Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.003 0.07 -9999.0 0.0 -0.191 53.0 53.0 epithelial cell differentiation 0.056 0.068 -9999.0 0.0 -0.126 51.0 51.0 CYFIP2 0.038 0.012 -9999.0 0.0 0.0 47.0 47.0 ENAH -0.033 0.071 0.221 12.0 -0.219 4.0 16.0 EGFR 0.037 0.014 -9999.0 0.0 0.0 72.0 72.0 EPHA2 0.039 0.01 -9999.0 0.0 0.0 35.0 35.0 MYO6 -0.03 0.048 0.182 7.0 -0.211 17.0 24.0 CTNNB1 0.04 0.01 -9999.0 0.0 0.0 31.0 31.0 ABI1/Sra1/Nap1 0.061 0.058 -9999.0 0.0 -0.125 41.0 41.0 AQP5 -0.076 0.14 0.178 4.0 -0.368 98.0 102.0 CTNND1 0.041 0.007 -9999.0 0.0 0.0 17.0 17.0 mol:PI-4-5-P2 -0.03 0.043 0.18 6.0 -0.198 12.0 18.0 regulation of calcium-dependent cell-cell adhesion -0.028 0.043 0.181 6.0 -0.198 12.0 18.0 EGF 0.038 0.012 -9999.0 0.0 0.0 52.0 52.0 NCKAP1 0.04 0.01 -9999.0 0.0 0.0 31.0 31.0 AQP3 -0.024 0.058 0.178 4.0 -0.293 15.0 19.0 cortical microtubule organization 0.056 0.068 -9999.0 0.0 -0.126 51.0 51.0 GO:0000145 -0.03 0.039 0.16 6.0 -0.189 12.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.062 0.072 -9999.0 0.0 -0.127 51.0 51.0 MLLT4 0.034 0.017 -9999.0 0.0 0.0 107.0 107.0 ARF6/GDP -0.05 0.046 -9999.0 0.0 -0.191 24.0 24.0 ARF6 0.041 0.008 -9999.0 0.0 0.0 19.0 19.0 Ephrin A1/EPHA2/NCK1/GIT1 0.061 0.077 -9999.0 0.0 -0.121 62.0 62.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.017 0.048 0.198 4.0 -0.21 15.0 19.0 PVRL2 0.039 0.011 -9999.0 0.0 0.0 44.0 44.0 ZYX -0.028 0.039 0.184 5.0 -0.204 8.0 13.0 ARF6/GTP 0.066 0.083 -9999.0 0.0 -0.121 64.0 64.0 CDH1 0.035 0.016 -9999.0 0.0 0.0 98.0 98.0 EGFR/EGFR/EGF/EGF 0.037 0.075 -9999.0 0.0 -0.129 66.0 66.0 RhoA/GDP 0.056 0.072 -9999.0 0.0 -0.125 53.0 53.0 actin cytoskeleton organization -0.032 0.048 0.16 6.0 -0.233 16.0 22.0 IGF-1R heterotetramer 0.033 0.017 -9999.0 0.0 0.0 118.0 118.0 GIT1 0.04 0.009 -9999.0 0.0 0.0 27.0 27.0 IGF1R 0.033 0.017 -9999.0 0.0 0.0 118.0 118.0 IGF1 0.036 0.015 -9999.0 0.0 0.0 84.0 84.0 DIAPH1 -0.002 0.222 -9999.0 0.0 -0.576 60.0 60.0 Wnt receptor signaling pathway -0.056 0.068 0.126 51.0 -9999.0 0.0 51.0 RHOA 0.041 0.007 -9999.0 0.0 0.0 14.0 14.0 RhoA/GTP -0.049 0.045 -9999.0 0.0 -0.186 23.0 23.0 CTNNA1 0.039 0.011 -9999.0 0.0 0.0 38.0 38.0 VCL -0.033 0.049 0.162 6.0 -0.238 16.0 22.0 EFNA1 0.034 0.017 -9999.0 0.0 0.0 107.0 107.0 LPP -0.029 0.044 0.168 6.0 -0.2 14.0 20.0 Ephrin A1/EPHA2 0.032 0.076 -9999.0 0.0 -0.126 74.0 74.0 SEC6/SEC8 -0.045 0.043 -9999.0 0.0 -0.137 68.0 68.0 MGAT3 -0.029 0.044 0.183 6.0 -0.201 12.0 18.0 HGF/MET 0.016 0.086 -9999.0 0.0 -0.128 113.0 113.0 HGF 0.04 0.009 -9999.0 0.0 0.0 29.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.003 0.07 -9999.0 0.0 -0.192 53.0 53.0 actin cable formation 0.002 0.096 0.262 24.0 -0.253 14.0 38.0 KIAA1543 -0.033 0.043 0.166 6.0 -0.201 13.0 19.0 KIFC3 -0.032 0.041 0.18 5.0 -0.201 12.0 17.0 NCK1 0.036 0.015 -9999.0 0.0 0.0 79.0 79.0 EXOC3 0.041 0.005 -9999.0 0.0 0.0 8.0 8.0 ACTN1 -0.031 0.049 0.182 7.0 -0.217 16.0 23.0 NCK1/GIT1 0.044 0.047 -9999.0 0.0 -0.135 30.0 30.0 mol:GDP 0.056 0.068 -9999.0 0.0 -0.126 51.0 51.0 EXOC4 0.038 0.012 -9999.0 0.0 0.0 49.0 49.0 STX4 -0.029 0.034 0.036 8.0 -0.122 49.0 57.0 PIP5K1C -0.031 0.043 0.181 6.0 -0.201 12.0 18.0 LIMA1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.04 0.009 -9999.0 0.0 0.0 26.0 26.0 ROCK1 -0.026 0.084 0.242 15.0 -0.23 4.0 19.0 adherens junction assembly -0.051 0.128 -9999.0 0.0 -0.386 46.0 46.0 IGF-1R heterotetramer/IGF1 0.023 0.083 -9999.0 0.0 -0.128 93.0 93.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.051 -9999.0 0.0 -0.139 33.0 33.0 MET 0.027 0.02 -9999.0 0.0 0.0 198.0 198.0 PLEKHA7 -0.031 0.045 0.182 7.0 -0.202 14.0 21.0 mol:GTP 0.058 0.075 -9999.0 0.0 -0.121 62.0 62.0 establishment of epithelial cell apical/basal polarity -0.038 0.056 0.136 25.0 -0.202 16.0 41.0 cortical actin cytoskeleton stabilization 0.003 0.07 -9999.0 0.0 -0.191 53.0 53.0 regulation of cell-cell adhesion -0.032 0.048 0.16 6.0 -0.233 16.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.003 0.07 -9999.0 0.0 -0.192 53.0 53.0