GLRA2(3), GLRA3(8), GLRB(7), GNRHR(4), GPR156(8), GPR50(5), GPR63(4), GPR83(1), GRIA1(19), GRIA2(13), GRIA3(8), GRIA4(19), GRID1(16), GRID2(12), GRIK1(5), GRIK2(14), GRIK3(19), GRIK4(12), GRIK5(6), GRIN1(1), GRIN2A(21), GRIN2B(10), GRIN2C(4), GRIN2D(5), GRIN3A(6), GRM1(12), GRM2(4), GRM3(7), GRM4(7), GRM5(11), GRM6(10), GRM7(12), GRM8(9), GRPR(3), GZMA(3), HCRTR1(1), HCRTR2(1), HRH1(1), HRH2(4), HRH4(2), HTR1A(5), HTR1B(5), HTR1D(2), HTR1E(7), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(8), HTR4(3), HTR5A(5), HTR7(7), LEP(1), LEPR(9), LHB(1), LHCGR(4), LTB4R(1), MAS1(2), MC2R(5), MC3R(1), MC4R(4), MC5R(6), MCHR1(6), MCHR2(3), MLNR(3), MTNR1B(3), NMUR1(4), NMUR2(9), NPBWR1(3), NPFFR2(4), NPY1R(4), NPY2R(5), NPY5R(2), NR3C1(4), NTSR1(1), NTSR2(5), OPRD1(1), OPRK1(5), OPRM1(3), OXTR(3), P2RX1(1), P2RX2(2), P2RX3(2), P2RX4(3), P2RX5(1), P2RX7(3), P2RY1(6), P2RY10(7), P2RY13(2), P2RY14(6), P2RY2(3), P2RY4(6), P2RY6(1), PARD3(7), PPYR1(4), PRL(3), PRLR(4), PRSS1(3), PRSS2(1), PRSS3(4), PTAFR(1), PTGDR(1), PTGER2(1), PTGER3(7), PTGFR(7), PTGIR(1), PTH2R(7), RXFP1(3), RXFP2(10), SCTR(3), SSTR1(5), SSTR2(3), SSTR4(4), TAAR1(4), TAAR2(2), TAAR5(6), TAAR6(5), TAAR8(2), TAAR9(3), TACR1(2), TACR2(1), TACR3(7), THRA(2), THRB(4), TRHR(8), TRPV1(4), TSHB(1), TSHR(7), VIPR1(4), VIPR2(3)	74184472	997	171	984	372	386	327	194	10	79	1	<1.00e-15	<1.10e-14
18	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(7), APC(187), AXIN1(2), BTRC(5), CTNNB1(12), DLL1(4), FZD1(1), GSK3B(8), PSEN1(3), WNT1(1)	6768668	230	170	171	14	22	23	20	1	112	52	<1.00e-15	<1.10e-14
19	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(187), ASAH1(3), CASP3(2), CERK(1), CREB1(1), CREB3(3), CREB5(4), DAG1(5), EPHB2(8), FOS(1), GNAQ(4), ITPKB(4), MAP2K4(11), MAPK1(2), MAPK10(8), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5)	9443440	260	170	199	25	26	36	28	2	116	52	<1.00e-15	<1.10e-14
20	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(3), BRAF(23), C7orf16(4), CACNA1A(17), CRHR1(2), GNA11(1), GNA12(2), GNA13(2), GNAI1(4), GNAO1(5), GNAQ(4), GNAS(6), GNAZ(1), GRIA1(19), GRIA2(13), GRIA3(8), GRID2(12), GRM1(12), GRM5(11), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(8), GUCY2D(8), GUCY2F(11), IGF1(2), IGF1R(8), ITPR1(19), ITPR2(18), ITPR3(12), KRAS(96), LYN(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), NOS1(11), NOS3(2), NPR1(6), NPR2(10), NRAS(20), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(2), PPP2R2A(1), PPP2R2B(3), PPP2R2C(4), PRKCA(4), PRKCG(10), PRKG1(9), PRKG2(5), RAF1(6), RYR1(25)	37797556	547	169	422	156	169	238	103	2	34	1	<1.00e-15	<1.10e-14
21	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(37), CCNA1(6), CCNB1(2), CCND2(1), CCND3(1), CCNE1(3), CCNE2(2), CCNH(2), CDC25A(2), CDK2(2), CDK4(3), CDK7(1), CDKN1A(1), CDKN1B(3), CDKN2A(1), CDKN2C(1), CREB3(3), CREB3L1(3), CREB3L3(3), CREB3L4(1), E2F2(1), E2F3(2), E2F4(1), E2F5(2), GBA2(5), MCM3(3), MCM4(4), MCM5(6), MCM6(4), MCM7(3), MDM2(4), MNAT1(1), MYT1(13), NACA(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(3), POLA2(2), POLE(21), POLE2(1), RB1(7), RBL1(5), RPA1(2), RPA2(1), TFDP1(4), TFDP2(1), TNXB(17), TP53(122), WEE1(3)	25477016	325	167	268	47	102	99	51	4	66	3	<1.00e-15	<1.10e-14
22	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(8), ATM(37), ATR(17), BAI1(2), BAX(1), BID(1), CASP3(2), CASP8(11), CASP9(2), CCNB1(2), CCNB2(2), CCNB3(7), CCND2(1), CCND3(1), CCNE1(3), CCNE2(2), CCNG1(3), CDK2(2), CDK4(3), CDK6(1), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(1), DDB2(1), EI24(1), FAS(2), GTSE1(2), IGF1(2), IGFBP3(4), MDM2(4), MDM4(3), PPM1D(4), PTEN(10), RCHY1(2), RFWD2(5), RPRM(1), RRM2(2), SERPINB5(2), SERPINE1(3), SESN1(2), SESN2(4), SESN3(6), SIAH1(1), STEAP3(1), THBS1(10), TNFRSF10B(6), TP53(122), TP53I3(2), TSC2(2), ZMAT3(5)	21750876	321	166	264	45	99	101	49	3	66	3	<1.00e-15	<1.10e-14
23	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(2), ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), AKT1(2), AKT2(6), AKT3(1), AMOTL1(13), ASH1L(24), CASK(4), CDC42(1), CDK4(3), CGN(7), CLDN10(4), CLDN11(1), CLDN15(1), CLDN16(5), CLDN17(5), CLDN18(2), CLDN19(1), CLDN2(1), CLDN6(2), CLDN7(2), CLDN8(5), CLDN9(1), CSDA(2), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTNNA1(12), CTNNA2(12), CTNNA3(9), CTNNB1(12), CTTN(1), EPB41(3), EPB41L1(9), EPB41L2(6), EPB41L3(18), EXOC4(7), F11R(1), GNAI1(4), HCLS1(8), IGSF5(8), INADL(5), JAM3(3), KRAS(96), LLGL1(1), LLGL2(2), MAGI1(13), MAGI2(11), MAGI3(6), MLLT4(6), MPDZ(11), MPP5(3), MRAS(1), MYH1(15), MYH10(10), MYH11(28), MYH13(15), MYH14(12), MYH15(12), MYH2(12), MYH3(14), MYH4(12), MYH6(12), MYH7(11), MYH7B(6), MYH8(20), MYH9(12), MYL2(1), MYL7(1), MYL9(2), NRAS(20), OCLN(1), PARD3(7), PARD6A(2), PARD6G(2), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(2), PPP2R2A(1), PPP2R2B(3), PPP2R2C(4), PPP2R3A(5), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCI(4), PRKCQ(5), PTEN(10), RAB3B(1), RHOA(5), RRAS2(2), SPTAN1(13), SRC(3), SYMPK(5), TJAP1(1), TJP1(7), TJP2(5), TJP3(1), YES1(1), ZAK(6)	65720716	734	166	623	199	263	291	103	4	69	4	<1.00e-15	<1.10e-14
24	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ATF4(1), CACNA1C(12), CACNA1D(8), CACNA1F(14), CACNA1S(14), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CDC42(1), CGA(2), EGFR(11), FSHB(2), GNA11(1), GNAQ(4), GNAS(6), GNRHR(4), GRB2(3), HBEGF(1), ITPR1(19), ITPR2(18), ITPR3(12), KRAS(96), LHB(1), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K4(11), MAP2K6(3), MAP3K1(8), MAP3K2(3), MAP3K3(3), MAP3K4(18), MAPK1(2), MAPK10(8), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK7(3), MAPK8(7), MAPK9(5), MMP14(4), MMP2(5), NRAS(20), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLD1(11), PLD2(2), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCD(3), PRKX(2), PTK2B(1), RAF1(6), SOS1(7), SOS2(11), SRC(3)	43936036	520	166	418	140	156	229	85	5	44	1	<1.00e-15	<1.10e-14
25	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(2), AKT2(6), AKT3(1), BCL10(3), CARD11(9), CBL(5), CBLB(8), CD247(2), CD28(2), CD3D(1), CD3G(2), CD4(2), CD40LG(6), CD8B(2), CDC42(1), CDK4(3), CHUK(6), CTLA4(2), FOS(1), FYN(5), GRAP2(5), GRB2(3), ICOS(1), IFNG(1), IKBKB(4), IL10(2), IL2(4), IL4(3), ITK(11), KRAS(96), LAT(1), LCK(3), LCP2(3), MALT1(7), MAP3K14(3), MAP3K8(2), NCK1(1), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), NRAS(20), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PDK1(2), PIK3CA(40), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKCQ(5), PTPN6(4), PTPRC(17), RASGRP1(5), RHOA(5), SOS1(7), SOS2(11), TEC(3), VAV1(13), VAV2(4), VAV3(12), ZAP70(4)	34226832	480	164	359	106	133	230	76	2	37	2	<1.00e-15	<1.10e-14
26	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(8), ADCY8(12), ARAF(3), ATF4(1), BRAF(23), CACNA1C(12), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), CREBBP(25), EP300(15), GNAQ(4), GRIA1(19), GRIA2(13), GRIN1(1), GRIN2A(21), GRIN2B(10), GRIN2C(4), GRIN2D(5), GRM1(12), GRM5(11), ITPR1(19), ITPR2(18), ITPR3(12), KRAS(96), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), NRAS(20), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PPP1CB(2), PPP1CC(2), PPP1R12A(3), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), RAF1(6), RAP1A(2), RAP1B(2), RAPGEF3(4), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA6(7)	34569584	489	162	370	131	148	197	104	3	35	2	<1.00e-15	<1.10e-14
27	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(2), AKT2(6), AKT3(1), BCL10(3), BLNK(1), BTK(7), CARD11(9), CD19(3), CD22(10), CD72(4), CD79A(3), CD79B(1), CHUK(6), CR2(11), FOS(1), GSK3B(8), IFITM1(1), IKBKB(4), INPP5D(4), KRAS(96), LILRB3(2), LYN(4), MALT1(7), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), NRAS(20), PIK3CA(40), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG2(13), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PTPN6(4), RASGRP3(7), SYK(3), VAV1(13), VAV2(4), VAV3(12)	25086584	394	157	272	64	111	195	57	1	28	2	<1.00e-15	<1.10e-14
28	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(2), ATF2(1), CDC42(1), DLD(1), DUSP10(5), DUSP4(1), GAB1(6), GCK(2), IL1R1(4), MAP2K4(11), MAP2K5(4), MAP3K1(8), MAP3K10(3), MAP3K11(4), MAP3K12(6), MAP3K13(9), MAP3K2(3), MAP3K3(3), MAP3K4(18), MAP3K5(6), MAP3K7(4), MAP3K9(4), MAPK10(8), MAPK7(3), MAPK8(7), MAPK9(5), MYEF2(7), NFATC3(5), NR2C2(4), PAPPA(18), SHC1(3), TP53(122), TRAF6(4), ZAK(6)	16967148	298	157	242	43	109	76	43	3	67	0	<1.00e-15	<1.10e-14
29	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(4), CDKN2A(1), MDM2(4), PIK3CA(40), PIK3R1(10), POLR1A(10), POLR1B(8), POLR1C(2), POLR1D(2), RB1(7), TP53(122)	6725016	210	156	137	13	67	54	40	2	44	3	<1.00e-15	<1.10e-14
30	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(4), ATM(37), ATR(17), CCNA1(6), CCNE1(3), CDC25A(2), CDK2(2), CDK4(3), CDK6(1), CDKN1A(1), CDKN1B(3), CDKN2A(1), DHFR(1), GSK3B(8), HDAC1(2), RB1(7), SKP2(1), TFDP1(4), TGFB1(1), TGFB2(9), TP53(122)	10113044	235	156	181	24	77	57	36	3	59	3	<1.00e-15	<1.10e-14
31	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(2), AKT2(6), AKT3(1), BTK(7), FCER1A(3), FYN(5), GAB2(1), GRB2(3), IL13(1), IL3(3), IL4(3), INPP5D(4), KRAS(96), LAT(1), LCP2(3), LYN(4), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K4(11), MAP2K6(3), MAPK1(2), MAPK10(8), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK8(7), MAPK9(5), MS4A2(3), NRAS(20), PDK1(2), PIK3CA(40), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLCG1(4), PLCG2(13), PRKCA(4), PRKCD(3), PRKCE(6), RAF1(6), SOS1(7), SOS2(11), SYK(3), VAV1(13), VAV2(4), VAV3(12)	24302180	399	156	274	63	97	195	72	3	30	2	<1.00e-15	<1.10e-14
32	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(8), BAD(1), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BCL2L11(3), BID(1), BIRC2(4), BIRC3(7), BNIP3L(3), CASP1(2), CASP10(2), CASP2(4), CASP3(2), CASP4(3), CASP6(2), CASP7(1), CASP8(11), CASP9(2), CHUK(6), DFFA(3), DFFB(2), FAS(2), FASLG(1), GZMB(2), HELLS(5), IKBKB(4), IRF1(1), IRF2(3), IRF3(2), IRF4(3), IRF5(3), IRF6(2), MAP2K4(11), MAP3K1(8), MAPK10(8), MDM2(4), NFKB1(6), NFKBIB(1), NFKBIE(2), RELA(2), RIPK1(2), TNFRSF10B(6), TNFRSF1A(1), TNFRSF21(5), TNFSF10(1), TP53(122), TRADD(1), TRAF1(2), TRAF2(1), TRAF3(6)	19216568	288	154	232	50	99	76	45	4	64	0	<1.00e-15	<1.10e-14
33	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(37), ATR(17), BRCA1(6), CCNB1(2), CDC25A(2), CDC25B(5), CDC25C(4), CDKN1A(1), CHEK1(1), CHEK2(1), EP300(15), MDM2(4), MYT1(13), PRKDC(18), RPS6KA1(1), TP53(122), WEE1(3), YWHAH(1), YWHAQ(1)	14583632	254	154	199	29	82	73	38	4	55	2	<1.00e-15	<1.10e-14
34	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(3), BAK1(1), BAX(1), BFAR(1), BTK(7), CAD(11), CASP10(2), CASP3(2), CASP8(11), CASP8AP2(18), CD7(1), CSNK1A1(2), DAXX(1), DEDD(1), DFFA(3), DIABLO(1), EGFR(11), EPHB2(8), FAF1(4), FAIM2(3), IL1A(1), IL8(1), MAP2K4(11), MAP3K1(8), MAP3K5(6), MAPK1(2), MAPK10(8), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), MET(5), NFAT5(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PFN2(1), PTPN13(17), RALBP1(6), RIPK1(2), ROCK1(15), SMPD1(6), TP53(122), TPX2(8), TRAF2(1), TUFM(1)	24826028	347	153	288	60	117	97	62	5	65	1	<1.00e-15	<1.10e-14
35	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(2), APAF1(8), ATM(37), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), CASP3(2), CASP6(2), CASP7(1), CASP9(2), PRKCA(4), PTK2(5), STAT1(6), TLN1(7), TP53(122)	9345948	203	152	149	21	67	55	26	2	51	2	<1.00e-15	<1.10e-14
36	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(8), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIRC2(4), BIRC3(7), CASP2(4), CASP3(2), CASP6(2), CASP7(1), CASP8(11), CASP9(2), FAS(2), FASLG(1), GZMB(2), MAP2K4(11), MAP3K1(8), MAP3K14(3), MAPK10(8), MDM2(4), NFKB1(6), PARP1(4), RELA(2), RIPK1(2), TNFRSF1A(1), TNFSF10(1), TP53(122), TRADD(1), TRAF1(2), TRAF2(1)	12612172	227	149	172	34	82	53	37	2	53	0	<1.00e-15	<1.10e-14
37	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(37), ATR(17), BRCA1(6), BRCA2(22), CHEK1(1), CHEK2(1), FANCA(7), FANCC(3), FANCD2(11), FANCF(2), FANCG(4), HUS1(1), MRE11A(8), RAD1(1), RAD17(4), RAD50(11), TP53(122), TREX1(2)	14895248	260	149	206	21	81	75	40	2	60	2	<1.00e-15	<1.10e-14
38	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(23), CPEB1(5), EGFR(11), ERBB2(10), ERBB4(21), ETS1(1), ETS2(3), ETV6(5), FMN2(7), GRB2(3), KRAS(96), MAP2K1(4), MAPK1(2), MAPK3(3), NOTCH2(13), NOTCH3(15), NOTCH4(7), PIWIL1(8), PIWIL2(10), PIWIL3(10), PIWIL4(8), RAF1(6), SOS1(7), SOS2(11), SPIRE1(3), SPIRE2(1)	17177932	293	149	184	50	55	156	64	3	15	0	<1.00e-15	<1.10e-14
39	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(11), AKT1(2), ATM(37), BAX(1), CDKN1A(1), CPB2(2), CSNK1A1(2), CSNK1D(4), FHL2(2), HIF1A(3), IGFBP3(4), MAPK8(7), MDM2(4), NFKBIB(1), NQO1(1), TP53(122)	6861780	204	149	150	10	63	54	32	4	49	2	<1.00e-15	<1.10e-14
40	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(4), ATM(37), BRCA1(6), CDKN1A(1), CHEK1(1), CHEK2(1), MAPK8(7), MDM2(4), MRE11A(8), NFKB1(6), RAD50(11), RBBP8(2), RELA(2), TP53(122)	10006120	212	146	158	16	68	58	31	3	50	2	<1.00e-15	<1.10e-14
41	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(37), ATR(17), CDC25C(4), CHEK1(1), CHEK2(1), TP53(122), YWHAH(1)	5383372	183	144	129	9	61	50	19	2	49	2	<1.00e-15	<1.10e-14
42	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(2), BCL2(1), EGFR(11), IGF1R(8), POLR2A(6), PPP2CA(1), PRKCA(4), RB1(7), TEP1(7), TERF1(1), TERT(2), TNKS(4), TP53(122), XRCC5(6)	9527844	182	144	129	22	75	38	23	3	42	1	<1.00e-15	<1.10e-14
43	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(25), DAXX(1), PAX3(7), PML(4), RB1(7), SIRT1(5), SP100(4), TNFRSF1A(1), TP53(122)	6411836	176	143	122	24	68	34	26	2	45	1	<1.00e-15	<1.10e-14
44	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	247	ACVR1(4), ACVR1B(15), ACVR2A(10), ACVR2B(4), AMHR2(2), BMP2(1), BMP7(6), BMPR1A(4), BMPR1B(10), BMPR2(10), CCL13(1), CCL15(1), CCL18(2), CCL22(1), CCL23(2), CCL27(3), CCL7(1), CCL8(1), CCR1(5), CCR3(4), CCR4(1), CCR5(1), CCR6(2), CCR7(3), CCR8(4), CCR9(6), CD27(3), CD40(1), CD40LG(6), CD70(5), CNTF(2), CNTFR(2), CSF1(2), CSF1R(3), CSF2RB(7), CSF3R(10), CX3CL1(1), CX3CR1(2), CXCL10(1), CXCL11(3), CXCL12(1), CXCL14(2), CXCL16(1), CXCL5(2), CXCL6(1), CXCL9(3), CXCR4(4), EDA(2), EDA2R(2), EDAR(3), EGF(3), EGFR(11), FAS(2), FASLG(1), FLT1(12), FLT3(5), FLT3LG(1), FLT4(5), GDF5(2), GH1(2), GH2(3), GHR(6), HGF(8), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(2), IFNK(1), IL10(2), IL10RA(2), IL10RB(5), IL11(1), IL11RA(1), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL13(1), IL13RA1(2), IL15(1), IL15RA(1), IL17A(2), IL17RA(6), IL17RB(1), IL18R1(10), IL18RAP(4), IL19(1), IL1A(1), IL1B(1), IL1R1(4), IL1R2(7), IL1RAP(1), IL2(4), IL20(3), IL20RA(5), IL21(2), IL21R(5), IL22(2), IL22RA1(1), IL23R(3), IL24(2), IL25(1), IL26(3), IL28RA(3), IL2RA(2), IL2RB(2), IL3(3), IL4(3), IL4R(1), IL5RA(6), IL6(2), IL6R(3), IL6ST(3), IL7(2), IL7R(3), IL8(1), IL9(2), INHBA(10), INHBB(1), INHBC(3), INHBE(1), KDR(10), KIT(8), KITLG(2), LEP(1), LEPR(9), LIFR(24), LTB(1), LTBR(3), MET(5), MPL(2), NGFR(3), OSM(1), OSMR(6), PDGFC(3), PDGFRA(17), PDGFRB(6), PLEKHO2(5), PRL(3), PRLR(4), RELT(2), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7), TNFRSF10A(3), TNFRSF10B(6), TNFRSF10C(6), TNFRSF10D(1), TNFRSF11A(3), TNFRSF11B(4), TNFRSF13B(4), TNFRSF17(2), TNFRSF19(3), TNFRSF1A(1), TNFRSF21(5), TNFRSF4(1), TNFRSF8(2), TNFRSF9(3), TNFSF10(1), TNFSF11(1), TNFSF12(2), TNFSF13(2), TNFSF13B(1), TNFSF14(3), TNFSF15(3), TNFSF18(1), TNFSF4(1), TNFSF8(1), TPO(11), TSLP(2), VEGFA(2), VEGFB(2), VEGFC(6), XCL2(1), XCR1(1)	58595148	643	129	628	208	197	233	123	1	87	2	<1.00e-15	<1.10e-14
45	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDK2(2), CDK4(3), CDKN1A(1), CDKN1B(3), CDKN2A(1), CFL1(1), E2F2(1), MDM2(4), NXT1(1), PRB1(1), TP53(122)	2706332	140	128	87	7	51	26	18	3	42	0	<1.00e-15	<1.10e-14
46	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(2), MAX(1), SP1(2), SP3(3), TP53(122), WT1(6)	2345036	136	128	83	6	56	25	15	2	38	0	<1.00e-15	<1.10e-14
47	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(2), ACTB(2), ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), ACVR1B(15), ACVR1C(3), BAIAP2(1), CDC42(1), CDH1(5), CREBBP(25), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTNNA1(12), CTNNA2(12), CTNNA3(9), CTNNB1(12), CTNND1(6), EGFR(11), EP300(15), ERBB2(10), FARP2(5), FER(6), FGFR1(4), FYN(5), IGF1R(8), INSR(6), IQGAP1(13), LEF1(4), LMO7(19), MAP3K7(4), MAPK1(2), MAPK3(3), MET(5), MLLT4(6), NLK(1), PARD3(7), PTPN1(5), PTPN6(4), PTPRB(4), PTPRF(9), PTPRJ(4), PTPRM(27), PVRL1(6), PVRL2(4), PVRL3(2), PVRL4(4), RHOA(5), SMAD2(16), SMAD3(9), SMAD4(29), SNAI1(1), SNAI2(2), SORBS1(11), SRC(3), SSX2IP(4), TCF7(6), TCF7L1(3), TCF7L2(20), TGFBR1(9), TGFBR2(7), TJP1(7), VCL(2), WAS(1), WASF1(3), WASF2(2), WASF3(4), WASL(7), YES1(1)	40431356	487	126	466	124	173	155	91	6	60	2	<1.00e-15	<1.10e-14
48	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(6), DNAJC3(1), EIF2S2(1), MAP3K14(3), NFKB1(6), RELA(2), TP53(122)	3440416	141	126	88	9	59	24	16	2	40	0	<1.00e-15	<1.10e-14
49	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(4), ACVR1B(15), ACVR1C(3), ACVR2A(10), ACVR2B(4), ACVRL1(4), AMHR2(2), BMP2(1), BMP4(2), BMP5(5), BMP6(3), BMP7(6), BMP8A(1), BMPR1A(4), BMPR1B(10), BMPR2(10), CHRD(5), COMP(2), CREBBP(25), CUL1(8), DCN(4), E2F4(1), E2F5(2), EP300(15), FST(3), GDF5(2), GDF6(3), IFNG(1), INHBA(10), INHBB(1), INHBC(3), INHBE(1), LTBP1(9), MAPK1(2), MAPK3(3), NODAL(1), PITX2(2), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(2), PPP2R2A(1), PPP2R2B(3), PPP2R2C(4), RBL1(5), RBL2(8), RBX1(1), RHOA(5), ROCK1(15), ROCK2(6), RPS6KB1(3), RPS6KB2(2), SKP1(1), SMAD1(2), SMAD2(16), SMAD3(9), SMAD4(29), SMAD5(1), SMAD9(3), SMURF1(3), SMURF2(2), SP1(2), TFDP1(4), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7), THBS1(10), THBS2(15), THBS3(3), THBS4(2), ZFYVE16(12), ZFYVE9(10)	33483880	399	112	382	115	131	122	81	1	62	2	<1.00e-15	<1.10e-14
50	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(2), ASAH1(3), ATF1(2), BRAF(23), CREB1(1), CREB3(3), CREB5(4), CREBBP(25), CRKL(2), DAG1(5), EGR1(3), EGR2(8), EGR3(2), FRS2(4), GNAQ(4), MAP1B(30), MAP2K4(11), MAPK1(2), MAPK10(8), MAPK3(3), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), NTRK1(6), OPN1LW(1), PIK3C2G(9), PIK3CA(40), PIK3CD(3), PIK3R1(10), PTPN11(5), RPS6KA3(5), SHC1(3), SRC(3), TERF2IP(2)	17408808	248	99	205	58	57	77	76	2	33	3	<1.00e-15	<1.10e-14
51	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(8), ARHGEF1(5), F2(3), GNA12(2), GNA13(2), GNAI1(4), GNAQ(4), GNB1(1), GNGT1(1), MAP3K7(4), PIK3CA(40), PIK3R1(10), PLCB1(8), PPP1R12B(9), PRKCA(4), PTK2B(1), ROCK1(15)	8727252	121	66	100	26	30	39	31	2	17	2	<1.00e-15	<1.10e-14
52	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(6), HLA-A(3), ITGB1(6), KLRC3(3), KLRC4(1), KLRD1(1), LAT(1), MAP2K1(4), MAPK3(3), PAK1(5), PIK3CA(40), PIK3R1(10), PTK2B(1), PTPN6(4), SYK(3), VAV1(13)	6304680	104	61	83	14	25	34	28	1	13	3	<1.00e-15	<1.10e-14
53	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(2), GRB2(3), KLK2(3), NTRK1(6), PIK3CA(40), PIK3R1(10), PLCG1(4), PRKCA(4), SHC1(3), SOS1(7)	5265548	82	60	59	12	14	36	23	0	7	2	<1.00e-15	<1.10e-14
54	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(2), CD3D(1), CD3G(2), CD80(1), CTLA4(2), GRB2(3), HLA-DRA(5), HLA-DRB1(2), ICOS(1), IL2(4), ITK(11), LCK(3), PIK3CA(40), PIK3R1(10), PTPN11(5)	4232504	92	56	71	12	21	39	21	0	7	4	<1.00e-15	<1.10e-14
55	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(2), PIK3CA(40), PIK3R1(10), PLCB1(8), PLCG1(4), PRKCA(4), VAV1(13)	4350156	81	56	61	14	22	29	21	1	6	2	<1.00e-15	<1.10e-14
56	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(3), CDK2(2), CUL1(8), FBXW7(45), RB1(7), TFDP1(4)	2879528	69	46	52	8	28	9	14	3	14	1	<1.00e-15	<1.10e-14
57	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(4), APC(187), ATF2(1), AXIN1(2), BMP10(3), BMP2(1), BMP4(2), BMP5(5), BMP7(6), BMPR1A(4), BMPR2(10), CHRD(5), CTNNB1(12), FZD1(1), GATA4(1), GSK3B(8), MAP3K7(4), MEF2C(9), MYL2(1), NKX2-5(1), NPPA(1), NPPB(1), RFC1(14), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7), TGFBR3(8), WNT1(1)	12081204	318	185	257	34	50	54	35	1	126	52	1.11e-15	1.18e-14
58	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(4), ATM(37), BUB1(6), BUB1B(6), BUB3(2), CCNA1(6), CCNA2(3), CCNB1(2), CCNB2(2), CCNB3(7), CCND2(1), CCND3(1), CCNE1(3), CCNE2(2), CCNH(2), CDAN1(3), CDC14A(4), CDC14B(4), CDC20(3), CDC25A(2), CDC25B(5), CDC25C(4), CDC6(1), CDC7(3), CDH1(5), CDK2(2), CDK4(3), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(1), DTX4(3), E2F2(1), E2F3(2), E2F4(1), E2F5(2), EP300(15), ESPL1(8), GSK3B(8), HDAC1(2), HDAC2(2), HDAC3(2), HDAC4(5), HDAC5(2), HDAC6(6), MAD1L1(2), MAD2L1(1), MAD2L2(1), MCM3(3), MCM4(4), MCM5(6), MCM6(4), MCM7(3), MDM2(4), MPEG1(4), MPL(2), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(3), PLK1(8), PRKDC(18), PTPRA(2), PTTG1(1), RB1(7), RBL1(5), SKP2(1), SMAD4(29), TBC1D8(5), TFDP1(4), TGFB1(1), TP53(122), WEE1(3)	37834220	433	178	369	75	131	122	88	8	80	4	1.11e-15	1.18e-14
59	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(2), APC(187), AR(6), ASAH1(3), BRAF(23), CCL13(1), CCL15(1), DAG1(5), EGFR(11), GNA11(1), GNA15(3), GNAI1(4), GNAQ(4), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), KCNJ3(6), KCNJ5(4), KCNJ9(3), MAPK1(2), MAPK10(8), MAPK14(3), PHKA2(6), PIK3CA(40), PIK3CD(3), PIK3R1(10), PITX2(2), PTX3(2), RAF1(6), SRC(3)	18222276	402	191	303	61	77	74	76	0	120	55	1.22e-15	1.25e-14
60	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(2), AKT2(6), AKT3(1), BAD(1), CASP9(2), CDC42(1), KDR(10), KRAS(96), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPKAPK2(3), MAPKAPK3(1), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NOS3(2), NRAS(20), PIK3CA(40), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLCG1(4), PLCG2(13), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKCA(4), PRKCG(10), PTGS2(3), PTK2(5), RAF1(6), SH2D2A(2), SHC2(1), SPHK1(1), SPHK2(1), SRC(3), VEGFA(2)	24278208	341	155	220	67	94	165	51	0	29	2	1.22e-15	1.25e-14
61	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	125	ARAF(3), BID(1), BRAF(23), CASP3(2), CD244(3), CD247(2), FAS(2), FASLG(1), FCGR3A(1), FYN(5), GRB2(3), GZMB(2), HLA-A(3), HLA-B(3), HLA-C(2), HLA-E(1), HLA-G(2), ICAM1(2), ICAM2(1), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(2), ITGAL(8), ITGB2(5), KIR2DL1(2), KIR2DL3(1), KIR2DL4(2), KIR3DL1(4), KIR3DL2(4), KLRC3(3), KLRD1(1), KLRK1(3), KRAS(96), LAT(1), LCK(3), LCP2(3), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MICB(3), NCR1(1), NCR3(1), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NRAS(20), PAK1(5), PIK3CA(40), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG1(4), PLCG2(13), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKCA(4), PRKCG(10), PTK2B(1), PTPN11(5), PTPN6(4), RAF1(6), SH2D1A(2), SH2D1B(1), SH3BP2(1), SHC1(3), SHC2(1), SHC3(1), SHC4(5), SOS1(7), SOS2(11), SYK(3), TNFRSF10A(3), TNFRSF10B(6), TNFRSF10C(6), TNFRSF10D(1), TNFSF10(1), TYROBP(1), ULBP1(2), ULBP2(2), VAV1(13), VAV2(4), VAV3(12), ZAP70(4)	38003024	521	169	375	100	123	242	106	2	44	4	1.33e-15	1.32e-14
62	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(2), CADM1(8), CADM3(8), CD2(3), CD22(10), CD226(4), CD274(4), CD28(2), CD34(1), CD4(2), CD40(1), CD40LG(6), CD58(2), CD6(3), CD80(1), CD8B(2), CDH1(5), CDH15(1), CDH2(22), CDH3(4), CDH4(11), CDH5(2), CLDN10(4), CLDN11(1), CLDN15(1), CLDN16(5), CLDN17(5), CLDN18(2), CLDN19(1), CLDN2(1), CLDN6(2), CLDN7(2), CLDN8(5), CLDN9(1), CNTN1(17), CNTN2(7), CNTNAP1(7), CNTNAP2(12), CTLA4(2), ESAM(3), F11R(1), GLG1(4), HLA-A(3), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DMB(1), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(1), HLA-DRA(5), HLA-DRB1(2), HLA-DRB5(1), HLA-E(1), HLA-F(2), HLA-G(2), ICAM1(2), ICAM2(1), ICOS(1), ITGA4(8), ITGA6(4), ITGA8(8), ITGA9(6), ITGAL(8), ITGAM(8), ITGAV(5), ITGB1(6), ITGB2(5), ITGB7(4), ITGB8(5), JAM3(3), L1CAM(4), MAG(7), MPZL1(1), NCAM1(6), NCAM2(16), NEGR1(4), NEO1(6), NFASC(17), NLGN1(7), NLGN2(2), NLGN3(4), NRCAM(7), NRXN1(24), NRXN2(6), NRXN3(18), OCLN(1), PDCD1LG2(1), PECAM1(2), PTPRC(17), PTPRF(9), PTPRM(27), PVR(1), PVRL1(6), PVRL2(4), PVRL3(2), SDC1(1), SDC2(3), SDC3(3), SDC4(1), SELE(4), SELL(3), SELP(6), SELPLG(2), SIGLEC1(4), SPN(2), VCAM1(9), VCAN(36)	49549548	568	129	556	200	185	199	105	8	67	4	1.33e-15	1.32e-14
63	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(6), AKT3(1), ANKRD6(5), APC(187), AXIN1(2), AXIN2(9), CER1(3), CSNK1A1(2), CTNNB1(12), DACT1(6), DKK1(5), DKK2(6), DKK3(2), DKK4(7), FSTL1(6), GSK3A(2), GSK3B(8), LRP1(17), MVP(4), NKD1(3), NKD2(1), PIN1(1), PSEN1(3), PTPRA(2), SENP2(3), SFRP1(3), TSHB(1), WIF1(2)	13605284	311	185	249	37	60	43	39	1	116	52	1.44e-15	1.39e-14
64	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(37), CDC25A(2), CDC25B(5), CDC25C(4), CDK2(2), CDK4(3), CHEK1(1), MYT1(13), RB1(7), TP53(122), WEE1(3), YWHAH(1)	6001088	200	152	145	12	64	54	26	4	49	3	1.44e-15	1.39e-14
65	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), AKAP10(3), AKAP11(7), AKAP12(14), AKAP3(10), AKAP4(4), AKAP5(3), AKAP6(16), AKAP7(3), AKAP8(3), AKAP9(26), ARHGEF1(5), GNA11(1), GNA12(2), GNA13(2), GNA14(6), GNA15(3), GNAL(4), GNAO1(5), GNAQ(4), GNAZ(1), GNB1(1), GNB3(3), GNB5(1), GNG3(2), GNG4(1), GNG7(1), GNGT1(1), IL18BP(2), ITPR1(19), KCNJ3(6), KRAS(96), NRAS(20), PDE1A(4), PDE1B(3), PDE1C(9), PDE4A(4), PDE4B(5), PDE4C(2), PDE4D(4), PDE7A(3), PDE7B(4), PDE8A(1), PDE8B(7), PLCB3(4), PPP3CA(3), PPP3CC(4), PRKACA(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCI(4), PRKCQ(5), PRKD1(15), PRKD3(8), RHOA(5), SLC9A1(4), USP5(4)	39769232	485	159	382	135	136	228	68	2	49	2	1.67e-15	1.58e-14
66	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(4), IFNG(1), IFNGR1(3), IFNGR2(2), IKBKB(4), JAK2(9), LIN7A(2), NFKB1(6), RB1(7), RELA(2), TNFRSF1A(1), TP53(122), USH1C(8), WT1(6)	6124092	177	136	124	20	66	40	21	2	45	3	1.89e-15	1.76e-14
67	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(8), ATM(37), BAX(1), BCL2(1), CCNE1(3), CDK2(2), CDK4(3), CDKN1A(1), MDM2(4), PCNA(3), RB1(7), TIMP3(3), TP53(122)	6193464	195	150	141	14	61	52	27	3	49	3	2.22e-15	2.01e-14
68	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(7), FCER1A(3), FOS(1), GRB2(3), LYN(4), MAP2K1(4), MAP2K4(11), MAP3K1(8), MAPK1(2), MAPK3(3), MAPK8(7), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PAK2(3), PIK3CA(40), PIK3R1(10), PLA2G4A(8), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), RAF1(6), SHC1(3), SOS1(7), SYK(3), SYT1(1), VAV1(13)	14318552	180	84	156	33	57	55	41	1	24	2	2.22e-15	2.01e-14
69	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(2), CDKN1B(3), GRB2(3), ITGB1(6), MAPK1(2), MAPK3(3), PDK2(2), PDPK1(1), PIK3CA(40), PIK3R1(10), PTEN(10), PTK2(5), SHC1(3), SOS1(7)	6495600	97	58	74	14	17	35	28	0	14	3	2.55e-15	2.28e-14
70	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(2), CAT(3), GH1(2), GHR(6), IGF1(2), IGF1R(8), PIK3CA(40), PIK3R1(10), SHC1(3), SOD2(4)	4455064	80	55	59	15	22	29	21	0	6	2	4.11e-15	3.61e-14
71	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(2), ARPC2(2), CDC42(1), PAK1(5), PDGFRA(17), PIK3CA(40), PIK3R1(10), WASL(7)	4520368	94	49	74	16	20	33	26	1	11	3	4.77e-15	4.14e-14
72	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(2), GORASP1(4), MAP2K4(11), MAPK1(2), MAPK10(8), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), MAPKAPK5(1), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PIK3CA(40), PIK3CD(3), PIK3R1(10), SYT1(1), TRAF2(1), TRAF3(6), TRAF5(6), TRAF6(4)	11080912	137	76	116	29	33	41	35	4	22	2	8.10e-15	6.93e-14
73	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3D(1), CD3G(2), FOS(1), FYN(5), GRB2(3), LAT(1), LCK(3), MAP2K1(4), MAP2K4(11), MAP3K1(8), MAPK3(3), MAPK8(7), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB1(6), PIK3CA(40), PIK3R1(10), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKCA(4), PTPN7(2), RAF1(6), RASA1(9), RELA(2), SHC1(3), SOS1(7), SYT1(1), VAV1(13), ZAP70(4)	16032496	189	85	166	39	64	58	38	1	26	2	1.08e-14	9.09e-14
74	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(2), CREB1(1), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAPK1(2), MAPK14(3), MAPK3(3), NFKB1(6), PIK3CA(40), PIK3R1(10), RB1(7), RELA(2), SP1(2)	6637840	100	59	80	15	25	33	28	2	9	3	2.03e-14	1.69e-13
75	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(2), BAD(1), GRB2(3), IGF1R(8), IRS1(8), MAP2K1(4), MAPK1(2), MAPK3(3), PIK3CA(40), PIK3R1(10), RAF1(6), SHC1(3), SOS1(7), YWHAH(1)	6293804	98	62	76	13	24	37	26	0	9	2	2.75e-14	2.26e-13
76	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(4), FOS(1), GRB2(3), JAK1(4), MAP2K1(4), MAP2K4(11), MAP3K1(8), MAPK3(3), MAPK8(7), PDGFA(1), PDGFRA(17), PIK3CA(40), PIK3R1(10), PLCG1(4), PRKCA(4), RAF1(6), RASA1(9), SHC1(3), SOS1(7), SRF(3), STAT1(6), STAT3(2)	11726128	157	73	133	29	40	56	41	1	16	3	5.74e-14	4.65e-13
77	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(2), BAD(1), CASP9(2), CHUK(6), GH1(2), GHR(6), NFKB1(6), PDPK1(1), PIK3CA(40), PIK3R1(10), PPP2CA(1), RELA(2), YWHAH(1)	4786224	80	52	60	12	21	27	24	0	6	2	9.07e-14	7.26e-13
78	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CHRNB1(3), CHRNG(3), MUSK(4), PIK3CA(40), PIK3R1(10), PTK2(5), PTK2B(1), RAPSN(2), SRC(3), TERT(2), YWHAH(1)	5633432	77	55	57	18	18	27	18	1	11	2	1.20e-13	9.50e-13
79	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(2), EIF4A2(5), EIF4G1(9), EIF4G2(7), EIF4G3(11), GHR(6), IRS1(8), MAPK1(2), MAPK14(3), MAPK3(3), MKNK1(1), PABPC1(3), PDK2(2), PDPK1(1), PIK3CA(40), PIK3R1(10), PRKCA(4), PTEN(10), RPS6KB1(3)	9422708	130	67	107	23	29	46	34	3	15	3	1.27e-13	9.94e-13
80	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(2), BAD(1), BCL2L1(1), CASP9(2), CDC42(1), CHUK(6), MAP2K1(4), MAPK3(3), NFKB1(6), PIK3CA(40), PIK3R1(10), RAF1(6), RALA(1), RALBP1(6), RALGDS(1), RELA(2), RHOA(5)	6494360	97	59	76	13	31	25	29	0	10	2	3.04e-13	2.34e-12
81	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	CXCL12(1), CXCR4(4), GNAI1(4), GNAQ(4), GNB1(1), GNGT1(1), MAP2K1(4), MAPK1(2), MAPK3(3), NFKB1(6), PIK3C2G(9), PIK3CA(40), PIK3R1(10), PLCG1(4), PRKCA(4), PTK2(5), PTK2B(1), RAF1(6), RELA(2)	9496652	111	66	90	21	34	35	26	0	14	2	3.45e-13	2.63e-12
82	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	146	AKT1(2), AKT2(6), AKT3(1), BCL2L1(1), CBL(5), CBLB(8), CCND2(1), CCND3(1), CNTF(2), CNTFR(2), CREBBP(25), CSF2RB(7), CSF3R(10), EP300(15), GH1(2), GH2(3), GHR(6), GRB2(3), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(2), IFNK(1), IL10(2), IL10RA(2), IL10RB(5), IL11(1), IL11RA(1), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL13(1), IL13RA1(2), IL13RA2(3), IL15(1), IL15RA(1), IL19(1), IL2(4), IL20(3), IL20RA(5), IL21(2), IL21R(5), IL22(2), IL22RA1(1), IL23R(3), IL24(2), IL26(3), IL28RA(3), IL2RA(2), IL2RB(2), IL3(3), IL4(3), IL4R(1), IL5RA(6), IL6(2), IL6R(3), IL6ST(3), IL7(2), IL7R(3), IL9(2), IRF9(3), JAK1(4), JAK2(9), JAK3(8), LEP(1), LEPR(9), LIFR(24), MPL(2), OSM(1), OSMR(6), PIAS1(4), PIAS2(3), PIAS3(4), PIAS4(1), PIK3CA(40), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PIM1(1), PRL(3), PRLR(4), PTPN11(5), PTPN6(4), SOCS2(3), SOCS4(1), SOCS5(4), SOS1(7), SOS2(11), SPRED1(7), SPRED2(6), SPRY1(3), SPRY4(2), STAM(2), STAM2(2), STAT1(6), STAT2(7), STAT3(2), STAT4(3), STAT5B(3), STAT6(2), TPO(11), TSLP(2), TYK2(1)	47841532	488	125	460	136	155	175	99	2	53	4	5.29e-13	3.98e-12
83	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(8), AKT1(2), ASAH1(3), GNAI1(4), GNB1(1), GNGT1(1), ITGAV(5), ITGB3(9), MAPK1(2), MAPK3(3), PDGFA(1), PDGFRA(17), PIK3CA(40), PIK3R1(10), PLCB1(8), PRKCA(4), PTK2(5), SMPD1(6), SPHK1(1), SRC(3)	9192876	133	68	113	33	35	43	36	2	14	3	6.41e-13	4.76e-12
84	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), GSK3B(8), IGF1(2), IGF1R(8), INPPL1(4), PDK2(2), PDPK1(1), PIK3CA(40), PIK3R1(10), PPP2CA(1), PTEN(10), RPS6KB1(3)	6667456	98	58	76	16	26	31	25	0	13	3	1.60e-12	1.17e-11
85	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	AKT1(2), ANXA1(1), GNAS(6), GNB1(1), GNGT1(1), NFKB1(6), NOS3(2), NPPA(1), NR3C1(4), PIK3CA(40), PIK3R1(10), RELA(2), SYT1(1)	5990252	77	57	57	18	21	26	20	0	8	2	3.46e-12	2.51e-11
86	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(4), EGF(3), EGFR(11), FOS(1), GRB2(3), JAK1(4), MAP2K1(4), MAP2K4(11), MAP3K1(8), MAPK3(3), MAPK8(7), PIK3CA(40), PIK3R1(10), PLCG1(4), PRKCA(4), RAF1(6), RASA1(9), SHC1(3), SOS1(7), SRF(3), STAT1(6), STAT3(2)	12623248	153	75	129	26	45	52	40	1	13	2	3.56e-12	2.55e-11
87	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(4), FOS(1), GRB2(3), KLK2(3), MAP2K1(4), MAPK3(3), MAPK8(7), NGFR(3), PIK3CA(40), PIK3R1(10), PLCG1(4), RAF1(6), SHC1(3), SOS1(7)	6403844	98	58	74	12	22	38	28	1	7	2	5.01e-12	3.55e-11
88	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(4), FOS(1), GRB2(3), IGF1(2), IGF1R(8), IRS1(8), MAP2K1(4), MAPK3(3), MAPK8(7), PIK3CA(40), PIK3R1(10), PTPN11(5), RAF1(6), RASA1(9), SHC1(3), SOS1(7), SRF(3)	8258540	123	65	101	16	30	46	33	1	11	2	6.47e-12	4.53e-11
89	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(8), AKT1(2), BAD(1), BAX(1), BCL2(1), BCL2L1(1), CSF2RB(7), IGF1(2), IGF1R(8), IL3(3), KIT(8), KITLG(2), PIK3CA(40), PIK3R1(10), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), YWHAH(1)	7046604	108	63	87	26	35	38	24	0	9	2	1.25e-11	8.62e-11
90	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(1), CREBBP(25), EP300(15), FYN(5), IL7(2), IL7R(3), JAK1(4), JAK3(8), LCK(3), NMI(2), PIK3CA(40), PIK3R1(10), PTK2B(1), STAT5B(3)	9513048	122	65	101	27	32	44	29	1	14	2	1.33e-11	9.09e-11
91	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(9), DIAPH1(1), FYN(5), ITGA1(3), ITGB1(6), MAP2K1(4), MAPK1(2), MAPK3(3), MYL2(1), MYLK(14), PIK3CA(40), PIK3R1(10), PTK2(5), RAF1(6), ROCK1(15), SHC1(3), SRC(3), TLN1(7)	12760120	137	74	114	26	35	49	34	0	17	2	1.37e-11	9.24e-11
92	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(2), ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), AKT1(2), AKT2(6), AKT3(1), ARHGAP5(9), BAD(1), BCL2(1), BIRC2(4), BIRC3(7), BRAF(23), CAPN2(6), CAV1(1), CAV2(1), CAV3(3), CCND2(1), CCND3(1), CDC42(1), CHAD(7), COL11A1(24), COL11A2(11), COL1A1(11), COL1A2(16), COL2A1(9), COL3A1(12), COL4A1(14), COL4A2(4), COL4A4(10), COL4A6(15), COL5A1(15), COL5A2(13), COL5A3(10), COL6A2(1), COL6A3(43), COL6A6(20), COMP(2), CRKL(2), CTNNB1(12), DIAPH1(1), DOCK1(7), EGF(3), EGFR(11), ERBB2(10), FARP2(5), FIGF(2), FLNA(3), FLNB(16), FLNC(13), FLT1(12), FN1(21), FYN(5), GRB2(3), GRLF1(12), GSK3B(8), HGF(8), IBSP(3), IGF1(2), IGF1R(8), ITGA1(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGAV(5), ITGB1(6), ITGB3(9), ITGB4(3), ITGB5(6), ITGB6(6), ITGB7(4), ITGB8(5), KDR(10), LAMA1(24), LAMA2(25), LAMA3(18), LAMA4(11), LAMB1(8), LAMB2(5), LAMB3(9), LAMB4(16), LAMC1(11), LAMC2(10), LAMC3(8), MAP2K1(4), MAPK1(2), MAPK10(8), MAPK3(3), MAPK8(7), MAPK9(5), MET(5), MYL2(1), MYL7(1), MYL9(2), MYLK(14), MYLK2(3), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PARVA(1), PARVB(5), PARVG(3), PDGFA(1), PDGFC(3), PDGFD(3), PDGFRA(17), PDGFRB(6), PDPK1(1), PGF(2), PIK3CA(40), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PIP5K1C(4), PPP1CB(2), PPP1CC(2), PPP1R12A(3), PRKCA(4), PRKCG(10), PTEN(10), PTK2(5), RAF1(6), RAP1A(2), RAP1B(2), RAPGEF1(6), RELN(33), RHOA(5), ROCK1(15), ROCK2(6), SHC1(3), SHC2(1), SHC3(1), SHC4(5), SOS1(7), SOS2(11), SPP1(1), SRC(3), THBS1(10), THBS2(15), THBS3(3), THBS4(2), TLN1(7), TLN2(8), TNC(16), TNN(17), TNR(21), TNXB(17), VASP(3), VAV1(13), VAV2(4), VAV3(12), VCL(2), VEGFA(2), VEGFB(2), VEGFC(6), VTN(6), VWF(15), ZYX(1)	125133344	1281	177	1222	447	447	422	252	12	143	5	1.68e-11	1.12e-10
93	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(2), CREB1(1), GRB2(3), MAPK1(2), MAPK3(3), MAPK7(3), MEF2A(4), MEF2C(9), MEF2D(1), NTRK1(6), PIK3CA(40), PIK3R1(10), PLCG1(4), RPS6KA1(1), SHC1(3)	6560084	92	57	71	17	23	29	29	0	9	2	1.72e-11	1.14e-10
94	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(2), CDK5R1(1), CFL1(1), CHN1(2), LIMK1(5), MAP3K1(8), MYL2(1), MYLK(14), NCF2(2), PAK1(5), PDGFRA(17), PIK3CA(40), PIK3R1(10), PLD1(11), PPP1R12B(9), RALBP1(6), RPS6KB1(3), TRIO(13), VAV1(13), WASF1(3)	11823488	166	75	144	35	47	56	37	2	21	3	2.13e-11	1.40e-10
95	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(2), AKT2(6), AKT3(1), BPNT1(1), GRB2(3), MAPK1(2), MAPK3(3), PDK1(2), PIK3CA(40), PIK3CD(3), PTEN(10), PTK2B(1), RBL2(8), SHC1(3), SOS1(7)	6860600	92	53	70	17	20	35	25	0	11	1	2.97e-11	1.92e-10
96	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(4), FOS(1), GRB2(3), INSR(6), IRS1(8), MAP2K1(4), MAPK3(3), MAPK8(7), PIK3CA(40), PIK3R1(10), PTPN11(5), RAF1(6), RASA1(9), SHC1(3), SLC2A4(4), SOS1(7), SRF(3)	8516060	123	64	101	20	27	47	34	1	12	2	3.06e-11	1.97e-10
97	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(2), CCNE1(3), CDK2(2), CDK4(3), CDK6(1), CDKN1A(1), CDKN1B(3), MAPK1(2), MAPK3(3), NFKB1(6), PAK1(5), PIK3CA(40), PIK3R1(10), RAF1(6), RB1(7), RELA(2), TFDP1(4)	6887892	100	55	79	14	26	29	29	2	11	3	4.26e-11	2.71e-10
98	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(2), BCL2(1), BCR(7), CRKL(2), FOS(1), GRB2(3), JAK2(9), MAP2K1(4), MAP2K4(11), MAP3K1(8), MAPK3(3), MAPK8(7), PIK3CA(40), PIK3R1(10), RAF1(6), SOS1(7), STAT1(6), STAT5B(3)	9328704	130	65	108	18	36	44	35	1	10	4	1.39e-10	8.71e-10
99	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(3), ACTN2(8), ACTN3(3), ACTN4(3), DES(1), DMD(47), FAM48A(6), MYBPC1(7), MYBPC2(4), MYBPC3(3), MYH3(14), MYH6(12), MYH7(11), MYH8(20), MYL1(1), MYL2(1), MYL4(1), MYL9(2), MYOM1(12), NEB(54), TMOD1(3), TNNC2(1), TNNI1(2), TNNI3(1), TNNT2(3), TPM1(2), TPM2(6), TPM3(3), TPM4(4), TTN(290), VIM(3)	47291536	535	119	522	154	174	197	111	5	40	8	1.69e-10	1.05e-09
100	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(4), FOS(1), GRB2(3), JAK2(9), MAP2K1(4), MAPK3(3), MPL(2), PIK3CA(40), PIK3R1(10), PLCG1(4), PRKCA(4), RAF1(6), RASA1(9), SHC1(3), SOS1(7), STAT1(6), STAT3(2), STAT5B(3), THPO(2)	10112292	122	63	100	21	29	46	31	0	12	4	1.92e-10	1.18e-09
101	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(3), ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ADK(1), ADSL(7), ADSS(2), AK2(1), AK5(5), AK7(6), ALLC(5), AMPD1(9), AMPD2(5), AMPD3(3), ATIC(4), DCK(2), ENPP1(4), ENPP3(4), ENTPD1(2), ENTPD3(5), ENTPD4(5), ENTPD5(2), ENTPD6(2), FHIT(1), GART(3), GMPR(2), GMPR2(2), GMPS(5), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(8), GUCY2D(8), GUCY2F(11), HPRT1(2), IMPDH1(2), IMPDH2(4), ITPA(2), NME6(4), NME7(5), NPR1(6), NPR2(10), NT5C1A(1), NT5C1B(10), NT5C2(4), NT5C3(2), NT5E(3), NT5M(1), NUDT9(2), PAICS(1), PAPSS1(2), PAPSS2(4), PDE10A(11), PDE11A(8), PDE1A(4), PDE1C(9), PDE3B(3), PDE4A(4), PDE4B(5), PDE4C(2), PDE4D(4), PDE5A(6), PDE6D(1), PDE7A(3), PDE7B(4), PDE8A(1), PDE8B(7), PDE9A(6), PFAS(1), PKM2(2), PNPT1(10), POLA1(8), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(21), POLE2(1), POLE3(1), POLR1A(10), POLR1B(8), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(11), POLR3GL(1), POLR3H(1), POLR3K(1), PPAT(6), PRIM2(9), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RFC5(3), RRM1(2), RRM2(2), XDH(7)	55815352	520	118	511	167	167	182	92	3	76	0	3.24e-10	1.98e-09
102	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(2), EIF4A2(5), EIF4B(2), EIF4G1(9), EIF4G2(7), EIF4G3(11), MKNK1(1), PDK2(2), PDPK1(1), PIK3CA(40), PIK3R1(10), PPP2CA(1), PTEN(10), RPS6KB1(3), TSC1(4), TSC2(2)	9244192	110	58	87	23	27	34	29	3	14	3	4.54e-10	2.74e-09
103	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(8), AKT1(2), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CREB1(1), GNAS(6), GRB2(3), MAPK1(2), MAPK14(3), MAPK3(3), PIK3CA(40), PIK3R1(10), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), RPS6KA1(1), RPS6KA5(6), SOS1(7)	9743052	117	68	96	25	33	43	32	0	7	2	6.18e-10	3.70e-09
104	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT1(2), AKT2(6), AKT3(1), CASP8(11), CD14(1), CD40(1), CD80(1), CHUK(6), CXCL10(1), CXCL11(3), CXCL9(3), FOS(1), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNB1(1), IKBKB(4), IKBKE(4), IL12A(1), IL12B(2), IL1B(1), IL6(2), IL8(1), IRAK1(1), IRAK4(4), IRF3(2), IRF5(3), LBP(1), LY96(2), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K4(11), MAP2K6(3), MAP3K7(4), MAP3K8(2), MAPK1(2), MAPK10(8), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK8(7), MAPK9(5), MYD88(2), NFKB1(6), NFKB2(4), PIK3CA(40), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), RELA(2), RIPK1(2), SPP1(1), STAT1(6), TBK1(6), TICAM1(2), TIRAP(1), TLR1(5), TLR2(6), TLR3(5), TLR4(10), TLR5(4), TLR6(2), TLR7(7), TLR8(6), TLR9(7), TOLLIP(1), TRAF3(6), TRAF6(4)	30153592	326	104	304	76	81	119	81	4	38	3	7.52e-10	4.46e-09
105	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(37), BMPR1B(10), CCND2(1), CDK4(3), CDKN1B(3), DAZL(2), DMC1(4), EGR1(3), ESR2(2), FSHR(7), GJA4(2), INHA(2), LHCGR(4), MLH1(8), MSH5(5), NCOR1(12), NRIP1(6), PGR(4), PRLR(4), PTGER2(1), SMPD1(6), VDR(2), ZP2(7)	11680968	135	58	134	34	36	43	28	2	24	2	1.50e-09	8.80e-09
106	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	109	A4GNT(4), ALG1(1), ALG10(3), ALG10B(7), ALG11(1), ALG12(2), ALG13(1), ALG14(1), ALG2(3), ALG3(1), ALG6(3), ALG8(6), ALG9(2), B3GNT1(2), B3GNT2(2), B3GNT7(6), B4GALT1(6), B4GALT2(3), B4GALT3(7), B4GALT5(2), C1GALT1C1(2), CHPF(3), CHST1(7), CHST11(3), CHST12(3), CHST13(2), CHST14(1), CHST2(1), CHST4(7), CHSY1(5), DAD1(2), DDOST(2), DPAGT1(2), EXT1(11), EXTL1(3), EXTL2(6), EXTL3(9), FUT11(1), FUT8(2), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(2), GALNT13(5), GALNT14(10), GALNT2(4), GALNT3(4), GALNT5(10), GALNT6(3), GALNT7(3), GALNT8(2), GALNT9(2), GALNTL1(5), GALNTL2(8), GALNTL4(2), GALNTL5(8), GANAB(4), GCNT1(5), GCNT3(4), GCNT4(7), HS2ST1(4), HS3ST1(2), HS3ST2(3), HS3ST3B1(2), HS3ST5(4), HS6ST2(2), HS6ST3(2), MAN1A1(5), MAN1A2(2), MAN1B1(2), MAN1C1(7), MAN2A1(12), MGAT1(2), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(2), NDST1(4), NDST2(5), NDST3(10), NDST4(4), OGT(5), RPN2(1), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(3), STT3B(6), UST(1), WBSCR17(19), XYLT1(6), XYLT2(2)	37129120	368	105	363	111	139	112	76	3	38	0	3.44e-09	2.00e-08
107	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(4), ANAPC10(2), ANAPC2(1), ANAPC4(4), ANAPC5(3), ANAPC7(4), BTRC(5), CDC16(4), CDC20(3), CDC23(6), CDC27(13), CUL1(8), CUL2(5), CUL3(1), FBXW11(8), FBXW7(45), ITCH(3), RBX1(1), SKP1(1), SKP2(1), SMURF1(3), SMURF2(2), UBA1(2), UBE2C(2), UBE2D1(1), UBE2D3(1), UBE2D4(1), UBE2E1(3), UBE2E2(1), VHL(1), WWP1(8), WWP2(4)	13690328	151	68	129	42	54	41	28	2	26	0	3.78e-09	2.18e-08
108	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(2), AKT2(6), AKT3(1), CDKN1A(1), GRB2(3), MAP2K1(4), MAP2K2(1), NGFR(3), NTRK1(6), PIK3CA(40), PIK3CD(3), SHC1(3), SOS1(7)	5509188	80	53	60	15	17	34	25	0	4	0	4.03e-09	2.30e-08
109	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(2), AKT2(6), AKT3(1), BRAF(23), EIF4B(2), FIGF(2), HIF1A(3), IGF1(2), MAPK1(2), MAPK3(3), PDPK1(1), PGF(2), PIK3CA(40), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PRKAA1(3), PRKAA2(9), RICTOR(13), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA6(7), RPS6KB1(3), RPS6KB2(2), TSC1(4), TSC2(2), ULK1(1), ULK2(4), ULK3(3), VEGFA(2), VEGFB(2), VEGFC(6)	17809656	201	75	160	41	56	60	59	0	24	2	5.54e-09	3.13e-08
110	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(4), AGT(5), AKT1(2), CALR(1), CAMK1(3), CAMK1G(5), CAMK4(3), CREBBP(25), CSNK1A1(2), EDN1(1), ELSPBP1(1), F2(3), GATA4(1), GSK3B(8), HAND1(2), HAND2(2), IGF1(2), MAP2K1(4), MAPK1(2), MAPK14(3), MAPK3(3), MAPK8(7), MEF2C(9), MYH2(12), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NKX2-5(1), NPPA(1), PIK3CA(40), PIK3R1(10), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RAF1(6), RPS6KB1(3), SYT1(1)	16901544	214	81	193	48	71	63	50	1	27	2	6.01e-09	3.37e-08
111	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(4), CRKL(2), DOCK1(7), FOS(1), GAB1(6), GRB2(3), HGF(8), ITGA1(3), ITGB1(6), MAP2K1(4), MAP2K2(1), MAP4K1(3), MAPK1(2), MAPK3(3), MAPK8(7), MET(5), PAK1(5), PIK3CA(40), PIK3R1(10), PTEN(10), PTK2(5), PTK2B(1), PTPN11(5), RAF1(6), RAP1A(2), RAP1B(2), RASA1(9), SOS1(7), SRC(3), STAT3(2)	15249840	172	72	147	33	41	65	44	2	17	3	7.42e-09	4.12e-08
112	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(37), CDC25A(2), CDC25B(5), CDC25C(4), CHEK1(1), MYT1(13), WEE1(3), YWHAH(1)	4676712	66	37	64	7	13	30	10	1	10	2	1.59e-08	8.74e-08
113	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY7(4), ADCY8(12), ADCY9(6), ADORA2A(5), ADORA2B(1), ADRA1A(5), ADRA1B(5), ADRA1D(2), ADRB1(3), ADRB3(1), AGTR1(5), ATP2A1(6), ATP2A2(6), ATP2A3(4), ATP2B1(9), ATP2B2(11), ATP2B3(4), ATP2B4(8), AVPR1A(4), AVPR1B(3), BDKRB2(3), CACNA1A(17), CACNA1B(11), CACNA1C(12), CACNA1D(8), CACNA1E(21), CACNA1F(14), CACNA1G(10), CACNA1H(2), CACNA1I(5), CACNA1S(14), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), CCKAR(2), CCKBR(5), CD38(2), CHRM1(3), CHRM2(11), CHRM3(4), CHRM5(2), CHRNA7(1), CYSLTR1(3), CYSLTR2(4), DRD1(1), EDNRA(4), EDNRB(12), EGFR(11), ERBB2(10), ERBB3(14), ERBB4(21), GNA11(1), GNA14(6), GNA15(3), GNAL(4), GNAQ(4), GNAS(6), GRIN1(1), GRIN2A(21), GRIN2C(4), GRIN2D(5), GRM1(12), GRM5(11), GRPR(3), HRH1(1), HRH2(4), HTR2A(3), HTR2B(1), HTR2C(8), HTR4(3), HTR5A(5), HTR7(7), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), LHCGR(4), MYLK(14), MYLK2(3), NOS1(11), NOS3(2), NTSR1(1), OXTR(3), P2RX1(1), P2RX2(2), P2RX3(2), P2RX4(3), P2RX5(1), P2RX7(3), PDE1A(4), PDE1B(3), PDE1C(9), PDGFRA(17), PDGFRB(6), PHKA1(8), PHKA2(6), PHKB(6), PHKG2(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCD3(2), PLCD4(2), PLCE1(9), PLCG1(4), PLCG2(13), PLCZ1(4), PLN(1), PPID(3), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), PTAFR(1), PTGER3(7), PTGFR(7), PTK2B(1), RYR1(25), RYR2(59), RYR3(42), SLC25A4(1), SLC25A5(1), SLC8A1(13), SLC8A2(4), SLC8A3(7), SPHK1(1), SPHK2(1), TACR1(2), TACR2(1), TACR3(7), TNNC2(1), TRHR(8), TRPC1(6), VDAC1(1), VDAC3(1)	92807760	956	171	939	373	393	298	174	8	79	4	1.63e-08	8.89e-08
114	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	163	ADORA1(8), ADORA2A(5), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(5), ADRA1D(2), ADRA2A(3), ADRB1(3), ADRB3(1), AGTR1(5), AGTR2(5), AVPR1A(4), AVPR1B(3), AVPR2(6), BDKRB2(3), BRS3(3), C3AR1(4), CCBP2(10), CCKAR(2), CCKBR(5), CCR1(5), CCR3(4), CCR4(1), CCR5(1), CCR6(2), CCR7(3), CCR8(4), CCR9(6), CCRL1(5), CHML(5), CHRM1(3), CHRM2(11), CHRM3(4), CHRM4(1), CHRM5(2), CMKLR1(2), CNR1(5), CX3CR1(2), CXCR4(4), DRD1(1), DRD2(5), DRD3(3), DRD5(6), EDNRA(4), EDNRB(12), F2RL1(1), F2RL2(3), FPR1(2), FSHR(7), GALR1(2), GALT(2), GHSR(5), GPR17(1), GPR173(2), GPR174(3), GPR37(7), GPR37L1(3), GPR4(1), GPR50(5), GPR6(6), GPR63(4), GPR77(2), GPR83(1), GPR85(1), GPR87(5), GRPR(3), HCRTR1(1), HCRTR2(1), HRH1(1), HRH2(4), HTR1A(5), HTR1B(5), HTR1D(2), HTR1E(7), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(8), HTR4(3), HTR5A(5), HTR7(7), LHCGR(4), LTB4R(1), MAS1(2), MC3R(1), MC4R(4), MC5R(6), MLNR(3), MTNR1B(3), NMUR1(4), NMUR2(9), NPY1R(4), NPY2R(5), NPY5R(2), NTSR1(1), NTSR2(5), OPN1SW(3), OPN3(1), OPRD1(1), OPRK1(5), OPRM1(3), OR12D3(4), OR1C1(3), OR1F1(2), OR2H1(4), OR5V1(3), OR7A5(3), OR7C1(6), OR8B8(3), OXTR(3), P2RY1(6), P2RY10(7), P2RY12(4), P2RY13(2), P2RY14(6), P2RY2(3), P2RY6(1), PPYR1(4), PTAFR(1), PTGDR(1), PTGER2(1), PTGFR(7), PTGIR(1), RGR(3), RHO(3), RRH(4), SSTR1(5), SSTR2(3), SSTR4(4), SUCNR1(2), TRHR(8)	39964632	482	128	481	166	191	168	87	3	33	0	1.88e-08	1.02e-07
115	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), ARHGAP5(9), CDC42(1), CDH5(2), CLDN10(4), CLDN11(1), CLDN15(1), CLDN16(5), CLDN17(5), CLDN18(2), CLDN19(1), CLDN2(1), CLDN6(2), CLDN7(2), CLDN8(5), CLDN9(1), CTNNA1(12), CTNNA2(12), CTNNA3(9), CTNNB1(12), CTNND1(6), CXCL12(1), CXCR4(4), CYBB(2), ESAM(3), EZR(2), F11R(1), GNAI1(4), GRLF1(12), ICAM1(2), ITGA4(8), ITGAL(8), ITGAM(8), ITGB1(6), ITGB2(5), ITK(11), JAM3(3), MAPK12(2), MAPK13(1), MAPK14(3), MLLT4(6), MMP2(5), MMP9(11), MSN(6), MYL2(1), MYL7(1), MYL9(2), NCF1(1), NCF2(2), NCF4(3), NOX1(1), NOX3(8), OCLN(1), PECAM1(2), PIK3CA(40), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG1(4), PLCG2(13), PRKCA(4), PRKCG(10), PTK2(5), PTK2B(1), PTPN11(5), RAP1A(2), RAP1B(2), RAPGEF3(4), RAPGEF4(7), RASSF5(3), RHOA(5), RHOH(2), ROCK1(15), ROCK2(6), SIPA1(1), TXK(5), VASP(3), VAV1(13), VAV2(4), VAV3(12), VCAM1(9), VCL(2)	42365788	460	121	433	122	175	142	88	2	51	2	1.90e-08	1.02e-07
116	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), ACTR3(3), AKT1(2), ANGPTL2(8), DAG1(5), DGKA(1), ETFA(3), ITGA9(6), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), MAP2K1(4), MAPK1(2), MAPK3(3), NR1I3(3), PAK1(5), PDE3A(5), PDE3B(3), PI3(1), PIK3C2G(9), PIK3CA(40), PIK3CD(3), PIK3R1(10), PLDN(1), RIPK3(4), RPS4X(2), SGCB(4), VASP(3)	16755560	185	78	165	42	57	57	40	3	24	4	3.04e-08	1.62e-07
117	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(2), AKT2(6), AKT3(1), BAD(1), BCL2(1), GRB2(3), GSK3A(2), GSK3B(8), IL4R(1), IRS1(8), JAK1(4), JAK3(8), MAP4K1(3), MAPK1(2), MAPK3(3), PDK1(2), PIK3CA(40), PIK3CD(3), PIK3R1(10), PPP1R13B(6), RAF1(6), SHC1(3), SOS1(7), SOS2(11), STAT6(2)	12259008	143	70	120	26	38	50	34	0	19	2	3.75e-08	1.97e-07
118	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(2), GHR(6), GRB2(3), INSR(6), IRS1(8), JAK2(9), MAP2K1(4), MAPK1(2), MAPK3(3), PIK3CA(40), PIK3R1(10), PLCG1(4), PRKCA(4), PTPN6(4), RAF1(6), RPS6KA1(1), SHC1(3), SLC2A4(4), SOS1(7), SRF(3), STAT5B(3)	11097708	132	66	110	31	37	49	31	0	11	4	5.62e-08	2.93e-07
119	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(5), EIF2B1(2), EIF2B2(1), EIF2B3(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), ELAVL1(3), FLT1(12), FLT4(5), HIF1A(3), KDR(10), NOS3(2), PIK3CA(40), PIK3R1(10), PLCG1(4), PRKCA(4), PTK2(5), SHC1(3), VHL(1)	11338188	119	66	98	29	32	42	29	0	14	2	9.59e-08	4.97e-07
120	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT1(2), AKT2(6), AKT3(1), BAD(1), BTK(7), CDKN2A(1), DAPP1(2), GRB2(3), GSK3A(2), GSK3B(8), IARS(6), IGFBP1(2), INPP5D(4), PDK1(2), PIK3CA(40), PPP1R13B(6), PTEN(10), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), SHC1(3), SOS1(7), SOS2(11), TEC(3), YWHAB(2), YWHAE(3), YWHAH(1), YWHAQ(1)	12160912	153	65	130	30	40	56	39	0	17	1	2.06e-07	1.06e-06
121	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(5), CD28(2), CD3D(1), CSK(3), CTLA4(2), DAG1(5), DTYMK(1), EPHB2(8), FBXW7(45), GRAP2(5), GRB2(3), ITK(11), ITPKB(4), LAT(1), LCK(3), LCP2(3), MAPK1(2), NCK1(1), NFAT5(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PLCG1(4), PTPRC(17), RAF1(6), RASGRP1(5), RASGRP2(7), RASGRP3(7), RASGRP4(2), SOS1(7), SOS2(11), VAV1(13), ZAP70(4)	18849228	227	79	206	59	93	70	36	4	24	0	2.30e-07	1.17e-06
122	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	86	AGRN(1), CD36(1), CD44(3), CD47(3), CHAD(7), COL11A1(24), COL11A2(11), COL1A1(11), COL1A2(16), COL2A1(9), COL3A1(12), COL4A1(14), COL4A2(4), COL4A4(10), COL4A6(15), COL5A1(15), COL5A2(13), COL5A3(10), COL6A2(1), COL6A3(43), COL6A6(20), DAG1(5), FN1(21), FNDC1(23), FNDC3A(7), FNDC4(1), GP1BA(1), GP5(6), GP6(2), HMMR(6), HSPG2(9), IBSP(3), ITGA1(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGAV(5), ITGB1(6), ITGB3(9), ITGB4(3), ITGB5(6), ITGB6(6), ITGB7(4), ITGB8(5), LAMA1(24), LAMA2(25), LAMA3(18), LAMA4(11), LAMB1(8), LAMB2(5), LAMB3(9), LAMB4(16), LAMC1(11), LAMC2(10), LAMC3(8), RELN(33), SDC1(1), SDC2(3), SDC3(3), SDC4(1), SPP1(1), SV2A(5), SV2B(6), SV2C(4), THBS1(10), THBS2(15), THBS3(3), THBS4(2), TNC(16), TNN(17), TNR(21), TNXB(17), VTN(6), VWF(15)	76193716	762	142	754	308	277	267	125	9	83	1	2.61e-07	1.32e-06
123	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	ACOX1(3), APOA2(1), CD36(1), CITED2(1), CPT1B(5), CREBBP(25), DUSP1(2), EHHADH(2), EP300(15), FABP1(1), HSD17B4(3), LPL(6), MAPK1(2), MAPK3(3), ME1(9), NCOA1(8), NCOR1(12), NCOR2(2), NR1H3(4), NR2F1(3), NRIP1(6), PDGFA(1), PIK3CA(40), PIK3R1(10), PPARA(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PTGS2(3), RB1(7), RELA(2), RXRA(1), SP1(2), STAT5B(3)	20895640	201	78	181	55	57	65	49	2	25	3	2.79e-07	1.40e-06
124	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(2), AKT2(6), AKT3(1), BAD(1), BCR(7), BLNK(1), BTK(7), CD19(3), CSK(3), DAG1(5), EPHB2(8), GRB2(3), ITPKB(4), LYN(4), MAP2K1(4), MAP2K2(1), MAPK1(2), NFAT5(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PI3(1), PIK3CA(40), PIK3CD(3), PIK3R1(10), PLCG2(13), PPP1R13B(6), RAF1(6), SERPINA4(5), SHC1(3), SOS1(7), SOS2(11), SYK(3), VAV1(13)	17545152	201	81	176	41	71	63	45	2	18	2	3.01e-07	1.49e-06
125	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(4), AK3(1), CAD(11), CDA(1), CTPS(4), CTPS2(4), DCK(2), DCTD(3), DHODH(4), DPYD(14), DPYS(7), DTYMK(1), ENTPD1(2), ENTPD3(5), ENTPD4(5), ENTPD5(2), ENTPD6(2), ITPA(2), NME6(4), NME7(5), NT5C1A(1), NT5C1B(10), NT5C2(4), NT5C3(2), NT5E(3), NT5M(1), PNPT1(10), POLA1(8), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(21), POLE2(1), POLE3(1), POLR1A(10), POLR1B(8), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(11), POLR3GL(1), POLR3H(1), POLR3K(1), PRIM2(9), RFC5(3), RRM1(2), RRM2(2), TK1(1), TK2(1), TXNRD1(3), TXNRD2(3), TYMS(3), UCK2(1), UMPS(1), UPB1(5), UPP2(2), UPRT(4)	27725384	261	85	256	62	73	97	55	1	35	0	3.88e-07	1.91e-06
126	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), ACTR3(3), AKT1(2), AKT2(6), AKT3(1), ANGPTL2(8), ARHGAP4(1), ARHGEF11(11), BTK(7), CDC42(1), CFL1(1), GDI1(1), GDI2(1), INPPL1(4), ITPR1(19), ITPR2(18), ITPR3(12), LIMK1(5), MYLK(14), MYLK2(3), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PDK1(2), PIK3CA(40), PIK3CD(3), PIK3CG(14), PIK3R1(10), PITX2(2), PPP1R13B(6), PTEN(10), RACGAP1(2), RHO(3), ROCK1(15), ROCK2(6), RPS4X(2), SAG(1), WASF1(3), WASL(7)	23949792	267	89	245	63	88	90	50	1	34	4	4.42e-07	2.16e-06
127	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ADRA1A(5), ADRA1B(5), ADRA1D(2), ADRB1(3), ADRB3(1), ANXA6(3), ARRB1(1), ATP1A4(8), ATP1B1(1), ATP1B2(2), ATP2A2(6), ATP2A3(4), ATP2B1(9), ATP2B2(11), ATP2B3(4), CACNA1A(17), CACNA1B(11), CACNA1C(12), CACNA1D(8), CACNA1E(21), CACNA1S(14), CACNB1(1), CACNB3(2), CALR(1), CAMK1(3), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), CASQ1(2), CASQ2(4), CHRM1(3), CHRM2(11), CHRM3(4), CHRM4(1), CHRM5(2), GJA1(7), GJA4(2), GJA5(3), GJB1(3), GJB3(4), GJB4(1), GNA11(1), GNAO1(5), GNAQ(4), GNAZ(1), GNB1(1), GNB3(3), GNB4(3), GNB5(1), GNG3(2), GNG4(1), GNG7(1), GNGT1(1), GRK4(5), GRK5(4), GRK6(3), ITPR1(19), ITPR2(18), ITPR3(12), KCNB1(5), KCNJ3(6), KCNJ5(4), MIB1(3), MYCBP(1), NME7(5), PEA15(1), PKIA(1), PKIB(1), PLCB3(4), PLN(1), PRKACA(1), PRKACB(1), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCQ(5), PRKD1(15), RGS1(1), RGS10(1), RGS14(2), RGS16(2), RGS17(2), RGS18(2), RGS2(3), RGS20(4), RGS3(10), RGS4(3), RGS5(1), RGS6(3), RGS7(6), RGS9(7), RYR1(25), RYR2(59), RYR3(42), SLC8A1(13), SLC8A3(7), USP5(4), YWHAB(2), YWHAH(1), YWHAQ(1)	65101364	656	142	652	268	282	211	105	1	55	2	6.72e-07	3.26e-06
128	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(4), ACVR1B(15), ACVRL1(4), AKT1(2), AURKB(1), BMPR1A(4), BMPR2(10), BUB1(6), CDKL1(4), CDKL2(4), CDS1(2), CDS2(4), CLK1(6), CLK4(2), COL4A3BP(3), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKZ(3), IMPA1(2), INPP1(2), INPP4A(3), INPP4B(7), INPP5A(2), INPPL1(4), ITPKB(4), MAP3K10(3), MOS(3), NEK1(9), NEK3(4), OCRL(9), PIK3C2A(5), PIK3C2B(8), PIK3C2G(9), PIK3CA(40), PIK3CB(2), PIK3CG(14), PIM2(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCG1(4), PLCG2(13), PLK3(2), PRKACA(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCQ(5), PRKD1(15), PRKG1(9), RAF1(6), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), TGFBR1(9), VRK1(4)	38667092	409	118	384	105	150	137	85	2	35	0	1.07e-06	5.16e-06
129	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(11), GABRA1(4), GABRA2(9), GABRA3(5), GABRA4(8), GABRA5(9), GABRA6(5), GPHN(12), NSF(1), SRC(3), UBQLN1(2)	4059556	69	38	65	22	19	31	11	0	8	0	1.21e-06	5.79e-06
130	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	137	ACTB(2), CHAD(7), COL11A1(24), COL11A2(11), COL17A1(8), COL1A1(11), COL1A2(16), COL2A1(9), COL3A1(12), COL4A1(14), COL4A2(4), COL4A4(10), COL4A6(15), COL5A1(15), COL5A2(13), COL5A3(10), COL6A2(1), COL6A3(43), COL6A6(20), COMP(2), DES(1), DSC1(8), DSC2(2), DSC3(4), DSG1(8), DSG2(5), DSG3(8), DSG4(9), FN1(21), GJA1(7), GJA10(9), GJA4(2), GJA5(3), GJA8(5), GJA9(4), GJB1(3), GJB3(4), GJB4(1), GJB7(2), GJC1(4), GJC2(1), GJC3(2), GJD2(1), GJD4(2), IBSP(3), INA(2), ITGA6(4), ITGB4(3), KRT1(4), KRT10(2), KRT12(2), KRT13(4), KRT14(2), KRT15(2), KRT16(2), KRT17(2), KRT18(2), KRT19(2), KRT2(1), KRT20(1), KRT23(1), KRT24(3), KRT25(3), KRT27(2), KRT28(1), KRT3(6), KRT31(4), KRT32(2), KRT33A(2), KRT33B(5), KRT34(4), KRT35(3), KRT36(2), KRT37(6), KRT38(2), KRT4(2), KRT5(4), KRT6A(4), KRT6B(2), KRT6C(2), KRT7(3), KRT71(3), KRT72(5), KRT73(4), KRT74(4), KRT75(6), KRT76(2), KRT77(1), KRT78(4), KRT79(3), KRT8(1), KRT81(1), KRT82(6), KRT83(1), KRT84(9), KRT85(6), KRT9(5), LAMA1(24), LAMA2(25), LAMA3(18), LAMA4(11), LAMB1(8), LAMB2(5), LAMB3(9), LAMB4(16), LAMC1(11), LAMC2(10), LAMC3(8), LMNB1(4), LMNB2(1), NES(7), PRPH(2), RELN(33), SPP1(1), THBS1(10), THBS2(15), THBS3(3), THBS4(2), TNC(16), TNN(17), TNR(21), TNXB(17), VIM(3), VTN(6), VWF(15)	83189744	843	151	836	335	335	295	123	10	79	1	1.65e-06	7.84e-06
131	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(3), BFAR(1), BRAF(23), CREB1(1), CREB3(3), CREB5(4), MAPK1(2), RAF1(6), SNX13(9), SRC(3), TERF2IP(2)	3934428	57	37	37	12	12	9	30	1	5	0	2.73e-06	0.000013
132	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(2), AKT2(6), AKT3(1), BRD4(4), CAP1(1), CBL(5), CDC42(1), CDKN2A(1), F2RL2(3), FLOT1(3), GRB2(3), GSK3A(2), GSK3B(8), IGFBP1(2), INPPL1(4), IRS1(8), IRS4(15), LNPEP(8), MAPK1(2), MAPK3(3), PARD3(7), PARD6A(2), PDK1(2), PIK3CA(40), PIK3CD(3), PIK3R1(10), PPYR1(4), PTEN(10), PTPN1(5), RAF1(6), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), SERPINB6(2), SHC1(3), SLC2A4(4), SORBS1(11), SOS1(7), SOS2(11), YWHAB(2), YWHAE(3), YWHAH(1), YWHAQ(1)	19702648	235	80	209	54	73	81	49	3	26	3	3.21e-06	0.000015
133	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(2), CABIN1(11), CAMK1(3), CAMK1G(5), HDAC5(2), IGF1(2), IGF1R(8), INSR(6), MAP2K6(3), MAPK14(3), MAPK7(3), MEF2A(4), MEF2C(9), MEF2D(1), NFATC1(2), NFATC2(5), PIK3CA(40), PIK3R1(10), PPP3CA(3), PPP3CB(5), PPP3CC(4), SYT1(1), YWHAH(1)	11635156	133	67	112	40	47	41	27	0	16	2	3.62e-06	0.000017
134	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(2), BAD(1), BCL2(1), BCL2L1(1), CBL(5), CFLAR(3), CRKL(2), FOS(1), GRB2(3), IL2RA(2), IL2RB(2), IRS1(8), JAK1(4), JAK3(8), MAPK1(2), MAPK3(3), NMI(2), PIK3CA(40), PIK3R1(10), PTPN6(4), RAF1(6), RPS6KB1(3), SHC1(3), SOS1(7), STAT5B(3), SYK(3)	12114876	129	64	106	31	35	51	26	0	15	2	4.19e-06	0.000019
135	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(2), INPP1(2), INPP4A(3), INPP4B(7), INPP5A(2), INPPL1(4), ITPKB(4), MIOX(1), OCRL(9), PIK3C2A(5), PIK3C2B(8), PIK3C2G(9), PIK3CA(40), PIK3CB(2), PIK3CG(14), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCG1(4), PLCG2(13)	15298112	161	74	140	35	56	58	35	1	11	0	4.70e-06	0.000021
136	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(2), AKT2(6), AKT3(1), BAD(1), BCL2(1), BCR(7), BLNK(1), BTK(7), CD19(3), CD22(10), CR2(11), CSK(3), DAG1(5), FLOT1(3), GRB2(3), GSK3A(2), GSK3B(8), INPP5D(4), ITPR1(19), ITPR2(18), ITPR3(12), LYN(4), MAP4K1(3), MAPK1(2), MAPK3(3), NFATC1(2), NFATC2(5), PDK1(2), PIK3CA(40), PIK3CD(3), PIK3R1(10), PLCG2(13), PPP1R13B(6), PPP3CA(3), PPP3CB(5), PPP3CC(4), PTPRC(17), RAF1(6), SHC1(3), SOS1(7), SOS2(11), SYK(3), VAV1(13)	24916744	292	88	267	59	102	95	54	2	36	3	5.42e-06	0.000025
137	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(4), GABRA2(9), GABRA3(5), GABRA4(8), GABRA5(9), GABRA6(5), GPX1(1), PRKCE(6)	2668600	47	28	45	8	14	22	6	0	5	0	7.03e-06	0.000032
138	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(7), ERBB4(21), NRG2(6), NRG3(7), PRKCA(4), PSEN1(3)	3031616	48	31	47	9	11	19	9	2	7	0	0.000014	0.000062
139	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(2), AKT2(6), AKT3(1), BAD(1), BCL2L1(1), CDC42(1), CDK2(2), CDKN1B(3), CDKN2A(1), CREB1(1), CREB3(3), CREB5(4), EBP(2), ERBB4(21), F2RL2(3), GAB1(6), GRB2(3), GSK3A(2), GSK3B(8), IGF1(2), IGFBP1(2), INPPL1(4), IRS1(8), IRS4(15), MET(5), NOLC1(8), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PARD3(7), PARD6A(2), PDK1(2), PIK3CA(40), PIK3CD(3), PPP1R13B(6), PREX1(16), PTEN(10), PTK2(5), PTPN1(5), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), SHC1(3), SLC2A4(4), SOS1(7), SOS2(11), TSC1(4), TSC2(2), YWHAB(2), YWHAE(3), YWHAH(1), YWHAQ(1)	25655592	289	88	265	87	85	105	58	4	36	1	0.000015	0.000066
140	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(2), AKT2(6), AKT3(1), GRB2(3), IARS(6), IL13RA1(2), IL4(3), IL4R(1), INPP5D(4), JAK1(4), JAK2(9), JAK3(8), PI3(1), PIK3CA(40), PPP1R13B(6), RPS6KB1(3), SERPINA4(5), SHC1(3), SOS1(7), SOS2(11), SRC(3), STAT6(2), TYK2(1)	12514644	131	65	109	32	32	53	30	1	13	2	0.000015	0.000067
141	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(4), ACTA2(3), ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ADM(2), ARRB1(1), ATF1(2), ATF2(1), ATF3(1), ATF4(1), ATP2A2(6), ATP2A3(4), CACNB3(2), CALCA(4), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CNN1(1), CNN2(1), CORIN(13), CREB3(3), CRHR1(2), DGKZ(3), ETS2(3), FOS(1), GABPA(4), GABPB2(3), GBA2(5), GJA1(7), GNAQ(4), GNB1(1), GNB3(3), GNB4(3), GNB5(1), GNG3(2), GNG4(1), GNG7(1), GNGT1(1), GRK4(5), GRK5(4), GRK6(3), GSTO1(1), GUCA2B(2), GUCY1A3(17), IGFBP1(2), IGFBP2(1), IGFBP3(4), IGFBP4(2), IL1B(1), IL6(2), ITPR1(19), ITPR2(18), ITPR3(12), MIB1(3), MYL2(1), MYL4(1), MYLK2(3), NFKB1(6), NOS1(11), NOS3(2), OXTR(3), PDE4B(5), PDE4D(4), PKIA(1), PKIB(1), PLCB3(4), PLCD1(7), PLCG1(4), PLCG2(13), PRKACA(1), PRKACB(1), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PRKCD(3), PRKCE(6), PRKCH(3), PRKCQ(5), PRKD1(15), RAMP1(1), RAMP3(4), RGS1(1), RGS10(1), RGS14(2), RGS16(2), RGS17(2), RGS18(2), RGS2(3), RGS20(4), RGS3(10), RGS4(3), RGS5(1), RGS6(3), RGS7(6), RGS9(7), RLN1(1), RYR1(25), RYR2(59), RYR3(42), SLC8A1(13), SP1(2), TNXB(17), USP5(4), YWHAB(2), YWHAH(1), YWHAQ(1)	58926980	598	133	591	212	244	201	92	2	58	1	0.000015	0.000067
142	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QB(1), C1R(3), C1S(6), C2(4), C3(11), C5(13), C6(13), C7(5), C8A(6), C8B(10), C9(5), MASP1(12)	7056500	89	45	89	26	29	32	16	0	11	1	0.000017	0.000075
143	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(3), EGFR(11), ERBB3(14), NRG1(15), UBE2D1(1)	3454440	44	33	40	7	18	8	11	1	6	0	0.000022	0.000095
144	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(11), BDKRB2(3), C1QB(1), C1QC(3), C1R(3), C1S(6), C2(4), C3(11), C3AR1(4), C4BPA(7), C5(13), C5AR1(3), C6(13), C7(5), C8A(6), C8B(10), C9(5), CD46(3), CD55(4), CFB(4), CFH(16), CFI(2), CPB2(2), CR1(10), CR2(11), F10(1), F11(4), F12(2), F13A1(10), F13B(5), F2(3), F3(2), F5(21), F7(3), F8(18), F9(6), FGA(13), FGB(2), FGG(4), KLKB1(6), KNG1(4), MASP1(12), MASP2(4), PLAT(5), PLAU(3), PLAUR(4), PLG(9), PROC(1), PROS1(6), SERPINA1(3), SERPINA5(4), SERPINC1(3), SERPIND1(2), SERPINE1(3), SERPING1(5), TFPI(3), THBD(2), VWF(15)	30453228	348	97	343	111	97	142	69	0	39	1	0.000023	0.000097
145	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(6), CALR(1), CANX(2), CD4(2), CD74(1), CD8B(2), CIITA(7), CREB1(1), CTSB(5), CTSL1(4), CTSS(2), HLA-A(3), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DMB(1), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(1), HLA-DRA(5), HLA-DRB1(2), HLA-DRB5(1), HLA-E(1), HLA-F(2), HLA-G(2), HSP90AA1(3), HSP90AB1(3), HSPA5(1), IFI30(1), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), KIR2DL1(2), KIR2DL3(1), KIR2DL4(2), KIR3DL1(4), KIR3DL2(4), KIR3DL3(4), KLRC3(3), KLRC4(1), KLRD1(1), LGMN(3), NFYA(3), NFYB(1), NFYC(3), PDIA3(2), RFX5(1), RFXAP(1), TAP1(5), TAP2(5), TAPBP(5)	14976616	149	53	145	42	28	61	29	2	22	7	0.000023	0.000097
146	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(4), ACTN1(5), ACTR2(2), ACTR3(3), AKT1(2), AKT2(6), AKT3(1), ANGPTL2(8), ARHGEF6(10), ARHGEF7(8), BRAF(23), CAV1(1), CDC42(1), CDKN2A(1), CSE1L(4), DOCK1(7), EPHB2(8), FYN(5), GRB2(3), GRB7(1), GRLF1(12), ITGA1(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGB3BP(3), MAP2K4(11), MAP3K11(4), MAPK1(2), MAPK10(8), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), MRAS(1), MYLK(14), MYLK2(3), P4HB(2), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PIK3CA(40), PIK3CB(2), PLCG1(4), PLCG2(13), PTEN(10), PTK2(5), RAF1(6), RALA(1), RHO(3), ROCK1(15), ROCK2(6), SHC1(3), SOS1(7), SOS2(11), SRC(3), TERF2IP(2), TLN1(7), TLN2(8), VASP(3), WAS(1), ZYX(1)	41441556	414	111	364	130	129	129	98	5	52	1	0.000038	0.00016
147	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(9), ARHGEF1(5), GNA12(2), GNA13(2), GNAQ(4), GNB1(1), GNGT1(1), MYL2(1), MYLK(14), PLCB1(8), PPP1R12B(9), PRKCA(4), ROCK1(15)	7003500	75	40	73	19	19	22	15	2	17	0	0.000049	0.00021
148	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(26), MAP2(25), PPP2CA(1), PRKACB(1), PRKACG(3), PRKAG1(1), PRKAR2B(3), PRKCE(6)	6152068	66	37	64	20	18	23	13	0	12	0	0.000070	0.00029
149	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(5), AGTR2(5), ATP8A1(10), AVPR1A(4), AVPR1B(3), AVPR2(6), BDKRB2(3), BRS3(3), C3AR1(4), CCKAR(2), CCKBR(5), CCR1(5), CCR3(4), CCR4(1), CCR5(1), CCR6(2), CCR7(3), CCR8(4), CX3CR1(2), CXCR4(4), EDNRA(4), EDNRB(12), FPR1(2), FSHR(7), GALR1(2), GALT(2), GHSR(5), GNRHR(4), GPR77(2), GRPR(3), LHCGR(4), MC2R(5), MC3R(1), MC4R(4), MC5R(6), NPY1R(4), NPY2R(5), NPY5R(2), NTSR1(1), NTSR2(5), OPRD1(1), OPRK1(5), OPRM1(3), OXTR(3), PPYR1(4), SSTR1(5), SSTR2(3), SSTR4(4), TAC4(1), TACR1(2), TACR2(1), TACR3(7), TRHR(8), TSHR(7)	17087944	210	80	209	82	80	70	48	1	11	0	0.000089	0.00037
150	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), ATF1(2), CDC42(1), CREB1(1), CREB3(3), CREB5(4), DUSP1(2), DUSP10(5), EEF2K(1), IL1R1(4), MAP2K3(6), MAP2K4(11), MAP2K6(3), MAP3K10(3), MAP3K4(18), MAP3K5(6), MAP3K7(4), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPKAPK2(3), MAPKAPK5(1), MKNK1(1), MKNK2(3), MYEF2(7), NFKB1(6), NR2C2(4), SRF(3), TRAF6(4)	11329396	116	54	114	27	37	36	23	3	17	0	0.00010	0.00041
151	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5R1(1), DAB1(7), FYN(5), LRP8(4), RELN(33), VLDLR(5)	4690340	55	33	53	19	14	21	12	1	7	0	0.00010	0.00041
152	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(2), C1GALT1C1(2), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(2), GALNT13(5), GALNT14(10), GALNT2(4), GALNT3(4), GALNT5(10), GALNT6(3), GALNT7(3), GALNT8(2), GALNT9(2), GALNTL1(5), GALNTL2(8), GALNTL4(2), GALNTL5(8), GCNT1(5), GCNT3(4), GCNT4(7), OGT(5), ST3GAL1(1), ST3GAL2(1), ST6GALNAC1(3), WBSCR17(19)	10888664	128	56	126	31	47	46	18	0	17	0	0.00014	0.00056
153	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(2), BAD(1), BRAF(23), CREB1(1), CREB3(3), CREB5(4), DUSP4(1), DUSP6(5), DUSP9(1), EEF2K(1), GRB2(3), MAP2K1(4), MAP2K2(1), MAP3K8(2), MAPK1(2), MAPK3(3), MKNK1(1), MKNK2(3), MOS(3), NFKB1(6), RAP1A(2), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), SHC1(3), SOS1(7), SOS2(11), TRAF3(6)	10079380	115	54	95	23	28	32	39	2	14	0	0.00016	0.00063
154	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(4), CFL1(1), GNAQ(4), GNAS(6), GNB1(1), GNGT1(1), LIMK1(5), MAP2K1(4), MAPK1(2), MAPK3(3), MYL2(1), NOX1(1), PIK3C2G(9), PLCB1(8), PPP1R12B(9), PRKCA(4), PTK2(5), RAF1(6), ROCK2(6)	8616952	80	47	78	16	30	21	13	1	15	0	0.00017	0.00068
155	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(42), B3GALT4(1), CDR1(2), DGKI(10), FAU(1), IL6ST(3), MRPL19(1), PIGK(4), RPL10(1), RPL11(1), RPL18A(1), RPL19(1), RPL21(1), RPL22(2), RPL24(1), RPL28(2), RPL3(2), RPL31(2), RPL32(1), RPL35(1), RPL39(1), RPL3L(1), RPL4(2), RPL5(1), RPL6(3), RPL7(1), RPL9(4), RPLP0(2), RPS11(1), RPS13(1), RPS16(2), RPS18(2), RPS2(1), RPS20(1), RPS23(4), RPS3(2), RPS4X(2), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA6(7), RPS6KB1(3), RPS6KB2(2), RPS9(2), RPSA(1), SLC36A2(2), TBC1D10C(2), TSPAN9(2), UBA52(2), UBB(2)	17685824	152	66	150	39	52	43	31	3	23	0	0.00017	0.00069
156	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(3), AKR1D1(1), ARSD(3), ARSE(2), CARM1(2), CYP11B1(9), CYP11B2(5), CYP19A1(8), HSD11B1(1), HSD17B12(2), HSD17B2(2), HSD17B3(2), HSD17B8(1), HSD3B1(3), HSD3B2(1), LCMT1(3), LCMT2(2), METTL2B(2), METTL6(8), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), SRD5A1(1), SRD5A2(2), STS(7), SULT1E1(2), SULT2A1(2), SULT2B1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A1(8), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6), WBSCR22(1)	16184364	152	62	149	33	44	53	30	2	23	0	0.00021	0.00081
157	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(3), ARHGAP4(1), ARHGAP5(9), ARHGAP6(2), ARHGEF1(5), ARHGEF11(11), ARHGEF5(7), ARPC1A(5), ARPC1B(2), ARPC2(2), BAIAP2(1), CFL1(1), DIAPH1(1), LIMK1(5), MYL2(1), MYLK(14), OPHN1(7), PIP5K1A(3), PIP5K1B(2), PPP1R12B(9), ROCK1(15), SRC(3), TLN1(7), VCL(2)	15703444	120	61	118	36	40	32	24	2	22	0	0.00022	0.00086
158	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(11), C5(13), C6(13), C7(5), C8A(6), C9(5)	4331412	53	30	53	14	16	19	10	0	7	1	0.00023	0.00090
159	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(8), CREM(4), FHL5(4), FSHB(2), FSHR(7), GNAS(6), XPO1(2)	3165356	33	29	33	12	13	9	7	1	3	0	0.00024	0.00095
160	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(1), ADAM17(7), ATP6AP1(2), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(9), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), CASP3(2), CDC42(1), CHUK(6), CSK(3), EGFR(11), F11R(1), GIT1(3), HBEGF(1), IGSF5(8), IKBKB(4), IL8(1), JAM3(3), LYN(4), MAP2K4(11), MAP3K14(3), MAPK10(8), MAPK12(2), MAPK13(1), MAPK14(3), MAPK8(7), MAPK9(5), MET(5), NFKB1(6), NFKB2(4), NOD1(4), PAK1(5), PLCG1(4), PLCG2(13), PTPN11(5), PTPRZ1(17), RELA(2), SRC(3), TCIRG1(2), TJP1(7)	23825388	223	75	219	52	78	68	49	2	25	1	0.00026	0.00098
161	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), BAX(1), BCL2(1), CASP8(11), MAP2K1(4), MAP2K4(11), MAP3K1(8), MAPK1(2), MAPK3(3), MAPK8(7), NFKB1(6), NSMAF(3), RAF1(6), RELA(2), RIPK1(2), SMPD1(6), TNFRSF1A(1), TRADD(1), TRAF2(1)	6963064	77	43	74	18	29	21	15	2	10	0	0.00026	0.00100
162	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(2), AKT2(6), AKT3(1), BCR(7), BTK(7), CD19(3), CDKN2A(1), DAPP1(2), FLOT1(3), GAB1(6), ITPR1(19), ITPR2(18), ITPR3(12), LYN(4), PDK1(2), PHF11(2), PIK3CA(40), PITX2(2), PLCG2(13), PPP1R13B(6), PREX1(16), PTEN(10), PTPRC(17), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), SAG(1), SYK(3), TEC(3), VAV1(13)	18823120	238	75	214	58	81	80	46	2	27	2	0.00041	0.0015
163	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(8), CD3D(1), CD3G(2), CD4(2), CREBBP(25), CSK(3), GNAS(6), GNB1(1), GNGT1(1), HLA-DRA(5), HLA-DRB1(2), LCK(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PTPRC(17), ZAP70(4)	7622744	93	44	93	25	33	28	18	0	12	2	0.00052	0.0019
164	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(8), CD3D(1), CD3G(2), CD4(2), CREBBP(25), CSK(3), GNAS(6), GNB1(1), GNGT1(1), HLA-DRA(5), HLA-DRB1(2), LCK(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PTPRC(17), ZAP70(4)	7622744	93	44	93	25	33	28	18	0	12	2	0.00052	0.0019
165	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(8), ARHGAP5(9), ARHGDIB(3), CASP1(2), CASP10(2), CASP3(2), CASP8(11), CASP9(2), GZMB(2)	4327428	41	30	39	10	5	14	10	0	12	0	0.00071	0.0027
166	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QB(1), C1R(3), C1S(6), C2(4), C3(11), C5(13), C6(13), C7(5), C8A(6), C9(5), MASP1(12), MASP2(4)	7255088	83	41	83	28	26	29	16	0	11	1	0.00084	0.0031
167	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CDS1(2), CDS2(4), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKI(10), DGKZ(3), IMPA1(2), IMPA2(2), INPP1(2), INPP4A(3), INPP4B(7), INPP5A(2), INPP5B(1), INPP5D(4), INPPL1(4), ITGB1BP3(1), ITPK1(2), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), OCRL(9), PI4KA(15), PI4KB(2), PIK3C2A(5), PIK3C2B(8), PIK3C2G(9), PIK3C3(7), PIK3CA(40), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(4), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCD3(2), PLCD4(2), PLCE1(9), PLCG1(4), PLCG2(13), PLCZ1(4), PRKCA(4), PRKCG(10), PTEN(10), PTPMT1(2), SYNJ1(11), SYNJ2(6)	42786016	395	108	368	104	152	117	77	2	43	4	0.00088	0.0032
168	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(2), IMPA2(2), INPP1(2), INPP4A(3), INPP4B(7), INPP5A(2), INPP5B(1), INPPL1(4), IPMK(2), ITGB1BP3(1), ITPK1(2), ITPKB(4), MINPP1(1), MIOX(1), OCRL(9), PI4KA(15), PI4KB(2), PIK3C3(7), PIK3CA(40), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(4), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCD3(2), PLCD4(2), PLCE1(9), PLCG1(4), PLCG2(13), PLCZ1(4), PTEN(10), PTPMT1(2), SYNJ1(11), SYNJ2(6)	25193288	237	79	212	56	84	73	51	2	25	2	0.00097	0.0036
169	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(2), GALNT10(5), GALNT2(4), GALNT3(4), GALNT6(3), GALNT7(3), GALNT8(2), GALNT9(2), GCNT1(5), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), WBSCR17(19)	4838004	53	33	52	17	23	14	7	0	9	0	0.0011	0.0041
170	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(13), AR(6), ESR1(12), ESR2(2), ESRRA(3), HNF4A(6), NPM1(1), NR0B1(3), NR1D1(4), NR1D2(6), NR1H3(4), NR1I2(2), NR1I3(3), NR2C2(4), NR2E1(2), NR2F1(3), NR2F2(5), NR2F6(1), NR3C1(4), NR4A1(2), NR4A2(7), NR5A2(4), PGR(4), PPARA(1), PPARD(2), PPARG(1), RARB(9), RARG(5), ROR1(9), RORA(2), RORC(1), RXRA(1), RXRB(3), RXRG(4), THRA(2), THRB(4), VDR(2)	14048324	147	66	145	53	56	46	28	3	14	0	0.0013	0.0046
171	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(2), ARHGEF2(5), ARPC5(1), ARPC5L(2), CD14(1), CDC42(1), CDH1(5), CTNNB1(12), CTTN(1), EZR(2), FYN(5), HCLS1(8), ITGB1(6), KRT18(2), LY96(2), NCK1(1), NCL(3), OCLN(1), PRKCA(4), RHOA(5), ROCK1(15), ROCK2(6), TLR4(10), TLR5(4), TUBA1B(2), TUBA1C(2), TUBA3C(9), TUBA3D(3), TUBA3E(5), TUBA4A(3), TUBA8(2), TUBAL3(4), TUBB(1), TUBB1(2), TUBB2A(3), TUBB2B(3), TUBB3(2), TUBB4(3), TUBB4Q(2), TUBB6(3), TUBB8(3), WAS(1), WASL(7), YWHAQ(1)	17464264	169	63	167	54	61	58	29	2	19	0	0.0013	0.0047
172	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(2), ARHGEF2(5), ARPC5(1), ARPC5L(2), CD14(1), CDC42(1), CDH1(5), CTNNB1(12), CTTN(1), EZR(2), FYN(5), HCLS1(8), ITGB1(6), KRT18(2), LY96(2), NCK1(1), NCL(3), OCLN(1), PRKCA(4), RHOA(5), ROCK1(15), ROCK2(6), TLR4(10), TLR5(4), TUBA1B(2), TUBA1C(2), TUBA3C(9), TUBA3D(3), TUBA3E(5), TUBA4A(3), TUBA8(2), TUBAL3(4), TUBB(1), TUBB1(2), TUBB2A(3), TUBB2B(3), TUBB3(2), TUBB4(3), TUBB4Q(2), TUBB6(3), TUBB8(3), WAS(1), WASL(7), YWHAQ(1)	17464264	169	63	167	54	61	58	29	2	19	0	0.0013	0.0047
173	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP3(2), CASP8(11), CFL1(1), CFLAR(3), PDE6D(1)	1284644	19	17	18	2	3	7	5	0	4	0	0.0013	0.0047
174	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(2), BAD(1), BCL2(1), CABIN1(11), CAMK2B(2), CAMK4(3), CD3G(2), CD69(1), CDKN1A(1), CNR1(5), CREBBP(25), CSNK2A1(4), CSNK2B(2), CTLA4(2), EGR2(8), EGR3(2), EP300(15), FCER1A(3), FCGR3A(1), FOS(1), GATA3(4), GATA4(1), GRLF1(12), GSK3A(2), GSK3B(8), ICOS(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(2), IL13(1), IL1B(1), IL2(4), IL2RA(2), IL3(3), IL4(3), IL6(2), IL8(1), ITK(11), KPNA5(4), MAPK14(3), MAPK8(7), MAPK9(5), MEF2A(4), MEF2D(1), MYF5(4), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB2(4), NFKBIB(1), NFKBIE(2), NPPB(1), NUP214(6), OPRD1(1), P2RX7(3), PAK1(5), PIN1(1), PPP3CB(5), PPP3CC(4), PPP3R1(1), PTPRC(17), RELA(2), SLA(4), SP1(2), SP3(3), TGFB1(1), TRAF2(1), TRPV6(11), VAV1(13), VAV2(4), VAV3(12), XPO5(1)	30577832	308	81	304	100	113	90	62	4	39	0	0.0013	0.0048
175	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(3), BHMT(5), CBS(3), CTH(2), DNMT1(19), DNMT3A(9), DNMT3B(8), MARS(6), MARS2(1), MAT1A(5), MAT2B(3), MTR(7)	5898820	71	38	66	15	34	18	6	3	10	0	0.0015	0.0052
176	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(7), GABBR1(6), GPRC5A(2), GPRC5B(2), GPRC5C(2), GPRC5D(1), GRM1(12), GRM2(4), GRM3(7), GRM4(7), GRM5(11), GRM7(12), GRM8(9)	6796908	82	48	80	47	35	23	14	1	9	0	0.0016	0.0055
177	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	CRKL(2), GNAQ(4), GRB2(3), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K4(11), MAP3K1(8), MAPK1(2), MAPK14(3), MAPK3(3), MAPK8(7), PAK1(5), PLCG1(4), PRKCA(4), PTK2B(1), RAF1(6), SHC1(3), SOS1(7), SRC(3), SYT1(1)	9614552	88	46	85	25	23	31	19	4	11	0	0.0017	0.0058
178	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(5), ADRA1B(5), ADRA1D(2), ADRA2A(3), ADRB1(3), ADRB3(1), CHRM1(3), CHRM2(11), CHRM3(4), CHRM4(1), CHRM5(2), DRD1(1), DRD2(5), DRD3(3), DRD5(6), HRH1(1), HRH2(4), HTR1A(5), HTR1B(5), HTR1D(2), HTR1E(7), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(8), HTR4(3), HTR5A(5), HTR7(7)	8529760	108	55	107	45	50	34	13	1	10	0	0.0017	0.0059
179	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(9), AGT(5), AGTR1(5), AGTR2(5), COL4A1(14), COL4A2(4), COL4A3(4), COL4A4(10), COL4A5(19), COL4A6(15), REN(5)	8745596	95	43	94	19	22	33	22	1	17	0	0.0018	0.0060
180	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(4), HLA-DRA(5), HLA-DRB1(2), IL3(3)	943012	14	12	13	4	7	5	0	0	0	2	0.0018	0.0063
181	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(25), EP300(15), ESR1(12), MAPK1(2), MAPK3(3), PELP1(2), SRC(3)	5111820	62	37	62	15	21	16	15	2	8	0	0.0021	0.0070
182	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(11), EXTL1(3), EXTL2(6), EXTL3(9), GLCE(6), HS2ST1(4), HS3ST1(2), HS3ST2(3), HS3ST3B1(2), HS3ST5(4), HS6ST2(2), HS6ST3(2), NDST1(4), NDST2(5), NDST3(10), NDST4(4)	7050708	77	45	76	25	31	21	18	1	6	0	0.0022	0.0075
183	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(4), BMPR1A(4), BMPR1B(10), BMPR2(10)	2094716	28	18	28	5	6	7	8	0	7	0	0.0024	0.0082
184	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(5), ACTN2(8), ACTN3(3), CSK(3), CTNNA1(12), CTNNA2(12), CTNNB1(12), PECAM1(2), PTK2(5), SRC(3), VCL(2)	6850060	67	44	67	24	34	18	7	2	6	0	0.0025	0.0082
185	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDK2(2), CDKN1B(3), CKS1B(1), CUL1(8), NEDD8(1), RB1(7), RBX1(1), SKP2(1), TFDP1(4)	2933124	31	24	31	7	7	4	10	1	8	1	0.0025	0.0083
186	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(4), JAK2(9), JAK3(8), PIAS1(4), PIAS3(4), PTPRU(12), REG1A(5), SOAT1(1)	4742888	47	31	45	13	23	11	4	0	7	2	0.0027	0.0089
187	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(2), F13A1(10), F2(3), FGA(13), FGB(2), FGG(4), PLAT(5), PLAU(3), PLG(9), SERPINB2(5), SERPINE1(3)	4518540	59	33	59	13	19	22	11	0	7	0	0.0029	0.0094
188	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(2), ACP2(2), ACP5(1), ACPP(4), ALPI(2), ALPL(1), ALPP(1), ALPPL2(1), CYP19A1(8), CYP1A1(7), CYP1A2(3), CYP2A13(7), CYP2A6(6), CYP2A7(5), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2F1(4), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(6), CYP4B1(9), CYP4F8(4), CYP51A1(3), PON1(6)	9878588	112	52	110	25	40	31	28	0	11	2	0.0029	0.0096
189	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(22), ABCA10(10), ABCA12(33), ABCA13(40), ABCA3(6), ABCA4(14), ABCA5(17), ABCA6(17), ABCA7(5), ABCA8(17), ABCA9(18), ABCB1(11), ABCB10(3), ABCB11(11), ABCB4(11), ABCB5(14), ABCB6(4), ABCB7(4), ABCB8(5), ABCB9(2), ABCC1(11), ABCC10(7), ABCC11(11), ABCC12(11), ABCC2(14), ABCC3(5), ABCC4(9), ABCC5(7), ABCC6(7), ABCC8(8), ABCC9(11), ABCD1(3), ABCD2(9), ABCD3(3), ABCD4(5), ABCG1(6), ABCG2(9), ABCG4(3), ABCG5(1), ABCG8(4), CFTR(12), TAP1(5), TAP2(5)	39840096	430	88	426	127	129	137	105	2	54	3	0.0031	0.010
190	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(5), CALCRL(6), CD97(5), CRHR1(2), CRHR2(5), ELTD1(7), EMR1(8), EMR2(6), GHRHR(2), GLP1R(7), GLP2R(5), GPR64(6), LPHN1(3), LPHN2(13), LPHN3(17), SCTR(3), VIPR1(4), VIPR2(3)	9335368	109	48	106	36	40	36	22	0	11	0	0.0035	0.011
191	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(3), AMD1(1), BHMT(5), CBS(3), CTH(2), DNMT1(19), DNMT3A(9), DNMT3B(8), MARS(6), MARS2(1), MAT1A(5), MAT2B(3), MTAP(1), MTFMT(2), MTR(7), TAT(5)	7033116	80	40	75	18	35	25	6	3	11	0	0.0041	0.013
192	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(2), CD3D(1), CD3G(2), IFNG(1), IL2(4), IL2RA(2), IL4(3), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7), TGFBR3(8), TOB1(2), TOB2(1)	3609216	52	25	51	15	19	17	7	0	9	0	0.0043	0.014
193	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(8), CD14(1), CD19(3), CD1A(3), CD1B(1), CD1C(1), CD1D(2), CD1E(6), CD2(3), CD22(10), CD33(2), CD34(1), CD36(1), CD37(2), CD38(2), CD3D(1), CD3G(2), CD4(2), CD44(3), CD5(4), CD55(4), CD7(1), CD8B(2), CD9(1), CR1(10), CR2(11), CSF1(2), CSF1R(3), CSF3R(10), DNTT(7), FCER2(1), FCGR1A(1), FLT3(5), FLT3LG(1), GP1BA(1), GP5(6), GYPA(1), HLA-DRA(5), HLA-DRB1(2), HLA-DRB5(1), IL11(1), IL11RA(1), IL1A(1), IL1B(1), IL1R1(4), IL1R2(7), IL2RA(2), IL3(3), IL4(3), IL4R(1), IL5RA(6), IL6(2), IL6R(3), IL7(2), IL7R(3), ITGA1(3), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGAM(8), ITGB3(9), KIT(8), KITLG(2), MME(10), MS4A1(4), TFRC(3), THPO(2), TPO(11)	27335152	266	79	260	87	100	103	37	4	20	2	0.0044	0.014
194	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(8), BAD(1), BAK1(1), BAX(1), BCL10(3), BCL2(1), BCL2L1(1), BCL2L11(3), BID(1), CASP8AP2(18), CASP9(2), CES1(5)	3871512	45	28	43	10	13	16	8	0	8	0	0.0044	0.014
195	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6)	1888992	24	19	24	9	3	9	11	0	1	0	0.0052	0.016
196	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(4), FMOD(2), KERA(7), LUM(6)	1221008	20	16	20	4	7	4	7	0	2	0	0.0057	0.018
197	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(2), B3GNT1(2), FUT1(4), FUT2(1), FUT9(5), GCNT2(11), ST8SIA1(3)	2048552	28	18	28	7	10	9	5	0	4	0	0.0057	0.018
198	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), AKR1C2(4), AKR1C3(2), AKR1C4(3), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), CYP1A1(7), CYP1A2(3), CYP1B1(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2F1(4), CYP2S1(3), CYP3A4(1), CYP3A43(2), CYP3A5(3), CYP3A7(6), DHDH(1), EPHX1(5), GSTA1(1), GSTA3(4), GSTA5(2), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(1), GSTO2(1), GSTZ1(2), MGST1(2), MGST3(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A1(8), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6)	18602456	190	63	189	45	47	65	52	1	24	1	0.0057	0.018
199	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(6), CHKA(4), PCYT1A(5), PDHA1(5), PDHA2(8), PEMT(1), SLC18A3(6)	2386116	37	26	36	17	12	12	10	0	3	0	0.0062	0.019
200	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(11), C5(13), C6(13), C7(5), ICAM1(2), IL1A(1), IL6(2), IL8(1), ITGA4(8), ITGAL(8), ITGB1(6), ITGB2(5), SELP(6), SELPLG(2), VCAM1(9)	8384284	92	42	90	29	32	30	18	0	11	1	0.0084	0.026
201	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QB(1), C1R(3), C1S(6), C2(4), C3(11), C5(13), C6(13), C7(5), C8A(6), C9(5)	5951592	67	31	67	20	21	23	12	0	10	1	0.0090	0.028
202	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD3G(2), CD4(2), FYN(5), HLA-DRA(5), HLA-DRB1(2), LCK(3), PTPRC(17), ZAP70(4)	3009476	41	22	41	9	10	16	6	0	7	2	0.0094	0.029
203	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(14), COL4A2(4), COL4A3(4), COL4A4(10), COL4A5(19), COL4A6(15), P4HB(2), SLC23A1(2), SLC23A2(7), SLC2A1(1), SLC2A3(1)	8705740	79	39	78	20	20	25	16	1	17	0	0.0099	0.030
204	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(1), BRAF(23), CHUK(6), CREB1(1), DAXX(1), FOS(1), GRB2(3), IKBKB(4), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K4(11), MAP2K5(4), MAP2K6(3), MAP3K1(8), MAP3K10(3), MAP3K11(4), MAP3K12(6), MAP3K13(9), MAP3K14(3), MAP3K2(3), MAP3K3(3), MAP3K4(18), MAP3K5(6), MAP3K6(6), MAP3K7(4), MAP3K8(2), MAP3K9(4), MAP4K1(3), MAP4K2(1), MAP4K3(4), MAP4K4(8), MAP4K5(2), MAPK1(2), MAPK10(8), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK4(1), MAPK6(3), MAPK7(3), MAPK8(7), MAPK9(5), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(1), MAX(1), MEF2A(4), MEF2C(9), MEF2D(1), MKNK1(1), MKNK2(3), NFKB1(6), PAK1(5), PAK2(3), RAF1(6), RELA(2), RIPK1(2), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA5(6), RPS6KB1(3), RPS6KB2(2), SHC1(3), SP1(2), STAT1(6), TGFB1(1), TGFB2(9), TGFBR1(9), TRADD(1), TRAF2(1)	32806560	311	80	286	76	96	85	85	4	41	0	0.010	0.030
205	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(8), CAP1(1), CCNB1(2), CDC25C(4), GNAI1(4), GNAS(6), GNB1(1), GNGT1(1), MAPK1(2), MAPK3(3), MYT1(13), PIN1(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RPS6KA1(1), SRC(3)	6838796	67	46	66	21	26	27	10	0	4	0	0.011	0.032
206	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), AGK(3), AGPAT1(2), AGPAT3(3), AGPAT4(8), AGPAT6(2), AKR1B1(3), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), CEL(1), DAK(4), DGAT2(4), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKI(10), DGKZ(3), GK(3), GK2(6), GLA(4), GLB1(3), GPAM(3), LCT(20), LIPA(1), LIPC(4), LIPF(3), LIPG(2), LPL(6), MGLL(1), PNLIP(7), PNLIPRP1(4), PNLIPRP2(2), PNPLA3(4), PPAP2B(1)	19663140	206	66	204	66	69	77	43	0	17	0	0.011	0.032
207	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(14), COL4A2(4), COL4A3(4), COL4A4(10), COL4A5(19), COL4A6(15), F10(1), F11(4), F12(2), F2(3), F5(21), F8(18), F9(6), FGA(13), FGB(2), FGG(4), KLKB1(6), PROC(1), PROS1(6), SERPINC1(3), SERPING1(5)	15139468	161	54	157	40	34	65	34	1	27	0	0.012	0.034
208	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(9), AGT(5), AGTR1(5), AGTR2(5), ANPEP(8), CPA3(3), CTSA(3), CTSG(3), ENPEP(9), LNPEP(8), MAS1(2), MME(10), NLN(3), REN(5)	7110260	80	42	80	17	22	29	19	0	10	0	0.012	0.035
209	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(2), IL6R(3), JAK1(4), JAK2(9), JAK3(8), PIAS3(4), PTPRU(12), REG1A(5), SRC(3), STAT3(2)	5233144	52	34	50	20	27	15	3	0	5	2	0.013	0.037
210	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(2), B3GNT1(2), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(1), B4GALT1(6), B4GALT2(3), B4GALT3(7), FUT1(4), FUT2(1), FUT3(4), FUT6(1), FUT9(5), GCNT2(11), ST3GAL6(7), ST8SIA1(3)	5195836	61	34	61	14	25	17	12	1	6	0	0.014	0.041
211	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(4), CYP2C9(7)	676032	11	9	11	2	3	3	4	0	1	0	0.015	0.043
212	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(8), GNAS(6), GNB1(1), GNGT1(1), PRKACA(1), PRKAR1A(5)	2167436	22	20	22	9	8	7	5	0	2	0	0.015	0.044
213	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(18), CPT1A(6), LEP(1), LEPR(9), PRKAA1(3), PRKAA2(9), PRKAB1(2), PRKAB2(1), PRKAG1(1), PRKAG2(3)	4891292	53	29	51	20	20	17	10	0	6	0	0.015	0.044
214	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(2), B3GNT7(6), B4GALT1(6), B4GALT2(3), B4GALT3(7), CHST1(7), CHST2(1), CHST4(7), FUT8(2), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2)	4036676	51	32	51	15	29	6	10	1	5	0	0.016	0.047
215	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(5), AGTR1(5), ATF2(1), EGFR(11), GNAQ(4), GRB2(3), MAP2K1(4), MAP2K2(1), MAP2K4(11), MAP3K1(8), MAPK1(2), MAPK3(3), MAPK8(7), MEF2A(4), MEF2C(9), MEF2D(1), PAK1(5), PRKCA(4), PTK2(5), PTK2B(1), RAF1(6), SHC1(3), SOS1(7), SRC(3), SYT1(1)	11472428	114	47	111	30	34	39	24	2	15	0	0.018	0.050
216	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ABP1(1), ACAT1(1), ACAT2(2), ACMSD(4), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), AOC2(4), AOC3(4), AOX1(8), CAT(3), CYP19A1(8), CYP1A1(7), CYP1A2(3), CYP2A13(7), CYP2A6(6), CYP2A7(5), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2F1(4), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(6), CYP4B1(9), CYP4F8(4), CYP51A1(3), DDC(1), ECHS1(2), EHHADH(2), GCDH(5), HAAO(2), HADHA(3), KMO(5), KYNU(7), MAOA(3), MAOB(1), SDS(2), TDO2(4), TPH1(3), WARS(2), WARS2(3)	18384232	197	68	196	56	68	69	42	1	16	1	0.019	0.053
217	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(11), GNAS(6), GNB1(1), GNGT1(1), GRB2(3), IGF1R(8), ITGB1(6), KLK2(3), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MKNK1(1), MKNK2(3), NGFR(3), PDGFRA(17), PPP2CA(1), PTPRR(5), RAF1(6), RPS6KA1(1), RPS6KA5(6), SHC1(3), SOS1(7), SRC(3), STAT3(2)	11210580	107	54	102	37	37	36	24	0	8	2	0.019	0.054
218	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(3), GNAQ(4), GNB1(1), GNGT1(1), HTR2C(8), PLCB1(8), TUB(5)	2402460	30	20	30	9	14	5	6	1	4	0	0.020	0.055
219	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA2(2), ANXA3(1), ANXA4(4), ANXA5(1), ANXA6(3), CYP11A1(4), EDN1(1), EDNRA(4), EDNRB(12), HSD11B1(1), PLA2G4A(8), PRL(3), PTGDR(1), PTGER2(1), PTGFR(7), PTGIR(1), PTGIS(5), PTGS1(6), PTGS2(3), TBXAS1(5)	6947220	74	37	72	19	30	23	14	0	7	0	0.022	0.061
220	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(6), CREBBP(25), DUSP1(2), EP300(15), IKBKB(4), IL1B(1), IL8(1), MAP2K3(6), MAP2K6(3), MAP3K14(3), MAP3K7(4), MAPK14(3), MYD88(2), NFKB1(6), NR3C1(4), RELA(2), TGFBR1(9), TGFBR2(7), TLR2(6)	10021124	109	43	108	34	35	30	28	3	13	0	0.022	0.062
221	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(5), GTF2F2(1), GTF2H1(4), GTF2H3(4), GTF2H4(1), GTF2IRD1(9), TAF1(12), TAF1L(22), TAF2(8), TAF4(5), TAF4B(6), TAF5(4), TAF5L(2), TAF6(3), TAF6L(2), TAF7(2), TAF7L(4), TAF9(1), TAF9B(1), TBPL1(1), TBPL2(1)	12111116	106	50	106	24	37	31	25	0	13	0	0.025	0.070
222	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(8), CREB1(1), FOS(1), GNAI1(4), GNAQ(4), GNAS(6), GNB1(1), GNGT1(1), MAP2K1(4), MAPK3(3), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), RAF1(6), RPS6KA3(5), SYT1(1)	11537852	95	54	94	31	45	21	16	0	13	0	0.025	0.070
223	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(2), CD4(2), CD80(1), HLA-DRA(5), HLA-DRB1(2), IL10(2), IL2(4), IL4(3)	1281264	21	13	21	8	8	11	0	0	0	2	0.026	0.072
224	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(6)	242816	6	5	6	0	4	1	0	0	1	0	0.026	0.073
225	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(8), GNAS(6), GNB1(1), GNGT1(1), PPP2CA(1), PRKAA1(3), PRKAA2(9), PRKAB1(2), PRKAB2(1), PRKACB(1), PRKACG(3), PRKAG1(1), PRKAG2(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3)	5079204	49	35	48	19	22	15	8	0	4	0	0.027	0.073
226	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(6), AKT3(1), ARHGEF11(11), BCL2(1), CDC42(1), DLG4(3), GNA13(2), LPA(10), MAP2K4(11), MAP3K1(8), MAP3K5(6), MAPK8(7), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PDK1(2), PHKA2(6), PI3(1), PIK3CB(2), PLD1(11), PLD2(2), PLD3(5), PTK2(5), RDX(3), ROCK1(15), ROCK2(6), SERPINA4(5), SRF(3)	16440040	148	54	147	45	59	44	23	3	19	0	0.028	0.075
227	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(5), ACACA(18), ACADL(2), ACADM(6), ACADSB(5), ACAT1(1), ACAT2(2), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(4), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(3), LDHA(2), LDHB(3), LDHC(2), MCEE(2), MLYCD(1), MUT(4), PCCA(9), PCCB(4), SDS(2), SUCLA2(5), SUCLG1(2)	11147916	119	45	117	24	42	38	20	1	18	0	0.028	0.075
228	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), ACO2(2), FH(1), IDH1(3), IDH2(7), MDH1(1), MDH2(1), SDHB(2), SUCLA2(5)	3003212	26	23	26	9	9	8	5	0	4	0	0.029	0.077
229	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(2), CD4(2), HLA-DRA(5), HLA-DRB1(2)	743664	11	9	11	4	4	5	0	0	0	2	0.030	0.081
230	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), GUSB(2), RPE(2), UGDH(4), UGP2(7), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A1(8), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6), XYLB(2)	8418552	82	33	81	17	18	33	17	0	14	0	0.030	0.081
231	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(7), GBA3(3), LPO(3), MPO(5), PRDX1(1), PRDX6(2), TPO(11), TYR(3)	3284228	35	27	34	16	19	7	4	0	5	0	0.031	0.082
232	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(8), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIK(1), BIRC2(4), BIRC3(7), CASP3(2), CASP6(2), CASP7(1), CASP8(11), CASP9(2), DFFA(3), DFFB(2), DIABLO(1)	4595200	49	30	48	9	12	18	10	0	9	0	0.031	0.082
233	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(2), BMP5(5), BMP6(3), BMP7(6), BMP8A(1), BTRC(5), CSNK1A1(2), CSNK1A1L(5), CSNK1D(4), CSNK1G1(1), CSNK1G3(3), DHH(1), FBXW11(8), GLI1(4), GLI2(4), GLI3(13), GSK3B(8), HHIP(5), IHH(1), LRP2(52), PRKACA(1), PRKACB(1), PRKACG(3), PRKX(2), PTCH1(9), PTCH2(6), RAB23(2), SMO(1), STK36(5), SUFU(4), WNT1(1), WNT10B(4), WNT11(3), WNT16(2), WNT2(1), WNT2B(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2), ZIC2(1)	20217240	203	73	201	84	90	57	30	1	25	0	0.032	0.085
234	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(2), ACAA2(1), ACAD8(1), ACAD9(5), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), AKR1C4(3), AKR1D1(1), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(3), CYP7A1(4), HADHB(2), HSD3B7(2), LIPA(1), RDH11(1), RDH12(3), RDH13(1), SLC27A5(4), SOAT1(1), SOAT2(1), SRD5A1(1), SRD5A2(2)	10829152	93	45	93	33	24	39	23	0	7	0	0.033	0.087
235	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(8), CFTR(12), GNAS(6), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), SLC9A3R1(3)	4287168	42	30	42	13	15	13	9	0	5	0	0.035	0.093
236	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(3), CASP10(2), CASP3(2), CASP6(2), CASP7(1), CASP8(11), CFLAR(3), DAXX(1), DFFA(3), DFFB(2), FAF1(4), LMNB1(4), LMNB2(1), MAP2K4(11), MAP3K1(8), MAP3K7(4), MAPK8(7), PAK1(5), PAK2(3), PRKDC(18), PTPN13(17), RB1(7), RIPK2(3), SPTAN1(13)	14479328	135	49	131	37	28	49	29	2	24	3	0.036	0.094
237	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(1), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), AOC2(4), AOC3(4), AOX1(8), DBH(5), DCT(13), DDC(1), FAH(2), GOT1(6), GOT2(1), GSTZ1(2), HGD(2), HPD(4), MAOA(3), MAOB(1), TAT(5), TPO(11), TYR(3)	10479052	112	52	110	47	39	39	25	1	8	0	0.037	0.095
238	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(1), CYP11A1(4), CYP11B1(9), CYP11B2(5), CYP17A1(2), CYP21A2(1), HSD11B1(1), HSD3B1(3), HSD3B2(1)	3002640	30	24	30	8	14	10	4	0	2	0	0.038	0.097
239	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(1), CYP11A1(4), CYP11B1(9), CYP11B2(5), CYP17A1(2), CYP21A2(1), HSD11B1(1), HSD3B1(3), HSD3B2(1)	3002640	30	24	30	8	14	10	4	0	2	0	0.038	0.097
240	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(3), AKR1D1(1), ARSB(5), ARSD(3), ARSE(2), CYP11B1(9), CYP11B2(5), HSD11B1(1), HSD17B2(2), HSD17B3(2), HSD17B8(1), HSD3B1(3), HSD3B2(1), SRD5A1(1), SRD5A2(2), STS(7), SULT1E1(2), SULT2A1(2), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2B15(2), UGT2B4(3)	8780836	76	40	75	13	33	23	9	0	11	0	0.038	0.099
241	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(1), CHUK(6), DAXX(1), EGF(3), EGFR(11), ETS1(1), ETS2(3), FOS(1), HOXA7(1), IKBKB(4), MAP2K1(4), MAP2K3(6), MAP2K4(11), MAP2K6(3), MAP3K1(8), MAP3K14(3), MAP3K5(6), MAPK1(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK8(7), NFKB1(6), PPP2CA(1), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCQ(5), RAF1(6), RELA(2), RIPK1(2), SP1(2), TNFRSF1A(1), TRAF2(1)	16568384	141	63	139	42	61	38	32	3	7	0	0.039	0.099
242	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(8), POLA2(2), POLB(3), POLD1(5), POLD2(1), POLD3(2), POLE(21), POLE2(1), POLE3(1), POLG(5), POLG2(1), POLH(5), POLI(10), POLK(3), POLL(1), POLM(2), POLQ(12), PRIM2(9), REV1(7), REV3L(22), RFC5(3)	14115892	124	45	118	35	30	47	26	0	19	2	0.039	0.099
243	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(9), AGT(5), AGTR2(5), EDN1(1), EDNRA(4), EDNRB(12), EGF(3), EGFR(11), FOS(1), NFKB1(6), PLCG1(4), PRKCA(4), RELA(2)	6918760	67	39	66	21	29	18	14	0	6	0	0.039	0.099
244	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(3), CAMK1G(5), FPR1(2), GNA15(3), GNB1(1), GNGT1(1), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAPK1(2), MAPK14(3), MAPK3(3), NCF1(1), NCF2(2), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB1(6), PAK1(5), PIK3C2G(9), PLCB1(8), PPP3CA(3), PPP3CB(5), PPP3CC(4), RAF1(6), RELA(2), SYT1(1)	13013564	114	49	113	38	43	29	19	4	19	0	0.040	0.10
245	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(8), ADORA2A(5), ADORA2B(1), ADORA3(3), LTB4R(1), P2RY1(6), P2RY2(3), P2RY6(1)	1894004	28	20	28	4	12	11	3	1	1	0	0.040	0.10
246	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(3), ALG6(3), CCKBR(5), CCR3(4), CCR5(1), CELSR1(8), CELSR2(9), CELSR3(5), CHRM2(11), CHRM3(4), EDNRA(4), EMR2(6), EMR3(8), FSHR(7), GHRHR(2), GNRHR(4), GPR116(11), GPR132(1), GPR133(8), GPR143(2), GPR17(1), GPR18(2), GPR55(1), GPR56(2), GPR61(4), GPR77(2), GPR84(6), GPR88(1), GRM1(12), GRPR(3), HRH4(2), LPHN2(13), LPHN3(17), NTSR1(1), OR2M4(8), OR8G2(1), P2RY13(2), PTGFR(7), SMO(1), SSTR2(3), TAAR5(6), TSHR(7), VN1R1(4)	22155400	212	76	207	83	83	63	42	5	19	0	0.040	0.10
247	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(4), CD4(2), HLA-DRA(5), HLA-DRB1(2), IL1B(1), IL4(3), IL5RA(6), IL6(2)	1735984	25	15	24	8	11	12	0	0	0	2	0.040	0.10
248	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(6), CCNE1(3), CDK2(2), CUL1(8), RB1(7), SKP2(1), TFDP1(4)	2955912	31	22	31	8	7	5	11	1	6	1	0.042	0.10
249	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(2), TGDS(1), UGDH(4), UGP2(7), UXS1(7)	1709536	22	16	22	5	7	8	4	0	3	0	0.043	0.11
250	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(8), BAD(1), BAX(1), BCL2(1), BCL2A1(3), BCL2L1(1), BOK(1), CASP1(2), CASP10(2), CASP2(4), CASP3(2), CASP4(3), CASP6(2), CASP7(1), CASP8(11), CASP9(2), CD40(1), CD40LG(6), CRADD(2), DAXX(1), DFFA(3), DFFB(2), FAS(2), FASLG(1), IKBKE(4), NFKB1(6), NGFR(3), NR3C1(4), NTRK1(6), PTPN13(17), RIPK1(2), SFRS2IP(3), TFG(6), TNFRSF1A(1), TRADD(1), TRAF1(2), TRAF2(1), TRAF3(6), TRAF6(4)	14918920	129	54	126	53	35	46	25	1	21	1	0.043	0.11
251	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(2), BIRC2(4), BIRC3(7), CASP3(2), CASP8(11), CFLAR(3), MAP2K4(11), MAP3K3(3), MAP3K7(4), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), NR2C2(4), RALBP1(6), RIPK1(2), TNFAIP3(3), TNFRSF1A(1), TRADD(1), TRAF2(1)	8990860	78	40	76	15	24	24	19	1	10	0	0.043	0.11
252	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(5), ADC(1), ALDH4A1(3), ALDH5A1(4), CAD(11), CPS1(14), EPRS(12), GAD1(9), GAD2(4), GCLC(4), GCLM(1), GFPT1(4), GFPT2(4), GLS2(2), GLUD1(2), GLUD2(6), GLUL(4), GMPS(5), GOT1(6), GOT2(1), GPT2(2), GSR(1), GSS(4), NADSYN1(2), NAGK(2), PPAT(6), QARS(8)	13279336	127	55	126	33	44	42	28	3	10	0	0.045	0.11
253	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(3), AASS(9), KARS(3)	1596912	16	13	16	4	4	4	5	0	3	0	0.046	0.11
254	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(2), ACAA2(1), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), AKR1C4(3), AKR1D1(1), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(3), CYP7A1(4), HADHB(2), SOAT2(1), SRD5A1(1), SRD5A2(2)	7894272	80	40	80	23	22	30	23	0	5	0	0.050	0.12
255	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), GNAI1(4), GNB1(1), GNGT1(1), ITGA1(3), ITGB1(6), MAP2K1(4), MAPK1(2), MAPK3(3), PLA2G4A(8), PLCB1(8), PRKCA(4), PTGS1(6), PTK2(5), RAF1(6), SRC(3), SYK(3), TBXAS1(5)	8223816	75	40	73	22	29	21	17	1	7	0	0.051	0.12
256	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(8), G6PD(3), GCLC(4), GCLM(1), GGT1(3), GPX1(1), GPX2(2), GPX3(3), GPX5(4), GSS(4), GSTA1(1), GSTA3(4), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(1), GSTO2(1), GSTZ1(2), IDH1(3), IDH2(7), MGST1(2), MGST3(1), PGD(1)	6072684	63	34	61	9	13	28	16	0	6	0	0.056	0.14
257	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(7), GBA3(3), LPO(3), MPO(5), PRDX6(2), TPO(11)	2867192	31	25	30	14	18	7	2	0	4	0	0.062	0.15
258	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT1(2), AGPAT3(3), AGPAT4(8), AGPAT6(2), CDS1(2), CDS2(4), CHAT(6), CHKA(4), CHPT1(1), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKI(10), DGKZ(3), ESCO1(11), ESCO2(4), ETNK1(2), ETNK2(2), GNPAT(2), GPAM(3), GPD1(1), GPD1L(3), GPD2(4), LCAT(1), MYST3(18), MYST4(10), PCYT1A(5), PCYT1B(5), PEMT(1), PISD(2), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLD1(11), PLD2(2), PNPLA3(4), PPAP2B(1), PTDSS1(7), SH3GLB1(4)	22300720	202	68	198	73	73	66	44	1	18	0	0.063	0.15
259	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(7), CD79A(3), CD79B(1), FOS(1), GRB2(3), LYN(4), MAP2K1(4), MAP3K1(8), MAPK14(3), MAPK3(3), MAPK8(7), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKCA(4), RAF1(6), SHC1(3), SOS1(7), SYK(3), SYT1(1), VAV1(13)	12787560	115	50	113	31	46	33	19	1	16	0	0.063	0.15
260	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(10), CR2(11), HLA-DRA(5), HLA-DRB1(2), ICAM1(2), ITGAL(8), ITGB2(5), PTPRC(17)	5071208	61	28	61	16	15	26	10	0	8	2	0.064	0.15
261	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(2), HLA-DRA(5), HLA-DRB1(2), IFNG(1), IFNGR1(3), IFNGR2(2), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL18R1(10), IL2(4), IL2RA(2), IL4(3), IL4R(1)	4232000	46	24	46	15	15	20	6	0	3	2	0.064	0.15
262	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(6), NR1I3(3), PTGS1(6), PTGS2(3)	1776376	21	17	21	6	9	7	4	0	1	0	0.065	0.15
263	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(1), ACAD9(5), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), DHRS1(1), DHRS2(3), DHRS3(2), ESCO1(11), ESCO2(4), MYST3(18), MYST4(10), PNPLA3(4), SH3GLB1(4)	8215268	88	40	87	31	28	27	26	1	6	0	0.065	0.15
264	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(1), IFNGR1(3), JAK1(4), JAK2(9), PTPRU(12), REG1A(5), STAT1(6)	3888348	40	24	38	11	20	8	7	0	3	2	0.065	0.15
265	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(24), ASH2L(2), C17orf79(1), CARM1(2), CTCFL(8), DOT1L(3), EED(2), EHMT1(2), EHMT2(3), EZH1(5), EZH2(4), FBXO11(5), HSF4(1), JMJD6(2), KDM6A(1), MEN1(2), MLL(21), MLL2(17), MLL3(16), MLL4(11), MLL5(17), NSD1(14), OGT(5), PAXIP1(6), PPP1CB(2), PPP1CC(2), PRDM2(15), PRDM7(2), PRDM9(19), PRMT1(1), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), RBBP5(2), SATB1(2), SETD1A(8), SETD2(16), SETD7(3), SETD8(2), SETDB1(8), SETDB2(3), SETMAR(1), SMYD3(4), STK38(2), SUV39H1(1), SUV39H2(3), SUV420H1(8), SUZ12(3), WHSC1(7), WHSC1L1(4)	40738944	302	77	299	85	112	81	59	2	45	3	0.067	0.15
266	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), AGPAT1(2), AGPAT3(3), AGPAT4(8), AKR1B1(3), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), CEL(1), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKZ(3), GK(3), GLA(4), GLB1(3), LCT(20), LIPC(4), LIPF(3), LIPG(2), LPL(6), PNLIP(7), PNLIPRP1(4), PNLIPRP2(2), PPAP2B(1)	16086632	174	55	172	50	58	60	40	0	16	0	0.067	0.16
267	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(5), CARS(6), DARS(4), EPRS(12), FARS2(5), GARS(3), HARS(2), IARS(6), KARS(3), LARS(5), LARS2(3), MARS(6), MARS2(1), NARS(3), QARS(8), RARS(4), SARS(2), TARS(6), WARS(2), WARS2(3), YARS(2)	10758584	91	43	91	16	30	26	23	2	10	0	0.069	0.16
268	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT1(6), B4GALT2(3), B4GALT3(7), B4GALT5(2), FUT8(2), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2)	2644184	30	22	30	6	15	5	7	0	3	0	0.069	0.16
269	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(5), AGTR2(5), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), F2(3), FYN(5), GNA11(1), GNAI1(4), GNB1(1), GNGT1(1), GRB2(3), JAK2(9), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK14(3), MAPK3(3), MAPK8(7), MAPT(5), MYLK(14), PLCG1(4), PRKCA(4), PTK2B(1), RAF1(6), SHC1(3), SOS1(7), STAT1(6), STAT3(2), SYT1(1)	14153160	118	50	116	37	32	43	29	1	11	2	0.070	0.16
270	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(9), AMY2A(5), AMY2B(1), ASCC3(19), ATP13A2(3), DDX18(3), DDX19A(3), DDX23(4), DDX4(3), DDX41(2), DDX47(3), DDX50(3), DDX52(2), DDX54(5), DDX55(3), DDX56(5), DHX58(3), ENPP1(4), ENPP3(4), ENTPD7(4), EP400(20), ERCC2(4), ERCC3(7), G6PC(4), G6PC2(1), GANC(3), GBA3(3), GBE1(5), GCK(2), GPI(2), GUSB(2), GYS1(2), GYS2(11), HK1(6), HK2(3), HK3(5), IFIH1(5), MGAM(13), MOV10L1(13), PGM1(4), PGM3(5), PYGB(4), PYGL(2), PYGM(4), RAD54B(8), RAD54L(3), RUVBL2(1), SETX(20), SI(15), SKIV2L2(3), SMARCA2(10), SMARCA5(7), TREH(2), UGDH(4), UGP2(7), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A1(8), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6), UXS1(7)	41445160	367	85	363	102	118	116	80	0	52	1	0.071	0.16
271	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(4), CREBBP(25), DFFA(3), DFFB(2), GZMA(3), GZMB(2), HMGB2(1)	3603940	41	25	41	11	12	13	9	0	7	0	0.072	0.16
272	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(1), ABP1(1), ACAT1(1), ACAT2(2), ACMSD(4), AFMID(1), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), AOC2(4), AOC3(4), AOX1(8), CARM1(2), CAT(3), CYP1A1(7), CYP1A2(3), CYP1B1(3), DDC(1), ECHS1(2), EHHADH(2), GCDH(5), HAAO(2), HADH(1), HADHA(3), HSD17B10(2), HSD17B4(3), INMT(2), KMO(5), KYNU(7), LCMT1(3), LCMT2(2), LNX1(11), MAOA(3), MAOB(1), METTL2B(2), METTL6(8), NFX1(8), OGDH(4), OGDHL(11), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), TDO2(4), TPH1(3), TPH2(8), WARS(2), WARS2(3), WBSCR22(1)	20235148	193	68	191	60	66	67	37	3	20	0	0.074	0.17
273	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(2), FH(1), IDH2(7), MDH1(1), OGDH(4), SDHA(6), SUCLA2(5)	3178052	26	23	26	10	11	6	5	0	4	0	0.075	0.17
274	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(5), ACACA(18), ACACB(15), ACADM(6), ACAT1(1), ACAT2(2), ACSS1(3), ACSS2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(4), ALDH7A1(3), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(3), HIBCH(1), LDHA(2), LDHAL6A(3), LDHAL6B(2), LDHB(3), LDHC(2), MCEE(2), MLYCD(1), MUT(4), PCCA(9), PCCB(4), SUCLA2(5), SUCLG1(2)	13361500	133	50	131	30	45	46	21	2	19	0	0.076	0.17
275	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF1(2), HLA-DRA(5), HLA-DRB1(2), IFNA1(1), IFNB1(1), IFNG(1), IL10(2), IL11(1), IL12A(1), IL12B(2), IL13(1), IL15(1), IL1A(1), IL2(4), IL3(3), IL4(3), IL6(2), IL7(2), IL8(1), PDGFA(1), TGFB1(1), TGFB2(9)	4404944	49	24	48	22	18	22	3	0	4	2	0.076	0.17
276	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(3), EPX(7), LPO(3), MPO(5), MTHFR(7), PRDX6(2), SHMT1(2), SHMT2(2), TPO(11)	3940752	43	30	42	16	24	11	5	0	3	0	0.078	0.17
277	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(3), NFYB(1), NFYC(3), RB1(7), SP1(2), SP3(3)	2252028	19	15	19	4	4	8	5	0	1	1	0.079	0.18
278	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(5), FARSA(1), FARSB(8), GOT1(6), GOT2(1), PAH(4), TAT(5), YARS(2), YARS2(4)	2933008	36	20	35	7	10	13	7	0	6	0	0.081	0.18
279	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(2), CASP2(4), CHUK(6), CRADD(2), IKBKB(4), MAP2K3(6), MAP2K4(11), MAP2K6(3), MAP3K1(8), MAP3K14(3), MAP4K2(1), MAPK14(3), MAPK8(7), NFKB1(6), RELA(2), RIPK1(2), TANK(6), TNFRSF1A(1), TRADD(1), TRAF2(1)	8222204	79	38	77	25	29	24	18	3	5	0	0.081	0.18
280	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(8), G6PD(3), GCLC(4), GCLM(1), GGT1(3), GPX1(1), GPX2(2), GPX3(3), GPX5(4), GPX6(3), GSR(1), GSS(4), GSTA1(1), GSTA3(4), GSTA5(2), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(1), GSTO2(1), GSTZ1(2), IDH1(3), IDH2(7), MGST1(2), MGST3(1), TXNDC12(2)	7308340	70	37	68	11	14	30	19	0	7	0	0.084	0.19
281	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(3), F3(2), F5(21), F7(3), FGA(13), FGB(2), FGG(4), PROC(1), PROS1(6), SERPINC1(3), TFPI(3)	5455876	62	29	62	17	14	30	12	0	6	0	0.086	0.19
282	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), GOT1(6), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME1(9), ME3(5), PGK1(3), PGK2(7), PKM2(2), RPE(2), RPIA(3), TKT(3), TKTL1(5), TKTL2(7), TPI1(1)	6643744	70	39	69	25	25	28	10	0	7	0	0.089	0.20
283	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1)	4511676	51	30	51	15	13	20	16	0	2	0	0.090	0.20
284	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(1), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), AOC2(4), AOC3(4), AOX1(8), CARM1(2), DBH(5), DCT(13), DDC(1), ECH1(1), ESCO1(11), ESCO2(4), FAH(2), GOT1(6), GOT2(1), GSTZ1(2), HGD(2), HPD(4), LCMT1(3), LCMT2(2), MAOA(3), MAOB(1), METTL2B(2), METTL6(8), MYST3(18), MYST4(10), PNPLA3(4), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), SH3GLB1(4), TAT(5), TPO(11), TYR(3), TYRP1(2), WBSCR22(1)	19823904	199	67	195	74	69	66	45	4	15	0	0.091	0.20
285	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(4), ALDH1A2(6), BCMO1(4), RDH5(1)	1303708	15	13	15	2	6	4	4	0	1	0	0.092	0.20
286	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(3), AP2M1(4), BAD(1), BTK(7), EEA1(9), GRASP(1), GSK3A(2), GSK3B(8), LYN(4), PDPK1(1), PFKL(1), PFKM(4), PFKP(2), PLCG1(4), PRKCE(6), RPS6KB1(3), VAV2(4)	8601776	66	36	66	19	23	20	12	0	10	1	0.094	0.20
287	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(4), FOS(1), GRB2(3), IL6(2), IL6R(3), IL6ST(3), JAK1(4), JAK2(9), JAK3(8), MAP2K1(4), MAPK3(3), PTPN11(5), RAF1(6), SHC1(3), SOS1(7), SRF(3), STAT3(2)	8097604	70	37	67	16	22	26	12	0	8	2	0.095	0.20
288	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(4), MDH1(1), ME1(9), PC(6), PDHA1(5), SLC25A11(1)	3120356	26	23	26	8	12	7	3	0	4	0	0.10	0.21
289	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(4), CDC40(4), CLK3(3), CLK4(2), COL2A1(9), CPSF1(5), CPSF2(1), CPSF3(2), CPSF4(4), CSTF1(2), CSTF2T(7), CSTF3(4), DDX1(4), DDX20(4), DHX15(3), DHX16(6), DHX38(11), DHX8(6), DHX9(5), DICER1(8), DNAJC8(2), LSM2(1), METTL3(4), NCBP1(6), NCBP2(1), NONO(2), NUDT21(1), NXF1(7), PABPN1(1), PAPOLA(3), PHF5A(1), POLR2A(6), PPM1G(1), PRPF18(4), PRPF3(1), PRPF4(4), PRPF4B(9), PRPF8(11), PSKH1(1), PTBP1(1), PTBP2(4), RBM17(2), RBM5(3), RNGTT(6), RNMT(4), RNPS1(1), SF3A1(3), SF3A2(1), SF3A3(1), SF3B1(10), SF3B2(2), SF3B4(4), SFRS14(2), SFRS4(2), SNRPA(1), SNRPB(1), SNRPB2(1), SNRPD3(1), SNRPE(2), SNRPN(2), SNURF(1), SPOP(2), SRPK1(9), SRPK2(4), SRRM1(11), SUPT5H(11), TXNL4A(1), U2AF1(2), U2AF2(3), XRN2(8)	35458112	266	77	266	73	85	76	62	3	40	0	0.10	0.21
290	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(2), HGD(2)	576560	6	5	6	4	1	2	2	0	1	0	0.10	0.22
291	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(5), AARS2(6), CARS(6), CARS2(1), DARS(4), DARS2(3), EPRS(12), FARS2(5), FARSA(1), FARSB(8), GARS(3), HARS(2), HARS2(4), IARS(6), IARS2(6), KARS(3), LARS(5), LARS2(3), MARS(6), MARS2(1), MTFMT(2), NARS(3), NARS2(6), QARS(8), RARS(4), RARS2(5), SARS(2), SARS2(2), TARS(6), TARS2(5), VARS(1), VARS2(6), WARS(2), WARS2(3), YARS(2), YARS2(4)	17925080	151	55	150	29	52	44	34	2	19	0	0.11	0.22
292	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(8), ARHGDIB(3), BIRC2(4), BIRC3(7), CASP1(2), CASP10(2), CASP2(4), CASP3(2), CASP4(3), CASP6(2), CASP7(1), CASP8(11), CASP9(2), DFFA(3), DFFB(2), GZMB(2), LMNB1(4), LMNB2(1)	6502824	63	32	61	15	13	25	13	0	12	0	0.11	0.23
293	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(2), CHAT(6), DBH(5), DDC(1), GAD1(9), GAD2(4), HDC(8), MAOA(3), PAH(4), SLC18A3(6), TPH1(3)	4854580	51	35	51	24	19	20	9	0	3	0	0.11	0.23
294	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(2), BDKRB2(3), CAV1(1), CHRM1(3), CHRNA1(4), FLT1(12), FLT4(5), KDR(10), NOS3(2), PDE3A(5), PDE3B(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKG1(9), PRKG2(5), RYR2(59), SLC7A1(2), SYT1(1), TNNI1(2)	13801952	145	54	145	56	46	54	31	1	13	0	0.11	0.24
295	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(6), CCNB1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(2), CDC25A(2), CDK2(2), CDK4(3), CDK6(1), CDK7(1), CDKN1A(1), CDKN1B(3), CDKN2A(1), CDKN2C(1), RB1(7), RBL1(5), TFDP1(4)	5369992	46	31	46	12	14	10	13	1	7	1	0.11	0.24
296	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(4), AASDHPPT(3), AASS(9), KARS(3)	2347060	20	15	20	8	5	6	6	0	3	0	0.11	0.24
297	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(3), B3GALNT1(4), B3GALT5(4), FUT1(4), FUT2(1), FUT9(5), GLA(4), HEXB(3), NAGA(1), ST3GAL1(1), ST3GAL2(1), ST8SIA1(3)	3554180	34	20	33	12	14	8	7	0	5	0	0.12	0.24
298	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(3), IFNB1(1), JAK1(4), PTPRU(12), REG1A(5), STAT1(6), STAT2(7), TYK2(1)	4233004	39	27	37	9	22	7	6	0	4	0	0.12	0.24
299	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(1), CAPN1(2), CAPN10(3), CAPN11(2), CAPN2(6), CAPN3(6), CAPN5(5), CAPN6(3), CAPN7(4), CAPN9(1), CAPNS1(1), CAV1(1), CAV2(1), CAV3(3), CDC42(1), CSK(3), DOCK1(7), FYN(5), GIT2(7), GRB2(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGAD(8), ITGAE(7), ITGAL(8), ITGAM(8), ITGAV(5), ITGAX(6), ITGB1(6), ITGB2(5), ITGB3(9), ITGB4(3), ITGB5(6), ITGB6(6), ITGB7(4), ITGB8(5), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K6(3), MAPK10(8), MAPK12(2), MAPK4(1), MAPK6(3), MAPK7(3), MYLK2(3), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PDPK1(1), PIK3R2(1), PTK2(5), RAP1B(2), RAPGEF1(6), RHO(3), ROCK1(15), ROCK2(6), SEPP1(1), SHC1(3), SHC3(1), SORBS1(11), SOS1(7), SRC(3), TLN1(7), TNS1(14), VASP(3), VAV2(4), VAV3(12), VCL(2), ZYX(1)	45937212	373	98	365	137	126	128	66	9	44	0	0.12	0.24
300	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(3), ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADK(1), ADSL(7), ADSS(2), AK2(1), AK5(5), ALLC(5), AMPD1(9), AMPD2(5), AMPD3(3), ATIC(4), ATP1B1(1), ATP5A1(5), ATP5B(4), ATP5C1(4), ATP5D(1), ATP5F1(1), ATP5G3(1), ATP5J2(1), DCK(2), ENPP1(4), ENPP3(4), ENTPD1(2), FHIT(1), GART(3), GMPS(5), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(8), GUCY2D(8), GUCY2F(11), HPRT1(2), IMPDH1(2), IMPDH2(4), ITPA(2), NPR1(6), NPR2(10), NT5E(3), NT5M(1), PAICS(1), PAPSS1(2), PAPSS2(4), PDE1A(4), PDE4A(4), PDE4B(5), PDE4C(2), PDE4D(4), PDE5A(6), PDE6B(5), PDE6C(10), PDE7B(4), PDE8A(1), PDE9A(6), PFAS(1), PKM2(2), POLB(3), POLD1(5), POLD2(1), POLE(21), POLG(5), POLL(1), POLQ(12), POLR1B(8), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLRMT(1), PPAT(6), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RRM1(2), RRM2(2)	43688348	393	98	386	118	132	136	69	3	53	0	0.12	0.24
301	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT3(3), AGPAT4(8), AGPAT6(2), AGPS(3), CHPT1(1), ENPP2(14), ENPP6(2), PAFAH1B1(3), PAFAH1B3(2), PAFAH2(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLD1(11), PLD2(2), PPAP2B(1)	7859452	69	36	66	29	28	24	12	0	5	0	0.12	0.24
302	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(5), CCR3(4), CCR4(1), CCR5(1), CCR7(3), CD28(2), CD4(2), CXCR4(4), IFNG(1), IFNGR1(3), IFNGR2(2), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL18R1(10), IL2(4), IL4(3), IL4R(1), TGFB1(1), TGFB2(9)	6575564	67	33	68	31	17	34	9	0	7	0	0.12	0.24
303	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(3), ALG10B(7), ALG11(1), ALG12(2), ALG13(1), ALG14(1), ALG2(3), ALG3(1), ALG5(3), ALG6(3), ALG8(6), ALG9(2), B4GALT1(6), B4GALT2(3), B4GALT3(7), DAD1(2), DDOST(2), DHDDS(1), DPAGT1(2), DPM1(1), FUT8(2), GANAB(4), MAN1A1(5), MAN1A2(2), MAN1B1(2), MAN1C1(7), MAN2A1(12), MGAT1(2), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(2), RPN2(1), ST6GAL1(1), STT3B(6)	14281672	112	52	110	28	37	36	30	0	9	0	0.12	0.24
304	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(4), BAIAP2(1), CASP1(2), CASP3(2), CASP7(1), CASP8(11), INSR(6), ITCH(3), MAGI1(13), MAGI2(11), RERE(3), WWP1(8), WWP2(4)	7926888	69	38	67	22	21	22	13	0	13	0	0.12	0.25
305	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(6), CCNA2(3), CCNE1(3), CCNE2(2), CDK2(2), CDK4(3), CDKN1B(3), CDKN2A(1), E2F2(1), E2F4(1), PRB1(1)	2935608	26	20	26	7	7	6	7	1	5	0	0.12	0.25
306	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(4), ALDOA(1), ALDOB(5), ALDOC(3), TPI1(1)	1279096	14	13	14	1	4	7	3	0	0	0	0.12	0.25
307	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(5), ABP1(1), ACADL(2), ACADM(6), ACADSB(5), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), AOC2(4), AOC3(4), CNDP1(3), DPYD(14), DPYS(7), ECHS1(2), EHHADH(2), GAD1(9), GAD2(4), HADHA(3), MLYCD(1), SDS(2), SMS(2), UPB1(5)	9766456	114	45	113	28	40	41	19	1	13	0	0.13	0.25
308	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(7), ADCY4(9), ADCY6(1), ADCY8(12), CACNA1A(17), CACNA1B(11), GNAS(6), GNAT3(2), GNB1(1), GNB3(3), GNG3(2), GRM4(7), ITPR3(12), KCNB1(5), PDE1A(4), PLCB2(3), PRKACA(1), PRKACB(1), PRKACG(3), PRKX(2), SCNN1A(3), SCNN1B(4), SCNN1G(5), TAS1R1(7), TAS1R2(7), TAS2R1(2), TAS2R10(6), TAS2R13(3), TAS2R14(1), TAS2R16(3), TAS2R3(1), TAS2R38(3), TAS2R39(3), TAS2R4(2), TAS2R41(1), TAS2R46(2), TAS2R5(2), TAS2R50(5), TAS2R60(2), TAS2R7(1), TAS2R8(2), TAS2R9(3)	19170972	177	68	174	67	75	61	29	0	12	0	0.13	0.25
309	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(2), ACAA2(1), ACADL(2), ACADM(6), ACADSB(5), ACAT1(1), ACAT2(2), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(4), ALDH9A1(1), AOX1(8), BCAT1(1), BCKDHA(3), BCKDHB(1), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2), HMGCL(1), MCCC1(8), MCCC2(2), MCEE(2), MUT(4), OXCT1(3), PCCA(9), PCCB(4), SDS(2)	12168408	113	48	112	27	41	41	15	0	16	0	0.13	0.25
310	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(7), PARK2(6), SNCA(1), SNCAIP(3), UBE2E2(1), UBE2F(1), UBE2G1(2), UBE2L3(2)	2137016	23	17	23	8	6	11	5	0	1	0	0.13	0.25
311	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(6), MAP3K14(3), MAPK14(3), MAPK8(7), NFKB1(6), RELA(2), TNFRSF13B(4), TNFRSF17(2), TNFSF13(2), TNFSF13B(1), TRAF2(1), TRAF3(6), TRAF5(6), TRAF6(4)	4968172	53	29	52	15	21	12	9	3	8	0	0.13	0.25
312	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(3), BAG4(2), CASP2(4), CASP3(2), CASP8(11), CRADD(2), DFFA(3), DFFB(2), LMNB1(4), LMNB2(1), MADD(14), MAP2K4(11), MAP3K1(8), MAP3K7(4), MAPK8(7), PAK1(5), PAK2(3), PRKDC(18), RB1(7), RIPK1(2), SPTAN1(13), TNFRSF1A(1), TRADD(1), TRAF2(1)	13471804	129	48	126	41	36	35	32	2	22	2	0.13	0.25
313	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(4), ACTN1(5), ACTN2(8), ACTN3(3), BCR(7), CAPN1(2), CAPNS1(1), CAPNS2(1), CAV1(1), CRKL(2), CSK(3), FYN(5), GRB2(3), ITGA1(3), ITGB1(6), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MAPK8(7), PPP1R12B(9), PTK2(5), RAF1(6), RAP1A(2), ROCK1(15), SHC1(3), SOS1(7), SRC(3), TLN1(7), VCL(2), ZYX(1)	15965992	131	60	128	36	51	43	25	1	11	0	0.13	0.25
314	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(5), EGF(3), EGFR(11), GRB2(3), MAP2K1(4), MAPK1(2), MAPK3(3), PTPRB(4), RAF1(6), RASA1(9), SHC1(3), SOS1(7), SPRY1(3), SPRY4(2), SRC(3)	8266640	68	35	66	25	24	21	17	0	6	0	0.13	0.25
315	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(3), GRIN1(1), GRIN2A(21), GRIN2B(10), GRIN2C(4), GRIN2D(5), NOS1(11), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), SYT1(1)	8572868	85	40	85	41	41	22	12	0	9	1	0.13	0.26
316	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(4), ACO1(4), ACO2(2), ACSS1(3), ACSS2(6), FH(1), IDH1(3), IDH2(7), MDH1(1), MDH2(1), SUCLA2(5)	4470360	37	26	37	12	15	11	6	1	4	0	0.14	0.27
317	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(9), AMY2A(5), AMY2B(1), ENPP1(4), ENPP3(4), G6PC(4), GANAB(4), GBA3(3), GBE1(5), GCK(2), GPI(2), GUSB(2), GYS1(2), GYS2(11), HK1(6), HK2(3), HK3(5), MGAM(13), PGM1(4), PGM3(5), PYGB(4), PYGL(2), PYGM(4), SI(15), UCHL1(2), UCHL3(2), UGDH(4), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2B15(2), UGT2B4(3), UXS1(7)	18953476	158	57	158	54	52	52	32	0	22	0	0.14	0.27
318	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(3), EPX(7), LPO(3), MPO(5), PRDX1(1), PRDX6(2), SHMT1(2), SHMT2(2), TPO(11)	4010432	37	28	36	16	22	8	3	0	4	0	0.14	0.27
319	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(5), FOS(1), MAP2K1(4), MAPK1(2), MAPK3(3), NFKB1(6), PLCB1(8), PRKCA(4), RAF1(6), RELA(2)	5163740	41	24	40	14	18	9	8	1	5	0	0.14	0.28
320	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(8), BIRC2(4), BIRC3(7), CASP10(2), CASP3(2), CASP7(1), CASP8(11), CASP9(2), DFFA(3), DFFB(2), GZMB(2), SCAP(2), SREBF1(1), SREBF2(2)	6115608	49	29	48	16	9	19	10	0	11	0	0.14	0.28
321	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS1(6), ALAS2(6), BLVRA(2), BLVRB(2), COX10(2), COX15(3), CP(6), CPOX(1), EPRS(12), FECH(3), FTMT(4), GUSB(2), HCCS(3), HMBS(2), HMOX1(2), HMOX2(3), MMAB(2), PPOX(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A1(8), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6), UROD(1), UROS(1)	13510988	129	46	126	28	34	59	23	0	13	0	0.15	0.28
322	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3D(1), CD3G(2), ETV5(6), IFNG(1), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL18R1(10), JAK2(9), MAP2K6(3), MAPK14(3), MAPK8(7), STAT4(3), TYK2(1)	6224996	58	28	59	23	10	25	12	1	8	2	0.15	0.29
323	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(6), CTH(2), GOT1(6), GOT2(1), LDHA(2), LDHB(3), LDHC(2)	2260944	22	15	21	4	9	7	3	0	3	0	0.15	0.29
324	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(6), CD3D(1), CD3G(2), GZMB(2), HLA-A(3), ICAM1(2), ITGAL(8), ITGB2(5)	2853352	29	19	28	8	7	7	6	0	8	1	0.15	0.29
325	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5R1(1), EGR1(3), KLK2(3), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), NGFR(3), RAF1(6)	2765088	26	19	23	7	9	7	6	0	4	0	0.16	0.30
326	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(2), CDC25B(5), CDC25C(4), CSK(3), GRB2(3), PRKCA(4), PTPRA(2), SRC(3)	3135504	28	23	28	9	7	14	6	1	0	0	0.16	0.30
327	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRA(2), BLVRB(2), CP(6), CPOX(1), EPRS(12), FECH(3), GUSB(2), HCCS(3), HMBS(2), HMOX1(2), HMOX2(3), PPOX(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2B15(2), UGT2B4(3), UROD(1), UROS(1)	8767900	68	36	67	19	22	27	12	0	7	0	0.16	0.30
328	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(5), GAD1(9), HDC(8), TPH1(3)	1993740	25	19	25	8	9	12	3	0	1	0	0.16	0.30
329	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CDO1(1), CSAD(2), GAD1(9), GAD2(4), GGT1(3)	1951412	21	17	19	7	8	11	2	0	0	0	0.16	0.31
330	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(1), CREBBP(25), EP300(15), NCOA3(11), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RXRA(1)	6877044	68	35	68	16	21	22	15	2	8	0	0.17	0.31
331	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(7), DLG4(3), EPHB2(8), F2(3), F2RL1(1), F2RL2(3), MAP2K5(4), MAPK1(2), MAPK7(3), MAPK8(7), MYEF2(7), PLD1(11), PLD2(2), PLD3(5), PTK2(5), RAF1(6), RASAL1(2), SRC(3), TEC(3), VAV1(13)	9394616	98	43	96	30	46	30	15	1	6	0	0.17	0.31
332	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(3), FUT1(4), FUT2(1), FUT9(5), GLA(4), HEXB(3), NAGA(1), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), ST8SIA1(3)	3348292	28	19	28	11	9	7	7	0	5	0	0.17	0.31
333	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA3(3), PSMA4(2), PSMA5(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(2), PSMB6(2), PSMB8(3), PSMB9(4)	2851344	23	18	23	6	6	7	5	2	3	0	0.17	0.32
334	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(6), CARS2(1), CDO1(1), CTH(2), GOT1(6), GOT2(1), LDHA(2), LDHAL6A(3), LDHAL6B(2), LDHB(3), LDHC(2), SDS(2), SULT1B1(4), SULT1C2(2), SULT1C4(3), SULT4A1(1)	4214500	41	22	38	7	16	14	6	1	4	0	0.17	0.32
335	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5R1(1), CSNK1D(4), DRD1(1), DRD2(5), GRM1(12), PLCB1(8), PPP1R1B(1), PPP2CA(1), PPP3CA(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3)	5320056	49	32	49	19	22	10	8	2	7	0	0.17	0.32
336	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(7), FOS(1), GRB2(3), IL3(3), JAK2(9), MAP2K1(4), MAPK3(3), PTPN6(4), RAF1(6), SHC1(3), SOS1(7), STAT5B(3)	5724296	53	28	50	11	20	16	9	0	6	2	0.18	0.32
337	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F11(4), F12(2), F13B(5), F2(3), F5(21), F7(3), F8(18), F9(6), FGA(13), FGB(2), FGG(4), LPA(10), PLAT(5), PLAU(3), PLG(9), SERPINB2(5), SERPINE1(3), VWF(15)	11757428	132	45	129	44	33	59	23	0	17	0	0.18	0.32
338	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(11), CAPN2(6), CAPNS1(1), CAPNS2(1), EP300(15), HDAC1(2), HDAC2(2), MEF2D(1), NFATC1(2), NFATC2(5), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKCA(4), SYT1(1)	8018748	63	35	63	17	27	13	11	1	11	0	0.18	0.32
339	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(2), HADH(1), HADHA(3), HADHB(2), HSD17B10(2), HSD17B4(3), MECR(1), PPT2(2)	2848532	17	14	17	9	3	5	2	0	7	0	0.18	0.32
340	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(9), AP2A1(3), AP2M1(4), BIN1(2), DNM1(11), EPN1(2), EPS15(7), PICALM(2), PPP3CA(3), PPP3CB(5), PPP3CC(4), SYNJ1(11), SYNJ2(6), SYT1(1)	7621532	70	30	67	25	22	22	10	0	16	0	0.18	0.33
341	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(5), ABAT(5), ADSL(7), ADSS(2), AGXT2(5), ASL(2), ASNS(1), ASPA(5), CAD(11), CRAT(3), DARS(4), DDO(2), GAD1(9), GAD2(4), GOT1(6), GOT2(1), GPT2(2), NARS(3), PC(6)	8800792	83	44	82	29	38	30	10	0	5	0	0.18	0.33
342	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(6), LARS(5), LARS2(3), PDHA1(5), PDHA2(8), PDHB(2)	3376212	30	19	29	7	11	9	6	0	4	0	0.18	0.33
343	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(6), SPCS1(1), SPCS3(1)	1054048	10	9	8	3	6	1	1	0	2	0	0.18	0.33
344	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(7), CYP2A6(6), CYP2A7(5), XDH(7)	2686328	28	18	28	12	7	11	6	0	4	0	0.18	0.33
345	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(4), ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(2), ARPC2(2), NCK1(1), NCKAP1(9), NTRK1(6), PIR(1), PSMA7(1), WASF1(3), WASF2(2), WASF3(4), WASL(7)	5208456	52	29	52	11	17	17	12	0	6	0	0.19	0.35
346	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(4), LIPT1(4)	512736	8	6	8	1	0	6	1	0	1	0	0.20	0.35
347	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(5), DYRK1B(4), GLI2(4), GLI3(13), GSK3B(8), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), SMO(1), SUFU(4)	5424900	52	31	52	24	22	14	8	0	8	0	0.20	0.35
348	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(3), ENO3(4), FARS2(5), GOT1(6), GOT2(1), PAH(4), TAT(5), YARS(2)	2781724	30	19	29	7	8	11	6	0	5	0	0.20	0.35
349	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), GOT1(6), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME1(9), ME2(3), ME3(5), PGK1(3), PKM2(2), RPE(2), RPIA(3), TKT(3), TPI1(1)	5935540	54	33	53	18	19	21	8	0	6	0	0.20	0.36
350	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(2), TGDS(1), UGDH(4), UXS1(7)	1358528	15	12	15	4	5	6	2	0	2	0	0.20	0.36
351	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CDKN1A(1), GNAQ(4), MARCKS(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKCA(4), SP1(2), SP3(3), SYT1(1)	6903604	49	33	49	17	22	11	5	0	11	0	0.21	0.36
352	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(25), EP300(15), LPL(6), NCOA1(8), NCOA2(7), PPARG(1), RXRA(1)	6220160	63	30	63	20	19	19	17	1	7	0	0.21	0.36
353	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(5), ABP1(1), ACADM(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), AOC2(4), AOC3(4), CNDP1(3), DPYD(14), DPYS(7), ECHS1(2), EHHADH(2), GAD1(9), GAD2(4), HADHA(3), HIBCH(1), MLYCD(1), SMS(2), UPB1(5)	9081504	99	41	98	28	33	37	16	1	12	0	0.21	0.37
354	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(4), ACO1(4), ACO2(2), CLYBL(6), DLD(1), DLST(1), FH(1), IDH1(3), IDH2(7), IDH3A(4), IDH3G(2), MDH1(1), MDH2(1), OGDH(4), OGDHL(11), PC(6), PCK1(3), PCK2(3), SDHA(6), SDHB(2), SDHD(1), SUCLA2(5), SUCLG1(2)	10087580	80	46	79	30	31	24	16	1	8	0	0.21	0.37
355	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), CHPT1(1), LCMT1(3), LCMT2(2), METTL2B(2), METTL6(8), PCYT1A(5), PCYT1B(5), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), WBSCR22(1)	4760052	43	28	42	16	12	14	11	2	4	0	0.21	0.37
356	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(6), AKT3(1), ASAH1(3), BRAF(23), DAG1(5), DRD2(5), EGFR(11), EPHB2(8), GRB2(3), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), KCNJ3(6), KCNJ5(4), KCNJ9(3), MAPK1(2), PI3(1), PIK3CB(2), PITX2(2), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), RAF1(6), RGS20(4), SHC1(3), SOS1(7), SOS2(11), SRC(3), STAT3(2), TERF2IP(2)	19968248	203	64	181	54	76	56	54	1	15	1	0.22	0.38
357	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(3), CBS(3), CTH(2), MUT(4)	1640048	13	11	13	1	5	4	0	0	4	0	0.23	0.39
358	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(7), BLNK(1), FOS(1), GRB2(3), LYN(4), MAP2K1(4), MAP3K1(8), MAPK1(2), MAPK3(3), MAPK8IP3(2), PAPPA(18), RPS6KA1(1), RPS6KA3(5), SHC1(3), SOS1(7), SYK(3), VAV1(13), VAV2(4), VAV3(12)	10704780	102	47	100	23	38	39	16	0	9	0	0.23	0.40
359	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(3), ABO(2), B3GALNT1(4), B3GALT1(1), B3GALT2(3), B3GALT4(1), B3GALT5(4), B3GNT1(2), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(1), B4GALNT1(4), B4GALT1(6), B4GALT2(3), B4GALT3(7), B4GALT6(5), FUT1(4), FUT2(1), FUT3(4), FUT6(1), FUT9(5), GCNT2(11), PIGA(1), PIGB(2), PIGG(3), PIGK(4), PIGM(3), PIGN(2), PIGO(3), PIGQ(1), PIGS(2), PIGT(3), PIGU(1), PIGV(2), PIGX(4), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2), ST3GAL6(7), ST6GALNAC3(4), ST6GALNAC4(2), ST6GALNAC5(6), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(6), UGCG(2)	16392716	148	50	147	44	57	42	29	1	19	0	0.23	0.40
360	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), GRB2(3), HBXIP(2), PTK2B(1), SHC1(3), SOS1(7), SRC(3)	2968856	20	17	19	7	2	10	5	0	3	0	0.23	0.40
361	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(1), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH7A1(3), ALDH9A1(1), AMDHD1(4), AOC2(4), AOC3(4), ASPA(5), CARM1(2), CNDP1(3), DDC(1), FTCD(2), HAL(4), HARS(2), HARS2(4), HDC(8), HNMT(4), LCMT1(3), LCMT2(2), MAOA(3), MAOB(1), METTL2B(2), METTL6(8), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), PRPS1(1), PRPS2(2), UROC1(3), WBSCR22(1)	13338664	118	52	116	43	43	41	23	2	9	0	0.24	0.40
362	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(1), IARS(6), IARS2(6), ILVBL(2), LARS(5), LARS2(3), PDHA1(5), PDHA2(8), PDHB(2), VARS(1), VARS2(6)	5917736	46	29	45	14	20	12	8	0	6	0	0.24	0.40
363	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), ACO2(2), DLD(1), DLST(1), FH(1), IDH1(3), IDH2(7), IDH3A(4), IDH3G(2), MDH1(1), MDH2(1), PC(6), PCK1(3), SDHA(6), SDHB(2), SUCLA2(5), SUCLG1(2)	6978460	51	34	51	22	20	17	7	0	7	0	0.24	0.40
364	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(6), CREBBP(25), EP300(15), HDAC3(2), IKBKB(4), NFKB1(6), RELA(2), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF6(4)	7527600	68	34	68	21	26	18	16	1	7	0	0.24	0.41
365	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(11), ABCB11(11), ABCB4(11), ABCC1(11), ABCC3(5)	4897596	49	26	49	13	9	18	14	1	7	0	0.24	0.41
366	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(6), EPHB1(9), FYN(5), ITGA1(3), ITGB1(6), L1CAM(4), LYN(4), RAP1B(2), SELP(6)	5303624	49	28	48	14	19	18	8	0	4	0	0.24	0.41
367	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(18), ATP4A(10), ATP4B(1), ATP5A1(5), ATP5B(4), ATP5C1(4), ATP5D(1), ATP5F1(1), ATP5G3(1), ATP5J2(1), ATP5L(2), ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(9), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), COX10(2), COX15(3), COX17(1), COX4I1(2), COX4I2(3), COX6A2(1), COX6C(1), COX7A1(1), COX7B2(1), COX8C(1), CYC1(1), LHPP(2), NDUFA1(1), NDUFA10(2), NDUFA12(2), NDUFA13(1), NDUFA4(2), NDUFA9(3), NDUFB1(1), NDUFB2(1), NDUFB3(1), NDUFB6(1), NDUFB9(2), NDUFC2(1), NDUFS1(6), NDUFS2(3), NDUFS3(2), NDUFS4(1), NDUFS5(2), NDUFS6(2), NDUFV1(2), NDUFV3(1), PPA1(2), PPA2(3), SDHA(6), SDHB(2), SDHD(1), TCIRG1(2), UQCRB(2), UQCRC1(2), UQCRC2(3), UQCRFS1(1), UQCRH(1)	18941400	181	61	179	44	72	57	35	0	17	0	0.25	0.41
368	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(5)	724256	7	7	7	3	3	3	0	0	1	0	0.25	0.41
369	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(5), ACAA1(2), ACAA2(1), ACADM(6), ACAT1(1), ACAT2(2), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(4), ALDH7A1(3), ALDH9A1(1), AOX1(8), AUH(1), BCAT1(1), BCAT2(1), BCKDHA(3), BCKDHB(1), DLD(1), ECHS1(2), EHHADH(2), HADH(1), HADHA(3), HADHB(2), HIBCH(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B10(2), HSD17B4(3), MCCC1(8), MCCC2(2), MCEE(2), MUT(4), OXCT1(3), OXCT2(1), PCCA(9), PCCB(4)	14612196	115	50	114	32	44	39	15	0	17	0	0.25	0.41
370	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(6), GOT2(1), TAT(5), TYR(3)	1578396	16	12	15	7	6	5	3	0	2	0	0.25	0.42
371	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(5), MTMR2(2), MTMR6(4), NFS1(2), PHPT1(1), THTPA(1), TPK1(3)	2155772	20	15	20	5	8	6	4	0	2	0	0.26	0.42
372	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(4), NFKB1(6), PLCB1(8), PRKCA(4), RELA(2)	2786092	24	16	24	9	10	6	3	1	4	0	0.26	0.43
373	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(4), MMP2(5), MMP9(11), RECK(5), TIMP1(2), TIMP2(2), TIMP3(3), TIMP4(2)	2546160	34	22	34	8	19	7	7	0	1	0	0.26	0.43
374	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG5(4), ATG7(1), BECN1(3), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNG(1), PIK3C3(7), PIK3R4(12), PRKAA1(3), PRKAA2(9), ULK1(1), ULK2(4), ULK3(3)	7033388	72	32	71	17	14	32	20	0	6	0	0.26	0.43
375	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), CA1(1), CA13(1), CA14(2), CA2(1), CA3(2), CA4(1), CA5A(2), CA6(2), CA8(3), CA9(2), CPS1(14), CTH(2), GLS2(2), GLUD1(2), GLUD2(6), GLUL(4), HAL(4)	7083264	52	30	52	26	20	17	6	0	9	0	0.26	0.43
376	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), MIOX(1), UGDH(4)	2871660	31	20	31	6	10	12	5	0	4	0	0.27	0.43
377	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(5), ALDH4A1(3), ALDH5A1(4), CAD(11), CPS1(14), EPRS(12), GAD1(9), GAD2(4), GCLC(4), GCLM(1), GFPT1(4), GLS2(2), GLUD1(2), GLUL(4), GMPS(5), GOT1(6), GOT2(1), GPT2(2), GSS(4), NADSYN1(2), PPAT(6), QARS(8)	11133376	113	44	112	23	36	39	26	2	10	0	0.27	0.43
378	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(3), CYSLTR2(4), GPR161(7), GPR171(4), GPR18(2), GPR34(6), GPR39(3), GPR45(7), GPR65(1), GPR75(2)	3322532	39	23	39	12	17	9	8	0	5	0	0.27	0.43
379	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(9), EGF(3), EGFR(11), TF(11), TFRC(3)	4321724	37	23	37	7	17	9	7	0	3	1	0.27	0.43
380	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(4), GLB1(3), HEXB(3), LCT(20), SLC33A1(2), ST3GAL1(1), ST3GAL2(1), ST6GALNAC3(4), ST6GALNAC4(2), ST6GALNAC5(6), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(6)	5547116	59	31	58	20	27	16	11	0	5	0	0.27	0.44
381	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(2), BIRC3(7), CASP8(11), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF2(1)	2786104	25	19	24	6	6	8	6	0	5	0	0.27	0.44
382	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1(1), BNIP1(1), GOSR1(3), GOSR2(3), SEC22B(3), SNAP23(1), SNAP25(1), SNAP29(3), STX11(2), STX12(3), STX16(3), STX17(1), STX18(1), STX19(2), STX2(3), STX3(3), STX4(2), STX5(3), STX6(1), STX7(3), STX8(4), TSNARE1(1), VAMP1(1), VAMP3(2), VAMP4(3), VAMP5(2), VAMP8(1), VTI1A(1), VTI1B(1), YKT6(1)	5513852	60	26	58	17	23	14	9	0	14	0	0.28	0.45
383	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(18), ACAT1(1), ACAT2(2), ACYP1(2), ADH5(1), AKR1B1(3), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), DLAT(3), DLD(1), GRHPR(1), LDHA(2), LDHB(3), LDHC(2), LDHD(1), MDH1(1), MDH2(1), ME1(9), ME2(3), ME3(5), PC(6), PCK1(3), PDHA1(5), PDHA2(8), PDHB(2), PKM2(2)	12416864	118	45	116	37	42	40	21	1	14	0	0.28	0.45
384	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(6), FOS(1), IKBKB(4), IRAK1(1), LY96(2), MAP2K3(6), MAP2K4(11), MAP2K6(3), MAP3K1(8), MAP3K14(3), MAP3K7(4), MAPK14(3), MAPK8(7), MYD88(2), NFKB1(6), PPARA(1), RELA(2), TIRAP(1), TLR10(4), TLR2(6), TLR3(5), TLR4(10), TLR6(2), TLR7(7), TLR9(7), TOLLIP(1), TRAF6(4)	12330284	118	43	117	34	38	36	29	3	11	1	0.28	0.45
385	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS2(2), GLUD1(2), GLUD2(6)	1449628	10	10	10	6	6	3	1	0	0	0	0.28	0.45
386	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CDC42(1), CREB1(1), DAXX(1), GRB2(3), HSPB2(2), MAP2K4(11), MAP2K6(3), MAP3K1(8), MAP3K5(6), MAP3K7(4), MAP3K9(4), MAPK14(3), MAPKAPK2(3), MAPKAPK5(1), MAX(1), MEF2A(4), MEF2C(9), MEF2D(1), MKNK1(1), PLA2G4A(8), RIPK1(2), RPS6KA5(6), SHC1(3), STAT1(6), TGFB1(1), TGFB2(9), TGFBR1(9), TRADD(1), TRAF2(1)	12479444	114	40	109	34	41	32	25	0	16	0	0.29	0.46
387	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(5), DNMT1(19), MTNR1B(3), PTAFR(1), PTGDR(1), PTGER2(1), PTGFR(7), PTGIR(1)	3740564	39	26	35	8	18	10	7	3	1	0	0.29	0.46
388	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(6), GNB1(1), GNGT1(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4)	3168296	26	22	26	7	11	9	4	0	2	0	0.30	0.47
389	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(6), ACAT1(1), ECHS1(2), HADHA(3)	1824120	14	9	13	5	2	4	1	0	7	0	0.30	0.47
390	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(15), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(6), ADIPOQ(4), ADIPOR1(1), ADIPOR2(3), AKT1(2), AKT2(6), AKT3(1), CAMKK1(1), CAMKK2(1), CD36(1), CHUK(6), CPT1A(6), CPT1B(5), CPT2(2), G6PC(4), G6PC2(1), IKBKB(4), IRS1(8), IRS4(15), JAK1(4), JAK2(9), JAK3(8), LEP(1), LEPR(9), MAPK10(8), MAPK8(7), MAPK9(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), NPY(2), PCK1(3), PCK2(3), POMC(2), PPARA(1), PPARGC1A(5), PRKAA1(3), PRKAA2(9), PRKAB1(2), PRKAB2(1), PRKAG1(1), PRKAG2(3), PRKAG3(6), PRKCQ(5), PTPN11(5), RELA(2), RXRA(1), RXRB(3), RXRG(4), SLC2A1(1), SLC2A4(4), STAT3(2), TNFRSF1A(1), TRADD(1), TRAF2(1), TYK2(1)	27776160	245	71	243	81	74	89	47	5	28	2	0.30	0.47
391	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(18), ACACB(15), ACAT1(1), ACAT2(2), ACOT12(9), ACSS1(3), ACSS2(6), ACYP1(2), AKR1B1(3), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), DLAT(3), DLD(1), GRHPR(1), LDHA(2), LDHAL6A(3), LDHAL6B(2), LDHB(3), LDHC(2), LDHD(1), MDH1(1), MDH2(1), ME1(9), ME2(3), ME3(5), PC(6), PCK1(3), PCK2(3), PDHA1(5), PDHA2(8), PDHB(2), PKM2(2)	15711112	151	50	149	45	52	54	23	2	20	0	0.30	0.47
392	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(3), ADCY3(2), ADCY9(6), ARF4(3), ARF6(1), ARL4D(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(9), ATP6V1A(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), ERO1L(2), GNAS(6), PDIA4(5), PLCG1(4), PLCG2(13), PRKCA(4), SEC61A1(5), SEC61A2(1), SEC61B(1), TRIM23(9)	12441852	107	49	100	32	50	26	21	1	9	0	0.30	0.47
393	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(4), ABAT(5), ACAT1(1), ACAT2(2), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH5A1(4), ALDH9A1(1), ECHS1(2), EHHADH(2), GAD1(9), GAD2(4), HADHA(3), HMGCL(1), L2HGDH(3), OXCT1(3), PDHA1(5), PDHA2(8), PDHB(2), SDHB(2), SDS(2)	8712916	95	41	94	25	36	36	15	0	8	0	0.30	0.47
394	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(6), GOT2(1), TAT(5)	882876	12	8	11	2	4	5	1	0	2	0	0.30	0.47
395	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA3(3), PSMA4(2), PSMA5(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(2), PSMB6(2), PSMC2(1), PSMC3(3), PSMD1(8), PSMD11(3), PSMD12(4), PSMD13(2), PSMD2(4), PSMD6(3)	5395420	44	25	43	15	15	14	9	2	4	0	0.30	0.48
396	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(1), DPYD(14), DPYS(7), ENPP1(4), ENPP3(4), PANK1(2), PANK3(3), PANK4(1), PPCS(2), UPB1(5)	4637728	44	24	43	13	9	21	9	0	5	0	0.31	0.48
397	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGT(5), AGTR1(5), AGTR2(5), BDKRB2(3), KNG1(4), NOS3(2), REN(5)	3308712	31	21	30	9	9	10	6	0	6	0	0.31	0.49
398	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(2), CPS1(14), GLUD1(2), GOT1(6)	2556608	25	14	24	6	6	9	4	0	6	0	0.32	0.49
399	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(2), CDK7(1), ERCC3(7), GTF2B(1), GTF2E1(5), GTF2F2(1), GTF2H1(4), GTF2H4(1), MNAT1(1), POLR1A(10), POLR1B(8), POLR2A(6), POLR2B(8), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLR3B(11), POLR3D(3), POLR3E(6), POLR3H(1), POLR3K(1), TAF5(4), TAF6(3), TAF7(2), TAF9(1), TBP(1)	11874536	92	44	92	26	33	31	17	1	10	0	0.32	0.49
400	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(18), ATP4B(1), ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), ATP7A(6), ATP7B(4), COX10(2), COX4I1(2), COX6A2(1), COX6C(1), COX7A1(1), NDUFA1(1), NDUFA10(2), NDUFA4(2), NDUFB2(1), NDUFB6(1), NDUFS1(6), NDUFS2(3), NDUFV1(2), PPA2(3), SDHA(6), SDHB(2), SHMT1(2), UQCRB(2), UQCRC1(2), UQCRFS1(1), UQCRH(1)	12311416	111	46	110	31	41	44	17	0	9	0	0.32	0.49
401	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(2), EHHADH(2), HADH(1), HADHA(3), HSD17B10(2), HSD17B4(3), NTAN1(3), SIRT1(5), SIRT2(2), SIRT5(3), SIRT7(1), VNN2(2)	3953912	29	21	29	12	9	7	5	0	8	0	0.32	0.49
402	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(5), PLCD1(7), PRKCA(4), TGM2(6)	1700380	22	14	22	6	9	11	1	0	1	0	0.32	0.49
403	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(8), GNAS(6), PLCE1(9), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RAP2B(1)	4839720	37	27	37	11	15	12	6	0	4	0	0.32	0.49
404	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(2), CD3D(1), CD3G(2), ICAM1(2), ITGAL(8), ITGB2(5), PTPRC(17)	3589836	40	21	40	14	9	16	7	0	8	0	0.33	0.49
405	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(2), GRIA2(13), PPP1R1B(1)	1277456	16	13	15	5	7	3	5	0	1	0	0.33	0.49
406	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS1(1), DHRS2(3), DHRS3(2), HSD3B7(2), PON1(6), PON2(2), PON3(2), RDH11(1), RDH12(3), RDH13(1)	2836156	23	18	23	10	10	7	2	0	4	0	0.33	0.49
407	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(2), ALOX5(4), CYP4F2(8), CYP4F3(3), EPX(7), GGT1(3), LPO(3), MPO(5), PLA2G1B(1), PLA2G4A(8), PLA2G6(4), PRDX1(1), PRDX6(2), PTGIS(5), PTGS1(6), PTGS2(3), TBXAS1(5), TPO(11)	9414848	83	43	79	30	42	25	8	2	6	0	0.33	0.50
408	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(5), IGF1(2), IL11(1), IL1A(1), IL3(3), IL6(2), IL9(2), KITLG(2), TGFB1(1), TGFB2(9)	2857640	28	18	27	13	9	11	4	0	4	0	0.33	0.50
409	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(12), ESR2(2), PDE1A(4), PDE1B(3), PLCB1(8), PLCB2(3), PRL(3), TRH(2)	3763900	37	22	37	11	14	11	6	2	4	0	0.34	0.51
410	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(5), AARS2(6), ABAT(5), ADSL(7), ADSS(2), AGXT2(5), ASL(2), ASNS(1), ASPA(5), ASS1(2), CAD(11), CRAT(3), DARS(4), DARS2(3), DDO(2), DLAT(3), DLD(1), GAD1(9), GAD2(4), GOT1(6), GOT2(1), GPT2(2), NARS(3), NARS2(6), PC(6), PDHA1(5), PDHA2(8), PDHB(2)	12804920	119	50	117	38	53	38	17	0	11	0	0.34	0.51
411	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(4), TPI1(1)	533176	5	5	5	0	0	2	3	0	0	0	0.34	0.51
412	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(2), CD3D(1), CD3G(2), CD4(2), ICAM1(2), ITGAL(8), ITGB2(5), PTPRC(17)	3788088	42	22	42	16	9	18	7	0	8	0	0.34	0.51
413	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(1), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), AOC2(4), AOC3(4), DDC(1), EPX(7), GOT1(6), GOT2(1), HPD(4), LPO(3), MAOA(3), MAOB(1), MPO(5), PRDX1(1), PRDX6(2), TAT(5), TPO(11)	7429544	71	41	69	26	35	22	8	0	6	0	0.34	0.51
414	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(6), EIF2B5(5), EIF2S2(1), EIF2S3(1), EIF5(3), GSK3B(8)	3896512	26	19	26	5	6	6	9	0	5	0	0.35	0.52
415	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CSF1(2), IL11(1), IL2(4), IL3(3), IL4(3), IL6(2), IL7(2), IL8(1), IL9(2)	2111556	22	14	21	8	9	10	2	0	1	0	0.35	0.52
416	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), BCAT2(1), COASY(1), DPYD(14), DPYS(7), ENPP1(4), ENPP3(4), ILVBL(2), PANK1(2), PANK3(3), PANK4(1), PPCS(2), UPB1(5), VNN1(6)	5802924	53	29	52	19	13	24	11	0	5	0	0.36	0.53
417	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(1), IFNG(1), IL10(2), IL12A(1), IL12B(2), IL13(1), IL15(1), IL16(9), IL1A(1), IL2(4), IL3(3), IL4(3), IL6(2), IL8(1), IL9(2)	3264776	35	20	34	20	13	17	3	0	2	0	0.36	0.53
418	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS1(1), DHRS2(3), DHRS3(2), ESCO1(11), ESCO2(4), MYST3(18), MYST4(10), PNPLA3(4), SH3GLB1(4)	5363104	57	27	56	17	24	14	13	1	5	0	0.36	0.53
419	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(2), ALOX12B(2), ALOX15B(5), ALOX5(4), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2J2(3), CYP2U1(1), CYP4A11(3), CYP4A22(2), CYP4F2(8), CYP4F3(3), EPHX2(1), GGT1(3), GPX1(1), GPX2(2), GPX3(3), GPX5(4), GPX6(3), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PTGIS(5), PTGS1(6), PTGS2(3), TBXAS1(5)	13247308	108	51	105	38	41	39	19	2	7	0	0.36	0.54
420	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(3), CARM1(2), CBS(3), CTH(2), GGT1(3), LCMT1(3), LCMT2(2), MARS(6), MARS2(1), MAT1A(5), MAT2B(3), METTL2B(2), METTL6(8), PAPSS1(2), PAPSS2(4), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), SCLY(1), SEPHS1(3), SEPHS2(3), WBSCR22(1)	8378796	71	38	67	22	23	27	12	2	7	0	0.37	0.54
421	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(3), GGT1(3), SHMT1(2), SHMT2(2)	1456228	10	10	8	5	2	5	0	0	3	0	0.37	0.55
422	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(5), GPD2(4), NDUFA1(1), SDHA(6), SDHB(2), SDHD(1), UQCRC1(2)	2201480	21	15	21	3	6	11	3	0	1	0	0.38	0.55
423	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(1), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), AOC2(4), AOC3(4), DDC(1), EPX(7), ESCO1(11), ESCO2(4), GOT1(6), GOT2(1), HPD(4), LPO(3), MAOA(3), MAOB(1), MPO(5), MYST3(18), MYST4(10), PNPLA3(4), PRDX6(2), SH3GLB1(4), TAT(5), TPO(11)	11521728	121	49	118	38	55	36	21	1	8	0	0.38	0.55
424	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(4), JAK2(9), JAK3(8), MAPK1(2), MAPK3(3), STAT3(2), TYK2(1)	4021052	29	20	28	10	9	9	4	0	5	2	0.39	0.56
425	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(3), CAMK1G(5), HDAC9(13), MEF2A(4), MEF2C(9), MEF2D(1), YWHAH(1)	2816904	36	18	36	15	9	14	10	0	3	0	0.39	0.56
426	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP1(1), RANBP2(16), RANGAP1(1)	2797624	20	12	19	4	5	5	6	0	4	0	0.39	0.56
427	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(1), ACY1(2), ADC(1), AGMAT(4), ALDH18A1(5), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), AMD1(1), AOC2(4), AOC3(4), ARG1(1), ARG2(5), ASL(2), ASS1(2), CPS1(14), GATM(1), MAOA(3), MAOB(1), NAGS(1), ODC1(5), OTC(5), SAT1(4), SAT2(2), SMS(2)	10020960	96	40	93	30	31	36	16	0	13	0	0.39	0.57
428	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(8), CKM(5), FBL(3), LDHA(2), LDHB(3), LDHC(2), MAPK14(3), NCL(3)	2992944	29	21	29	14	12	12	4	0	1	0	0.40	0.57
429	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), ADRBK2(2), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CLCA1(6), CLCA2(7), CLCA4(6), CNGA3(6), CNGA4(6), CNGB1(7), GNAL(4), GUCA1A(2), GUCA1B(3), GUCA1C(1), PDC(2), PDE1C(9), PRKACA(1), PRKACB(1), PRKACG(3), PRKG1(9), PRKG2(5), PRKX(2)	10394224	92	38	90	41	28	38	15	1	10	0	0.40	0.57
430	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), GUSB(2), RPE(2), UCHL1(2), UCHL3(2), UGDH(4), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2B15(2), UGT2B4(3)	5467492	39	22	39	11	15	14	3	0	7	0	0.40	0.57
431	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(11), ABCC2(14), ABCG2(9), BCHE(9), CES1(5), CES2(1), CYP3A4(1), CYP3A5(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6)	7656476	72	30	72	21	26	19	18	1	8	0	0.40	0.57
432	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(4), IL13(1), IL4(3), MAF(1), MAP2K3(6), MAPK14(3), NFATC1(2), NFATC2(5), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3)	3873292	38	26	38	11	21	8	4	2	3	0	0.41	0.58
433	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(2), DHRS1(1), DHRS2(3), DHRS3(2), LCMT1(3), LCMT2(2), METTL2B(2), METTL6(8), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), WBSCR22(1)	4834036	38	24	37	15	13	10	7	2	6	0	0.41	0.58
434	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG1(1), ARG2(5), ASL(2), ASS1(2), CKM(5), CKMT1B(1), CKMT2(5), CPS1(14), DAO(6), EPRS(12), GAMT(1), GATM(1), GLUD1(2), GLUD2(6), GOT1(6), GOT2(1), LAP3(2), NOS1(11), NOS3(2), OAT(1), OTC(5), P4HA1(1), P4HA2(2), P4HA3(2), RARS(4), RARS2(5)	11973188	108	41	107	37	35	35	20	1	17	0	0.41	0.58
435	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(7), APOBEC1(2), APOBEC2(1), APOBEC3A(1), APOBEC3C(3), APOBEC3F(2), APOBEC3G(3), APOBEC4(4)	2471012	23	16	23	5	9	8	3	1	2	0	0.41	0.58
436	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(2), ACOX1(3), ACOX3(7), ELOVL2(3), ELOVL5(1), ELOVL6(1), FADS2(4), FASN(1), HADHA(3), HSD17B12(2), SCD(2)	4616912	29	23	29	10	13	7	4	1	4	0	0.41	0.58
437	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(10), AZIN1(2), BTG1(1), CBX3(3), CLOCK(8), CRY1(5), CRY2(1), DNAJA1(2), EIF4G2(7), ETV6(5), GFRA1(8), GSTM3(3), HERPUD1(1), HSPA8(4), IDI1(1), MYF6(2), NCKAP1(9), NCOA4(4), NR1D2(6), PER1(1), PER2(2), PPP1R3C(4), PPP2CB(2), PSMA4(2), SF3A3(1), SUMO3(1), TOB1(2), TUBB3(2), UCP3(2), UGP2(7), ZFR(6)	12361876	114	40	110	22	38	33	27	1	14	1	0.41	0.58
438	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(3), CHRNA1(4), SNAP25(1), STX1A(2)	1094156	10	10	10	4	6	2	2	0	0	0	0.41	0.58
439	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), DAG1(5), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), NFAT5(5), PDE6A(7), PDE6B(5), PDE6C(10), PDE6D(1), SLC6A13(6), TF(11)	12253428	111	44	111	27	44	34	21	0	11	1	0.41	0.58
440	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	16	ABCA1(22), APOC1(1), APOC2(1), APOE(1), CETP(7), CYP7A1(4), HMGCR(3), LCAT(1), LDLR(5), LIPC(4), LPL(6), LRP1(17), SCARB1(1), SOAT1(1)	8566096	74	36	74	23	31	23	13	1	6	0	0.41	0.58
441	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(5), GALNS(4), GLB1(3), GNS(4), GUSB(2), HEXB(3), HGSNAT(6), HPSE(2), HPSE2(12), IDS(2), IDUA(1), LCT(20), NAGLU(4), SPAM1(4)	6988988	72	32	70	19	28	20	15	1	8	0	0.42	0.58
442	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(1), CAD(11), CDA(1), CTPS(4), CTPS2(4), DCK(2), DCTD(3), DHODH(4), DPYD(14), DPYS(7), DTYMK(1), ENTPD1(2), ITPA(2), NT5E(3), NT5M(1), POLB(3), POLD1(5), POLD2(1), POLE(21), POLG(5), POLL(1), POLQ(12), POLR1B(8), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLRMT(1), RRM1(2), RRM2(2), TK1(1), TK2(1), TXNRD1(3), TYMS(3), UCK2(1), UMPS(1), UNG(1), UPB1(5)	19482744	156	60	153	42	47	59	33	1	16	0	0.42	0.58
443	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(2), DLAT(3), DLD(1), DLST(1), FH(1), IDH2(7), IDH3A(4), IDH3G(2), MDH1(1), MDH2(1), OGDH(4), PC(6), PDHA1(5), PDHA2(8), PDHB(2), PDHX(2), PDK1(2), PDK2(2), PDK3(1), PDK4(3), PDP2(1), SDHA(6), SDHB(2), SDHD(1), SUCLA2(5), SUCLG1(2)	9641104	75	37	74	28	32	20	11	0	12	0	0.43	0.59
444	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(10), POLR1B(8), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(11), POLR3GL(1), POLR3H(1), POLR3K(1)	7851096	66	36	66	12	25	24	12	1	4	0	0.43	0.59
445	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(2), IL6(2), LDLR(5), LPL(6)	1784860	16	12	16	4	6	4	4	0	2	0	0.43	0.60
446	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(5), CSF1R(3), EGF(3), EGFR(11), GRB2(3), MET(5), PDGFRA(17), PRKCA(4), SH3GLB1(4), SH3GLB2(2), SH3KBP1(4), SRC(3)	6577212	64	28	64	29	20	24	15	0	4	1	0.44	0.61
447	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(3), IFNGR2(2), JAK1(4), JAK2(9), STAT1(6)	2773344	25	15	24	7	8	6	6	0	3	2	0.45	0.61
448	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(5), CHIT1(5), CMAS(8), CTBS(4), CYB5R1(3), CYB5R3(1), GFPT1(4), GFPT2(4), GNE(2), GNPDA2(1), HEXB(3), HK1(6), HK2(3), HK3(5), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(4), NAGK(2), NANS(1), NPL(3), PGM3(5), PHPT1(1), RENBP(1)	9678628	80	41	79	24	32	27	14	1	6	0	0.46	0.63
449	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(5), GALNS(4), GLB1(3), GNS(4), GUSB(2), HEXB(3), IDS(2), IDUA(1), LCT(20), NAGLU(4)	4901776	48	27	48	13	21	12	10	0	5	0	0.46	0.63
450	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(1), FOS(1), FYN(5), MAPK14(3), THBS1(10)	2470356	22	16	22	8	7	10	3	0	2	0	0.47	0.64
451	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT1(2), AGPAT3(3), AGPAT4(8), AGPS(3), CDS1(2), CDS2(4), CHAT(6), CHKA(4), CLC(3), CPT1B(5), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKZ(3), ETNK1(2), GNPAT(2), GPD1(1), GPD2(4), LCAT(1), PAFAH1B1(3), PAFAH2(1), PCYT1A(5), PCYT1B(5), PEMT(1), PISD(2), PLA2G1B(1), PLA2G4A(8), PLA2G6(4), PLCB2(3), PLCG1(4), PLCG2(13), PPAP2B(1)	16943328	144	54	139	55	58	40	29	0	17	0	0.47	0.64
452	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(3), ESR1(12), GREB1(12), HSPB2(2), MTA1(1), MTA3(1), PDZK1(1), TUBA8(2)	3616560	35	21	35	10	12	11	6	1	5	0	0.47	0.65
453	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(8), BCL2(1), CASP3(2), CASP9(2), DAXX(1), FAS(2), FASLG(1), HSPB2(2), IL1A(1), MAPKAPK2(3), MAPKAPK3(1)	3763944	28	20	28	11	7	11	6	0	4	0	0.48	0.65
454	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(3), ACOX3(7), FADS2(4), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4)	3482308	28	18	27	9	14	4	6	1	3	0	0.48	0.65
455	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(6), ATIC(4), DHFR(1), FTCD(2), GART(3), MTFMT(2), MTHFD1(6), MTHFD1L(8), MTHFR(7), MTHFS(1), MTR(7), SHMT1(2), SHMT2(2), TYMS(3)	6387856	54	30	53	15	22	18	7	1	6	0	0.49	0.66
456	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(3), ACSS2(6), ACYP1(2), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH7A1(3), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(3), DLAT(3), DLD(1), ENO2(3), ENO3(4), FBP2(3), G6PC(4), G6PC2(1), GALM(2), GCK(2), GPI(2), HK1(6), HK2(3), HK3(5), LDHA(2), LDHAL6A(3), LDHAL6B(2), LDHB(3), LDHC(2), PDHA1(5), PDHA2(8), PDHB(2), PFKL(1), PFKM(4), PFKP(2), PGAM1(3), PGAM2(1), PGK1(3), PGK2(7), PGM1(4), PGM3(5), PKM2(2), TPI1(1)	19321516	174	59	172	58	57	68	36	1	12	0	0.49	0.66
457	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(3), ABP1(1), AOC2(4), AOC3(4), CES1(5), CES7(1), DDHD1(3), ESCO1(11), ESCO2(4), LIPA(1), MYST3(18), MYST4(10), PLA1A(3), PNPLA3(4), PPME1(2), PRDX6(2), SH3GLB1(4)	8536896	80	35	79	27	31	24	17	1	7	0	0.49	0.66
458	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(3), AASS(9), ACAT1(1), ACAT2(2), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), BBOX1(3), DLST(1), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(2), EHMT2(3), GCDH(5), HADH(1), HADHA(3), HSD17B10(2), HSD17B4(3), HSD3B7(2), NSD1(14), OGDH(4), OGDHL(11), PIPOX(4), PLOD1(4), PLOD2(5), PLOD3(4), RDH11(1), RDH12(3), RDH13(1), SETD1A(8), SETD7(3), SETDB1(8), SHMT1(2), SHMT2(2), SPCS1(1), SPCS3(1), SUV39H1(1), SUV39H2(3), TMLHE(3)	19406496	157	55	154	43	63	40	29	2	23	0	0.50	0.67
459	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(1), AGXT2(5), ALAS1(6), ALAS2(6), AOC2(4), AOC3(4), BHMT(5), CBS(3), CHDH(2), CHKA(4), CPT1B(5), CTH(2), DAO(6), DLD(1), DMGDH(7), GAMT(1), GARS(3), GATM(1), GCAT(1), GLDC(3), MAOA(3), MAOB(1), PEMT(1), PISD(2), PLCB2(3), PLCG1(4), PLCG2(13), SARDH(8), SARS(2), SHMT1(2), SHMT2(2), TARS(6)	14310036	117	49	115	43	52	39	12	0	14	0	0.50	0.67
460	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(1), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH9A1(1), AOC2(4), AOC3(4), ASPA(5), CNDP1(3), DDC(1), HAL(4), HARS(2), HDC(8), HNMT(4), MAOA(3), MAOB(1), PRPS1(1), PRPS2(2)	8248076	80	40	80	27	31	30	16	0	3	0	0.51	0.68
461	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(1), IL12A(1), IL12B(2), IL2(4)	1022608	10	7	10	6	0	10	0	0	0	0	0.51	0.68
462	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(3), ACTR2(2), ACTR3(3), AKT1(2), ANGPTL2(8), CDC42(1), CFL1(1), FLNA(3), FLNC(13), FSCN3(2), GDI1(1), GDI2(1), LIMK1(5), MYH2(12), MYLK(14), MYLK2(3), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PFN2(1), RHO(3), ROCK1(15), ROCK2(6), RPS4X(2), VASP(3), WASF1(3), WASL(7)	16002580	135	53	135	37	45	45	23	1	21	0	0.52	0.70
463	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(8), C9orf95(1), CD38(2), ENPP1(4), ENPP3(4), NADK(2), NADSYN1(2), NMNAT1(2), NMNAT2(2), NMNAT3(2), NNMT(3), NNT(3), NT5C1A(1), NT5C1B(10), NT5C2(4), NT5C3(2), NT5E(3), NT5M(1), NUDT12(2), QPRT(1)	7314932	59	32	59	24	20	20	11	0	8	0	0.53	0.70
464	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), ST6GALNAC2(2), ST6GALNAC4(2), ST8SIA1(3)	1894452	12	11	12	4	2	3	5	0	2	0	0.54	0.71
465	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), SHMT1(2)	5125316	40	25	39	10	14	14	8	0	4	0	0.54	0.71
466	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), SHMT1(2)	5125316	40	25	39	10	14	14	8	0	4	0	0.54	0.71
467	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), SHMT1(2)	5125316	40	25	39	10	14	14	8	0	4	0	0.54	0.71
468	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCR5(1), CXCL12(1), CXCR4(4), FOS(1), GNAQ(4), MAPK14(3), MAPK8(7), PLCG1(4), PRKCA(4), PTK2B(1), SYT1(1)	4495712	31	22	32	12	9	11	5	1	5	0	0.54	0.71
469	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(2), NDUFA4(2), NDUFB2(1), NDUFB6(1), NDUFS1(6), NDUFS2(3), NDUFV1(2)	2338256	18	14	18	6	7	6	3	0	2	0	0.54	0.71
470	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(2), ITGA4(8), ITGAL(8), ITGB1(6), ITGB2(5), PECAM1(2), SELE(4), SELL(3)	4417984	41	22	39	11	9	19	9	0	4	0	0.55	0.72
471	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(6), CARM1(2), CREBBP(25), EP300(15), ERCC3(7), ESR1(12), GRIP1(8), GTF2A1(2), GTF2E1(5), GTF2F1(5), HDAC1(2), HDAC2(2), HDAC3(2), HDAC4(5), HDAC5(2), HDAC6(6), MEF2C(9), NCOR2(2), NR0B1(3), NRIP1(6), PELP1(2), POLR2A(6), TBP(1)	15980772	135	50	134	32	52	35	29	4	15	0	0.55	0.72
472	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(5), CDKN1A(1), GRIN1(1), HIF1A(3), JAK2(9), NFKB1(6), RELA(2), SOD2(4)	4318920	31	20	31	9	10	9	5	0	5	2	0.55	0.72
473	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(2), ITGA4(8), ITGAL(8), ITGAM(8), ITGB1(6), ITGB2(5), PECAM1(2), SELE(4), SELL(3), SELP(6)	5770408	55	26	53	16	15	24	10	0	6	0	0.55	0.72
474	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1), CD3G(2)	387336	3	2	3	1	1	1	0	0	1	0	0.55	0.72
475	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(4), CYP1A2(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2J2(3), CYP3A4(1), CYP3A43(2), CYP3A5(3), CYP3A7(6), HSD3B7(2), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), RDH11(1), RDH12(3), RDH13(1)	8076436	66	31	65	28	26	19	16	0	4	1	0.55	0.72
476	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(1), AOC2(4), AOC3(4), CES1(5), ESD(1)	1980104	15	14	15	9	6	7	2	0	0	0	0.55	0.72
477	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(2), AKT2(6), AKT3(1), DAG1(5), GNAQ(4), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PDK1(2), PHKA2(6), PIK3CB(2), PITX2(2), PLD1(11), PLD2(2), PLD3(5), VN1R1(4)	15142744	119	46	119	40	50	35	18	2	13	1	0.56	0.72
478	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(4), FOS(1), MAPK3(3), OPRK1(5), POLR2A(6), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3)	4266716	33	23	33	8	16	7	6	1	3	0	0.56	0.72
479	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), ACAT2(2), HMGCL(1), OXCT1(3)	1135008	7	7	7	3	2	4	1	0	0	0	0.56	0.72
480	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(3), DLAT(3), DLD(1), ENO2(3), ENO3(4), FBP2(3), G6PC(4), GCK(2), GPI(2), HK1(6), HK2(3), HK3(5), LDHA(2), LDHB(3), LDHC(2), PDHA1(5), PDHA2(8), PDHB(2), PFKM(4), PFKP(2), PGAM1(3), PGK1(3), PGM1(4), PGM3(5), PKM2(2), TPI1(1)	16298620	154	54	152	49	51	58	35	0	10	0	0.56	0.72
481	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(3), DLAT(3), DLD(1), ENO2(3), ENO3(4), FBP2(3), G6PC(4), GCK(2), GPI(2), HK1(6), HK2(3), HK3(5), LDHA(2), LDHB(3), LDHC(2), PDHA1(5), PDHA2(8), PDHB(2), PFKM(4), PFKP(2), PGAM1(3), PGK1(3), PGM1(4), PGM3(5), PKM2(2), TPI1(1)	16298620	154	54	152	49	51	58	35	0	10	0	0.56	0.72
482	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(1), EEF1B2(1), EEF1G(1), EEF2(3), EEF2K(1), EIF2AK1(6), EIF2AK2(1), EIF2AK3(2), EIF2B1(2), EIF2B2(1), EIF2B3(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), EIF4A2(5), EIF4EBP2(1), EIF4G1(9), EIF4G3(11), EIF5(3), EIF5A(2), EIF5B(4), ETF1(5), KIAA0664(4), PABPC1(3), PABPC3(6), PAIP1(4), SLC35A4(2)	14923252	87	44	85	25	26	20	22	5	14	0	0.57	0.73
483	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDC25B(5), CDK7(1), CDKN1A(1), CHEK1(1), NEK1(9), WEE1(3)	2529196	22	14	21	7	7	8	4	2	1	0	0.57	0.73
484	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACAA1(2), ACADL(2), ACADM(6), ACOX1(3), ACOX2(2), ACOX3(7), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(6), ADIPOQ(4), APOA2(1), APOA5(1), AQP7(1), CD36(1), CPT1A(6), CPT1B(5), CPT2(2), CYP27A1(3), CYP4A11(3), CYP4A22(2), CYP7A1(4), CYP8B1(3), EHHADH(2), FABP1(1), FABP2(2), FABP3(1), FABP4(1), FABP5(1), FABP6(1), FABP7(1), FADS2(4), GK(3), GK2(6), HMGCS2(1), LPL(6), ME1(9), MMP1(2), NR1H3(4), OLR1(2), PCK1(3), PCK2(3), PDPK1(1), PLTP(7), PPARA(1), PPARD(2), PPARG(1), RXRA(1), RXRB(3), RXRG(4), SCD(2), SCP2(3), SLC27A1(2), SLC27A2(3), SLC27A4(1), SLC27A5(4), SLC27A6(9), SORBS1(11), UCP1(1)	21740648	190	62	187	59	59	71	34	6	20	0	0.57	0.73
485	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(1), ACAT2(2), ACOT11(3), ACYP1(2), DHRS1(1), DHRS2(3), DHRS3(2), ECHS1(2), EHHADH(2), ESCO1(11), ESCO2(4), GCDH(5), HADHA(3), ITGB1BP3(1), MYST3(18), MYST4(10), PNPLA3(4), SH3GLB1(4), YOD1(1)	8546528	79	35	78	23	31	21	15	2	10	0	0.58	0.73
486	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(2), ACAA2(1), ACADL(2), ACADM(6), ACADSB(5), ACADVL(1), ACAT1(1), ACAT2(2), ACOX1(3), ACOX3(7), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(6), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), CPT1A(6), CPT1B(5), CPT2(2), CYP4A11(3), CYP4A22(2), ECHS1(2), EHHADH(2), GCDH(5), HADH(1), HADHA(3), HADHB(2), HSD17B10(2), HSD17B4(3), PECI(1)	16484772	143	48	142	45	39	48	35	4	17	0	0.58	0.73
487	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), GRB2(3), IL4(3), IL4R(1), IRS1(8), JAK1(4), JAK3(8), RPS6KB1(3), SHC1(3), STAT6(2)	4961496	37	24	35	12	11	14	5	0	7	0	0.59	0.74
488	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA3(3), PSMA4(2), PSMA5(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(2), PSMB6(2), PSMC3(3), PSMD14(1), RPN2(1), UBE2A(2), UBE3A(11)	4398832	34	18	34	12	10	11	9	1	3	0	0.59	0.74
489	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), ACAT2(2), ACYP1(2), ECHS1(2), EHHADH(2), GCDH(5), HADHA(3), SDHB(2), SDS(2)	2645360	21	13	21	3	6	7	2	1	5	0	0.59	0.74
490	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(2), ARPC2(2), CDC42(1), WASF1(3), WASL(7)	2755360	29	17	29	6	11	9	6	0	3	0	0.60	0.75
491	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(1), GSS(4), IL8(1), NFKB1(6), NOX1(1), RELA(2), XDH(7)	3343964	23	16	23	8	8	6	6	0	3	0	0.60	0.75
492	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(3), IFNAR2(2), IFNB1(1), JAK1(4), STAT1(6), STAT2(7), TYK2(1)	3630512	25	18	24	6	11	6	5	0	3	0	0.61	0.76
493	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(3), COQ6(2), COQ7(1), NDUFA12(2), NDUFA13(1)	1402476	9	8	9	2	1	4	2	0	2	0	0.61	0.76
494	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(4), FOS(1), GRB2(3), IL2(4), IL2RA(2), IL2RB(2), JAK1(4), JAK3(8), LCK(3), MAP2K1(4), MAPK3(3), MAPK8(7), RAF1(6), SHC1(3), SOS1(7), STAT5B(3), SYK(3)	7957296	67	33	64	19	19	27	12	1	8	0	0.61	0.76
495	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(6), ACADVL(1), ACSL1(3), ACSL3(6), ACSL4(4), CPT1A(6), CPT2(2), EHHADH(2), HADHA(3), SCP2(3), SLC25A20(2)	5661168	40	22	39	14	11	14	8	0	7	0	0.61	0.76
496	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(5), ARG1(1), ARG2(5), ASL(2), CKM(5), CKMT1B(1), CKMT2(5), CPS1(14), GAMT(1), GATM(1), GLUD1(2), NAGS(1), OAT(1), ODC1(5), OTC(5), SMS(2)	5843016	58	26	58	18	19	20	9	0	10	0	0.62	0.77
497	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(8), BCL2(1), BID(1), BIRC2(4), BIRC3(7), CASP10(2), CASP3(2), CASP6(2), CASP7(1), CASP8(11), CASP9(2), CFLAR(3), CHUK(6), DFFA(3), DFFB(2), GAS2(2), MAP3K14(3), NFKB1(6), RELA(2), RIPK1(2), SPTAN1(13), TNFRSF10A(3), TNFRSF10B(6), TNFSF10(1), TNFSF12(2), TRADD(1), TRAF2(1)	11388192	97	41	96	33	33	34	16	0	13	1	0.62	0.77
498	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(2), ITGAL(8), ITGAM(8), ITGB2(5), PECAM1(2), SELE(4), SELL(3)	3904096	35	21	35	10	10	16	5	0	4	0	0.62	0.77
499	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(2), CD3D(1), CD3G(2), CD4(2)	949080	8	7	9	5	3	4	0	0	1	0	0.62	0.77
500	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(6), ATIC(4), DHFR(1), GART(3), MTHFD1(6), MTHFD1L(8), MTHFR(7), MTHFS(1), MTR(7), SHMT1(2), SHMT2(2), TYMS(3)	6058280	50	28	49	14	21	17	7	1	4	0	0.63	0.78
501	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1)	2697372	33	19	33	5	13	12	7	0	1	0	0.63	0.78
502	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1)	2697372	33	19	33	5	13	12	7	0	1	0	0.63	0.78
503	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(6), DUSP1(2), IKBKAP(2), IKBKB(4), MAP3K1(8), MAP3K14(3), NFKB1(6), RELA(2), TNFAIP3(3), TRAF3(6), TRAF6(4)	6191184	46	25	46	16	20	13	6	1	6	0	0.63	0.78
504	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(1), AGXT2(5), ALAS1(6), ALAS2(6), AOC2(4), AOC3(4), BHMT(5), CBS(3), CHDH(2), CHKA(4), CTH(2), DAO(6), DLD(1), DMGDH(7), GAMT(1), GARS(3), GATM(1), GCAT(1), GLDC(3), GNMT(1), HSD3B7(2), MAOA(3), MAOB(1), PEMT(1), PHGDH(2), PIPOX(4), PISD(2), PSAT1(4), RDH11(1), RDH12(3), RDH13(1), SARDH(8), SARS(2), SARS2(2), SDS(2), SHMT1(2), SHMT2(2), TARS(6), TARS2(5)	14581668	119	47	119	45	48	44	14	0	13	0	0.64	0.78
505	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(2), ACAA2(1), ACAT1(1), ACAT2(2), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2), SDS(2)	2829676	17	13	17	7	3	8	2	0	4	0	0.64	0.78
506	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(6), HK2(3), HK3(5), IMPA1(2), IMPA2(2), PGM1(4), PGM3(5), TGDS(1)	3892472	30	22	30	12	10	15	4	0	1	0	0.64	0.78
507	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(7), DLL1(4), FURIN(3), PSEN1(3)	2877556	17	13	17	3	7	2	2	0	6	0	0.64	0.78
508	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(4), PGLYRP2(2)	615540	6	5	6	2	2	2	1	0	1	0	0.64	0.78
509	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(6), ALAS2(6), CPOX(1), FECH(3), HMBS(2), PPOX(3), UROD(1), UROS(1)	2600832	24	15	24	5	13	8	2	0	1	0	0.65	0.78
510	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(8), PNPO(1), PSAT1(4)	1634620	13	9	13	5	4	5	2	0	2	0	0.65	0.78
511	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(10), CLOCK(8), CRY1(5), CRY2(1), CSNK1D(4), NPAS2(5), NR1D1(4), PER1(1), PER2(2), PER3(9)	5763680	49	27	47	9	20	13	8	2	5	1	0.65	0.78
512	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), FDXR(1), SHMT1(2)	5431384	41	25	40	11	14	15	8	0	4	0	0.65	0.78
513	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(2), IFNAR1(3), IFNAR2(2), IFNB1(1), MAPK8(7), NFKB1(6), RELA(2), TNFRSF11A(3), TNFSF11(1), TRAF6(4)	3708116	32	17	32	10	12	9	5	1	5	0	0.65	0.79
514	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), ACO2(2), GRHPR(1), HAO1(5), HAO2(4), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(8)	4322352	33	21	32	13	12	11	5	2	3	0	0.66	0.79
515	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA1(1), CA14(2), CA2(1), CA3(2), CA4(1), CA5A(2), CA6(2), CA8(3), CA9(2), CPS1(14), CTH(2), GLS2(2), GLUD1(2), GLUL(4), HAL(4)	6325556	45	23	45	23	17	15	5	0	8	0	0.66	0.79
516	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(2), B3GALT1(1), B3GALT2(3), B3GALT5(4), B3GNT5(1), FUT1(4), FUT2(1), FUT3(4), ST3GAL3(4), ST3GAL4(2)	2414396	26	16	26	5	13	7	4	0	2	0	0.66	0.79
517	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(2), IL8(1)	570136	3	3	3	3	0	2	0	0	1	0	0.66	0.79
518	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(3), SDS(2)	4118656	42	23	42	8	16	14	7	0	5	0	0.66	0.79
519	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(3), CBS(3), CTH(2), GGT1(3), MARS(6), MARS2(1), MAT1A(5), MAT2B(3), PAPSS1(2), PAPSS2(4), SCLY(1), SEPHS1(3)	4172492	36	21	33	11	13	15	5	0	3	0	0.66	0.79
520	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA3(3), GGT1(3), SHMT1(2), SHMT2(2)	1946048	10	10	8	8	2	5	0	0	3	0	0.67	0.79
521	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(6), HK2(3), HK3(5), IMPA1(2), PGM1(4), PGM3(5), TGDS(1)	3425600	28	20	28	12	9	15	4	0	0	0	0.67	0.79
522	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(5), GPI(2), HK1(6), PFKL(1), PGAM1(3), PGK1(3), TPI1(1)	2944848	21	20	20	14	9	7	5	0	0	0	0.67	0.79
523	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(4), CYP11B2(5), CYP17A1(2), HSD11B1(1), HSD3B1(3), HSD3B2(1)	2321788	17	13	17	8	7	7	2	0	1	0	0.67	0.79
524	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(2), HMOX1(2), IL10(2), IL10RA(2), IL10RB(5), IL1A(1), IL6(2), JAK1(4), STAT1(6), STAT3(2)	4071596	30	19	27	18	12	8	7	0	3	0	0.68	0.79
525	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(6), IFNA1(1), IFNB1(1), IKBKB(4), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(1), IL1RN(3), IL6(2), IRAK1(1), IRAK2(8), IRAK3(3), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAP3K14(3), MAP3K7(4), MAPK14(3), MAPK8(7), MYD88(2), NFKB1(6), RELA(2), TGFB1(1), TGFB2(9), TOLLIP(1), TRAF6(4)	9990076	95	34	94	24	36	29	17	3	10	0	0.68	0.79
526	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(4), PRKCA(4), PTK2B(1)	2269828	12	11	12	5	6	3	2	0	1	0	0.68	0.80
527	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), ACO2(2), AFMID(1), GRHPR(1), HAO1(5), HAO2(4), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(8)	4532648	34	22	33	13	13	11	5	2	3	0	0.69	0.80
528	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15B(5), ALOX5(4), ALOX5AP(1), DPEP1(1), GGT1(3), PLA2G6(4), PTGIS(5), PTGS1(6), PTGS2(3), TBXAS1(5)	5098616	39	27	37	11	15	16	6	1	1	0	0.69	0.80
529	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(5), FUCA1(3), GLB1(3), HEXB(3), LCT(20), MAN2C1(6), MANBA(7), NEU1(1), NEU2(1), NEU3(1)	5527960	50	28	50	15	20	12	14	0	4	0	0.69	0.80
530	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(5), ASPH(3), COPS5(1), CREB1(1), EDN1(1), EP300(15), HIF1A(3), LDHA(2), NOS3(2), P4HB(2), VHL(1)	5609492	36	24	36	11	12	7	12	1	4	0	0.69	0.81
531	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(3), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), CYP2C19(4), CYP2C9(7), DHRS1(1), DHRS2(3), DHRS3(2), ECHS1(2), EHHADH(2), ESCO1(11), ESCO2(4), HADHA(3), MYST3(18), MYST4(10), PNPLA3(4), SH3GLB1(4), YOD1(1)	10243836	105	36	104	28	40	31	22	1	11	0	0.70	0.81
532	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(3), CDK2(2), DIAPH2(12), GMNN(1), MCM10(8), MCM3(3), MCM4(4), MCM5(6), MCM6(4), MCM7(3), NACA(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(3), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(21), POLE2(1), RFC1(14), RFC4(3), RFC5(3), RPA1(2), RPA2(1), RPA4(3), UBA52(2), UBB(2)	17190508	121	47	118	29	29	55	20	1	16	0	0.70	0.81
533	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(3), CSF1(2), FCGR3A(1), IL1B(1), IL6R(3), SELL(3), SPN(2), TGFB1(1), TGFB2(9), TNFRSF1A(1), TNFRSF8(2), TNFSF8(1)	4625192	31	18	31	14	8	11	5	0	7	0	0.70	0.81
534	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(4), AADAC(3), ABAT(5), ACAT1(1), ACAT2(2), ACSM1(5), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH5A1(4), ALDH7A1(3), ALDH9A1(1), BDH1(1), DDHD1(3), ECHS1(2), EHHADH(2), GAD1(9), GAD2(4), HADH(1), HADHA(3), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B10(2), HSD17B4(3), HSD3B7(2), ILVBL(2), L2HGDH(3), OXCT1(3), OXCT2(1), PDHA1(5), PDHA2(8), PDHB(2), PLA1A(3), PPME1(2), PRDX6(2), RDH11(1), RDH12(3), RDH13(1)	13826240	121	45	120	42	49	41	18	0	13	0	0.70	0.81
535	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), B4GALT1(6), B4GALT2(3), FBP2(3), G6PC(4), GALE(1), GALK2(3), GALT(2), GANAB(4), GCK(2), GLA(4), GLB1(3), HK1(6), HK2(3), HK3(5), LALBA(1), LCT(20), MGAM(13), PFKM(4), PFKP(2), PGM1(4), PGM3(5)	11029324	101	45	101	34	45	35	18	0	3	0	0.72	0.82
536	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(3), DAG1(5), GNAQ(4), ITPKB(4)	2002588	16	11	16	6	5	4	4	0	3	0	0.72	0.83
537	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(6), EGR2(8), EGR3(2), GNAQ(4), MAP3K1(8), NFATC1(2), NFATC2(5), NFKB1(6), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RELA(2), SYT1(1), VIPR2(3)	9165212	76	36	75	24	37	15	12	0	12	0	0.72	0.83
538	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(2), CDC25A(2), CDC25B(5), CDC25C(4), CDK7(1), MNAT1(1), XPO1(2)	2934044	19	14	19	9	6	8	3	1	1	0	0.73	0.84
539	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(6), ALAS2(6), CPO(3), FECH(3), GATA1(5), HBB(3), HMBS(2), UROD(1), UROS(1)	2771624	31	17	30	6	16	12	2	0	1	0	0.73	0.84
540	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(2), IL13RA2(3), IL4R(1), JAK1(4), JAK2(9), TYK2(1)	3524168	21	16	20	9	8	4	5	0	2	2	0.74	0.84
541	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(2), IL13RA2(3), IL4R(1), JAK1(4), JAK2(9), TYK2(1)	3524168	21	16	20	9	8	4	5	0	2	2	0.74	0.84
542	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(2), ACP2(2), ACP5(1), ACPP(4), ENPP1(4), ENPP3(4), FLAD1(1), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(4), PHPT1(1), TYR(3)	5070056	35	22	34	19	14	9	8	0	3	1	0.74	0.84
543	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(8), CD2(3), CD33(2), CD5(4), CD7(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(2), IL12A(1), IL12B(2), IL13(1), IL3(3), IL4(3), ITGAX(6), TLR2(6), TLR4(10), TLR7(7), TLR9(7)	6257856	69	28	68	22	25	22	19	0	3	0	0.74	0.84
544	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(10), CLOCK(8), CRY1(5), CRY2(1), PER1(1)	2894204	25	14	24	5	8	7	5	0	4	1	0.74	0.84
545	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(3), B4GALT1(6), B4GALT2(3), B4GALT3(7), B4GALT5(2), DDOST(2), DPAGT1(2), DPM1(1), FUT8(2), MAN1A1(5), MAN1B1(2), MGAT1(2), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), RPN2(1), ST6GAL1(1)	6566708	48	31	48	17	20	14	10	0	4	0	0.75	0.84
546	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(3), CAMK1G(5), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), ESRRA(3), HDAC5(2), MEF2A(4), MEF2C(9), MEF2D(1), PPARA(1), PPP3CA(3), PPP3CB(5), PPP3CC(4), SLC2A4(4), SYT1(1), YWHAH(1)	7001120	57	27	56	28	23	13	12	1	8	0	0.75	0.85
547	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(2), FUT1(4), FUT2(1), FUT3(4), FUT6(1), ST3GAL3(4)	1627768	16	12	16	5	10	4	2	0	0	0	0.75	0.85
548	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(3), CD3D(1), CD3G(2), CD4(2), IFNG(1), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), JAK2(9), STAT4(3), TYK2(1)	4905964	34	18	35	19	5	17	6	0	4	2	0.76	0.85
549	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(2), ACP2(2), ACP5(1), ACPP(4), ALPI(2), ALPL(1), ALPP(1), ALPPL2(1), CYP3A4(1), CYP3A43(2), CYP3A5(3), CYP3A7(6), DHRS1(1), DHRS2(3), DHRS3(2), PON1(6), PON2(2), PON3(2)	5862196	42	24	41	17	16	12	8	0	4	2	0.76	0.85
550	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(7), CREBBP(25), CTBP1(1), CTBP2(2), DLL1(4), DLL3(3), DLL4(2), DTX1(4), DTX2(4), DTX3(1), DTX3L(3), DTX4(3), DVL2(9), DVL3(4), EP300(15), HDAC1(2), HDAC2(2), HES1(1), JAG1(8), MAML1(3), MAML2(3), MAML3(1), NCOR2(2), NCSTN(5), NOTCH2(13), NOTCH3(15), NOTCH4(7), NUMB(2), NUMBL(3), PSEN1(3), PSEN2(2), PTCRA(2), RBPJ(5), RBPJL(3), SNW1(5)	22901968	174	60	171	66	62	53	31	1	27	0	0.76	0.85
551	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(2), EHHADH(2), HADHA(3), SDS(2)	1647524	9	7	9	3	3	2	0	0	4	0	0.76	0.85
552	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(7), ADSS(2), DHFR(1), HPRT1(2), IMPDH1(2), POLB(3), POLD1(5), POLG(5), PRPS2(2), RRM1(2)	4338448	31	23	31	12	15	12	2	0	2	0	0.78	0.87
553	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(3), IDI1(1), SQLE(2)	1124384	6	5	6	3	1	2	2	0	1	0	0.79	0.88
554	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(3), ARSE(2), ASAH1(3), B4GALT6(5), CERK(1), DEGS1(2), ENPP7(2), GAL3ST1(2), GALC(1), GLA(4), GLB1(3), LCT(20), NEU1(1), NEU2(1), NEU3(1), PPAP2B(1), SGMS1(3), SGMS2(6), SGPP1(2), SGPP2(4), SMPD1(6), SMPD3(3), SMPD4(1), SPHK1(1), SPHK2(1), SPTLC1(4), SPTLC2(2), UGCG(2), UGT8(8)	11820736	96	42	94	34	35	26	25	2	7	1	0.79	0.88
555	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(2), CAPNS1(1), CAPNS2(1), CDK5R1(1), CSNK1A1(2), CSNK1D(4), GSK3B(8), MAPT(5), PPP2CA(1)	3193856	26	16	26	8	12	5	5	1	3	0	0.79	0.88
556	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(5), HSD17B2(2), HSD17B3(2), HSD17B4(3), HSD3B1(3), HSD3B2(1)	2715720	18	12	18	4	5	7	4	0	2	0	0.80	0.88
557	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(4), UBE2A(2), UBE2B(2), UBE2C(2), UBE2D1(1), UBE2D3(1), UBE2E1(3), UBE2G1(2), UBE2I(2), UBE2J2(1), UBE2L3(2), UBE3A(11)	3526084	33	15	33	10	9	11	8	0	5	0	0.80	0.88
558	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(1), AGMAT(4), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH4A1(3), ALDH9A1(1), AMD1(1), AOC2(4), AOC3(4), ARG1(1), ARG2(5), ASL(2), CKM(5), CKMT1B(1), CKMT2(5), CPS1(14), DAO(6), GAMT(1), GATM(1), GLUD1(2), GOT1(6), GOT2(1), MAOA(3), MAOB(1), NOS1(11), NOS3(2), OAT(1), ODC1(5), OTC(5), P4HA1(1), P4HA2(2), P4HA3(2), P4HB(2), RARS(4), SMS(2)	14740640	141	46	139	48	54	47	21	1	18	0	0.80	0.88
559	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB27A(2), RAB3A(2), RAB4A(1), RAB6A(2), RAB9A(1)	1457536	13	9	13	2	4	6	2	0	1	0	0.80	0.88
560	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(8), ARHGDIB(3), BAG4(2), BCL2(1), BID(1), BIRC2(4), BIRC3(7), CASP2(4), CASP3(2), CASP6(2), CASP7(1), CASP8(11), CASP9(2), CFLAR(3), CHUK(6), CRADD(2), DAXX(1), DFFA(3), DFFB(2), LMNB1(4), LMNB2(1), MAP3K1(8), MAP3K14(3), MAP3K5(6), MAPK8(7), MDM2(4), NFKB1(6), NUMA1(10), PAK2(3), PRKCD(3), PRKDC(18), PSEN1(3), PSEN2(2), PTK2(5), RASA1(9), RB1(7), RELA(2), RIPK1(2), SPTAN1(13), TNFRSF1A(1), TRADD(1), TRAF1(2), TRAF2(1)	23656768	186	54	184	54	58	52	48	1	25	2	0.81	0.88
561	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(2)	1486144	8	6	8	5	1	3	2	0	2	0	0.81	0.88
562	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(4), FOS(1), GRB2(3), JAK2(9), MAP2K1(4), MAPK3(3), MAPK8(7), PLCG1(4), PTPN6(4), RAF1(6), SHC1(3), SOS1(7), STAT5B(3)	7317592	58	27	56	13	20	18	12	1	5	2	0.81	0.88
563	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(3), POLD1(5), POLD2(1), POLE(21), POLG(5), POLL(1), POLQ(12)	5719952	48	24	45	14	17	19	6	0	6	0	0.81	0.89
564	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(5), ALDOC(3), DERA(2), FBP2(3), G6PD(3), GPI(2), H6PD(4), PFKL(1), PFKM(4), PFKP(2), PGD(1), PGM1(4), PGM3(5), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(2), RPIA(3), TALDO1(3), TKT(3), TKTL1(5), TKTL2(7)	8185100	67	38	67	21	27	29	8	0	3	0	0.81	0.89
565	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(6), NR3C1(4), PPARG(1), RXRA(1)	1886864	13	9	13	10	1	6	3	0	3	0	0.82	0.89
566	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22(2), IL22RA1(1), JAK1(4), JAK2(9), JAK3(8), STAT1(6), STAT3(2), STAT5B(3), TYK2(1)	6252292	38	24	37	17	12	12	7	0	5	2	0.82	0.89
567	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(3), CD34(1), CD3D(1), CD3G(2), CD4(2), CD58(2), IL3(3), IL6(2), IL8(1), KITLG(2)	2136968	19	11	18	8	6	9	3	0	1	0	0.82	0.89
568	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(4), AASDHPPT(3), AASS(9), ACAT1(1), ACAT2(2), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), BBOX1(3), DLST(1), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(2), EHMT2(3), GCDH(5), HADHA(3), PLOD1(4), PLOD2(5), PLOD3(4), SDS(2), SHMT1(2), SHMT2(2), TMLHE(3)	12250168	99	40	97	25	36	28	18	2	15	0	0.82	0.89
569	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), ANKRD1(6), ATF3(1), CYR61(2), HBEGF(1), IFNG(1), IFRD1(5), IL1A(1), IL1R1(4), MYOG(1), NR4A3(4), WDR1(3)	3716372	30	16	30	6	9	11	7	0	3	0	0.82	0.89
570	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(8), GNA12(2), PRKACB(1), PRKACG(3), PRKAG1(1), PRKAR2B(3)	3412280	18	14	18	12	6	6	0	0	6	0	0.83	0.89
571	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(1), ALPP(1), ALPPL2(1), ASCC3(19), ATP13A2(3), DDX18(3), DDX19A(3), DDX23(4), DDX4(3), DDX41(2), DDX47(3), DDX50(3), DDX52(2), DDX54(5), DDX55(3), DDX56(5), DHFR(1), DHX58(3), ENTPD7(4), EP400(20), ERCC2(4), ERCC3(7), GGH(1), IFIH1(5), MOV10L1(13), RAD54B(8), RAD54L(3), RUVBL2(1), SETX(20), SKIV2L2(3), SMARCA2(10), SMARCA5(7)	21329036	173	52	170	42	66	47	36	0	23	1	0.83	0.89
572	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(2), CASP7(1), DFFA(3), DFFB(2), GZMB(2), HMGB1(1), HMGB2(1), TOP2A(5), TOP2B(9)	3488500	26	14	25	6	4	12	7	0	3	0	0.83	0.89
573	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), G6PD(3), GPI(2), H6PD(4), PFKM(4), PFKP(2), PGD(1), PGM1(4), PGM3(5), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(2), RPIA(3), TALDO1(3), TKT(3)	6863396	52	34	52	17	21	25	5	0	1	0	0.83	0.90
574	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(18), ACACB(15), FASN(1), MCAT(1), OLAH(1), OXSM(5)	5111576	41	22	40	11	16	13	8	0	4	0	0.83	0.90
575	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(5), ARSB(5), FUCA1(3), GALNS(4), GLB1(3), GNS(4), GUSB(2), HEXB(3), HGSNAT(6), HPSE(2), HPSE2(12), IDS(2), IDUA(1), LCT(20), MAN2B1(5), MAN2B2(1), MAN2C1(6), MANBA(7), NAGLU(4), NEU1(1), NEU2(1), NEU3(1), SPAM1(4)	11667372	102	38	100	35	37	28	24	1	12	0	0.84	0.90
576	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(5), ACTN2(8), ACTN3(3), CAPN1(2), CAPNS1(1), CAPNS2(1), ITGA1(3), ITGB1(6), ITGB3(9), PTK2(5), SPTAN1(13), SRC(3), TLN1(7)	9787700	70	38	70	31	34	22	10	0	3	1	0.84	0.90
577	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(6), KHK(1), LCT(20), MPI(1), PGM1(4), PYGL(2), PYGM(4), TPI1(1), TREH(2)	4563208	41	26	41	15	18	12	11	0	0	0	0.84	0.90
578	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(2), ACP2(2), ACP5(1), ACPP(4), ENPP1(4), ENPP3(4), FLAD1(1), TYR(3)	3277220	21	14	20	12	8	5	6	0	1	1	0.84	0.90
579	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(2), PAPSS2(4), SULT1A2(1), SULT1E1(2), SULT2A1(2), SUOX(2)	2042004	14	8	14	1	5	5	1	0	3	0	0.84	0.90
580	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(8), CD38(2), ENPP1(4), ENPP3(4), NADSYN1(2), NMNAT1(2), NMNAT2(2), NNMT(3), NNT(3), NT5E(3), NT5M(1), QPRT(1)	4937944	35	19	35	17	11	13	6	0	5	0	0.86	0.91
581	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(2), CAPN2(6), CAPNS1(1), CAPNS2(1), EGF(3), EGFR(11), ITGA1(3), ITGB1(6), MAPK1(2), MAPK3(3), MYL2(1), MYLK(14), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PTK2(5), TLN1(7)	11184912	82	40	82	25	34	24	18	0	6	0	0.86	0.91
582	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(3), ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), FPGT(5), GCK(2), GMDS(1), GMPPA(7), HK1(6), HK2(3), HK3(5), KHK(1), MPI(1), PFKFB1(7), PFKFB4(2), PFKM(4), PFKP(2), PMM1(3), SORD(2), TPI1(1)	8156180	67	37	67	25	25	32	7	0	3	0	0.87	0.92
583	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(6), DUSP1(2), IKBKAP(2), IKBKB(4), MAP3K1(8), MAP3K14(3), NFKB1(6), RELA(2), RIPK1(2), TANK(6), TNFAIP3(3), TRAF1(2), TRAF2(1), TRAF3(6)	7611944	53	26	52	18	25	13	9	1	5	0	0.89	0.94
584	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(4), SEC61A2(1), SRP19(1), SRP54(3), SRP68(4), SRP72(4), SRPR(1)	2528892	18	12	18	5	6	8	2	1	1	0	0.89	0.94
585	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(3), CAMK1G(5), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), CAMKK1(1), CAMKK2(1), CREB1(1), SYT1(1)	3947040	23	15	23	14	7	8	6	0	2	0	0.90	0.94
586	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(5), ALDOC(3), DLAT(3), DLD(1), ENO2(3), ENO3(4), FBP2(3), G6PC(4), GCK(2), GOT1(6), GOT2(1), GPI(2), HK1(6), HK2(3), HK3(5), LDHA(2), LDHAL6B(2), LDHB(3), LDHC(2), MDH1(1), MDH2(1), PC(6), PCK1(3), PDHA1(5), PDHA2(8), PDHB(2), PDHX(2), PFKL(1), PFKM(4), PFKP(2), PGAM1(3), PGAM2(1), PGK1(3), PGK2(7), PKM2(2), TNFAIP1(3), TPI1(1)	14078660	116	44	113	47	47	42	16	0	11	0	0.90	0.94
587	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(3), CHST12(3), CHST13(2), PAPSS1(2), PAPSS2(4), SULT1A1(2), SULT1A2(1), SULT1E1(2), SULT2A1(2), SULT2B1(1), SUOX(2)	3092160	25	14	25	5	10	8	4	0	3	0	0.90	0.95
588	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(5), MBTPS1(8), SCAP(2), SREBF1(1), SREBF2(2)	3992908	19	14	19	12	7	6	3	0	3	0	0.91	0.96
589	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(3), DDX20(4), E2F4(1), ETS1(1), ETS2(3), ETV3(1), FOS(1), HDAC2(2), HDAC5(2), NCOR2(2), RBL1(5), RBL2(8), SIN3A(10), SIN3B(4)	8946576	49	25	48	27	17	15	9	0	8	0	0.92	0.96
590	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(8), CYB5R3(1), GCK(2), GFPT1(4), GNE(2), GNPDA2(1), HEXB(3), HK1(6), HK2(3), HK3(5), PGM3(5), RENBP(1)	5735140	41	25	40	13	13	19	8	0	1	0	0.92	0.96
591	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(5), FUCA1(3), GLB1(3), HEXB(3), LCT(20), MAN2B1(5), MAN2B2(1), MAN2C1(6), MANBA(7), NEU1(1), NEU2(1), NEU3(1)	6812068	56	29	56	21	21	16	15	0	4	0	0.92	0.96
592	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPL13(1), RPL10A(2), RPL10L(2), RPL11(1), RPL18A(1), RPL19(1), RPL21(1), RPL22L1(1), RPL24(1), RPL28(2), RPL3(2), RPL31(2), RPL32(1), RPL35(1), RPL39(1), RPL3L(1), RPL6(3), RPL7(1), RPL9(4), RPS11(1), RPS13(1), RPS15A(1), RPS16(2), RPS18(2), RPS2(1), RPS20(1), RPS23(4), RPS3(2), RPS9(2), RPSA(1)	7558400	48	28	47	14	14	13	16	1	4	0	0.93	0.96
593	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGAP3(3), ARFGEF2(8), CLTA(2), COPA(2), GBF1(12), GPLD1(6), KDELR1(2), KDELR2(1), KDELR3(1)	5467848	38	22	37	15	16	9	8	1	4	0	0.94	0.97
594	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), B4GALT1(6), B4GALT2(3), G6PC(4), G6PC2(1), GALE(1), GALK2(3), GALT(2), GANC(3), GCK(2), GLA(4), GLB1(3), HK1(6), HK2(3), HK3(5), HSD3B7(2), LALBA(1), LCT(20), MGAM(13), PFKL(1), PFKM(4), PFKP(2), PGM1(4), PGM3(5), RDH11(1), RDH12(3), RDH13(1), UGP2(7)	13025704	113	43	113	38	50	39	20	0	4	0	0.94	0.97
595	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(5), ARSD(3), ARSE(2), ASAH1(3), GAL3ST1(2), GALC(1), GLA(4), GLB1(3), LCT(20), NEU1(1), NEU2(1), NEU3(1), PPAP2B(1), SMPD1(6), SPTLC1(4), SPTLC2(2), UGCG(2)	8022488	62	30	62	23	24	18	14	2	4	0	0.94	0.98
596	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(2), HS3ST2(3), HS3ST3B1(2), XYLT1(6), XYLT2(2)	2235840	16	11	15	13	7	4	2	1	2	0	0.95	0.98
597	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(2), HS3ST2(3), HS3ST3B1(2), XYLT1(6), XYLT2(2)	2235840	16	11	15	13	7	4	2	1	2	0	0.95	0.98
598	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(5), NR1H3(4), NR1H4(2), RXRA(1)	1809836	13	10	13	7	6	3	3	1	0	0	0.96	0.99
599	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(3), HMGCR(3), IDI1(1), LSS(2), MVK(1), NQO1(1), NQO2(1), PMVK(1), SC5DL(3), SQLE(2)	3786500	20	16	20	8	10	5	4	0	1	0	0.96	0.99
600	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(1), FOS(1), KEAP1(3), MAPK1(2), MAPK14(3), MAPK8(7), NFE2L2(4), PRKCA(4)	2938936	25	13	25	3	6	10	7	1	1	0	0.97	0.99
601	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), ACAT2(2), BDH1(1), HMGCL(1), HMGCS1(1), HMGCS2(1), OXCT1(3), OXCT2(1)	2448320	11	10	11	5	6	4	1	0	0	0	0.97	0.99
602	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(3), DHCR24(2), DHCR7(2), EBP(2), FDFT1(3), GGCX(5), GGPS1(1), HMGCR(3), IDI1(1), IDI2(1), LSS(2), MVK(1), NQO1(1), NSDHL(2), PMVK(1), SC4MOL(1), SC5DL(3), SQLE(2)	6569804	39	23	39	14	15	14	6	0	4	0	0.97	0.99
603	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(3), EGFR(11), MAP2K1(4), MAP3K1(8), MAPK14(3), NCOR2(2), RXRA(1), THRA(2), THRB(4)	5849792	38	22	38	15	18	10	8	0	2	0	0.97	0.99
604	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(6), IFNG(1), IKBKB(4), IL2(4), IL4(3), MAP3K1(8), MAP3K5(6), MAP4K5(2), MAPK14(3), MAPK8(7), NFKB1(6), RELA(2), TNFRSF9(3), TRAF2(1)	6686712	57	23	57	15	21	23	10	1	2	0	0.98	1.00
605	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(2), FDFT1(3), HMGCR(3), HMGCS1(1), IDI1(1), LSS(2), MVK(1), NSDHL(2), PMVK(1), SC4MOL(1), SC5DL(3), SQLE(2)	4506660	25	16	25	10	11	7	5	0	2	0	0.98	1.00
606	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(8), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLRMT(1)	4496660	28	16	28	4	10	9	7	1	1	0	0.98	1.00
607	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(6), IKBKB(4), IL1A(1), IL1R1(4), IRAK1(1), MAP3K1(8), MAP3K14(3), MAP3K7(4), MYD88(2), NFKB1(6), RELA(2), RIPK1(2), TLR4(10), TNFAIP3(3), TNFRSF1A(1), TRADD(1), TRAF6(4)	8211660	62	25	62	18	23	19	14	0	6	0	0.98	1.00
608	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(7), GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(5), HDAC3(2), NCOA1(8), NCOA2(7), NCOA3(11), NCOR2(2), POLR2A(6), RXRA(1), TBP(1)	8507856	58	30	58	21	19	22	13	1	3	0	0.99	1.00
609	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(1), GLUD1(2), OAT(1)	1833156	7	6	7	3	4	1	2	0	0	0	0.99	1.00
610	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(3), ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), FPGT(5), FUK(1), GMDS(1), GMPPA(7), HK1(6), HK2(3), HK3(5), HSD3B7(2), KHK(1), LHPP(2), MPI(1), MTMR1(5), MTMR2(2), MTMR6(4), PFKFB1(7), PFKFB4(2), PFKL(1), PFKM(4), PFKP(2), PHPT1(1), PMM1(3), RDH11(1), RDH12(3), RDH13(1), SORD(2), TPI1(1), TSTA3(1)	12661132	89	40	89	39	36	39	9	0	5	0	0.99	1.00
611	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1), HSD3B7(2), RDH11(1), RDH12(3), RDH13(1)	1627788	8	6	8	4	4	4	0	0	0	0	0.99	1.00
612	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(3), GPLD1(6), PGAP1(8), PIGA(1), PIGB(2), PIGG(3), PIGK(4), PIGM(3), PIGN(2), PIGO(3), PIGQ(1), PIGS(2), PIGT(3), PIGU(1), PIGV(2), PIGW(1), PIGX(4)	8312940	49	22	48	19	15	16	12	0	6	0	1.00	1.00
613	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), IL1B(1), MST1(1), MST1R(1)	2077248	5	5	5	4	3	2	0	0	0	0	1.00	1.00
614	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GAT1(1), B3GAT3(1), CHPF(3), CHST11(3), CHST12(3), CHST13(2), CHST14(1), CHSY1(5), DSE(3), UST(1), XYLT1(6), XYLT2(2)	4799936	31	18	31	24	11	12	6	0	2	0	1.00	1.00
615	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(1), ALPP(1), ALPPL2(1), DHFR(1), GGH(1)	2173660	7	7	7	1	2	4	1	0	0	0	1.00	1.00
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		169792	0	0	0	1	0	0	0	0	0	0	1.00	1.00