Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.099 0.254 -9999.0 0.0 -0.62 80.0 80.0 IHH -0.013 0.093 -9999.0 0.0 -0.483 14.0 14.0 SHH Np/Cholesterol/GAS1 -0.057 0.141 -9999.0 0.0 -0.29 133.0 133.0 LRPAP1 0.016 0.026 -9999.0 0.0 -0.39 2.0 2.0 dorsoventral neural tube patterning 0.056 0.14 0.288 133.0 -9999.0 0.0 133.0 SMO/beta Arrestin2 -0.053 0.169 -9999.0 0.0 -0.467 47.0 47.0 SMO -0.064 0.177 -9999.0 0.0 -0.497 47.0 47.0 AKT1 -0.027 0.134 -9999.0 0.0 -0.515 21.0 21.0 ARRB2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.018 0.12 -9999.0 0.0 -0.379 48.0 48.0 ADRBK1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.063 0.175 -9999.0 0.0 -0.49 47.0 47.0 STIL -0.052 0.148 -9999.0 0.0 -0.374 51.0 51.0 DHH N/PTCH2 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.027 0.126 -9999.0 0.0 -0.369 23.0 23.0 PIK3CA 0.016 0.029 -9999.0 0.0 -0.346 3.0 3.0 DHH 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.119 0.308 -9999.0 0.0 -0.832 64.0 64.0 determination of left/right symmetry -0.063 0.175 -9999.0 0.0 -0.49 47.0 47.0 PIK3R1 -0.009 0.109 -9999.0 0.0 -0.422 32.0 32.0 skeletal system development -0.117 0.304 -9999.0 0.0 -0.821 64.0 64.0 IHH N/Hhip 0.004 0.069 -9999.0 0.0 -0.323 17.0 17.0 DHH N/Hhip 0.021 0.037 -9999.0 0.0 -0.369 3.0 3.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.063 0.175 -9999.0 0.0 -0.49 47.0 47.0 pancreas development 0.01 0.052 -9999.0 0.0 -0.329 11.0 11.0 HHAT -0.045 0.172 -9999.0 0.0 -0.509 63.0 63.0 PI3K 0.006 0.082 -9999.0 0.0 -0.369 21.0 21.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.072 0.194 -9999.0 0.0 -0.467 98.0 98.0 somite specification -0.063 0.175 -9999.0 0.0 -0.49 47.0 47.0 SHH Np/Cholesterol/PTCH1 -0.048 0.143 -9999.0 0.0 -0.37 43.0 43.0 SHH Np/Cholesterol/PTCH2 -0.007 0.098 -9999.0 0.0 -0.275 61.0 61.0 SHH Np/Cholesterol/Megalin -0.102 0.182 -9999.0 0.0 -0.333 181.0 181.0 SHH -0.021 0.126 -9999.0 0.0 -0.369 61.0 61.0 catabolic process -0.042 0.141 -9999.0 0.0 -0.359 46.0 46.0 SMO/Vitamin D3 -0.06 0.165 -9999.0 0.0 -0.414 55.0 55.0 SHH Np/Cholesterol/Hhip -0.01 0.101 -9999.0 0.0 -0.277 64.0 64.0 LRP2 -0.156 0.245 -9999.0 0.0 -0.484 183.0 183.0 receptor-mediated endocytosis -0.119 0.197 -9999.0 0.0 -0.487 75.0 75.0 SHH Np/Cholesterol/BOC -0.026 0.115 -9999.0 0.0 -0.283 83.0 83.0 SHH Np/Cholesterol/CDO -0.019 0.112 -9999.0 0.0 -0.287 74.0 74.0 mesenchymal cell differentiation 0.011 0.1 0.276 64.0 -9999.0 0.0 64.0 mol:Vitamin D3 -0.046 0.145 -9999.0 0.0 -0.37 43.0 43.0 IHH N/PTCH2 0.01 0.055 -9999.0 0.0 -0.322 11.0 11.0 CDON -0.004 0.099 -9999.0 0.0 -0.414 27.0 27.0 IHH N/PTCH1 -0.04 0.144 -9999.0 0.0 -0.361 46.0 46.0 Megalin/LRPAP1 -0.101 0.181 -9999.0 0.0 -0.371 158.0 158.0 PTCH2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.017 0.097 -9999.0 0.0 -0.284 61.0 61.0 PTCH1 -0.042 0.142 -9999.0 0.0 -0.36 46.0 46.0 HHIP 0.01 0.052 -9999.0 0.0 -0.33 11.0 11.0