Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.038 0.192 -9999.0 0.0 -0.588 51.0 51.0 IHH 0.017 0.087 -9999.0 0.0 -0.271 26.0 26.0 SHH Np/Cholesterol/GAS1 -0.026 0.105 -9999.0 0.0 -0.236 98.0 98.0 LRPAP1 0.034 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.026 0.104 0.234 98.0 -9999.0 0.0 98.0 SMO/beta Arrestin2 -0.019 0.166 -9999.0 0.0 -0.347 85.0 85.0 SMO -0.035 0.159 -9999.0 0.0 -0.357 86.0 86.0 AKT1 -0.013 0.155 -9999.0 0.0 -0.539 29.0 29.0 ARRB2 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.015 0.089 -9999.0 0.0 -0.421 20.0 20.0 ADRBK1 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.034 0.157 -9999.0 0.0 -0.353 86.0 86.0 STIL -0.004 0.133 0.195 70.0 -0.251 63.0 133.0 DHH N/PTCH2 0.051 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.0 0.116 -9999.0 0.0 -0.288 67.0 67.0 PIK3CA 0.033 0.022 -9999.0 0.0 -0.421 1.0 1.0 DHH 0.035 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.062 0.247 -9999.0 0.0 -0.731 54.0 54.0 determination of left/right symmetry -0.034 0.157 -9999.0 0.0 -0.353 86.0 86.0 PIK3R1 0.018 0.082 -9999.0 0.0 -0.421 17.0 17.0 skeletal system development -0.061 0.245 -9999.0 0.0 -0.723 54.0 54.0 IHH N/Hhip 0.034 0.064 -9999.0 0.0 -0.287 12.0 12.0 DHH N/Hhip 0.049 0.029 -9999.0 0.0 -0.301 3.0 3.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.034 0.157 -9999.0 0.0 -0.353 86.0 86.0 pancreas development 0.032 0.036 -9999.0 0.0 -0.421 3.0 3.0 HHAT -0.016 0.133 -9999.0 0.0 -0.421 49.0 49.0 PI3K 0.035 0.067 -9999.0 0.0 -0.301 18.0 18.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.03 0.158 -9999.0 0.0 -0.421 71.0 71.0 somite specification -0.034 0.157 -9999.0 0.0 -0.353 86.0 86.0 SHH Np/Cholesterol/PTCH1 -0.029 0.106 -9999.0 0.0 -0.234 99.0 99.0 SHH Np/Cholesterol/PTCH2 0.003 0.073 -9999.0 0.0 -0.231 43.0 43.0 SHH Np/Cholesterol/Megalin -0.055 0.138 -9999.0 0.0 -0.273 133.0 133.0 SHH -0.016 0.089 -9999.0 0.0 -0.301 45.0 45.0 catabolic process -0.023 0.12 -9999.0 0.0 -0.32 68.0 68.0 SMO/Vitamin D3 -0.016 0.15 0.2 36.0 -0.33 60.0 96.0 SHH Np/Cholesterol/Hhip 0.002 0.074 -9999.0 0.0 -0.231 44.0 44.0 LRP2 -0.097 0.206 -9999.0 0.0 -0.421 145.0 145.0 receptor-mediated endocytosis -0.069 0.173 -9999.0 0.0 -0.359 95.0 95.0 SHH Np/Cholesterol/BOC -0.007 0.084 -9999.0 0.0 -0.23 61.0 61.0 SHH Np/Cholesterol/CDO -0.007 0.082 -9999.0 0.0 -0.236 55.0 55.0 mesenchymal cell differentiation -0.002 0.073 0.23 44.0 -9999.0 0.0 44.0 mol:Vitamin D3 -0.005 0.131 0.201 62.0 -0.234 99.0 161.0 IHH N/PTCH2 0.037 0.059 -9999.0 0.0 -0.272 10.0 10.0 CDON 0.02 0.067 -9999.0 0.0 -0.421 11.0 11.0 IHH N/PTCH1 -0.004 0.128 -9999.0 0.0 -0.322 68.0 68.0 Megalin/LRPAP1 -0.051 0.159 -9999.0 0.0 -0.3 145.0 145.0 PTCH2 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.006 0.07 -9999.0 0.0 -0.228 45.0 45.0 PTCH1 -0.023 0.12 -9999.0 0.0 -0.321 68.0 68.0 HHIP 0.032 0.036 -9999.0 0.0 -0.421 3.0 3.0