E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.069 0.164 -9999.0 0.0 -0.338 126.0 126.0 KLHL20 -0.025 0.09 0.247 1.0 -0.238 22.0 23.0 CYFIP2 -0.006 0.128 -9999.0 0.0 -0.421 44.0 44.0 Rac1/GDP -0.033 0.119 0.265 5.0 -0.265 60.0 65.0 ENAH -0.064 0.161 -9999.0 0.0 -0.354 102.0 102.0 AP1M1 0.034 0.021 -9999.0 0.0 -0.421 1.0 1.0 RAP1B 0.032 0.03 -9999.0 0.0 -0.421 2.0 2.0 RAP1A 0.03 0.05 -9999.0 0.0 -0.421 6.0 6.0 CTNNB1 0.024 0.067 -9999.0 0.0 -0.421 11.0 11.0 CDC42/GTP -0.012 0.083 -9999.0 0.0 -0.246 8.0 8.0 ABI1/Sra1/Nap1 -0.046 0.054 -9999.0 0.0 -0.158 41.0 41.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.03 0.104 -9999.0 0.0 -0.234 58.0 58.0 RAPGEF1 -0.07 0.154 0.236 3.0 -0.367 77.0 80.0 CTNND1 0.033 0.022 -9999.0 0.0 -0.421 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.073 0.182 -9999.0 0.0 -0.351 143.0 143.0 CRK -0.067 0.162 -9999.0 0.0 -0.385 82.0 82.0 E-cadherin/gamma catenin/alpha catenin 0.019 0.098 -9999.0 0.0 -0.261 48.0 48.0 alphaE/beta7 Integrin 0.044 0.038 -9999.0 0.0 -0.301 5.0 5.0 IQGAP1 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.034 0.021 -9999.0 0.0 -0.421 1.0 1.0 Rap1/GTP/I-afadin 0.047 0.063 -9999.0 0.0 -0.23 21.0 21.0 DLG1 -0.081 0.176 -9999.0 0.0 -0.346 144.0 144.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.03 0.056 -9999.0 0.0 -0.174 19.0 19.0 MLLT4 0.02 0.075 -9999.0 0.0 -0.421 14.0 14.0 ARF6/GTP/NME1/Tiam1 0.056 0.045 -9999.0 0.0 -0.235 9.0 9.0 PI3K -0.035 0.074 -9999.0 0.0 -0.223 19.0 19.0 ARF6 0.033 0.029 -9999.0 0.0 -0.421 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.004 0.104 -9999.0 0.0 -0.306 48.0 48.0 TIAM1 0.028 0.057 -9999.0 0.0 -0.421 8.0 8.0 E-cadherin(dimer)/Ca2+ 0.03 0.096 -9999.0 0.0 -0.219 56.0 56.0 AKT1 -0.024 0.053 0.176 4.0 -0.168 6.0 10.0 PIK3R1 0.018 0.082 -9999.0 0.0 -0.421 17.0 17.0 CDH1 -0.012 0.129 -9999.0 0.0 -0.421 45.0 45.0 RhoA/GDP -0.033 0.122 0.264 5.0 -0.271 62.0 67.0 actin cytoskeleton organization -0.017 0.068 0.173 2.0 -0.175 21.0 23.0 CDC42/GDP -0.031 0.118 0.264 5.0 -0.263 62.0 67.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.01 0.077 -9999.0 0.0 -0.217 55.0 55.0 ITGB7 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.033 0.103 -9999.0 0.0 -0.234 56.0 56.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.018 0.087 -9999.0 0.0 -0.216 55.0 55.0 mol:GDP -0.052 0.124 0.264 5.0 -0.298 65.0 70.0 CDC42/GTP/IQGAP1 0.045 0.013 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.028 0.042 -9999.0 0.0 -0.421 4.0 4.0 p120 catenin/RhoA/GDP -0.029 0.129 0.275 4.0 -0.28 60.0 64.0 RAC1/GTP/IQGAP1 0.045 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.048 0.033 -9999.0 0.0 -0.301 4.0 4.0 RHOA 0.026 0.061 -9999.0 0.0 -0.421 9.0 9.0 CDC42 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.03 0.077 0.141 2.0 -0.184 82.0 84.0 NME1 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.078 0.174 -9999.0 0.0 -0.349 136.0 136.0 regulation of cell-cell adhesion -0.018 0.069 -9999.0 0.0 -0.201 13.0 13.0 WASF2 -0.016 0.041 0.109 3.0 -0.107 15.0 18.0 Rap1/GTP -0.014 0.093 0.246 2.0 -0.252 13.0 15.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.037 0.103 -9999.0 0.0 -0.228 52.0 52.0 CCND1 -0.038 0.095 0.161 2.0 -0.228 82.0 84.0 VAV2 -0.066 0.187 -9999.0 0.0 -0.499 26.0 26.0 RAP1/GDP -0.018 0.103 0.267 2.0 -0.27 13.0 15.0 adherens junction assembly -0.077 0.17 -9999.0 0.0 -0.339 137.0 137.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.032 0.036 -9999.0 0.0 -0.421 3.0 3.0 regulation of heterotypic cell-cell adhesion 0.028 0.105 -9999.0 0.0 -0.22 61.0 61.0 E-cadherin/beta catenin -0.024 0.102 -9999.0 0.0 -0.287 63.0 63.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.079 0.174 -9999.0 0.0 -0.361 122.0 122.0 PIK3CA 0.033 0.022 -9999.0 0.0 -0.421 1.0 1.0 Rac1/GTP -0.076 0.13 -9999.0 0.0 -0.374 34.0 34.0 E-cadherin/beta catenin/alpha catenin 0.02 0.102 -9999.0 0.0 -0.255 55.0 55.0 ITGAE 0.028 0.046 -9999.0 0.0 -0.421 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.074 0.186 -9999.0 0.0 -0.359 143.0 143.0