Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.065 0.175 -9999.0 0.0 -0.392 123.0 123.0 IHH 0.022 0.067 -9999.0 0.0 -0.099 128.0 128.0 SHH Np/Cholesterol/GAS1 0.027 0.027 -9999.0 0.0 -0.105 15.0 15.0 LRPAP1 0.036 0.014 -9999.0 0.0 0.0 77.0 77.0 dorsoventral neural tube patterning -0.027 0.027 0.105 15.0 -9999.0 0.0 15.0 SMO/beta Arrestin2 0.018 0.118 0.245 1.0 -0.201 106.0 107.0 SMO -0.002 0.108 -9999.0 0.0 -0.205 110.0 110.0 AKT1 -0.013 0.132 -9999.0 0.0 -0.398 35.0 35.0 ARRB2 0.039 0.011 -9999.0 0.0 0.0 43.0 43.0 BOC 0.036 0.015 -9999.0 0.0 0.0 85.0 85.0 ADRBK1 0.041 0.005 -9999.0 0.0 0.0 7.0 7.0 heart looping -0.001 0.108 0.192 3.0 -0.203 110.0 113.0 STIL 0.0 0.096 0.205 29.0 -0.172 103.0 132.0 DHH N/PTCH2 0.058 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.003 0.108 -9999.0 0.0 -0.19 127.0 127.0 PIK3CA 0.03 0.019 -9999.0 0.0 0.0 155.0 155.0 DHH 0.041 0.006 -9999.0 0.0 0.0 13.0 13.0 PTHLH -0.032 0.172 -9999.0 0.0 -0.377 106.0 106.0 determination of left/right symmetry -0.001 0.108 0.192 3.0 -0.203 110.0 113.0 PIK3R1 0.034 0.017 -9999.0 0.0 0.0 107.0 107.0 skeletal system development -0.032 0.171 -9999.0 0.0 -0.375 106.0 106.0 IHH N/Hhip 0.035 0.055 -9999.0 0.0 -0.06 120.0 120.0 DHH N/Hhip 0.055 0.022 -9999.0 0.0 -0.136 1.0 1.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.001 0.108 0.192 3.0 -0.203 110.0 113.0 pancreas development 0.038 0.012 -9999.0 0.0 0.0 55.0 55.0 HHAT 0.04 0.008 -9999.0 0.0 0.0 23.0 23.0 PI3K 0.024 0.061 -9999.0 0.0 -0.151 47.0 47.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.037 0.014 -9999.0 0.0 0.0 68.0 68.0 somite specification -0.001 0.108 0.192 3.0 -0.203 110.0 113.0 SHH Np/Cholesterol/PTCH1 -0.006 0.085 -9999.0 0.0 -0.171 108.0 108.0 SHH Np/Cholesterol/PTCH2 0.032 0.017 -9999.0 0.0 -0.105 3.0 3.0 SHH Np/Cholesterol/Megalin 0.021 0.027 -9999.0 0.0 -0.104 14.0 14.0 SHH -0.018 0.007 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.036 0.096 -9999.0 0.0 -0.21 128.0 128.0 SMO/Vitamin D3 -0.006 0.1 0.195 19.0 -0.198 106.0 125.0 SHH Np/Cholesterol/Hhip 0.03 0.019 -9999.0 0.0 -0.105 4.0 4.0 LRP2 0.03 0.019 -9999.0 0.0 0.0 162.0 162.0 receptor-mediated endocytosis 0.002 0.101 0.189 21.0 -0.183 103.0 124.0 SHH Np/Cholesterol/BOC 0.025 0.029 -9999.0 0.0 -0.11 17.0 17.0 SHH Np/Cholesterol/CDO 0.023 0.035 -9999.0 0.0 -0.105 31.0 31.0 mesenchymal cell differentiation -0.03 0.019 0.104 4.0 -9999.0 0.0 4.0 mol:Vitamin D3 -0.012 0.089 0.204 26.0 -0.172 107.0 133.0 IHH N/PTCH2 0.039 0.054 -9999.0 0.0 -0.059 119.0 119.0 CDON 0.035 0.016 -9999.0 0.0 0.0 93.0 93.0 IHH N/PTCH1 -0.02 0.107 -9999.0 0.0 -0.212 128.0 128.0 Megalin/LRPAP1 0.029 0.053 -9999.0 0.0 -0.139 37.0 37.0 PTCH2 0.04 0.009 -9999.0 0.0 0.0 27.0 27.0 SHH Np/Cholesterol 0.034 0.047 0.196 42.0 -0.098 3.0 45.0 PTCH1 -0.036 0.096 -9999.0 0.0 -0.211 128.0 128.0 HHIP 0.038 0.012 -9999.0 0.0 0.0 55.0 55.0