Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.019 0.211 -9999.0 0.0 -0.886 5.0 5.0 IHH 0.001 0.131 -9999.0 0.0 -0.606 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.153 0.206 -9999.0 0.0 -0.422 40.0 40.0 LRPAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.152 0.204 0.419 40.0 -9999.0 0.0 40.0 SMO/beta Arrestin2 -0.009 0.193 -9999.0 0.0 -0.732 6.0 6.0 SMO -0.019 0.204 -9999.0 0.0 -0.713 8.0 8.0 AKT1 0.011 0.147 -9999.0 0.0 -1.041 2.0 2.0 ARRB2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.006 0.11 -9999.0 0.0 -0.511 7.0 7.0 ADRBK1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.018 0.2 -9999.0 0.0 -0.695 8.0 8.0 STIL -0.007 0.193 -9999.0 0.0 -0.61 9.0 9.0 DHH N/PTCH2 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.024 0.161 -9999.0 0.0 -0.735 5.0 5.0 PIK3CA 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.011 0.252 -9999.0 0.0 -0.964 8.0 8.0 determination of left/right symmetry -0.018 0.2 -9999.0 0.0 -0.695 8.0 8.0 PIK3R1 0.005 0.09 -9999.0 0.0 -0.636 3.0 3.0 skeletal system development 0.012 0.247 -9999.0 0.0 -0.945 8.0 8.0 IHH N/Hhip -0.055 0.196 -9999.0 0.0 -0.477 25.0 25.0 DHH N/Hhip -0.039 0.159 -9999.0 0.0 -0.416 23.0 23.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.018 0.2 -9999.0 0.0 -0.695 8.0 8.0 pancreas development -0.071 0.214 -9999.0 0.0 -0.578 23.0 23.0 HHAT -0.034 0.173 -9999.0 0.0 -0.602 13.0 13.0 PI3K 0.017 0.068 -9999.0 0.0 -0.464 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.243 0.291 -9999.0 0.0 -0.559 70.0 70.0 somite specification -0.018 0.2 -9999.0 0.0 -0.695 8.0 8.0 SHH Np/Cholesterol/PTCH1 -0.002 0.182 -9999.0 0.0 -0.607 8.0 8.0 SHH Np/Cholesterol/PTCH2 -0.005 0.109 -9999.0 0.0 -0.355 11.0 11.0 SHH Np/Cholesterol/Megalin -0.006 0.111 -9999.0 0.0 -0.355 11.0 11.0 SHH -0.018 0.14 -9999.0 0.0 -0.426 16.0 16.0 catabolic process 0.018 0.175 -9999.0 0.0 -0.806 5.0 5.0 SMO/Vitamin D3 -0.019 0.199 -9999.0 0.0 -0.611 10.0 10.0 SHH Np/Cholesterol/Hhip -0.055 0.172 -9999.0 0.0 -0.415 22.0 22.0 LRP2 0.015 0.041 -9999.0 0.0 -0.49 1.0 1.0 receptor-mediated endocytosis -0.004 0.189 -9999.0 0.0 -0.721 5.0 5.0 SHH Np/Cholesterol/BOC -0.018 0.121 -9999.0 0.0 -0.355 12.0 12.0 SHH Np/Cholesterol/CDO -0.008 0.112 -9999.0 0.0 -0.355 11.0 11.0 mesenchymal cell differentiation 0.055 0.171 0.412 22.0 -9999.0 0.0 22.0 mol:Vitamin D3 0.002 0.185 -9999.0 0.0 -0.644 7.0 7.0 IHH N/PTCH2 0.017 0.083 -9999.0 0.0 -0.482 3.0 3.0 CDON 0.011 0.057 -9999.0 0.0 -0.49 2.0 2.0 IHH N/PTCH1 0.019 0.179 -9999.0 0.0 -0.819 5.0 5.0 Megalin/LRPAP1 0.024 0.029 -9999.0 0.0 -0.341 1.0 1.0 PTCH2 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.016 0.108 -9999.0 0.0 -0.332 16.0 16.0 PTCH1 0.017 0.177 -9999.0 0.0 -0.812 5.0 5.0 HHIP -0.071 0.214 -9999.0 0.0 -0.579 23.0 23.0