E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.028 0.144 -9999.0 0.0 -0.432 12.0 12.0 KLHL20 -0.01 0.112 0.189 1.0 -0.3 12.0 13.0 CYFIP2 0.028 0.048 -9999.0 0.0 -0.509 1.0 1.0 Rac1/GDP 0.003 0.11 0.248 1.0 -0.313 4.0 5.0 ENAH -0.029 0.148 -9999.0 0.0 -0.441 11.0 11.0 AP1M1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.062 -9999.0 0.0 -0.509 2.0 2.0 CTNNB1 0.031 0.019 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.014 0.078 -9999.0 0.0 -0.291 1.0 1.0 ABI1/Sra1/Nap1 -0.033 0.061 -9999.0 0.0 -0.202 12.0 12.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.059 0.082 -9999.0 0.0 -0.289 6.0 6.0 RAPGEF1 -0.018 0.126 -9999.0 0.0 -0.428 7.0 7.0 CTNND1 0.019 0.097 -9999.0 0.0 -0.509 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.154 -9999.0 0.0 -0.427 14.0 14.0 CRK -0.015 0.134 -9999.0 0.0 -0.434 9.0 9.0 E-cadherin/gamma catenin/alpha catenin 0.022 0.126 -9999.0 0.0 -0.333 16.0 16.0 alphaE/beta7 Integrin 0.05 0.016 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.049 -9999.0 0.0 -0.509 1.0 1.0 Rap1/GTP/I-afadin 0.057 0.047 -9999.0 0.0 -0.288 2.0 2.0 DLG1 -0.03 0.148 -9999.0 0.0 -0.417 14.0 14.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.013 0.048 -9999.0 0.0 -0.238 3.0 3.0 MLLT4 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.058 0.047 -9999.0 0.0 -0.288 2.0 2.0 PI3K -0.015 0.063 -9999.0 0.0 -0.312 3.0 3.0 ARF6 0.027 0.063 -9999.0 0.0 -0.509 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.002 0.137 -9999.0 0.0 -0.389 16.0 16.0 TIAM1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.045 0.096 -9999.0 0.0 -0.27 11.0 11.0 AKT1 0.032 0.07 0.162 3.0 -0.221 3.0 6.0 PIK3R1 0.01 0.092 -9999.0 0.0 -0.509 4.0 4.0 CDH1 0.012 0.106 -9999.0 0.0 -0.509 6.0 6.0 RhoA/GDP 0.008 0.107 0.251 1.0 -0.333 2.0 3.0 actin cytoskeleton organization -0.004 0.083 0.148 3.0 -0.218 11.0 14.0 CDC42/GDP 0.006 0.11 0.251 1.0 -0.342 2.0 3.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.016 0.11 -9999.0 0.0 -0.28 20.0 20.0 ITGB7 0.037 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.049 0.102 -9999.0 0.0 -0.287 11.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.069 -9999.0 0.0 -0.269 6.0 6.0 mol:GDP -0.014 0.116 0.249 1.0 -0.34 8.0 9.0 CDC42/GTP/IQGAP1 0.047 0.012 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.005 0.14 -9999.0 0.0 -0.509 11.0 11.0 p120 catenin/RhoA/GDP 0.012 0.118 0.262 1.0 -0.35 2.0 3.0 RAC1/GTP/IQGAP1 0.047 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.046 0.039 -9999.0 0.0 -0.371 1.0 1.0 RHOA 0.032 0.012 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.036 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.035 0.009 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.009 0.077 0.119 1.0 -0.233 12.0 13.0 NME1 0.037 0.004 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.032 0.152 -9999.0 0.0 -0.422 15.0 15.0 regulation of cell-cell adhesion 0.001 0.061 -9999.0 0.0 -0.255 1.0 1.0 WASF2 -0.004 0.047 -9999.0 0.0 -0.137 7.0 7.0 Rap1/GTP 0.014 0.087 -9999.0 0.0 -0.326 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.125 -9999.0 0.0 -0.289 16.0 16.0 CCND1 -0.012 0.095 0.136 1.0 -0.293 12.0 13.0 VAV2 -0.048 0.243 -9999.0 0.0 -0.689 15.0 15.0 RAP1/GDP 0.016 0.101 0.267 1.0 -0.355 1.0 2.0 adherens junction assembly -0.031 0.147 -9999.0 0.0 -0.409 15.0 15.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.047 -9999.0 0.0 -0.509 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.028 0.112 -9999.0 0.0 -0.28 15.0 15.0 E-cadherin/beta catenin -0.0 0.075 -9999.0 0.0 -0.336 7.0 7.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.024 0.141 -9999.0 0.0 -0.428 12.0 12.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.509 2.0 2.0 Rac1/GTP -0.068 0.164 -9999.0 0.0 -0.507 14.0 14.0 E-cadherin/beta catenin/alpha catenin 0.044 0.08 -9999.0 0.0 -0.315 6.0 6.0 ITGAE 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.023 0.157 -9999.0 0.0 -0.436 14.0 14.0