Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.008 0.059 -9999.0 0.0 -0.22 25.0 25.0 epithelial cell differentiation 0.064 0.052 -9999.0 0.0 -0.139 25.0 25.0 CYFIP2 0.031 0.013 -9999.0 0.0 0.0 76.0 76.0 ENAH -0.042 0.072 0.315 7.0 -0.274 7.0 14.0 EGFR 0.009 0.016 -9999.0 0.0 0.0 380.0 380.0 EPHA2 0.033 0.011 -9999.0 0.0 0.0 55.0 55.0 MYO6 -0.029 0.05 0.184 9.0 -0.218 13.0 22.0 CTNNB1 0.036 0.006 -9999.0 0.0 0.0 15.0 15.0 ABI1/Sra1/Nap1 0.029 0.065 -9999.0 0.0 -0.127 56.0 56.0 AQP5 -0.021 0.053 0.204 2.0 -0.288 10.0 12.0 CTNND1 0.035 0.009 -9999.0 0.0 0.0 31.0 31.0 mol:PI-4-5-P2 -0.031 0.045 0.174 7.0 -0.209 13.0 20.0 regulation of calcium-dependent cell-cell adhesion -0.028 0.044 0.184 8.0 -0.194 8.0 16.0 EGF 0.035 0.008 -9999.0 0.0 0.0 25.0 25.0 NCKAP1 0.037 0.002 -9999.0 0.0 0.0 2.0 2.0 AQP3 -0.035 0.076 -9999.0 0.0 -0.298 32.0 32.0 cortical microtubule organization 0.064 0.052 -9999.0 0.0 -0.139 25.0 25.0 GO:0000145 -0.03 0.041 0.157 7.0 -0.2 13.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.071 0.054 -9999.0 0.0 -0.14 25.0 25.0 MLLT4 0.034 0.009 -9999.0 0.0 0.0 34.0 34.0 ARF6/GDP -0.053 0.04 -9999.0 0.0 -0.222 13.0 13.0 ARF6 0.035 0.009 -9999.0 0.0 0.0 29.0 29.0 Ephrin A1/EPHA2/NCK1/GIT1 0.075 0.055 -9999.0 0.0 -0.13 25.0 25.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.031 0.087 0.16 1.0 -0.294 38.0 39.0 PVRL2 0.034 0.009 -9999.0 0.0 0.0 35.0 35.0 ZYX -0.022 0.045 0.177 6.0 -0.214 15.0 21.0 ARF6/GTP 0.079 0.061 -9999.0 0.0 -0.13 24.0 24.0 CDH1 0.034 0.01 -9999.0 0.0 0.0 37.0 37.0 EGFR/EGFR/EGF/EGF -0.001 0.06 -9999.0 0.0 -0.127 67.0 67.0 RhoA/GDP 0.064 0.057 -9999.0 0.0 -0.143 29.0 29.0 actin cytoskeleton organization -0.024 0.047 0.166 7.0 -0.229 12.0 19.0 IGF-1R heterotetramer 0.033 0.011 -9999.0 0.0 0.0 54.0 54.0 GIT1 0.037 0.003 -9999.0 0.0 0.0 3.0 3.0 IGF1R 0.033 0.011 -9999.0 0.0 0.0 54.0 54.0 IGF1 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 DIAPH1 -0.13 0.275 -9999.0 0.0 -0.582 50.0 50.0 Wnt receptor signaling pathway -0.064 0.052 0.139 25.0 -9999.0 0.0 25.0 RHOA 0.035 0.007 -9999.0 0.0 0.0 21.0 21.0 RhoA/GTP -0.054 0.042 -9999.0 0.0 -0.23 14.0 14.0 CTNNA1 0.035 0.007 -9999.0 0.0 0.0 18.0 18.0 VCL -0.024 0.048 0.167 7.0 -0.234 12.0 19.0 EFNA1 0.033 0.011 -9999.0 0.0 0.0 52.0 52.0 LPP -0.03 0.047 0.183 4.0 -0.238 13.0 17.0 Ephrin A1/EPHA2 0.046 0.063 -9999.0 0.0 -0.141 41.0 41.0 SEC6/SEC8 -0.044 0.029 -9999.0 0.0 -0.145 26.0 26.0 MGAT3 -0.028 0.045 0.185 8.0 -0.197 8.0 16.0 HGF/MET 0.037 0.048 -9999.0 0.0 -0.139 15.0 15.0 HGF 0.024 0.018 -9999.0 0.0 0.0 177.0 177.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.01 0.058 -9999.0 0.0 -0.209 28.0 28.0 actin cable formation -0.04 0.103 0.31 10.0 -0.317 27.0 37.0 KIAA1543 -0.025 0.037 0.16 7.0 -0.183 8.0 15.0 KIFC3 -0.031 0.042 0.193 5.0 -0.198 8.0 13.0 NCK1 0.035 0.008 -9999.0 0.0 0.0 27.0 27.0 EXOC3 0.037 0.003 -9999.0 0.0 0.0 4.0 4.0 ACTN1 -0.027 0.051 0.187 7.0 -0.222 16.0 23.0 NCK1/GIT1 0.05 0.024 -9999.0 0.0 -0.145 6.0 6.0 mol:GDP 0.064 0.052 -9999.0 0.0 -0.139 25.0 25.0 EXOC4 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.028 0.031 0.053 22.0 -0.133 25.0 47.0 PIP5K1C -0.031 0.046 0.176 7.0 -0.212 13.0 20.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.017 -9999.0 0.0 0.0 156.0 156.0 ROCK1 -0.035 0.086 0.346 11.0 -0.297 5.0 16.0 adherens junction assembly -0.024 0.072 0.223 6.0 -0.283 21.0 27.0 IGF-1R heterotetramer/IGF1 0.05 0.062 -9999.0 0.0 -0.147 37.0 37.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.047 0.023 -9999.0 0.0 -0.145 3.0 3.0 MET 0.023 0.018 -9999.0 0.0 0.0 189.0 189.0 PLEKHA7 -0.028 0.031 0.053 22.0 -0.133 25.0 47.0 mol:GTP 0.072 0.053 -9999.0 0.0 -0.13 25.0 25.0 establishment of epithelial cell apical/basal polarity -0.039 0.039 0.121 12.0 -0.187 10.0 22.0 cortical actin cytoskeleton stabilization 0.008 0.059 -9999.0 0.0 -0.22 25.0 25.0 regulation of cell-cell adhesion -0.024 0.047 0.166 7.0 -0.229 12.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.01 0.058 -9999.0 0.0 -0.209 28.0 28.0