Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.139 0.194 -9999.0 0.0 -0.496 12.0 12.0 IHH -0.086 0.142 -9999.0 0.0 -0.314 17.0 17.0 SHH Np/Cholesterol/GAS1 0.025 0.049 -9999.0 0.0 -9999.0 0.0 0.0 LRPAP1 0.04 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.024 0.049 -9999.0 0.0 -9999.0 0.0 0.0 SMO/beta Arrestin2 -0.07 0.164 -9999.0 0.0 -0.411 7.0 7.0 SMO -0.089 0.158 -9999.0 0.0 -0.437 7.0 7.0 AKT1 -0.057 0.203 -9999.0 0.0 -0.665 6.0 6.0 ARRB2 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.023 0.087 -9999.0 0.0 -0.482 2.0 2.0 ADRBK1 0.041 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.088 0.156 -9999.0 0.0 -0.431 7.0 7.0 STIL -0.049 0.116 -9999.0 0.0 -0.358 1.0 1.0 DHH N/PTCH2 0.044 0.069 -9999.0 0.0 -0.346 2.0 2.0 DHH N/PTCH1 -0.084 0.122 -9999.0 0.0 -0.277 13.0 13.0 PIK3CA 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.026 0.087 -9999.0 0.0 -0.482 2.0 2.0 PTHLH -0.23 0.354 -9999.0 0.0 -0.947 12.0 12.0 determination of left/right symmetry -0.088 0.156 -9999.0 0.0 -0.431 7.0 7.0 PIK3R1 0.003 0.127 -9999.0 0.0 -0.449 5.0 5.0 skeletal system development -0.227 0.349 -9999.0 0.0 -0.934 12.0 12.0 IHH N/Hhip -0.064 0.142 -9999.0 0.0 -0.299 14.0 14.0 DHH N/Hhip 0.003 0.139 -9999.0 0.0 -0.291 11.0 11.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.088 0.156 -9999.0 0.0 -0.431 7.0 7.0 pancreas development -0.021 0.142 -9999.0 0.0 -0.343 11.0 11.0 HHAT 0.032 0.043 -9999.0 0.0 -0.313 1.0 1.0 PI3K 0.029 0.099 -9999.0 0.0 -0.32 5.0 5.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.025 0.072 -9999.0 0.0 -0.313 3.0 3.0 somite specification -0.088 0.156 -9999.0 0.0 -0.431 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.068 0.1 -9999.0 0.0 -0.256 9.0 9.0 SHH Np/Cholesterol/PTCH2 0.034 0.029 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin -0.01 0.11 -9999.0 0.0 -0.281 9.0 9.0 SHH 0.018 0.03 -9999.0 0.0 -0.213 1.0 1.0 catabolic process -0.101 0.121 -9999.0 0.0 -0.286 16.0 16.0 SMO/Vitamin D3 -0.074 0.135 -9999.0 0.0 -0.308 12.0 12.0 SHH Np/Cholesterol/Hhip 0.003 0.081 -9999.0 0.0 -0.265 2.0 2.0 LRP2 -0.051 0.196 -9999.0 0.0 -0.482 12.0 12.0 receptor-mediated endocytosis -0.093 0.174 -9999.0 0.0 -0.408 12.0 12.0 SHH Np/Cholesterol/BOC 0.025 0.058 -9999.0 0.0 -0.265 2.0 2.0 SHH Np/Cholesterol/CDO 0.011 0.087 -9999.0 0.0 -0.301 4.0 4.0 mesenchymal cell differentiation -0.003 0.081 0.264 2.0 -9999.0 0.0 2.0 mol:Vitamin D3 -0.052 0.122 -9999.0 0.0 -0.257 9.0 9.0 IHH N/PTCH2 -0.021 0.093 -9999.0 0.0 -0.2 5.0 5.0 CDON -0.017 0.161 -9999.0 0.0 -0.461 8.0 8.0 IHH N/PTCH1 -0.094 0.131 -9999.0 0.0 -0.288 16.0 16.0 Megalin/LRPAP1 -0.01 0.147 -9999.0 0.0 -0.346 11.0 11.0 PTCH2 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.02 0.024 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.101 0.122 -9999.0 0.0 -0.287 16.0 16.0 HHIP -0.021 0.142 -9999.0 0.0 -0.344 11.0 11.0