Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.049 0.045 0.149 18.0 -9999.0 0.0 18.0 KIRREL 0.041 0.017 0.084 2.0 -0.037 2.0 4.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.049 0.045 -9999.0 0.0 -0.149 18.0 18.0 PLCG1 0.038 0.012 -9999.0 0.0 0.0 50.0 50.0 ARRB2 0.039 0.011 -9999.0 0.0 0.0 43.0 43.0 WASL 0.04 0.008 -9999.0 0.0 0.0 23.0 23.0 Nephrin/NEPH1/podocin/CD2AP 0.073 0.071 0.212 1.0 -0.117 41.0 42.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.031 0.057 -9999.0 0.0 -0.143 31.0 31.0 FYN 0.003 0.065 0.172 58.0 -0.181 3.0 61.0 mol:Ca2+ 0.075 0.064 0.204 1.0 -0.128 25.0 26.0 mol:DAG 0.077 0.065 0.208 1.0 -0.129 25.0 26.0 NPHS2 0.043 0.02 -9999.0 0.0 -0.043 19.0 19.0 mol:IP3 0.077 0.065 0.208 1.0 -0.129 25.0 26.0 regulation of endocytosis 0.054 0.058 -9999.0 0.0 -0.12 20.0 20.0 Nephrin/NEPH1/podocin/Cholesterol 0.064 0.049 0.174 2.0 -0.11 18.0 20.0 establishment of cell polarity 0.049 0.045 -9999.0 0.0 -0.149 18.0 18.0 Nephrin/NEPH1/podocin/NCK1-2 0.086 0.078 -9999.0 0.0 -0.111 38.0 38.0 Nephrin/NEPH1/beta Arrestin2 0.056 0.06 -9999.0 0.0 -0.121 20.0 20.0 NPHS1 0.04 0.022 0.084 5.0 -0.044 17.0 22.0 Nephrin/NEPH1/podocin 0.055 0.056 0.218 1.0 -0.124 19.0 20.0 TJP1 0.037 0.013 -9999.0 0.0 0.0 64.0 64.0 NCK1 0.036 0.015 -9999.0 0.0 0.0 79.0 79.0 NCK2 0.042 0.004 -9999.0 0.0 0.0 6.0 6.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.079 0.066 0.212 1.0 -0.129 25.0 26.0 CD2AP 0.037 0.014 -9999.0 0.0 0.0 67.0 67.0 Nephrin/NEPH1/podocin/GRB2 0.085 0.059 0.212 1.0 -0.119 19.0 20.0 GRB2 0.041 0.007 -9999.0 0.0 0.0 16.0 16.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.005 0.071 0.176 65.0 -0.123 3.0 68.0 cytoskeleton organization 0.013 0.054 0.25 4.0 -0.157 15.0 19.0 Nephrin/NEPH1 0.042 0.034 -9999.0 0.0 -0.096 18.0 18.0 Nephrin/NEPH1/ZO-1 0.055 0.062 -9999.0 0.0 -0.131 37.0 37.0