Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.019 0.09 -9999.0 0.0 -0.242 9.0 9.0 epithelial cell differentiation -0.001 0.109 -9999.0 0.0 -0.245 9.0 9.0 CYFIP2 0.025 0.063 -9999.0 0.0 -0.482 1.0 1.0 ENAH 0.005 0.147 0.306 3.0 -0.328 5.0 8.0 EGFR -0.025 0.156 -9999.0 0.0 -0.398 10.0 10.0 EPHA2 0.018 0.096 -9999.0 0.0 -0.426 3.0 3.0 MYO6 0.024 0.133 -9999.0 0.0 -0.27 7.0 7.0 CTNNB1 0.027 0.02 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.051 0.062 -9999.0 0.0 -0.293 1.0 1.0 AQP5 0.011 0.112 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.011 0.121 -9999.0 0.0 -0.482 4.0 4.0 mol:PI-4-5-P2 0.025 0.125 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.033 0.171 -9999.0 0.0 -0.353 9.0 9.0 EGF -0.129 0.205 -9999.0 0.0 -0.366 29.0 29.0 NCKAP1 0.029 0.059 -9999.0 0.0 -0.313 2.0 2.0 AQP3 -0.031 0.183 -9999.0 0.0 -0.523 6.0 6.0 cortical microtubule organization -0.001 0.109 -9999.0 0.0 -0.245 9.0 9.0 GO:0000145 0.013 0.118 0.191 9.0 -9999.0 0.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.003 0.113 -9999.0 0.0 -0.247 9.0 9.0 MLLT4 0.03 0.063 -9999.0 0.0 -0.482 1.0 1.0 ARF6/GDP -0.058 0.129 -9999.0 0.0 -0.433 5.0 5.0 ARF6 0.035 0.014 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.034 0.15 -9999.0 0.0 -0.371 7.0 7.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.005 0.121 -9999.0 0.0 -0.354 1.0 1.0 PVRL2 0.041 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.017 0.12 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.039 0.145 -9999.0 0.0 -0.486 3.0 3.0 CDH1 -0.031 0.165 -9999.0 0.0 -0.405 11.0 11.0 EGFR/EGFR/EGF/EGF -0.094 0.144 -9999.0 0.0 -0.362 8.0 8.0 RhoA/GDP 0.003 0.106 -9999.0 0.0 -0.235 8.0 8.0 actin cytoskeleton organization 0.017 0.125 0.205 1.0 -0.445 1.0 2.0 IGF-1R heterotetramer 0.034 0.062 -9999.0 0.0 -0.482 1.0 1.0 GIT1 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.034 0.062 -9999.0 0.0 -0.482 1.0 1.0 IGF1 -0.023 0.148 -9999.0 0.0 -0.359 11.0 11.0 DIAPH1 0.022 0.171 -9999.0 0.0 -0.641 3.0 3.0 Wnt receptor signaling pathway 0.001 0.109 0.245 9.0 -9999.0 0.0 9.0 RHOA 0.028 0.019 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.059 0.129 -9999.0 0.0 -0.431 5.0 5.0 CTNNA1 0.033 0.016 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.016 0.127 0.207 1.0 -0.457 1.0 2.0 EFNA1 -0.023 0.165 -9999.0 0.0 -0.482 8.0 8.0 LPP -0.01 0.138 -9999.0 0.0 -0.357 3.0 3.0 Ephrin A1/EPHA2 -0.039 0.148 -9999.0 0.0 -0.399 6.0 6.0 SEC6/SEC8 -0.023 0.086 -9999.0 0.0 -0.411 1.0 1.0 MGAT3 -0.034 0.173 -9999.0 0.0 -0.359 9.0 9.0 HGF/MET -0.016 0.105 -9999.0 0.0 -0.269 1.0 1.0 HGF 0.015 0.094 -9999.0 0.0 -0.356 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.019 0.091 -9999.0 0.0 -0.243 9.0 9.0 actin cable formation 0.046 0.167 0.273 14.0 -0.354 3.0 17.0 KIAA1543 0.012 0.122 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.02 0.125 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.031 0.063 -9999.0 0.0 -0.482 1.0 1.0 EXOC3 0.034 0.062 -9999.0 0.0 -0.482 1.0 1.0 ACTN1 -0.001 0.144 -9999.0 0.0 -0.374 3.0 3.0 NCK1/GIT1 0.049 0.057 -9999.0 0.0 -0.407 1.0 1.0 mol:GDP -0.001 0.109 -9999.0 0.0 -0.245 9.0 9.0 EXOC4 0.038 0.012 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.035 0.082 -9999.0 0.0 -0.234 9.0 9.0 PIP5K1C 0.025 0.127 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.039 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.02 0.172 0.323 4.0 -0.401 4.0 8.0 adherens junction assembly 0.036 0.13 0.323 2.0 -9999.0 0.0 2.0 IGF-1R heterotetramer/IGF1 -0.026 0.131 -9999.0 0.0 -0.36 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.05 0.051 -9999.0 0.0 -0.346 1.0 1.0 MET 0.024 0.075 -9999.0 0.0 -0.398 2.0 2.0 PLEKHA7 0.022 0.125 -9999.0 0.0 -0.237 8.0 8.0 mol:GTP 0.032 0.148 -9999.0 0.0 -0.369 7.0 7.0 establishment of epithelial cell apical/basal polarity -0.029 0.082 -9999.0 0.0 -0.395 1.0 1.0 cortical actin cytoskeleton stabilization -0.019 0.09 -9999.0 0.0 -0.242 9.0 9.0 regulation of cell-cell adhesion 0.017 0.125 0.205 1.0 -0.445 1.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.019 0.091 -9999.0 0.0 -0.243 9.0 9.0