E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.041 0.147 -9999.0 0.0 -0.335 100.0 100.0 KLHL20 -0.016 0.101 0.199 14.0 -0.228 52.0 66.0 CYFIP2 0.038 0.012 -9999.0 0.0 0.0 47.0 47.0 Rac1/GDP -0.012 0.108 0.258 6.0 -0.25 50.0 56.0 ENAH -0.038 0.144 -9999.0 0.0 -0.33 98.0 98.0 AP1M1 0.036 0.014 -9999.0 0.0 0.0 77.0 77.0 RAP1B 0.038 0.013 -9999.0 0.0 0.0 59.0 59.0 RAP1A 0.039 0.01 -9999.0 0.0 0.0 35.0 35.0 CTNNB1 0.04 0.01 -9999.0 0.0 0.0 31.0 31.0 CDC42/GTP 0.003 0.079 0.158 4.0 -0.209 27.0 31.0 ABI1/Sra1/Nap1 -0.033 0.054 -9999.0 0.0 -0.154 66.0 66.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.069 0.068 -9999.0 0.0 -0.112 43.0 43.0 RAPGEF1 -0.035 0.129 0.28 3.0 -0.308 83.0 86.0 CTNND1 0.041 0.007 -9999.0 0.0 0.0 17.0 17.0 regulation of calcium-dependent cell-cell adhesion -0.029 0.154 -9999.0 0.0 -0.335 102.0 102.0 CRK -0.033 0.134 0.251 1.0 -0.325 83.0 84.0 E-cadherin/gamma catenin/alpha catenin 0.05 0.065 -9999.0 0.0 -0.138 42.0 42.0 alphaE/beta7 Integrin 0.05 0.038 -9999.0 0.0 -0.134 17.0 17.0 IQGAP1 0.037 0.014 -9999.0 0.0 0.0 69.0 69.0 NCKAP1 0.04 0.01 -9999.0 0.0 0.0 31.0 31.0 Rap1/GTP/I-afadin 0.043 0.066 -9999.0 0.0 -0.111 68.0 68.0 DLG1 -0.044 0.15 -9999.0 0.0 -0.339 103.0 103.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.033 0.048 -9999.0 0.0 -0.146 55.0 55.0 MLLT4 0.034 0.017 -9999.0 0.0 0.0 107.0 107.0 ARF6/GTP/NME1/Tiam1 0.045 0.062 -9999.0 0.0 -0.108 59.0 59.0 PI3K -0.04 0.062 -9999.0 0.0 -0.203 42.0 42.0 ARF6 0.041 0.008 -9999.0 0.0 0.0 19.0 19.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.038 0.052 -9999.0 0.0 -0.149 30.0 30.0 TIAM1 0.037 0.014 -9999.0 0.0 0.0 72.0 72.0 E-cadherin(dimer)/Ca2+ 0.062 0.072 -9999.0 0.0 -0.127 51.0 51.0 AKT1 -0.008 0.062 0.161 15.0 -0.157 17.0 32.0 PIK3R1 0.034 0.017 -9999.0 0.0 0.0 107.0 107.0 CDH1 0.035 0.016 -9999.0 0.0 0.0 98.0 98.0 RhoA/GDP -0.013 0.108 0.222 5.0 -0.25 52.0 57.0 actin cytoskeleton organization -0.01 0.077 0.163 15.0 -0.167 50.0 65.0 CDC42/GDP -0.012 0.108 0.255 6.0 -0.251 49.0 55.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.002 0.073 -9999.0 0.0 -0.196 55.0 55.0 ITGB7 0.039 0.011 -9999.0 0.0 0.0 40.0 40.0 RAC1 0.04 0.01 -9999.0 0.0 0.0 33.0 33.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.067 0.078 -9999.0 0.0 -0.136 51.0 51.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.046 0.056 -9999.0 0.0 -0.108 48.0 48.0 mol:GDP -0.031 0.113 0.243 7.0 -0.282 52.0 59.0 CDC42/GTP/IQGAP1 0.04 0.046 -9999.0 0.0 -0.114 42.0 42.0 JUP 0.037 0.014 -9999.0 0.0 0.0 67.0 67.0 p120 catenin/RhoA/GDP -0.001 0.116 0.238 4.0 -0.261 48.0 52.0 RAC1/GTP/IQGAP1 0.038 0.046 -9999.0 0.0 -0.113 42.0 42.0 PIP5K1C/AP1M1 0.049 0.026 -9999.0 0.0 -0.136 1.0 1.0 RHOA 0.041 0.007 -9999.0 0.0 0.0 14.0 14.0 CDC42 0.04 0.009 -9999.0 0.0 0.0 24.0 24.0 CTNNA1 0.039 0.011 -9999.0 0.0 0.0 38.0 38.0 positive regulation of S phase of mitotic cell cycle -0.016 0.059 0.122 5.0 -0.122 96.0 101.0 NME1 0.035 0.015 -9999.0 0.0 0.0 91.0 91.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.039 0.147 -9999.0 0.0 -0.345 93.0 93.0 regulation of cell-cell adhesion -0.008 0.064 -9999.0 0.0 -0.153 50.0 50.0 WASF2 -0.007 0.043 0.106 13.0 -0.095 42.0 55.0 Rap1/GTP 0.002 0.087 0.204 9.0 -0.242 24.0 33.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.071 0.083 -9999.0 0.0 -0.121 52.0 52.0 CCND1 -0.02 0.071 0.14 5.0 -0.149 96.0 101.0 VAV2 -0.051 0.215 -9999.0 0.0 -0.614 50.0 50.0 RAP1/GDP 0.0 0.098 0.226 10.0 -0.252 31.0 41.0 adherens junction assembly -0.038 0.143 -9999.0 0.0 -0.335 93.0 93.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.04 0.009 -9999.0 0.0 0.0 26.0 26.0 PIP5K1C 0.038 0.012 -9999.0 0.0 0.0 54.0 54.0 regulation of heterotypic cell-cell adhesion 0.045 0.076 0.219 5.0 -0.126 60.0 65.0 E-cadherin/beta catenin 0.007 0.042 0.146 1.0 -0.228 14.0 15.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.037 0.141 -9999.0 0.0 -0.331 94.0 94.0 PIK3CA 0.03 0.019 -9999.0 0.0 0.0 155.0 155.0 Rac1/GTP -0.056 0.132 -9999.0 0.0 -0.354 64.0 64.0 E-cadherin/beta catenin/alpha catenin 0.052 0.065 -9999.0 0.0 -0.13 48.0 48.0 ITGAE 0.039 0.01 -9999.0 0.0 0.0 36.0 36.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.03 0.157 -9999.0 0.0 -0.342 102.0 102.0