Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.024 0.08 -9999.0 0.0 -0.191 3.0 3.0 epithelial cell differentiation 0.012 0.099 -9999.0 0.0 -0.189 3.0 3.0 CYFIP2 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.065 0.072 -9999.0 0.0 -0.25 1.0 1.0 EGFR -0.034 0.125 -9999.0 0.0 -0.357 2.0 2.0 EPHA2 0.025 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.05 0.082 0.167 1.0 -9999.0 0.0 1.0 CTNNB1 -0.042 0.151 -9999.0 0.0 -0.357 3.0 3.0 ABI1/Sra1/Nap1 0.056 0.021 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.057 0.12 -9999.0 0.0 -0.416 1.0 1.0 CTNND1 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.049 0.082 0.165 1.0 -9999.0 0.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.048 0.081 0.165 1.0 -9999.0 0.0 1.0 EGF -0.039 0.128 -9999.0 0.0 -0.357 2.0 2.0 NCKAP1 0.024 0.028 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.062 0.132 -9999.0 0.0 -0.352 2.0 2.0 cortical microtubule organization 0.012 0.099 -9999.0 0.0 -0.189 3.0 3.0 GO:0000145 -0.047 0.076 0.148 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.016 0.102 -9999.0 0.0 -0.191 3.0 3.0 MLLT4 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.074 0.077 -9999.0 0.0 -0.303 1.0 1.0 ARF6 0.025 0.012 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.047 0.07 -9999.0 0.0 -0.192 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.033 0.084 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.039 0.086 0.167 1.0 -9999.0 0.0 1.0 ARF6/GTP 0.055 0.069 -9999.0 0.0 -0.173 1.0 1.0 CDH1 -0.01 0.097 -9999.0 0.0 -0.357 1.0 1.0 EGFR/EGFR/EGF/EGF -0.067 0.138 -9999.0 0.0 -0.257 5.0 5.0 RhoA/GDP -0.005 0.111 -9999.0 0.0 -0.193 4.0 4.0 actin cytoskeleton organization -0.051 0.081 0.149 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.027 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.024 0.028 -9999.0 0.0 -9999.0 0.0 0.0 DIAPH1 0.024 0.139 -9999.0 0.0 -0.511 1.0 1.0 Wnt receptor signaling pathway -0.012 0.099 0.189 3.0 -9999.0 0.0 3.0 RHOA 0.007 0.094 -9999.0 0.0 -0.357 1.0 1.0 RhoA/GTP -0.079 0.078 -9999.0 0.0 -0.313 1.0 1.0 CTNNA1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.052 0.082 0.151 1.0 -9999.0 0.0 1.0 EFNA1 0.005 0.094 -9999.0 0.0 -0.357 1.0 1.0 LPP -0.052 0.077 0.152 1.0 -9999.0 0.0 1.0 Ephrin A1/EPHA2 -0.0 0.116 -9999.0 0.0 -0.23 3.0 3.0 SEC6/SEC8 -0.056 0.068 -9999.0 0.0 -0.189 3.0 3.0 MGAT3 -0.049 0.081 0.167 1.0 -9999.0 0.0 1.0 HGF/MET -0.002 0.077 -9999.0 0.0 -0.187 2.0 2.0 HGF 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.024 0.081 -9999.0 0.0 -0.192 3.0 3.0 actin cable formation -0.016 0.108 0.236 1.0 -9999.0 0.0 1.0 KIAA1543 -0.069 0.091 0.152 1.0 -9999.0 0.0 1.0 KIFC3 -0.071 0.069 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.048 0.08 0.167 1.0 -9999.0 0.0 1.0 NCK1/GIT1 0.04 0.015 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.012 0.099 -9999.0 0.0 -0.189 3.0 3.0 EXOC4 0.021 0.014 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.055 0.062 -9999.0 0.0 -0.181 3.0 3.0 PIP5K1C -0.05 0.083 0.167 1.0 -9999.0 0.0 1.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.059 0.097 -9999.0 0.0 -0.284 1.0 1.0 adherens junction assembly -0.079 0.144 0.251 1.0 -0.474 1.0 2.0 IGF-1R heterotetramer/IGF1 0.006 0.098 -9999.0 0.0 -0.192 3.0 3.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.046 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.019 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.047 0.083 0.167 1.0 -9999.0 0.0 1.0 mol:GTP 0.045 0.069 -9999.0 0.0 -0.191 1.0 1.0 establishment of epithelial cell apical/basal polarity -0.019 0.105 0.119 4.0 -9999.0 0.0 4.0 cortical actin cytoskeleton stabilization -0.024 0.08 -9999.0 0.0 -0.191 3.0 3.0 regulation of cell-cell adhesion -0.051 0.081 0.149 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.024 0.081 -9999.0 0.0 -0.192 3.0 3.0