E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.008 0.071 -9999.0 0.0 -0.296 21.0 21.0 KLHL20 0.049 0.094 0.234 42.0 -0.192 16.0 58.0 CYFIP2 0.031 0.013 -9999.0 0.0 0.0 76.0 76.0 Rac1/GDP 0.008 0.061 0.193 3.0 -0.25 14.0 17.0 ENAH 0.007 0.074 -9999.0 0.0 -0.317 20.0 20.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.0 0.0 0.0 29.0 -0.0 5.0 34.0 RAP1A 0.036 0.005 -9999.0 0.0 0.0 10.0 10.0 CTNNB1 0.036 0.006 -9999.0 0.0 0.0 15.0 15.0 CDC42/GTP -0.023 0.057 0.121 25.0 -0.205 21.0 46.0 ABI1/Sra1/Nap1 -0.015 0.034 -9999.0 0.0 -0.133 29.0 29.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.084 0.039 -9999.0 0.0 -0.131 8.0 8.0 RAPGEF1 -0.0 0.078 0.214 1.0 -0.281 19.0 20.0 CTNND1 0.035 0.009 -9999.0 0.0 0.0 31.0 31.0 regulation of calcium-dependent cell-cell adhesion 0.021 0.075 -9999.0 0.0 -0.296 22.0 22.0 CRK 0.007 0.08 0.194 3.0 -0.293 20.0 23.0 E-cadherin/gamma catenin/alpha catenin 0.062 0.035 -9999.0 0.0 -0.126 8.0 8.0 alphaE/beta7 Integrin 0.049 0.026 -9999.0 0.0 -0.145 7.0 7.0 IQGAP1 0.033 0.011 -9999.0 0.0 0.0 48.0 48.0 NCKAP1 0.037 0.002 -9999.0 0.0 0.0 2.0 2.0 Rap1/GTP/I-afadin 0.043 0.015 -9999.0 0.0 -0.103 1.0 1.0 DLG1 0.008 0.075 -9999.0 0.0 -0.3 22.0 22.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.034 0.044 -9999.0 0.0 -0.18 29.0 29.0 MLLT4 0.034 0.009 -9999.0 0.0 0.0 34.0 34.0 ARF6/GTP/NME1/Tiam1 0.036 0.033 -9999.0 0.0 -0.103 23.0 23.0 PI3K -0.041 0.058 0.06 1.0 -0.232 29.0 30.0 ARF6 0.035 0.009 -9999.0 0.0 0.0 29.0 29.0 mol:Ca2+ 0.0 0.0 0.001 68.0 -0.0 27.0 95.0 E-cadherin/gamma catenin 0.048 0.018 -9999.0 0.0 -9999.0 0.0 0.0 TIAM1 0.034 0.011 -9999.0 0.0 0.0 46.0 46.0 E-cadherin(dimer)/Ca2+ 0.072 0.054 -9999.0 0.0 -0.141 25.0 25.0 AKT1 -0.02 0.056 0.135 9.0 -0.181 24.0 33.0 PIK3R1 0.032 0.012 -9999.0 0.0 0.0 63.0 63.0 CDH1 0.034 0.01 -9999.0 0.0 0.0 37.0 37.0 RhoA/GDP 0.017 0.074 0.204 4.0 -0.246 16.0 20.0 actin cytoskeleton organization 0.041 0.076 0.171 71.0 -0.143 15.0 86.0 CDC42/GDP 0.016 0.072 0.204 4.0 -0.246 14.0 18.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.049 -9999.0 0.0 -0.197 23.0 23.0 ITGB7 0.036 0.006 -9999.0 0.0 0.0 14.0 14.0 RAC1 0.025 0.017 -9999.0 0.0 0.0 162.0 162.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.077 0.058 -9999.0 0.0 -0.151 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.056 0.031 -9999.0 0.0 -0.113 10.0 10.0 mol:GDP -0.0 0.076 0.196 5.0 -0.283 14.0 19.0 CDC42/GTP/IQGAP1 0.035 0.042 -9999.0 0.0 -0.117 33.0 33.0 JUP 0.033 0.011 -9999.0 0.0 0.0 51.0 51.0 p120 catenin/RhoA/GDP 0.031 0.082 0.215 5.0 -0.247 18.0 23.0 RAC1/GTP/IQGAP1 0.024 0.043 -9999.0 0.0 -0.12 30.0 30.0 PIP5K1C/AP1M1 0.02 0.03 -9999.0 0.0 -0.134 18.0 18.0 RHOA 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 CDC42 0.035 0.008 -9999.0 0.0 0.0 26.0 26.0 CTNNA1 0.036 0.007 -9999.0 0.0 0.0 18.0 18.0 positive regulation of S phase of mitotic cell cycle 0.015 0.048 0.122 17.0 -0.125 29.0 46.0 NME1 -0.0 0.0 -9999.0 0.0 -0.0 31.0 31.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.009 0.073 -9999.0 0.0 -0.305 20.0 20.0 regulation of cell-cell adhesion -0.027 0.04 -9999.0 0.0 -0.172 25.0 25.0 WASF2 -0.008 0.018 -9999.0 0.0 -0.073 29.0 29.0 Rap1/GTP -0.019 0.067 0.15 32.0 -0.223 22.0 54.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.091 0.051 -9999.0 0.0 -0.132 12.0 12.0 CCND1 0.017 0.057 0.139 17.0 -0.152 29.0 46.0 VAV2 0.023 0.109 -9999.0 0.0 -0.523 10.0 10.0 RAP1/GDP -0.006 0.069 0.16 29.0 -0.254 15.0 44.0 adherens junction assembly 0.009 0.071 -9999.0 0.0 -0.296 20.0 20.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.017 -9999.0 0.0 0.0 156.0 156.0 PIP5K1C 0.033 0.011 -9999.0 0.0 0.0 47.0 47.0 regulation of heterotypic cell-cell adhesion 0.069 0.047 0.201 3.0 -0.138 13.0 16.0 E-cadherin/beta catenin 0.007 0.02 -9999.0 0.0 -0.094 7.0 7.0 mol:GTP 0.0 0.0 0.001 62.0 -0.0 31.0 93.0 SRC 0.007 0.07 -9999.0 0.0 -0.291 21.0 21.0 PIK3CA 0.031 0.014 -9999.0 0.0 0.0 82.0 82.0 Rac1/GTP -0.008 0.07 0.187 1.0 -0.29 18.0 19.0 E-cadherin/beta catenin/alpha catenin 0.064 0.036 -9999.0 0.0 -0.136 10.0 10.0 ITGAE 0.035 0.007 -9999.0 0.0 0.0 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.021 0.077 -9999.0 0.0 -0.301 22.0 22.0