rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(3), ATM(8), ATR(13), CCNA1(1), CCND1(1), CCNE1(3), CDKN1A(2), CDKN2A(26), CDKN2B(1), E2F1(2), HDAC1(2), RB1(12), SKP2(2), TFDP1(3), TGFB1(1), TGFB2(3), TP53(144) 8137626 227 156 176 13 28 65 23 40 71 0 5.85e-11 <1.00e-15 <5.13e-14 2 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(3), CDKN2A(26), E2F1(2), MDM2(2), MYC(1), PIK3CA(29), PIK3R1(2), POLR1A(3), POLR1B(2), POLR1D(1), RAC1(1), RB1(12), TBX2(3), TP53(144) 5471186 231 155 167 15 42 56 20 44 69 0 5.87e-11 <1.00e-15 <5.13e-14 3 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(8), ATR(13), BRCA1(12), CCNB1(2), CDC25B(2), CDC25C(1), CDKN1A(2), CHEK1(5), CHEK2(3), EP300(9), GADD45A(1), MDM2(2), MYT1(4), PRKDC(12), RPS6KA1(2), TP53(144), WEE1(4), YWHAQ(1) 11369750 227 152 178 15 31 67 24 47 58 0 1.71e-09 <1.00e-15 <5.13e-14 4 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(17), AKT1(1), ATM(8), BAX(1), CDKN1A(2), CPB2(3), CSNK1A1(2), CSNK1D(2), FHL2(1), GADD45A(1), HIF1A(1), IGFBP3(2), MAPK8(2), MDM2(2), NFKBIB(1), TP53(144) 5574960 190 150 142 8 26 53 19 40 51 1 4.31e-11 <1.00e-15 <5.13e-14 5 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(4), ATM(8), BAX(1), CCND1(1), CCNE1(3), CDKN1A(2), E2F1(2), GADD45A(1), MDM2(2), RB1(12), TP53(144) 4870970 180 148 132 5 16 50 19 38 57 0 5.73e-12 <1.00e-15 <5.13e-14 6 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), CCND1(1), CDKN1A(2), CDKN2A(26), CFL1(2), E2F1(2), MDM2(2), NXT1(1), PRB1(4), TP53(144) 2299938 185 148 134 9 17 52 20 37 59 0 1.84e-11 <1.00e-15 <5.13e-14 7 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(1), EGFR(7), IGF1R(1), MYC(1), POLR2A(2), PRKCA(5), RB1(12), TEP1(7), TERF1(3), TERT(3), TNKS(7), TP53(144), XRCC5(2) 7526196 195 148 146 14 23 52 19 42 59 0 1.46e-09 <1.00e-15 <5.13e-14 8 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(8), ATR(13), CDC25C(1), CHEK1(5), CHEK2(3), TP53(144) 4288732 174 146 126 6 17 48 21 37 51 0 1.75e-09 <1.00e-15 <5.13e-14 9 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(17), DAXX(3), HRAS(4), PAX3(4), RARA(1), RB1(12), SIRT1(1), SP100(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(144) 5147404 193 146 145 14 16 55 22 42 58 0 8.89e-09 <1.00e-15 <5.13e-14 10 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(3), ATM(8), BRCA1(12), CDKN1A(2), CHEK1(5), CHEK2(3), GADD45A(1), JUN(3), MAPK8(2), MDM2(2), MRE11A(1), NFKB1(2), RAD50(3), RAD51(1), RBBP8(1), RELA(3), TP53(144) 7989174 196 143 147 11 27 52 20 42 55 0 4.80e-09 <1.00e-15 <5.13e-14 11 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 IFNG(1), IFNGR1(4), IFNGR2(1), IKBKB(2), JAK2(4), LIN7A(2), NFKB1(2), RB1(12), RELA(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(144), USH1C(7), WT1(4) 4922056 190 143 142 11 18 49 22 43 58 0 6.26e-10 <1.00e-15 <5.13e-14 12 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(2), EIF2S2(1), MAP3K14(1), NFKB1(2), RELA(3), TP53(144) 2621762 153 140 105 5 10 40 19 34 50 0 2.77e-10 <1.00e-15 <5.13e-14 13 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(2), MYC(1), SP1(2), SP3(1), TP53(144), WT1(4) 1887156 154 145 106 9 9 42 20 36 47 0 5.07e-08 1.33e-15 6.31e-14 14 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(1), APAF1(4), ATM(8), BAX(1), BCL2L1(1), CASP7(2), CASP9(3), PRKCA(5), PTK2(6), PXN(3), STAT1(2), TLN1(6), TP53(144) 7347662 186 148 137 16 24 51 22 40 49 0 8.35e-07 1.44e-15 6.35e-14 15 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(8), CDC25B(2), CDC25C(1), CHEK1(5), MYT1(4), RB1(12), TP53(144), WEE1(4) 4718424 180 145 132 7 17 50 20 36 57 0 2.60e-10 2.00e-15 8.21e-14 16 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), FOS(2), JUN(3), KEAP1(23), MAPK1(1), MAPK14(1), MAPK8(2), NFE2L2(28), PRKCA(5) 2396414 66 59 50 3 36 16 3 7 4 0 0.000033 4.99e-12 1.92e-10 17 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(8), ATR(13), BRCA1(12), BRCA2(12), CHEK1(5), CHEK2(3), FANCA(5), FANCC(2), FANCF(3), FANCG(2), MRE11A(1), RAD1(2), RAD17(2), RAD50(3), RAD51(1), RAD9A(2), TP53(144), TREX1(1) 11805494 221 149 173 19 35 57 23 48 58 0 1.07e-06 3.67e-07 0.000013 18 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCNA2(1), CCND1(1), CCNE1(3), CCNE2(2), CDKN2A(26), E2F1(2), PRB1(4) 2445364 40 38 37 2 11 11 3 2 13 0 0.0022 0.000010 0.00035 19 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(3), CKS1B(1), CUL1(4), E2F1(2), RB1(12), RBX1(1), SKP2(2), TFDP1(3), UBE2M(1) 2315424 29 27 29 1 6 10 0 3 10 0 0.0086 0.0015 0.048 20 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCNB1(2), CCND1(1), CCND2(3), CCND3(1), CCNE1(3), CDK7(1), CDKN1A(2), CDKN2A(26), CDKN2B(1), CDKN2C(1), E2F1(2), RB1(12), RBL1(5), TFDP1(3) 4359398 64 54 61 5 14 15 5 7 23 0 0.0024 0.0027 0.083 21 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(1), CCND1(1), CCNE1(3), CDKN1A(2), E2F1(2), HRAS(4), MAPK1(1), MAPK3(1), NFKB1(2), PAK1(2), PIK3CA(29), PIK3R1(2), RAC1(1), RAF1(1), RB1(12), RELA(3), TFDP1(3) 5403902 70 58 57 4 30 15 2 13 10 0 0.000085 0.0031 0.088 22 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(3), CUL1(4), E2F1(2), FBXW7(11), RB1(12), TFDP1(3) 2250276 35 34 33 4 7 10 3 2 13 0 0.091 0.0031 0.088 23 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), CCNE1(3), CUL1(4), E2F1(2), RB1(12), SKP2(2), TFDP1(3) 2312042 27 25 27 1 7 9 0 2 9 0 0.011 0.0078 0.21 24 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(3) 134924 3 3 3 1 0 1 0 2 0 0 0.81 0.026 0.68 25 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(1), RB1(12), SP1(2), SP3(1) 1788188 17 17 17 1 1 5 0 2 9 0 0.12 0.029 0.71 26 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(4), CYP11A1(2), CYP11B1(15), CYP11B2(7), CYP17A1(2), CYP21A2(2), HSD11B1(3), HSD11B2(1), HSD3B1(5), HSD3B2(3) 2527066 45 41 45 7 8 22 1 12 2 0 0.016 0.045 1.00 27 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(4), CYP11A1(2), CYP11B1(15), CYP11B2(7), CYP17A1(2), CYP21A2(2), HSD11B1(3), HSD11B2(1), HSD3B1(5), HSD3B2(3) 2527066 45 41 45 7 8 22 1 12 2 0 0.016 0.045 1.00 28 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(1), AKT3(3), BPNT1(1), ILK(1), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(29), PIK3CD(4), PTEN(16), RBL2(7), SHC1(2), SOS1(11) 5444308 78 64 64 8 33 15 1 18 11 0 0.0019 0.061 1.00 29 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(4), ATM(8), ATR(13), BAI1(11), BAX(1), CASP8(2), CASP9(3), CCNB1(2), CCNB2(1), CCNB3(11), CCND1(1), CCND2(3), CCND3(1), CCNE1(3), CCNE2(2), CCNG1(1), CD82(1), CDKN1A(2), CDKN2A(26), CHEK1(5), CHEK2(3), DDB2(3), EI24(1), FAS(1), GADD45A(1), GADD45B(1), GADD45G(1), GTSE1(4), IGF1(3), IGFBP3(2), LRDD(1), MDM2(2), PPM1D(1), PTEN(16), RFWD2(5), RRM2(1), RRM2B(3), SERPINB5(2), SESN1(3), SESN2(2), SESN3(3), SFN(2), SIAH1(1), STEAP3(2), THBS1(1), TNFRSF10B(1), TP53(144), TSC2(5) 17571626 316 163 263 31 60 86 32 55 83 0 4.94e-10 0.068 1.00 30 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(8), CYP2C9(3) 537026 11 10 11 3 5 3 0 2 1 0 0.55 0.13 1.00 31 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(3), FOS(2), HRAS(4), IGF1(3), IGF1R(1), IRS1(6), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(2), PIK3CA(29), PIK3R1(2), PTPN11(3), RAF1(1), RASA1(8), SHC1(2), SOS1(11), SRF(2) 6592408 85 69 71 7 38 23 2 12 10 0 0.00011 0.15 1.00 32 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(13), PDXP(1), PSAT1(3) 1297976 17 16 17 2 6 5 0 5 1 0 0.13 0.15 1.00 33 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25B(2), CDK7(1), CDKN1A(2), CHEK1(5), NEK1(3), WEE1(4) 1922578 17 17 17 1 7 5 1 3 1 0 0.10 0.23 1.00 34 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(2) 192952 2 2 2 0 0 1 0 0 1 0 0.50 0.27 1.00 35 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(7), GABRA2(12), GABRA3(4), GABRA4(4), GABRA5(6), GABRA6(8), PRKCE(3) 2122650 44 37 44 9 5 16 6 11 6 0 0.22 0.31 1.00 36 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(1), HRAS(4), IGF1R(1), IRS1(6), MAP2K1(2), MAPK1(1), MAPK3(1), PIK3CA(29), PIK3R1(2), RAF1(1), SHC1(2), SOS1(11) 5027788 61 52 48 5 27 18 2 11 3 0 0.00082 0.31 1.00 37 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(4), PGLYRP2(2) 488788 6 5 6 0 1 4 1 0 0 0 0.15 0.32 1.00 38 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), TGDS(1), UGDH(2), UGP2(4), UXS1(4) 1320760 12 11 12 1 5 2 0 3 2 0 0.17 0.36 1.00 39 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(1), BCAR1(6), ILK(1), ITGB1(5), MAPK1(1), MAPK3(1), PDK2(2), PDPK1(1), PIK3CA(29), PIK3R1(2), PTEN(16), PTK2(6), SHC1(2), SOS1(11) 5167874 84 65 70 10 34 18 2 19 11 0 0.0061 0.39 1.00 40 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(5), SPCS1(1), SPCS3(2) 826632 10 9 10 2 2 2 2 0 4 0 0.40 0.41 1.00 41 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(1), HRAS(4), KLK2(2), NTRK1(4), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), SHC1(2), SOS1(11) 4147400 63 50 50 9 30 16 3 9 5 0 0.022 0.44 1.00 42 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IFNG(1), IL12A(1), IL12B(3) 802958 6 6 6 1 3 1 0 0 2 0 0.52 0.48 1.00 43 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(4), CPS1(27), GLS(4), GLUD1(4) 2081354 41 36 40 6 6 19 2 10 4 0 0.063 0.49 1.00 44 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), HBXIP(1), HRAS(4), SHC1(2), SOS1(11) 2356186 19 18 19 1 3 8 2 4 2 0 0.038 0.49 1.00 45 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(5), CA12(2), CA14(1), CA3(4), CA4(1), CA5A(2), CA5B(2), CA6(2), CA7(3), CA9(1), CPS1(27), GLS(4), GLS2(1), GLUD1(4), GLUL(4), HAL(2) 5085282 65 50 64 7 15 28 3 14 5 0 0.0017 0.52 1.00 46 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(1), ACADS(2), ACAT1(2), ECHS1(1), HADHA(2) 1435570 10 10 10 1 0 4 1 3 2 0 0.27 0.52 1.00 47 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(2) 558208 4 4 4 0 1 1 0 2 0 0 0.31 0.53 1.00 48 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(1), GGPS1(2), IDI1(1), IDI2(2), SQLE(3) 1143294 10 9 10 0 3 3 0 4 0 0 0.072 0.60 1.00 49 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(1), PIK3CA(29), PIK3R1(2), PLCB1(8), PLCG1(3), PRKCA(5), VAV1(7) 3391968 55 47 42 8 32 13 2 7 1 0 0.040 0.60 1.00 50 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(3), PLCD1(1), PRKCA(5), TGM2(1) 1332686 10 10 10 1 2 3 1 3 1 0 0.23 0.61 1.00 51 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT2(1), FUT3(3), FUT5(4), FUT6(2) 1364014 11 10 11 2 0 6 4 1 0 0 0.23 0.64 1.00 52 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(3) 452298 3 3 3 1 0 2 1 0 0 0 0.74 0.64 1.00 53 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(1), GH1(2), GHR(3), HRAS(4), IGF1(3), IGF1R(1), PIK3CA(29), PIK3R1(2), SHC1(2), SOD2(1) 3516746 48 42 35 6 26 14 2 6 0 0 0.016 0.65 1.00 54 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), TGDS(1), UGDH(2), UXS1(4) 1041834 8 7 8 0 4 1 0 2 1 0 0.13 0.66 1.00 55 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(1), HLA-DRA(1), HLA-DRB1(2), IL3(1) 804738 5 5 5 0 2 1 0 0 2 0 0.26 0.67 1.00 56 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(1), IDI1(1), SQLE(3) 855824 6 6 6 0 1 2 0 3 0 0 0.21 0.68 1.00 57 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3D(1), CD80(3), CD86(3), CTLA4(1), HLA-DRA(1), HLA-DRB1(2), ICOS(2), ITK(2), LCK(3), PIK3CA(29), PIK3R1(2), PTPN11(3) 3403360 52 45 39 8 29 7 2 10 4 0 0.059 0.72 1.00 58 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(4), NR0B2(1), NR1H3(2), NR1H4(7), RXRA(2) 1458888 17 17 17 4 6 3 1 4 3 0 0.44 0.72 1.00 59 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(1), CD4(1), HLA-DRA(1), HLA-DRB1(2), IL1B(1), IL4(2), IL5RA(3), IL6(1) 1418126 12 11 12 2 2 6 0 1 3 0 0.27 0.73 1.00 60 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(4), GOT2(3), TAT(1), TYR(10) 1254366 18 17 18 4 2 11 0 3 2 0 0.29 0.73 1.00 61 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(2), CBS(4), MUT(4) 1310080 10 9 10 0 3 4 0 1 2 0 0.067 0.74 1.00 62 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(4), GSS(2), NFKB1(2), NOX1(2), RELA(3), TNF(1), XDH(10) 2663058 24 18 24 3 5 10 2 4 3 0 0.059 0.74 1.00 63 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 303668 1 1 1 0 0 0 0 1 0 0 0.79 0.75 1.00 64 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(4), GLS2(1), GLUD1(4), GLUD2(9) 1209154 18 17 18 4 5 7 0 3 3 0 0.45 0.76 1.00 65 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(1), CD80(3), HLA-DRA(1), HLA-DRB1(2), IL10(2), IL4(2) 1056608 11 10 11 3 4 1 1 3 2 0 0.51 0.78 1.00 66 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1), MTMR2(2), MTMR6(5), NFS1(2), TPK1(5) 1724286 15 14 15 2 5 5 1 3 1 0 0.24 0.82 1.00 67 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(3), FOS(2), HRAS(4), INSR(9), IRS1(6), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(2), PIK3CA(29), PIK3R1(2), PTPN11(3), RAF1(1), RASA1(8), SHC1(2), SLC2A4(2), SOS1(11), SRF(2) 6793370 92 72 78 10 38 25 2 15 12 0 0.00038 0.83 1.00 68 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(3), ARG1(2), ASL(4), CKB(1), CKM(2), CKMT2(3), CPS1(27), GATM(1), GLUD1(4), NAGS(1), OAT(1), ODC1(1), OTC(3), PYCR1(1), SMS(2) 4656302 58 47 57 9 12 22 4 11 9 0 0.020 0.86 1.00 69 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(13), NRG2(3), NRG3(9), PRKCA(5), PSEN1(3) 2393032 33 31 33 6 7 12 3 4 7 0 0.22 0.87 1.00 70 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(5), HDC(6), PNMT(2), TH(1), TPH1(2) 1629590 17 16 17 4 6 8 1 1 1 0 0.25 0.88 1.00 71 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), FOSL1(1), FOSL2(1), IFNAR1(2), IFNB1(2), MAPK8(2), NFKB1(2), RELA(3), TNFRSF11A(2), TNFSF11(1), TRAF6(5) 2969574 23 20 23 2 10 9 1 1 2 0 0.061 0.89 1.00 72 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC1A(4), CDC42(1), PAK1(2), PDGFRA(10), PIK3CA(29), PIK3R1(2), RAC1(1), WASL(2) 3577088 51 43 37 7 31 11 1 8 0 0 0.046 0.91 1.00 73 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(3), FOS(2), HRAS(4), JUN(3), KLK2(2), MAP2K1(2), MAPK3(1), MAPK8(2), NGFR(1), PIK3CA(29), PIK3R1(2), PLCG1(3), RAF1(1), SHC1(2), SOS1(11) 5095250 68 55 54 9 36 17 2 11 2 0 0.0099 0.91 1.00 74 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(5), FADS2(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5) 2725002 30 27 30 5 8 11 6 0 5 0 0.095 0.92 1.00 75 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(1), HLA-DRA(1), HLA-DRB1(2) 629408 4 4 4 2 2 0 0 0 2 0 0.78 0.94 1.00 76 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), CHPT1(1), LCMT1(2), LCMT2(2), METTL2B(1), METTL6(2), PCYT1B(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), WBSCR22(3) 3787484 32 28 32 4 7 14 2 3 6 0 0.034 0.95 1.00 77 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), FUT2(1), FUT9(5), GCNT2(2), ST8SIA1(3) 1640626 12 12 12 3 4 4 0 3 1 0 0.45 0.96 1.00 78 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(11), GGT1(1) 1113034 12 10 12 4 2 3 3 2 2 0 0.60 0.96 1.00 79 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(3), TAT(1) 701676 4 4 4 2 1 2 0 1 0 0 0.81 0.97 1.00 80 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(2), ACO2(3), AFMID(1), GRHPR(2), HAO1(7), MDH1(1), MDH2(1), MTHFD1(4), MTHFD1L(2), MTHFD2(4) 3574774 27 25 27 4 10 8 1 4 4 0 0.073 0.97 1.00 81 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(1), GRIA2(7), JUND(2), PPP1R1B(1) 1030442 11 9 11 6 1 5 1 1 3 0 0.87 0.97 1.00 82 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(8), GOT2(3), LDHB(3), LDHC(3) 1828416 17 16 17 4 3 4 1 7 2 0 0.45 0.97 1.00 83 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(2), ACO2(3), GRHPR(2), HAO1(7), MDH1(1), MDH2(1), MTHFD1(4), MTHFD1L(2), MTHFD2(4) 3411370 26 24 26 4 10 8 1 4 3 0 0.089 0.97 1.00 84 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), GSTZ1(2), HGD(4) 600216 7 7 7 4 2 3 0 1 1 0 0.89 0.98 1.00 85 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(3) 440016 4 4 4 2 2 1 0 1 0 0 0.84 0.98 1.00 86 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(2), CD3D(1), CD4(1) 856536 4 4 4 3 0 1 0 1 2 0 0.94 0.98 1.00 87 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(2), JAK2(4), JAK3(7), PIAS1(5), PIAS3(3), PTPRU(7), REG1A(12), SOAT1(1) 3737822 41 32 41 7 13 9 5 10 4 0 0.090 0.98 1.00 88 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CSF1(2), IL6(1), LDLR(4), LPL(3) 1424712 12 12 12 3 5 6 0 1 0 0 0.42 0.98 1.00 89 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(2), RDH11(1), RDH12(2), RDH13(1) 1303138 8 7 8 2 2 2 0 3 1 0 0.48 0.98 1.00 90 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS2(2), DHRSX(4), LCMT1(2), LCMT2(2), METTL2B(1), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), WBSCR22(3) 4026360 35 30 35 5 10 14 2 3 6 0 0.032 0.98 1.00 91 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(5), CA12(2), CA13(1), CA14(1), CA3(4), CA4(1), CA5A(2), CA5B(2), CA6(2), CA7(3), CA9(1), CPS1(27), GLS(4), GLS2(1), GLUD1(4), GLUD2(9), GLUL(4), HAL(2) 5688880 75 56 74 10 18 33 3 14 7 0 0.0038 0.99 1.00 92 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(9), CHKA(4), PDHA1(3), PDHA2(8), SLC18A3(8) 1870780 35 30 35 9 7 14 4 9 1 0 0.27 0.99 1.00 93 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(3), ADORA2A(5), ADORA3(1), P2RY1(3), P2RY2(3), P2RY6(2) 1578504 17 14 17 5 4 9 1 2 1 0 0.20 0.99 1.00 94 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(2), CFL1(2), CFLAR(1) 1023322 5 5 5 2 1 1 0 1 2 0 0.81 0.99 1.00 95 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(3), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFS1(4), NDUFV1(2), NDUFV2(2) 1860990 16 15 16 4 3 4 4 3 2 0 0.55 0.99 1.00 96 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(2), DHRS2(2), DHRSX(4), PON1(6), PON2(1), PON3(1), RDH11(1), RDH12(2), RDH13(1) 2422936 20 17 20 4 6 4 1 7 2 0 0.23 0.99 1.00 97 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(8), CDC25B(2), CDC25C(1), CHEK1(5), MYT1(4), WEE1(4) 3679438 24 22 24 3 8 9 2 3 2 0 0.15 0.99 1.00 98 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(3), FOS(2), HRAS(4), JAK2(4), JUN(3), MAP2K1(2), MAPK3(1), MPL(2), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), RAF1(1), RASA1(8), SHC1(2), SOS1(11), STAT1(2), STAT3(2), STAT5A(2) 7995048 88 69 74 11 39 18 5 14 12 0 0.0042 0.99 1.00 99 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1A(3), BMPR1B(1), BMPR2(1) 1681566 5 5 5 1 0 2 1 2 0 0 0.58 0.99 1.00 100 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(4), APOBEC1(7), APOBEC2(2), APOBEC3F(1), APOBEC4(3) 1961916 17 16 17 4 3 7 0 4 3 0 0.45 0.99 1.00 101 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), FOS(2), FYN(5), JUN(3), MAPK14(1), THBS1(1) 1965654 13 11 12 2 6 3 1 3 0 0 0.30 0.99 1.00 102 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), FURIN(1), NOTCH1(16), PSEN1(3) 2517988 21 19 21 9 1 7 1 4 8 0 0.80 1.00 1.00 103 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(1), BCL2L1(1), CASP9(3), CDC42(1), CHUK(2), H2AFX(1), HRAS(4), MAP2K1(2), MAPK3(1), NFKB1(2), PIK3CA(29), PIK3R1(2), RAC1(1), RAF1(1), RALA(3), RALBP1(1), RALGDS(1), RELA(3) 5098098 59 48 45 9 31 11 2 12 3 0 0.030 1.00 1.00 104 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(6), EGFR(7), HGS(3), TF(6), TFRC(2) 3432552 27 24 26 4 10 10 0 5 2 0 0.14 1.00 1.00 105 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(3), PARK2(10), SNCAIP(3), UBE2E2(2), UBE2G1(1), UBE2G2(1), UBE2L6(1) 1708266 21 20 21 5 5 3 3 6 4 0 0.46 1.00 1.00 106 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT2(1), FUT9(5), GBGT1(2), GLA(2), HEXA(5), NAGA(1), ST3GAL1(4), ST3GAL4(2), ST8SIA1(3) 2686198 25 21 25 5 7 9 1 7 1 0 0.18 1.00 1.00 107 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(1), AKT3(3), BTK(7), CDKN2A(26), GSK3A(3), IARS(3), INPP5D(8), PDK1(1), PIK3CA(29), PPP1R13B(5), PTEN(16), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KB1(1), SFN(2), SHC1(2), SOS1(11), SOS2(7), TEC(4), YWHAB(1), YWHAQ(1) 9691032 141 93 124 19 52 31 5 20 33 0 0.0015 1.00 1.00 108 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), IL6R(1), JAK1(2), JAK2(4), JAK3(7), PIAS3(3), PTPRU(7), REG1A(12), STAT3(2) 4121768 39 32 39 7 12 10 5 7 5 0 0.087 1.00 1.00 109 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(5), CRY1(2), CRY2(2), PER1(5) 2291394 16 14 16 3 5 4 3 3 1 0 0.35 1.00 1.00 110 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3D(1), GZMB(1), HLA-A(7), ICAM1(2), ITGAL(1), ITGB2(5), PRF1(2) 2335004 21 19 21 7 4 5 0 6 5 1 0.47 1.00 1.00 111 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(1), AASS(11), KARS(2) 1263444 15 12 15 5 2 8 1 2 2 0 0.75 1.00 1.00 112 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(1), EHHADH(1), HADHA(2), SDS(2) 1282668 6 6 6 7 1 1 1 1 2 0 1.00 1.00 1.00 113 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A2(4), BCMO1(2), RDH5(1) 1037384 7 7 7 4 2 4 0 0 1 0 0.86 1.00 1.00 114 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2) 2145790 12 11 12 3 3 8 0 0 1 0 0.37 1.00 1.00 115 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2) 2145790 12 11 12 3 3 8 0 0 1 0 0.37 1.00 1.00 116 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(2), CYP11B2(7), CYP17A1(2), HSD11B1(3), HSD11B2(1), HSD3B1(5), HSD3B2(3) 1860634 25 23 25 8 5 11 0 8 1 0 0.41 1.00 1.00 117 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(2), ACP2(1), ACPT(1), ENPP1(8), ENPP3(6), FLAD1(2), TYR(10) 2596664 30 25 30 8 4 16 3 1 6 0 0.44 1.00 1.00 118 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(1), FMOD(2), LUM(2) 966006 6 6 5 3 3 3 0 0 0 0 0.73 1.00 1.00 119 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(8), CCNA1(1), CCNB1(2), CCND1(1), CCND2(3), CCND3(1), CCNE1(3), CCNE2(2), CDK7(1), CDKN1A(2), CDKN2A(26), CDKN2B(1), CDKN2C(1), CREB3(2), CREB3L3(1), CREB3L4(2), E2F1(2), E2F5(2), GADD45A(1), MCM2(1), MCM3(1), MCM4(5), MCM5(6), MCM6(3), MCM7(3), MDM2(2), MYC(1), MYT1(4), ORC1L(3), ORC2L(1), ORC3L(2), ORC5L(3), POLE(7), POLE2(2), PRIM1(3), RB1(12), RBL1(5), RPA1(1), RPA2(1), TFDP1(3), TFDP2(3), TNXB(19), TP53(144), WEE1(4) 20733084 301 159 250 35 52 88 25 54 82 0 2.84e-08 1.00 1.00 120 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLRMT(2) 3599872 15 14 15 2 4 5 0 2 4 0 0.15 1.00 1.00 121 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2) 1501074 9 9 9 3 2 6 0 1 0 0 0.68 1.00 1.00 122 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), GBA3(11), LPO(2), MPO(4), PRDX1(1), PRDX6(2), TPO(10), TYR(10) 2563200 44 36 44 10 9 17 7 7 4 0 0.16 1.00 1.00 123 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), ARG1(2), GLS(4), GLUD1(4), OAT(1), PRODH(1) 1491996 15 14 15 5 2 6 0 5 2 0 0.71 1.00 1.00 124 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(5), CNR2(2), DNMT1(4), MTNR1A(1), MTNR1B(10), PTAFR(3), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(5), PTGIR(1), TBXA2R(2) 3028492 42 37 42 10 9 17 4 11 1 0 0.12 1.00 1.00 125 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(4), ARSB(1), ARSD(1), ARSE(2), CYP11B1(15), CYP11B2(7), HSD11B1(3), HSD11B2(1), HSD3B1(5), HSD3B2(3), SRD5A1(2), SRD5A2(2), STS(6), SULT1E1(1), SULT2A1(3), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2B15(3), UGT2B4(8) 7344102 86 63 86 15 14 36 5 24 7 0 0.012 1.00 1.00 126 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(6), AASDHPPT(1), AASS(11), KARS(2) 1860278 21 17 21 7 3 8 2 5 3 0 0.78 1.00 1.00 127 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(4), GBA3(11), GGT1(1) 1495734 16 14 16 5 3 4 4 3 2 0 0.56 1.00 1.00 128 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), IFNGR1(4), IFNGR2(1), JAK1(2), JAK2(4), STAT1(2) 2202216 14 13 14 4 7 1 2 2 2 0 0.66 1.00 1.00 129 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(2), ACO2(3), FH(2), IDH1(2), MDH1(1), MDH2(1), SDHB(2), SUCLA2(2) 2370248 15 14 15 4 5 6 1 1 2 0 0.50 1.00 1.00 130 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(4), JAK3(7), MAPK1(1), MAPK3(1), STAT3(2), TYK2(8) 3160924 25 22 25 5 6 8 1 6 4 0 0.19 1.00 1.00 131 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(3), GPD2(2), SDHA(3), SDHB(2) 1764158 10 9 10 3 5 2 0 2 1 0 0.65 1.00 1.00 132 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), GPI(5), HK1(3), PFKL(2), PGK1(2), PKLR(4), TPI1(3) 2491822 21 17 21 6 5 9 0 3 4 0 0.30 1.00 1.00 133 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(1), HADH(1), HADHA(2), HADHB(3), HSD17B4(1), PPT1(1), PPT2(1) 2273060 11 11 11 3 4 3 0 2 2 0 0.55 1.00 1.00 134 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNB1(2), JAK1(2), PTPRU(7), REG1A(12), STAT1(2), STAT2(1), TYK2(8) 3356902 36 32 36 9 12 11 5 3 5 0 0.27 1.00 1.00 135 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(2), F13B(12), HSD17B1(1), HSD17B4(1), HSD17B7(1), HSD3B1(5), HSD3B2(3) 2178186 25 24 25 7 8 8 1 7 1 0 0.47 1.00 1.00 136 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(2), IL1B(1), MST1(2), MST1R(3), TNF(1) 1764336 9 9 9 3 3 5 0 1 0 0 0.55 1.00 1.00 137 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD4(1), FYN(5), HLA-DRA(1), HLA-DRB1(2), LCK(3), PTPRC(7), ZAP70(4) 2430056 24 19 24 6 8 5 3 6 2 0 0.47 1.00 1.00 138 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(5), HK1(3), HK2(5), HK3(5), IMPA1(2), PGM1(1), TGDS(1) 2747252 22 19 22 5 7 10 0 3 2 0 0.23 1.00 1.00 139 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(3), CASP8(2), FADD(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1) 2267008 12 10 12 6 4 3 1 0 4 0 0.86 1.00 1.00 140 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(2), CD3D(1), CD4(1), CD58(1), CD8A(2), IL3(1), IL6(1) 1659316 10 9 10 6 1 4 0 3 2 0 0.92 1.00 1.00 141 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 FUT2(1), FUT9(5), GBGT1(2), GLA(2), HEXA(5), NAGA(1), ST3GAL1(4), ST8SIA1(3) 2851204 23 20 23 5 6 9 1 6 1 0 0.21 1.00 1.00 142 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(2), ITGAL(1), ITGAM(7), ITGB2(5), SELE(4), SELL(2) 2812044 26 23 26 6 7 8 2 7 2 0 0.25 1.00 1.00 143 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 CPO(1), FECH(2), GATA1(3), HBB(2), UROD(1), UROS(1) 2116598 10 10 10 3 2 5 0 1 2 0 0.53 1.00 1.00 144 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD4(1), CD8A(2), CSF1(2), IL3(1), IL4(2), IL6(1), IL7(1) 1604136 10 9 10 7 0 6 0 2 2 0 0.93 1.00 1.00 145 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(3), PRKCA(5) 1788188 11 11 11 4 3 4 2 1 1 0 0.71 1.00 1.00 146 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 CPOX(2), FECH(2), PPOX(1), UROD(1), UROS(1) 2042372 7 7 7 2 3 3 0 0 1 0 0.56 1.00 1.00 147 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNG(1), IFNGR1(4), JAK1(2), JAK2(4), PLA2G2A(1), PTPRU(7), REG1A(12), STAT1(2) 3095954 33 28 33 8 14 4 6 5 4 0 0.40 1.00 1.00 148 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(5), ICAM1(2), ITGA4(4), ITGAL(1), ITGB1(5), ITGB2(5), SELE(4), SELL(2) 3262562 28 21 28 5 6 10 1 9 2 0 0.17 1.00 1.00 149 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), ECHS1(1), EHHADH(1), GCDH(2), HADHA(2), SDHB(2), SDS(2) 2076904 12 11 12 8 3 2 2 2 3 0 0.98 1.00 1.00 150 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(2), IFNG(1), IL10(2), IL12A(1), IL12B(3), IL16(5), IL1A(1), IL3(1), IL4(2), IL6(1), LTA(2), TNF(1) 2651310 23 21 23 6 7 8 1 6 1 0 0.41 1.00 1.00 151 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CSAD(2), GAD1(5), GAD2(6), GGT1(1) 1508728 16 13 16 9 7 6 0 2 1 0 0.90 1.00 1.00 152 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(1), EIF2B5(3), EIF2S2(1), IGF1(3), IGF1R(1), INPPL1(4), PDK2(2), PDPK1(1), PIK3CA(29), PIK3R1(2), PTEN(16), RPS6(1), RPS6KB1(1) 5268088 65 55 51 11 32 11 2 8 12 0 0.065 1.00 1.00 153 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(8), CARS2(1), GOT2(3), LDHAL6A(2), LDHAL6B(1), LDHB(3), LDHC(3), SDS(2), SULT1B1(4), SULT1C2(4), SULT1C4(1) 3371320 32 25 32 7 11 5 4 9 3 0 0.31 1.00 1.00 154 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(2), PSMC3(2), PSMD14(3), RPN1(1), UBE2A(2), UBE3A(6) 3460142 19 19 19 4 6 10 0 1 2 0 0.34 1.00 1.00 155 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(4), MMP14(2), MMP2(3), MMP9(6), RECK(3), TIMP2(1), TIMP4(1) 2007484 20 17 20 5 2 13 2 2 1 0 0.35 1.00 1.00 156 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(1), CYP2A6(5), CYP2A7(1), NAT2(2), XDH(10) 2127990 20 18 20 7 4 9 1 3 3 0 0.50 1.00 1.00 157 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(1), AKT3(3), CDKN1A(2), HRAS(4), MAP2K1(2), MAP2K2(1), NGFR(1), NTRK1(4), PIK3CA(29), PIK3CD(4), SHC1(2), SOS1(11) 4370612 64 52 51 13 27 21 2 10 4 0 0.069 1.00 1.00 158 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), MIOX(1), UGDH(2) 2290148 12 12 12 4 5 6 0 0 1 0 0.53 1.00 1.00 159 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(3), FOS(2), HRAS(4), IL6(1), IL6R(1), IL6ST(1), JAK1(2), JAK2(4), JAK3(7), JUN(3), MAP2K1(2), MAPK3(1), PTPN11(3), RAF1(1), SHC1(2), SOS1(11), SRF(2), STAT3(2) 6405864 52 43 51 9 16 16 3 11 6 0 0.068 1.00 1.00 160 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), ADSS(1), HPRT1(1), IMPDH1(2), MTHFD2(4), POLB(1), POLD1(2), POLG(2), PRPS2(1), RRM1(1) 3386628 16 14 16 3 4 5 0 6 1 0 0.28 1.00 1.00 161 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(2), EPOR(2), GRIN1(1), HIF1A(1), JAK2(4), NFKB1(2), RELA(3), SOD2(1) 3407454 17 13 17 4 2 6 2 4 3 0 0.40 1.00 1.00 162 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(1), ENO3(1), FARS2(2), GOT2(3), PAH(3), TAT(1), YARS(1) 2210582 12 11 12 4 3 5 0 3 1 0 0.58 1.00 1.00 163 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(8), CKM(2), FBL(2), GPT(1), LDHB(3), LDHC(3), MAPK14(1), NCL(1) 2363662 21 19 21 5 6 9 1 3 2 0 0.36 1.00 1.00 164 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPN1(2), CAPNS2(1), CDK5(1), CDK5R1(1), CSNK1A1(2), CSNK1D(2), MAPT(4) 2547536 14 14 14 4 5 5 0 0 4 0 0.58 1.00 1.00 165 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), GBA(4), GBA3(11), LPO(2), MPO(4), PRDX6(2), TPO(10) 2229272 37 31 37 10 9 11 7 8 2 0 0.34 1.00 1.00 166 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(4), ST3GAL4(2), ST3GAL5(2), ST6GALNAC4(1), ST8SIA1(3) 1515492 13 12 13 6 5 5 1 1 1 0 0.73 1.00 1.00 167 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDFT1(1), FDPS(1), HMGCR(1), IDI1(1), LSS(2), MVD(1), SC5DL(1), SQLE(3) 2981678 14 13 14 4 2 6 0 6 0 0 0.55 1.00 1.00 168 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(5), HK1(3), HK2(5), HK3(5), IMPA1(2), PGM1(1), TGDS(1) 3131198 22 19 22 5 7 10 0 3 2 0 0.21 1.00 1.00 169 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS2(1), SULT1A2(2), SULT1E1(1), SULT2A1(3) 1626208 8 8 8 4 2 3 0 2 1 0 0.88 1.00 1.00 170 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), GCK(5), GFPT1(1), GNE(2), GNPDA2(4), HEXA(5), HK1(3), HK2(5), HK3(5), RENBP(2), UAP1(2) 4515504 36 28 36 8 9 16 0 5 6 0 0.20 1.00 1.00 171 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(14), RANGAP1(4) 2248318 18 16 18 5 4 5 2 4 3 0 0.82 1.00 1.00 172 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(2), GHR(3), HRAS(4), INSR(9), IRS1(6), JAK2(4), MAP2K1(2), MAPK1(1), MAPK3(1), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), RAF1(1), RPS6KA1(2), SHC1(2), SLC2A4(2), SOS1(11), SRF(2), STAT5A(2) 8828800 93 73 80 15 35 30 6 15 7 0 0.0062 1.00 1.00 173 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(13), CD38(2), ENPP1(8), ENPP3(6), NADSYN1(7), NMNAT2(2), NNT(10), NT5E(2) 3894640 50 39 50 10 12 20 2 10 6 0 0.12 1.00 1.00 174 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL13RA2(1), IL4R(2), JAK1(2), JAK2(4), TYK2(8) 2804212 19 18 19 6 6 5 3 1 4 0 0.63 1.00 1.00 175 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL13RA2(1), IL4R(2), JAK1(2), JAK2(4), TYK2(8) 2804212 19 18 19 6 6 5 3 1 4 0 0.63 1.00 1.00 176 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(18), GNA12(2), PRKACB(3), PRKACG(1), PRKAR2B(2) 2708804 26 24 26 6 7 12 0 6 1 0 0.34 1.00 1.00 177 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(4), MBTPS1(3), MBTPS2(3), SCAP(4), SREBF1(2), SREBF2(3) 3208272 20 19 20 5 9 5 1 4 1 0 0.33 1.00 1.00 178 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(17), EP300(9), FYN(5), IL2RG(1), IL7(1), IL7R(8), JAK1(2), JAK3(7), LCK(3), NMI(2), PIK3CA(29), PIK3R1(2), STAT5A(2) 7512846 88 63 73 15 31 22 4 23 8 0 0.019 1.00 1.00 179 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(2), ITPKA(1), ITPKB(6) 1647212 9 9 9 5 3 3 1 1 1 0 0.85 1.00 1.00 180 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(2), PLCB1(8), PRKCA(5), RELA(3) 2193316 18 15 18 5 5 6 2 3 2 0 0.60 1.00 1.00 181 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(4), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3) 4028318 25 23 25 7 6 4 2 6 7 0 0.50 1.00 1.00 182 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(4), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3) 4028318 25 23 25 7 6 4 2 6 7 0 0.50 1.00 1.00 183 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(4), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3) 4028318 25 23 25 7 6 4 2 6 7 0 0.50 1.00 1.00 184 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(10), AKT1(1), BAX(1), BCL2L1(1), CSF2RB(5), IGF1(3), IGF1R(1), IL3(1), KIT(7), PIK3CA(29), PIK3R1(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2) 5837154 71 57 58 13 34 17 2 15 3 0 0.026 1.00 1.00 185 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(10), AKT1(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CREB1(1), GNAS(6), HRAS(4), MAPK1(1), MAPK14(1), MAPK3(1), PIK3CA(29), PIK3R1(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), PRKCA(5), RAC1(1), RPS6KA1(2), RPS6KA5(4), SOS1(11) 7760444 93 73 80 15 38 22 6 21 6 0 0.022 1.00 1.00 186 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAP3K14(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(3), TNFRSF13B(1), TNFRSF17(1), TNFSF13(1), TRAF3(3), TRAF5(2), TRAF6(5) 3889122 24 21 24 8 6 5 1 5 7 0 0.73 1.00 1.00 187 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), CREBBP(17), DFFB(2), GZMA(4), GZMB(1), HMGB2(1), PRF1(2) 2838388 28 25 28 9 5 10 2 7 4 0 0.62 1.00 1.00 188 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(6), GNB1(1), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), PRKCA(5) 2558750 24 23 24 9 9 6 1 5 3 0 0.85 1.00 1.00 189 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(10), GNAS(6), GNB1(1), PRKAR1A(2) 1743866 19 18 19 7 6 5 2 5 1 0 0.77 1.00 1.00 190 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(8), G6PD(1), GCLC(2), GCLM(1), GGT1(1), GPX5(2), GSS(2), GSTA1(3), GSTA2(2), GSTA4(1), GSTM3(1), GSTM4(3), GSTM5(3), GSTP1(1), GSTZ1(2), IDH1(2), MGST1(2), PGD(1) 4784818 38 35 38 8 8 22 1 6 1 0 0.092 1.00 1.00 191 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAA2(1), ACAT1(2), ECHS1(1), EHHADH(1), HADHA(2), HADHB(3), SDS(2) 2216812 13 13 13 7 3 4 1 3 2 0 0.93 1.00 1.00 192 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(2), IFNA1(1), IFNB1(2), IFNG(1), IL10(2), IL12A(1), IL12B(3), IL1A(1), IL3(1), IL4(2), IL6(1), IL7(1), LTA(2), TGFB1(1), TGFB2(3), TNF(1) 3533122 29 26 29 8 9 9 1 6 4 0 0.37 1.00 1.00 193 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST2(2), HS3ST3A1(1), XYLT1(5) 1790680 8 7 8 4 1 5 0 2 0 0 0.74 1.00 1.00 194 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST2(2), HS3ST3A1(1), XYLT1(5) 1790680 8 7 8 4 1 5 0 2 0 0 0.74 1.00 1.00 195 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(2), CPT1A(5), LEPR(15), PRKAA2(5), PRKAB2(1), PRKAG2(4) 3865270 32 28 32 7 6 10 4 7 5 0 0.35 1.00 1.00 196 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), GUSB(2), UCHL3(1), UGDH(2), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2B15(3), UGT2B4(8) 4733732 35 30 35 8 4 15 4 11 1 0 0.31 1.00 1.00 197 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(4), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), FDXR(2) 4288020 27 25 27 7 7 5 2 6 7 0 0.40 1.00 1.00 198 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 UBE2A(2), UBE2C(1), UBE2D1(1), UBE2D2(2), UBE2E3(2), UBE2G1(1), UBE2G2(1), UBE2J1(2), UBE2L6(1), UBE2M(1), UBE3A(6) 2812044 20 19 20 6 5 9 0 3 3 0 0.64 1.00 1.00 199 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(1), ATF2(3), CDC42(1), DLD(2), DUSP10(4), DUSP4(2), DUSP8(1), GAB1(2), GADD45A(1), GCK(5), IL1R1(1), JUN(3), MAP2K4(1), MAP2K5(1), MAP2K7(1), MAP3K1(3), MAP3K11(2), MAP3K12(4), MAP3K13(5), MAP3K3(1), MAP3K4(4), MAP3K5(4), MAP3K7(2), MAP3K9(4), MAPK10(1), MAPK7(1), MAPK8(2), MAPK9(1), MYEF2(4), NFATC3(6), NR2C2(3), PAPPA(8), SHC1(2), TP53(144), TRAF6(5) 13436330 235 153 186 33 46 74 21 43 51 0 0.000072 1.00 1.00 200 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(2), CDC25B(2), CDC25C(1), PRKCA(5) 2455154 10 10 10 4 3 2 2 1 2 0 0.83 1.00 1.00 201 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3D(1), IFNG(1), IL4(2), TGFB1(1), TGFB2(3), TGFBR2(3), TGFBR3(8) 2835718 19 17 19 9 7 5 0 4 3 0 0.88 1.00 1.00 202 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(2), SEC61A2(1), SRP54(1), SRP72(2), SRPR(2) 1998228 8 8 8 3 2 3 2 1 0 0 0.81 1.00 1.00 203 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(6), EGFR(7), ERBB3(4), NRG1(3), UBE2D1(1) 2755796 21 19 20 6 5 7 0 6 3 0 0.53 1.00 1.00 204 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(2), IFNB1(2), JAK1(2), STAT1(2), STAT2(1), TYK2(8) 2901578 18 18 18 6 6 7 1 1 3 0 0.61 1.00 1.00 205 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(10), ARHGEF1(2), F2R(2), F2RL3(1), GNA12(2), GNA13(1), GNAI1(3), GNB1(1), MAP3K7(2), PIK3CA(29), PIK3R1(2), PLCB1(8), PPP1R12B(5), PRKCA(5), ROCK1(5) 6958910 78 60 65 14 36 20 4 15 3 0 0.041 1.00 1.00 206 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CBS(4), GGT1(1), MARS(1), MAT1A(1), PAPSS2(1), SCLY(1), SEPHS1(3) 3302078 13 11 13 7 4 5 0 0 4 0 0.87 1.00 1.00 207 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(3), ARPC1A(4), CDC42(1), RAC1(1), WASF1(1), WASL(2) 2167862 12 12 11 8 5 5 0 1 1 0 0.98 1.00 1.00 208 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(4), ARHGAP5(2), ARHGDIB(2), CASP1(1), CASP10(3), CASP8(2), CASP9(3), GZMB(1), JUN(3), PRF1(2) 3437714 23 18 21 9 10 3 1 5 4 0 0.87 1.00 1.00 209 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSA(5), GOT2(3), PAH(3), TAT(1), YARS(1), YARS2(2) 2328418 17 15 17 6 4 9 0 3 1 0 0.62 1.00 1.00 210 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(5), FOS(2), HRAS(4), IL3(1), JAK2(4), MAP2K1(2), MAPK3(1), RAF1(1), SHC1(2), SOS1(11), STAT5A(2) 4723942 35 32 35 8 7 14 3 7 4 0 0.26 1.00 1.00 211 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(2), CDC25B(2), CDC25C(1), CDK7(1), SHH(2), XPO1(2) 2359034 10 10 10 4 2 2 1 4 1 0 0.86 1.00 1.00 212 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IL2RG(1), IL4(2), IL4R(2), IRS1(6), JAK1(2), JAK3(7), RPS6KB1(1), SHC1(2), STAT6(2) 3963348 26 22 26 7 5 11 1 5 4 0 0.37 1.00 1.00 213 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BRAF(8), CREB1(1), CREB3(2), CREB5(3), MAPK1(1), RAF1(1), SNX13(5) 3061778 21 19 21 7 8 6 1 3 3 0 0.72 1.00 1.00 214 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(2), PSMB8(2) 2332334 7 7 7 3 4 2 0 0 1 0 0.80 1.00 1.00 215 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(2), HLA-A(7), ITGB1(5), KLRC1(1), KLRC3(2), KLRD1(1), MAP2K1(2), MAPK3(1), PAK1(2), PIK3CA(29), PIK3R1(2), RAC1(1), SYK(1), VAV1(7) 4974032 63 51 50 12 32 12 1 12 5 1 0.086 1.00 1.00 216 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(4), BAK1(1), BAX(1), BCL2L1(1), BIRC2(1), BIRC3(3), CASP7(2), CASP8(2), CASP9(3), DFFB(2) 3649000 20 17 19 6 6 4 1 5 4 0 0.70 1.00 1.00 217 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(3), F13A1(5), F2R(2), FGA(5), FGB(4), FGG(2), PLAT(1), PLAU(2), PLG(2), SERPINB2(4) 3577800 30 25 30 8 6 10 4 6 4 0 0.51 1.00 1.00 218 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(4), BAK1(1), BAX(1), BCL2L1(1), BIRC2(1), BIRC3(3), CASP2(1), CASP7(2), CASP8(2), CASP9(3), FADD(1), FAS(1), FASLG(1), GZMB(1), JUN(3), MAP2K4(1), MAP3K1(3), MAP3K14(1), MAPK10(1), MCL1(2), MDM2(2), MYC(1), NFKB1(2), PARP1(3), PRF1(2), RELA(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(144), TRADD(1), TRAF1(4) 10027808 200 147 150 32 28 53 21 42 56 0 0.0015 1.00 1.00 219 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(3), EPOR(2), FOS(2), HRAS(4), JAK2(4), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(2), PLCG1(3), RAF1(1), SHC1(2), SOS1(11), STAT5A(2) 5746908 42 35 41 9 14 13 3 8 4 0 0.19 1.00 1.00 220 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(17), ABCB11(6), ABCB4(7), ABCC1(5), ABCC3(3), GSTP1(1) 3832518 39 27 39 10 14 13 5 5 1 1 0.19 1.00 1.00 221 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(2), DFFB(2), GZMB(1), HMGB2(1), TOP2A(2), TOP2B(4) 2569430 12 11 12 6 3 4 2 2 1 0 0.96 1.00 1.00 222 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(1), CDK5R1(1), EGR1(2), HRAS(4), KLK2(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1) 2221262 17 17 17 6 5 8 1 3 0 0 0.52 1.00 1.00 223 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(1), CREB1(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(2), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), NFKB1(2), PIK3CA(29), PIK3R1(2), RB1(12), RELA(3), SP1(2) 5184784 66 57 53 12 26 17 1 12 10 0 0.12 1.00 1.00 224 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABARAP(1), GABRA1(7), GABRA2(12), GABRA3(4), GABRA4(4), GABRA5(6), GABRA6(8), GPHN(2), NSF(2), UBQLN1(2) 3194388 50 41 50 12 9 16 6 12 7 0 0.35 1.00 1.00 225 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), ECHS1(1), EHHADH(1), HADHA(2), SDS(2) 3248678 18 16 18 8 4 9 1 1 3 0 0.78 1.00 1.00 226 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(8), EIF2AK4(7), EIF2B5(3), EIF2S2(1), EIF5(3) 3106812 22 21 22 7 9 8 0 3 2 0 0.68 1.00 1.00 227 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(2), CHST12(1), PAPSS2(1), SULT1A1(2), SULT1A2(2), SULT1E1(1), SULT2A1(3) 2467258 13 13 13 6 2 5 0 5 1 0 0.83 1.00 1.00 228 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(3), FH(2), MDH1(1), OGDH(3), SDHA(3), SUCLA2(2) 2500188 14 14 14 7 3 6 1 3 1 0 0.88 1.00 1.00 229 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(3), LARS(1), LARS2(3), PDHA1(3), PDHA2(8) 2675874 19 17 19 7 4 7 2 5 1 0 0.81 1.00 1.00 230 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(2), POLD2(1), POLE(7), POLG(2), POLL(2), POLQ(18) 4461926 33 27 33 7 11 12 1 7 2 0 0.18 1.00 1.00 231 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(2), IKBKAP(4), IKBKB(2), MAP3K1(3), MAP3K14(1), NFKB1(2), RELA(3), TNFAIP3(5), TRAF3(3), TRAF6(5) 4832344 30 26 30 7 5 10 1 8 6 0 0.40 1.00 1.00 232 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(17), EP300(9), ESR1(6), MAPK1(1), MAPK3(1) 3931486 34 29 33 9 5 11 2 12 4 0 0.46 1.00 1.00 233 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(3), EGF(6), EGFR(7), FOS(2), HRAS(4), JAK1(2), JUN(3), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK3(1), MAPK8(2), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), RAF1(1), RASA1(8), SHC1(2), SOS1(11), SRF(2), STAT1(2), STAT3(2), STAT5A(2) 9991852 105 78 90 16 45 26 4 17 13 0 0.0077 1.00 1.00 234 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM2(1), CD3D(1), FOS(2), FYN(5), HRAS(4), JUN(3), LCK(3), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK3(1), MAPK8(2), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NFKB1(2), PIK3CA(29), PIK3R1(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(5), PTPN7(1), RAC1(1), RAF1(1), RASA1(8), RELA(3), SHC1(2), SOS1(11), SYT1(4), VAV1(7), ZAP70(4) 12751030 136 86 122 21 54 38 9 21 14 0 0.0025 1.00 1.00 235 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(1), CASP9(3), CHUK(2), GH1(2), GHR(3), NFKB1(2), PDPK1(1), PIK3CA(29), PIK3R1(2), RELA(3) 3731592 48 39 34 10 28 7 3 8 2 0 0.26 1.00 1.00 236 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(1), EIF4A1(5), EIF4A2(2), EIF4B(5), EIF4G1(10), EIF4G2(3), EIF4G3(4), PDK2(2), PDPK1(1), PIK3CA(29), PIK3R1(2), PTEN(16), RPS6(1), RPS6KB1(1), TSC1(5), TSC2(5) 7417794 92 68 78 16 43 18 4 12 15 0 0.057 1.00 1.00 237 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CAMKK2(1), CREB1(1), SYT1(4) 3108592 17 16 17 9 3 6 4 2 2 0 0.95 1.00 1.00 238 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(2), ACOX3(5), ELOVL5(2), ELOVL6(1), FADS1(1), FADS2(1), FASN(2), HADHA(2), HSD17B12(2), PECR(1), SCD(1) 3850318 21 18 21 9 4 8 3 2 4 0 0.68 1.00 1.00 239 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(3), ARG1(2), ASL(4), CKB(1), CKM(2), CKMT2(3), CPS1(27), DAO(2), EPRS(12), GATM(1), GLUD1(4), GLUD2(9), GOT2(3), LAP3(1), NOS1(11), NOS3(2), OAT(1), OTC(3), P4HA1(2), P4HA2(3), P4HA3(3), PARS2(4), PRODH(1), PYCR1(1), RARS(4), RARS2(2) 9618052 111 76 110 21 27 45 4 18 17 0 0.012 1.00 1.00 240 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10(2), IL10RA(2), IL1A(1), IL6(1), JAK1(2), STAT1(2), STAT3(2), STAT5A(2), TNF(1) 3264164 17 16 17 8 6 6 1 2 2 0 0.80 1.00 1.00 241 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(1), ACADS(2), ACADVL(1), ACSL1(2), ACSL3(2), ACSL4(2), CPT1A(5), CPT2(2), DCI(1), EHHADH(1), HADHA(2), PECR(1), SCP2(1), SLC25A20(1) 4472962 26 26 26 7 4 7 2 8 5 0 0.49 1.00 1.00 242 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(3), FOS(2), HRAS(4), JAK1(2), JUN(3), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK3(1), MAPK8(2), PDGFRA(10), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), RAF1(1), RASA1(8), SHC1(2), SOS1(11), SRF(2), STAT1(2), STAT3(2), STAT5A(2) 9303882 102 75 88 18 45 26 5 15 11 0 0.026 1.00 1.00 243 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(4), BAK1(1), BAX(1), BCL2L1(1), CASP8AP2(6), CASP9(3), CES1(2) 3046114 18 14 17 5 6 3 2 6 1 0 0.70 1.00 1.00 244 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(1), EIF4A1(5), EIF4A2(2), EIF4G1(10), EIF4G2(3), EIF4G3(4), GHR(3), IRS1(6), MAPK1(1), MAPK14(1), MAPK3(1), PABPC1(4), PDK2(2), PDPK1(1), PIK3CA(29), PIK3R1(2), PRKCA(5), PTEN(16), RPS6KB1(1) 7500386 97 71 83 17 43 21 6 15 12 0 0.069 1.00 1.00 245 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), AKR1D1(4), ARSD(1), ARSE(2), CARM1(1), CYP11B1(15), CYP11B2(7), CYP19A1(4), HSD11B1(3), HSD11B2(1), HSD17B1(1), HSD17B12(2), HSD17B7(1), HSD3B1(5), HSD3B2(3), LCMT1(2), LCMT2(2), METTL2B(1), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), SRD5A1(2), SRD5A2(2), STS(6), SULT1E1(1), SULT2A1(3), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(3), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2), WBSCR22(3) 13534764 146 86 146 24 29 56 11 34 16 0 0.00091 1.00 1.00 246 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(5), ICAM1(2), ITGA4(4), ITGAL(1), ITGAM(7), ITGB1(5), ITGB2(5), SELE(4), SELL(2), SELP(11) 4296920 46 32 46 10 11 17 2 11 5 0 0.18 1.00 1.00 247 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(1), AKT3(3), IARS(3), IL13RA1(2), IL2RG(1), IL4(2), IL4R(2), INPP5D(8), JAK1(2), JAK2(4), JAK3(7), NR0B2(1), PI3(1), PIK3CA(29), PPP1R13B(5), RPS6KB1(1), SERPINA4(7), SHC1(2), SOS1(11), SOS2(7), STAT6(2), TYK2(8) 9888078 109 76 96 20 42 29 4 21 13 0 0.018 1.00 1.00 248 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(8), G6PD(1), GCLC(2), GCLM(1), GGT1(1), GPX5(2), GPX6(2), GSR(4), GSS(2), GSTA1(3), GSTA2(2), GSTA4(1), GSTA5(2), GSTM3(1), GSTM4(3), GSTM5(3), GSTP1(1), GSTZ1(2), IDH1(2), MGST1(2), OPLAH(5) 5776278 50 46 50 11 11 27 0 10 2 0 0.074 1.00 1.00 249 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(1), CREB1(1), HRAS(4), MAPK1(1), MAPK3(1), MAPK7(1), MEF2A(3), MEF2C(4), MEF2D(3), NTRK1(4), PIK3CA(29), PIK3R1(2), PLCG1(3), RPS6KA1(2), SHC1(2) 5093470 61 50 48 14 30 18 2 8 3 0 0.13 1.00 1.00 250 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2) 3563382 19 19 19 7 5 12 0 1 1 0 0.65 1.00 1.00 251 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(11), AP2A1(2), AP2M1(1), CALM2(1), DNM1(2), EPN1(3), EPS15(5), PICALM(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), SYNJ1(4), SYNJ2(3), SYT1(4) 5790874 50 44 49 10 17 14 4 6 9 0 0.19 1.00 1.00 252 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACO1(2), ACO2(3), ACSS1(3), FH(2), IDH1(2), MDH1(1), MDH2(1), SUCLA2(2) 3541310 16 16 16 7 5 7 1 2 1 0 0.80 1.00 1.00 253 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(3), CHUK(2), IFNG(1), IKBKB(2), IL4(2), JUN(3), MAP3K1(3), MAP3K5(4), MAP4K5(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(3), TNFRSF9(1) 5181046 30 25 29 9 10 7 2 7 4 0 0.62 1.00 1.00 254 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(3), FDFT1(1), FDPS(1), HMGCR(1), HMGCS1(1), IDI1(1), LSS(2), MVD(1), NSDHL(1), SC5DL(1), SQLE(3) 3548964 16 15 16 5 4 6 0 6 0 0 0.62 1.00 1.00 255 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(1), CHRNB1(1), CHRNG(4), MUSK(2), PIK3CA(29), PIK3R1(2), PTK2(6), RAPSN(3), TERT(3) 4346226 51 43 38 13 32 12 0 6 1 0 0.17 1.00 1.00 256 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(2), PSMC2(4), PSMC3(2), PSMD1(4), PSMD11(1), PSMD12(1), PSMD13(1), PSMD2(1) 4260252 19 16 19 8 4 10 1 3 1 0 0.84 1.00 1.00 257 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR7(3), FDFT1(1), FDPS(1), GGPS1(2), HMGCR(1), HSD17B7(1), IDI1(1), IDI2(2), LSS(2), MVD(1), NSDHL(1), SC5DL(1), SQLE(3), TM7SF2(1) 5196354 21 19 21 6 5 8 1 7 0 0 0.48 1.00 1.00 258 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(10), AKT1(1), GNAI1(3), GNB1(1), ITGAV(4), ITGB3(4), MAPK1(1), MAPK3(1), PDGFRA(10), PIK3CA(29), PIK3R1(2), PLCB1(8), PRKCA(5), PTK2(6), RAC1(1), SMPD1(4), SMPD2(1) 7326480 91 67 78 20 41 24 5 20 1 0 0.094 1.00 1.00 259 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(1), ARFGEF2(3), CLTA(1), COPA(8), GBF1(6), GPLD1(1), KDELR2(1) 4298344 22 20 22 9 9 6 0 6 1 0 0.80 1.00 1.00 260 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(3), EGF(6), EGFR(7), HRAS(4), MAP2K1(2), MAPK1(1), MAPK3(1), PTPRB(17), RAF1(1), RASA1(8), SHC1(2), SOS1(11), SPRY2(1), SPRY3(4) 6691020 68 55 67 15 16 22 4 13 13 0 0.19 1.00 1.00 261 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(2), ATG7(6), BECN1(2), GABARAP(1), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNG(1), PIK3C3(5), PIK3R4(7), PRKAA2(5), ULK1(4), ULK2(5) 5670902 53 44 52 11 21 12 4 8 8 0 0.21 1.00 1.00 262 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(4), BAK1(1), BAX(1), BCL2L1(1), BIRC2(1), BIRC3(3), CASP1(1), CASP10(3), CASP2(1), CASP4(4), CASP7(2), CASP8(2), CASP9(3), CHUK(2), DFFB(2), FADD(1), FAS(1), FASLG(1), GZMB(1), IKBKB(2), IRF1(1), IRF3(1), IRF4(2), IRF6(6), JUN(3), LTA(2), MAP2K4(1), MAP3K1(3), MAPK10(1), MDM2(2), MYC(1), NFKB1(2), NFKBIB(1), NFKBIE(1), PRF1(2), RELA(3), TNF(1), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TP53(144), TRADD(1), TRAF1(4), TRAF3(3) 15474074 229 152 179 36 32 59 24 49 65 0 0.00040 1.00 1.00 263 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(9), CALCR(10), CALCRL(3), CRHR1(3), CRHR2(3), ELTD1(18), EMR1(11), EMR2(4), GHRHR(4), GLP1R(1), GLP2R(5), GPR64(5), LPHN1(3), LPHN2(7), LPHN3(17), SCTR(1), VIPR2(3) 7205974 107 68 107 29 33 31 9 22 12 0 0.15 1.00 1.00 264 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(2), CREBBP(17), EP300(9), FADD(1), HDAC3(1), IKBKB(2), NFKB1(2), RELA(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(5) 5997354 47 38 46 10 11 14 4 10 8 0 0.19 1.00 1.00 265 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(3), ACVR1C(4), AKT1(1), AKT3(3), ARRB1(2), ATF2(3), ATF4(2), BDNF(1), BRAF(8), CACNA1A(10), CACNA1B(10), CACNA1C(15), CACNA1D(6), CACNA1E(19), CACNA1F(10), CACNA1G(7), CACNA1H(5), CACNA1I(11), CACNA1S(6), CACNA2D1(10), CACNA2D2(3), CACNA2D3(3), CACNA2D4(9), CACNB2(5), CACNB3(2), CACNB4(1), CACNG2(1), CACNG3(4), CACNG4(2), CACNG6(1), CACNG7(4), CACNG8(1), CD14(2), CDC25B(2), CDC42(1), CHP(2), CHUK(2), CRKL(1), DAXX(3), DUSP10(4), DUSP16(2), DUSP4(2), DUSP5(5), DUSP6(2), DUSP7(1), DUSP8(1), DUSP9(2), EGF(6), EGFR(7), ELK4(1), FAS(1), FASLG(1), FGF10(2), FGF12(3), FGF14(2), FGF18(1), FGF2(2), FGF22(1), FGF23(2), FGF3(1), FGF5(2), FGF6(2), FGF8(1), FGFR1(1), FGFR2(4), FGFR3(4), FGFR4(2), FLNA(14), FLNB(3), FLNC(16), FOS(2), GADD45A(1), GADD45B(1), GADD45G(1), GNA12(2), GNG12(1), HRAS(4), IKBKB(2), IL1A(1), IL1B(1), IL1R1(1), IL1R2(3), JUN(3), JUND(2), KRAS(2), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K5(1), MAP2K6(2), MAP2K7(1), MAP3K1(3), MAP3K12(4), MAP3K13(5), MAP3K14(1), MAP3K3(1), MAP3K4(4), MAP3K5(4), MAP3K6(1), MAP3K7(2), MAP4K1(3), MAP4K2(1), MAP4K3(7), MAP4K4(7), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), MAPKAPK2(2), MAPKAPK3(1), MAPKAPK5(3), MAPT(4), MEF2C(4), MKNK2(1), MOS(4), MRAS(2), MYC(1), NF1(22), NFATC2(4), NFATC4(2), NFKB1(2), NFKB2(2), NLK(2), NR4A1(4), NRAS(1), NTF3(3), NTRK1(4), NTRK2(1), PAK1(2), PAK2(1), PDGFB(1), PDGFRA(10), PDGFRB(6), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PPM1A(2), PPM1B(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), PTPN5(1), PTPN7(1), PTPRR(9), RAC1(1), RAF1(1), RAP1A(1), RAP1B(1), RAPGEF2(6), RASA1(8), RASA2(3), RASGRF1(7), RASGRF2(6), RASGRP1(1), RASGRP2(1), RASGRP3(7), RASGRP4(5), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KA4(1), RPS6KA5(4), RPS6KA6(5), RRAS2(2), SOS1(11), SOS2(7), SRF(2), STK3(2), STK4(2), TAOK1(7), TAOK2(5), TAOK3(4), TGFB1(1), TGFB2(3), TGFBR2(3), TNF(1), TNFRSF1A(2), TP53(144), TRAF6(5) 77088774 810 174 755 217 196 279 58 140 137 0 0.0063 1.00 1.00 266 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(1), ACTG1(2), ACTN1(2), ACTN2(9), ACTN3(2), ACTN4(5), AKT1(1), AKT3(3), ARHGAP5(2), BCAR1(6), BIRC2(1), BIRC3(3), BRAF(8), CAPN2(2), CAV2(1), CAV3(1), CCND1(1), CCND2(3), CCND3(1), CDC42(1), COL11A1(45), COL11A2(13), COL1A1(11), COL1A2(14), COL2A1(12), COL3A1(16), COL4A1(9), COL4A2(10), COL4A4(11), COL4A6(8), COL5A1(7), COL5A2(14), COL5A3(12), COL6A2(6), COL6A3(13), COL6A6(20), COMP(1), CRKL(1), CTNNB1(4), DIAPH1(1), DOCK1(4), EGF(6), EGFR(7), ERBB2(2), FARP2(7), FIGF(2), FLNA(14), FLNB(3), FLNC(16), FLT1(11), FN1(21), FYN(5), GRLF1(13), HGF(10), HRAS(4), IBSP(6), IGF1(3), IGF1R(1), ILK(1), ITGA1(4), ITGA10(8), ITGA11(6), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(13), ITGA9(2), ITGAV(4), ITGB1(5), ITGB3(4), ITGB4(8), ITGB6(1), ITGB7(1), ITGB8(4), JUN(3), KDR(15), LAMA1(15), LAMA2(24), LAMA3(10), LAMA4(16), LAMA5(7), LAMB1(6), LAMB2(4), LAMB3(3), LAMB4(6), LAMC1(8), LAMC2(5), LAMC3(5), MAP2K1(2), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MET(4), MYL2(2), MYL9(1), MYLK(8), MYLK2(3), MYLPF(1), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK7(6), PARVB(1), PARVG(2), PDGFB(1), PDGFC(2), PDGFD(1), PDGFRA(10), PDGFRB(6), PDPK1(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(17), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIP5K1C(2), PRKCA(5), PRKCG(9), PTEN(16), PTK2(6), PXN(3), RAC1(1), RAF1(1), RAP1A(1), RAP1B(1), RAPGEF1(4), RELN(33), ROCK1(5), ROCK2(3), SHC1(2), SHC2(4), SHC3(2), SHC4(5), SOS1(11), SOS2(7), SPP1(1), THBS1(1), THBS2(16), THBS3(3), THBS4(1), TLN1(6), TLN2(14), TNC(14), TNN(20), TNR(26), TNXB(19), VASP(2), VAV1(7), VAV2(4), VAV3(1), VCL(2), VEGFC(6), VWF(17), ZYX(1) 99738206 1039 173 1022 295 300 388 67 161 123 0 0.082 1.00 1.00 267 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(9), ADORA1(3), ADORA2A(5), ADORA3(1), ADRA1A(2), ADRA1B(3), ADRA2B(6), ADRA2C(2), ADRB1(1), ADRB2(4), AGTR1(5), AGTR2(3), AVPR1A(3), AVPR1B(2), AVPR2(4), BDKRB1(2), BDKRB2(3), C3AR1(2), C5AR1(3), CALCR(10), CALCRL(3), CCKAR(2), CCKBR(2), CGA(2), CHRM2(8), CHRM3(5), CHRM4(1), CHRM5(3), CNR1(5), CNR2(2), CRHR1(3), CRHR2(3), CTSG(3), CYSLTR1(2), CYSLTR2(1), DRD1(1), DRD2(4), DRD3(5), DRD4(1), DRD5(5), EDNRA(1), EDNRB(5), F2R(2), F2RL1(3), F2RL2(1), F2RL3(1), FPR1(1), FSHB(2), FSHR(15), GABBR1(3), GABBR2(3), GABRA1(7), GABRA2(12), GABRA3(4), GABRA4(4), GABRA5(6), GABRA6(8), GABRB1(4), GABRB2(6), GABRB3(11), GABRD(2), GABRE(4), GABRG1(15), GABRG2(4), GABRG3(10), GABRP(2), GABRQ(5), GABRR1(4), GABRR2(4), GALR1(5), GH1(2), GH2(5), GHR(3), GHRHR(4), GHSR(4), GLP1R(1), GLP2R(5), GLRA1(2), GLRA2(5), GLRA3(3), GLRB(3), GPR156(4), GPR35(1), GPR50(5), GPR63(4), GPR83(2), GRIA1(9), GRIA2(7), GRIA3(11), GRIA4(10), GRID1(13), GRID2(15), GRIK1(5), GRIK2(9), GRIK3(10), GRIK4(4), GRIK5(2), GRIN1(1), GRIN2A(16), GRIN2B(18), GRIN2C(3), GRIN2D(3), GRIN3A(8), GRIN3B(4), GRM1(12), GRM2(2), GRM3(14), GRM4(3), GRM5(12), GRM6(6), GRM7(10), GRM8(13), GRPR(3), GZMA(4), HCRTR2(3), HRH1(3), HRH2(1), HRH3(1), HRH4(4), HTR1A(7), HTR1B(3), HTR1E(5), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(4), HTR4(3), HTR5A(4), HTR6(1), HTR7(3), LEPR(15), LHB(1), LHCGR(9), LTB4R2(1), MAS1(3), MC2R(2), MC3R(2), MC4R(2), MC5R(3), MCHR1(2), MCHR2(6), MLNR(2), MTNR1A(1), MTNR1B(10), NMBR(3), NMUR2(1), NPBWR1(4), NPBWR2(3), NPFFR2(8), NPY1R(3), NPY2R(4), NPY5R(4), NR3C1(1), NTSR1(4), NTSR2(3), OPRD1(2), OPRK1(1), OPRL1(2), OPRM1(6), OXTR(1), P2RX2(4), P2RX3(5), P2RX4(1), P2RX7(2), P2RY1(3), P2RY10(5), P2RY13(1), P2RY14(3), P2RY2(3), P2RY4(2), P2RY6(2), P2RY8(2), PARD3(8), PPYR1(4), PRL(1), PRLHR(2), PRLR(6), PRSS1(4), PRSS3(2), PTAFR(3), PTGDR(5), PTGER2(2), PTGER3(5), PTGER4(2), PTGFR(5), PTGIR(1), PTH2R(5), RXFP1(8), RXFP2(2), SCTR(1), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(2), SSTR5(1), TAAR1(5), TAAR2(4), TAAR5(5), TAAR6(5), TAAR8(3), TAAR9(3), TACR1(3), TACR2(1), TACR3(4), TBXA2R(2), THRA(1), THRB(2), TRHR(2), TRPV1(3), TSHR(5), VIPR2(3) 59245876 885 170 882 300 200 358 78 154 95 0 0.062 1.00 1.00 268 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(9), APC2(2), AXIN2(2), BTRC(1), CACYBP(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CCND1(1), CCND2(3), CCND3(1), CER1(2), CHD8(9), CHP(2), CREBBP(17), CSNK1A1(2), CSNK1A1L(5), CSNK2A1(3), CTBP1(2), CTNNB1(4), CUL1(4), CXXC4(1), DAAM1(1), DAAM2(7), DKK1(4), DKK2(1), DVL1(3), DVL3(2), EP300(9), FBXW11(1), FOSL1(1), FZD1(1), FZD10(2), FZD2(1), FZD3(5), FZD4(1), FZD6(3), FZD7(2), FZD8(1), FZD9(2), JUN(3), LEF1(3), LRP5(6), LRP6(5), MAP3K7(2), MAPK10(1), MAPK8(2), MAPK9(1), MYC(1), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NKD1(2), NKD2(2), NLK(2), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PORCN(2), PPARD(2), PPP2R1A(8), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRICKLE1(7), PRICKLE2(3), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), PSEN1(3), RAC1(1), RBX1(1), ROCK1(5), ROCK2(3), RUVBL1(4), SENP2(3), SFRP1(1), SFRP4(4), SFRP5(1), SIAH1(1), SKP1(1), SMAD2(2), SMAD3(1), SMAD4(5), TBL1XR1(2), TBL1Y(2), TCF7(1), TCF7L2(1), TP53(144), VANGL1(1), VANGL2(2), WIF1(5), WNT1(1), WNT10A(1), WNT10B(4), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(2), WNT5A(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT9A(1), WNT9B(1) 43421676 478 170 428 121 96 177 43 77 85 0 0.032 1.00 1.00 269 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(10), ADCY2(17), ADCY3(7), ADCY4(4), ADCY7(7), ADCY8(18), ADCY9(3), ADORA2A(5), ADRA1A(2), ADRA1B(3), ADRA1D(3), ADRB1(1), ADRB2(4), AGTR1(5), ATP2A1(1), ATP2A2(3), ATP2A3(3), ATP2B1(4), ATP2B2(7), ATP2B3(2), ATP2B4(3), AVPR1A(3), AVPR1B(2), BDKRB1(2), BDKRB2(3), BST1(1), CACNA1A(10), CACNA1B(10), CACNA1C(15), CACNA1D(6), CACNA1E(19), CACNA1F(10), CACNA1G(7), CACNA1H(5), CACNA1I(11), CACNA1S(6), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CCKAR(2), CCKBR(2), CD38(2), CHP(2), CHRM2(8), CHRM3(5), CHRM5(3), CHRNA7(1), CYSLTR1(2), CYSLTR2(1), DRD1(1), EDNRA(1), EDNRB(5), EGFR(7), ERBB2(2), ERBB3(4), ERBB4(13), F2R(2), GNA11(1), GNA14(3), GNA15(1), GNAL(1), GNAS(6), GRIN1(1), GRIN2A(16), GRIN2C(3), GRIN2D(3), GRM1(12), GRM5(12), GRPR(3), HRH1(3), HRH2(1), HTR2A(3), HTR2B(1), HTR2C(4), HTR4(3), HTR5A(4), HTR6(1), HTR7(3), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(13), ITPR3(4), LHCGR(9), LTB4R2(1), MYLK(8), MYLK2(3), NOS1(11), NOS3(2), NTSR1(4), OXTR(1), P2RX2(4), P2RX3(5), P2RX4(1), P2RX7(2), PDE1A(2), PDE1B(3), PDE1C(12), PDGFRA(10), PDGFRB(6), PHKA1(6), PHKA2(4), PHKB(6), PHKG1(2), PHKG2(1), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCD3(1), PLCE1(13), PLCG1(3), PLCG2(4), PLCZ1(5), PLN(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), PTAFR(3), PTGER3(5), PTGFR(5), RYR1(27), RYR2(112), RYR3(50), SLC25A5(1), SLC25A6(1), SLC8A1(15), SLC8A2(2), SLC8A3(3), SPHK2(1), TACR1(3), TACR2(1), TACR3(4), TBXA2R(2), TNNC1(1), TRHR(2), TRPC1(6), VDAC1(1) 72590536 843 169 838 257 195 350 56 149 91 2 0.011 1.00 1.00 270 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(1), ACTG1(2), COL11A1(45), COL11A2(13), COL17A1(4), COL1A1(11), COL1A2(14), COL2A1(12), COL3A1(16), COL4A1(9), COL4A2(10), COL4A4(11), COL4A6(8), COL5A1(7), COL5A2(14), COL5A3(12), COL6A2(6), COL6A3(13), COL6A6(20), COMP(1), DES(3), DSC1(8), DSC2(1), DSC3(6), DSG1(9), DSG2(3), DSG3(4), DSG4(8), FN1(21), GJA1(4), GJA10(7), GJA4(1), GJA5(1), GJA8(4), GJA9(4), GJB2(1), GJB4(3), GJC1(2), GJC2(1), GJC3(1), GJD2(2), GJD4(2), IBSP(6), INA(2), ITGA6(7), ITGB4(8), KRT1(1), KRT10(1), KRT12(3), KRT13(4), KRT14(3), KRT15(1), KRT16(3), KRT17(2), KRT18(2), KRT2(5), KRT20(2), KRT23(4), KRT24(3), KRT27(2), KRT28(2), KRT3(2), KRT31(2), KRT32(2), KRT33A(1), KRT35(1), KRT36(2), KRT37(2), KRT39(1), KRT4(2), KRT40(2), KRT5(1), KRT6A(2), KRT6B(3), KRT6C(1), KRT71(3), KRT72(4), KRT73(6), KRT74(2), KRT75(1), KRT76(3), KRT77(4), KRT79(3), KRT8(1), KRT81(3), KRT82(2), KRT83(2), KRT84(4), KRT85(2), KRT86(1), KRT9(2), LAMA1(15), LAMA2(24), LAMA3(10), LAMA4(16), LAMA5(7), LAMB1(6), LAMB2(4), LAMB3(3), LAMB4(6), LAMC1(8), LAMC2(5), LAMC3(5), LMNA(1), NES(13), PRPH(3), RELN(33), SPP1(1), THBS1(1), THBS2(16), THBS3(3), THBS4(1), TNC(14), TNN(20), TNR(26), TNXB(19), VIM(6), VWF(17) 66711552 736 168 735 218 203 289 57 107 80 0 0.18 1.00 1.00 271 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(3), ANAPC1(6), ANAPC4(3), ANAPC5(5), ATM(8), ATR(13), BUB1(4), BUB1B(6), BUB3(2), CCNA1(1), CCNA2(1), CCNB1(2), CCNB2(1), CCNB3(11), CCND1(1), CCND2(3), CCND3(1), CCNE1(3), CCNE2(2), CDC14A(1), CDC14B(2), CDC16(1), CDC20(1), CDC23(1), CDC25B(2), CDC25C(1), CDC27(3), CDC6(6), CDC7(3), CDK7(1), CDKN1A(2), CDKN2A(26), CDKN2B(1), CDKN2C(1), CHEK1(5), CHEK2(3), CREBBP(17), CUL1(4), DBF4(4), E2F1(2), EP300(9), ESPL1(5), GADD45A(1), GADD45B(1), GADD45G(1), HDAC1(2), MAD1L1(6), MAD2L1(2), MCM2(1), MCM3(1), MCM4(5), MCM5(6), MCM6(3), MCM7(3), MDM2(2), ORC1L(3), ORC2L(1), ORC3L(2), ORC5L(3), PKMYT1(1), PLK1(2), PRKDC(12), PTTG1(2), PTTG2(2), RB1(12), RBL1(5), RBL2(7), RBX1(1), SFN(2), SKP1(1), SKP2(2), SMAD2(2), SMAD3(1), SMAD4(5), SMC1A(2), SMC1B(9), TFDP1(3), TGFB1(1), TGFB2(3), TP53(144), WEE1(4), YWHAB(1), YWHAQ(1) 36723180 445 166 393 67 105 125 37 77 101 0 1.34e-06 1.00 1.00 272 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(1), AKT1(1), AKT3(3), APAF1(4), ATM(8), BAX(1), BCL2L1(1), BIRC2(1), BIRC3(3), CAPN1(2), CAPN2(2), CASP10(3), CASP7(2), CASP8(2), CASP9(3), CFLAR(1), CHP(2), CHUK(2), CSF2RB(5), DFFB(2), FADD(1), FAS(1), FASLG(1), IKBKB(2), IL1A(1), IL1B(1), IL1R1(1), IL1RAP(2), IL3(1), IRAK1(3), IRAK2(1), IRAK3(4), MAP3K14(1), NFKB1(2), NFKB2(2), NTRK1(4), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(17), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), RELA(3), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF1A(2), TP53(144), TRADD(1) 22508634 319 165 257 61 73 89 26 59 72 0 0.0010 1.00 1.00 273 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTB(1), ACTG1(2), ACTN1(2), ACTN2(9), ACTN3(2), ACTN4(5), AKT1(1), AKT3(3), AMOTL1(3), ASH1L(9), CASK(2), CDC42(1), CGN(5), CLDN1(2), CLDN10(4), CLDN11(1), CLDN15(1), CLDN16(4), CLDN17(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(2), CLDN8(1), CLDN9(3), CSDA(5), CSNK2A1(3), CTNNA1(1), CTNNA2(27), CTNNA3(16), CTNNB1(4), CTTN(5), EPB41(3), EPB41L1(2), EPB41L2(3), EPB41L3(20), EXOC3(3), EXOC4(3), F11R(1), GNAI1(3), GNAI3(1), HCLS1(3), HRAS(4), IGSF5(2), INADL(13), JAM2(2), KRAS(2), LLGL1(1), LLGL2(3), MAGI1(7), MAGI2(12), MAGI3(2), MLLT4(4), MPDZ(6), MPP5(4), MRAS(2), MYH1(23), MYH10(1), MYH11(8), MYH13(11), MYH14(6), MYH15(17), MYH2(31), MYH3(6), MYH4(21), MYH6(14), MYH7(13), MYH7B(8), MYH8(24), MYH9(13), MYL2(2), MYL9(1), MYLPF(1), NRAS(1), PARD3(8), PARD6A(1), PARD6G(1), PPM1J(1), PPP2R1A(8), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PPP2R3A(3), PPP2R4(1), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCI(5), PRKCQ(4), PRKCZ(1), PTEN(16), RAB3B(2), RRAS2(2), SPTAN1(4), SYMPK(8), TJAP1(4), TJP1(9), TJP2(3), TJP3(2), VAPA(1), YES1(1) 52015160 549 165 547 146 161 185 40 89 74 0 0.054 1.00 1.00 274 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(3), ATM(8), BUB1(4), BUB1B(6), BUB3(2), CCNA1(1), CCNA2(1), CCNB1(2), CCNB2(1), CCNB3(11), CCND2(3), CCND3(1), CCNE1(3), CCNE2(2), CDAN1(3), CDC14A(1), CDC14B(2), CDC20(1), CDC25B(2), CDC25C(1), CDC6(6), CDC7(3), CDH1(3), CDKN1A(2), CDKN2A(26), CHEK1(5), CHEK2(3), DTX4(2), E2F1(2), E2F5(2), EP300(9), ESPL1(5), GADD45A(1), HDAC1(2), HDAC3(1), HDAC4(5), HDAC5(1), HDAC8(1), MAD1L1(6), MAD2L1(2), MCM2(1), MCM3(1), MCM4(5), MCM5(6), MCM6(3), MCM7(3), MDM2(2), MPEG1(6), MPL(2), ORC1L(3), ORC2L(1), ORC3L(2), ORC5L(3), PLK1(2), PRKDC(12), PTTG1(2), PTTG2(2), RB1(12), RBL1(5), SKP2(2), SMAD4(5), TBC1D8(1), TFDP1(3), TGFB1(1), TP53(144), WEE1(4) 29714786 378 163 326 53 75 109 33 66 95 0 2.06e-07 1.00 1.00 275 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(10), ADCY2(17), ADCY3(7), ADCY4(4), ADCY5(1), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ADRA1A(2), ADRA1B(3), ADRA1D(3), ADRB1(1), ADRB2(4), ANXA6(4), ARRB1(2), ATP1A4(6), ATP1B2(1), ATP1B3(1), ATP2A2(3), ATP2A3(3), ATP2B1(4), ATP2B2(7), ATP2B3(2), CACNA1A(10), CACNA1B(10), CACNA1C(15), CACNA1D(6), CACNA1E(19), CACNA1S(6), CACNB3(2), CALM2(1), CALR(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CASQ1(1), CASQ2(3), CHRM2(8), CHRM3(5), CHRM4(1), CHRM5(3), GJA1(4), GJA4(1), GJA5(1), GJB2(1), GJB4(3), GNA11(1), GNAI3(1), GNAZ(3), GNB1(1), GNB2(2), GNB3(2), GNB4(3), GNB5(1), GNG12(1), GNG4(2), GNG5(1), GRK4(1), GRK5(1), GRK6(1), ITPR1(6), ITPR2(13), ITPR3(4), KCNB1(1), KCNJ3(11), KCNJ5(2), MIB1(2), NME7(3), PEA15(1), PKIB(1), PLCB3(4), PLN(1), PRKACB(3), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCQ(4), PRKCZ(1), PRKD1(11), RGS1(3), RGS10(1), RGS11(1), RGS16(1), RGS17(2), RGS18(1), RGS19(1), RGS20(1), RGS3(5), RGS5(2), RGS6(5), RGS7(13), RGS9(2), RYR1(27), RYR2(112), RYR3(50), SFN(2), SLC8A1(15), SLC8A3(3), USP5(2), YWHAB(1), YWHAQ(1) 50784646 588 161 584 179 136 234 41 113 62 2 0.054 1.00 1.00 276 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(3), CD36(1), CD44(5), CD47(2), COL11A1(45), COL11A2(13), COL1A1(11), COL1A2(14), COL2A1(12), COL3A1(16), COL4A1(9), COL4A2(10), COL4A4(11), COL4A6(8), COL5A1(7), COL5A2(14), COL5A3(12), COL6A2(6), COL6A3(13), COL6A6(20), DAG1(2), FN1(21), FNDC1(8), FNDC3A(1), GP5(4), GP6(2), GP9(2), HMMR(2), HSPG2(11), IBSP(6), ITGA1(4), ITGA10(8), ITGA11(6), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(13), ITGA9(2), ITGAV(4), ITGB1(5), ITGB3(4), ITGB4(8), ITGB6(1), ITGB7(1), ITGB8(4), LAMA1(15), LAMA2(24), LAMA3(10), LAMA4(16), LAMA5(7), LAMB1(6), LAMB2(4), LAMB3(3), LAMB4(6), LAMC1(8), LAMC2(5), LAMC3(5), RELN(33), SDC1(1), SDC2(2), SDC3(2), SPP1(1), SV2A(3), SV2B(4), SV2C(4), THBS1(1), THBS2(16), THBS3(3), THBS4(1), TNC(14), TNN(20), TNR(26), TNXB(19), VWF(17) 60504692 652 160 651 189 177 258 43 101 73 0 0.20 1.00 1.00 277 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(3), BAK1(1), BAX(1), BTK(7), CAD(10), CASP10(3), CASP8(2), CASP8AP2(6), CD7(1), CDK2AP1(1), CSNK1A1(2), DAXX(3), EGFR(7), EPHB2(5), FADD(1), FAF1(1), FAIM2(1), IL1A(1), MAP2K4(1), MAP2K7(1), MAP3K1(3), MAP3K5(4), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), MET(4), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(4), NR0B2(1), PFN2(1), PTPN13(9), RALBP1(1), ROCK1(5), SMPD1(4), TNFRSF6B(1), TP53(144), TPX2(1), TUFM(1) 19699082 262 159 213 41 40 78 26 55 63 0 0.00015 1.00 1.00 278 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(3), ADCY1(10), ADCY2(17), ADCY3(7), ADCY4(4), ADCY5(1), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ARRB1(2), ATF2(3), ATF3(1), ATF4(2), ATP2A2(3), ATP2A3(3), CACNB3(2), CALM2(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CNN1(2), CORIN(11), CREB3(2), CRHR1(3), DGKZ(4), FOS(2), GABPA(2), GABPB2(2), GJA1(4), GNB1(1), GNB2(2), GNB3(2), GNB4(3), GNB5(1), GNG12(1), GNG4(2), GNG5(1), GRK4(1), GRK5(1), GRK6(1), GSTO1(1), GUCY1A3(7), IGFBP3(2), IGFBP6(2), IL1B(1), IL6(1), ITPR1(6), ITPR2(13), ITPR3(4), JUN(3), MIB1(2), MYL2(2), MYL4(1), MYLK2(3), NFKB1(2), NOS1(11), NOS3(2), OXTR(1), PDE4B(3), PDE4D(2), PKIB(1), PLCB3(4), PLCD1(1), PLCG1(3), PLCG2(4), PRKACB(3), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), PRKCA(5), PRKCD(2), PRKCE(3), PRKCQ(4), PRKCZ(1), PRKD1(11), RAMP2(1), RGS1(3), RGS10(1), RGS11(1), RGS16(1), RGS17(2), RGS18(1), RGS19(1), RGS20(1), RGS3(5), RGS5(2), RGS6(5), RGS7(13), RGS9(2), RYR1(27), RYR2(112), RYR3(50), SFN(2), SLC8A1(15), SP1(2), TNXB(19), USP5(2), YWHAB(1), YWHAQ(1) 46797802 528 157 522 155 136 197 40 98 55 2 0.063 1.00 1.00 279 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(3), ABLIM1(2), ABLIM2(2), ABLIM3(3), ARHGEF12(5), CDC42(1), CDK5(1), CFL1(2), CFL2(1), CHP(2), CXCR4(5), DCC(14), DPYSL2(1), DPYSL5(8), EFNA3(1), EFNB1(3), EFNB2(2), EPHA1(3), EPHA2(2), EPHA3(11), EPHA4(1), EPHA5(15), EPHA6(14), EPHA7(9), EPHA8(6), EPHB1(13), EPHB2(5), EPHB3(8), EPHB4(3), EPHB6(4), FYN(5), GNAI1(3), GNAI3(1), HRAS(4), ITGB1(5), KRAS(2), L1CAM(2), LIMK2(2), LRRC4C(19), MAPK1(1), MAPK3(1), MET(4), NCK1(2), NCK2(1), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NGEF(1), NRAS(1), NRP1(5), NTN1(3), NTN4(2), NTNG1(1), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK7(6), PLXNA1(11), PLXNA2(2), PLXNA3(5), PLXNB1(3), PLXNB2(4), PLXNB3(4), PLXNC1(9), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PTK2(6), RAC1(1), RASA1(8), RGS3(5), ROBO1(9), ROBO2(9), ROBO3(7), ROCK1(5), ROCK2(3), SEMA3A(4), SEMA3B(1), SEMA3C(5), SEMA3D(3), SEMA3E(5), SEMA3F(3), SEMA3G(3), SEMA4A(1), SEMA4B(1), SEMA4C(2), SEMA4D(1), SEMA4F(6), SEMA5A(9), SEMA5B(6), SEMA6B(1), SEMA6C(5), SEMA6D(8), SEMA7A(1), SLIT1(5), SLIT2(15), SLIT3(9), SRGAP1(6), SRGAP2(5), SRGAP3(5), UNC5A(5), UNC5B(2), UNC5C(7), UNC5D(19) 53021216 493 156 493 183 112 189 33 90 69 0 0.90 1.00 1.00 280 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ACTN1(2), ACTN2(9), ACTN3(2), ACTN4(5), APC(9), APC2(2), ARAF(3), ARHGEF1(2), ARHGEF12(5), ARHGEF4(3), ARHGEF6(2), ARHGEF7(3), ARPC1A(4), BAIAP2(2), BCAR1(6), BDKRB1(2), BDKRB2(3), BRAF(8), CD14(2), CDC42(1), CFL1(2), CFL2(1), CHRM2(8), CHRM3(5), CHRM4(1), CHRM5(3), CRKL(1), CYFIP1(5), CYFIP2(6), DIAPH1(1), DIAPH2(4), DIAPH3(5), DOCK1(4), EGF(6), EGFR(7), F2R(2), FGD1(3), FGD3(2), FGF10(2), FGF12(3), FGF14(2), FGF18(1), FGF2(2), FGF22(1), FGF23(2), FGF3(1), FGF5(2), FGF6(2), FGF8(1), FGFR1(1), FGFR2(4), FGFR3(4), FGFR4(2), FN1(21), GIT1(1), GNA12(2), GNA13(1), GNG12(1), GRLF1(13), GSN(2), HRAS(4), IQGAP1(8), IQGAP2(6), IQGAP3(11), ITGA1(4), ITGA10(8), ITGA11(6), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(13), ITGA9(2), ITGAD(8), ITGAE(4), ITGAL(1), ITGAM(7), ITGAV(4), ITGAX(9), ITGB1(5), ITGB2(5), ITGB3(4), ITGB4(8), ITGB6(1), ITGB7(1), ITGB8(4), KRAS(2), LIMK2(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MOS(4), MRAS(2), MSN(4), MYH10(1), MYH14(6), MYH9(13), MYL2(2), MYL9(1), MYLK(8), MYLK2(3), MYLPF(1), NCKAP1(7), NCKAP1L(12), NRAS(1), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK7(6), PDGFB(1), PDGFRA(10), PDGFRB(6), PFN2(1), PFN3(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(17), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(4), PIP5K1B(2), PIP5K1C(2), PPP1R12B(5), PTK2(6), PXN(3), RAC1(1), RAF1(1), RDX(2), ROCK1(5), ROCK2(3), RRAS2(2), SCIN(1), SLC9A1(3), SOS1(11), SOS2(7), SSH1(1), SSH2(8), SSH3(1), TIAM1(11), TIAM2(5), VAV1(7), VAV2(4), VAV3(1), VCL(2), WAS(4), WASF1(1), WASL(2) 74443516 641 155 624 184 205 208 28 127 73 0 0.099 1.00 1.00 281 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(3), ADORA2A(5), ADORA3(1), ADRA1A(2), ADRA1B(3), ADRA1D(3), ADRA2C(2), ADRB1(1), ADRB2(4), AGTR1(5), AGTR2(3), AVPR1A(3), AVPR1B(2), AVPR2(4), BDKRB1(2), BDKRB2(3), C3AR1(2), CCBP2(4), CCKAR(2), CCKBR(2), CCR1(3), CCR10(1), CCR2(1), CCR3(1), CCR4(3), CCR5(2), CCR6(2), CCR8(1), CCR9(1), CCRL1(2), CCRL2(1), CHML(2), CHRM2(8), CHRM3(5), CHRM4(1), CHRM5(3), CMKLR1(1), CNR1(5), CNR2(2), CX3CR1(3), CXCR3(1), CXCR4(5), DRD1(1), DRD2(4), DRD3(5), DRD4(1), DRD5(5), EDNRA(1), EDNRB(5), F2R(2), F2RL1(3), F2RL2(1), F2RL3(1), FPR1(1), FSHR(15), GALR1(5), GALT(1), GHSR(4), GPR17(4), GPR173(1), GPR174(6), GPR27(1), GPR35(1), GPR37(3), GPR37L1(2), GPR50(5), GPR6(2), GPR63(4), GPR77(3), GPR83(2), GPR85(2), GPR87(4), GRPR(3), HCRTR2(3), HRH1(3), HRH2(1), HRH3(1), HTR1A(7), HTR1B(3), HTR1E(5), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(4), HTR4(3), HTR5A(4), HTR6(1), HTR7(3), LHCGR(9), MAS1(3), MC3R(2), MC4R(2), MC5R(3), MLNR(2), MTNR1A(1), MTNR1B(10), NMBR(3), NMUR2(1), NPY1R(3), NPY2R(4), NPY5R(4), NTSR1(4), NTSR2(3), OPN1SW(3), OPN3(2), OPRD1(2), OPRK1(1), OPRL1(2), OPRM1(6), OR10A5(2), OR11A1(4), OR12D3(4), OR1C1(9), OR1F1(1), OR1Q1(2), OR2H1(2), OR5V1(3), OR8B8(6), OXTR(1), P2RY1(3), P2RY10(5), P2RY13(1), P2RY14(3), P2RY2(3), P2RY6(2), PPYR1(4), PTAFR(3), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(5), PTGIR(1), RGR(1), RHO(1), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(2), SUCNR1(2), TBXA2R(2), TRHR(2) 32461860 412 153 412 155 83 172 28 85 44 0 0.26 1.00 1.00 282 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(3), ACTN2(9), ACTN3(2), ACTN4(5), DES(3), DMD(34), FAM48A(2), MYBPC1(9), MYBPC3(5), MYH3(6), MYH6(14), MYH7(13), MYH8(24), MYL1(3), MYL2(2), MYL3(2), MYL4(1), MYL9(1), MYOM1(11), NEB(30), TNNI2(2), TNNI3(2), TNNT1(1), TNNT2(2), TNNT3(3), TPM1(1), TPM3(1), TTN(332), VIM(6) 36986086 529 150 527 161 143 194 36 99 54 3 0.83 1.00 1.00 283 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(10), ADCY2(17), ADCY3(7), ADCY4(4), ADCY5(1), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ADSL(1), ADSS(1), ADSSL1(2), AK2(1), AK5(7), AK7(3), ALLC(3), AMPD1(4), AMPD2(1), AMPD3(7), ATIC(1), CANT1(1), DCK(1), ENPP1(8), ENPP3(6), ENTPD1(1), ENTPD2(2), ENTPD3(1), ENTPD5(1), ENTPD6(4), ENTPD8(1), GART(3), GDA(7), GUCY1A2(12), GUCY1A3(7), GUCY1B3(4), GUCY2C(5), GUCY2D(2), GUCY2F(6), GUK1(2), HPRT1(1), IMPDH1(2), IMPDH2(1), NME4(1), NME7(3), NPR1(3), NPR2(4), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5C3(3), NT5E(2), NUDT9(2), PAPSS2(1), PDE10A(9), PDE11A(10), PDE1A(2), PDE1C(12), PDE2A(4), PDE3B(5), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(2), PDE5A(4), PDE6H(2), PDE7A(1), PDE7B(1), PDE8A(5), PDE8B(3), PDE9A(2), PFAS(6), PKLR(4), PKM2(3), PNPT1(2), POLA1(6), POLD1(2), POLD2(1), POLD3(1), POLE(7), POLE2(2), POLE4(1), POLR1A(3), POLR1B(2), POLR1D(1), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLR3A(1), POLR3B(2), POLR3G(1), POLR3H(2), PPAT(2), PRIM1(3), PRIM2(15), PRPS1(2), PRPS1L1(3), PRPS2(1), RFC5(1), RRM1(1), RRM2(1), RRM2B(3), XDH(10) 43946598 374 142 373 127 99 141 20 57 57 0 0.68 1.00 1.00 284 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(10), ADCY2(17), ADCY3(7), ADCY4(4), ADCY5(1), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ADRB1(1), CSNK1D(2), DRD1(1), DRD2(4), EGF(6), EGFR(7), GJA1(4), GJD2(2), GNA11(1), GNAI1(3), GNAI3(1), GNAS(6), GRM1(12), GRM5(12), GUCY1A2(12), GUCY1A3(7), GUCY1B3(4), GUCY2C(5), GUCY2D(2), GUCY2F(6), HRAS(4), HTR2A(3), HTR2B(1), HTR2C(4), ITPR1(6), ITPR2(13), ITPR3(4), KRAS(2), MAP2K1(2), MAP2K2(1), MAP2K5(1), MAPK1(1), MAPK3(1), MAPK7(1), NPR1(3), NPR2(4), NRAS(1), PDGFB(1), PDGFC(2), PDGFD(1), PDGFRA(10), PDGFRB(6), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKG1(6), PRKG2(4), PRKX(1), RAF1(1), SOS1(11), SOS2(7), TJP1(9), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(7), TUBA3D(2), TUBA3E(5), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(1), TUBB2A(2), TUBB3(2), TUBB4(4), TUBB4Q(2), TUBB8(1) 35433748 356 141 354 97 87 126 29 71 43 0 0.050 1.00 1.00 285 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(1), AKT3(3), BCL2L1(1), CBL(3), CBLB(7), CCND1(1), CCND2(3), CCND3(1), CNTFR(1), CREBBP(17), CSF2RA(7), CSF2RB(5), CSF3R(7), EP300(9), EPOR(2), GH1(2), GH2(5), GHR(3), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNG(1), IFNGR1(4), IFNGR2(1), IL10(2), IL10RA(2), IL11RA(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL13RA1(2), IL13RA2(1), IL19(1), IL20RA(1), IL21(1), IL21R(3), IL22(2), IL22RA2(1), IL23R(2), IL28B(2), IL28RA(1), IL2RB(2), IL2RG(1), IL3(1), IL4(2), IL4R(2), IL5RA(3), IL6(1), IL6R(1), IL6ST(1), IL7(1), IL7R(8), IL9R(6), JAK1(2), JAK2(4), JAK3(7), LEPR(15), LIFR(3), MPL(2), MYC(1), OSMR(5), PIAS1(5), PIAS2(2), PIAS3(3), PIAS4(2), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(17), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIM1(2), PRL(1), PRLR(6), PTPN11(3), SOCS2(2), SOCS3(1), SOCS4(2), SOCS5(3), SOS1(11), SOS2(7), SPRED1(3), SPRED2(1), SPRY2(1), SPRY3(4), STAM(3), STAM2(2), STAT1(2), STAT2(1), STAT3(2), STAT4(5), STAT5A(2), STAT6(2), TPO(10), TYK2(8) 38859892 363 141 347 112 119 107 26 68 43 0 0.54 1.00 1.00 286 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1B(3), ACVR2A(4), AMHR2(7), BMPR1A(3), BMPR1B(1), BMPR2(1), CCL14(2), CCL16(1), CCL20(1), CCL26(2), CCL28(1), CCL3(2), CCL7(1), CCR1(3), CCR2(1), CCR3(1), CCR4(3), CCR5(2), CCR6(2), CCR8(1), CCR9(1), CD27(1), CD40(2), CD40LG(3), CNTFR(1), CSF1(2), CSF1R(3), CSF2RA(7), CSF2RB(5), CSF3R(7), CX3CR1(3), CXCL14(1), CXCL5(2), CXCR3(1), CXCR4(5), EDA2R(1), EDAR(2), EGF(6), EGFR(7), EPOR(2), FAS(1), FASLG(1), FLT1(11), FLT3(7), FLT4(5), GDF5(4), GH1(2), GH2(5), GHR(3), HGF(10), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNG(1), IFNGR1(4), IFNGR2(1), IL10(2), IL10RA(2), IL11RA(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL13RA1(2), IL17A(1), IL17RA(6), IL18R1(2), IL18RAP(4), IL19(1), IL1A(1), IL1B(1), IL1R1(1), IL1R2(3), IL1RAP(2), IL20RA(1), IL21(1), IL21R(3), IL22(2), IL22RA2(1), IL23R(2), IL28B(2), IL28RA(1), IL2RB(2), IL2RG(1), IL3(1), IL4(2), IL4R(2), IL5RA(3), IL6(1), IL6R(1), IL6ST(1), IL7(1), IL7R(8), IL9R(6), INHBA(5), INHBB(1), INHBC(1), KDR(15), KIT(7), LEPR(15), LIFR(3), LTA(2), LTBR(1), MET(4), MPL(2), NGFR(1), OSMR(5), PDGFB(1), PDGFC(2), PDGFRA(10), PDGFRB(6), PF4(1), PLEKHO2(5), PRL(1), PRLR(6), TGFB1(1), TGFB2(3), TGFBR2(3), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11A(2), TNFRSF11B(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF18(1), TNFRSF19(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TNFRSF6B(1), TNFRSF8(1), TNFRSF9(1), TNFSF11(1), TNFSF13(1), TNFSF14(1), TNFSF15(1), TNFSF18(1), TPO(10), VEGFC(6), XCL1(1), XCR1(2) 47548606 403 139 400 157 97 147 24 83 52 0 0.98 1.00 1.00 287 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 ALCAM(3), CADM1(2), CADM3(4), CD2(1), CD22(6), CD226(5), CD276(2), CD34(2), CD4(1), CD40(2), CD40LG(3), CD58(1), CD6(2), CD80(3), CD86(3), CD8A(2), CD8B(1), CD99(2), CDH1(3), CDH15(2), CDH2(10), CDH3(1), CDH4(6), CDH5(2), CLDN1(2), CLDN10(4), CLDN11(1), CLDN15(1), CLDN16(4), CLDN17(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(2), CLDN8(1), CLDN9(3), CNTN1(12), CNTN2(1), CNTNAP1(4), CNTNAP2(30), CTLA4(1), ESAM(4), F11R(1), GLG1(3), HLA-A(7), HLA-B(1), HLA-C(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), HLA-G(2), ICAM1(2), ICAM3(2), ICOS(2), ITGA4(4), ITGA6(7), ITGA8(13), ITGA9(2), ITGAL(1), ITGAM(7), ITGAV(4), ITGB1(5), ITGB2(5), ITGB7(1), ITGB8(4), JAM2(2), L1CAM(2), MADCAM1(1), MAG(4), NCAM1(4), NCAM2(13), NEGR1(2), NEO1(8), NFASC(7), NLGN1(14), NLGN2(1), NLGN3(4), NRCAM(6), NRXN1(22), NRXN2(10), NRXN3(10), PDCD1(2), PTPRC(7), PTPRF(6), PTPRM(6), PVR(1), PVRL1(3), PVRL3(3), SDC1(1), SDC2(2), SDC3(2), SELE(4), SELL(2), SELP(11), SELPLG(1), SIGLEC1(9), VCAM1(5), VCAN(23) 39594142 431 138 430 165 135 147 32 77 39 1 0.94 1.00 1.00 288 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(2), ACACB(9), AKT1(1), AKT3(3), ARAF(3), BRAF(8), CALM2(1), CALML6(1), CBL(3), CBLB(7), CRKL(1), EXOC7(1), FASN(2), FBP2(1), FLOT1(1), FLOT2(1), G6PC(3), G6PC2(3), GCK(5), GYS1(1), GYS2(4), HRAS(4), IKBKB(2), INPP5D(8), INSR(9), IRS1(6), IRS2(2), IRS4(2), KRAS(2), LIPE(1), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MKNK2(1), NRAS(1), PCK1(2), PCK2(1), PDE3A(7), PDE3B(5), PDPK1(1), PFKL(2), PFKM(5), PFKP(2), PHKA1(6), PHKA2(4), PHKB(6), PHKG1(2), PHKG2(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(17), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PKLR(4), PKM2(3), PPARGC1A(6), PPP1R3A(16), PPP1R3C(2), PPP1R3D(2), PRKAA2(5), PRKAB2(1), PRKACB(3), PRKACG(1), PRKAG2(4), PRKAG3(3), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), PRKCI(5), PRKCZ(1), PRKX(1), PTPN1(1), PTPRF(6), PYGB(4), PYGL(3), PYGM(6), RAF1(1), RAPGEF1(4), RPS6(1), RPS6KB1(1), RPS6KB2(1), SH2B2(1), SHC1(2), SHC2(4), SHC3(2), SHC4(5), SLC2A4(2), SOCS2(2), SOCS3(1), SOCS4(2), SORBS1(5), SOS1(11), SOS2(7), SREBF1(2), TRIP10(2), TSC1(5), TSC2(5) 43078670 365 138 352 118 118 121 23 52 51 0 0.48 1.00 1.00 289 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(2), ACTN2(9), ACTN3(2), ACTN4(5), ARHGAP5(2), BCAR1(6), CD99(2), CDC42(1), CDH5(2), CLDN1(2), CLDN10(4), CLDN11(1), CLDN15(1), CLDN16(4), CLDN17(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(2), CLDN8(1), CLDN9(3), CTNNA1(1), CTNNA2(27), CTNNA3(16), CTNNB1(4), CTNND1(4), CXCR4(5), CYBB(6), ESAM(4), F11R(1), GNAI1(3), GNAI3(1), GRLF1(13), ICAM1(2), ITGA4(4), ITGAL(1), ITGAM(7), ITGB1(5), ITGB2(5), ITK(2), JAM2(2), MAPK11(2), MAPK13(2), MAPK14(1), MLLT4(4), MMP2(3), MMP9(6), MSN(4), MYL2(2), MYL9(1), MYLPF(1), NCF2(3), NCF4(1), NOX1(2), NOX3(6), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(17), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(3), PLCG2(4), PRKCA(5), PRKCG(9), PTK2(6), PTPN11(3), PXN(3), RAC1(1), RAP1A(1), RAP1B(1), RAPGEF3(1), RAPGEF4(6), RASSF5(1), RHOH(4), ROCK1(5), ROCK2(3), THY1(2), TXK(3), VASP(2), VAV1(7), VAV2(4), VAV3(1), VCAM1(5), VCL(2) 33311276 354 134 341 105 113 131 21 57 32 0 0.23 1.00 1.00 290 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(10), ADCY8(18), ARAF(3), ATF4(2), BRAF(8), CACNA1C(15), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CHP(2), CREBBP(17), EP300(9), GRIA1(9), GRIA2(7), GRIN1(1), GRIN2A(16), GRIN2B(18), GRIN2C(3), GRIN2D(3), GRM1(12), GRM5(12), HRAS(4), ITPR1(6), ITPR2(13), ITPR3(4), KRAS(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), RAF1(1), RAP1A(1), RAP1B(1), RAPGEF3(1), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KA6(5) 26968424 285 134 282 94 64 110 29 48 34 0 0.54 1.00 1.00 291 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(10), ADCY2(17), ADCY3(7), ADCY4(4), ADCY5(1), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ATF4(2), CACNA1C(15), CACNA1D(6), CACNA1F(10), CACNA1S(6), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CDC42(1), CGA(2), EGFR(7), FSHB(2), GNA11(1), GNAS(6), HBEGF(1), HRAS(4), ITPR1(6), ITPR2(13), ITPR3(4), JUN(3), KRAS(2), LHB(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP2K7(1), MAP3K1(3), MAP3K3(1), MAP3K4(4), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(2), MAPK9(1), MMP14(2), MMP2(3), NRAS(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLD1(7), PLD2(2), PRKACB(3), PRKACG(1), PRKCA(5), PRKCD(2), PRKX(1), RAF1(1), SOS1(11), SOS2(7) 34250226 289 134 286 93 71 113 20 55 30 0 0.42 1.00 1.00 292 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(3), ACTN1(2), AKT1(1), AKT3(3), ARHGEF6(2), ARHGEF7(3), BCAR1(6), BRAF(8), CDC42(1), CDKN2A(26), CSE1L(5), DOCK1(4), EPHB2(5), FYN(5), GRLF1(13), ILK(1), ITGA1(4), ITGA10(8), ITGA11(6), ITGA2(5), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(13), ITGA9(2), ITGB3BP(1), MAP2K4(1), MAP2K7(1), MAP3K11(2), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), MRAS(2), MYLK(8), MYLK2(3), P4HB(4), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK7(6), PIK3CA(29), PIK3CB(4), PKLR(4), PLCG1(3), PLCG2(4), PTEN(16), PTK2(6), RAF1(1), RALA(3), RHO(1), ROCK1(5), ROCK2(3), SHC1(2), SOS1(11), SOS2(7), TLN1(6), TLN2(14), VASP(2), WAS(4), ZYX(1) 32725300 313 132 296 81 106 89 13 57 48 0 0.099 1.00 1.00 293 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(3), BRAF(8), C7orf16(2), CACNA1A(10), CRHR1(3), GNA11(1), GNA12(2), GNA13(1), GNAI1(3), GNAI3(1), GNAS(6), GNAZ(3), GRIA1(9), GRIA2(7), GRIA3(11), GRID2(15), GRM1(12), GRM5(12), GUCY1A2(12), GUCY1A3(7), GUCY1B3(4), GUCY2C(5), GUCY2D(2), GUCY2F(6), HRAS(4), IGF1(3), IGF1R(1), ITPR1(6), ITPR2(13), ITPR3(4), KRAS(2), LYN(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NOS1(11), NOS3(2), NPR1(3), NPR2(4), NRAS(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PPP2R1A(8), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PRKCA(5), PRKCG(9), PRKG1(6), PRKG2(4), RAF1(1), RYR1(27) 29647858 318 131 317 90 81 113 28 52 44 0 0.10 1.00 1.00 294 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(9), ABCA10(9), ABCA12(8), ABCA13(33), ABCA2(9), ABCA3(4), ABCA4(12), ABCA5(5), ABCA6(7), ABCA7(4), ABCA8(6), ABCA9(12), ABCB1(17), ABCB10(5), ABCB11(6), ABCB4(7), ABCB5(14), ABCB6(3), ABCB7(2), ABCB8(1), ABCB9(3), ABCC1(5), ABCC10(9), ABCC11(6), ABCC12(15), ABCC2(6), ABCC3(3), ABCC4(1), ABCC5(8), ABCC6(1), ABCC8(6), ABCC9(10), ABCD1(3), ABCD2(12), ABCD4(1), ABCG1(1), ABCG2(2), ABCG4(4), ABCG5(2), ABCG8(6), CFTR(8), TAP1(3), TAP2(1) 31844200 289 130 287 99 81 91 18 68 30 1 0.54 1.00 1.00 295 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM2(1), CALML6(1), CDS1(2), DGKA(3), DGKB(5), DGKD(6), DGKE(4), DGKG(2), DGKI(13), DGKQ(1), DGKZ(4), FN3K(1), IMPA1(2), INPP1(1), INPP4A(5), INPP4B(6), INPP5A(4), INPP5B(7), INPP5D(8), INPP5E(2), INPPL1(4), ITPK1(3), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(13), ITPR3(4), OCRL(8), PI4KA(7), PI4KB(1), PIK3C2A(6), PIK3C2B(6), PIK3C2G(8), PIK3C3(5), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(17), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(4), PIP5K1B(2), PIP5K1C(2), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCD3(1), PLCE1(13), PLCG1(3), PLCG2(4), PLCZ1(5), PRKCA(5), PRKCG(9), PTEN(16), SYNJ1(4), SYNJ2(3) 33693620 324 130 308 79 104 106 15 51 48 0 0.014 1.00 1.00 296 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(3), BRAF(8), CD244(3), CHP(2), FAS(1), FASLG(1), FCER1G(1), FCGR3A(4), FCGR3B(2), FYN(5), GZMB(1), HLA-A(7), HLA-B(1), HLA-C(1), HLA-G(2), HRAS(4), ICAM1(2), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNG(1), IFNGR1(4), IFNGR2(1), ITGAL(1), ITGB2(5), KIR2DL1(2), KIR2DL3(4), KIR2DL4(1), KIR3DL1(6), KIR3DL2(1), KLRC1(1), KLRC3(2), KLRD1(1), KRAS(2), LCK(3), LCP2(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NCR1(5), NCR2(1), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NRAS(1), PAK1(2), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(17), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(3), PLCG2(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRF1(2), PRKCA(5), PRKCG(9), PTPN11(3), RAC1(1), RAF1(1), SH2D1A(2), SHC1(2), SHC2(4), SHC3(2), SHC4(5), SOS1(11), SOS2(7), SYK(1), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TYROBP(3), ULBP1(2), ULBP3(1), VAV1(7), VAV2(4), VAV3(1), ZAP70(4) 30586274 301 129 287 81 102 105 16 43 34 1 0.074 1.00 1.00 297 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(10), ADCY2(17), ADCY3(7), ADCY4(4), ADCY5(1), ADCY6(2), ADCY7(7), ADCY8(18), ADSL(1), ADSS(1), AK2(1), AK5(7), ALLC(3), AMPD1(4), AMPD2(1), AMPD3(7), ATIC(1), ATP5A1(3), ATP5B(2), ATP5C1(3), ATP5G2(2), ATP5G3(1), CANT1(1), DCK(1), ENPP1(8), ENPP3(6), ENTPD1(1), ENTPD2(2), GART(3), GDA(7), GUCY1A2(12), GUCY1A3(7), GUCY1B3(4), GUCY2C(5), GUCY2D(2), GUCY2F(6), GUK1(2), HPRT1(1), IMPDH1(2), IMPDH2(1), NPR1(3), NPR2(4), NT5E(2), PAPSS2(1), PDE1A(2), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(2), PDE5A(4), PDE6B(3), PDE6C(1), PDE7B(1), PDE8A(5), PDE9A(2), PFAS(6), PKLR(4), PKM2(3), POLB(1), POLD1(2), POLD2(1), POLE(7), POLG(2), POLL(2), POLQ(18), POLR1B(2), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLRMT(2), PPAT(2), PRPS1(2), PRPS1L1(3), PRPS2(1), RRM1(1), RRM2(1) 34429116 283 128 283 87 76 103 16 53 35 0 0.32 1.00 1.00 298 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(3), ACVRL1(3), AKT1(1), BMPR1A(3), BMPR2(1), BUB1(4), CDKL1(1), CDKL2(2), CDS1(2), CLK1(3), CLK2(2), CLK4(2), COL4A3BP(3), CSNK2A1(3), DGKA(3), DGKB(5), DGKD(6), DGKE(4), DGKG(2), DGKQ(1), DGKZ(4), IMPA1(2), INPP1(1), INPP4A(5), INPP4B(6), INPP5A(4), INPPL1(4), ITPKA(1), ITPKB(6), MOS(4), NEK1(3), OCRL(8), PAK4(1), PIK3C2A(6), PIK3C2B(6), PIK3C2G(8), PIK3CA(29), PIK3CB(4), PIK3CG(17), PIM2(2), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCG1(3), PLCG2(4), PLK3(3), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCQ(4), PRKCZ(1), PRKD1(11), PRKG1(6), RAF1(1), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KA4(1), RPS6KB1(1), STK11(3), VRK1(1) 30413080 277 127 263 71 92 88 19 46 32 0 0.10 1.00 1.00 299 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(2), ACTB(1), ACTG1(2), ACTN1(2), ACTN2(9), ACTN3(2), ACTN4(5), ACVR1B(3), ACVR1C(4), BAIAP2(2), CDC42(1), CDH1(3), CREBBP(17), CSNK2A1(3), CTNNA1(1), CTNNA2(27), CTNNA3(16), CTNNB1(4), CTNND1(4), EGFR(7), EP300(9), ERBB2(2), FARP2(7), FER(3), FGFR1(1), FYN(5), IGF1R(1), INSR(9), IQGAP1(8), LEF1(3), LMO7(7), MAP3K7(2), MAPK1(1), MAPK3(1), MET(4), MLLT4(4), NLK(2), PARD3(8), PTPN1(1), PTPRB(17), PTPRF(6), PTPRJ(4), PTPRM(6), PVRL1(3), PVRL3(3), PVRL4(6), RAC1(1), SMAD2(2), SMAD3(1), SMAD4(5), SNAI1(4), SNAI2(3), SORBS1(5), SSX2IP(2), TCF7(1), TCF7L2(1), TGFBR2(3), TJP1(9), VCL(2), WAS(4), WASF1(1), WASF3(1), WASL(2), YES1(1) 32064742 286 126 284 89 80 91 19 61 35 0 0.63 1.00 1.00 300 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(10), ADCY2(17), ADCY3(7), ADCY4(4), ADCY5(1), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), AKAP1(2), AKAP11(7), AKAP12(4), AKAP3(8), AKAP4(6), AKAP5(1), AKAP6(15), AKAP7(2), AKAP8(5), AKAP9(11), ARHGEF1(2), CALM2(1), CHMP1B(1), GNA11(1), GNA12(2), GNA13(1), GNA14(3), GNA15(1), GNAI3(1), GNAL(1), GNAZ(3), GNB1(1), GNB2(2), GNB3(2), GNB5(1), GNG12(1), GNG4(2), GNG5(1), HRAS(4), ITPR1(6), KCNJ3(11), KRAS(2), NRAS(1), PDE1A(2), PDE1B(3), PDE1C(12), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(2), PDE7A(1), PDE7B(1), PDE8A(5), PDE8B(3), PLCB3(4), PPP3CA(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCI(5), PRKCQ(4), PRKCZ(1), PRKD1(11), PRKD3(2), SLC9A1(3), USP5(2) 31415042 285 124 284 62 85 97 19 50 34 0 0.0035 1.00 1.00 301 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(1), AKT3(3), BCL2L1(1), CDC42(1), CDKN2A(26), CREB1(1), CREB3(2), CREB5(3), ERBB4(13), F2RL2(1), GAB1(2), GADD45A(1), GSK3A(3), IGF1(3), INPPL1(4), IRS1(6), IRS2(2), IRS4(2), MET(4), MYC(1), NOLC1(4), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK7(6), PARD3(8), PARD6A(1), PDK1(1), PIK3CA(29), PIK3CD(4), PPP1R13B(5), PREX1(14), PTEN(16), PTK2(6), PTPN1(1), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KB1(1), SFN(2), SHC1(2), SLC2A4(2), SOS1(11), SOS2(7), TSC1(5), TSC2(5), YWHAB(1), YWHAQ(1) 20733974 226 124 209 56 76 62 10 35 43 0 0.12 1.00 1.00 302 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(6), AMY2B(7), ASCC3(10), ATP13A2(1), DDX18(2), DDX19A(1), DDX23(3), DDX4(2), DDX41(2), DDX50(1), DDX51(1), DDX52(1), DDX54(3), DDX55(1), DDX56(1), ENPP1(8), ENPP3(6), ENTPD7(2), EP400(9), ERCC3(1), G6PC(3), G6PC2(3), GANC(5), GBA(4), GBA3(11), GBE1(2), GCK(5), GPI(5), GUSB(2), GYS1(1), GYS2(4), HK1(3), HK2(5), HK3(5), IFIH1(4), MGAM(5), MOV10L1(7), NUDT8(1), PGM1(1), PYGB(4), PYGL(3), PYGM(6), RAD54L(1), SETX(12), SI(46), SKIV2L2(2), SMARCA2(4), TREH(1), UGDH(2), UGP2(4), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(3), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2), UXS1(4) 33377848 286 123 286 77 68 105 26 53 34 0 0.18 1.00 1.00 303 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(8), BDKRB1(2), BDKRB2(3), C1QA(2), C1QB(2), C1R(3), C1S(3), C2(2), C3(5), C3AR1(2), C4BPA(2), C5(1), C5AR1(3), C6(18), C7(12), C8A(6), C8B(4), C9(3), CD46(2), CD55(1), CFB(2), CFH(7), CFI(3), CPB2(3), CR1(7), CR2(11), F10(3), F11(3), F12(1), F13A1(5), F13B(12), F2R(2), F3(1), F5(19), F7(2), F8(9), F9(7), FGA(5), FGB(4), FGG(2), KLKB1(7), KNG1(9), MASP1(10), MASP2(1), MBL2(4), PLAT(1), PLAU(2), PLAUR(2), PLG(2), PROS1(5), SERPINA1(1), SERPINA5(3), SERPINC1(7), SERPIND1(2), SERPINF2(3), SERPING1(3), VWF(17) 24322810 271 123 271 80 71 102 21 50 27 0 0.40 1.00 1.00 304 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(6), ALG1(1), ALG10B(1), ALG12(1), ALG13(8), ALG2(3), ALG6(2), ALG8(1), ALG9(1), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT1(1), B4GALT3(3), B4GALT4(3), B4GALT5(2), C1GALT1C1(1), CHPF(2), CHST1(2), CHST11(2), CHST12(1), CHST2(4), CHST3(2), CHST4(2), CHST6(5), CHSY1(2), DDOST(1), EXT1(2), EXT2(1), EXTL1(3), EXTL2(1), EXTL3(1), FUT8(2), GALNT1(2), GALNT10(2), GALNT11(2), GALNT12(3), GALNT13(13), GALNT14(5), GALNT2(2), GALNT3(3), GALNT5(7), GALNT6(2), GALNT8(3), GALNT9(1), GALNTL1(4), GALNTL4(4), GALNTL5(3), GANAB(5), GCNT1(3), GCNT3(2), HS3ST2(2), HS3ST3A1(1), HS3ST5(4), HS6ST1(5), HS6ST3(3), MAN1A1(4), MAN1A2(5), MAN1C1(3), MAN2A1(4), MGAT1(2), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(5), MGAT5B(4), NDST1(4), NDST2(2), NDST3(4), NDST4(13), OGT(2), RPN1(1), ST3GAL1(4), ST3GAL4(2), ST6GAL1(2), ST6GALNAC1(3), STT3B(1), UST(1), WBSCR17(11), XYLT1(5) 29441022 242 122 240 83 66 96 18 39 23 0 0.58 1.00 1.00 305 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(9), ASH2L(4), CARM1(1), CTCFL(2), DOT1L(5), EED(2), EHMT1(5), EHMT2(1), EZH1(4), EZH2(4), FBXO11(6), HCFC1(1), HSF4(1), JMJD6(1), KDM6A(7), MEN1(3), MLL(5), MLL2(41), MLL3(30), MLL4(10), MLL5(4), NSD1(10), OGT(2), PRDM2(6), PRDM7(1), PRDM9(14), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), RBBP5(1), SATB1(4), SETD1A(8), SETD2(5), SETD8(1), SETDB1(3), SMYD3(1), STK38(4), SUV39H1(2), SUV39H2(2), SUV420H1(6), SUZ12(4), WHSC1(1), WHSC1L1(16) 31772644 250 121 249 58 69 75 11 36 58 1 0.11 1.00 1.00 306 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), AKT3(3), BCAR1(6), CAPN1(2), CAPN10(5), CAPN11(2), CAPN2(2), CAPN3(8), CAPN5(2), CAPN6(6), CAPN7(1), CAPN9(1), CAV2(1), CAV3(1), CDC42(1), DOCK1(4), FYN(5), ILK(1), ITGA10(8), ITGA11(6), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(13), ITGA9(2), ITGAD(8), ITGAE(4), ITGAL(1), ITGAM(7), ITGAV(4), ITGAX(9), ITGB1(5), ITGB2(5), ITGB3(4), ITGB4(8), ITGB6(1), ITGB7(1), ITGB8(4), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(2), MAPK10(1), MAPK4(2), MAPK6(4), MAPK7(1), MYLK2(3), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PDPK1(1), PIK3R2(4), PTK2(6), PXN(3), RAC1(1), RAP1B(1), RAPGEF1(4), RHO(1), ROCK1(5), ROCK2(3), SDCCAG8(6), SHC1(2), SHC3(2), SORBS1(5), SOS1(11), TLN1(6), TNS1(6), VASP(2), VAV2(4), VAV3(1), VCL(2), ZYX(1) 36000144 268 121 267 95 75 102 20 46 25 0 0.76 1.00 1.00 307 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1B(3), ACVR1C(4), ACVR2A(4), ACVRL1(3), AMHR2(7), BMP4(1), BMP5(8), BMPR1A(3), BMPR1B(1), BMPR2(1), CDKN2B(1), CHRD(6), COMP(1), CREBBP(17), CUL1(4), DCN(1), E2F5(2), EP300(9), GDF5(4), GDF6(2), ID2(1), IFNG(1), INHBA(5), INHBB(1), INHBC(1), LEFTY2(3), LTBP1(16), MAPK1(1), MAPK3(1), MYC(1), NODAL(3), PITX2(3), PPP2R1A(8), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), RBL1(5), RBL2(7), RBX1(1), ROCK1(5), ROCK2(3), RPS6KB1(1), RPS6KB2(1), SKP1(1), SMAD1(3), SMAD2(2), SMAD3(1), SMAD4(5), SMAD7(2), SMAD9(1), SMURF1(2), SP1(2), TFDP1(3), TGFB1(1), TGFB2(3), TGFBR2(3), THBS1(1), THBS2(16), THBS3(3), THBS4(1), TNF(1), ZFYVE16(3), ZFYVE9(6) 26550302 216 118 214 64 62 75 14 37 28 0 0.46 1.00 1.00 308 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(10), ADCY2(17), ADCY3(7), ADCY4(4), ADCY5(1), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CREB1(1), CREB3(2), CREB3L2(2), CREB3L3(1), CREB3L4(2), CREBBP(17), CTNNB1(4), DCT(4), DVL1(3), DVL3(2), EDNRB(5), EP300(9), FZD1(1), FZD10(2), FZD2(1), FZD3(5), FZD4(1), FZD6(3), FZD7(2), FZD8(1), FZD9(2), GNAI1(3), GNAI3(1), GNAS(6), HRAS(4), KIT(7), KRAS(2), LEF1(3), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), POMC(1), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), RAF1(1), TCF7(1), TCF7L2(1), TYR(10), TYRP1(2), WNT1(1), WNT10A(1), WNT10B(4), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(2), WNT5A(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT9A(1), WNT9B(1) 29134506 264 117 263 81 55 106 25 53 25 0 0.26 1.00 1.00 309 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(3), ABL2(7), AKT1(1), AKT3(3), ARAF(3), AREG(3), BRAF(8), BTC(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CBL(3), CBLB(7), CDKN1A(2), CRKL(1), EGF(6), EGFR(7), ERBB2(2), ERBB3(4), ERBB4(13), EREG(1), GAB1(2), HBEGF(1), HRAS(4), JUN(3), KRAS(2), MAP2K1(2), MAP2K2(1), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MYC(1), NCK1(2), NCK2(1), NRAS(1), NRG1(3), NRG2(3), NRG3(9), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK7(6), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(17), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(3), PLCG2(4), PRKCA(5), PRKCG(9), PTK2(6), RAF1(1), RPS6KB1(1), RPS6KB2(1), SHC1(2), SHC2(4), SHC3(2), SHC4(5), SOS1(11), SOS2(7), STAT5A(2), TGFA(1) 27545856 261 116 246 71 91 89 11 39 31 0 0.15 1.00 1.00 310 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(1), AKT3(3), CARD11(5), CBL(3), CBLB(7), CD3D(1), CD4(1), CD40LG(3), CD8A(2), CD8B(1), CDC42(1), CHP(2), CHUK(2), CTLA4(1), FOS(2), FYN(5), HRAS(4), ICOS(2), IFNG(1), IKBKB(2), IL10(2), IL4(2), ITK(2), JUN(3), KRAS(2), LCK(3), LCP2(2), MALT1(1), MAP3K14(1), NCK1(2), NCK2(1), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NRAS(1), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK7(6), PDCD1(2), PDK1(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(17), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKCQ(4), PTPRC(7), RASGRP1(1), SOS1(11), SOS2(7), TEC(4), TNF(1), VAV1(7), VAV2(4), VAV3(1), ZAP70(4) 27210860 242 113 228 59 86 72 16 39 29 0 0.066 1.00 1.00 311 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(1), AKT3(3), BTK(7), FCER1A(3), FCER1G(1), FYN(5), GAB2(1), HRAS(4), IL3(1), IL4(2), INPP5D(8), KRAS(2), LCP2(2), LYN(2), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), MAPK9(1), MS4A2(4), NRAS(1), PDK1(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(17), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCG1(3), PLCG2(4), PRKCA(5), PRKCD(2), PRKCE(3), RAC1(1), RAF1(1), SOS1(11), SOS2(7), SYK(1), TNF(1), VAV1(7), VAV2(4), VAV3(1) 19382064 206 112 193 47 67 69 17 26 27 0 0.026 1.00 1.00 312 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(1), AKT3(3), BLNK(1), BTK(7), CARD11(5), CD19(2), CD22(6), CD79A(1), CD81(2), CHP(2), CHUK(2), CR2(11), FCGR2B(3), FOS(2), HRAS(4), IKBKB(2), INPP5D(8), JUN(3), KRAS(2), LILRB3(4), LYN(2), MALT1(1), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NRAS(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(17), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG2(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), RAC1(1), RASGRP3(7), SYK(1), VAV1(7), VAV2(4), VAV3(1) 19934576 203 111 189 51 70 61 13 30 29 0 0.090 1.00 1.00 313 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 ANPEP(8), CD14(2), CD19(2), CD1A(4), CD1B(6), CD1C(6), CD1D(4), CD1E(4), CD2(1), CD22(6), CD33(3), CD34(2), CD36(1), CD37(3), CD38(2), CD3D(1), CD4(1), CD44(5), CD5(2), CD55(1), CD7(1), CD8A(2), CD8B(1), CD9(1), CR1(7), CR2(11), CSF1(2), CSF1R(3), CSF2RA(7), CSF3R(7), DNTT(2), EPOR(2), FCER2(1), FCGR1A(1), FLT3(7), GP5(4), GP9(2), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), IL11RA(1), IL1A(1), IL1B(1), IL1R1(1), IL1R2(3), IL3(1), IL4(2), IL4R(2), IL5RA(3), IL6(1), IL6R(1), IL7(1), IL7R(8), IL9R(6), ITGA1(4), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGAM(7), ITGB3(4), KIT(7), MME(9), MS4A1(2), TFRC(2), TNF(1), TPO(10) 21851636 229 109 228 79 52 85 11 55 26 0 0.80 1.00 1.00 314 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(1), IMPA1(2), INPP1(1), INPP4A(5), INPP4B(6), INPP5A(4), INPP5B(7), INPP5E(2), INPPL1(4), IPMK(2), ITPK1(3), ITPKA(1), ITPKB(6), MIOX(1), OCRL(8), PI4KA(7), PI4KB(1), PIK3C3(5), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(17), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(4), PIP5K1B(2), PIP5K1C(2), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCD3(1), PLCE1(13), PLCG1(3), PLCG2(4), PLCZ1(5), PTEN(16), SYNJ1(4), SYNJ2(3) 19944722 210 108 195 51 70 62 7 38 33 0 0.047 1.00 1.00 315 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(1), AKT3(3), BCR(2), BTK(7), CD19(2), CDKN2A(26), FLOT1(1), FLOT2(1), GAB1(2), ITPR1(6), ITPR2(13), ITPR3(4), LYN(2), NR0B2(1), PDK1(1), PHF11(1), PIK3CA(29), PITX2(3), PLCG2(4), PPP1R13B(5), PREX1(14), PTEN(16), PTPRC(7), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KB1(1), SYK(1), TEC(4), VAV1(7) 14958942 173 108 155 39 63 42 8 26 34 0 0.049 1.00 1.00 316 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(1), AKT3(3), CASP8(2), CCL3(2), CD14(2), CD40(2), CD80(3), CD86(3), CHUK(2), FADD(1), FOS(2), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IKBKB(2), IKBKE(3), IL12A(1), IL12B(3), IL1B(1), IL6(1), IRAK1(3), IRF3(1), JUN(3), LBP(4), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP2K7(1), MAP3K7(2), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), MAPK9(1), NFKB1(2), NFKB2(2), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(17), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), RAC1(1), RELA(3), SPP1(1), STAT1(2), TBK1(3), TLR1(2), TLR2(3), TLR3(2), TLR4(10), TLR5(2), TLR7(3), TLR8(3), TLR9(2), TNF(1), TOLLIP(1), TRAF3(3), TRAF6(5) 24041926 201 107 186 62 79 53 11 34 24 0 0.43 1.00 1.00 317 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(1), AKT3(3), CASP9(3), CDC42(1), CHP(2), HRAS(4), KDR(15), KRAS(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPKAPK2(2), MAPKAPK3(1), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NOS3(2), NRAS(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(17), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCG1(3), PLCG2(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKCA(5), PRKCG(9), PTK2(6), PXN(3), RAC1(1), RAF1(1), SH2D2A(2), SHC2(4), SPHK2(1) 19343972 205 105 191 57 76 68 12 23 26 0 0.15 1.00 1.00 318 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(3), CDC40(2), CLK2(2), CLK3(1), CLK4(2), COL2A1(12), CPSF1(4), CPSF2(3), CPSF3(2), CPSF4(2), CSTF2(2), CSTF2T(3), CSTF3(1), DDX1(6), DHX15(3), DHX16(2), DHX38(2), DHX8(2), DHX9(5), DICER1(13), FUS(1), METTL3(1), NCBP1(2), NONO(1), NXF1(2), PAPOLA(1), POLR2A(2), PRPF3(1), PRPF4(2), PRPF4B(6), PRPF8(7), PSKH1(1), PTBP2(3), RBM17(1), RBM5(2), RNMT(2), RNPS1(1), SF3A1(1), SF3A2(2), SF3A3(2), SF3B1(4), SF3B2(4), SF3B4(1), SF4(3), SFRS12(1), SFRS14(5), SFRS2(2), SFRS6(1), SFRS7(2), SFRS8(2), SFRS9(1), SNRPA(2), SNRPA1(1), SNRPB(3), SNRPD1(2), SNRPD2(1), SNRPD3(1), SNRPF(1), SNRPN(5), SPOP(1), SRPK1(3), SRRM1(4), SUPT5H(2), U2AF2(1), XRN2(3) 28344008 169 105 167 42 46 59 11 34 19 0 0.27 1.00 1.00 319 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(3), AKT1(1), BDKRB2(3), CALM2(1), CHRNA1(4), FLT1(11), FLT4(5), KDR(15), NOS3(2), PDE2A(4), PDE3A(7), PDE3B(5), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), PRKG1(6), PRKG2(4), RYR2(112), SLC7A1(4), SYT1(4) 11048104 201 105 199 56 46 75 18 36 26 0 0.20 1.00 1.00 320 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(5), AGTR2(3), ATP8A1(9), AVPR1A(3), AVPR1B(2), AVPR2(4), BDKRB1(2), BDKRB2(3), C3AR1(2), CCKAR(2), CCKBR(2), CCR1(3), CCR10(1), CCR2(1), CCR3(1), CCR4(3), CCR5(2), CCR6(2), CCR8(1), CX3CR1(3), CXCR3(1), CXCR4(5), EDNRA(1), EDNRB(5), FPR1(1), FSHR(15), GALR1(5), GALT(1), GHSR(4), GPR77(3), GRPR(3), LHCGR(9), MC2R(2), MC3R(2), MC4R(2), MC5R(3), NMBR(3), NPY1R(3), NPY2R(4), NPY5R(4), NTSR1(4), NTSR2(3), OPRD1(2), OPRK1(1), OPRL1(2), OPRM1(6), OXTR(1), PPYR1(4), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(2), TACR1(3), TACR2(1), TACR3(4), TRHR(2), TSHR(5) 13951284 177 105 177 68 30 72 11 36 28 0 0.53 1.00 1.00 321 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(1), AKT3(3), BRD4(3), CAP1(2), CBL(3), CDC42(1), CDKN2A(26), F2RL2(1), FLOT1(1), FLOT2(1), GSK3A(3), INPPL1(4), IRS1(6), IRS2(2), IRS4(2), LNPEP(2), MAPK1(1), MAPK3(1), PARD3(8), PARD6A(1), PDK1(1), PIK3CA(29), PIK3CD(4), PIK3R1(2), PPYR1(4), PTEN(16), PTPN1(1), RAF1(1), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KB1(1), SERPINB6(4), SFN(2), SHC1(2), SLC2A4(2), SORBS1(5), SOS1(11), SOS2(7), YWHAB(1), YWHAQ(1) 15893442 175 104 158 35 65 41 7 28 34 0 0.025 1.00 1.00 322 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(1), ALG6(2), CCKBR(2), CCR2(1), CCR3(1), CCR5(2), CELSR1(11), CELSR2(8), CELSR3(10), CHRM2(8), CHRM3(5), CXCR3(1), DRD4(1), EDNRA(1), EMR2(4), EMR3(5), F2R(2), FSHR(15), GHRHR(4), GPR116(5), GPR132(1), GPR133(2), GPR135(2), GPR143(2), GPR17(4), GPR18(2), GPR55(1), GPR56(1), GPR61(2), GPR77(3), GRM1(12), GRPR(3), HRH4(4), LGR6(2), LPHN2(7), LPHN3(17), LTB4R2(1), NTSR1(4), OR2M4(4), OR8G2(3), P2RY13(1), PTGFR(5), SMO(1), SSTR2(2), TAAR5(5), TSHR(5), VN1R1(4) 17894696 189 103 189 63 52 67 14 38 18 0 0.20 1.00 1.00 323 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(1), AKT3(3), BCR(2), BLNK(1), BTK(7), CD19(2), CD22(6), CD81(2), CR2(11), DAG1(2), FLOT1(1), FLOT2(1), GSK3A(3), INPP5D(8), ITPR1(6), ITPR2(13), ITPR3(4), LYN(2), MAP4K1(3), MAPK1(1), MAPK3(1), NFATC1(3), NFATC2(4), NR0B2(1), PDK1(1), PIK3CA(29), PIK3CD(4), PIK3R1(2), PLCG2(4), PPP1R13B(5), PPP3CA(4), PPP3CB(4), PPP3CC(2), PTPRC(7), RAF1(1), SHC1(2), SOS1(11), SOS2(7), SYK(1), VAV1(7) 19862308 179 102 165 55 63 56 8 30 22 0 0.42 1.00 1.00 324 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 AKT1(1), AKT3(3), ARHGAP1(1), ARHGAP4(2), ARHGEF11(8), BTK(7), CDC42(1), CFL1(2), CFL2(1), GDI1(2), GDI2(2), INPPL1(4), ITPR1(6), ITPR2(13), ITPR3(4), MYLK(8), MYLK2(3), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK7(6), PDK1(1), PIK3CA(29), PIK3CD(4), PIK3CG(17), PIK3R1(2), PITX2(3), PPP1R13B(5), PTEN(16), RACGAP1(3), RHO(1), ROCK1(5), ROCK2(3), WASF1(1), WASL(2) 18863016 171 100 155 43 51 55 8 28 29 0 0.11 1.00 1.00 325 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(1), CABIN1(5), CALM2(1), CAMK2B(2), CAMK4(3), CDKN1A(2), CNR1(5), CREBBP(17), CSNK2A1(3), CTLA4(1), EGR2(6), EGR3(2), EP300(9), FCER1A(3), FCGR3A(4), FKBP1B(1), FOS(2), FOSL1(1), GATA3(6), GRLF1(13), GSK3A(3), HRAS(4), ICOS(2), IFNA1(1), IFNB1(2), IFNG(1), IL10(2), IL1B(1), IL3(1), IL4(2), IL6(1), ITK(2), KPNA5(2), MAP2K7(1), MAPK14(1), MAPK8(2), MAPK9(1), MEF2A(3), MEF2D(3), MYF5(6), NCK2(1), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NPPB(1), NUP214(4), OPRD1(2), P2RX7(2), PAK1(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(7), RELA(3), SFN(2), SLA(2), SP1(2), SP3(1), TGFB1(1), TNF(1), TRPV6(3), VAV1(7), VAV2(4), VAV3(1), XPO5(2) 24364106 205 97 204 57 55 72 15 37 26 0 0.25 1.00 1.00 326 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(6), AMY2B(7), ENPP1(8), ENPP3(6), G6PC(3), GANAB(5), GBA3(11), GBE1(2), GCK(5), GPI(5), GUSB(2), GYS1(1), GYS2(4), HK1(3), HK2(5), HK3(5), MGAM(5), PGM1(1), PYGB(4), PYGL(3), PYGM(6), SI(46), UCHL3(1), UGDH(2), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2B15(3), UGT2B4(8), UXS1(4) 15402162 179 97 179 38 38 73 12 35 21 0 0.013 1.00 1.00 327 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(3), BRAF(8), CHUK(2), CREB1(1), DAXX(3), FOS(2), HRAS(4), IKBKB(2), JUN(3), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K5(1), MAP2K6(2), MAP2K7(1), MAP3K1(3), MAP3K11(2), MAP3K12(4), MAP3K13(5), MAP3K14(1), MAP3K3(1), MAP3K4(4), MAP3K5(4), MAP3K6(1), MAP3K7(2), MAP3K9(4), MAP4K1(3), MAP4K2(1), MAP4K3(7), MAP4K4(7), MAP4K5(1), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK4(2), MAPK6(4), MAPK7(1), MAPK8(2), MAPK9(1), MAPKAPK2(2), MAPKAPK3(1), MAPKAPK5(3), MEF2A(3), MEF2C(4), MEF2D(3), MKNK2(1), MYC(1), NFKB1(2), PAK1(2), PAK2(1), RAC1(1), RAF1(1), RELA(3), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KA4(1), RPS6KA5(4), RPS6KB1(1), RPS6KB2(1), SHC1(2), SP1(2), STAT1(2), TGFB1(1), TGFB2(3), TRADD(1) 25638942 162 96 160 61 53 59 8 22 20 0 0.90 1.00 1.00 328 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(1), AKT3(3), BRAF(8), CAB39(1), DDIT4(2), EIF4B(5), FIGF(2), HIF1A(1), IGF1(3), MAPK1(1), MAPK3(1), PDPK1(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(17), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PRKAA2(5), RICTOR(3), RPS6(1), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KA6(5), RPS6KB1(1), RPS6KB2(1), STK11(3), TSC1(5), TSC2(5), ULK1(4), ULK2(5), VEGFC(6) 14367982 146 93 132 31 54 41 11 18 22 0 0.047 1.00 1.00 329 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(8), CPEB1(1), EGFR(7), ERBB2(2), ERBB4(13), ETS1(2), ETV6(4), FMN2(28), KRAS(2), MAP2K1(2), MAPK1(1), MAPK3(1), NOTCH1(16), NOTCH2(10), NOTCH3(7), NOTCH4(4), PIWIL1(8), PIWIL2(4), PIWIL3(4), RAF1(1), SOS1(11), SOS2(7), SPIRE1(2), SPIRE2(6) 14019992 151 93 149 46 37 53 7 29 25 0 0.57 1.00 1.00 330 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(9), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADIPOQ(2), ADIPOR2(4), AKT1(1), AKT3(3), CAMKK2(1), CD36(1), CHUK(2), CPT1A(5), CPT1B(3), CPT1C(3), CPT2(2), G6PC(3), G6PC2(3), IKBKB(2), IRS1(6), IRS2(2), IRS4(2), JAK1(2), JAK2(4), JAK3(7), LEPR(15), MAPK10(1), MAPK8(2), MAPK9(1), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), PCK1(2), PCK2(1), POMC(1), PPARA(1), PPARGC1A(6), PRKAA2(5), PRKAB2(1), PRKAG2(4), PRKAG3(3), PRKCQ(4), PTPN11(3), RELA(3), RXRA(2), RXRG(7), SLC2A1(1), SLC2A4(2), SOCS3(1), STAT3(2), STK11(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TYK2(8) 22215824 165 93 164 45 44 57 10 25 29 0 0.13 1.00 1.00 331 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(3), CRKL(1), DOCK1(4), FOS(2), GAB1(2), HGF(10), HRAS(4), ITGA1(4), ITGB1(5), JUN(3), MAP2K1(2), MAP2K2(1), MAP4K1(3), MAPK1(1), MAPK3(1), MAPK8(2), MET(4), PAK1(2), PIK3CA(29), PIK3R1(2), PTEN(16), PTK2(6), PTPN11(3), PXN(3), RAF1(1), RAP1A(1), RAP1B(1), RASA1(8), SOS1(11), STAT3(2) 11788406 137 93 122 37 54 29 4 25 25 0 0.49 1.00 1.00 332 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(1), APC(9), AR(6), BRAF(8), CCL16(1), DAG1(2), EGFR(7), GNA11(1), GNA15(1), GNAI1(3), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(13), ITPR3(4), KCNJ3(11), KCNJ5(2), KCNJ9(3), MAPK1(1), MAPK10(1), MAPK14(1), PHKA2(4), PIK3CA(29), PIK3CD(4), PIK3R1(2), PITX2(3), PTX3(2), RAF1(1) 14376526 133 93 118 26 48 43 6 25 11 0 0.010 1.00 1.00 333 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(2), APOA2(1), CD36(1), CITED2(1), CPT1B(3), CREBBP(17), EHHADH(1), EP300(9), FABP1(1), HSD17B4(1), JUN(3), LPL(3), MAPK1(1), MAPK3(1), ME1(2), MRPL11(1), MYC(1), NCOA1(6), NCOR1(8), NCOR2(6), NR0B2(1), NR1H3(2), NRIP1(3), PIK3CA(29), PIK3R1(2), PPARA(1), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), PRKCA(5), RB1(12), RELA(3), RXRA(2), SP1(2), STAT5A(2), TNF(1) 16899320 144 92 129 43 50 41 5 28 20 0 0.54 1.00 1.00 334 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(3), AGT(1), AKT1(1), CALM2(1), CALR(1), CAMK1G(3), CAMK4(3), CREBBP(17), CSNK1A1(2), ELSPBP1(1), FGF2(2), HAND1(1), HAND2(2), HRAS(4), IGF1(3), MAP2K1(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MEF2C(4), MYH2(31), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NKX2-5(2), PIK3CA(29), PIK3R1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), RAF1(1), RPS6KB1(1), SYT1(4) 13559328 161 91 148 44 57 56 9 25 14 0 0.26 1.00 1.00 335 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), AGPAT3(1), AGPAT4(1), AGPAT6(1), AKR1B1(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), CEL(1), DAK(1), DGAT1(1), DGAT2(3), DGKA(3), DGKB(5), DGKD(6), DGKE(4), DGKG(2), DGKI(13), DGKQ(1), DGKZ(4), GK(4), GK2(6), GLA(2), GPAM(3), LCT(18), LIPA(2), LIPC(2), LIPF(1), LIPG(3), LPL(3), MGLL(1), PNLIP(11), PNLIPRP1(3), PNLIPRP2(4), PNPLA3(1), PPAP2B(2) 15832032 133 90 133 53 36 58 3 26 10 0 0.85 1.00 1.00 336 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(2), INPP1(1), INPP4A(5), INPP4B(6), INPP5A(4), INPPL1(4), ITPKA(1), ITPKB(6), MIOX(1), OCRL(8), PIK3C2A(6), PIK3C2B(6), PIK3C2G(8), PIK3CA(29), PIK3CB(4), PIK3CG(17), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCG1(3), PLCG2(4) 12060390 140 89 127 36 50 43 8 21 18 0 0.15 1.00 1.00 337 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(10), CANT1(1), CDA(1), CTPS(3), CTPS2(2), DCK(1), DCTD(1), DPYD(8), DPYS(6), DTYMK(1), ENTPD1(1), ENTPD3(1), ENTPD5(1), ENTPD6(4), ENTPD8(1), NME4(1), NME7(3), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5C3(3), NT5E(2), PNPT1(2), POLA1(6), POLD1(2), POLD2(1), POLD3(1), POLE(7), POLE2(2), POLE4(1), POLR1A(3), POLR1B(2), POLR1D(1), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLR3A(1), POLR3B(2), POLR3G(1), POLR3H(2), PRIM1(3), PRIM2(15), RFC5(1), RRM1(1), RRM2(1), RRM2B(3), TXNRD1(2), TXNRD2(3), UMPS(2), UPP1(3), UPP2(1), UPRT(1) 21823512 141 88 139 56 41 47 8 18 27 0 0.96 1.00 1.00 338 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(1), ACADL(2), ACADM(1), ACOX1(2), ACOX2(1), ACOX3(5), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADIPOQ(2), ANGPTL4(1), APOA2(1), APOA5(3), APOC3(2), AQP7(1), CD36(1), CPT1A(5), CPT1B(3), CPT1C(3), CPT2(2), CYP27A1(1), CYP4A22(2), CYP7A1(5), CYP8B1(1), DBI(2), EHHADH(1), FABP1(1), FABP5(1), FABP6(1), FABP7(1), FADS2(1), GK(4), GK2(6), HMGCS2(3), ILK(1), LPL(3), ME1(2), MMP1(3), NR1H3(2), PCK1(2), PCK2(1), PDPK1(1), PLTP(2), PPARA(1), PPARD(2), RXRA(2), RXRG(7), SCD(1), SCP2(1), SLC27A1(1), SLC27A2(5), SLC27A4(2), SLC27A5(4), SLC27A6(5), SORBS1(5), UBC(1), UCP1(2) 17537806 130 86 130 52 25 50 10 29 16 0 0.90 1.00 1.00 339 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(1), AKT3(3), BCR(2), BLNK(1), BTK(7), CD19(2), DAG1(2), EPHB2(5), ITPKA(1), ITPKB(6), LYN(2), MAP2K1(2), MAP2K2(1), MAPK1(1), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(4), PI3(1), PIK3CA(29), PIK3CD(4), PIK3R1(2), PLCG2(4), PPP1R13B(5), RAF1(1), SERPINA4(7), SHC1(2), SOS1(11), SOS2(7), SYK(1), VAV1(7) 14063246 132 86 119 39 50 38 7 23 14 0 0.42 1.00 1.00 340 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP4(1), BMP5(8), BTRC(1), CSNK1A1(2), CSNK1A1L(5), CSNK1D(2), CSNK1G1(2), CSNK1G2(1), DHH(1), FBXW11(1), GLI1(3), GLI2(6), GLI3(9), HHIP(3), IHH(1), LRP2(41), PRKACB(3), PRKACG(1), PRKX(1), PTCH1(4), PTCH2(5), SHH(2), SMO(1), STK36(5), SUFU(2), WNT1(1), WNT10A(1), WNT10B(4), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(2), WNT5A(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT9A(1), WNT9B(1), ZIC2(1) 16356064 140 85 139 57 34 50 16 24 16 0 0.89 1.00 1.00 341 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(3), ADC(1), ALDH4A1(3), ALDH5A1(1), CAD(10), CPS1(27), EARS2(3), EPRS(12), GAD1(5), GAD2(6), GCLC(2), GCLM(1), GFPT1(1), GFPT2(3), GLS(4), GLS2(1), GLUD1(4), GLUD2(9), GLUL(4), GOT2(3), GPT(1), GPT2(4), GSR(4), GSS(2), NADSYN1(7), NAGK(2), PPAT(2) 10589398 125 84 124 29 30 54 6 24 11 0 0.061 1.00 1.00 342 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(1), AKT3(3), BRAF(8), DAG1(2), DRD2(4), EGFR(7), EPHB2(5), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(13), ITPR3(4), KCNJ3(11), KCNJ5(2), KCNJ9(3), MAPK1(1), PI3(1), PIK3CB(4), PITX2(3), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), RAF1(1), RGS20(1), SHC1(2), SOS1(11), SOS2(7), STAT3(2) 15734132 133 84 131 36 35 48 6 25 19 0 0.20 1.00 1.00 343 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(2), APAF1(4), ARHGDIB(2), BAG4(1), BIRC2(1), BIRC3(3), CASP2(1), CASP7(2), CASP8(2), CASP9(3), CFLAR(1), CHUK(2), CRADD(1), DAXX(3), DFFB(2), FADD(1), GSN(2), LMNA(1), MAP2K7(1), MAP3K1(3), MAP3K14(1), MAP3K5(4), MAPK8(2), MDM2(2), NFKB1(2), NUMA1(5), PAK2(1), PRKCD(2), PRKDC(12), PSEN1(3), PSEN2(3), PTK2(6), RASA1(8), RB1(12), RELA(3), SPTAN1(4), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4) 18733254 117 83 116 34 28 35 4 20 30 0 0.50 1.00 1.00 344 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), ABP1(5), ACAT1(2), ACMSD(1), AFMID(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), AOC2(2), AOC3(3), AOX1(13), ASMT(1), CARM1(1), CYP1A1(7), CYP1A2(1), CYP1B1(1), DDC(4), ECHS1(1), EHHADH(1), GCDH(2), HADH(1), HADHA(2), HSD17B4(1), INMT(3), KMO(3), KYNU(3), LCMT1(2), LCMT2(2), LNX1(2), METTL2B(1), METTL6(2), NFX1(2), OGDH(3), OGDHL(6), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), TDO2(2), TPH1(2), TPH2(6), WARS(4), WARS2(2), WBSCR22(3) 16226836 126 83 126 44 27 44 6 33 16 0 0.69 1.00 1.00 345 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(3), ACTB(1), ACTG1(2), ARHGEF2(7), CD14(2), CDC42(1), CDH1(3), CLDN1(2), CTNNB1(4), CTTN(5), FYN(5), HCLS1(3), ITGB1(5), KRT18(2), NCK1(2), NCK2(1), NCL(1), PRKCA(5), ROCK1(5), ROCK2(3), TLR4(10), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(7), TUBA3D(2), TUBA3E(5), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(1), TUBB2A(2), TUBB3(2), TUBB4(4), TUBB4Q(2), TUBB8(1), WAS(4), WASL(2), YWHAQ(1) 14019102 117 83 116 28 35 37 11 17 17 0 0.11 1.00 1.00 346 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(3), ACTB(1), ACTG1(2), ARHGEF2(7), CD14(2), CDC42(1), CDH1(3), CLDN1(2), CTNNB1(4), CTTN(5), FYN(5), HCLS1(3), ITGB1(5), KRT18(2), NCK1(2), NCK2(1), NCL(1), PRKCA(5), ROCK1(5), ROCK2(3), TLR4(10), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(7), TUBA3D(2), TUBA3E(5), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(1), TUBB2A(2), TUBB3(2), TUBB4(4), TUBB4Q(2), TUBB8(1), WAS(4), WASL(2), YWHAQ(1) 14019102 117 83 116 28 35 37 11 17 17 0 0.11 1.00 1.00 347 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(7), CALM2(1), FCER1A(3), FCER1G(1), FOS(2), HRAS(4), JUN(3), LYN(2), MAP2K1(2), MAP2K4(1), MAP2K7(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(2), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), PAK2(1), PIK3CA(29), PIK3R1(2), PLA2G4A(7), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), RAF1(1), SHC1(2), SOS1(11), SYK(1), SYT1(4), VAV1(7) 11483492 127 82 113 33 53 40 8 16 10 0 0.31 1.00 1.00 348 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), AKR1C2(1), AKR1C3(1), AKR1C4(1), ALDH3A1(2), ALDH3B2(1), CYP1A1(7), CYP1A2(1), CYP1B1(1), CYP2B6(4), CYP2C18(2), CYP2C19(8), CYP2C8(2), CYP2C9(3), CYP2F1(3), CYP2S1(1), CYP3A4(1), CYP3A43(4), CYP3A7(1), GSTA1(3), GSTA2(2), GSTA4(1), GSTA5(2), GSTM3(1), GSTM4(3), GSTM5(3), GSTP1(1), GSTZ1(2), MGST1(2), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(3), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2) 15355170 127 82 127 39 30 44 11 32 10 0 0.49 1.00 1.00 349 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(9), COL4A2(10), COL4A3(9), COL4A4(11), COL4A5(2), COL4A6(8), F10(3), F11(3), F12(1), F2R(2), F5(19), F8(9), F9(7), FGA(5), FGB(4), FGG(2), KLKB1(7), PROS1(5), SERPINC1(7), SERPING1(3) 12027460 126 82 126 31 30 54 7 21 14 0 0.36 1.00 1.00 350 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(3), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(3), G6PC2(3), GAPDH(2), GAPDHS(1), GCK(5), GPI(5), HK1(3), HK2(5), HK3(5), LDHAL6A(2), LDHAL6B(1), LDHB(3), LDHC(3), PDHA1(3), PDHA2(8), PFKL(2), PFKM(5), PFKP(2), PGAM2(1), PGAM4(1), PGK1(2), PGK2(4), PGM1(1), PKLR(4), PKM2(3), TPI1(3) 15599030 113 81 113 49 29 44 8 19 13 0 0.93 1.00 1.00 351 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(5), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOC3(3), AOX1(13), CARM1(1), DBH(1), DCT(4), DDC(4), ECH1(1), ESCO1(2), ESCO2(1), FAH(1), GOT2(3), GSTZ1(2), HGD(4), HPD(1), LCMT1(2), LCMT2(2), METTL2B(1), METTL6(2), MYST3(11), MYST4(4), PNMT(2), PNPLA3(1), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), SH3GLB1(1), TAT(1), TH(1), TPO(10), TYR(10), TYRP1(2), WBSCR22(3) 15947020 132 79 132 40 31 52 5 27 17 0 0.37 1.00 1.00 352 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(1), BRAF(8), CREB1(1), CREB3(2), CREB5(3), CREBBP(17), CRKL(1), DAG1(2), EGR1(2), EGR2(6), EGR3(2), FRS2(4), JUN(3), MAP1B(4), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), NTRK1(4), OPN1LW(3), PIK3C2G(8), PIK3CA(29), PIK3CD(4), PIK3R1(2), PTPN11(3), RPS6KA3(1), SHC1(2), TH(1) 13877414 126 79 112 39 50 42 7 18 9 0 0.49 1.00 1.00 353 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(5), ACAT1(2), ACMSD(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), AOC2(2), AOC3(3), AOX1(13), ASMT(1), CYP19A1(4), CYP1A1(7), CYP1A2(1), CYP2A13(1), CYP2A6(5), CYP2A7(1), CYP2B6(4), CYP2C18(2), CYP2C19(8), CYP2C8(2), CYP2C9(3), CYP2D6(3), CYP2F1(3), CYP2J2(1), CYP3A4(1), CYP3A7(1), CYP4B1(3), CYP4F8(3), DDC(4), ECHS1(1), EHHADH(1), GCDH(2), HADHA(2), KMO(3), KYNU(3), SDS(2), TDO2(2), TPH1(2), WARS(4), WARS2(2) 14782010 120 79 120 50 36 38 6 32 8 0 0.92 1.00 1.00 354 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(9), CCND1(1), CCND2(3), CCND3(1), CTNNB1(4), DVL1(3), DVL3(2), FOSL1(1), FZD1(1), FZD10(2), FZD2(1), FZD3(5), FZD6(3), FZD7(2), FZD8(1), FZD9(2), JUN(3), LDLR(4), MAPK10(1), MAPK9(1), MYC(1), PAFAH1B1(1), PLAU(2), PPP2R5C(6), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCI(5), PRKCQ(4), PRKCZ(1), PRKD1(11), RAC1(1), SFRP4(4), TCF7(1), WNT1(1), WNT10A(1), WNT10B(4), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT5A(1), WNT6(2), WNT7A(3), WNT7B(1) 16040470 128 79 127 38 41 53 8 18 8 0 0.28 1.00 1.00 355 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(5), AGMAT(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH4A1(3), ALDH9A1(2), AMD1(1), AOC2(2), AOC3(3), ARG1(2), ASL(4), CKB(1), CKM(2), CKMT2(3), CPS1(27), DAO(2), GATM(1), GLUD1(4), GOT2(3), NOS1(11), NOS3(2), OAT(1), ODC1(1), OTC(3), P4HA1(2), P4HA2(3), P4HA3(3), P4HB(4), PYCR1(1), RARS(4), SMS(2) 11874914 113 78 112 29 22 47 4 24 16 0 0.11 1.00 1.00 356 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(17), CTBP1(2), DLL1(1), DLL3(1), DLL4(1), DTX2(3), DTX3(2), DTX3L(3), DTX4(2), DVL1(3), DVL3(2), EP300(9), HDAC1(2), JAG1(1), JAG2(2), LFNG(1), MAML1(3), MAML2(5), MFNG(1), NCOR2(6), NCSTN(3), NOTCH1(16), NOTCH2(10), NOTCH3(7), NOTCH4(4), PSEN1(3), PSEN2(3), PSENEN(1), SNW1(2) 18674514 116 78 115 47 18 39 11 27 21 0 0.96 1.00 1.00 357 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 AKT1(1), DAG1(2), DGKA(3), ETFA(3), GCA(2), ITGA9(2), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(13), ITPR3(4), MAP2K1(2), MAPK1(1), MAPK3(1), NR1I3(1), PAK1(2), PDE3A(7), PDE3B(5), PI3(1), PIK3C2G(8), PIK3CA(29), PIK3CD(4), PIK3R1(2), RIPK3(1), SGCB(3), VASP(2) 13173602 112 78 98 32 44 37 4 16 11 0 0.26 1.00 1.00 358 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(3), CD3D(1), CTLA4(1), DAG1(2), DTYMK(1), EPHB2(5), FBXW7(11), ITK(2), ITPKA(1), ITPKB(6), LCK(3), LCP2(2), MAPK1(1), NCK1(2), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(4), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK7(6), PLCG1(3), PTPRC(7), RAF1(1), RASGRP1(1), RASGRP2(1), RASGRP3(7), RASGRP4(5), SOS1(11), SOS2(7), VAV1(7), ZAP70(4) 15032812 121 78 118 42 33 36 12 23 17 0 0.82 1.00 1.00 359 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2), AGPAT3(1), AGPAT4(1), AKR1B1(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), CEL(1), DGAT1(1), DGKA(3), DGKB(5), DGKD(6), DGKE(4), DGKG(2), DGKQ(1), DGKZ(4), GK(4), GLA(2), LCT(18), LIPC(2), LIPF(1), LIPG(3), LPL(3), PNLIP(11), PNLIPRP1(3), PNLIPRP2(4), PPAP2B(2) 13026574 104 77 104 45 28 45 3 20 8 0 0.92 1.00 1.00 360 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(7), ATP4A(6), ATP4B(2), ATP5A1(3), ATP5B(2), ATP5C1(3), ATP5G2(2), ATP5G3(1), ATP5L(1), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), COX10(1), COX4I1(1), COX4I2(1), COX6B1(1), COX6C(1), COX7B2(3), CYC1(5), NDUFA10(3), NDUFA13(2), NDUFA7(1), NDUFA9(1), NDUFAB1(1), NDUFB1(1), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFB8(2), NDUFB9(1), NDUFS1(4), NDUFS6(1), NDUFS8(1), NDUFV1(2), NDUFV2(2), PPA2(1), SDHA(3), SDHB(2), UQCRB(1), UQCRC2(1), UQCRFS1(2) 14918002 109 77 109 31 26 28 13 27 15 0 0.40 1.00 1.00 361 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(3), AGPAT3(1), AGPAT4(1), AGPAT6(1), CDS1(2), CHAT(9), CHKA(4), CHPT1(1), CRLS1(1), DGKA(3), DGKB(5), DGKD(6), DGKE(4), DGKG(2), DGKI(13), DGKQ(1), DGKZ(4), ESCO1(2), ESCO2(1), ETNK1(3), GNPAT(2), GPAM(3), GPD1(1), GPD1L(1), GPD2(2), LYPLA1(3), MYST3(11), MYST4(4), PCYT1B(2), PISD(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLD1(7), PLD2(2), PNPLA3(1), PPAP2B(2), PTDSS1(4), SH3GLB1(1) 17670772 136 77 136 53 36 52 9 22 17 0 0.89 1.00 1.00 362 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(6), ADCY4(4), ADCY6(2), ADCY8(18), CACNA1A(10), CACNA1B(10), GNAS(6), GNAT3(1), GNB1(1), GNB3(2), GRM4(3), ITPR3(4), KCNB1(1), PDE1A(2), PLCB2(5), PRKACB(3), PRKACG(1), PRKX(1), SCNN1A(1), SCNN1B(1), SCNN1G(3), TAS1R1(3), TAS1R3(3), TAS2R1(4), TAS2R10(3), TAS2R16(4), TAS2R3(2), TAS2R38(2), TAS2R39(1), TAS2R4(1), TAS2R40(3), TAS2R41(5), TAS2R42(2), TAS2R5(1), TAS2R60(8), TAS2R7(1), TAS2R8(1), TAS2R9(3), TRPM5(1) 15389346 133 76 133 53 37 43 8 34 11 0 0.81 1.00 1.00 363 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(26), B3GALT4(1), CDR1(4), DGKI(13), IL6ST(1), MRPL19(1), PIGK(1), RPL13(1), RPL14(1), RPL19(1), RPL32(1), RPL37(1), RPL3L(2), RPL4(1), RPL5(2), RPL7(1), RPL7A(1), RPL8(2), RPLP0(2), RPS11(1), RPS12(1), RPS18(1), RPS19(1), RPS2(1), RPS20(1), RPS21(1), RPS26(1), RPS6(1), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), RPS6KA6(5), RPS6KB1(1), RPS6KB2(1), RPS8(1), SLC36A2(2), TBC1D10C(3), TSPAN9(1), UBB(2), UBC(1) 14202086 98 76 98 40 28 28 8 26 8 0 0.93 1.00 1.00 364 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(2), ACTG2(6), AKT1(1), CDC42(1), CFL1(2), CFL2(1), FLNA(14), FLNC(16), FSCN2(1), FSCN3(2), GDI1(2), GDI2(2), MYH2(31), MYLK(8), MYLK2(3), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK7(6), PFN2(1), RHO(1), ROCK1(5), ROCK2(3), VASP(2), WASF1(1), WASL(2) 12829706 118 76 118 41 30 51 7 17 13 0 0.61 1.00 1.00 365 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(3), F11(3), F12(1), F13B(12), F5(19), F7(2), F8(9), F9(7), FGA(5), FGB(4), FGG(2), LPA(15), PLAT(1), PLAU(2), PLG(2), SERPINB2(4), SERPINF2(3), VWF(17) 9400892 111 75 111 24 34 40 8 18 11 0 0.081 1.00 1.00 366 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(4), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), CDC42(1), CHUK(2), EGFR(7), F11R(1), GIT1(1), HBEGF(1), IGSF5(2), IKBKB(2), JAM2(2), JUN(3), LYN(2), MAP2K4(1), MAP3K14(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK8(2), MAPK9(1), MET(4), NFKB1(2), NFKB2(2), NOD1(4), PAK1(2), PLCG1(3), PLCG2(4), PTPN11(3), PTPRZ1(9), RAC1(1), RELA(3), TJP1(9) 18745358 117 75 115 30 30 33 7 24 23 0 0.22 1.00 1.00 367 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(3), GAPDH(2), GCK(5), GPI(5), HK1(3), HK2(5), HK3(5), LDHB(3), LDHC(3), PDHA1(3), PDHA2(8), PFKM(5), PFKP(2), PGK1(2), PGM1(1), PKLR(4), PKM2(3), TPI1(3) 13074456 97 72 97 36 25 41 5 17 9 0 0.68 1.00 1.00 368 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(3), ALDH4A1(3), ALDH5A1(1), CAD(10), CPS1(27), EPRS(12), GAD1(5), GAD2(6), GCLC(2), GCLM(1), GFPT1(1), GLS(4), GLS2(1), GLUD1(4), GLUL(4), GOT2(3), GPT(1), GPT2(4), GSS(2), NADSYN1(7), PPAT(2) 8891634 103 72 102 23 22 45 5 23 8 0 0.077 1.00 1.00 369 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(3), GAPDH(2), GCK(5), GPI(5), HK1(3), HK2(5), HK3(5), LDHB(3), LDHC(3), PDHA1(3), PDHA2(8), PFKM(5), PFKP(2), PGK1(2), PGM1(1), PKLR(4), PKM2(3), TPI1(3) 13074456 97 72 97 36 25 41 5 17 9 0 0.68 1.00 1.00 370 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), AARS2(5), CARS(8), CARS2(1), DARS(1), DARS2(5), EARS2(3), EPRS(12), FARS2(2), FARSA(5), HARS(2), HARS2(2), IARS(3), IARS2(3), KARS(2), LARS(1), LARS2(3), MARS(1), NARS(4), NARS2(2), PARS2(4), RARS(4), RARS2(2), SARS(2), SARS2(3), TARS(3), TARS2(4), VARS(4), VARS2(1), WARS(4), WARS2(2), YARS(1), YARS2(2) 14534946 103 72 103 27 40 30 5 16 12 0 0.24 1.00 1.00 371 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), AKT1(1), APC(9), CAV3(1), DAG1(2), DLG4(1), EPHB2(5), GNAI1(3), ITPR1(6), ITPR2(13), ITPR3(4), KCNJ3(11), KCNJ5(2), KCNJ9(3), MAPK1(1), PITX2(3), PTX3(2), RAC1(1), RHO(1), RYR1(27) 12383282 97 72 96 27 22 35 6 20 14 0 0.20 1.00 1.00 372 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(1), AASS(11), ACAT1(2), AKR1B10(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), BBOX1(2), DLST(1), DOT1L(5), ECHS1(1), EHHADH(1), EHMT1(5), EHMT2(1), GCDH(2), HADH(1), HADHA(2), HSD17B4(1), NSD1(10), OGDH(3), OGDHL(6), PIPOX(1), PLOD1(4), PLOD2(5), PLOD3(5), RDH11(1), RDH12(2), RDH13(1), SETD1A(8), SETDB1(3), SPCS1(1), SPCS3(2), SUV39H1(2), SUV39H2(2), TMLHE(1) 15574644 105 71 105 42 20 36 7 24 18 0 0.90 1.00 1.00 373 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(3), AGPAT3(1), AGPAT4(1), AGPS(1), CDS1(2), CHAT(9), CHKA(4), CPT1B(3), DGKA(3), DGKB(5), DGKD(6), DGKE(4), DGKG(2), DGKQ(1), DGKZ(4), ETNK1(3), GNPAT(2), GPD1(1), GPD2(2), LGALS13(1), LYPLA1(3), PAFAH1B1(1), PCYT1B(2), PISD(1), PLA2G2A(1), PLA2G2E(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCB2(5), PLCG1(3), PLCG2(4), PPAP2B(2) 13498274 99 70 99 36 29 37 9 15 9 0 0.69 1.00 1.00 374 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(2), CALR(1), CANX(2), CD4(1), CD8A(2), CD8B(1), CIITA(3), CREB1(1), CTSL1(3), CTSS(2), HLA-A(7), HLA-B(1), HLA-C(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), HLA-G(2), HSP90AA1(3), HSP90AB1(3), HSPA5(4), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), KIR2DL1(2), KIR2DL3(4), KIR2DL4(1), KIR2DS4(5), KIR3DL1(6), KIR3DL2(1), KIR3DL3(1), KLRC1(1), KLRC3(2), KLRD1(1), LTA(2), NFYA(1), NFYB(1), PDIA3(1), PSME2(1), TAP1(3), TAP2(1), TAPBP(4) 12557188 103 70 101 42 30 29 8 19 16 1 0.88 1.00 1.00 375 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CDK5(1), CDK5R1(1), CFL1(2), CHN1(2), MAP3K1(3), MYL2(2), MYLK(8), NCF2(3), PAK1(2), PDGFRA(10), PIK3CA(29), PIK3R1(2), PLD1(7), PPP1R12B(5), RAC1(1), RALBP1(1), RPS6KB1(1), TRIO(8), VAV1(7), WASF1(1) 9356570 97 69 84 23 45 28 4 17 3 0 0.16 1.00 1.00 376 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(1), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(3), EIF2S2(1), ELAVL1(1), FLT1(11), FLT4(5), HIF1A(1), HRAS(4), KDR(15), NOS3(2), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), PTK2(6), PXN(3), SHC1(2), VHL(1) 9129264 100 69 87 28 44 28 4 14 10 0 0.35 1.00 1.00 377 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(2), DIAPH1(1), FYN(5), GSN(2), HRAS(4), ITGA1(4), ITGB1(5), MAP2K1(2), MAPK1(1), MAPK3(1), MYL2(2), MYLK(8), PIK3CA(29), PIK3R1(2), PTK2(6), PXN(3), RAF1(1), ROCK1(5), SHC1(2), TLN1(6) 9987046 91 68 78 18 41 25 6 16 3 0 0.080 1.00 1.00 378 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), AARS2(5), ABAT(3), ACY3(2), ADSL(1), ADSS(1), ADSSL1(2), AGXT(2), AGXT2(2), ASL(4), ASNS(5), CAD(10), DARS(1), DARS2(5), DDO(2), DLAT(1), DLD(2), GAD1(5), GAD2(6), GOT2(3), GPT(1), GPT2(4), NARS(4), NARS2(2), PC(2), PDHA1(3), PDHA2(8) 10139592 88 68 88 31 25 28 5 19 11 0 0.67 1.00 1.00 379 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(2), C1GALT1C1(1), GALNT1(2), GALNT10(2), GALNT11(2), GALNT12(3), GALNT13(13), GALNT14(5), GALNT2(2), GALNT3(3), GALNT5(7), GALNT6(2), GALNT8(3), GALNT9(1), GALNTL1(4), GALNTL4(4), GALNTL5(3), GCNT1(3), GCNT3(2), OGT(2), ST3GAL1(4), ST6GALNAC1(3), WBSCR17(11) 8621964 85 68 83 29 19 33 10 14 9 0 0.70 1.00 1.00 380 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(1), AKT3(3), GSK3A(3), IL4R(2), IRS1(6), IRS2(2), JAK1(2), JAK3(7), MAP4K1(3), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(29), PIK3CD(4), PIK3R1(2), PPP1R13B(5), RAF1(1), SHC1(2), SOS1(11), SOS2(7), STAT6(2) 9767750 95 68 82 26 36 27 2 20 10 0 0.32 1.00 1.00 381 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(6), CXCR4(5), GNAI1(3), GNB1(1), HRAS(4), MAP2K1(2), MAPK1(1), MAPK3(1), NFKB1(2), PIK3C2G(8), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), PTK2(6), PXN(3), RAF1(1), RELA(3) 7438620 85 67 72 21 37 23 5 17 3 0 0.20 1.00 1.00 382 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(2), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(3), GAPDH(2), GAPDHS(1), GCK(5), GOT2(3), GPI(5), HK1(3), HK2(5), HK3(5), LDHAL6B(1), LDHB(3), LDHC(3), MDH1(1), MDH2(1), PC(2), PCK1(2), PDHA1(3), PDHA2(8), PDHX(1), PFKL(2), PFKM(5), PFKP(2), PGAM2(1), PGK1(2), PGK2(4), PKLR(4), PKM2(3), TPI1(3) 11368504 92 66 92 42 23 35 5 18 11 0 0.93 1.00 1.00 383 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(1), APC(9), CCND1(1), CD14(2), CTNNB1(4), DVL1(3), FZD1(1), GJA1(4), GNAI1(3), IRAK1(3), LBP(4), LEF1(3), NFKB1(2), PDPK1(1), PIK3CA(29), PIK3R1(2), RELA(3), TLR4(10), TOLLIP(1), WNT1(1) 8223600 87 66 74 18 38 17 10 14 8 0 0.14 1.00 1.00 384 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 BLVRA(2), COX10(1), CP(2), CPOX(2), EARS2(3), EPRS(12), FECH(2), FTH1(2), FTMT(7), GUSB(2), HCCS(1), MMAB(1), PPOX(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(3), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2), UROD(1), UROS(1) 11379362 93 66 93 24 25 33 9 18 8 0 0.28 1.00 1.00 385 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(2), DAXX(3), EGF(6), EGFR(7), ETS1(2), FOS(2), HOXA7(2), HRAS(4), IKBKB(2), JUN(3), MAP2K1(2), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP2K7(1), MAP3K1(3), MAP3K14(1), MAP3K5(4), MAPK1(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(2), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCQ(4), RAF1(1), RELA(3), SP1(2), TNF(1), TNFRSF1A(2), TNFRSF1B(1) 13119490 92 66 90 25 28 35 6 13 10 0 0.26 1.00 1.00 386 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(5), AR(6), ESR1(6), ESR2(2), HNF4A(2), NR0B1(4), NR1D2(1), NR1H2(1), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(3), NR2E1(4), NR2F6(1), NR3C1(1), NR4A1(4), NR4A2(3), NR5A2(5), PGR(4), PPARA(1), PPARD(2), RARA(1), RARB(3), RARG(1), ROR1(3), RORA(2), RORC(2), RXRA(2), RXRG(7), THRA(1), THRB(2), VDR(4) 11215958 87 64 87 30 22 34 2 16 13 0 0.55 1.00 1.00 387 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), AKT3(3), ARHGEF11(8), CDC42(1), DLG4(1), GNA13(1), LPA(15), MAP2K4(1), MAP3K1(3), MAP3K5(4), MAPK8(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(4), PDK1(1), PHKA2(4), PI3(1), PIK3CB(4), PLD1(7), PLD2(2), PLD3(1), PTK2(6), RDX(2), ROCK1(5), ROCK2(3), SERPINA4(7), SRF(2), TBXA2R(2) 13111302 99 64 98 36 25 35 4 25 10 0 0.83 1.00 1.00 388 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(4), BAX(1), BCL2A1(2), BCL2L1(1), CASP1(1), CASP10(3), CASP2(1), CASP4(4), CASP7(2), CASP8(2), CASP9(3), CD40(2), CD40LG(3), CRADD(1), DAXX(3), DFFB(2), FADD(1), FAS(1), FASLG(1), IKBKE(3), LTA(2), MCL1(2), NFKB1(2), NGFR(1), NR3C1(1), NTRK1(4), PTPN13(9), SFRS2IP(4), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4), TRAF3(3), TRAF6(5) 11796772 83 63 82 35 25 17 5 18 18 0 0.97 1.00 1.00 389 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(5), ATF2(3), CALM2(1), EGFR(7), HRAS(4), JUN(3), MAP2K1(2), MAP2K2(1), MAP2K4(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(2), MEF2A(3), MEF2C(4), MEF2D(3), PAK1(2), PRKCA(5), PTK2(6), RAC1(1), RAF1(1), SHC1(2), SOS1(11), SYT1(4) 8992738 77 63 75 22 22 28 5 17 5 0 0.46 1.00 1.00 390 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(3), CALM2(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CDK5(1), FYN(5), GNA11(1), GNAI1(3), GNB1(1), HRAS(4), JAK2(4), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPT(4), MYLK(8), PLCG1(3), PRKCA(5), RAF1(1), SHC1(2), SOS1(11), STAT1(2), STAT3(2), STAT5A(2), SYT1(4) 11172170 80 63 80 20 20 27 10 15 8 0 0.28 1.00 1.00 391 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(1), CABIN1(5), CALM2(1), CAMK1G(3), HDAC5(1), IGF1(3), IGF1R(1), INSR(9), MAP2K6(2), MAPK14(1), MAPK7(1), MEF2A(3), MEF2C(4), MEF2D(3), MYOD1(1), NFATC1(3), NFATC2(4), PIK3CA(29), PIK3R1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), SYT1(4) 9311892 91 63 78 26 41 27 3 13 7 0 0.27 1.00 1.00 392 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(3), ACTN1(2), ACTN2(9), ACTN3(2), BCAR1(6), BCR(2), CAPN1(2), CAPNS2(1), CRKL(1), FYN(5), HRAS(4), ITGA1(4), ITGB1(5), JUN(3), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(2), PPP1R12B(5), PTK2(6), PXN(3), RAF1(1), RAP1A(1), ROCK1(5), SHC1(2), SOS1(11), TLN1(6), VCL(2), ZYX(1) 12629812 99 63 98 31 29 34 5 22 9 0 0.54 1.00 1.00 393 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(7), CALM2(1), CD79A(1), FOS(2), HRAS(4), JUN(3), LYN(2), MAP2K1(2), MAP3K1(3), MAPK14(1), MAPK3(1), MAPK8(2), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(5), RAC1(1), RAF1(1), SHC1(2), SOS1(11), SYK(1), SYT1(4), VAV1(7) 10202070 90 62 89 22 29 33 8 11 9 0 0.24 1.00 1.00 394 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(5), ACY3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(2), AMDHD1(1), AOC2(2), AOC3(3), CARM1(1), CNDP1(3), DDC(4), FTCD(3), HAL(2), HARS(2), HARS2(2), HDC(6), HNMT(3), LCMT1(2), LCMT2(2), METTL2B(1), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), PRPS1(2), PRPS2(1), UROC1(3), WBSCR22(3) 10641018 83 62 83 32 13 39 6 15 10 0 0.70 1.00 1.00 395 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(2), ARSD(1), ARSE(2), B4GALT6(2), CERK(6), DEGS1(1), ENPP7(5), GAL3ST1(1), GALC(2), GBA(4), GLA(2), LCT(18), NEU1(2), NEU2(2), NEU4(2), PPAP2B(2), SGMS1(3), SGMS2(1), SGPP1(2), SMPD1(4), SMPD2(1), SMPD3(3), SMPD4(8), SPHK2(1), SPTLC1(1), SPTLC2(3), UGCG(1), UGT8(5) 9644574 87 62 87 28 18 30 7 22 10 0 0.44 1.00 1.00 396 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2B(2), GTF2E1(2), GTF2F1(1), GTF2H1(2), GTF2H3(1), GTF2H4(2), GTF2I(2), GTF2IRD1(5), TAF1(14), TAF1L(20), TAF2(10), TAF4(3), TAF4B(4), TAF5(1), TAF5L(2), TAF6L(2), TAF7L(2), TAF9(2), TBPL2(1) 9630512 79 62 79 20 21 28 9 12 9 0 0.39 1.00 1.00 397 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ACTG2(6), ADCY3(7), ADCY9(3), ARF1(1), ARF5(4), ATP6V0A1(4), ATP6V0A2(5), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(2), ATP6V1A(4), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ERO1L(1), GNAS(6), PDIA4(4), PLCG1(3), PLCG2(4), PRKCA(5), SEC61A1(2), SEC61A2(1), SEC61G(2), TRIM23(3) 9877398 82 62 82 23 22 29 7 16 8 0 0.34 1.00 1.00 398 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(2), ADRA1B(3), ADRA1D(3), ADRA2C(2), ADRB1(1), ADRB2(4), CHRM2(8), CHRM3(5), CHRM4(1), CHRM5(3), DRD1(1), DRD2(4), DRD3(5), DRD4(1), DRD5(5), HRH1(3), HRH2(1), HTR1A(7), HTR1B(3), HTR1E(5), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(4), HTR4(3), HTR5A(4), HTR6(1), HTR7(3) 6854068 88 62 88 39 21 34 7 18 8 0 0.66 1.00 1.00 399 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(10), CANT1(1), CDA(1), CTPS(3), CTPS2(2), DCK(1), DCTD(1), DPYD(8), DPYS(6), DTYMK(1), ENTPD1(1), NT5E(2), POLB(1), POLD1(2), POLD2(1), POLE(7), POLG(2), POLL(2), POLQ(18), POLR1B(2), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLRMT(2), RRM1(1), RRM2(1), TXNRD1(2), UMPS(2), UPP1(3) 15394686 94 62 94 24 27 36 3 15 13 0 0.21 1.00 1.00 400 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 GORASP1(1), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1), MAPKAPK5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(4), PIK3CA(29), PIK3CD(4), PIK3R1(2), SYT1(4), TRAF3(3), TRAF5(2), TRAF6(5) 9025134 83 62 70 16 38 25 2 12 6 0 0.027 1.00 1.00 401 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(12), CARM1(1), CCND1(1), CREBBP(17), EP300(9), ERCC3(1), ESR1(6), GRIP1(6), GTF2A1(1), GTF2E1(2), GTF2F1(1), HDAC1(2), HDAC3(1), HDAC4(5), HDAC5(1), MEF2C(4), NCOR2(6), NR0B1(4), NRIP1(3), POLR2A(2), TBP(1) 12332730 86 61 85 30 20 31 4 20 11 0 0.75 1.00 1.00 402 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(6), CDC7(3), DIAPH2(4), GMNN(2), MCM10(4), MCM2(1), MCM3(1), MCM4(5), MCM5(6), MCM6(3), MCM7(3), ORC1L(3), ORC2L(1), ORC3L(2), ORC5L(3), POLD1(2), POLD2(1), POLD3(1), POLE(7), POLE2(2), PRIM1(3), RFC1(1), RFC4(5), RFC5(1), RPA1(1), RPA2(1), RPA4(2), UBB(2), UBC(1) 13620916 77 61 77 26 27 19 1 18 12 0 0.70 1.00 1.00 403 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(11), GABBR1(3), GPRC5A(1), GPRC5C(4), GRM1(12), GRM2(2), GRM3(14), GRM4(3), GRM5(12), GRM7(10), GRM8(13) 5579944 85 61 85 35 18 31 13 14 9 0 0.79 1.00 1.00 404 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), AKR1B10(2), B4GALT1(1), G6PC(3), G6PC2(3), GALK2(1), GALT(1), GANC(5), GCK(5), GLA(2), HK1(3), HK2(5), HK3(5), LCT(18), MGAM(5), PFKL(2), PFKM(5), PFKP(2), PGM1(1), RDH11(1), RDH12(2), RDH13(1), UGP2(4) 10438632 78 61 78 29 19 26 4 18 11 0 0.64 1.00 1.00 405 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), DLG4(1), GRIN1(1), GRIN2A(16), GRIN2B(18), GRIN2C(3), GRIN2D(3), NOS1(11), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), PRKCA(5), SYT1(4) 6859586 83 61 82 30 23 29 7 13 11 0 0.67 1.00 1.00 406 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(1), B3GALT1(3), B3GALT2(3), B3GALT4(1), B3GNT2(1), B3GNT3(4), B3GNT4(1), B4GALT1(1), B4GALT3(3), B4GALT4(3), B4GALT6(2), FUT2(1), FUT3(3), FUT5(4), FUT6(2), FUT9(5), GBGT1(2), GCNT2(2), PIGB(1), PIGF(1), PIGG(4), PIGH(1), PIGK(1), PIGL(2), PIGN(1), PIGO(2), PIGQ(1), PIGT(1), PIGX(1), PIGZ(2), ST3GAL1(4), ST3GAL4(2), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(3), ST8SIA1(3), UGCG(1) 12992398 83 60 83 37 22 32 9 11 9 0 0.87 1.00 1.00 407 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(2), ACACB(9), ACAT1(2), ACOT12(1), ACSS1(3), AKR1B1(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), DLAT(1), DLD(2), GRHPR(2), HAGHL(1), LDHAL6A(2), LDHAL6B(1), LDHB(3), LDHC(3), LDHD(6), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(2), PC(2), PCK1(2), PCK2(1), PDHA1(3), PDHA2(8), PKLR(4), PKM2(3) 12512866 80 59 80 40 23 28 4 16 9 0 0.99 1.00 1.00 408 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(7), ADRBK2(2), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CLCA1(7), CLCA2(5), CLCA4(2), CNGA3(6), CNGA4(6), CNGB1(4), GNAL(1), GUCA1A(2), GUCA1C(1), PDE1C(12), PRKACB(3), PRKACG(1), PRKG1(6), PRKG2(4), PRKX(1) 8159698 76 59 76 18 17 35 5 8 11 0 0.13 1.00 1.00 409 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(1), BCL2L1(1), CBL(3), CFLAR(1), CRKL(1), E2F1(2), FOS(2), HRAS(4), IL2RB(2), IL2RG(1), IRS1(6), JAK1(2), JAK3(7), MAPK1(1), MAPK3(1), MYC(1), NMI(2), PIK3CA(29), PIK3R1(2), RAF1(1), RPS6KB1(1), SHC1(2), SOCS3(1), SOS1(11), STAT5A(2), SYK(1) 9661662 88 59 75 21 37 26 2 15 8 0 0.14 1.00 1.00 410 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), AKT3(3), ANKRD6(1), APC(9), AXIN2(2), CER1(2), CSNK1A1(2), CTNNB1(4), DACT1(4), DKK1(4), DKK2(1), DVL1(3), FSTL1(2), GSK3A(3), LRP1(15), MVP(2), NKD1(2), NKD2(2), PSEN1(3), SENP2(3), SFRP1(1), WIF1(5) 10825070 74 59 74 26 15 32 4 13 9 1 0.69 1.00 1.00 411 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM2(1), CAMK1G(3), FPR1(1), GNA15(1), GNB1(1), HRAS(4), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(2), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), NCF2(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NFKB1(2), PAK1(2), PIK3C2G(8), PLCB1(8), PPP3CA(4), PPP3CB(4), PPP3CC(2), RAC1(1), RAF1(1), RELA(3), SYT1(4) 10298368 82 58 82 33 20 36 6 14 6 0 0.90 1.00 1.00 412 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), AADAC(3), ABAT(3), ACADS(2), ACAT1(2), ACSM1(5), AKR1B10(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH5A1(1), ALDH7A1(1), ALDH9A1(2), BDH1(4), DDHD1(5), ECHS1(1), EHHADH(1), GAD1(5), GAD2(6), HADH(1), HADHA(2), HMGCL(1), HMGCS1(1), HMGCS2(3), HSD17B4(1), ILVBL(2), OXCT1(3), PDHA1(3), PDHA2(8), PLA1A(5), PRDX6(2), RDH11(1), RDH12(2), RDH13(1) 10842514 86 58 86 36 25 32 2 19 8 0 0.91 1.00 1.00 413 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(8), BMPR1B(1), CCND2(3), DAZL(1), DMC1(1), EGR1(2), ESR2(2), FSHR(15), GJA4(1), INHA(3), LHCGR(9), MLH1(2), MSH5(3), NCOR1(8), NRIP1(3), PGR(4), PRLR(6), PTGER2(2), SMPD1(4), VDR(4), ZP2(2) 9380066 84 58 84 32 25 28 4 15 12 0 0.90 1.00 1.00 414 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(7), GNAS(6), GNB1(1), HRAS(4), IGF1R(1), ITGB1(5), KLK2(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MKNK2(1), MYC(1), NGFR(1), PDGFRA(10), PTPRR(9), RAF1(1), RPS6KA1(2), RPS6KA5(4), SHC1(2), SOS1(11), STAT3(2) 8842684 75 57 74 21 18 31 6 16 4 0 0.38 1.00 1.00 415 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(1), BCR(2), CRKL(1), FOS(2), HRAS(4), JAK2(4), JUN(3), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK3(1), MAPK8(2), MYC(1), PIK3CA(29), PIK3R1(2), RAF1(1), SOS1(11), STAT1(2), STAT5A(2) 7470838 74 57 60 15 38 16 4 13 3 0 0.12 1.00 1.00 416 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPL(3), ALPP(3), ALPPL2(1), ASCC3(10), ATP13A2(1), DDX18(2), DDX19A(1), DDX23(3), DDX4(2), DDX41(2), DDX50(1), DDX51(1), DDX52(1), DDX54(3), DDX55(1), DDX56(1), ENTPD7(2), EP400(9), ERCC3(1), FPGS(2), GCH1(1), GGH(2), IFIH1(4), MOV10L1(7), NUDT8(1), RAD54L(1), SETX(12), SKIV2L2(2), SMARCA2(4) 16887928 84 57 84 39 26 30 9 11 8 0 0.98 1.00 1.00 417 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(3), ARSB(1), FUCA1(2), FUCA2(1), GALNS(3), GBA(4), GNS(1), GUSB(2), HEXA(5), HGSNAT(1), HPSE(3), HPSE2(2), HYAL1(3), IDS(1), IDUA(2), LCT(18), MAN2B1(2), MAN2B2(3), MAN2C1(6), MANBA(2), NEU1(2), NEU2(2), NEU4(2), SPAM1(6) 9287506 77 57 77 26 19 21 6 23 8 0 0.60 1.00 1.00 418 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(3), CAPN1(2), CAPN2(2), CAPNS2(1), CXCR3(1), EGF(6), EGFR(7), HRAS(4), ITGA1(4), ITGB1(5), MAPK1(1), MAPK3(1), MYL2(2), MYLK(8), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), PTK2(6), PXN(3), TLN1(6) 8774332 72 57 71 20 19 25 6 14 8 0 0.37 1.00 1.00 419 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(5), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOC3(3), AOX1(13), DBH(1), DCT(4), DDC(4), FAH(1), GOT2(3), GSTZ1(2), HGD(4), HPD(1), PNMT(2), TAT(1), TH(1), TPO(10), TYR(10) 8507332 79 57 79 26 17 35 3 19 5 0 0.45 1.00 1.00 420 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(2), CASP10(3), CASP7(2), CASP8(2), CFLAR(1), DAXX(3), DFFB(2), FADD(1), FAF1(1), JUN(3), LMNA(1), MAP2K4(1), MAP3K1(3), MAP3K7(2), MAPK8(2), PAK1(2), PAK2(1), PRKDC(12), PTPN13(9), RB1(12), RIPK2(2), SPTAN1(4) 11176086 71 56 70 16 21 18 1 13 18 0 0.30 1.00 1.00 421 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACAA2(1), ACADL(2), ACADM(1), ACADS(2), ACADVL(1), ACAT1(2), ACOX1(2), ACOX3(5), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), CPT1A(5), CPT1B(3), CPT1C(3), CPT2(2), CYP4A22(2), DCI(1), ECHS1(1), EHHADH(1), GCDH(2), HADH(1), HADHA(2), HADHB(3), HSD17B4(1), PECI(1) 13091010 72 56 72 23 16 32 4 12 8 0 0.53 1.00 1.00 422 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(3), ACAA1(1), ACAA2(1), ACADM(1), ACADS(2), ACAT1(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH6A1(1), ALDH7A1(1), ALDH9A1(2), AOX1(13), AUH(1), BCAT1(1), BCAT2(2), BCKDHB(2), DBT(1), DLD(2), ECHS1(1), EHHADH(1), HADH(1), HADHA(2), HADHB(3), HIBADH(1), HIBCH(1), HMGCL(1), HMGCS1(1), HMGCS2(3), HSD17B4(1), MCCC1(5), MCCC2(1), MCEE(1), MUT(4), OXCT1(3), PCCA(3), PCCB(6) 11509302 81 56 81 23 24 27 5 16 9 0 0.49 1.00 1.00 423 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(5), C5(1), C6(18), C7(12), ICAM1(2), IL1A(1), IL6(1), ITGA4(4), ITGAL(1), ITGB1(5), ITGB2(5), SELP(11), SELPLG(1), TNF(1), VCAM1(5) 6663608 73 56 73 20 17 28 6 14 8 0 0.35 1.00 1.00 424 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(7), ATP4B(2), ATP6V0A1(4), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ATP7A(9), ATP7B(2), COX10(1), COX4I1(1), COX6B1(1), COX6C(1), NDUFA10(3), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFS1(4), NDUFV1(2), NDUFV2(2), PPA2(1), SDHA(3), SDHB(2), UQCRB(1), UQCRFS1(2) 10227702 74 56 74 20 17 21 7 16 13 0 0.33 1.00 1.00 425 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT1(1), AKT3(3), DAG1(2), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(13), ITPR3(4), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(4), PDK1(1), PHKA2(4), PIK3CB(4), PITX2(3), PLD1(7), PLD2(2), PLD3(1), VN1R1(4) 12040988 75 56 74 25 22 26 3 13 11 0 0.50 1.00 1.00 426 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT1(1), FBP2(1), G6PC(3), GALK2(1), GALT(1), GANAB(5), GCK(5), GLA(2), HK1(3), HK2(5), HK3(5), LCT(18), MGAM(5), PFKM(5), PFKP(2), PGM1(1) 8783054 64 55 64 28 17 23 3 13 8 0 0.84 1.00 1.00 427 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(2), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(2), EEF2K(5), EIF2AK1(1), EIF2AK3(8), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(3), EIF2S2(1), EIF4A1(5), EIF4A2(2), EIF4G1(10), EIF4G3(4), EIF5(3), EIF5B(1), ETF1(2), GSPT2(1), KIAA0664(3), PABPC1(4), PABPC3(9), PAIP1(2), SLC35A4(1) 11769716 78 55 78 24 32 18 3 14 11 0 0.73 1.00 1.00 428 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(10), CALM2(1), CREB1(1), FOS(2), GNAI1(3), GNAS(6), GNB1(1), HRAS(4), JUN(3), MAP2K1(2), MAPK3(1), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), PRKCA(5), RAF1(1), RPS6KA3(1), SYT1(4) 9325064 83 54 82 25 29 29 7 12 6 0 0.50 1.00 1.00 429 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(5), AGXT(2), AGXT2(2), AKR1B10(2), AOC2(2), AOC3(3), BHMT(2), CBS(4), CHDH(1), CHKA(4), DAO(2), DLD(2), DMGDH(2), GATM(1), GCAT(1), GLDC(4), GNMT(1), PHGDH(2), PIPOX(1), PISD(1), PSAT1(3), PSPH(2), RDH11(1), RDH12(2), RDH13(1), SARDH(6), SARS(2), SARS2(3), SDS(2), TARS(3), TARS2(4) 11568220 73 54 73 24 24 21 4 16 8 0 0.47 1.00 1.00 430 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(6), ANAPC4(3), ANAPC5(5), BTRC(1), CDC16(1), CDC20(1), CDC23(1), CDC27(3), CUL1(4), CUL3(12), FBXW11(1), FBXW7(11), ITCH(2), RBX1(1), SKP1(1), SKP2(2), SMURF1(2), UBA1(3), UBE2C(1), UBE2D1(1), UBE2D2(2), UBE2E2(2), UBE2E3(2), VHL(1), WWP1(3), WWP2(2) 10818662 74 54 72 21 18 19 8 13 16 0 0.66 1.00 1.00 431 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(4), ACE2(3), AGT(1), AGTR1(5), AGTR2(3), ANPEP(8), CMA1(2), CPA3(6), CTSA(3), CTSG(3), ENPEP(11), LNPEP(2), MAS1(3), MME(9), NLN(2), THOP1(1) 5682650 66 54 66 22 14 28 2 12 10 0 0.59 1.00 1.00 432 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(3), BCR(2), BLNK(1), FOS(2), HRAS(4), JUN(3), LYN(2), MAP2K1(2), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8IP3(3), PAPPA(8), RAC1(1), RPS6KA1(2), RPS6KA3(1), SHC1(2), SOS1(11), SYK(1), VAV1(7), VAV2(4), VAV3(1) 8588856 65 54 64 15 20 21 7 12 5 0 0.20 1.00 1.00 433 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(1), AGTR1(5), AGTR2(3), CMA1(2), COL4A1(9), COL4A2(10), COL4A3(9), COL4A4(11), COL4A5(2), COL4A6(8) 6890202 63 53 63 20 8 36 1 9 9 0 0.77 1.00 1.00 434 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(2), C1QB(2), C1R(3), C1S(3), C2(2), C3(5), C5(1), C6(18), C7(12), C8A(6), C9(3), MASP1(10), MASP2(1), MBL2(4) 5760792 72 53 72 22 18 25 7 13 9 0 0.52 1.00 1.00 435 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(5), AGXT(2), AGXT2(2), AOC2(2), AOC3(3), BHMT(2), CBS(4), CHDH(1), CHKA(4), CPT1B(3), DAO(2), DLD(2), DMGDH(2), GATM(1), GCAT(1), GLDC(4), PISD(1), PLCB2(5), PLCG1(3), PLCG2(4), PSPH(2), SARDH(6), SARS(2), TARS(3) 11341626 66 53 66 22 24 20 2 14 6 0 0.51 1.00 1.00 436 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(6), POLB(1), POLD1(2), POLD2(1), POLD3(1), POLE(7), POLE2(2), POLE4(1), POLG(2), POLG2(2), POLI(3), POLK(3), POLL(2), POLQ(18), PRIM1(3), PRIM2(15), REV1(5), REV3L(4), RFC5(1) 10986338 79 53 78 23 24 23 3 17 12 0 0.65 1.00 1.00 437 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(2), ACAT1(2), ADH5(1), AKR1B1(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), DLAT(1), DLD(2), GRHPR(2), HAGHL(1), LDHB(3), LDHC(3), LDHD(6), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(2), PC(2), PCK1(2), PDHA1(3), PDHA2(8), PKLR(4), PKM2(3) 9908548 67 53 67 31 18 26 3 13 7 0 0.96 1.00 1.00 438 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(9), ATF2(3), BMP10(1), BMP4(1), BMP5(8), BMPR1A(3), BMPR2(1), CHRD(6), CTNNB1(4), DVL1(3), FZD1(1), MAP3K7(2), MEF2C(4), MYL2(2), NKX2-5(2), NPPB(1), RFC1(1), TGFB1(1), TGFB2(3), TGFBR2(3), TGFBR3(8), WNT1(1) 9765792 68 52 68 20 22 22 4 11 9 0 0.55 1.00 1.00 439 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), CARS(8), DARS(1), EPRS(12), FARS2(2), HARS(2), IARS(3), KARS(2), LARS(1), LARS2(3), MARS(1), NARS(4), RARS(4), SARS(2), TARS(3), WARS(4), WARS2(2), YARS(1) 8566428 57 52 57 16 22 16 3 11 5 0 0.48 1.00 1.00 440 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(2), AZIN1(1), BTG1(1), CLDN5(1), CLOCK(5), CRY1(2), CRY2(2), EIF4G2(3), ETV6(4), GSTM3(1), GSTP1(1), HERPUD1(1), HSPA8(3), IDI1(1), KLF9(1), MYF6(1), NCKAP1(7), NR1D2(1), PER1(5), PER2(2), PIGF(1), PPP1R3C(2), PSMA4(1), PURA(1), SF3A3(2), TUBB3(2), UCP3(3), UGP2(4), VAPA(1), ZFR(5) 9847138 67 52 67 17 15 19 5 18 10 0 0.40 1.00 1.00 441 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(2), C1QB(2), C1R(3), C1S(3), C2(2), C3(5), C5(1), C6(18), C7(12), C8A(6), C8B(4), C9(3), MASP1(10) 5611094 71 52 71 24 17 26 7 13 8 0 0.68 1.00 1.00 442 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(5), ACY1(2), ADC(1), AGMAT(1), ALDH18A1(3), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), AMD1(1), AOC2(2), AOC3(3), ARG1(2), ASL(4), CPS1(27), GATM(1), NAGS(1), ODC1(1), OTC(3), SMS(2) 7925806 68 52 67 17 13 28 5 16 6 0 0.15 1.00 1.00 443 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP1(1), ARHGAP4(2), ARHGAP5(2), ARHGAP6(5), ARHGEF1(2), ARHGEF11(8), ARHGEF5(2), ARPC1A(4), BAIAP2(2), CFL1(2), DIAPH1(1), GSN(2), MYL2(2), MYLK(8), OPHN1(3), PIP5K1A(4), PIP5K1B(2), PPP1R12B(5), ROCK1(5), TLN1(6), VCL(2) 12227354 70 52 68 22 28 21 3 13 5 0 0.58 1.00 1.00 444 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(8), CREB1(1), CREB3(2), CREB5(3), DUSP4(2), DUSP6(2), DUSP9(2), EEF2K(5), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MKNK2(1), MOS(4), NFKB1(2), RAP1A(1), RPS6KA1(2), RPS6KA2(6), RPS6KA3(1), SHC1(2), SOS1(11), SOS2(7), TRAF3(3) 7935596 70 52 69 14 22 19 6 9 14 0 0.12 1.00 1.00 445 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACAA2(1), ACADL(2), ACADM(1), ACADS(2), ACAT1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH6A1(1), ALDH9A1(2), AOX1(13), BCAT1(1), BCKDHB(2), ECHS1(1), EHHADH(1), HADHA(2), HADHB(3), HIBADH(1), HMGCL(1), MCCC1(5), MCCC2(1), MCEE(1), MUT(4), OXCT1(3), PCCA(3), PCCB(6), SDS(2) 9621612 72 52 72 18 20 25 5 16 6 0 0.31 1.00 1.00 446 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(9), COL4A2(10), COL4A3(9), COL4A4(11), COL4A5(2), COL4A6(8), P4HB(4), SLC23A1(2), SLC23A2(2), SLC2A1(1), SLC2A3(5) 6856738 63 52 63 18 11 33 1 9 9 0 0.59 1.00 1.00 447 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), GUSB(2), UGDH(2), UGP2(4), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(3), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2), XYLB(1) 7360478 63 51 63 15 12 21 7 18 5 0 0.30 1.00 1.00 448 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(5), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOC3(3), DDC(4), EPX(4), ESCO1(2), ESCO2(1), GOT2(3), HPD(1), LPO(2), MPO(4), MYST3(11), MYST4(4), PNPLA3(1), PRDX6(2), SH3GLB1(1), TAT(1), TPO(10) 9147420 64 51 64 34 12 21 5 20 6 0 0.99 1.00 1.00 449 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12B(1), ALOX15(3), ALOX15B(1), CYP2B6(4), CYP2C18(2), CYP2C19(8), CYP2C8(2), CYP2C9(3), CYP2J2(1), CYP4A22(2), CYP4F2(3), CYP4F3(2), DHRS4(1), EPHX2(2), GGT1(1), GPX5(2), GPX6(2), LTA4H(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PTGES(1), PTGS1(2), TBXAS1(2) 10403032 70 51 70 31 23 21 9 9 8 0 0.88 1.00 1.00 450 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(9), CREBBP(17), CTNNB1(4), DVL1(3), EP300(9), FZD1(1), HDAC1(2), LEF1(3), PITX2(3), TRRAP(14), WNT1(1) 8883446 66 51 65 14 13 24 5 15 9 0 0.15 1.00 1.00 451 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(2), BAG4(1), CASP2(1), CASP8(2), CRADD(1), DFFB(2), FADD(1), JUN(3), LMNA(1), MADD(5), MAP2K4(1), MAP3K1(3), MAP3K7(2), MAPK8(2), PAK1(2), PAK2(1), PRKDC(12), RB1(12), SPTAN1(4), TNF(1), TNFRSF1A(2), TRADD(1) 10573200 62 51 61 23 15 18 0 11 18 0 0.86 1.00 1.00 452 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(10), CD3D(1), CD4(1), CREBBP(17), GNAS(6), GNB1(1), HLA-DRA(1), HLA-DRB1(2), LCK(3), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), PTPRC(7), ZAP70(4) 6161470 63 50 63 22 18 18 6 15 6 0 0.76 1.00 1.00 453 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(10), CD3D(1), CD4(1), CREBBP(17), GNAS(6), GNB1(1), HLA-DRA(1), HLA-DRB1(2), LCK(3), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), PTPRC(7), ZAP70(4) 6161470 63 50 63 22 18 18 6 15 6 0 0.76 1.00 1.00 454 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), AKR1B10(2), ALDOA(1), ALDOB(2), FBP2(1), FPGT(4), FUK(2), GMPPA(2), HK1(3), HK2(5), HK3(5), KHK(2), MPI(1), MTMR1(1), MTMR2(2), MTMR6(5), PFKFB1(4), PFKL(2), PFKM(5), PFKP(2), PGM2(4), PMM1(1), RDH11(1), RDH12(2), RDH13(1), SORD(1), TPI1(3) 10098652 65 50 65 22 14 24 5 14 8 0 0.54 1.00 1.00 455 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(2), CHIA(5), CHIT1(5), CMAS(2), CTBS(4), CYB5R1(1), GFPT1(1), GFPT2(3), GNE(2), GNPDA2(4), HEXA(5), HK1(3), HK2(5), HK3(5), MTMR1(1), MTMR2(2), MTMR6(5), NAGK(2), NPL(2), RENBP(2), UAP1(2) 7669842 63 50 63 17 10 28 3 11 11 0 0.36 1.00 1.00 456 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(6), AASDHPPT(1), AASS(11), ACAT1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), BBOX1(2), DLST(1), DOT1L(5), ECHS1(1), EHHADH(1), EHMT1(5), EHMT2(1), GCDH(2), HADHA(2), PLOD1(4), PLOD2(5), PLOD3(5), SDS(2), TMLHE(1) 9971382 70 50 70 30 13 25 7 16 9 0 0.92 1.00 1.00 457 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(9), BTRC(1), CCND1(1), CREBBP(17), CSNK1A1(2), CSNK1D(2), CSNK2A1(3), CTBP1(2), CTNNB1(4), DVL1(3), FZD1(1), HDAC1(2), MAP3K7(2), MYC(1), NLK(2), PPARD(2), TLE1(4), WIF1(5), WNT1(1) 7918330 64 50 64 14 19 22 6 9 8 0 0.19 1.00 1.00 458 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(8), CD2(1), CD33(3), CD5(2), CD7(1), IFNA1(1), IFNB1(2), IFNG(1), IL10(2), IL12A(1), IL12B(3), IL3(1), IL4(2), ITGAX(9), TLR2(3), TLR4(10), TLR7(3), TLR9(2) 4965488 55 49 54 19 10 23 3 13 6 0 0.56 1.00 1.00 459 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(3), ACACA(2), ACACB(9), ACADM(1), ACAT1(2), ACSS1(3), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH6A1(1), ALDH7A1(1), ALDH9A1(2), ECHS1(1), EHHADH(1), HADHA(2), HIBCH(1), LDHAL6A(2), LDHAL6B(1), LDHB(3), LDHC(3), MCEE(1), MLYCD(1), MUT(4), PCCA(3), PCCB(6), SUCLA2(2), SUCLG2(1) 10581032 62 49 62 21 20 18 4 11 9 0 0.70 1.00 1.00 460 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(3), DLAT(1), DLD(2), DLST(1), FH(2), IDH3A(1), IDH3B(4), IDH3G(2), MDH1(1), MDH2(1), OGDH(3), PC(2), PDHA1(3), PDHA2(8), PDHX(1), PDK1(1), PDK2(2), PDK3(3), PDK4(3), PDP2(4), SDHA(3), SDHB(2), SUCLA2(2), SUCLG2(1) 7571230 56 49 56 21 12 22 3 13 6 0 0.78 1.00 1.00 461 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(1), CFL1(2), GNAS(6), GNB1(1), HRAS(4), MAP2K1(2), MAPK1(1), MAPK3(1), MYL2(2), NOX1(2), PIK3C2G(8), PLCB1(8), PPP1R12B(5), PRKCA(5), PTK2(6), RAF1(1), ROCK2(3) 6814908 58 48 58 21 14 24 4 11 5 0 0.86 1.00 1.00 462 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN2(9), ACTN3(2), BCAR1(6), CTNNA1(1), CTNNA2(27), CTNNB1(4), PTK2(6), PXN(3), VCL(2) 5103438 62 48 62 29 17 27 3 11 4 0 0.95 1.00 1.00 463 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(2), ACP2(1), ACPT(1), ALPL(3), ALPP(3), ALPPL2(1), CYP19A1(4), CYP1A1(7), CYP1A2(1), CYP2A13(1), CYP2A6(5), CYP2A7(1), CYP2B6(4), CYP2C18(2), CYP2C19(8), CYP2C8(2), CYP2C9(3), CYP2D6(3), CYP2F1(3), CYP2J2(1), CYP3A4(1), CYP3A7(1), CYP4B1(3), CYP4F8(3), PON1(6) 7861014 70 48 70 32 21 20 6 19 4 0 0.93 1.00 1.00 464 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(4), AKT1(1), ANXA1(1), CALM2(1), GNAS(6), GNB1(1), NFKB1(2), NOS3(2), NR3C1(1), PIK3CA(29), PIK3R1(2), RELA(3), SYT1(4) 4775028 57 48 44 13 30 10 4 10 3 0 0.31 1.00 1.00 465 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAA2(1), ACAD8(2), ACAD9(3), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), AKR1B10(2), AKR1C4(1), AKR1D1(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(1), CYP7A1(5), HADHB(3), LIPA(2), RDH11(1), RDH12(2), RDH13(1), SLC27A5(4), SOAT1(1), SOAT2(2), SRD5A1(2), SRD5A2(2) 8497542 62 48 62 19 15 24 0 15 8 0 0.38 1.00 1.00 466 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10B(1), ALG12(1), ALG13(8), ALG2(3), ALG5(2), ALG6(2), ALG8(1), ALG9(1), B4GALT1(1), B4GALT3(3), DDOST(1), DPM1(1), FUT8(2), GANAB(5), MAN1A1(4), MAN1A2(5), MAN1C1(3), MAN2A1(4), MGAT1(2), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(5), MGAT5B(4), RPN1(1), ST6GAL1(2), STT3B(1) 11411046 73 48 73 28 29 26 2 9 7 0 0.78 1.00 1.00 467 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(13), BST1(1), C9orf95(1), CD38(2), ENPP1(8), ENPP3(6), NADK(1), NADSYN1(7), NMNAT2(2), NMNAT3(1), NNT(10), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5C3(3), NT5E(2), NUDT12(2) 5777880 66 48 66 16 19 25 3 11 8 0 0.22 1.00 1.00 468 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX15(3), CYP4F2(3), CYP4F3(2), EPX(4), GGT1(1), LPO(2), LTA4H(2), MPO(4), PLA2G2A(1), PLA2G2E(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PRDX1(1), PRDX6(2), PTGS1(2), TBXAS1(2), TPO(10) 7417794 59 48 59 28 13 21 9 11 5 0 0.93 1.00 1.00 469 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(6), CALM2(1), CRKL(1), HRAS(4), JUN(3), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), PAK1(2), PLCG1(3), PRKCA(5), RAC1(1), RAF1(1), SHC1(2), SOS1(11), SYT1(4) 7603448 59 48 58 20 16 20 5 14 4 0 0.73 1.00 1.00 470 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(2), CHUK(2), FOS(2), IKBKB(2), IRAK1(3), JUN(3), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP3K1(3), MAP3K14(1), MAP3K7(2), MAPK14(1), MAPK8(2), NFKB1(2), PPARA(1), RELA(3), TLR2(3), TLR3(2), TLR4(10), TLR7(3), TLR9(2), TOLLIP(1), TRAF6(5) 9740516 61 48 60 28 18 20 5 9 9 0 0.96 1.00 1.00 471 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), ABAT(3), ADSL(1), ADSS(1), AGXT(2), AGXT2(2), ASL(4), ASNS(5), CAD(10), DARS(1), DDO(2), GAD1(5), GAD2(6), GOT2(3), GPT(1), GPT2(4), NARS(4), PC(2) 6992018 58 47 58 21 17 19 2 14 6 0 0.66 1.00 1.00 472 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(3), ABP1(5), ACADL(2), ACADM(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), AOC2(2), AOC3(3), CNDP1(3), DPYD(8), DPYS(6), ECHS1(1), EHHADH(1), GAD1(5), GAD2(6), HADHA(2), MLYCD(1), SDS(2), SMS(2) 7762936 65 47 65 25 14 26 4 13 8 0 0.78 1.00 1.00 473 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(3), CDC42(1), CREB1(1), DAXX(3), HRAS(4), HSPB2(1), MAP2K4(1), MAP2K6(2), MAP3K1(3), MAP3K5(4), MAP3K7(2), MAP3K9(4), MAPK14(1), MAPKAPK2(2), MAPKAPK5(3), MEF2A(3), MEF2C(4), MEF2D(3), MYC(1), PLA2G4A(7), RAC1(1), RPS6KA5(4), SHC1(2), STAT1(2), TGFB1(1), TGFB2(3), TRADD(1) 9851766 67 46 67 26 20 26 4 11 6 0 0.90 1.00 1.00 474 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), CDC42(1), CREB1(1), CREB3(2), CREB5(3), DUSP10(4), EEF2K(5), GADD45A(1), IL1R1(1), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP3K4(4), MAP3K5(4), MAP3K7(2), MAPK1(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPKAPK2(2), MAPKAPK5(3), MKNK2(1), MYEF2(4), NFKB1(2), NR2C2(3), SRF(2), TRAF6(5) 8899644 63 46 63 23 23 21 4 6 9 0 0.80 1.00 1.00 475 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(2), CAMK2D(1), DAG1(2), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(13), ITPR3(4), NFAT5(3), PDE6A(3), PDE6B(3), PDE6C(1), PDE6H(2), SLC6A13(5), TF(6) 9665934 59 46 58 21 16 22 3 8 10 0 0.64 1.00 1.00 476 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(2), CP(2), CPOX(2), EPRS(12), FECH(2), GUSB(2), HCCS(1), PPOX(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2B15(3), UGT2B4(8), UROD(1), UROS(1) 7334134 55 45 55 16 12 23 5 12 3 0 0.48 1.00 1.00 477 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(5), AGT(1), AGTR2(3), EDNRA(1), EDNRB(5), EGF(6), EGFR(7), FOS(2), HRAS(4), JUN(3), MYC(1), NFKB1(2), PLCG1(3), PRKCA(5), RELA(3) 5460684 51 44 49 16 13 18 3 8 9 0 0.51 1.00 1.00 478 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(3), ABP1(5), ACADM(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), AOC2(2), AOC3(3), CNDP1(3), DPYD(8), DPYS(6), ECHS1(1), EHHADH(1), GAD1(5), GAD2(6), HADHA(2), HIBCH(1), MLYCD(1), SMS(2) 7226978 59 44 59 24 13 23 3 12 8 0 0.83 1.00 1.00 479 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(3), GNS(1), GUSB(2), HEXA(5), HGSNAT(1), HPSE(3), HPSE2(2), HYAL1(3), IDS(1), IDUA(2), LCT(18), SPAM1(6) 5481154 48 44 48 17 12 15 2 12 7 0 0.66 1.00 1.00 480 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(17), EP300(9), IKBKB(2), IL1B(1), MAP2K3(3), MAP2K6(2), MAP3K14(1), MAP3K7(2), MAPK11(2), MAPK14(1), NFKB1(2), NR3C1(1), RELA(3), TGFBR2(3), TLR2(3), TNF(1) 7910142 55 44 54 17 11 18 3 12 11 0 0.60 1.00 1.00 481 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(3), CHAT(9), DBH(1), DDC(4), GAD1(5), GAD2(6), HDC(6), PAH(3), PNMT(2), SLC18A3(8), TH(1), TPH1(2) 3884494 50 43 50 18 13 22 4 9 2 0 0.54 1.00 1.00 482 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(2), C1QB(2), C1R(3), C1S(3), C2(2), C3(5), C5(1), C6(18), C7(12), C8A(6), C9(3) 4733020 57 43 57 18 13 20 7 9 8 0 0.61 1.00 1.00 483 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(3), EPHA4(1), EPHB1(13), FYN(5), ITGA1(4), ITGB1(5), L1CAM(2), LYN(2), RAP1B(1), SELP(11) 4202046 47 43 47 24 6 19 3 10 9 0 0.99 1.00 1.00 484 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(3), ACACA(2), ACADL(2), ACADM(1), ACAT1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH6A1(1), ALDH9A1(2), ECHS1(1), EHHADH(1), HADHA(2), LDHB(3), LDHC(3), MCEE(1), MLYCD(1), MUT(4), PCCA(3), PCCB(6), SDS(2), SUCLA2(2), SUCLG2(1) 8818654 53 43 53 15 15 18 4 9 7 0 0.52 1.00 1.00 485 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(7), DLG4(1), EPHB2(5), F2RL1(3), F2RL2(1), F2RL3(1), JUN(3), MAP2K5(1), MAPK1(1), MAPK7(1), MAPK8(2), MYEF2(4), PLD1(7), PLD2(2), PLD3(1), PTK2(6), RAF1(1), RASAL1(7), TEC(4), VAV1(7) 7362258 65 43 64 23 21 24 4 10 6 0 0.67 1.00 1.00 486 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), CHUK(2), EGR2(6), EGR3(2), MAP3K1(3), MYC(1), NFATC1(3), NFATC2(4), NFKB1(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), RELA(3), SYT1(4), VIP(1), VIPR2(3) 7456242 58 43 58 18 15 22 5 9 7 0 0.52 1.00 1.00 487 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(3), ACADS(2), ACAT1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH5A1(1), ALDH9A1(2), ECHS1(1), EHHADH(1), GAD1(5), GAD2(6), HADHA(2), HMGCL(1), OXCT1(3), PDHA1(3), PDHA2(8), SDHB(2), SDS(2) 6870978 55 42 55 25 13 24 3 8 7 0 0.93 1.00 1.00 488 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), CSF1R(3), E2F1(2), ETS1(2), ETV3(2), FOS(2), HDAC5(1), HRAS(4), JUN(3), NCOR2(6), RBL1(5), RBL2(7), SIN3A(5), SIN3B(3) 6956596 47 42 46 12 17 16 3 7 4 0 0.31 1.00 1.00 489 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX15(3), CYP1A2(1), CYP2C18(2), CYP2C19(8), CYP2C8(2), CYP2C9(3), CYP2J2(1), CYP3A4(1), CYP3A43(4), CYP3A7(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), RDH11(1), RDH12(2), RDH13(1) 6391802 54 42 54 15 20 16 6 5 7 0 0.28 1.00 1.00 490 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), CYP2C19(8), CYP2C9(3), DHRS2(2), DHRSX(4), ECHS1(1), EHHADH(1), ESCO1(2), ESCO2(1), HADHA(2), MYST3(11), MYST4(4), PNPLA3(1), SH3GLB1(1) 8260980 51 42 51 23 15 17 0 10 9 0 0.94 1.00 1.00 491 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(5), ABCC2(6), ABCG2(2), BCHE(13), CES1(2), CES2(1), CYP3A4(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3) 6078700 48 42 48 13 9 21 3 13 2 0 0.29 1.00 1.00 492 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(3), ADCY1(10), CAP1(2), CCNB1(2), CDC25C(1), GNAI1(3), GNAS(6), GNB1(1), HRAS(4), MAPK1(1), MAPK3(1), MYT1(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), RPS6KA1(2) 5464956 50 42 50 19 12 15 6 13 4 0 0.84 1.00 1.00 493 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(17), EP300(9), LPL(3), NCOA1(6), NCOA2(12), RXRA(2) 4945908 49 42 48 16 10 18 3 11 7 0 0.73 1.00 1.00 494 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(9), CDH1(3), CREBBP(17), EP300(9), MAP2K1(2), MAP3K7(2), MAPK3(1), SKIL(1), TGFB1(1), TGFB2(3), TGFBR2(3) 6832352 51 42 50 14 13 16 2 13 7 0 0.55 1.00 1.00 495 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(3), ACTN1(2), ACTN2(9), ACTN3(2), CAPN1(2), CAPNS2(1), ITGA1(4), ITGB1(5), ITGB3(4), PTK2(6), PXN(3), RAC1(1), SPTAN1(4), TLN1(6) 7632284 52 42 52 21 13 17 2 14 6 0 0.87 1.00 1.00 496 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(2), FBP2(1), GOT2(3), GPT(1), GPT2(4), MDH1(1), MDH2(1), ME1(2), ME3(2), PGK1(2), PGK2(4), PKLR(4), PKM2(3), RPIA(2), TKT(1), TKTL2(11), TPI1(3) 5357444 48 41 48 20 8 18 6 9 7 0 0.81 1.00 1.00 497 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(2), CD3D(1), CXCR3(1), ETV5(1), IFNG(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL18R1(2), JAK2(4), JUN(3), MAP2K6(2), MAPK14(1), MAPK8(2), STAT4(5), TYK2(8) 4982220 44 41 43 12 14 17 2 4 7 0 0.47 1.00 1.00 498 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IFNA1(1), IFNB1(2), IKBKB(2), IL1A(1), IL1B(1), IL1R1(1), IL1RAP(2), IL6(1), IRAK1(3), IRAK2(1), IRAK3(4), JUN(3), MAP2K3(3), MAP2K6(2), MAP3K1(3), MAP3K14(1), MAP3K7(2), MAPK14(1), MAPK8(2), NFKB1(2), RELA(3), TGFB1(1), TGFB2(3), TNF(1), TOLLIP(1), TRAF6(5) 7908896 54 41 53 18 17 19 3 9 6 0 0.66 1.00 1.00 499 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2R(2), F2RL3(1), GNAI1(3), GNB1(1), HRAS(4), ITGA1(4), ITGB1(5), MAP2K1(2), MAPK1(1), MAPK3(1), PLA2G4A(7), PLCB1(8), PRKCA(5), PTGS1(2), PTK2(6), RAF1(1), SYK(1), TBXAS1(2) 6511952 56 41 56 20 14 19 5 13 5 0 0.81 1.00 1.00 500 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(2), ARSB(1), ARSD(1), ARSE(2), GAL3ST1(1), GALC(2), GBA(4), GLA(2), LCT(18), NEU1(2), NEU2(2), NEU4(2), PPAP2B(2), SMPD1(4), SMPD2(1), SPTLC1(1), SPTLC2(3), UGCG(1) 6530820 51 40 51 19 14 18 3 12 4 0 0.69 1.00 1.00 501 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(5), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH9A1(2), AOC2(2), AOC3(3), CNDP1(3), DDC(4), HAL(2), HARS(2), HDC(6), HNMT(3), PRPS1(2), PRPS2(1) 6561080 46 40 46 23 6 24 3 11 2 0 0.92 1.00 1.00 502 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(2), DERA(1), FBP2(1), G6PD(1), GPI(5), H6PD(2), PFKL(2), PFKM(5), PFKP(2), PGD(1), PGM1(1), PRPS1(2), PRPS1L1(3), PRPS2(1), RBKS(1), RPIA(2), TALDO1(1), TKT(1), TKTL2(11) 6533490 46 40 46 17 4 18 6 9 9 0 0.67 1.00 1.00 503 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(3), ABP1(5), AOC2(2), AOC3(3), CES1(2), CES7(2), DDHD1(5), ESCO1(2), ESCO2(1), LIPA(2), MYST3(11), MYST4(4), PLA1A(5), PNPLA3(1), PRDX6(2), SH3GLB1(1) 6769874 51 40 51 22 12 16 1 17 5 0 0.93 1.00 1.00 504 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(2), FADD(1), IKBKB(2), IL1A(1), IL1R1(1), IRAK1(3), MAP3K1(3), MAP3K14(1), MAP3K7(2), NFKB1(2), RELA(3), TLR4(10), TNF(1), TNFAIP3(5), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(5) 6534736 46 40 46 19 10 17 6 6 7 0 0.90 1.00 1.00 505 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(5), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOC3(3), DDC(4), EPX(4), GOT2(3), HPD(1), LPO(2), MPO(4), PRDX1(1), PRDX6(2), TAT(1), TPO(10) 5880764 45 40 45 25 7 17 6 14 1 0 0.98 1.00 1.00 506 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(9), APOA4(3), APOC2(2), APOC3(2), CYP7A1(5), DGAT1(1), HMGCR(1), LDLR(4), LIPC(2), LPL(3), LRP1(15), SCARB1(3), SOAT1(1) 7302094 51 40 51 22 17 18 1 10 5 0 0.82 1.00 1.00 507 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), CDK5R1(1), CSNK1D(2), DRD1(1), DRD2(4), GRM1(12), PLCB1(8), PPP1R1B(1), PPP3CA(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2) 4313296 44 39 44 14 12 17 4 7 4 0 0.51 1.00 1.00 508 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(1), EXTL1(3), EXTL2(1), EXTL3(1), HS3ST2(2), HS3ST3A1(1), HS3ST5(4), HS6ST1(5), HS6ST3(3), NDST1(4), NDST2(2), NDST3(4), NDST4(13) 5560542 46 39 46 17 13 16 5 8 4 0 0.67 1.00 1.00 509 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(3), FOS(2), HRAS(4), IL2RB(2), IL2RG(1), JAK1(2), JAK3(7), JUN(3), LCK(3), MAP2K1(2), MAPK3(1), MAPK8(2), RAF1(1), SHC1(2), SOS1(11), STAT5A(2), SYK(1) 6284646 49 39 48 13 14 16 3 11 5 0 0.36 1.00 1.00 510 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(9), CERK(6), CREB1(1), CREB3(2), CREB5(3), DAG1(2), EPHB2(5), FOS(2), ITPKA(1), ITPKB(6), JUN(3), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK8(2), MAPK8IP1(2), MAPK8IP3(3), MAPK9(1) 7663434 52 39 51 18 20 17 4 4 7 0 0.70 1.00 1.00 511 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2R(2), F3(1), F5(19), F7(2), FGA(5), FGB(4), FGG(2), PROS1(5), SERPINC1(7) 4372214 50 38 50 12 18 14 6 9 3 0 0.36 1.00 1.00 512 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOA(1), ALDOB(2), FBP2(1), FPGT(4), GCK(5), GMPPA(2), HK1(3), HK2(5), HK3(5), KHK(2), MPI(1), PFKFB1(4), PFKM(5), PFKP(2), PMM1(1), SORD(1), TPI1(3) 6462824 48 38 48 18 14 20 2 8 4 0 0.59 1.00 1.00 513 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACO1(2), ACO2(3), CLYBL(1), DLD(2), DLST(1), FH(2), IDH1(2), IDH3A(1), IDH3B(4), IDH3G(2), MDH1(1), MDH2(1), OGDH(3), OGDHL(6), PC(2), PCK1(2), PCK2(1), SDHA(3), SDHB(2), SUCLA2(2), SUCLG2(1) 7932036 44 38 44 25 9 18 1 10 6 0 0.99 1.00 1.00 514 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(3), FUCA1(2), FUCA2(1), HEXA(5), LCT(18), MAN2B1(2), MAN2B2(3), MAN2C1(6), MANBA(2), NEU1(2), NEU2(2), NEU4(2) 5495928 48 38 48 15 12 14 4 14 4 0 0.47 1.00 1.00 515 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(1), ANXA4(1), ANXA5(3), ANXA6(4), CYP11A1(2), EDNRA(1), EDNRB(5), HSD11B1(3), HSD11B2(1), PLA2G4A(7), PRL(1), PTGDR(5), PTGER2(2), PTGER4(2), PTGFR(5), PTGIR(1), PTGS1(2), TBXAS1(2) 5530816 48 38 48 18 8 18 4 9 9 0 0.74 1.00 1.00 516 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2A1(1), GTF2B(2), GTF2E1(2), GTF2F1(1), HDAC3(1), NCOA1(6), NCOA2(12), NCOA3(4), NCOR2(6), POLR2A(2), RARA(1), RXRA(2), TBP(1) 6661294 42 38 42 20 8 17 2 8 7 0 0.96 1.00 1.00 517 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(5), C5(1), C6(18), C7(12), C8A(6), C9(3) 3391968 45 37 45 14 8 17 7 7 6 0 0.67 1.00 1.00 518 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ACAA2(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(4), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(1), CYP7A1(5), HADHB(3), SOAT2(2), SRD5A1(2), SRD5A2(2) 6210064 46 37 46 14 11 19 0 11 5 0 0.44 1.00 1.00 519 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(10), CREM(2), FHL5(3), FSHB(2), FSHR(15), GNAS(6), XPO1(2) 2536856 40 37 40 15 11 10 4 13 2 0 0.88 1.00 1.00 520 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), HEXA(5), LCT(18), SLC33A1(3), ST3GAL1(4), ST3GAL5(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(3), ST8SIA1(3) 4389658 45 37 45 15 13 19 2 6 5 0 0.42 1.00 1.00 521 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CALM2(1), CAPN2(2), CAPNS2(1), EP300(9), HDAC1(2), MEF2D(3), NFATC1(3), NFATC2(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(5), SYT1(4) 6502340 49 37 48 13 15 16 5 6 7 0 0.42 1.00 1.00 522 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(2), AP2M1(1), ARF1(1), BTK(7), EEA1(3), GRASP(1), GSK3A(3), LYN(2), PDPK1(1), PFKL(2), PFKM(5), PFKP(2), PLCG1(3), PRKCE(3), PRKCZ(1), RAC1(1), RPS6KB1(1), VAV2(4) 6673220 44 37 44 19 8 13 7 7 9 0 0.92 1.00 1.00 523 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREB1(1), CREBBP(17), EP300(9), NCOA3(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), RARA(1), RXRA(2) 5543098 45 36 44 12 9 16 2 13 5 0 0.44 1.00 1.00 524 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(3), CSF1R(3), EGF(6), EGFR(7), MET(4), PDGFRA(10), PRKCA(5), SH3GLB1(1), SH3KBP1(4) 5179266 43 36 42 14 13 15 4 5 6 0 0.65 1.00 1.00 525 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(2), BAIAP2(2), CASP1(1), CASP7(2), CASP8(2), GAPDH(2), INSR(9), ITCH(2), MAGI1(7), MAGI2(12), RERE(3), WWP1(3), WWP2(2) 6437904 49 36 49 18 10 16 2 12 9 0 0.82 1.00 1.00 526 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(2), CCR1(3), CCR2(1), CCR3(1), CCR4(3), CCR5(2), CD4(1), CXCR3(1), CXCR4(5), IFNG(1), IFNGR1(4), IFNGR2(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL18R1(2), IL4(2), IL4R(2), TGFB1(1), TGFB2(3) 5338042 46 36 46 19 12 14 1 10 9 0 0.83 1.00 1.00 527 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(10), ADRB2(4), GNAS(6), PLCE1(13), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2) 3927214 43 36 42 13 12 15 3 9 4 0 0.56 1.00 1.00 528 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CDK7(1), ERCC3(1), GTF2B(2), GTF2E1(2), GTF2H1(2), GTF2H4(2), ILK(1), POLR1A(3), POLR1B(2), POLR2A(2), POLR2B(6), POLR2E(2), POLR3B(2), POLR3D(2), POLR3E(4), POLR3H(2), TAF5(1), TAF9(2), TBP(1) 9353188 40 36 40 19 12 13 2 5 8 0 0.95 1.00 1.00 529 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(3), CR1(7), CR2(11), FCGR2B(3), HLA-DRA(1), HLA-DRB1(2), ICAM1(2), ITGAL(1), ITGB2(5), PTPRC(7) 4110198 42 35 42 14 15 12 2 10 3 0 0.67 1.00 1.00 530 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM2(1), CDKN1A(2), MARCKS(1), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(5), SP1(2), SP3(1), SYT1(4) 5587776 44 35 44 12 14 19 3 4 4 0 0.43 1.00 1.00 531 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CARM1(1), CBS(4), GGT1(1), LCMT1(2), LCMT2(2), MARS(1), MAT1A(1), METTL2B(1), METTL6(2), PAPSS2(1), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), SCLY(1), SEPHS1(3), WBSCR22(3) 6665566 42 35 42 11 11 17 2 2 10 0 0.26 1.00 1.00 532 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT3(1), AGPAT4(1), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(7), ENPP6(3), PAFAH1B1(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLD1(7), PLD2(2), PPAP2B(2) 6221634 49 35 49 22 12 20 5 6 6 0 0.91 1.00 1.00 533 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(6), DYRK1B(3), GLI2(6), GLI3(9), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2), SHH(2), SMO(1), SUFU(2) 4514792 39 35 39 15 13 14 4 5 3 0 0.72 1.00 1.00 534 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(4), BIRC2(1), BIRC3(3), CASP10(3), CASP7(2), CASP8(2), CASP9(3), CFLAR(1), CHUK(2), DFFB(2), FADD(1), GAS2(3), LMNA(1), MAP3K14(1), NFKB1(2), RELA(3), SPTAN1(4), TNFRSF10A(1), TNFRSF10B(1), TRADD(1) 9001816 41 34 40 17 12 7 3 11 8 0 0.89 1.00 1.00 535 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(2), ACAD9(3), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), DHRS2(2), DHRSX(4), ESCO1(2), ESCO2(1), MYST3(11), MYST4(4), PNPLA3(1), SH3GLB1(1) 6688528 41 34 41 17 13 13 0 8 7 0 0.88 1.00 1.00 536 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(3), FUCA1(2), FUCA2(1), HEXA(5), LCT(18), MAN2C1(6), MANBA(2), NEU1(2), NEU2(2), NEU4(2) 4461392 43 34 43 13 10 13 3 13 4 0 0.47 1.00 1.00 537 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT10(2), GALNT2(2), GALNT3(3), GALNT6(2), GALNT8(3), GALNT9(1), GCNT1(3), ST3GAL1(4), ST3GAL4(2), WBSCR17(11) 3849606 35 34 34 14 6 14 6 5 4 0 0.81 1.00 1.00 538 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(2), FBP2(1), G6PD(1), GPI(5), H6PD(2), PFKM(5), PFKP(2), PGD(1), PGM1(1), PRPS1(2), PRPS1L1(3), PRPS2(1), RBKS(1), RPIA(2), TAL1(4), TALDO1(1), TKT(1) 5480086 36 34 36 15 4 12 4 7 9 0 0.78 1.00 1.00 539 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(9), BTRC(1), CTNNB1(4), DLL1(1), DVL1(3), FZD1(1), NOTCH1(16), PSEN1(3), WNT1(1) 5774142 39 34 39 12 8 13 1 6 11 0 0.60 1.00 1.00 540 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(2), FBP2(1), GOT2(3), GPT(1), GPT2(4), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(2), PGK1(2), PKLR(4), PKM2(3), RPIA(2), TKT(1), TPI1(3) 4793006 36 33 36 16 8 12 2 7 7 0 0.83 1.00 1.00 541 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), KHK(2), LCT(18), MPI(1), PGM1(1), PYGL(3), PYGM(6), TPI1(3), TREH(1) 3585632 38 33 38 12 8 15 2 7 6 0 0.38 1.00 1.00 542 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACOT11(1), DHRS2(2), DHRSX(4), ECHS1(1), EHHADH(1), ESCO1(2), ESCO2(1), FN3K(1), GCDH(2), HADHA(2), MYST3(11), MYST4(4), PNPLA3(1), SH3GLB1(1) 6937728 36 33 36 18 10 9 1 9 7 0 0.97 1.00 1.00 543 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(2), ACP2(1), ACP6(2), ACPT(1), ENPP1(8), ENPP3(6), FLAD1(2), MTMR1(1), MTMR2(2), MTMR6(5), TYR(10) 4036684 40 33 40 11 5 18 4 4 9 0 0.47 1.00 1.00 544 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(2), CD2(1), CD3D(1), CD4(1), CXCR3(1), IFNG(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), JAK2(4), STAT4(5), TYK2(8) 3935402 35 33 35 10 8 12 2 5 8 0 0.53 1.00 1.00 545 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), CDK5R1(1), DAB1(6), FYN(5), LRP8(1), RELN(33) 3756512 47 33 47 14 14 12 6 12 3 0 0.64 1.00 1.00 546 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(2), HRAS(4), JUN(3), MAP2K1(2), MAPK1(1), MAPK3(1), MYC(1), NFKB1(2), PLCB1(8), PRKCA(5), RAF1(1), RELA(3), TNF(1) 4118386 36 32 35 11 12 12 4 6 2 0 0.55 1.00 1.00 547 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(10), GNAS(6), GNB1(1), PRKAA2(5), PRKAB2(1), PRKACB(3), PRKACG(1), PRKAG2(4), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2) 4090796 37 32 37 11 10 12 5 6 4 0 0.60 1.00 1.00 548 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), BCAT2(2), COASY(2), DPYD(8), DPYS(6), ENPP1(8), ENPP3(6), ILVBL(2), PANK1(1), PANK2(1), PANK3(1), PANK4(1), PPCS(1), VNN1(2) 4617676 42 32 42 14 10 15 4 4 9 0 0.65 1.00 1.00 549 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(1), BIRC3(3), CASP8(2), CFLAR(1), FADD(1), JUN(3), MAP2K4(1), MAP3K3(1), MAP3K7(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(4), NR2C2(3), RALBP1(1), TNF(1), TNFAIP3(5), TNFRSF1A(2), TNFRSF1B(1), TRADD(1) 7285184 42 32 41 17 14 18 2 3 5 0 0.81 1.00 1.00 550 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(2), IKBKAP(4), IKBKB(2), LTA(2), MAP3K1(3), MAP3K14(1), NFKB1(2), RELA(3), TANK(4), TNFAIP3(5), TNFRSF1B(1), TRAF1(4), TRAF3(3) 5986140 36 32 36 10 3 10 3 11 9 0 0.54 1.00 1.00 551 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(10), ADRB2(4), CFTR(8), GNAS(6), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2) 3481324 38 31 38 11 13 12 3 7 3 0 0.50 1.00 1.00 552 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(3), GNS(1), GUSB(2), HEXA(5), IDS(1), IDUA(2), LCT(18) 3828068 33 31 33 12 10 12 1 5 5 0 0.60 1.00 1.00 553 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(2), ARHGEF1(2), GNA12(2), GNA13(1), GNB1(1), MYL2(2), MYLK(8), PLCB1(8), PPP1R12B(5), PRKCA(5), ROCK1(5) 5541852 41 31 41 11 15 14 3 6 3 0 0.51 1.00 1.00 554 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2D(1), CAMK4(3), HDAC5(1), MEF2A(3), MEF2C(4), MEF2D(3), PPARA(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), SLC2A4(2), SYT1(4) 5469406 39 31 39 13 11 15 4 4 5 0 0.61 1.00 1.00 555 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(2), ACO2(3), DLD(2), DLST(1), FH(2), IDH1(2), IDH3A(1), IDH3B(4), IDH3G(2), MDH1(1), MDH2(1), PC(2), PCK1(2), SDHA(3), SDHB(2), SUCLA2(2), SUCLG2(1) 5468516 33 30 33 13 8 13 1 6 5 0 0.77 1.00 1.00 556 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(1), BHMT(2), CBS(4), DNMT1(4), DNMT3A(7), DNMT3B(4), MARS(1), MAT1A(1), MTAP(1), MTR(7), TAT(1) 5590268 34 30 34 13 11 11 1 7 4 0 0.75 1.00 1.00 557 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT2(1), B3GNT3(4), B3GNT4(1), B4GALT1(1), B4GALT3(3), B4GALT4(3), FUT2(1), FUT3(3), FUT5(4), FUT6(2), FUT9(5), GCNT2(2), ST3GAL6(2), ST8SIA1(3) 4307422 36 30 36 13 7 17 5 5 2 0 0.59 1.00 1.00 558 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(5), ATIC(1), FTCD(3), GART(3), MTHFD1(4), MTHFD1L(2), MTHFD2(4), MTHFR(2), MTR(7) 5085460 31 29 31 10 13 9 2 4 3 0 0.56 1.00 1.00 559 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CASP2(1), CHUK(2), CRADD(1), IKBKB(2), JUN(3), LTA(2), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP3K1(3), MAP3K14(1), MAP4K2(1), MAPK14(1), MAPK8(2), NFKB1(2), RELA(3), TANK(4), TNF(1), TNFRSF1A(2), TRADD(1) 6481158 38 29 37 16 9 11 2 8 8 0 0.86 1.00 1.00 560 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(2), ACP2(1), ACP6(2), ACPT(1), ALPL(3), ALPP(3), ALPPL2(1), CMBL(3), CYP3A4(1), CYP3A43(4), CYP3A7(1), DHRS2(2), DHRSX(4), PON1(6), PON2(1), PON3(1) 4831988 36 28 36 15 10 12 3 7 4 0 0.79 1.00 1.00 561 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(4), BIRC2(1), BIRC3(3), CASP10(3), CASP7(2), CASP8(2), CASP9(3), DFFB(2), GZMB(1), PRF1(2), SCAP(4), SREBF1(2), SREBF2(3) 4901230 32 28 31 12 10 7 2 9 4 0 0.76 1.00 1.00 562 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(6), EGFR(7), MAP2K1(2), MAP3K1(3), MAPK14(1), NCOR2(6), RARA(1), RXRA(2), THRA(1), THRB(2) 4603436 31 27 30 13 6 13 0 9 3 0 0.83 1.00 1.00 563 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(2), IL22(2), IL22RA2(1), JAK1(2), JAK2(4), JAK3(7), SOCS3(1), STAT1(2), STAT3(2), STAT5A(2), TYK2(8) 4962106 33 27 33 10 9 13 2 4 5 0 0.37 1.00 1.00 564 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(2), CBS(4), DNMT1(4), DNMT3A(7), DNMT3B(4), MARS(1), MAT1A(1), MTR(7) 4679264 31 27 31 12 9 11 1 7 3 0 0.75 1.00 1.00 565 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(2), ESR1(6), GREB1(13), HSPB2(1), MTA1(1), MTA3(2), TUBA8(1) 2941094 27 27 27 13 3 12 2 9 1 0 0.89 1.00 1.00 566 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(2), B4GALT1(1), B4GALT3(3), B4GALT5(2), DDOST(1), DPM1(1), FUT8(2), MAN1A1(4), MGAT1(2), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(5), RPN1(1), ST6GAL1(2) 5334838 35 27 35 17 12 15 2 4 2 0 0.89 1.00 1.00 567 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(5), ATIC(1), GART(3), MTHFD1(4), MTHFD1L(2), MTHFD2(4), MTHFR(2), MTR(7) 4793184 28 27 28 10 13 8 1 4 2 0 0.65 1.00 1.00 568 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(2), DPYD(8), DPYS(6), ENPP1(8), ENPP3(6), PANK1(1), PANK2(1), PANK3(1), PANK4(1), PPCS(1) 3726786 36 27 36 13 9 12 3 3 9 0 0.78 1.00 1.00 569 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(6), ESR2(2), ITPKA(1), PDE1A(2), PDE1B(3), PLCB1(8), PLCB2(5), PRL(1), VIP(1) 2974380 29 27 29 14 8 14 0 6 1 0 0.93 1.00 1.00 570 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(4), ARHGDIB(2), BIRC2(1), BIRC3(3), CASP1(1), CASP10(3), CASP2(1), CASP4(4), CASP7(2), CASP8(2), CASP9(3), DFFB(2), GZMB(1), LMNA(1), PRF1(2) 5193684 32 26 31 12 9 7 1 8 7 0 0.84 1.00 1.00 571 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), BCAT2(2), IARS(3), IARS2(3), ILVBL(2), LARS(1), LARS2(3), PDHA1(3), PDHA2(8), VARS(4), VARS2(1) 4937186 31 26 31 10 7 13 2 6 3 0 0.60 1.00 1.00 572 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(4), AGT(1), AGTR1(5), AGTR2(3), BDKRB2(3), KNG1(9), NOS3(2) 2684062 27 25 27 10 5 12 2 4 4 0 0.61 1.00 1.00 573 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(11), MAP2(9), PRKACB(3), PRKACG(1), PRKAR2B(2), PRKCE(3) 4865096 29 25 29 10 8 10 2 5 4 0 0.85 1.00 1.00 574 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CCR5(2), CXCR4(5), FOS(2), JUN(3), MAPK14(1), MAPK8(2), PLCG1(3), PRKCA(5), SYT1(4) 3663418 28 25 27 11 11 9 3 3 2 0 0.77 1.00 1.00 575 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(6), IL4(2), MAF(1), MAP2K3(3), MAPK14(1), NFATC1(3), NFATC2(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2) 3267546 30 25 30 15 7 13 2 4 4 0 0.89 1.00 1.00 576 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(3), GPLD1(1), PGAP1(4), PIGB(1), PIGF(1), PIGG(4), PIGH(1), PIGK(1), PIGL(2), PIGN(1), PIGO(2), PIGQ(1), PIGT(1), PIGW(2), PIGX(1), PIGZ(2) 6416188 28 25 28 18 5 11 3 4 5 0 0.98 1.00 1.00 577 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 RPL10L(7), RPL13(1), RPL14(1), RPL19(1), RPL32(1), RPL37(1), RPL3L(2), RPL7(1), RPL8(2), RPS11(1), RPS12(1), RPS18(1), RPS2(1), RPS20(1), RPS21(1), RPS26(1), RPS6(1), RPS8(1) 6192086 26 25 26 14 10 7 0 7 2 0 0.92 1.00 1.00 578 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1G(3), HDAC9(16), MEF2A(3), MEF2C(4), MEF2D(3), MYOD1(1) 2163056 30 25 30 10 9 13 1 5 2 0 0.62 1.00 1.00 579 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), CASP8(2), FADD(1), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(2), NSMAF(4), RAF1(1), RELA(3), SMPD1(4), TNFRSF1A(2), TRADD(1) 5491478 31 24 31 15 8 9 1 9 4 0 0.94 1.00 1.00 580 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(4), COPS5(2), CREB1(1), EP300(9), HIF1A(1), JUN(3), NOS3(2), P4HB(4), VHL(1) 4585636 28 24 26 13 10 6 0 9 3 0 0.94 1.00 1.00 581 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(1), B3GNT7(1), B4GALT1(1), B4GALT3(3), B4GALT4(3), CHST1(2), CHST2(4), CHST4(2), CHST6(5), FUT8(2), ST3GAL1(4), ST3GAL4(2) 3335186 30 24 30 11 7 19 2 2 0 0 0.47 1.00 1.00 582 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(3), HLA-DRA(1), HLA-DRB1(2), IFNG(1), IFNGR1(4), IFNGR2(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL18R1(2), IL4(2), IL4R(2) 3388764 29 24 29 10 12 7 0 4 6 0 0.74 1.00 1.00 583 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(3), ARPC1A(4), NCK1(2), NCKAP1(7), NTRK1(4), RAC1(1), WASF1(1), WASF3(1), WASL(2) 4095602 25 23 24 15 6 7 0 6 6 0 0.99 1.00 1.00 584 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(2), DHRSX(4), ESCO1(2), ESCO2(1), MYST3(11), MYST4(4), PNPLA3(1), SH3GLB1(1) 4429174 26 23 26 12 8 6 0 7 5 0 0.93 1.00 1.00 585 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), EPX(4), LPO(2), MPO(4), MTHFR(2), PRDX6(2), TPO(10) 3102896 25 23 25 12 8 9 3 5 0 0 0.86 1.00 1.00 586 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(2), GOSR1(1), SEC22B(4), SNAP23(1), SNAP25(1), STX10(1), STX11(2), STX16(1), STX19(2), STX2(1), STX5(2), STX7(1), TSNARE1(2), USE1(1), VAMP7(3), YKT6(1) 4516750 26 23 26 13 10 5 3 5 3 0 0.94 1.00 1.00 587 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), EPX(4), LPO(2), MPO(4), PRDX1(1), PRDX6(2), TPO(10) 3150600 24 23 24 13 7 8 4 5 0 0 0.94 1.00 1.00 588 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), CREM(2), FOS(2), JUN(3), MAPK3(1), OPRK1(1), POLR2A(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(2) 3426322 22 21 21 10 7 7 0 5 3 0 0.85 1.00 1.00 589 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(1), GPR109B(2), GPR161(2), GPR171(2), GPR18(2), GPR34(1), GPR39(2), GPR45(4), GPR65(3), GPR68(1), GPR75(2), GPR81(1) 2602716 25 21 25 11 8 8 0 8 1 0 0.67 1.00 1.00 590 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(2), POLR1D(1), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLR3A(1), POLR3B(2), POLR3G(1), POLR3H(2) 6288206 23 21 23 13 9 7 1 2 4 0 0.95 1.00 1.00 591 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(2), B3GAT2(2), CHPF(2), CHST11(2), CHST12(1), CHST3(2), CHSY1(2), DSE(4), UST(1), XYLT1(5) 3666978 23 20 23 11 3 8 1 8 3 0 0.87 1.00 1.00 592 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(5), CRY1(2), CRY2(2), CSNK1D(2), NPAS2(1), PER1(5), PER2(2), PER3(2) 4598986 23 20 23 10 7 7 3 5 1 0 0.87 1.00 1.00 593 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(4), CD44(5), CSF1(2), FCGR3A(4), IL1B(1), IL6R(1), SELL(2), TGFB1(1), TGFB2(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(1) 3574774 28 20 28 10 7 10 2 5 4 0 0.70 1.00 1.00 594 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(3), APAF1(4), CASP9(3), DAXX(3), FAS(1), FASLG(1), HSPB2(1), IL1A(1), MAPKAPK2(2), MAPKAPK3(1), TNF(1) 3025288 21 19 20 13 8 5 1 4 3 0 0.99 1.00 1.00 595 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3D(1), CD8A(2), ICAM1(2), ITGAL(1), ITGB2(5), PTPRC(7), THY1(2) 2879684 21 19 21 9 6 6 1 8 0 0 0.84 1.00 1.00 596 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3D(1), CD4(1), ICAM1(2), ITGAL(1), ITGB2(5), PTPRC(7), THY1(2) 3022084 20 19 20 10 6 5 1 7 1 0 0.91 1.00 1.00 597 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(3), ALOX15B(1), DPEP1(3), GGT1(1), LTA4H(2), PLA2G2A(1), PLA2G6(5), PTGES(1), PTGS1(2), TBXAS1(2) 4022444 21 18 21 8 4 13 1 3 0 0 0.57 1.00 1.00 598 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 CCL3(2), FLT3(7), IGF1(3), IL1A(1), IL3(1), IL6(1), TGFB1(1), TGFB2(3) 2184238 19 17 19 11 6 7 1 5 0 0 0.96 1.00 1.00 599 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(4), ATF3(1), HBEGF(1), IFNG(1), IL1A(1), IL1R1(1), JUND(2), MYOG(1), NR4A3(3), WDR1(2) 2930948 17 17 17 10 5 7 1 0 4 0 0.98 1.00 1.00 600 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(2), ACACB(9), FASN(2), MCAT(1), OLAH(2), OXSM(1) 4267550 17 15 17 13 8 5 1 1 2 0 0.98 1.00 1.00 601 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(1), EHHADH(1), HADH(1), HADHA(2), HSD17B4(1), SIRT1(1), SIRT2(2), SIRT7(2), VNN2(5) 3169468 16 15 16 10 2 5 1 4 4 0 0.98 1.00 1.00 602 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT1(1), B4GALT3(3), B4GALT5(2), FUT8(2), ST3GAL1(4), ST3GAL4(2) 2109834 14 14 14 10 4 7 1 2 0 0 0.97 1.00 1.00 603 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT1(3), B3GALT2(3), FUT2(1), FUT3(3), ST3GAL4(2) 1921688 13 13 13 6 5 4 2 2 0 0 0.81 1.00 1.00 604 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), BDH1(4), HMGCL(1), HMGCS1(1), HMGCS2(3), OXCT1(3) 1927206 14 12 14 7 6 5 0 3 0 0 0.91 1.00 1.00 605 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(5), AOC2(2), AOC3(3), CES1(2) 1620868 12 11 12 7 0 4 1 7 0 0 0.93 1.00 1.00 606 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(1), HTR2C(4), PLCB1(8) 1910296 13 11 13 7 4 6 1 2 0 0 0.91 1.00 1.00 607 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPL(3), ALPP(3), ALPPL2(1), FPGS(2), GCH1(1), GGH(2) 1778932 12 10 12 8 5 5 0 2 0 0 0.91 1.00 1.00 608 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(3), LPL(3), NR3C1(1), RXRA(2), TNF(1) 1551626 10 10 10 5 3 5 0 2 0 0 0.82 1.00 1.00 609 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 MDH1(1), ME1(2), PC(2), PDHA1(3), SLC25A11(1) 2462452 9 9 9 10 3 2 0 2 2 0 1.00 1.00 1.00 610 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOA(1), ALDOB(2), TPI1(3) 1041834 7 7 7 4 2 3 0 2 0 0 0.87 1.00 1.00 611 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(3), RAB11A(1), RAB4A(3) 1142226 7 7 7 12 1 5 0 0 1 0 1.00 1.00 1.00 612 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), HMGCL(1), OXCT1(3) 901926 6 6 6 3 0 3 0 3 0 0 0.89 1.00 1.00 613 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(4), SNAP25(1) 869530 5 5 5 3 3 1 0 1 0 0 0.83 1.00 1.00 614 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), NR1I3(1), PTGS1(2) 1417058 4 3 4 4 1 1 0 2 0 0 0.97 1.00 1.00 615 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ7(1), NDUFA13(2) 1072984 3 3 3 4 1 0 0 2 0 0 0.99 1.00 1.00 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 407442 0 0 0 0 0 0 0 0 0 0 1.00 1.00 1.00