E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.037 0.173 -9999.0 0.0 -0.452 74.0 74.0 KLHL20 -0.015 0.1 -9999.0 0.0 -0.259 23.0 23.0 CYFIP2 -0.042 0.163 -9999.0 0.0 -0.464 65.0 65.0 Rac1/GDP 0.006 0.113 -9999.0 0.0 -0.302 20.0 20.0 ENAH -0.036 0.175 -9999.0 0.0 -0.448 76.0 76.0 AP1M1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 RAP1B 0.012 0.044 -9999.0 0.0 -0.324 8.0 8.0 RAP1A 0.011 0.062 -9999.0 0.0 -0.521 7.0 7.0 CTNNB1 0.001 0.09 -9999.0 0.0 -0.452 19.0 19.0 CDC42/GTP -0.033 0.07 -9999.0 0.0 -0.299 10.0 10.0 ABI1/Sra1/Nap1 -0.042 0.054 -9999.0 0.0 -0.171 37.0 37.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.006 0.115 -9999.0 0.0 -0.275 79.0 79.0 RAPGEF1 -0.015 0.151 -9999.0 0.0 -0.377 74.0 74.0 CTNND1 0.016 0.029 -9999.0 0.0 -0.346 3.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.039 0.174 -9999.0 0.0 -0.461 74.0 74.0 CRK -0.025 0.162 -9999.0 0.0 -0.412 75.0 75.0 E-cadherin/gamma catenin/alpha catenin -0.011 0.115 -9999.0 0.0 -0.309 65.0 65.0 alphaE/beta7 Integrin 0.023 0.038 -9999.0 0.0 -0.369 5.0 5.0 IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.015 0.031 -9999.0 0.0 -0.324 4.0 4.0 Rap1/GTP/I-afadin 0.014 0.074 -9999.0 0.0 -0.281 29.0 29.0 DLG1 -0.031 0.169 -9999.0 0.0 -0.442 74.0 74.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.055 -9999.0 0.0 -0.216 15.0 15.0 MLLT4 -0.006 0.106 -9999.0 0.0 -0.46 26.0 26.0 ARF6/GTP/NME1/Tiam1 0.023 0.053 -9999.0 0.0 -0.304 10.0 10.0 PI3K -0.036 0.07 -9999.0 0.0 -0.281 15.0 15.0 ARF6 0.016 0.033 -9999.0 0.0 -0.521 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.027 0.133 -9999.0 0.0 -0.374 64.0 64.0 TIAM1 0.006 0.073 -9999.0 0.0 -0.44 13.0 13.0 E-cadherin(dimer)/Ca2+ -0.005 0.106 -9999.0 0.0 -0.259 76.0 76.0 AKT1 -0.022 0.043 -9999.0 0.0 -0.174 14.0 14.0 PIK3R1 -0.009 0.109 -9999.0 0.0 -0.422 32.0 32.0 CDH1 -0.049 0.173 -9999.0 0.0 -0.48 71.0 71.0 RhoA/GDP 0.002 0.121 -9999.0 0.0 -0.314 29.0 29.0 actin cytoskeleton organization -0.009 0.075 -9999.0 0.0 -0.186 23.0 23.0 CDC42/GDP 0.007 0.113 -9999.0 0.0 -0.288 24.0 24.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.008 0.09 -9999.0 0.0 -0.24 66.0 66.0 ITGB7 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.005 0.114 -9999.0 0.0 -0.275 76.0 76.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.014 0.105 -9999.0 0.0 -0.266 75.0 75.0 mol:GDP -0.004 0.127 -9999.0 0.0 -0.298 75.0 75.0 CDC42/GTP/IQGAP1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.011 0.056 -9999.0 0.0 -0.422 8.0 8.0 p120 catenin/RhoA/GDP 0.002 0.122 -9999.0 0.0 -0.327 25.0 25.0 RAC1/GTP/IQGAP1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.023 0.035 -9999.0 0.0 -0.369 4.0 4.0 RHOA 0.005 0.08 -9999.0 0.0 -0.521 12.0 12.0 CDC42 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.017 0.023 -9999.0 0.0 -0.521 1.0 1.0 positive regulation of S phase of mitotic cell cycle -0.028 0.095 -9999.0 0.0 -0.204 98.0 98.0 NME1 0.012 0.039 -9999.0 0.0 -0.258 11.0 11.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.033 0.172 -9999.0 0.0 -0.443 75.0 75.0 regulation of cell-cell adhesion -0.029 0.062 -9999.0 0.0 -0.261 10.0 10.0 WASF2 -0.021 0.031 -9999.0 0.0 -0.195 1.0 1.0 Rap1/GTP -0.038 0.08 -9999.0 0.0 -0.345 10.0 10.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.009 0.104 -9999.0 0.0 -0.249 70.0 70.0 CCND1 -0.036 0.116 -9999.0 0.0 -0.256 97.0 97.0 VAV2 -0.023 0.159 -9999.0 0.0 -0.404 74.0 74.0 RAP1/GDP 0.004 0.106 -9999.0 0.0 -0.357 9.0 9.0 adherens junction assembly -0.032 0.167 -9999.0 0.0 -0.429 75.0 75.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.016 0.021 -9999.0 0.0 -0.258 3.0 3.0 PIP5K1C 0.014 0.042 -9999.0 0.0 -0.455 4.0 4.0 regulation of heterotypic cell-cell adhesion 0.006 0.108 -9999.0 0.0 -0.238 72.0 72.0 E-cadherin/beta catenin -0.045 0.113 -9999.0 0.0 -0.343 64.0 64.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.033 0.17 -9999.0 0.0 -0.44 75.0 75.0 PIK3CA 0.016 0.029 -9999.0 0.0 -0.346 3.0 3.0 Rac1/GTP -0.079 0.123 -9999.0 0.0 -0.411 29.0 29.0 E-cadherin/beta catenin/alpha catenin -0.017 0.122 -9999.0 0.0 -0.312 75.0 75.0 ITGAE 0.013 0.052 -9999.0 0.0 -0.521 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.04 0.178 -9999.0 0.0 -0.471 74.0 74.0